108-556: Sir Adam Beck (June 20, 1857 – August 15, 1925) was a Canadian politician and hydroelectricity advocate who founded the Hydro-Electric Power Commission of Ontario . Beck was born in Baden , Canada West to German immigrants, Jacob Beck and Charlotte Hespeler (sister of William Hespeler ). He was the great-great-grandson of Count Károly Andrássy de Csíkszentkirály et Krasznahorka (1723–1795). He attended school at
216-415: A Rasmussen aneurysm , resulting in massive bleeding. Tuberculosis may become a chronic illness and cause extensive scarring in the upper lobes of the lungs. The upper lung lobes are more frequently affected by tuberculosis than the lower ones. The reason for this difference is not clear. It may be due to either better air flow, or poor lymph drainage within the upper lungs. In 15–20% of active cases,
324-737: A greenhouse gas . According to the World Commission on Dams report, where the reservoir is large compared to the generating capacity (less than 100 watts per square metre of surface area) and no clearing of the forests in the area was undertaken prior to impoundment of the reservoir, greenhouse gas emissions from the reservoir may be higher than those of a conventional oil-fired thermal generation plant. In boreal reservoirs of Canada and Northern Europe, however, greenhouse gas emissions are typically only 2% to 8% of any kind of conventional fossil-fuel thermal generation. A new class of underwater logging operation that targets drowned forests can mitigate
432-463: A low-head hydro power plant with hydrostatic head of few meters to few tens of meters can be classified either as an SHP or an LHP. The other distinction between SHP and LHP is the degree of the water flow regulation: a typical SHP primarily uses the natural water discharge with very little regulation in comparison to an LHP. Therefore, the term SHP is frequently used as a synonym for the run-of-the-river power plant . The largest power producers in
540-560: A common ancestor, remains unclear. A comparison of the genes of M. tuberculosis complex (MTBC) in humans to MTBC in animals suggests humans did not acquire MTBC from animals during animal domestication, as researchers previously believed. Both strains of the tuberculosis bacteria share a common ancestor, which could have infected humans even before the Neolithic Revolution . Skeletal remains show some prehistoric humans (4000 BC ) had TB, and researchers have found tubercular decay in
648-579: A condominium replica dubbed the Sir Adam Beck Manor. In Toronto, there is a statue of Beck ( Adam Beck Memorial ), sculpted by Emanuel Hahn, on University Avenue at Queen Street West. It was jointly erected by City of Toronto and the Toronto Hydro-Electric Commission in 1934. Hydroelectricity Hydroelectricity , or hydroelectric power , is electricity generated from hydropower (water power). Hydropower supplies 15% of
756-421: A flood and fail. Changes in the amount of river flow will correlate with the amount of energy produced by a dam. Lower river flows will reduce the amount of live storage in a reservoir therefore reducing the amount of water that can be used for hydroelectricity. The result of diminished river flow can be power shortages in areas that depend heavily on hydroelectric power. The risk of flow shortage may increase as
864-568: A horse show in 1897 he met Lilian Ottaway of Hamilton daughter of Cuthbert Ottaway and Marion Stinson . Lilian's mother, by then Marion Crerar, objected to their 21-year age difference – she was 19 and he 40 – as well as Beck's love of horse racing , which they felt would keep him away from home. Nevertheless, they were married on September 7, 1898. Beck named their London mansion Headley, after Lilian's parents' home in Surrey, England . In addition to horse breeding, for which he won numerous prizes, Beck
972-494: A hydroelectric complex is constructed, it produces no direct waste, and almost always emits considerably less greenhouse gas than fossil fuel -powered energy plants. However, when constructed in lowland rainforest areas, where part of the forest is inundated, substantial amounts of greenhouse gases may be emitted. Construction of a hydroelectric complex can have significant environmental impact, principally in loss of arable land and population displacement. They also disrupt
1080-809: A large natural height difference between two waterways, such as a waterfall or mountain lake. A tunnel is constructed to take water from the high reservoir to the generating hall built in a cavern near the lowest point of the water tunnel and a horizontal tailrace taking water away to the lower outlet waterway. A simple formula for approximating electric power production at a hydroelectric station is: P = − η ( m ˙ g Δ h ) = − η ( ( ρ V ˙ ) g Δ h ) {\displaystyle P=-\eta \ ({\dot {m}}g\ \Delta h)=-\eta \ ((\rho {\dot {V}})\ g\ \Delta h)} where Efficiency
1188-451: A larger amount of methane than those in temperate areas. Like other non-fossil fuel sources, hydropower also has no emissions of sulfur dioxide, nitrogen oxides, or other particulates. Reservoirs created by hydroelectric schemes often provide facilities for water sports , and become tourist attractions themselves. In some countries, aquaculture in reservoirs is common. Multi-use dams installed for irrigation support agriculture with
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#17328455309001296-680: A microscope. Since MTB retains certain stains even after being treated with acidic solution, it is classified as an acid-fast bacillus . The most common acid-fast staining techniques are the Ziehl–Neelsen stain and the Kinyoun stain , which dye acid-fast bacilli a bright red that stands out against a blue background. Auramine-rhodamine staining and fluorescence microscopy are also used. The M. tuberculosis complex (MTBC) includes four other TB-causing mycobacteria : M. bovis , M. africanum , M. canettii , and M. microti . M. africanum
1404-586: A positive risk adjusted return, unless appropriate risk management measures are put in place. While many hydroelectric projects supply public electricity networks, some are created to serve specific industrial enterprises. Dedicated hydroelectric projects are often built to provide the substantial amounts of electricity needed for aluminium electrolytic plants, for example. The Grand Coulee Dam switched to support Alcoa aluminium in Bellingham, Washington , United States for American World War II airplanes before it
