A natural history museum or museum of natural history is a scientific institution with natural history collections that include current and historical records of animals , plants , fungi , ecosystems , geology , paleontology , climatology , and more.
138-707: The primary role of a natural history museum is to provide the scientific community with current and historical specimens for their research, which is to improve our understanding of the natural world. Some museums have public exhibits to share the beauty and wonder of the natural world with the public; these are referred to as 'public museums'. Some museums feature non-natural history collections in addition to their primary collections, such as ones related to history, art, and science. Renaissance cabinets of curiosities were private collections that typically included exotic specimens of national history, sometimes faked, along with other types of object. The first natural history museum
276-451: A eukaryotic organelle , the human mitochondrion (16,568 bp, about 16.6 kb [kilobase]), was reported in 1981, and the first chloroplast genomes followed in 1986. In 1992, the first eukaryotic chromosome , chromosome III of brewer's yeast Saccharomyces cerevisiae (315 kb) was sequenced. The first free-living organism to be sequenced was that of Haemophilus influenzae (1.8 Mb [megabase]) in 1995. The following year
414-427: A polyacrylamide gel (called polyacrylamide gel electrophoresis) and visualised using autoradiography. The procedure could sequence up to 80 nucleotides in one go and was a big improvement, but was still very laborious. Nevertheless, in 1977 his group was able to sequence most of the 5,386 nucleotides of the single-stranded bacteriophage φX174 , completing the first fully sequenced DNA-based genome. The refinement of
552-476: A 3'- OH group required for the formation of a phosphodiester bond between two nucleotides, causing DNA polymerase to cease extension of DNA when a ddNTP is incorporated. The ddNTPs may be radioactively or fluorescently labelled for detection in DNA sequencers . Typically, these machines can sequence up to 96 DNA samples in a single batch (run) in up to 48 runs a day. The high demand for low-cost sequencing has driven
690-632: A Preventive Genomics Clinic in August 2019, with Massachusetts General Hospital following a month later. The All of Us research program aims to collect genome sequence data from 1 million participants to become a critical component of the precision medicine research platform and the UK Biobank initiative has studied more than 500.000 individuals with deep genomic and phenotypic data. The growth of genomic knowledge has enabled increasingly sophisticated applications of synthetic biology . In 2010 researchers at
828-517: A base is incorporated. A microwell containing template DNA is flooded with a single nucleotide , if the nucleotide is complementary to the template strand it will be incorporated and a hydrogen ion will be released. This release triggers an ISFET ion sensor. If a homopolymer is present in the template sequence multiple nucleotides will be incorporated in a single flood cycle, and the detected electrical signal will be proportionally higher. Sequence assembly refers to aligning and merging fragments of
966-467: A combination of experimental and modeling approaches . The principal difference between structural genomics and traditional structural prediction is that structural genomics attempts to determine the structure of every protein encoded by the genome, rather than focusing on one particular protein. With full-genome sequences available, structure prediction can be done more quickly through a combination of experimental and modeling approaches, especially because
1104-471: A consortium of researchers from laboratories across North America , Europe , and Japan announced the completion of the first complete genome sequence of a eukaryote, S. cerevisiae (12.1 Mb), and since then genomes have continued being sequenced at an exponentially growing pace. As of October 2011 , the complete sequences are available for: 2,719 viruses , 1,115 archaea and bacteria , and 36 eukaryotes , of which about half are fungi . Most of
1242-453: A contractor when necessary. The cultural property stored in museums is threatened in many countries by natural disaster , war , terrorist attacks or other emergencies. To this end, an internationally important aspect is a strong bundling of existing resources and the networking of existing specialist competencies in order to prevent any loss or damage to cultural property or to keep damage as low as possible. International partner for museums
1380-464: A culture. As historian Steven Conn writes, "To see the thing itself, with one's own eyes and in a public place, surrounded by other people having some version of the same experience, can be enchanting." Museum purposes vary from institution to institution. Some favor education over conservation, or vice versa. For example, in the 1970s, the Canada Science and Technology Museum favored education over
1518-451: A field of study in biology ending in -omics , such as genomics, proteomics or metabolomics . The related suffix -ome is used to address the objects of study of such fields, such as the genome , proteome , or metabolome ( lipidome ) respectively. The suffix -ome as used in molecular biology refers to a totality of some sort; similarly omics has come to refer generally to the study of large, comprehensive biological data sets. While
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#17328509809951656-685: A full-time director to whom authority is delegated for day-to-day operations; Have the financial resources sufficient to operate effectively; Demonstrate that it meets the Core Standards for Museums; Successfully complete the Core Documents Verification Program". Additionally, there is a legal definition of museum in United States legislation authorizing the establishment of the Institute of Museum and Library Services : "Museum means
1794-501: A global level has been made possible only recently through the adaptation of genomic high-throughput assays. Metagenomics is the study of metagenomes , genetic material recovered directly from environmental samples. The broad field may also be referred to as environmental genomics, ecogenomics or community genomics. While traditional microbiology and microbial genome sequencing rely upon cultivated clonal cultures , early environmental gene sequencing cloned specific genes (often
1932-408: A high error rate at approximately 1 percent. Typically the short fragments, called reads, result from shotgun sequencing genomic DNA, or gene transcripts ( ESTs ). Assembly can be broadly categorized into two approaches: de novo assembly, for genomes which are not similar to any sequenced in the past, and comparative assembly, which uses the existing sequence of a closely related organism as
2070-501: A key role in the development of DNA sequencing techniques that enabled the establishment of comprehensive genome sequencing projects. In 1975, he and Alan Coulson published a sequencing procedure using DNA polymerase with radiolabelled nucleotides that he called the Plus and Minus technique . This involved two closely related methods that generated short oligonucleotides with defined 3' termini. These could be fractionated by electrophoresis on
2208-491: A mixed bag of state or provincial support as well as university funding, causing differing systems of development and goals. Opportunities for a new public audience coupled with overflowing artifact collections led to a new design for natural history museums. A dual arrangement of museums was pioneered by J. Edward Gray, who worked with the British Museum in the 1860s. This layout separated the science-producing researcher from
2346-427: A much longer DNA sequence in order to reconstruct the original sequence. This is needed as current DNA sequencing technology cannot read whole genomes as a continuous sequence, but rather reads small pieces of between 20 and 1000 bases, depending on the technology used. Third generation sequencing technologies such as PacBio or Oxford Nanopore routinely generate sequencing reads 10-100 kb in length; however, they have
