Misplaced Pages

#402597

97-398: The meaning of the word protection, as used in the electrical industry, is no different to that in everyday use. People protect themselves against personal or financial loss by means of insurance and from injury or discomfort by the use of protective clothing. They further protect their property by the installation of security measures such as locks and/or alarm systems. Some kind of protection

194-485: A MEK inhibitor trametinib . In February 2024, the Food and Drug Administration approved the first cancer treatment that uses tumor-infiltrating lymphocytes, also called TIL therapy, specifically for melanomas that have not improved with other treatments. Additionally, scientists are testing a vaccine designed to match the unique genetic details of a patient's cancer in an advanced clinical trial. Currently, surgical excision

291-449: A UV-signature mutation indicating that these cancers are caused by UVB radiation via direct DNA damage. However malignant melanoma is predominantly caused by UVA radiation via indirect DNA damage. The indirect DNA damage is caused by free radicals and reactive oxygen species. Research indicates that the absorption of three sunscreen ingredients into the skin, combined with a 60-minute exposure to UV, leads to an increase of free radicals in

388-483: A boundary of 190 nm between hard and soft UV regions. Very hot objects emit UV radiation (see black-body radiation ). The Sun emits ultraviolet radiation at all wavelengths, including the extreme ultraviolet where it crosses into X-rays at 10 nm. Extremely hot stars (such as O- and B-type) emit proportionally more UV radiation than the Sun. Sunlight in space at the top of Earth's atmosphere (see solar constant )

485-559: A cyst or another type of cancer. Ultraviolet radiation from sun exposure is the primary environmental cause of skin cancer. This can occur in professions such as farming. Other risk factors that play a role include: UV-irradiation of skin cells causes damage to DNA through photochemical reactions . Cyclobutane pyrimidine dimers formed by adjacent thymine bases, or by adjacent cytosine bases, are frequent types of DNA damage induced by UV. Human skin cells are capable of repairing most UV-induced damage by nucleotide excision repair ,

582-433: A deep-bluish-purple Wood's glass optical filter that blocks almost all visible light with wavelengths longer than 400 nanometers. The purple glow given off by these tubes is not the ultraviolet itself, but visible purple light from mercury's 404 nm spectral line which escapes being filtered out by the coating. Other black lights use plain glass instead of the more expensive Wood's glass, so they appear light-blue to

679-495: A few. There is insufficient evidence either for or against screening for skin cancers. Vitamin supplements and antioxidant supplements have not been found to have an effect in prevention. Evidence for reducing melanoma risk from dietary measures is tentative, with some supportive epidemiological evidence, but no clinical trials. Zinc oxide and titanium oxide are often used in sunscreen to provide broad protection from UVA and UVB ranges. Eating certain foods may decrease

776-671: A filter coating which absorbs most visible light. Halogen lamps with fused quartz envelopes are used as inexpensive UV light sources in the near UV range, from 400 to 300 nm, in some scientific instruments. Due to its black-body spectrum a filament light bulb is a very inefficient ultraviolet source, emitting only a fraction of a percent of its energy as UV. Specialized UV gas-discharge lamps containing different gases produce UV radiation at particular spectral lines for scientific purposes. Argon and deuterium arc lamps are often used as stable sources, either windowless or with various windows such as magnesium fluoride . These are often

873-556: A given time and location. This standard shows that most sunburn happens due to UV at wavelengths near the boundary of the UVA and UVB bands. Overexposure to UVB radiation not only can cause sunburn but also some forms of skin cancer . However, the degree of redness and eye irritation (which are largely not caused by UVA) do not predict the long-term effects of UV, although they do mirror the direct damage of DNA by ultraviolet. Skin cancer Skin cancers are cancers that arise from

970-406: A linear scar. If the repair is made along a natural skin fold or wrinkle line, the scar will be hardly visible. Larger defects may require repair with a skin graft, local skin flap, pedicled skin flap, or a microvascular free flap. Skin grafts and local skin flaps are by far more common than the other listed choices. Skin grafting is patching of a defect with skin that is removed from another site in

1067-418: A method of closing defects with tissue that closely matches the defect in color and quality. Skin from the periphery of the defect site is mobilized and repositioned to fill the deficit. Various forms of local flaps can be designed to minimize disruption to surrounding tissues and maximize cosmetic outcome of the reconstruction. Pedicled skin flaps are a method of transferring skin with an intact blood supply from

SECTION 10

#1732833605403

1164-450: A nearby region of the body. An example of such reconstruction is a pedicled forehead flap for the repair of a large nasal skin defect. Once the flap develops a source of blood supply form its new bed, the vascular pedicle can be detached. The mortality rate of basal-cell and squamous-cell carcinoma is around 0.3%, causing 2000 deaths per year in the US. In comparison, the mortality rate of melanoma

1261-403: A number of less common skin cancers, are known as nonmelanoma skin cancer (NMSC). Basal-cell cancer grows slowly and can damage the tissue around it but is unlikely to spread to distant areas or result in death. It often appears as a painless raised area of skin that may be shiny with small blood vessels running over it or may present as a raised area with an ulcer . Squamous-cell skin cancer