1512-701: A public secondary school in London which is now home to the Thames Valley District School Board headquarters, an elementary school in Upper Beaches, Toronto, Ontario , and a bilingual elementary school in Etobicoke . Sir Adam Beck Public School was built in his hometown of Baden. In 1990, Headley, the Becks' mansion at Richmond and Sydenham streets, was demolished by Sifton Properties Ltd. and replaced with
1620-545: A relatively constant water supply. Large hydro dams can control floods, which would otherwise affect people living downstream of the project. Managing dams which are also used for other purposes, such as irrigation , is complicated. In 2021 the IEA called for "robust sustainability standards for all hydropower development with streamlined rules and regulations". Large reservoirs associated with traditional hydroelectric power stations result in submersion of extensive areas upstream of
1728-526: A result of climate change . One study from the Colorado River in the United States suggest that modest climate changes, such as an increase in temperature in 2 degree Celsius resulting in a 10% decline in precipitation, might reduce river run-off by up to 40%. Brazil in particular is vulnerable due to its heavy reliance on hydroelectricity, as increasing temperatures, lower water flow and alterations in
1836-448: A small TV/radio). Even smaller turbines of 200–300 W may power a few homes in a developing country with a drop of only 1 m (3 ft). A Pico-hydro setup is typically run-of-the-river , meaning that dams are not used, but rather pipes divert some of the flow, drop this down a gradient, and through the turbine before returning it to the stream. An underground power station is generally used at large facilities and makes use of
1944-407: A small decrease in case numbers. Some countries have legislation to involuntarily detain or examine those suspected to have tuberculosis, or involuntarily treat them if infected. The only available vaccine as of 2021 is bacillus Calmette-Guérin (BCG). In children it decreases the risk of getting the infection by 20% and the risk of infection turning into active disease by nearly 60%. It
2052-455: A source of low-cost renewable energy. Alternatively, small hydro projects may be built in isolated areas that would be uneconomic to serve from a grid, or in areas where there is no national electrical distribution network. Since small hydro projects usually have minimal reservoirs and civil construction work, they are seen as having a relatively low environmental impact compared to large hydro. This decreased environmental impact depends strongly on
2160-414: A start-up time of the order of a few minutes. Although battery power is quicker its capacity is tiny compared to hydro. It takes less than 10 minutes to bring most hydro units from cold start-up to full load; this is quicker than nuclear and almost all fossil fuel power. Power generation can also be decreased quickly when there is a surplus power generation. Hence the limited capacity of hydropower units
2268-581: A total of 1,500 terawatt-hours (TWh) of electrical energy in one full cycle" which was "about 170 times more energy than the global fleet of pumped storage hydropower plants". Battery storage capacity is not expected to overtake pumped storage during the 2020s. When used as peak power to meet demand, hydroelectricity has a higher value than baseload power and a much higher value compared to intermittent energy sources such as wind and solar. Hydroelectric stations have long economic lives, with some plants still in service after 50–100 years. Operating labor cost
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#17328455309002376-401: A tuberculosis infection does become active, it most commonly involves the lungs (in about 90% of cases). Symptoms may include chest pain and a prolonged cough producing sputum. About 25% of people may not have any symptoms (i.e., they remain asymptomatic). Occasionally, people may cough up blood in small amounts, and in very rare cases, the infection may erode into the pulmonary artery or
2484-474: A wide range of symptoms. Tuberculosis is spread from one person to the next through the air when people who have active TB in their lungs cough, spit, speak, or sneeze . People with latent TB do not spread the disease. Active infection occurs more often in people with HIV/AIDS and in those who smoke . Diagnosis of active TB is based on chest X-rays , as well as microscopic examination and culture of bodily fluids. Diagnosis of latent TB relies on
2592-491: A year's worth of rain fell within 24 hours (see 1975 Banqiao Dam failure ). The resulting flood resulted in the deaths of 26,000 people, and another 145,000 from epidemics. Millions were left homeless. The creation of a dam in a geologically inappropriate location may cause disasters such as 1963 disaster at Vajont Dam in Italy, where almost 2,000 people died. Tuberculosis Tuberculosis ( TB ), also known colloquially as
2700-398: Is Mycobacterium tuberculosis (MTB), a small, aerobic , nonmotile bacillus . The high lipid content of this pathogen accounts for many of its unique clinical characteristics. It divides every 16 to 20 hours, which is an extremely slow rate compared with other bacteria, which usually divide in less than an hour. Mycobacteria have an outer membrane lipid bilayer. If a Gram stain
2808-448: Is hydroelectric power on a scale serving a small community or industrial plant. The definition of a small hydro project varies but a generating capacity of up to 10 megawatts (MW) is generally accepted as the upper limit. This may be stretched to 25 MW and 30 MW in Canada and the United States. Small hydro stations may be connected to conventional electrical distribution networks as
2916-491: Is a growing problem, with increasing rates of multiple drug-resistant tuberculosis (MDR-TB). In 2018, one quarter of the world's population was thought to have a latent infection of TB. New infections occur in about 1% of the population each year. In 2022, an estimated 10.6 million people developed active TB, resulting in 1.3 million deaths, making it the second leading cause of death from an infectious disease after COVID-19 . As of 2018, most TB cases occurred in
3024-445: Is able to reproduce inside the macrophage and will eventually kill the immune cell. The primary site of infection in the lungs, known as the Ghon focus , is generally located in either the upper part of the lower lobe, or the lower part of the upper lobe . Tuberculosis of the lungs may also occur via infection from the blood stream. This is known as a Simon focus and is typically found in