2484-427: A much wider range of objects than a library , and usually focus on a specific theme, such as the arts , science , natural history or local history . Public museums that host exhibitions and interactive demonstrations are often tourist attractions , and many attract large numbers of visitors from outside their host country, with the most visited museums in the world attracting millions of visitors annually. Since
2622-459: A museum and on display, they not only got to show their fantastic finds but also used the museum as a way to sort and "manage the empirical explosion of materials that wider dissemination of ancient texts, increased travel, voyages of discovery, and more systematic forms of communication and exchange had produced". One of these naturalists and collectors was Ulisse Aldrovandi , whose collection policy of gathering as many objects and facts about them
2760-550: A museum is successful, as happened in Bilbao, others continue especially if a museum struggles to attract visitors. The Taubman Museum of Art is an example of an expensive museum (eventually $ 66 million) that attained little success and continues to have a low endowment for its size. Some museum activists see this method of museum use as a deeply flawed model for such institutions. Steven Conn, one such museum proponent, believes that "to ask museums to solve our political and economic problems
2898-402: A museum's collection typically determines the museum's size, whereas its collection reflects the type of museum it is. Many museums normally display a "permanent collection" of important selected objects in its area of specialization, and may periodically display "special collections" on a temporary basis. The following is a list to give an idea of the major museum types. While comprehensive, it
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#17328509809953036-509: A notable person, or a given period of time. Museums also can be based on the main source of funding: central or federal government, provinces, regions, universities; towns and communities; other subsidised; nonsubsidised and private. It may sometimes be useful to distinguish between diachronic museums which interpret the way its subject matter has developed and evolved through time (e.g., Lower East Side Tenement Museum and Diachronic Museum of Larissa ), and synchronic museums which interpret
3174-503: A palace of Henry VIII , in England opened the council room to the general public to create an interactive environment for visitors. Rather than allowing visitors to handle 500-year-old objects, however, the museum created replicas, as well as replica costumes. The daily activities, historic clothing, and even temperature changes immerse the visitor in an impression of what Tudor life may have been. Major professional organizations from around
3312-475: A protein of known structure or based on chemical and physical principles for a protein with no homology to any known structure. As opposed to traditional structural biology , the determination of a protein structure through a structural genomics effort often (but not always) comes before anything is known regarding the protein function. This raises new challenges in structural bioinformatics , i.e. determining protein function from its 3D structure. Epigenomics
3450-407: A public, tribal, or private nonprofit institution which is organized on a permanent basis for essentially educational, cultural heritage, or aesthetic purposes and which, using a professional staff: Owns or uses tangible objects, either animate or inanimate; Cares for these objects; and Exhibits them to the general public on a regular basis" (Museum Services Act 1976). One of the oldest museums known
3588-515: A range of software tools in their automated genome annotation pipeline. Structural annotation consists of the identification of genomic elements, primarily ORFs and their localisation, or gene structure. Functional annotation consists of attaching biological information to genomic elements. The need for reproducibility and efficient management of the large amount of data associated with genome projects mean that computational pipelines have important applications in genomics. Functional genomics
3726-432: A reference during assembly. Relative to comparative assembly, de novo assembly is computationally difficult ( NP-hard ), making it less favourable for short-read NGS technologies. Within the de novo assembly paradigm there are two primary strategies for assembly, Eulerian path strategies, and overlap-layout-consensus (OLC) strategies. OLC strategies ultimately try to create a Hamiltonian path through an overlap graph which
3864-894: A series of standards and best practices that help guide the management of museums. Various positions within the museum carry out the policies established by the Board and the Director. All museum employees should work together toward the museum's institutional goal. Here is a list of positions commonly found at museums: Other positions commonly found at museums include: building operator, public programming staff, photographer , librarian , archivist , groundskeeper , volunteer coordinator, preparator, security staff, development officer, membership officer, business officer, gift shop manager, public relations staff, and graphic designer . At smaller museums, staff members often fulfill multiple roles. Some of these positions are excluded entirely or may be carried out by
4002-434: A substantial amount of microbial DNA consists of prophage sequences and prophage-like elements. A detailed database mining of these sequences offers insights into the role of prophages in shaping the bacterial genome: Overall, this method verified many known bacteriophage groups, making this a useful tool for predicting the relationships of prophages from bacterial genomes. At present there are 24 cyanobacteria for which
4140-628: A total genome sequence is available. 15 of these cyanobacteria come from the marine environment. These are six Prochlorococcus strains, seven marine Synechococcus strains, Trichodesmium erythraeum IMS101 and Crocosphaera watsonii WH8501 . Several studies have demonstrated how these sequences could be used very successfully to infer important ecological and physiological characteristics of marine cyanobacteria. However, there are many more genome projects currently in progress, amongst those there are further Prochlorococcus and marine Synechococcus isolates, Acaryochloris and Prochloron ,
4278-457: A whole new science discipline. Following Rosalind Franklin 's confirmation of the helical structure of DNA, James D. Watson and Francis Crick 's publication of the structure of DNA in 1953 and Fred Sanger 's publication of the Amino acid sequence of insulin in 1955, nucleic acid sequencing became a major target of early molecular biologists . In 1964, Robert W. Holley and colleagues published
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4416-499: A year, to local molecular biology core facilities) which contain research laboratories with the costly instrumentation and technical support necessary. As sequencing technology continues to improve, however, a new generation of effective fast turnaround benchtop sequencers has come within reach of the average academic laboratory. On the whole, genome sequencing approaches fall into two broad categories, shotgun and high-throughput (or next-generation ) sequencing. Shotgun sequencing
4554-556: Is Ennigaldi-Nanna's museum , built by Princess Ennigaldi in modern Iraq at the end of the Neo-Babylonian Empire . The site dates from c. 530 BC , and contained artifacts from earlier Mesopotamian civilizations . Notably, a clay drum label—written in three languages—was found at the site, referencing the history and discovery of a museum item. Ancient Greeks and Romans collected and displayed art and objects but perceived museums differently from modern-day views. In
4692-747: Is UNESCO and Blue Shield International in accordance with the Hague Convention for the Protection of Cultural Property from 1954 and its 2nd Protocol from 1999. For legal reasons, there are many international collaborations between museums, and the local Blue Shield organizations. Blue Shield has conducted extensive missions to protect museums and cultural assets in armed conflict, such as 2011 in Egypt and Libya, 2013 in Syria and 2014 in Mali and Iraq. During these operations,