1358-556: A number of measures including decreasing indoor tanning and mid-day sun exposure, increasing the use of sunscreen , and avoiding the use of tobacco products . It is important to limit sun exposure and to avoid tanning beds, because they both involve UV light. UV light is known to damage skin cells by mutating their DNA. The mutated DNA can cause tumors and other growths to form on the skin. Further, there are other risk factors beside just UV exposure. Fair skin, prolonged history of sunburns, moles, and family history of skin cancer are just

1455-545: A number of ranges recommended by the ISO standard ISO 21348: Several solid-state and vacuum devices have been explored for use in different parts of the UV spectrum. Many approaches seek to adapt visible light-sensing devices, but these can suffer from unwanted response to visible light and various instabilities. Ultraviolet can be detected by suitable photodiodes and photocathodes , which can be tailored to be sensitive to different parts of

1552-429: A period of two weeks. In a full thickness skin graft, a segment of skin is totally removed and the donor site needs to be sutured closed. Split thickness grafts can be used to repair larger defects, but the grafts are inferior in their cosmetic appearance. Full thickness skin grafts are more acceptable cosmetically. However, full thickness grafts can only be used for small or moderate sized defects. Local skin flaps are

1649-412: A process that protects against skin cancer, but may be inadequate at high levels of exposure. A malignant epithelial tumor that primarily originates in the epidermis, in squamous mucosa or in areas of squamous metaplasia is referred to as a squamous-cell carcinoma. Macroscopically, the tumor is often elevated, fungating , or may be ulcerated with irregular borders. Microscopically, tumor cells destroy

1746-475: A thinner ozone layer . Tanning beds are another common source of ultraviolet radiation. For melanomas and basal-cell cancers, exposure during childhood is particularly harmful. For squamous-cell skin cancers, total exposure, irrespective of when it occurs, is more important. Between 20% and 30% of melanomas develop from moles. People with lighter skin are at higher risk as are those with poor immune function such as from medications or HIV/AIDS . Diagnosis

1843-520: A typical efficiency of approximately 30–40%, meaning that for every 100 watts of electricity consumed by the lamp, they will produce approximately 30–40 watts of total UV output. They also emit bluish-white visible light, due to mercury's other spectral lines. These "germicidal" lamps are used extensively for disinfection of surfaces in laboratories and food-processing industries, and for disinfecting water supplies. 'Black light' incandescent lamps are also made from an incandescent light bulb with

1940-444: A vaccine that stimulates the production of a protein critical to the skin's antioxidant network could reinforce people's defenses against skin cancer. Treatment is dependent on the specific type of cancer, location of the cancer, age of the person, and whether the cancer is primary or a recurrence. For a small basal-cell cancer in a young person, the treatment with the best cure rate ( Mohs surgery or CCPDMA ) might be indicated. In

2037-449: A variety of wavelength bands into the vacuum ultraviolet. Light-emitting diodes (LEDs) can be manufactured to emit radiation in the ultraviolet range. In 2019, following significant advances over the preceding five years, UVA LEDs of 365 nm and longer wavelength were available, with efficiencies of 50% at 1.0 W output. Currently, the most common types of UV LEDs are in 395 nm and 365 nm wavelengths, both of which are in

SECTION 20

#1732833605403

2134-468: A year as of 2010, 49,000 of which are due to melanoma and 31,000 of which are due to non-melanoma skin cancers. This is up from 51,000 in 1990. More than 3.5 million cases of skin cancer are diagnosed annually in the United States, which makes it the most common form of cancer in that country. One in five Americans will develop skin cancer at some point of their lives. The most common form of skin cancer

2231-469: Is ionizing radiation . Consequently, short-wave UV damages DNA and sterilizes surfaces with which it comes into contact. For humans, suntan and sunburn are familiar effects of exposure of the skin to UV, along with an increased risk of skin cancer . The amount of UV radiation produced by the Sun means that the Earth would not be able to sustain life on dry land if most of that light were not filtered out by

2328-435: Is 15–20% and it causes 6500 deaths per year. Even though it is much less common, malignant melanoma is responsible for 75% of all skin cancer-related deaths. The survival rate for people with melanoma depends upon when they start treatment. The cure rate is very high when melanoma is detected in early stages, when it can easily be removed surgically. The prognosis is less favorable if the melanoma has spread to other parts of

2425-454: Is a characteristic of all life, as living things have evolved at least some protective mechanisms to counter damaging environmental phenomena, such as ultraviolet light . Biological membranes such as bark on trees and skin on animals offer protection from various threats, with skin playing a key role in protecting organisms against pathogens and excessive water loss. Additional structures like scales and hair offer further protection from

2522-504: Is a rough estimate; good statistics are not kept. Of nonmelanoma skin cancers, about 80% are basal-cell cancers and 20% squamous-cell skin cancers. Basal-cell and squamous-cell skin cancers rarely result in death. In the United States, they were the cause of less than 0.1% of all cancer deaths. Globally in 2012, melanoma occurred in 232,000 people and resulted in 55,000 deaths. White people in Australia , New Zealand and South Africa have