3132-653: Is also rare and is seen almost only in immunodeficient people, although its prevalence may be significantly underestimated. Other known pathogenic mycobacteria include M. leprae , M. avium , and M. kansasii . The latter two species are classified as " nontuberculous mycobacteria " (NTM) or atypical mycobacteria. NTM cause neither TB nor leprosy , but they do cause lung diseases that resemble TB. When people with active pulmonary TB cough, sneeze, speak, sing, or spit, they expel infectious aerosol droplets 0.5 to 5.0 μm in diameter. A single sneeze can release up to 40,000 droplets. Each one of these droplets may transmit
3240-627: Is also usually low, as plants are automated and have few personnel on site during normal operation. Where a dam serves multiple purposes, a hydroelectric station may be added with relatively low construction cost, providing a useful revenue stream to offset the costs of dam operation. It has been calculated that the sale of electricity from the Three Gorges Dam will cover the construction costs after 5 to 8 years of full generation. However, some data shows that in most countries large hydropower dams will be too costly and take too long to build to deliver
3348-444: Is difficult, as is diagnosing the disease in those who have a weakened immune system. A diagnosis of TB should, however, be considered in those with signs of lung disease or constitutional symptoms lasting longer than two weeks. A chest X-ray and multiple sputum cultures for acid-fast bacilli are typically part of the initial evaluation. Interferon-γ release assays (IGRA) and tuberculin skin tests are of little use in most of
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3456-466: Is highest in the winter when solar energy is at a minimum. Pico hydro is hydroelectric power generation of under 5 kW . It is useful in small, remote communities that require only a small amount of electricity. For example, the 1.1 kW Intermediate Technology Development Group Pico Hydro Project in Kenya supplies 57 homes with very small electric loads (e.g., a couple of lights and a phone charger, or
3564-445: Is initially produced during construction of the project, and some methane is given off annually by reservoirs, hydro has one of the lowest lifecycle greenhouse gas emissions for electricity generation. The low greenhouse gas impact of hydroelectricity is found especially in temperate climates . Greater greenhouse gas emission impacts are found in the tropical regions because the reservoirs of power stations in tropical regions produce
3672-462: Is not an energy source, and appears as a negative number in listings. Run-of-the-river hydroelectric stations are those with small or no reservoir capacity, so that only the water coming from upstream is available for generation at that moment, and any oversupply must pass unused. A constant supply of water from a lake or existing reservoir upstream is a significant advantage in choosing sites for run-of-the-river. A tidal power station makes use of
3780-452: Is not generally used to produce base power except for vacating the flood pool or meeting downstream needs. Instead, it can serve as backup for non-hydro generators. The major advantage of conventional hydroelectric dams with reservoirs is their ability to store water at low cost for dispatch later as high value clean electricity. In 2021, the IEA estimated that the "reservoirs of all existing conventional hydropower plants combined can store
3888-500: Is not widespread, but it is a significant cause of tuberculosis in parts of Africa. M. bovis was once a common cause of tuberculosis, but the introduction of pasteurized milk has almost eliminated this as a public health problem in developed countries. M. canettii is rare and seems to be limited to the Horn of Africa , although a few cases have been seen in African emigrants. M. microti
3996-410: Is often higher (that is, closer to 1) with larger and more modern turbines. Annual electric energy production depends on the available water supply. In some installations, the water flow rate can vary by a factor of 10:1 over the course of a year. Hydropower is a flexible source of electricity since stations can be ramped up and down very quickly to adapt to changing energy demands. Hydro turbines have
4104-479: Is often used to screen people at high risk for TB. Those who have been previously immunized with the Bacille Calmette-Guerin vaccine may have a false-positive test result. The test may be falsely negative in those with sarcoidosis , Hodgkin's lymphoma , malnutrition , and most notably, active tuberculosis. Interferon gamma release assays , on a blood sample, are recommended in those who are positive to
4212-501: Is performed, MTB either stains very weakly "Gram-positive" or does not retain dye as a result of the high lipid and mycolic acid content of its cell wall. MTB can withstand weak disinfectants and survive in a dry state for weeks. In nature, the bacterium can grow only within the cells of a host organism, but M. tuberculosis can be cultured in the laboratory . Using histological stains on expectorated samples from phlegm (also called sputum), scientists can identify MTB under
4320-423: Is poor as of 2019 . The Centers for Disease Control and Prevention (CDC) stopped recommending yearly testing of health care workers without known exposure in 2019. Tuberculosis prevention and control efforts rely primarily on the vaccination of infants and the detection and appropriate treatment of active cases. The World Health Organization (WHO) has achieved some success with improved treatment regimens, and
4428-464: Is termed caseous necrosis . If TB bacteria gain entry to the blood stream from an area of damaged tissue, they can spread throughout the body and set up many foci of infection, all appearing as tiny, white tubercles in the tissues. This severe form of TB disease, most common in young children and those with HIV, is called miliary tuberculosis. People with this disseminated TB have a high fatality rate even with treatment (about 30%). In many people,
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4536-420: Is the most widely used vaccine worldwide, with more than 90% of all children being vaccinated. The immunity it induces decreases after about ten years. As tuberculosis is uncommon in most of Canada, Western Europe, and the United States, BCG is administered to only those people at high risk. Part of the reasoning against the use of the vaccine is that it makes the tuberculin skin test falsely positive, reducing
