Edenborn is a 2004 science fiction novel by American writer Nick Sagan . It is the sequel to Idlewild , and takes place 18 years after that book. The sequel to this book and the final installment of the trilogy is Everfree .
94-670: In the aftermath of a global plague and the death of all humans, a group of genetically altered posthumans raised in IVR, or Immersive Virtual Reality , are trying to rebuild society by cloning children. They're divided into two ideological factions, the rest being politically indifferent. Vashti and Champagne's group in Munich, Germany, have formed a school in the Nymphenburg Palace for Posthuman children they've created, invulnerable to Black Ep because of genetically boosted immune systems. Due to
188-467: A growing human population , are the primary drivers of this destruction. According to Peter Daszak , the chair of the group who produced the report, "there is no great mystery about the cause of the Covid-19 pandemic or any modern pandemic. The same human activities that drive climate change and biodiversity loss also drive pandemic risk through their impacts on our environment." Proposed policy options from
282-412: A journal app with its iOS 17.2 update, pulling suggestions for entries based on locations the user has visited, music they have listened to, and photos from their photo library alongside prompts. A personal organizer is a form of diary to list actions and tasks for the day, which are recorded in a log, often using symbols to differentiate and categorize items. In free writing, the diarist sets aside
376-449: A memoir , autobiography or biography , it is generally written not with the intention of being published as it stands, but for the author's own use. In recent years, however, there is internal evidence in some diaries (e.g. those of Ned Rorem , Alan Clark , Tony Benn or Simon Gray ) that they are written with eventual publication in mind, with the intention of self-vindication (pre- or posthumous), or simply for profit. By extension,
470-534: A zoonotic origin, having originated in nonhuman primates in Central Africa and transferred to humans in the early 20th century. The most frequent mode of transmission of HIV is through sexual contact with an infected person. There may be a short period of mild, nonspecific symptoms followed by an asymptomatic (but nevertheless infectious) stage called clinical latency - without treatment, this stage can last between 3 and 20 years. The only way to detect infection
564-432: A cause of great concern to health professionals. Every year, nearly half a million new cases of multidrug-resistant tuberculosis (MDR-TB) are estimated to occur worldwide. China and India have the highest rate of MDR-TB. WHO reports that approximately 50 million people worldwide are infected with MDR-TB, with 79 percent of those cases resistant to three or more antibiotics. Extensively drug-resistant tuberculosis ( XDR-TB )
658-454: A death toll of 6.9 million. It is considered likely that the virus will eventually become endemic and, like the common cold, cause less severe disease for most people. HIV/AIDS was first identified as a disease in 1981, and is an ongoing worldwide public health issue. Since then, HIV/AIDS has killed an estimated 40 million people with a further 630,000 deaths annually; 39 million people are currently living with HIV infection. HIV has
752-467: A deserted Britain, and begin a 'last couple on Earth' fantasy. The pair go to an air force base and acquire weaponry. After they accidentally shoot down Pandora over the Mediterranean , they travel to Munich with a rocket launcher. Deuce does not want to actually go through with it, hoping to distract her until they're either caught or Penny sees reason. When Penny tells Deuce to fire the rocket launcher at
846-420: A disease which has caused epidemics in the past may return in the future. It is also possible that little known diseases may become more virulent; in order to encourage research, a number of organisations which monitor global health have drawn up lists of diseases which may have pandemic potential; see table below. Coronavirus diseases are a family of usually mild illnesses in humans, including those such as
940-411: A few minutes each day to write without any constraints, letting thoughts flow freely and allowing the subconscious mind to express itself. Freewriting can unearth hidden thoughts and emotions, fostering self-discovery. A gardening journal helps gardeners improve their efforts over time by providing a historical record of actions taken, the weather and other elements, and the results. A gratitude journal
1034-478: A million fatalities, and the " Spanish flu " of 1918–1920 eventually infected about one-third of the world's population and caused an estimate 50 million fatalities. The Global Influenza Surveillance and Response System is a global network of laboratories that has for purpose to monitor the spread of influenza with the aim to provide WHO with influenza control information. More than two million respiratory specimens are tested by GISRS annually to monitor
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#17331053285401128-431: A novel influenza virus , WHO previously applied a six-stage classification to delineate the process by which the virus moves from the first few infections in humans through to a pandemic. Starting with phase 1 (infections identified in animals only), it moves through phases of increasing infection and spread to phase 6 (pandemic). In February 2020, a WHO spokesperson clarified that the system is no longer in use. In 2014,
1222-460: A number of ethical and political issues which must be considered during a pandemic. These included decisions about who should be prioritised for treatment while resources are scarce; whether or not to make vaccination compulsory; the timing and extent of constraints on individual liberty, how to sanction individuals who do not comply with emergency regulations, and the extent of international collaboration and resource sharing. The basic strategies in