2619-1048: Is about 126 nm, characteristic of the Ar 2 * excimer laser. Direct UV-emitting laser diodes are available at 375 nm. UV diode-pumped solid state lasers have been demonstrated using cerium - doped lithium strontium aluminum fluoride crystals (Ce:LiSAF), a process developed in the 1990s at Lawrence Livermore National Laboratory . Wavelengths shorter than 325 nm are commercially generated in diode-pumped solid-state lasers . Ultraviolet lasers can also be made by applying frequency conversion to lower-frequency lasers. Ultraviolet lasers have applications in industry ( laser engraving ), medicine ( dermatology , and keratectomy ), chemistry ( MALDI ), free-air secure communications , computing ( optical storage ), and manufacture of integrated circuits. The vacuum ultraviolet (V‑UV) band (100–200 nm) can be generated by non-linear 4 wave mixing in gases by sum or difference frequency mixing of 2 or more longer wavelength lasers. The generation

2716-617: Is by biopsy . Decreasing exposure to ultraviolet radiation and the use of sunscreen appear to be effective methods of preventing melanoma and squamous-cell skin cancer. It is not clear if sunscreen affects the risk of basal-cell cancer. Nonmelanoma skin cancer is usually curable. Treatment is generally by surgical removal but may, less commonly, involve radiation therapy or topical medications such as fluorouracil . Treatment of melanoma may involve some combination of surgery, chemotherapy , radiation therapy and targeted therapy . In those people whose disease has spread to other areas of

2813-600: Is commonly a red, scaling, thickened patch on sun-exposed skin. Some are firm hard nodules and dome shaped like keratoacanthomas . Ulceration and bleeding may occur. When SCC is not treated, it may develop into a large mass. Squamous-cell is the second most common skin cancer. It is dangerous, but not nearly as dangerous as a melanoma. Most melanoma consist of various colours from shades of brown to black. A small number of melanoma are pink, red or fleshy in colour; these are called amelanotic melanoma and tend to be more aggressive. Warning signs of malignant melanoma include change in

2910-412: Is composed of about 50% infrared light, 40% visible light, and 10% ultraviolet light, for a total intensity of about 1400 W/m in vacuum. The atmosphere blocks about 77% of the Sun's UV, when the Sun is highest in the sky (at zenith), with absorption increasing at shorter UV wavelengths. At ground level with the sun at zenith, sunlight is 44% visible light, 3% ultraviolet, and the remainder infrared. Of

3007-448: Is generally done in gasses (e.g. krypton, hydrogen which are two-photon resonant near 193 nm) or metal vapors (e.g. magnesium). By making one of the lasers tunable, the V‑UV can be tuned. If one of the lasers is resonant with a transition in the gas or vapor then the V‑UV production is intensified. However, resonances also generate wavelength dispersion, and thus the phase matching can limit

Protection - Misplaced Pages Continue

3104-497: Is in direct proportion to the degree of bright sunlight the body receives. Serotonin is thought to provide sensations of happiness, well-being and serenity to human beings. UV rays also treat certain skin conditions. Modern phototherapy has been used to successfully treat psoriasis , eczema , jaundice , vitiligo , atopic dermatitis , and localized scleroderma . In addition, UV radiation, in particular UVB radiation, has been shown to induce cell cycle arrest in keratinocytes ,

3201-553: Is limited, such as the face. Cure rates are equivalent to wide excision. Special training is required to perform this technique. An alternative method is CCPDMA and can be performed by a pathologist not familiar with Mohs surgery . In the case of disease that has spread (metastasized), further surgical procedures or chemotherapy may be required. Treatments for metastatic melanoma include biologic immunotherapy agents ipilimumab , pembrolizumab , nivolumab , cemiplimab ; BRAF inhibitors , such as vemurafenib and dabrafenib ; and

3298-521: Is more likely to spread. It usually presents as a hard lump with a scaly top but may also form an ulcer. Melanomas are the most aggressive. Signs include a mole that has changed in size, shape, color, has irregular edges, has more than one color, is itchy or bleeds. More than 90% of cases are caused by exposure to ultraviolet radiation from the Sun . This exposure increases the risk of all three main types of skin cancer. Exposure has increased, partly due to

3395-471: Is needed to support this. Computer-assisted diagnosis devices have been developed that analyze images from a dermatoscope or spectroscopy and can be used by a diagnostician to aid in the detection of skin cancer. CAD systems have been found to be highly sensitive in the detection of melanoma, but have a high false-positive rate. There is not yet enough evidence to recommend CAD as compared to traditional diagnostic methods. High-frequency ultrasound (HFUS)

3492-419: Is no doubt that a little sunlight is good for you! But 5–15 minutes of casual sun exposure of hands, face and arms two to three times a week during the summer months is sufficient to keep your vitamin D levels high. Vitamin D can also be obtained from food and supplementation. Excess sun exposure produces harmful effects, however. Vitamin D promotes the creation of serotonin . The production of serotonin

3589-513: Is not emitted by the laser, but rather by electron transitions in an extremely hot tin or xenon plasma, which is excited by an excimer laser. This technique does not require a synchrotron, yet can produce UV at the edge of the X‑ray spectrum. Synchrotron light sources can also produce all wavelengths of UV, including those at the boundary of the UV and X‑ray spectra at 10 nm. The impact of ultraviolet radiation on human health has implications for