4644-657: The Bonneville Dam in 1937 and being recognized by the Flood Control Act of 1936 as the premier federal flood control agency. Hydroelectric power stations continued to become larger throughout the 20th century. Hydropower was referred to as "white coal". Hoover Dam 's initial 1,345 MW power station was the world's largest hydroelectric power station in 1936; it was eclipsed by the 6,809 MW Grand Coulee Dam in 1942. The Itaipu Dam opened in 1984 in South America as
4752-778: The International Exhibition of Hydropower and Tourism , with over one million visitors 1925. By 1920, when 40% of the power produced in the United States was hydroelectric, the Federal Power Act was enacted into law. The Act created the Federal Power Commission to regulate hydroelectric power stations on federal land and water. As the power stations became larger, their associated dams developed additional purposes, including flood control , irrigation and navigation . Federal funding became necessary for large-scale development, and federally owned corporations, such as
4860-578: The Rockwood Academy in Rockwood, Ontario . As a teenager he worked in his father's foundry , and later established a cigar-box manufacturing company in Galt (now Cambridge, Ontario ) with his brother William. In 1885, he moved the company to London, Ontario , where it quickly flourished and established Beck as a wealthy and influential civic leader. He was also involved in horse breeding and racing, and at
4968-605: The Tennessee Valley Authority (1933) and the Bonneville Power Administration (1937) were created. Additionally, the Bureau of Reclamation which had begun a series of western US irrigation projects in the early 20th century, was now constructing large hydroelectric projects such as the 1928 Hoover Dam . The United States Army Corps of Engineers was also involved in hydroelectric development, completing
5076-600: The United Farmers of Ontario swept the Conservatives out of power. Beck continued to push his radial railways proposal after World War I, which pitted him against Premier Ernest Drury , with whom he had an antagonistic relationship. In 1920, Drury created a Royal Commission , chaired by Robert Franklin Sutherland , which concluded that the popularity of automobiles had rendered Beck's proposal obsolete. During his time in
5184-569: The Vulcan Street Plant , began operating September 30, 1882, in Appleton, Wisconsin , with an output of about 12.5 kilowatts. By 1886 there were 45 hydroelectric power stations in the United States and Canada; and by 1889 there were 200 in the United States alone. At the beginning of the 20th century, many small hydroelectric power stations were being constructed by commercial companies in mountains near metropolitan areas. Grenoble , France held
5292-454: The lymphatic system (in scrofula of the neck), the genitourinary system (in urogenital tuberculosis ), and the bones and joints (in Pott disease of the spine), among others. A potentially more serious, widespread form of TB is called "disseminated tuberculosis"; it is also known as miliary tuberculosis . Miliary TB currently makes up about 10% of extrapulmonary cases. The main cause of TB
5400-506: The potential energy of dammed water driving a water turbine and generator . The power extracted from the water depends on the volume and on the difference in height between the source and the water's outflow. This height difference is called the head . A large pipe (the " penstock ") delivers water from the reservoir to the turbine. This method produces electricity to supply high peak demands by moving water between reservoirs at different elevations. At times of low electrical demand,
5508-420: The tuberculin skin test (TST) or blood tests. Prevention of TB involves screening those at high risk, early detection and treatment of cases, and vaccination with the bacillus Calmette-Guérin (BCG) vaccine. Those at high risk include household, workplace, and social contacts of people with active TB. Treatment requires the use of multiple antibiotics over a long period of time. Antibiotic resistance
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#17328455309005616-616: The " white death ", or historically as consumption , is an infectious disease usually caused by Mycobacterium tuberculosis (MTB) bacteria . Tuberculosis generally affects the lungs , but it can also affect other parts of the body. Most infections show no symptoms, in which case it is known as latent tuberculosis . Around 10% of latent infections progress to active disease that, if left untreated, kill about half of those affected. Typical symptoms of active TB are chronic cough with blood-containing mucus , fever , night sweats , and weight loss . Infection of other organs can cause
5724-463: The IEA released a main-case forecast of 141 GW generated by hydropower over 2022–2027, which is slightly lower than deployment achieved from 2017–2022. Because environmental permitting and construction times are long, they estimate hydropower potential will remain limited, with only an additional 40 GW deemed possible in the accelerated case. In 2021 the IEA said that major modernisation refurbishments are required. Most hydroelectric power comes from
5832-693: The Mantoux test. These are not affected by immunization or most environmental mycobacteria , so they generate fewer false-positive results. However, they are affected by M. szulgai , M. marinum , and M. kansasii . IGRAs may increase sensitivity when used in addition to the skin test, but may be less sensitive than the skin test when used alone. The US Preventive Services Task Force (USPSTF) has recommended screening people who are at high risk for latent tuberculosis with either tuberculin skin tests or interferon-gamma release assays . While some have recommend testing health care workers, evidence of benefit for this
5940-511: The United States test positive via the tuberculin test. Tuberculosis has been present in humans since ancient times . Tuberculosis has existed since antiquity . The oldest unambiguously detected M. tuberculosis gives evidence of the disease in the remains of bison in Wyoming dated to around 17,000 years ago. However, whether tuberculosis originated in bovines, then transferred to humans, or whether both bovine and human tuberculosis diverged from