4830-502: Is a field of molecular biology that attempts to make use of the vast wealth of data produced by genomic projects (such as genome sequencing projects ) to describe gene (and protein ) functions and interactions. Functional genomics focuses on the dynamic aspects such as gene transcription , translation , and protein–protein interactions , as opposed to the static aspects of the genomic information such as DNA sequence or structures. Functional genomics attempts to answer questions about
4968-471: Is a sequencing method designed for analysis of DNA sequences longer than 1000 base pairs, up to and including entire chromosomes. It is named by analogy with the rapidly expanding, quasi-random firing pattern of a shotgun . Since gel electrophoresis sequencing can only be used for fairly short sequences (100 to 1000 base pairs), longer DNA sequences must be broken into random small segments which are then sequenced to obtain reads . Multiple overlapping reads for
5106-732: Is an NP-hard problem. Eulerian path strategies are computationally more tractable because they try to find a Eulerian path through a deBruijn graph. Finished genomes are defined as having a single contiguous sequence with no ambiguities representing each replicon . The DNA sequence assembly alone is of little value without additional analysis. Genome annotation is the process of attaching biological information to sequences , and consists of three main steps: Automatic annotation tools try to perform these steps in silico , as opposed to manual annotation (a.k.a. curation) which involves human expertise and potential experimental verification. Ideally, these approaches co-exist and complement each other in
5244-573: Is based on reversible dye-terminators and was developed in 1996 at the Geneva Biomedical Research Institute, by Pascal Mayer and Laurent Farinelli. In this method, DNA molecules and primers are first attached on a slide and amplified with polymerase so that local clonal colonies, initially coined "DNA colonies", are formed. To determine the sequence, four types of reversible terminator bases (RT-bases) are added and non-incorporated nucleotides are washed away. Unlike pyrosequencing,
5382-549: Is believed to be one of the earliest museums in the world. While it connected to the Library of Alexandria it is not clear if the museum was in a different building from the library or was part of the library complex. While little was known about the museum it was an inspiration for museums during the early Renaissance period. The royal palaces also functioned as a kind of museum outfitted with art and objects from conquered territories and gifts from ambassadors from other kingdoms allowing
5520-448: Is no longer a main purpose of most museums. While there is an ongoing debate about the purposes of interpretation of a museum's collection, there has been a consistent mission to protect and preserve cultural artifacts for future generations. Much care, expertise, and expense is invested in preservation efforts to retard decomposition in ageing documents, artifacts, artworks, and buildings. All museums display objects that are important to
5658-404: Is not a definitive list. Private museums are organized by individuals and managed by a board and museum officers, but public museums are created and managed by federal, state, or local governments. A government can charter a museum through legislative action but the museum can still be private as it is not part of the government. The distinction regulates the ownership and legal accountability for
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5796-438: Is not necessarily a negative development; Dorothy Canfield Fisher observed that the reduction in objects has pushed museums to grow from institutions that artlessly showcased their many artifacts (in the style of early cabinets of curiosity) to instead "thinning out" the objects presented "for a general view of any given subject or period, and to put the rest away in archive-storage-rooms, where they could be consulted by students,
5934-486: Is over-sampled is referred to as coverage . For much of its history, the technology underlying shotgun sequencing was the classical chain-termination method or ' Sanger method ', which is based on the selective incorporation of chain-terminating dideoxynucleotides by DNA polymerase during in vitro DNA replication . Recently, shotgun sequencing has been supplanted by high-throughput sequencing methods, especially for large-scale, automated genome analyses. However,
6072-616: Is particularly true in the case of postindustrial cities. Examples of museums fulfilling these economic roles exist around the world. For example, the Guggenheim Museum Bilbao was built in Bilbao, Spain in a move by the Basque regional government to revitalize the dilapidated old port area of that city. The Basque government agreed to pay $ 100 million for the construction of the museum, a price tag that caused many Bilbaoans to protest against
6210-676: Is the study of the complete set of epigenetic modifications on the genetic material of a cell, known as the epigenome . Epigenetic modifications are reversible modifications on a cell's DNA or histones that affect gene expression without altering the DNA sequence (Russell 2010 p. 475). Two of the most characterized epigenetic modifications are DNA methylation and histone modification . Epigenetic modifications play an important role in gene expression and regulation, and are involved in numerous cellular processes such as in differentiation/development and tumorigenesis . The study of epigenetics on
6348-417: Is to set them up for inevitable failure and to set us (the visitor) up for inevitable disappointment." Museums are facing funding shortages. Funding for museums comes from four major categories, and as of 2009 the breakdown for the United States is as follows: Government support (at all levels) 24.4%, private (charitable) giving 36.5%, earned income 27.6%, and investment income 11.5%. Government funding from
6486-411: The 16S rRNA gene) to produce a profile of diversity in a natural sample. Such work revealed that the vast majority of microbial biodiversity had been missed by cultivation-based methods. Recent studies use "shotgun" Sanger sequencing or massively parallel pyrosequencing to get largely unbiased samples of all genes from all the members of the sampled communities. Because of its power to reveal
6624-508: The Age of Enlightenment saw their ideas of the museum as superior and based their natural history museums on "organization and taxonomy" rather than displaying everything in any order after the style of Aldrovandi. The first "public" museums were often accessible only for the middle and upper classes. It could be difficult to gain entrance. When the British Museum opened to the public in 1759, it
6762-458: The American Alliance of Museums does not have such a definition, their list of accreditation criteria to participate in their Accreditation Program states a museum must: "Be a legally organized nonprofit institution or part of a nonprofit organization or government entity; Be essentially educational in nature; Have a formally stated and approved mission; Use and interpret objects or a site for
6900-641: The Ancient Greek Μουσεῖον ( mouseion ), which denotes a place or temple dedicated to the muses (the patron divinities in Greek mythology of the arts), and hence was a building set apart for study and the arts, especially the Musaeum (institute) for philosophy and research at Alexandria , built under Ptolemy I Soter about 280 BC. The purpose of modern museums is to collect, preserve, interpret, and display objects of artistic, cultural, or scientific significance for
7038-633: The J. Craig Venter Institute announced the creation of a partially synthetic species of bacterium , Mycoplasma laboratorium , derived from the genome of Mycoplasma genitalium . Population genomics has developed as a popular field of research, where genomic sequencing methods are used to conduct large-scale comparisons of DNA sequences among populations - beyond the limits of genetic markers such as short-range PCR products or microsatellites traditionally used in population genetics . Population genomics studies genome -wide effects to improve our understanding of microevolution so that we may learn