3686-768: Is of unclear usefulness in the diagnosis of skin cancer. There is insufficient evidence for reflectance confocal microscopy to diagnose basal cell or squamous cell carcinoma or any other skin cancers. Sunscreen is effective and thus recommended to prevent melanoma and squamous-cell carcinoma. There is little evidence that it is effective in preventing basal-cell carcinoma. Other advice to reduce rates of skin cancer includes avoiding sunburn, wearing protective clothing, sunglasses and hats, and attempting to avoid sun exposure or periods of peak exposure. The U.S. Preventive Services Task Force recommends that people between 9 and 25 years of age be advised to avoid ultraviolet light. The risk of developing skin cancer can be reduced through

3783-498: Is planned to be used to calibrate the color cameras for the 2019 ESA Mars rover mission, since they will remain unfaded by the high level of UV present at the surface of Mars. Common soda–lime glass , such as window glass, is partially transparent to UVA, but is opaque to shorter wavelengths, passing about 90% of the light above 350 nm, but blocking over 90% of the light below 300 nm. A study found that car windows allow 3–4% of ambient UV to pass through, especially if

3880-538: Is poorly responsive to radiation or chemotherapy. For low-risk disease, radiation therapy ( external beam radiotherapy or brachytherapy ), topical chemotherapy ( imiquimod or 5-fluorouracil) and cryotherapy (freezing the cancer off) can provide adequate control of the disease; all of them, however, may have lower overall cure rates than certain type of surgery. Other modalities of treatment such as photodynamic therapy, epidermal radioisotope therapy , topical chemotherapy, electrodesiccation and curettage can be found in

3977-409: Is present in sunlight , and constitutes about 10% of the total electromagnetic radiation output from the Sun. It is also produced by electric arcs , Cherenkov radiation , and specialized lights, such as mercury-vapor lamps , tanning lamps , and black lights . The photons of ultraviolet have greater energy than those of visible light, from about 3.1 to 12  electron volts , around

Protection - Misplaced Pages Continue

4074-563: Is the most common form of treatment for skin cancers. The goal of reconstructive surgery is the restoration of normal appearance and function. The choice of technique in reconstruction is dictated by the size and location of the defect. Excision and reconstruction of facial skin cancers are generally more challenging due to the presence of highly visible and functional anatomic structures in the face. When skin defects are small in size, most can be repaired with simple repair where skin edges are approximated and closed with sutures. This will result in

4171-475: Is the most common type of cancer in people between 15 and 44 years in both countries. The incidence of skin cancer has been increasing. The incidence of melanoma among Auckland residents of European descent in 1995 was 77.7 cases per 100,000 people per year, and was predicted to increase in the 21st century because of "the effect of local stratospheric ozone depletion and the time lag from sun exposure to melanoma development." Skin cancers result in 80,000 deaths

4268-446: Is visible to insects, some mammals, and some birds . Birds have a fourth color receptor for ultraviolet rays; this, coupled with eye structures that transmit more UV gives smaller birds "true" UV vision. "Ultraviolet" means "beyond violet" (from Latin ultra , "beyond"), violet being the color of the highest frequencies of visible light . Ultraviolet has a higher frequency (thus a shorter wavelength) than violet light. UV radiation

4365-537: The UV degradation (photo-oxidation) of a material. The absorbers can themselves degrade over time, so monitoring of absorber levels in weathered materials is necessary. In sunscreen , ingredients that absorb UVA/UVB rays, such as avobenzone , oxybenzone and octyl methoxycinnamate , are organic chemical absorbers or "blockers". They are contrasted with inorganic absorbers/"blockers" of UV radiation such as carbon black , titanium dioxide , and zinc oxide . For clothing,

4462-399: The atmosphere . More energetic, shorter-wavelength "extreme" UV below 121 nm ionizes air so strongly that it is absorbed before it reaches the ground. However, UV (specifically, UVB) is also responsible for the formation of vitamin D in most land vertebrates , including humans. The UV spectrum, thus, has effects both beneficial and detrimental to life. The lower wavelength limit of

4559-420: The basement membrane and form sheets or compact masses which invade the subjacent connective tissue (dermis). In well differentiated carcinomas, tumor cells are pleomorphic /atypical, but resembling normal keratinocytes from prickle layer (large, polygonal, with abundant eosinophilic (pink) cytoplasm and central nucleus). Their disposal tends to be similar to that of normal epidermis: immature/basal cells at

4656-494: The body . As of 2003 the overall five-year cure rate with Mohs' micrographic surgery was around 95 percent for recurrent basal cell carcinoma. Australia and New Zealand exhibit one of the highest rates of skin cancer incidence in the world, almost four times the rates registered in the United States, the UK and Canada . Around 434,000 people receive treatment for non-melanoma skin cancers and 10,300 are treated for melanoma. Melanoma

4753-421: The skin that do not heal, ulcering in the skin, discolored skin, and changes in existing moles , such as jagged edges to the mole, enlargement of the mole, changes in color, the way it feels or if it bleeds. Other common signs of skin cancer can be painful lesion that itches or burns and large brownish spot with darker speckles. Basal-cell skin cancer (BCC) usually presents as a raised, smooth, pearly bump on