6048-601: The WHO regions of South-East Asia (44%), Africa (24%), and the Western Pacific (18%), with more than 50% of cases being diagnosed in seven countries: India (27%), China (9%), Indonesia (8%), the Philippines (6%), Pakistan (6%), Nigeria (4%), and Bangladesh (4%). By 2021, the number of new cases each year was decreasing by around 2% annually. About 80% of people in many Asian and African countries test positive, while 5–10% of people in
6156-464: The ability to transport particles heavier than itself downstream. This has a negative effect on dams and subsequently their power stations, particularly those on rivers or within catchment areas with high siltation. Siltation can fill a reservoir and reduce its capacity to control floods along with causing additional horizontal pressure on the upstream portion of the dam. Eventually, some reservoirs can become full of sediment and useless or over-top during
6264-688: The active disease. Use of certain medications, such as corticosteroids and infliximab (an anti-αTNF monoclonal antibody), is another important risk factor, especially in the developed world . Other risk factors include: alcoholism , diabetes mellitus (3-fold increased risk), silicosis (30-fold increased risk), tobacco smoking (2-fold increased risk), indoor air pollution , malnutrition, young age, recently acquired TB infection, recreational drug use, severe kidney disease, low body weight, organ transplant, head and neck cancer, and genetic susceptibility (the overall importance of genetic risk factors remains undefined ). Tobacco smoking increases
6372-458: The arrival of streptomycin and other antibiotics, although the disease remained a significant threat. In 1946, the development of the antibiotic streptomycin made effective treatment and cure of TB a reality. Prior to the introduction of this medication, the only treatment was surgical intervention, including the " pneumothorax technique", which involved collapsing an infected lung to "rest" it and to allow tuberculous lesions to heal. Because of
6480-423: The bacterium is enveloped by the macrophage and stored temporarily in a membrane-bound vesicle called a phagosome. The phagosome then combines with a lysosome to create a phagolysosome. In the phagolysosome, the cell attempts to use reactive oxygen species and acid to kill the bacterium. However, M. tuberculosis has a thick, waxy mycolic acid capsule that protects it from these toxic substances. M. tuberculosis
6588-595: The balance between stream flow and power production. Micro hydro means hydroelectric power installations that typically produce up to 100 kW of power. These installations can provide power to an isolated home or small community, or are sometimes connected to electric power networks. There are many of these installations around the world, particularly in developing nations as they can provide an economical source of energy without purchase of fuel. Micro hydro systems complement photovoltaic solar energy systems because in many areas water flow, and thus available hydro power,
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#17328455309006696-425: The cattle and human tuberculosis diseases were similar, which delayed the recognition of infected milk as a source of infection. During the first half of the 1900s, the risk of transmission from this source was dramatically reduced after the application of the pasteurization process. Koch announced a glycerine extract of the tubercle bacilli as a "remedy" for tuberculosis in 1890, calling it "tuberculin". Although it
6804-480: The cause of pulmonary tuberculosis. J. L. Schönlein first published the name "tuberculosis" (German: Tuberkulose ) in 1832. Between 1838 and 1845, John Croghan, the owner of Mammoth Cave in Kentucky from 1839 onwards, brought a number of people with tuberculosis into the cave in the hope of curing the disease with the constant temperature and purity of the cave air; each died within a year. Hermann Brehmer opened
6912-404: The daily rise and fall of ocean water due to tides; such sources are highly predictable, and if conditions permit construction of reservoirs, can also be dispatchable to generate power during high demand periods. Less common types of hydro schemes use water's kinetic energy or undammed sources such as undershot water wheels . Tidal power is viable in a relatively small number of locations around
7020-505: The dams, sometimes destroying biologically rich and productive lowland and riverine valley forests, marshland and grasslands. Damming interrupts the flow of rivers and can harm local ecosystems, and building large dams and reservoirs often involves displacing people and wildlife. The loss of land is often exacerbated by habitat fragmentation of surrounding areas caused by the reservoir. Hydroelectric projects can be disruptive to surrounding aquatic ecosystems both upstream and downstream of
7128-700: The declaration of a global health emergency by the World Health Organization (WHO) in 1993. There is a popular misconception that tuberculosis is purely a disease of the lungs that manifests as coughing . Tuberculosis may infect many organs, even though it most commonly occurs in the lungs (known as pulmonary tuberculosis). Extrapulmonary TB occurs when tuberculosis develops outside of the lungs, although extrapulmonary TB may coexist with pulmonary TB. General signs and symptoms include fever, chills , night sweats, loss of appetite , weight loss, and fatigue . Significant nail clubbing may also occur. If
7236-640: The developing world. IGRA have similar limitations in those with HIV. A definitive diagnosis of TB is made by identifying M. tuberculosis in a clinical sample (e.g., sputum, pus , or a tissue biopsy ). However, the difficult culture process for this slow-growing organism can take two to six weeks for blood or sputum culture. Thus, treatment is often begun before cultures are confirmed. Nucleic acid amplification tests and adenosine deaminase testing may allow rapid diagnosis of TB. Blood tests to detect antibodies are not specific or sensitive , so they are not recommended. The Mantoux tuberculin skin test
7344-596: The disease became common among the urban poor. In 1815, one in four deaths in England was due to "consumption". By 1918, TB still caused one in six deaths in France. After TB was determined to be contagious, in the 1880s, it was put on a notifiable-disease list in Britain. Campaigns started to stop people from spitting in public places, and the infected poor were "encouraged" to enter sanatoria that resembled prisons. The sanatoria for