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#17328509809957176-526: The National Endowment for the Arts , the largest museum funder in the United States, decreased by 19.586 million between 2011 and 2015, adjusted for inflation. The average spent per visitor in an art museum in 2016 was $ 8 between admissions, store and restaurant, where the average expense per visitor was $ 55. Corporations , which fall into the private giving category, can be a good source of funding to make up
7314-610: The Newark Museum in a series of books in the early 20th century so that other museum founders could plan their museums. Dana suggested that potential founders of museums should form a committee first, and reach out to the community for input as to what the museum should supply or do for the community. According to Dana, museums should be planned according to community's needs: "The new museum ... does not build on an educational superstition. It examines its community's life first, and then straightway bends its energies to supplying some
7452-475: The Plus and Minus method resulted in the chain-termination, or Sanger method (see below ), which formed the basis of the techniques of DNA sequencing, genome mapping, data storage, and bioinformatic analysis most widely used in the following quarter-century of research. In the same year Walter Gilbert and Allan Maxam of Harvard University independently developed the Maxam-Gilbert method (also known as
7590-472: The Smithsonian Institution stated that he wanted to establish an institution "for the increase and diffusion of knowledge". In the late 19th century, museums of natural history exemplified the scientific drive for classifying life and interpreting the world. Their purpose was to gather examples from each field of knowledge for research and display. Concurrently, as American colleges expanded during
7728-607: The Titanic Belfast , built on disused shipyards in Belfast , Northern Ireland , incidentally for the same price as the Guggenheim Museum Bilbao and by the same architect, Frank Gehry , in time for the 100th anniversary of Titanic 's maiden voyage in 2012. Initially expecting modest visitor numbers of 425,000 annually, first year visitor numbers reached over 800,000, with almost 60% coming from outside Northern Ireland. In
7866-654: The United States Holocaust Memorial Museum in Washington, D.C. uses many artifacts in their memorable exhibitions. Museums are laid out in a specific way for a specific reason and each person who enters the doors of a museum will see its collection completely differently to the person behind them- this is what makes museums fascinating because they are represented differently to each individual. In recent years, some cities have turned to museums as an avenue for economic development or rejuvenation. This
8004-477: The chemical method ) of DNA sequencing, involving the preferential cleavage of DNA at known bases, a less efficient method. For their groundbreaking work in the sequencing of nucleic acids, Gilbert and Sanger shared half the 1980 Nobel Prize in chemistry with Paul Berg ( recombinant DNA ). The advent of these technologies resulted in a rapid intensification in the scope and speed of completion of genome sequencing projects . The first complete genome sequence of
8142-460: The domestication of the horse , using genetic samples from museum collections. New methods and technologies are being developed to support museomics . Museum A museum is an institution dedicated to displaying and/or preserving culturally or scientifically significant objects. Many museums have exhibitions of these objects on public display, and some have private collections that are used by researchers and specialists. Museums host
8280-478: The eukaryotic cell , while the fruit fly Drosophila melanogaster has been a very important tool (notably in early pre-molecular genetics ). The worm Caenorhabditis elegans is an often used simple model for multicellular organisms . The zebrafish Brachydanio rerio is used for many developmental studies on the molecular level, and the plant Arabidopsis thaliana is a model organism for flowering plants. The Japanese pufferfish ( Takifugu rubripes ) and
8418-466: The human genome was completed by the Human Genome Project in early 2001, creating much fanfare. This project, completed in 2003, sequenced the entire genome for one specific person, and by 2007 this sequence was declared "finished" (less than one error in 20,000 bases and all chromosomes assembled). In the years since then, the genomes of many other individuals have been sequenced, partly under
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#17328509809958556-834: The interpretive plan for an exhibit, determining the most effective, engaging and appropriate methods of communicating a message or telling a story. The process will often mirror the architectural process or schedule, moving from conceptual plan, through schematic design, design development, contract document, fabrication, and installation. Museums of all sizes may also contract the outside services of exhibit fabrication businesses. Some museum scholars have even begun to question whether museums truly need artifacts at all. Historian Steven Conn provocatively asks this question, suggesting that there are fewer objects in all museums now, as they have been progressively replaced by interactive technology. As educational programming has grown in museums, mass collections of objects have receded in importance. This
8694-442: The phylogenetic history and demography of a population. Population genomic methods are used for many different fields including evolutionary biology , ecology , biogeography , conservation biology and fisheries management . Similarly, landscape genomics has developed from landscape genetics to use genomic methods to identify relationships between patterns of environmental and genetic variation. Conservationists can use
8832-401: The spotted green pufferfish ( Tetraodon nigroviridis ) are interesting because of their small and compact genomes, which contain very little noncoding DNA compared to most species. The mammals dog ( Canis familiaris ), brown rat ( Rattus norvegicus ), mouse ( Mus musculus ), and chimpanzee ( Pan troglodytes ) are all important model animals in medical research. A rough draft of
8970-495: The 1860s. The British Museum was described by one of their delegates as a 'hakubutsukan', a 'house of extensive things' – this would eventually become accepted as the equivalent word for 'museum' in Japan and China. American museums eventually joined European museums as the world's leading centers for the production of new knowledge in their fields of interest. A period of intense museum building, in both an intellectual and physical sense
9108-510: The 19th century, they also developed their own natural history collections to support the education of their students. By the last quarter of the 19th century, scientific research in universities was shifting toward biological research on a cellular level, and cutting-edge research moved from museums to university laboratories. While many large museums, such as the Smithsonian Institution, are still respected as research centers, research
9246-595: The British Museum for its possession of rare antiquities from Egypt, Greece, and the Middle East. The roles associated with the management of a museum largely depend on the size of the institution. Together, the Board and the Director establish a system of governance that is guided by policies that set standards for the institution. Documents that set these standards include an institutional or strategic plan, institutional code of ethics, bylaws, and collections policy. The American Alliance of Museums (AAM) has also formulated
9384-416: The DNA chains are extended one nucleotide at a time and image acquisition can be performed at a delayed moment, allowing for very large arrays of DNA colonies to be captured by sequential images taken from a single camera. Decoupling the enzymatic reaction and the image capture allows for optimal throughput and theoretically unlimited sequencing capacity; with an optimal configuration, the ultimate throughput of