4850-552: The skin . They are due to the development of abnormal cells that have the ability to invade or spread to other parts of the body. It occurs when skin cells grow uncontrollably, forming malignant tumors. The primary cause of skin cancer is prolonged exposure to ultraviolet (UV) radiation from the sun or tanning devices. Skin cancer is the most commonly diagnosed form of cancer in humans. There are three main types of skin cancers: basal-cell skin cancer (BCC), squamous-cell skin cancer (SCC) and melanoma . The first two, along with

4947-462: The ultraviolet protection factor (UPF) represents the ratio of sunburn -causing UV without and with the protection of the fabric, similar to sun protection factor (SPF) ratings for sunscreen . Standard summer fabrics have UPFs around 6, which means that about 20% of UV will pass through. Suspended nanoparticles in stained-glass prevent UV rays from causing chemical reactions that change image colors. A set of stained-glass color-reference chips

SECTION 50

#1732833605403

5044-419: The visible spectrum is conventionally taken as 400 nm, so ultraviolet rays are not visible to humans , although people can sometimes perceive light at shorter wavelengths than this. Insects, birds, and some mammals can see near-UV (NUV), i.e., slightly shorter wavelengths than what humans can see. Ultraviolet rays are usually invisible to most humans. The lens of the human eye blocks most radiation in

5141-627: The EUV spectrum is set by a prominent He spectral line at 30.4 nm. EUV is strongly absorbed by most known materials, but synthesizing multilayer optics that reflect up to about 50% of EUV radiation at normal incidence is possible. This technology was pioneered by the NIXT and MSSTA sounding rockets in the 1990s, and it has been used to make telescopes for solar imaging. See also the Extreme Ultraviolet Explorer satellite . Some sources use

5238-431: The Sun, are absorbed by oxygen and generate the ozone in the ozone layer when single oxygen atoms produced by UV photolysis of dioxygen react with more dioxygen. The ozone layer is especially important in blocking most UVB and the remaining part of UVC not already blocked by ordinary oxygen in air. Ultraviolet absorbers are molecules used in organic materials ( polymers , paints , etc.) to absorb UV radiation to reduce

5335-557: The UV spectrum. Sensitive UV photomultipliers are available. Spectrometers and radiometers are made for measurement of UV radiation. Silicon detectors are used across the spectrum. Vacuum UV, or VUV, wavelengths (shorter than 200 nm) are strongly absorbed by molecular oxygen in the air, though the longer wavelengths around 150–200 nm can propagate through nitrogen . Scientific instruments can, therefore, use this spectral range by operating in an oxygen-free atmosphere (pure nitrogen, or argon for shorter wavelengths), without

5432-674: The UV was greater than 380 nm. Other types of car windows can reduce transmission of UV that is greater than 335 nm. Fused quartz , depending on quality, can be transparent even to vacuum UV wavelengths. Crystalline quartz and some crystals such as CaF 2 and MgF 2 transmit well down to 150 nm or 160 nm wavelengths. Wood's glass is a deep violet-blue barium-sodium silicate glass with about 9% nickel(II) oxide developed during World War I to block visible light for covert communications. It allows both infrared daylight and ultraviolet night-time communications by being transparent between 320 nm and 400 nm and also

5529-827: The UVA spectrum. The rated wavelength is the peak wavelength that the LEDs put out, but light at both higher and lower wavelengths are present. The cheaper and more common 395 nm UV LEDs are much closer to the visible spectrum, and give off a purple color. Other UV LEDs deeper into the spectrum do not emit as much visible light. LEDs are used for applications such as UV curing applications, charging glow-in-the-dark objects such as paintings or toys, and lights for detecting counterfeit money and bodily fluids. UV LEDs are also used in digital print applications and inert UV curing environments. Power densities approaching 3 W/cm (30 kW/m ) are now possible, and this, coupled with recent developments by photo-initiator and resin formulators, makes

5626-481: The UVC band at 253.7 nm and 185 nm due to the mercury within the lamp, as well as some visible light. From 85% to 90% of the UV produced by these lamps is at 253.7 nm, whereas only 5–10% is at 185 nm. The fused quartz tube passes the 253.7 nm radiation but blocks the 185 nm wavelength. Such tubes have two or three times the UVC power of a regular fluorescent lamp tube. These low-pressure lamps have

5723-581: The beginning of the UVB band at 315 nm, and rapidly increasing to 300 nm. The skin and eyes are most sensitive to damage by UV at 265–275 nm, which is in the lower UVC band. At still shorter wavelengths of UV, damage continues to happen, but the overt effects are not as great with so little penetrating the atmosphere. The WHO -standard ultraviolet index is a widely publicized measurement of total strength of UV wavelengths that cause sunburn on human skin, by weighting UV exposure for action spectrum effects at

5820-495: The body, palliative care may be used to improve quality of life. Melanoma has one of the higher survival rates among cancers, with over 86% of people in the UK and more than 90% in the United States surviving more than 5 years . Skin cancer is the most common form of cancer, globally accounting for at least 40% of cancer cases. The most common type is nonmelanoma skin cancer, which occurs in at least 2–3 million people per year. This