7452-620: The disease, since the infectious dose of tuberculosis is very small (the inhalation of fewer than 10 bacteria may cause an infection). People with prolonged, frequent, or close contact with people with TB are at particularly high risk of becoming infected, with an estimated 22% infection rate. A person with active but untreated tuberculosis may infect 10–15 (or more) other people per year. Transmission should occur from only people with active TB – those with latent infection are not thought to be contagious. The probability of transmission from one person to another depends upon several factors, including
7560-690: The effect of forest decay. Another disadvantage of hydroelectric dams is the need to relocate the people living where the reservoirs are planned. In 2000, the World Commission on Dams estimated that dams had physically displaced 40–80 million people worldwide. Because large conventional dammed-hydro facilities hold back large volumes of water, a failure due to poor construction, natural disasters or sabotage can be catastrophic to downriver settlements and infrastructure. During Typhoon Nina in 1975 Banqiao Dam in Southern China failed when more than
7668-463: The emergence of multidrug-resistant tuberculosis (MDR-TB), surgery has been re-introduced for certain cases of TB infections. It involves the removal of infected chest cavities ("bullae") in the lungs to reduce the number of bacteria and to increase exposure of the remaining bacteria to antibiotics in the bloodstream. Hopes of eliminating TB ended with the rise of drug-resistant strains in the 1980s. The subsequent resurgence of tuberculosis resulted in
7776-399: The excess generation capacity is used to pump water into the higher reservoir, thus providing demand side response . When the demand becomes greater, water is released back into the lower reservoir through a turbine. In 2021 pumped-storage schemes provided almost 85% of the world's 190 GW of grid energy storage and improve the daily capacity factor of the generation system. Pumped storage
7884-541: The first TB sanatorium in 1859 in Görbersdorf (now Sokołowsko ) in Silesia . In 1865, Jean Antoine Villemin demonstrated that tuberculosis could be transmitted, via inoculation, from humans to animals and among animals. (Villemin's findings were confirmed in 1867 and 1868 by John Burdon-Sanderson . ) Robert Koch identified and described the bacillus causing tuberculosis, M. tuberculosis , on 24 March 1882. In 1905, he
7992-585: The first chairman of the Hydro-Electric Power Commission. He was knighted by King George V in 1914 for his promotion of electricity and development of transmission lines. In 1915, he tried to introduce a network of interurban railways, known provincially as radials (long-distance trolleys) in Ontario under public ownership, but this plan had to be put on hold during World War I . In the 1919 post-war election, Beck lost his seat to Hugh Stevenson as
8100-615: The first genuine success in immunization against tuberculosis in 1906, using attenuated bovine-strain tuberculosis. It was called bacille Calmette–Guérin (BCG). The BCG vaccine was first used on humans in 1921 in France, but achieved widespread acceptance in the US, Great Britain, and Germany only after World War II. By the 1950s mortality in Europe had decreased about 90%. Improvements in sanitation, vaccination, and other public-health measures began significantly reducing rates of tuberculosis even before
8208-431: The host's immune system. Macrophages and dendritic cells in the granulomas are unable to present antigen to lymphocytes; thus the immune response is suppressed. Bacteria inside the granuloma can become dormant, resulting in latent infection. Another feature of the granulomas is the development of abnormal cell death ( necrosis ) in the center of tubercles . To the naked eye, this has the texture of soft, white cheese and
8316-400: The infected macrophages. When other macrophages attack the infected macrophage, they fuse together to form a giant multinucleated cell in the alveolar lumen. The granuloma may prevent dissemination of the mycobacteria and provide a local environment for interaction of cells of the immune system. However, more recent evidence suggests that the bacteria use the granulomas to avoid destruction by
8424-439: The infection spreads outside the lungs, causing other kinds of TB. These are collectively denoted as extrapulmonary tuberculosis. Extrapulmonary TB occurs more commonly in people with a weakened immune system and young children. In those with HIV, this occurs in more than 50% of cases. Notable extrapulmonary infection sites include the pleura (in tuberculous pleurisy), the central nervous system (in tuberculous meningitis ),
8532-613: The infection waxes and wanes. Tissue destruction and necrosis are often balanced by healing and fibrosis . Affected tissue is replaced by scarring and cavities filled with caseous necrotic material. During active disease, some of these cavities are joined to the air passages ( bronchi ) and this material can be coughed up. It contains living bacteria and thus can spread the infection. Treatment with appropriate antibiotics kills bacteria and allows healing to take place. Upon cure, affected areas are eventually replaced by scar tissue. Diagnosing active tuberculosis based only on signs and symptoms
8640-492: The largest amount for the region since 1990. Meanwhile, globally, hydropower generation increased by 70 TWh (up 2%) in 2022 and remains the largest renewable energy source, surpassing all other technologies combined. Hydropower has been used since ancient times to grind flour and perform other tasks. In the late 18th century hydraulic power provided the energy source needed for the start of the Industrial Revolution . In
8748-731: The largest, producing 14 GW , but was surpassed in 2008 by the Three Gorges Dam in China at 22.5 GW . Hydroelectricity would eventually supply some countries, including Norway , Democratic Republic of the Congo , Paraguay and Brazil , with over 85% of their electricity. In 2021 the International Energy Agency (IEA) said that more efforts are needed to help limit climate change . Some countries have highly developed their hydropower potential and have very little room for growth: Switzerland produces 88% of its potential and Mexico 80%. In 2022,