9522-637: The First World Congress on the Preservation and Conservation of Natural History Collections took place in Madrid, from 10 May 1992 to 15 May 1992. While the museum buildings where collections of artifacts were displayed started to overflow with materials, the prospect of a new building space would take years to build. As wealthy nations began to collect exotic artifacts and organisms from other countries, this problem continued to worsen. Museum funding came from
9660-449: The N 2 -fixing filamentous cyanobacteria Nodularia spumigena , Lyngbya aestuarii and Lyngbya majuscula , as well as bacteriophages infecting marine cyanobaceria. Thus, the growing body of genome information can also be tapped in a more general way to address global problems by applying a comparative approach. Some new and exciting examples of progress in this field are the identification of genes for regulatory RNAs, insights into
9798-477: The Sanger method remains in wide use, primarily for smaller-scale projects and for obtaining especially long contiguous DNA sequence reads (>500 nucleotides). Chain-termination methods require a single-stranded DNA template, a DNA primer , a DNA polymerase , normal deoxynucleosidetriphosphates (dNTPs), and modified nucleotides (dideoxyNTPs) that terminate DNA strand elongation. These chain-terminating nucleotides lack
9936-684: The United States, several Native American tribes and advocacy groups have lobbied extensively for the repatriation of sacred objects and the reburial of human remains. In 1990, Congress passed the Native American Graves Protection and Repatriation Act (NAGPRA), which required federal agencies and federally funded institutions to repatriate Native American "cultural items" to culturally affiliate tribes and groups. Similarly, many European museum collections often contain objects and cultural artifacts acquired through imperialism and colonization . Some historians and scholars have criticized
10074-532: The United States, similar projects include the 81,000 square foot Taubman Museum of Art in Roanoke, Virginia and The Broad in Los Angeles . Museums being used as a cultural economic driver by city and local governments has proven to be controversial among museum activists and local populations alike. Public protests have occurred in numerous cities which have tried to employ museums in this way. While most subside if
10212-570: The auspices of the 1000 Genomes Project , which announced the sequencing of 1,092 genomes in October 2012. Completion of this project was made possible by the development of dramatically more efficient sequencing technologies and required the commitment of significant bioinformatics resources from a large international collaboration. The continued analysis of human genomic data has profound political and social repercussions for human societies. The English-language neologism omics informally refers to
10350-411: The availability of large numbers of sequenced genomes and previously solved protein structures allow scientists to model protein structure on the structures of previously solved homologs. Structural genomics involves taking a large number of approaches to structure determination, including experimental methods using genomic sequences or modeling-based approaches based on sequence or structural homology to
10488-596: The biological perspective in exhibits to teach the public more about the functional relationships between organisms. This required the expertise of zoologist and botanist. As this kind of work was not typical for educated scientists of the time, the new profession of curator developed. Natural history collections are invaluable repositories of genomic information that can be used to examine the histories of biodiversity and environmental change. Collaborations between museums and researchers worldwide are enabling scientists to unravel ecological and evolutionary relationships such as
10626-474: The care of the collections. Genomic Genomics is an interdisciplinary field of molecular biology focusing on the structure, function, evolution, mapping, and editing of genomes . A genome is an organism's complete set of DNA , including all of its genes as well as its hierarchical, three-dimensional structural configuration. In contrast to genetics , which refers to the study of individual genes and their roles in inheritance, genomics aims at
10764-431: The chosen artifacts. These elements of planning have their roots with John Cotton Dana, who was perturbed at the historical placement of museums outside of cities, and in areas that were not easily accessed by the public, in gloomy European style buildings. Questions of accessibility continue to the present day. Many museums strive to make their buildings, programming, ideas, and collections more publicly accessible than in
10902-404: The classical period, the museums were the temples and their precincts which housed collections of votive offerings. Paintings and sculptures were displayed in gardens, forums, theaters, and bathhouses. In the ancient past there was little differentiation between libraries and museums with both occupying the building and were frequently connected to a temple or royal palace. The Museum of Alexandria
11040-401: The collective characterization and quantification of all of an organism's genes, their interrelations and influence on the organism. Genes may direct the production of proteins with the assistance of enzymes and messenger molecules. In turn, proteins make up body structures such as organs and tissues as well as control chemical reactions and carry signals between cells. Genomics also involves
11178-448: The development of high-throughput sequencing technologies that parallelize the sequencing process, producing thousands or millions of sequences at once. High-throughput sequencing is intended to lower the cost of DNA sequencing beyond what is possible with standard dye-terminator methods. In ultra-high-throughput sequencing, as many as 500,000 sequencing-by-synthesis operations may be run in parallel. The Illumina dye sequencing method
11316-539: The development of more modern 19th-century museums was part of new strategies by Western governments to produce a citizenry that, rather than be directed by coercive or external forces, monitored and regulated its own conduct. To incorporate the masses in this strategy, the private space of museums that previously had been restricted and socially exclusive were made public. As such, objects and artifacts, particularly those related to high culture, became instruments for these "new tasks of social management". Universities became
11454-413: The establishment of the earliest known museum in ancient times , museums have been associated with academia and the preservation of rare items. Museums originated as private collections of interesting items, and not until much later did the emphasis on educating the public take root. The English word museum comes from Latin , and is pluralized as museums (or rarely, musea ). It is originally from
11592-623: The evolutionary origin of photosynthesis , or estimation of the contribution of horizontal gene transfer to the genomes that have been analyzed. Genomics has provided applications in many fields, including medicine , biotechnology , anthropology and other social sciences . Next-generation genomic technologies allow clinicians and biomedical researchers to drastically increase the amount of genomic data collected on large study populations. When combined with new informatics approaches that integrate many kinds of data with genomic data in disease research, this allows researchers to better understand
11730-545: The first nucleic acid sequence ever determined, the ribonucleotide sequence of alanine transfer RNA . Extending this work, Marshall Nirenberg and Philip Leder revealed the triplet nature of the genetic code and were able to determine the sequences of 54 out of 64 codons in their experiments. In 1972, Walter Fiers and his team at the Laboratory of Molecular Biology of the University of Ghent ( Ghent , Belgium ) were
11868-465: The first to determine the sequence of a gene: the gene for Bacteriophage MS2 coat protein. Fiers' group expanded on their MS2 coat protein work, determining the complete nucleotide-sequence of bacteriophage MS2-RNA (whose genome encodes just four genes in 3569 base pairs [bp]) and Simian virus 40 in 1976 and 1978, respectively. In addition to his seminal work on the amino acid sequence of insulin, Frederick Sanger and his colleagues played