5917-403: The body. The skin graft is sutured to the edges of the defect, and a bolster dressing is placed atop the graft for seven to ten days, to immobilize the graft as it heals in place. There are two forms of skin grafting: split thickness and full thickness. In a split thickness skin graft, a shaver is used to shave a layer of skin from the abdomen or thigh. The donor site regenerates skin and heals over

SECTION 60

#1732833605403

6014-459: The case of an elderly frail man with multiple complicating medical problems, a difficult to excise basal-cell cancer of the nose might warrant radiation therapy (slightly lower cure rate) or no treatment at all. Topical chemotherapy might be indicated for large superficial basal-cell carcinoma for good cosmetic outcome, whereas it might be inadequate for invasive nodular basal-cell carcinoma or invasive squamous-cell carcinoma . In general, melanoma

6111-403: The colored glow that many substances give off when exposed to UV light. UVA / UVB emitting bulbs are also sold for other special purposes, such as tanning lamps and reptile-husbandry. Shortwave UV lamps are made using a fluorescent lamp tube with no phosphor coating, composed of fused quartz or vycor , since ordinary glass absorbs UVC. These lamps emit ultraviolet light with two peaks in

6208-526: The development of solar-blind devices has been an important area of research. Wide-gap solid-state devices or vacuum devices with high-cutoff photocathodes can be attractive compared to silicon diodes. Extreme UV (EUV or sometimes XUV) is characterized by a transition in the physics of interaction with matter. Wavelengths longer than about 30 nm interact mainly with the outer valence electrons of atoms, while wavelengths shorter than that interact mainly with inner-shell electrons and nuclei. The long end of

6305-444: The discussions of basal-cell carcinoma and squamous-cell carcinoma . Mohs' micrographic surgery ( Mohs surgery ) is a technique used to remove the cancer with the least amount of surrounding tissue and the edges are checked immediately to see if tumor is found. This provides the opportunity to remove the least amount of tissue and provide the best cosmetically favorable results. This is especially important for areas where excess skin

6402-448: The disease process is mutation in gene PTCH1 that plays an important role in the Sonic hedgehog signaling pathway. Diagnosis is by biopsy and histopathological examination . Non-invasive skin cancer detection methods include photography, dermatoscopy, sonography, confocal microscopy , Raman spectroscopy, fluorescence spectroscopy, terahertz spectroscopy, optical coherence tomography,

6499-577: The distinction of "hard UV" and "soft UV". For instance, in the case of astrophysics , the boundary may be at the Lyman limit (wavelength 91.2 nm, the energy needed to ionise a hydrogen atom from its ground state), with "hard UV" being more energetic; the same terms may also be used in other fields, such as cosmetology , optoelectronic , etc. The numerical values of the boundary between hard/soft, even within similar scientific fields, do not necessarily coincide; for example, one applied-physics publication used

6596-433: The elements and from predators , with some animals having features such as spines or camouflage serving exclusively as anti-predator adaptations . Many animals supplement the protection afforded by their physiology by burrowing or otherwise adopting habitats or behaviors that insulate them from potential sources of harm. Humans originally began wearing clothing and building shelters in prehistoric times for protection from

6693-607: The elements. Both humans and animals are also often concerned with the protection of others, with adult animals being particularly inclined to seek to protect their young from elements of nature and from predators. In the human sphere of activity, the concept of protection has been extended to nonliving objects, including technological systems such as computers, and to intangible things such as intellectual property , beliefs, and economic systems. Humans seek to protect locations of historical and cultural significance through historic preservation efforts, and are also concerned with protecting

6790-463: The emitting sources in UV spectroscopy equipment for chemical analysis. Other UV sources with more continuous emission spectra include xenon arc lamps (commonly used as sunlight simulators), deuterium arc lamps , mercury-xenon arc lamps , and metal-halide arc lamps . The excimer lamp , a UV source developed in the early 2000s, is seeing increasing use in scientific fields. It has the advantages of high-intensity, high efficiency, and operation at

6887-575: The entire UV range. The nitrogen gas laser uses electronic excitation of nitrogen molecules to emit a beam that is mostly UV. The strongest ultraviolet lines are at 337.1 nm and 357.6 nm in wavelength. Another type of high-power gas lasers are excimer lasers . They are widely used lasers emitting in ultraviolet and vacuum ultraviolet wavelength ranges. Presently, UV argon-fluoride excimer lasers operating at 193 nm are routinely used in integrated circuit production by photolithography . The current wavelength limit of production of coherent UV

6984-500: The environment from damage caused by human activity, and with protecting the Earth as a whole from potentially harmful objects from space. Protection of technological systems is often symbolized by the use of a padlock icon , such as "🔒", or a padlock image. Ultraviolet light Ultraviolet radiation , also known as simply UV , is electromagnetic radiation of wavelengths of 10–400 nanometers , shorter than that of visible light , but longer than X-rays . UV radiation