1316-833: A pandemic involves many countries so international cooperation, data sharing, and collaboration are essential; as is universal access to tests and therapies. Collaboration - In response to the COVID-19 pandemic, WHO established a Pandemic Hub in September 2021 in Berlin, aiming to address weaknesses around the world in how countries detect, monitor and manage public health threats. The Hub's initiatives include using artificial intelligence to analyse more than 35,000 data feeds for indications of emerging health threats, as well as improving facilities and coordination between academic institutions and WHO member countries. Detection - In May 2023, WHO launched
1410-413: A person's experiences, thoughts, and/or feelings, excluding comments on current events outside the writer's direct experience. Someone who keeps a diary is known as a diarist . Diaries undertaken for institutional purposes play a role in many aspects of human civilization, including government records (e.g. Hansard ), business ledgers , and military records . In British English, the word may also denote
1504-480: A preprinted journal format . Today the term is generally employed for personal diaries, normally intended to remain private or to have a limited circulation amongst friends or relatives. The word " journal " may be sometimes used for "diary," but generally a diary has (or intends to have) daily entries (from the Latin word for 'day'), whereas journal-writing can be less frequent. Although a diary may provide information for
1598-517: A press conference on 28 December 2020, Mike Ryan, head of the WHO Emergencies Program, and other officials said the current COVID-19 pandemic is "not necessarily the big one" and "the next pandemic may be more severe." They called for preparation. WHO and the UN have warned the world must tackle the cause of pandemics and not just the health and economic symptoms. There is always a possibility that
1692-468: A retrovirus called BEAR. The Thebes children include Hessa, sixteen-year-old Mu'tazz and fifteen-year-old Haji. Though both camps survived Black Ep, both still work to cure it. The two camps have a short-term exchange program despite their incompatibility and the death of Hessa in a previous exchange. The other three posthumans are either neutral or uninvolved in this debate. Pandora runs infrastructure repair and IVR, computer-generated virtual reality used as
1786-416: A risk of a pandemic. A medical dictionary definition of pandemic is " an epidemic occurring on a scale that crosses international boundaries, usually affecting people on a worldwide scale ". A disease or condition is not a pandemic merely because it is widespread or kills many people; it must also be infectious. For instance, cancer is responsible for many deaths but is not considered a pandemic because
1880-525: A school and hobby for the children in Nymphenburg. Halloween lives alone in North America, and opposes the very idea of repopulating Earth. The only person he'll speak to is Pandora. Fantasia is somewhere in North America as well, even more isolated than Halloween. Haji is included in the exchange with Nymphenburg with two of his siblings, Ngozi and Dalila. Raised without some of the technology they use, Haji
1974-455: A stable number of infected individuals such as recurrences of seasonal influenza are generally excluded as they occur simultaneously in large regions of the globe rather than being spread worldwide. Throughout human history , there have been a number of pandemics of diseases such as smallpox . The Black Death , caused by the Plague , caused the deaths of up to half of the population of Europe in
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#17331053285402068-412: A strong groundwork for volume three". Kirkus Reviews wrote that while the book was not "quite as awe-inspiring" as Idlewild , it is still a "rich fantasia, peopled by painfully real characters." Sally Estes of Booklist called the book "gripping". Andrew Leonard of The New York Times wrote that the book's world "feels fake" and has "little genuine flavor", and also criticised the development of
2162-489: A type of prevention strategy, holding back diseases such as influenza and polio which have caused pandemics in the past, and could do so again if not controlled. Prevention overlaps with preparedness which aims to curtail an outbreak and prevent it getting out of control - it involves strategic planning, data collection and modelling to measure the spread, stockpiling of therapies, vaccines, and medical equipment, as well as public health awareness campaigning. By definition,
2256-530: A way to bring previously unpublished diaries to the attention of historians and other readers, such as the diary of Michael Shiner , an enslaved person in the 19th century who documented his life in Washington, D.C. Web-based services such as Open Diary (started in October 1998) and LiveJournal (January 1999) soon appeared to streamline and automate online publishing , but growth in personal storytelling came with
2350-483: Is a diary of things for which someone is grateful . Keeping a gratitude journal is a popular practice in the field of positive psychology . A sleep diary or sleep log is a tool used in the diagnosis and treatment of sleep disorders or to keep track of dreams had in order to gain insight to the subconscious or for further contemplation. The German Tagebuch ('days-book') is normally rendered as "diary" in English, but
2444-432: Is a massive IVR security breach. Everything is exposed, including Vashti 's logs and evaluations of the girls that reveal a range of mood-suppressing drugs —including sex-drive suppressants—and subliminal codes that the Munich camp use to keep their children in line, as well as the reading of the girls' supposedly secret diaries . Penny's ego is shattered by the revelation that she is considered beneath her sisters. Vashti
2538-509: Is an incomplete list of known epidemics which spread widely enough to merit the title "pandemic". Beginning from the Middle Ages, encounters between European settlers and native populations in the rest of the world often introduced epidemics of extraordinary virulence. Settlers introduced novel diseases which were endemic in Europe, such as smallpox , measles , pertussis .and influenza , to which