12006-409: The former use and status of an object. Religious or holy objects, for instance, are handled according to cultural rules. Jewish objects that contain the name of God may not be discarded, but need to be buried. Although most museums do not allow physical contact with the associated artifacts, there are some that are interactive and encourage a more hands-on approach. In 2009, Hampton Court Palace ,
12144-430: The function of DNA at the levels of genes, RNA transcripts, and protein products. A key characteristic of functional genomics studies is their genome-wide approach to these questions, generally involving high-throughput methods rather than a more traditional "gene-by-gene" approach. A major branch of genomics is still concerned with sequencing the genomes of various organisms, but the knowledge of full genomes has created
12282-697: The funding gap. The amount corporations currently give to museums accounts for just 5% of total funding. Corporate giving to the arts, however, was set to increase by 3.3% in 2017. Most mid-size and large museums employ exhibit design staff for graphic and environmental design projects, including exhibitions. In addition to traditional 2-D and 3-D designers and architects, these staff departments may include audio-visual specialists, software designers, audience research, evaluation specialists, writers, editors, and preparators or art handlers. These staff specialists may also be charged with supervising contract design or production services. The exhibit design process builds on
12420-480: The genetic bases of drug response and disease. Early efforts to apply the genome to medicine included those by a Stanford team led by Euan Ashley who developed the first tools for the medical interpretation of a human genome. The Genomes2People research program at Brigham and Women’s Hospital , Broad Institute and Harvard Medical School was established in 2012 to conduct empirical research in translating genomics into health. Brigham and Women's Hospital opened
12558-486: The genome) phenomena such as epistasis (effect of one gene on another), pleiotropy (one gene affecting more than one trait), heterosis (hybrid vigour), and other interactions between loci and alleles within the genome. From the Greek ΓΕΝ gen , "gene" (gamma, epsilon, nu, epsilon) meaning "become, create, creation, birth", and subsequent variants: genealogy, genesis, genetics, genic, genomere, genotype, genus etc. While
12696-425: The growth in the use of the term has led some scientists ( Jonathan Eisen , among others ) to claim that it has been oversold, it reflects the change in orientation towards the quantitative analysis of complete or near-complete assortment of all the constituents of a system. In the study of symbioses , for example, researchers which were once limited to the study of a single gene product can now simultaneously compare
12834-438: The information gathered by genomic sequencing in order to better evaluate genetic factors key to species conservation, such as the genetic diversity of a population or whether an individual is heterozygous for a recessive inherited genetic disorder. By using genomic data to evaluate the effects of evolutionary processes and to detect patterns in variation throughout a given population, conservationists can formulate plans to aid
12972-464: The instrument depends only on the A/D conversion rate of the camera. The camera takes images of the fluorescently labeled nucleotides, then the dye along with the terminal 3' blocker is chemically removed from the DNA, allowing the next cycle. An alternative approach, ion semiconductor sequencing, is based on standard DNA replication chemistry. This technology measures the release of a hydrogen ion each time
13110-422: The looting of the collection is to be prevented in particular. The design of museums has evolved throughout history. However, museum planning involves planning the actual mission of the museum along with planning the space that the collection of the museum will be housed in. Intentional museum planning has its beginnings with the museum founder and librarian John Cotton Dana . Dana detailed the process of founding
13248-407: The material which that community needs, and to making that material's presence widely known, and to presenting it in such a way as to secure it for the maximum of use and the maximum efficiency of that use." The way that museums are planned and designed vary according to what collections they house, but overall, they adhere to planning a space that is easily accessed by the public and easily displays
13386-469: The microorganisms whose genomes have been completely sequenced are problematic pathogens , such as Haemophilus influenzae , which has resulted in a pronounced bias in their phylogenetic distribution compared to the breadth of microbial diversity. Of the other sequenced species, most were chosen because they were well-studied model organisms or promised to become good models. Yeast ( Saccharomyces cerevisiae ) has long been an important model organism for
13524-409: The museum landscape has become so varied, that it may not be sufficient to use traditional categories to comprehend fully the vast variety existing throughout the world. However, it may be useful to categorize museums in different ways under multiple perspectives. Museums can vary based on size, from large institutions, to very small institutions focusing on specific subjects, such as a specific location,
13662-590: The museum planning process. Some museum experiences have very few or no artifacts and do not necessarily call themselves museums, and their mission reflects this; the Griffith Observatory in Los Angeles and the National Constitution Center in Philadelphia , being notable examples where there are few artifacts, but strong, memorable stories are told or information is interpreted. In contrast,
13800-519: The natural history museum was a new space for public interaction with the natural world. Museums began to change the way they exhibited their artifacts, hiring various forms of curators, to refine their displays. Additionally, they adopted new approaches to designing exhibits. These new ways of organizing would support learning of the lay audience. Organised by the League of Nations , the first International Museography Congress happened in Madrid in 1934. Again,
13938-516: The only people who really needed to see them". This phenomenon of disappearing objects is especially present in science museums like the Museum of Science and Industry in Chicago , which have a high visitorship of school-aged children who may benefit more from hands-on interactive technology than reading a label beside an artifact. There is no definitive standard as to the set types of museums. Additionally,
14076-415: The past. Not every museum is participating in this trend, but that seems to be the trajectory of museums in the twenty-first century with its emphasis on inclusiveness. One pioneering way museums are attempting to make their collections more accessible is with open storage. Most of a museum's collection is typically locked away in a secure location to be preserved, but the result is most people never get to see
14214-512: The personal collection of Elias Ashmole , was set up in the University of Oxford to be open to the public and is considered by some to be the first modern public museum. The collection included that of Elias Ashmole which he had collected himself, including objects he had acquired from the gardeners, travellers and collectors John Tradescant the elder and his son of the same name . The collection included antique coins, books, engravings, geological specimens, and zoological specimens—one of which
14352-415: The possibility for the field of functional genomics , mainly concerned with patterns of gene expression during various conditions. The most important tools here are microarrays and bioinformatics . Structural genomics seeks to describe the 3-dimensional structure of every protein encoded by a given genome . This genome-based approach allows for a high-throughput method of structure determination by
14490-411: The possibility of diverse audiences, instead adopting the view of an expert as the standard. The mid-eighteenth century saw an increased interest in the scientific world by the middle class bourgeoisie who had greater time for leisure activities, physical mobility and educational opportunities than in previous eras. Other forms of science consumption, such as the zoo, had already grown in popularity. Now,