8856-609: The late 19th century, the electrical generator was developed and could now be coupled with hydraulics. The growing demand arising from the Industrial Revolution would drive development as well. In 1878, the world's first hydroelectric power scheme was developed at Cragside in Northumberland , England, by William Armstrong . It was used to power a single arc lamp in his art gallery. The old Schoelkopf Power Station No. 1 , US, near Niagara Falls , began to produce electricity in 1881. The first Edison hydroelectric power station,
8964-487: The life from the other family members. Although Richard Morton established the pulmonary form associated with tubercles as a pathology in 1689, due to the variety of its symptoms, TB was not identified as a single disease until the 1820s. Benjamin Marten conjectured in 1720 that consumptions were caused by microbes which were spread by people living close to each other. In 1819, René Laennec claimed that tubercles were
9072-488: The mid-1700s, French engineer Bernard Forest de Bélidor published Architecture Hydraulique , which described vertical- and horizontal-axis hydraulic machines, and in 1771 Richard Arkwright 's combination of water power , the water frame , and continuous production played a significant part in the development of the factory system, with modern employment practices. In the 1840s, hydraulic power networks were developed to generate and transmit hydro power to end users. By
9180-476: The middle and upper classes offered excellent care and constant medical attention. What later became known as the Alexandra Hospital for Children with Hip Disease (tuberculous arthritis) was opened in London in 1867. Whatever the benefits of the "fresh air" and labor in the sanatoria, even under the best conditions, 50% of those who entered died within five years ( c. 1916). Robert Koch did not believe
9288-651: The natural ecology of the river involved, affecting habitats and ecosystems, and siltation and erosion patterns. While dams can ameliorate the risks of flooding, dam failure can be catastrophic. In 2021, global installed hydropower electrical capacity reached almost 1,400 GW, the highest among all renewable energy technologies. Hydroelectricity plays a leading role in countries like Brazil, Norway and China. but there are geographical limits and environmental issues. Tidal power can be used in coastal regions. China added 24 GW in 2022, accounting for nearly three-quarters of global hydropower capacity additions. Europe added 2 GW,
9396-596: The newly infected person becomes infectious enough to transmit the disease to others. A number of factors make individuals more susceptible to TB infection and/or disease. The most important risk factor globally for developing active TB is concurrent HIV infection; 13% of those with TB are also infected with HIV. This is a particular problem in sub-Saharan Africa , where HIV infection rates are high. Of those without HIV infection who are infected with tuberculosis, about 5–10% develop active disease during their lifetimes; in contrast, 30% of those co-infected with HIV develop
9504-599: The number of infectious droplets expelled by the carrier, the effectiveness of ventilation, the duration of exposure, the virulence of the M. tuberculosis strain , the level of immunity in the uninfected person, and others. The cascade of person-to-person spread can be circumvented by segregating those with active ("overt") TB and putting them on anti-TB drug regimens. After about two weeks of effective treatment, subjects with nonresistant active infections generally do not remain contagious to others. If someone does become infected, it typically takes three to four weeks before
9612-633: The plant site. Generation of hydroelectric power changes the downstream river environment. Water exiting a turbine usually contains very little suspended sediment, which can lead to scouring of river beds and loss of riverbanks. The turbines also will kill large portions of the fauna passing through, for instance 70% of the eel passing a turbine will perish immediately. Since turbine gates are often opened intermittently, rapid or even daily fluctuations in river flow are observed. Drought and seasonal changes in rainfall can severely limit hydropower. Water may also be lost by evaporation. When water flows it has
9720-572: The privately owned companies who he felt did not adequately serve the needs of the public. With the slogan "Power at Cost" and in Latin , " dona naturae pro populo sunt " ("the gifts of nature are for the public"), he convinced Premier Whitney to create a board of enquiry on the matter, with him as chairman. The enquiry suggested creating a municipally owned hydroelectric system, funded by the provincial government, and using water from Niagara Falls and other Ontario lakes and rivers. In 1906 Whitney appointed Beck
9828-431: The provincial legislature Beck remained active in London. His daughter Marion, born in 1904, suffered from tuberculosis , but with Beck's wealth and influence she had access to the best doctors and medicine. Realizing that not everyone could afford such care, in 1910 Beck founded a sanitorium , which was very advanced for its time. The Queen Alexandra Sanitorium, named after Alexandra of Denmark , wife of King Edward VII ,
9936-450: The rainfall regime, could reduce total energy production by 7% annually by the end of the century. Lower positive impacts are found in the tropical regions. In lowland rainforest areas, where inundation of a part of the forest is necessary, it has been noted that the reservoirs of power plants produce substantial amounts of methane . This is due to plant material in flooded areas decaying in an anaerobic environment and forming methane,
10044-435: The risk of developing active TB increases to nearly 10% a year. If effective treatment is not given, the death rate for active TB cases is up to 66%. TB infection begins when the mycobacteria reach the alveolar air sacs of the lungs, where they invade and replicate within endosomes of alveolar macrophages . Macrophages identify the bacterium as foreign and attempt to eliminate it by phagocytosis . During this process,
10152-414: The risk of infections (in addition to increasing the risk of active disease and death). Additional factors increasing infection susceptibility include young age. About 90% of those infected with M. tuberculosis have asymptomatic , latent TB infections (sometimes called LTBI), with only a 10% lifetime chance that the latent infection will progress to overt, active tuberculous disease. In those with HIV,