7081-482: The expansion of LED cured UV materials likely. UVC LEDs are developing rapidly, but may require testing to verify effective disinfection. Citations for large-area disinfection are for non-LED UV sources known as germicidal lamps . Also, they are used as line sources to replace deuterium lamps in liquid chromatography instruments. Gas lasers , laser diodes , and solid-state lasers can be manufactured to emit ultraviolet rays, and lasers are available that cover

7178-582: The eye when operating. Incandescent black lights are also produced, using a filter coating on the envelope of an incandescent bulb that absorbs visible light ( see section below ). These are cheaper but very inefficient, emitting only a small fraction of a percent of their power as UV. Mercury-vapor black lights in ratings up to 1 kW with UV-emitting phosphor and an envelope of Wood's glass are used for theatrical and concert displays. Black lights are used in applications in which extraneous visible light must be minimized; mainly to observe fluorescence ,

7275-544: The ground right into early summer and sun positions even at zenith are low, are particularly at risk. Skin, the circadian system, and the immune system can also be affected. The differential effects of various wavelengths of light on the human cornea and skin are sometimes called the "erythemal action spectrum". The action spectrum shows that UVA does not cause immediate reaction, but rather UV begins to cause photokeratitis and skin redness (with lighter skinned individuals being more sensitive) at wavelengths starting near

7372-459: The highest rates of melanoma in the world. The three main types of skin cancer have become more common in the last 20 to 40 years, especially regions where the population is predominantly White. There are three main types of skin cancer: basal-cell skin cancer (basal-cell carcinoma) (BCC), squamous-cell skin cancer (squamous-cell carcinoma) (SCC) and malignant melanoma . Basal-cell carcinomas are most commonly present on sun-exposed areas of

7469-408: The lack of suitable gas / vapor cell window materials above the lithium fluoride cut-off wavelength limit the tuning range to longer than about 110 nm. Tunable V‑UV wavelengths down to 75 nm was achieved using window-free configurations. Lasers have been used to indirectly generate non-coherent extreme UV (E‑UV) radiation at 13.5 nm for extreme ultraviolet lithography . The E‑UV

7566-498: The least frequent of the three common skin cancers. They frequently metastasize, and can cause death once they spread. Less common skin cancers include: Merkel cell carcinoma , Paget's disease of the breast , atypical fibroxanthoma, porocarcinoma , spindle cell tumors, sebaceous carcinomas , microcystic adnexal carcinoma , keratoacanthoma , and skin sarcomas , such as angiosarcoma , dermatofibrosarcoma protuberans , Kaposi's sarcoma , leiomyosarcoma . BCC and SCC often carry

7663-419: The longer infrared and just-barely-visible red wavelengths. Its maximum UV transmission is at 365 nm, one of the wavelengths of mercury lamps . A black light lamp emits long-wave UVA radiation and little visible light. Fluorescent black light lamps work similarly to other fluorescent lamps , but use a phosphor on the inner tube surface which emits UVA radiation instead of visible light. Some lamps use

7760-568: The minimum energy required to ionize atoms . Although long-wavelength ultraviolet is not considered an ionizing radiation because its photons lack sufficient energy, it can induce chemical reactions and cause many substances to glow or fluoresce . Many practical applications, including chemical and biological effects, are derived from the way that UV radiation can interact with organic molecules. These interactions can involve absorption or adjusting energy states in molecules, but do not necessarily involve heating. Short-wave ultraviolet light

7857-473: The most common type of skin cell. As such, sunlight therapy can be a candidate for treatment of conditions such as psoriasis and exfoliative cheilitis , conditions in which skin cells divide more rapidly than usual or necessary. In humans, excessive exposure to UV radiation can result in acute and chronic harmful effects on the eye's dioptric system and retina . The risk is elevated at high altitudes and people living in high latitude areas where snow covers

7954-421: The multispectral imaging technique, thermography, electrical bio-impedance, tape stripping and computer-aided analysis. Dermatoscopy may be useful in diagnosing basal cell carcinoma in addition to skin inspection. There is insufficient evidence that optical coherence tomography (OCT) is useful in diagnosing melanoma or squamous cell carcinoma. OCT may have a role in diagnosing basal cell carcinoma but more data

8051-483: The need for costly vacuum chambers. Significant examples include 193-nm photolithography equipment (for semiconductor manufacturing ) and circular dichroism spectrometers. Technology for VUV instrumentation was largely driven by solar astronomy for many decades. While optics can be used to remove unwanted visible light that contaminates the VUV, in general, detectors can be limited by their response to non-VUV radiation, and

8148-457: The periphery, becoming more mature to the centre of the tumor masses. Tumor cells transform into keratinized squamous cells and form round nodules with concentric, laminated layers, called "cell nests" or "epithelial/keratinous pearls". The surrounding stroma is reduced and contains inflammatory infiltrate (lymphocytes). Poorly differentiated squamous carcinomas contain more pleomorphic cells and no keratinization . A molecular factor involved in

8245-454: The previous year at the other end of the visible spectrum. The simpler term "chemical rays" was adopted soon afterwards, and remained popular throughout the 19th century, although some said that this radiation was entirely different from light (notably John William Draper , who named them "tithonic rays" ). The terms "chemical rays" and "heat rays" were eventually dropped in favor of ultraviolet and infrared radiation , respectively. In 1878,