14628-674: The preservation of their objects. They displayed objects as well as their functions. One exhibit featured a historical printing press that a staff member used for visitors to create museum memorabilia. Some museums seek to reach a wide audience, such as a national or state museum, while others have specific audiences, like the LDS Church History Museum or local history organizations. Generally speaking, museums collect objects of significance that comply with their mission statement for conservation and display. Apart from questions of provenance and conservation, museums take into consideration
14766-433: The previously hidden diversity of microscopic life, metagenomics offers a powerful lens for viewing the microbial world that has the potential to revolutionize understanding of the entire living world. Bacteriophages have played and continue to play a key role in bacterial genetics and molecular biology . Historically, they were used to define gene structure and gene regulation. Also the first genome to be sequenced
14904-422: The primary centers for innovative research in the United States well before the start of World War II . Nevertheless, museums to this day contribute new knowledge to their fields and continue to build collections that are useful for both research and display. The late twentieth century witnessed intense debate concerning the repatriation of religious, ethnic, and cultural artifacts housed in museum collections. In
15042-442: The private collections of wealthy individuals, families or institutions of art and rare or curious natural objects and artifacts . These were often displayed in so-called "wonder rooms" or cabinets of curiosities . These contemporary museums first emerged in western Europe, then spread into other parts of the world. Public access to these museums was often possible for the "respectable", especially to private art collections, but at
15180-400: The project. Nonetheless, over 1.1 million people visited the museum in 2015, indicating it appeared to have paid off for the local government despite local backlash; key to this is the large demographic of foreign visitors to the museum, with 63% of the visitors residing outside of Spain and thus feeding foreign investment straight into Bilbao. A similar project to that undertaken in Bilbao was
15318-484: The public presentation of regularly scheduled programs and exhibits; Have a formal and appropriate program of documentation, care, and use of collections or objects; Carry out the above functions primarily at a physical facility or site; Have been open to the public for at least two years; Be open to the public at least 1,000 hours a year; Have accessioned 80 percent of its permanent collection; Have at least one paid professional staff with museum knowledge and experience; Have
15456-407: The public, accessible and inclusive, museums foster diversity and sustainability. They operate and communicate ethically, professionally and with the participation of communities, offering varied experiences for education, enjoyment, reflection and knowledge sharing." The Canadian Museums Association 's definition: "A museum is a non-profit, permanent establishment, that does not exist primarily for
15594-708: The purpose of conducting temporary exhibitions and that is open to the public during regular hours and administered in the public interest for the purpose of conserving, preserving, studying, interpreting, assembling and exhibiting to the public for the instruction and enjoyment of the public, objects and specimens or educational and cultural value including artistic, scientific, historical and technological material." The United Kingdom's Museums Association 's definition: "Museums enable people to explore collections for inspiration, learning and enjoyment. They are institutions that collect, safeguard and make accessible artifacts and specimens, which they hold in trust for society." While
15732-572: The ruler to display the amassed collections to guests and to visiting dignitaries. Also in Alexandria from the time of Ptolemy II Philadelphus (r. 285–246 BCE), was the first zoological park. At first used by Philadelphus in an attempt to domesticate African elephants for use in war, the elephants were also used for show along with a menagerie of other animals specimens including hartebeests , ostriches , zebras , leopards , giraffes , rhinoceros , and pythons . Early museums began as
15870-660: The same annotation pipeline (also see below ). Traditionally, the basic level of annotation is using BLAST for finding similarities, and then annotating genomes based on homologues. More recently, additional information is added to the annotation platform. The additional information allows manual annotators to deconvolute discrepancies between genes that are given the same annotation. Some databases use genome context information, similarity scores, experimental data, and integrations of other resources to provide genome annotations through their Subsystems approach. Other databases (e.g. Ensembl ) rely on both curated data sources as well as
16008-459: The science-consuming public audience. By doing so, museums were able to save space in the exhibit areas and display a smaller, more focused amount of material to the public. This also allowed for greater curation of exhibits that eased the lay viewer's learning and allowed them to develop a more holistic understanding of the natural world. Natural history museums became a story of our world, telling different organisms narratives. Use of dual arrangement
16146-429: The sequencing and analysis of genomes through uses of high throughput DNA sequencing and bioinformatics to assemble and analyze the function and structure of entire genomes. Advances in genomics have triggered a revolution in discovery-based research and systems biology to facilitate understanding of even the most complex biological systems such as the brain. The field also includes studies of intragenomic (within
16284-461: The study and education of the public. To city leaders, an active museum community can be seen as a gauge of the cultural or economic health of a city, and a way to increase the sophistication of its inhabitants. To museum professionals, a museum might be seen as a way to educate the public about the museum's mission, such as civil rights or environmentalism . Museums are, above all, storehouses of knowledge. In 1829, James Smithson's bequest funding
16422-451: The subject matter which now include content in the form of images, audio and visual effects, and interactive exhibits. Museum creation begins with a museum plan, created through a museum planning process. The process involves identifying the museum's vision and the resources, organization and experiences needed to realize this vision. A feasibility study, analysis of comparable facilities, and an interpretive plan are all developed as part of
16560-405: The target DNA are obtained by performing several rounds of this fragmentation and sequencing. Computer programs then use the overlapping ends of different reads to assemble them into a continuous sequence. Shotgun sequencing is a random sampling process, requiring over-sampling to ensure a given nucleotide is represented in the reconstructed sequence; the average number of reads by which a genome
16698-507: The total complement of several types of biological molecules. After an organism has been selected, genome projects involve three components: the sequencing of DNA, the assembly of that sequence to create a representation of the original chromosome, and the annotation and analysis of that representation. Historically, sequencing was done in sequencing centers , centralized facilities (ranging from large independent institutions such as Joint Genome Institute which sequence dozens of terabases
16836-494: The type of collections they display, to include: fine arts , applied arts , craft , archaeology , anthropology and ethnology , biography , history , cultural history , science , technology , children's museums , natural history , botanical and zoological gardens . Within these categories, many museums specialize further, e.g., museums of modern art , folk art , local history , military history , aviation history , philately , agriculture , or geology . The size of