10260-472: The spines of Egyptian mummies dating from 3000 to 2400 BC. Genetic studies suggest the presence of TB in the Americas from about AD 100. Before the Industrial Revolution , folklore often associated tuberculosis with vampires . When one member of a family died from the disease, the other infected members would lose their health slowly. People believed this was caused by the original person with TB draining
10368-465: The test's usefulness as a screening tool. Several vaccines are being developed. Intradermal MVA85A vaccine in addition to BCG injection is not effective in preventing tuberculosis. Public health campaigns which have focused on overcrowding, public spitting and regular sanitation (including hand washing) during the 1800s helped to either interrupt or slow spread which when combined with contact tracing, isolation and treatment helped to dramatically curb
10476-565: The top of the lung. This hematogenous transmission can also spread infection to more distant sites, such as peripheral lymph nodes, the kidneys, the brain, and the bones. All parts of the body can be affected by the disease, though for unknown reasons it rarely affects the heart , skeletal muscles , pancreas , or thyroid . Tuberculosis is classified as one of the granulomatous inflammatory diseases. Macrophages , epithelioid cells , T lymphocytes , B lymphocytes , and fibroblasts aggregate to form granulomas, with lymphocytes surrounding
10584-462: The transmission of both tuberculosis and other airborne diseases which led to the elimination of tuberculosis as a major public health issue in most developed economies. Other risk factors which worsened TB spread such as malnutrition were also ameliorated, but since the emergence of HIV a new population of immunocompromised individuals was available for TB to infect. During the HIV/AIDS epidemic in
10692-524: The world are hydroelectric power stations, with some hydroelectric facilities capable of generating more than double the installed capacities of the current largest nuclear power stations . Although no official definition exists for the capacity range of large hydroelectric power stations, facilities from over a few hundred megawatts are generally considered large hydroelectric facilities. Currently, only seven facilities over 10 GW ( 10,000 MW ) are in operation worldwide, see table below. Small hydro
10800-533: The world's electricity , almost 4,210 TWh in 2023, which is more than all other renewable sources combined and also more than nuclear power . Hydropower can provide large amounts of low-carbon electricity on demand, making it a key element for creating secure and clean electricity supply systems. A hydroelectric power station that has a dam and reservoir is a flexible source, since the amount of electricity produced can be increased or decreased in seconds or minutes in response to varying electricity demand. Once
10908-539: The world. The classification of hydropower plants starts with two top-level categories: The classification of a plant as an SHP or LHP is primarily based on its nameplate capacity , the threshold varies by the country, but in any case a plant with the capacity of 50 MW or more is considered an LHP. As an example, for China, SHP power is below 25 MW, for India - below 15 MW, most of Europe - below 10 MW. The SHP and LHP categories are further subdivided into many subcategories that are not mutually exclusive. For example,
11016-573: Was allowed to provide irrigation and power to citizens (in addition to aluminium power) after the war. In Suriname , the Brokopondo Reservoir was constructed to provide electricity for the Alcoa aluminium industry. New Zealand 's Manapouri Power Station was constructed to supply electricity to the aluminium smelter at Tiwai Point . Since hydroelectric dams do not use fuel, power generation does not produce carbon dioxide . While carbon dioxide
11124-595: Was also associated with tennis and lawn bowling . Also in 1898, Beck ran for provincial legislature for the first time, but lost. In 1900, Beck founded the London Health Association, which would later develop into the University and Victoria Hospitals. In 1902, he was elected mayor of London and a few months later was elected to the Ontario legislature as the Conservative member from the London riding . He
11232-514: Was awarded the Nobel Prize in Physiology or Medicine for this discovery. In Europe, rates of tuberculosis began to rise in the early 1600s to a peak level in the 1800s, when it caused nearly 25% of all deaths. In the 18th and 19th century, tuberculosis had become epidemic in Europe , showing a seasonal pattern. Tuberculosis caused widespread public concern in the 19th and early 20th centuries as
11340-468: Was not effective, it was later successfully adapted as a screening test for the presence of pre-symptomatic tuberculosis. World Tuberculosis Day is marked on 24 March each year, the anniversary of Koch's original scientific announcement. When the Medical Research Council formed in Britain in 1913, it initially focused on tuberculosis research. Albert Calmette and Camille Guérin achieved
11448-619: Was officially opened on April 5 of that year by Governor General Earl Grey . It was later renamed the Beck Memorial Sanitorium. Later still it was renamed the Children's Psychiatric Research Institute (CPRI). Today the building houses the London Child and Parent Resource Institute . In 1918 Beck also paid fellow Londoner Guy Lombardo to play at Marion's débutante party. Lilian Beck died of cancer on October 17, 1921. In 1923 Beck
11556-419: Was re-elected mayor in 1903 and 1904 while simultaneously serving as a member of the provincial legislature (which is no longer permitted). Already a wealthy man, he donated his salary to charity while serving as mayor. In 1905, he was appointed minister without portfolio in the government of premier Sir James P. Whitney . Beck was an early and prominent advocate of publicly owned electricity grids, opposing
11664-443: Was re-elected to the Ontario legislature, until his own death from anemia in 1925. Former Prime Minister of Canada Arthur Meighen , Ontario premier George Howard Ferguson , and London mayor George Wenige attended his funeral. The Queenston Chippawa power station (now Sir Adam Beck Hydroelectric Power Stations ), which he helped to create, was renamed after him in 1950. Also named for him were Sir Adam Beck Collegiate Institute,
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