8342-526: The risk of sunburns but this is much less than the protection provided by sunscreen. A meta-analysis of skin cancer prevention in high risk individuals found evidence that topical application of T4N5 liposome lotion reduced the rate of appearance of basal cell carcinomas in people with xeroderma pigmentosum , and that acitretin taken by mouth may have a skin protective benefit in people following kidney transplant . A paper published in January 2022 showed that

8439-502: The risks and benefits of sun exposure and is also implicated in issues such as fluorescent lamps and health . Getting too much sun exposure can be harmful, but in moderation, sun exposure is beneficial. UV (specifically, UVB) causes the body to produce vitamin D , which is essential for life. Humans need some UV radiation to maintain adequate vitamin D levels. According to the World Health Organization: There

8536-462: The same way as the visible blue light from those parts of the sky. UVB also plays a major role in plant development, as it affects most of the plant hormones. During total overcast, the amount of absorption due to clouds is heavily dependent on the thickness of the clouds and latitude, with no clear measurements correlating specific thickness and absorption of UVA and UVB. The shorter bands of UVC, as well as even more-energetic UV radiation produced by

8633-590: The size, shape, color or elevation of a mole. Other signs are the appearance of a new mole during adulthood or pain, itching, ulceration, redness around the site, or bleeding at the site. An often-used mnemonic is "ABCDE", where A is for "asymmetrical", B for "borders" (irregular: "Coast of Maine sign"), C for "color" (variegated), D for "diameter" (larger than 6 mm – the size of a pencil eraser) and E for "evolving." Merkel cell carcinomas are most often rapidly growing, non-tender red, purple or skin colored bumps that are not painful or itchy. They may be mistaken for

8730-406: The skin, especially the face. They rarely metastasize and rarely cause death. They are easily treated with surgery or radiation. Squamous-cell skin cancers are also common, but much less common than basal-cell cancers. They metastasize more frequently than BCCs. Even then, the metastasis rate is quite low, with the exception of SCC of the lip or ear, and in people who are immunosuppressed. Melanoma are

8827-428: The skin, if applied in too little quantity and too infrequently. However, the researchers add that newer creams often do not contain these specific compounds, and that the combination of other ingredients tends to retain the compounds on the surface of the skin. They also add that frequent re-application reduces the risk of radical formation. There are a variety of different skin cancer symptoms. These include changes in

8924-586: The sterilizing effect of short-wavelength light by killing bacteria was discovered. By 1903, the most effective wavelengths were known to be around 250 nm. In 1960, the effect of ultraviolet radiation on DNA was established. The discovery of the ultraviolet radiation with wavelengths below 200 nm, named "vacuum ultraviolet" because it is strongly absorbed by the oxygen in air, was made in 1893 by German physicist Victor Schumann . The electromagnetic spectrum of ultraviolet radiation (UVR), defined most broadly as 10–400 nanometers, can be subdivided into

9021-438: The sun-exposed skin of the head , neck , torso or shoulders . Sometimes small blood vessels (called telangiectasia ) can be seen within the tumor. Crusting and bleeding in the center of the tumor frequently develops. It is often mistaken for a sore that does not heal. This form of skin cancer is the least deadly, and with proper treatment can be eliminated, often without significant scarring. Squamous-cell skin cancer (SCC)

9118-478: The tunable range of the 4 wave mixing. Difference frequency mixing (i.e., f 1 + f 2 − f 3 ) has an advantage over sum frequency mixing because the phase matching can provide greater tuning. In particular, difference frequency mixing two photons of an Ar F (193 nm) excimer laser with a tunable visible or near IR laser in hydrogen or krypton provides resonantly enhanced tunable V‑UV covering from 100 nm to 200 nm. Practically,

9215-500: The ultraviolet radiation that reaches the Earth's surface, more than 95% is the longer wavelengths of UVA, with the small remainder UVB. Almost no UVC reaches the Earth's surface. The fraction of UVA and UVB which remains in UV radiation after passing through the atmosphere is heavily dependent on cloud cover and atmospheric conditions. On "partly cloudy" days, patches of blue sky showing between clouds are also sources of (scattered) UVA and UVB, which are produced by Rayleigh scattering in

9312-476: The wavelength range of 300–400 nm; shorter wavelengths are blocked by the cornea . Humans also lack color receptor adaptations for ultraviolet rays. Nevertheless, the photoreceptors of the retina are sensitive to near-UV, and people lacking a lens (a condition known as aphakia ) perceive near-UV as whitish-blue or whitish-violet. Under some conditions, children and young adults can see ultraviolet down to wavelengths around 310 nm. Near-UV radiation

9409-643: Was discovered in February 1801 when the German physicist Johann Wilhelm Ritter observed that invisible rays just beyond the violet end of the visible spectrum darkened silver chloride -soaked paper more quickly than violet light itself. He announced the discovery in a very brief letter to the Annalen der Physik and later called them "(de-)oxidizing rays" ( German : de-oxidierende Strahlen ) to emphasize chemical reactivity and to distinguish them from " heat rays ", discovered

#402597