16974-471: The vast majority of collections. The Brooklyn Museum's Luce Center for American Art practices this open storage where the public can view items not on display, albeit with minimal interpretation. The practice of open storage is all part of an ongoing debate in the museum field of the role objects play and how accessible they should be. In terms of modern museums, interpretive museums, as opposed to art museums, have missions reflecting curatorial guidance through
17112-754: The way its subject matter existed at a certain point in time (e.g., the Anne Frank House and Colonial Williamsburg ). According to University of Florida Professor Eric Kilgerman, "While a museum in which a particular narrative unfolds within its halls is diachronic, those museums that limit their space to a single experience are called synchronic." In her book Civilizing the Museum , author Elaine Heumann Gurian proposes that there are five categories of museums based on intention and not content: object centered, narrative, client centered, community centered, and national. Museums can also be categorized into major groups by
17250-428: The whim of the owner and his staff. One way that elite men during this time period gained a higher social status in the world of elites was by becoming a collector of these curious objects and displaying them. Many of the items in these collections were new discoveries and these collectors or naturalists, since many of these people held interest in natural sciences, were eager to obtain them. By putting their collections in
17388-632: The word genome (from the German Genom , attributed to Hans Winkler ) was in use in English as early as 1926, the term genomics was coined by Tom Roderick, a geneticist at the Jackson Laboratory ( Bar Harbor, Maine ), over beers with Jim Womack, Tom Shows and Stephen O’Brien at a meeting held in Maryland on the mapping of the human genome in 1986. First as the name for a new journal and then as
17526-475: The world offer some definitions as to what constitutes a museum, and their purpose. Common themes in all the definitions are public good and the care, preservation, and interpretation of collections. The International Council of Museums ' current definition of a museum (adopted in 2022): "A museum is a not-for-profit, permanent institution in the service of society that researches, collects, conserves, interprets and exhibits tangible and intangible heritage. Open to
17664-536: Was "encyclopedic" in nature, reminiscent of that of Pliny, the Roman philosopher and naturalist. The idea was to consume and collect as much knowledge as possible, to put everything they collected and everything they knew in these displays. In time, however, museum philosophy would change and the encyclopedic nature of information that was so enjoyed by Aldrovandi and his cohorts would be dismissed as well as "the museums that contained this knowledge". The 18th-century scholars of
17802-507: Was a bacteriophage . However, bacteriophage research did not lead the genomics revolution, which is clearly dominated by bacterial genomics. Only very recently has the study of bacteriophage genomes become prominent, thereby enabling researchers to understand the mechanisms underlying phage evolution. Bacteriophage genome sequences can be obtained through direct sequencing of isolated bacteriophages, but can also be derived as part of microbial genomes. Analysis of bacterial genomes has shown that
17940-435: Was a concern that large crowds could damage the artifacts. Prospective visitors to the British Museum had to apply in writing for admission, and small groups were allowed into the galleries each day. The British Museum became increasingly popular during the 19th century, amongst all age groups and social classes who visited the British Museum, especially on public holidays. The Ashmolean Museum , however, founded in 1677 from
18078-492: Was charged with organizing the Louvre as a national public museum and the centerpiece of a planned national museum system. As Napoléon I conquered the great cities of Europe, confiscating art objects as he went, the collections grew and the organizational task became more and more complicated. After Napoleon was defeated in 1815, many of the treasures he had amassed were gradually returned to their owners (and many were not). His plan
18216-760: Was never fully realized, but his concept of a museum as an agent of nationalistic fervor had a profound influence throughout Europe. Chinese and Japanese visitors to Europe were fascinated by the museums they saw there, but had cultural difficulties in grasping their purpose and finding an equivalent Chinese or Japanese term for them. Chinese visitors in the early 19th century named these museums based on what they contained, so defined them as "bone amassing buildings" or "courtyards of treasures" or "painting pavilions" or "curio stores" or "halls of military feats" or "gardens of everything". Japan first encountered Western museum institutions when it participated in Europe's World's Fairs in
18354-627: Was possibly that of Swiss scholar Conrad Gessner , established in Zürich in the mid-16th century. The National Museum of Natural History , established in Paris in 1635, was the first natural history museum to take the form that would be recognized as a natural history museum today. Early natural history museums offered limited accessibility, as they were generally private collections or holdings of scientific societies. The Ashmolean Museum , opened in England in 1683,
18492-457: Was quickly adopted and advocated by many across the world. A notable proponent of its use was German zoologist Karl Mobias who divided the natural museum in Hamburg in 1866. The goal of such museums was not only to display organisms, but detail their interactions in the human world as well as within their unique ecosystems. Naturalists such as American Joseph Leidy pushed for greater emphasis on
18630-642: Was realized in the late 19th and early 20th centuries (this is often called "The Museum Period" or "The Museum Age"). While many American museums, both natural history museums and art museums alike, were founded with the intention of focusing on the scientific discoveries and artistic developments in North America, many moved to emulate their European counterparts in certain ways (including the development of Classical collections from ancient Egypt , Greece , Mesopotamia , and Rome ). Drawing on Michel Foucault 's concept of liberal government, Tony Bennett has suggested
18768-729: Was the Louvre in Paris , opened in 1793 during the French Revolution , which enabled for the first time free access to the former French royal collections for people of all stations and status. The fabulous art treasures collected by the French monarchy over centuries were accessible to the public three days each " décade " (the 10-day unit which had replaced the week in the French Republican Calendar ). The Conservatoire du muséum national des Arts (National Museum of Arts's Conservatory)
18906-724: Was the first natural history museum to grant admission to the general public. The natural history museum did not exist as a typical museum prior to the eighteenth century. Civic and university buildings did exist to house collections used for conducting research, however these served more as storage spaces than museums by today's understanding. All kept artifacts were displayed to the public as catalogs of research findings and served mostly as an archive of scientific knowledge. These spaces housed as many artifacts as fit and offered little description or interpretation for visitors. Kept organisms were typically arranged in their taxonomic systems and displayed with similar organisms. Museums did not think of
19044-473: Was the stuffed body of the last dodo ever seen in Europe; but by 1755 the stuffed dodo was so moth-eaten that it was destroyed, except for its head and one claw. The museum opened on 24 May 1683, with naturalist Robert Plot as the first keeper. The first building, which became known as the Old Ashmolean , is sometimes attributed to Sir Christopher Wren or Thomas Wood. In France, the first public museum
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