2632-427: Is by means of a HIV test. There is no vaccine to prevent HIV infection, but the disease can be held in check by means of antiretroviral therapy . Historical accounts of epidemics are often vague or contradictory in describing how victims were affected. A rash accompanied by a fever might be smallpox, measles, scarlet fever, or varicella , and it is possible that epidemics overlapped, with multiple infections striking
2726-433: Is delighted by it, but feels a certain unease. Vashti monitors all of their dealings and domains in IVR, and has it strictly censored. Vashti also controls the girls through virtual dollars given as pocket money, used to buy things in IVR. Penny, the main character of the Munich base, showns signs of narcissism. She considers herself the best of her siblings, regarding them with either hatred or pity. She also believes she has
2820-672: Is developing a program to condense new vaccine development timelines to 100 days, a third of the time it took to develop a COVID-19 vaccine. CEPI aims to reduce global epidemic and pandemic risk by developing vaccines against known pathogens as well as enabling rapid response to Disease X . In the US, the National Institute of Allergy and Infectious Diseases (NIAID) has developed a Pandemic Preparedness Plan which focuses on identifying viruses of concern and developing diagnostics and therapies (including prototype vaccines) to combat them. Modeling
2914-452: Is furious and the girls are outraged. The attack is traced back to Halloween. However, it was really organized by someone named Deuce, who was also behind the mysterious objects. Meanwhile, Pandora is tracking monkeys in the Amazon in the hopes of discovering how they survived Black Ep. The group captures a primate, but Mu'tazz, a human boy on the expedition, suddenly becomes extremely ill, and
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3008-712: Is important to inform policy decisions. It helps to predict the burden of disease on healthcare facilities, the effectiveness of control measures, projected geographical spread, and timing and extent of future pandemic waves. Public Awareness involves disseminating reliable information, ensuring consistency on message, transparency, and steps to discredit misinformation . Stockpiling involves maintaining strategic stockpiles of emergency supplies such as personal protective equipment, drugs and vaccines, and equipment such as respirators. Many of these items have limited shelf life , so they require stock rotation even though they may be rarely used. The COVID-19 pandemic highlighted
3102-399: Is no longer possible to contain the spread of the disease, management will then move on to the mitigation stage, in which measures are taken to slow the spread of the disease and mitigate its effects on society and the healthcare system. In reality, containment and mitigation measures may be undertaken simultaneously. A key part of managing an infectious disease outbreak is trying to decrease
3196-661: Is often far less. In response to the COVID-19 pandemic, 194 member states of the World Health Organization began negotiations on an International Treaty on Pandemic Prevention, Preparedness and Response , with a requirement to submit a draft of this treaty to the 77th World Health Assembly during its 2024 convention. Further, on 6 May 2024, the White House released an official policy to more safely manage medical research projects involving potentially hazardous pathogens , including viruses and bacteria , that may pose
3290-513: Is the book one writes in, only read by oneself – particularly in adversity. Anne Frank went so far as to address her diary as "Kitty." Friedrich Kellner , a court official in Nazi Germany , thought of his diary as a weapon for any future fight against tyrants and terrorism, and named it 'Mein Widerstand' , My Opposition . Victor Klemperer was similarly concerned with recording for the future
3384-536: The Diaries of Adrian Mole ). Both prompted long-running satirical features in the magazine Private Eye : the former entitled Mrs Wilson's Diary in reference to Mary Wilson , wife of Prime Minister Harold Wilson , the latter entitled The Secret Diary of John Major Aged 47¾ and written as a pastiche of the Adrian Mole diaries from the perspective of the then-Prime Minister John Major . Another famous example of
3478-557: The Greek παν- pan- meaning "all", or "every" and δῆμος demos "people". A common early characteristic of a pandemic is a rapid, sometimes exponential , growth in the number of infections, coupled with a widening geographical spread. WHO utilises different criteria to declare a Public Health Emergency of International Concern (PHEIC), its nearest equivalent to the term pandemic. The potential consequences of an incident are considered, rather than its current status. For example, polio
3572-510: The MIT Media Lab website from 14 November 1994 until 1996. Other early online diarists include Justin Hall , who began eleven years of personal online diary-writing in 1994, Carolyn Burke, who started publishing Carolyn's Diary on 3 January 1995, and Bryon Sutherland, who announced his diary The Semi-Existence of Bryon in a USENET newsgroup on 19 April 1995. The internet has also served as
3666-515: The Smythson company created the first featherweight diary, enabling diaries to be carried about. Many diaries of notable figures have been published and form an important element of autobiographical literature. Samuel Pepys (1633–1703) is the earliest diarist who is well known today; his diaries, preserved in Magdalene College, Cambridge , were first transcribed and published in 1825. Pepys
3760-574: The United Nations ' Intergovernmental Science-Policy Platform on Biodiversity and Ecosystem Services , written by 22 experts in a variety of fields, said the anthropogenic destruction of biodiversity is paving the way to the pandemic era and could result in as many as 850,000 viruses being transmitted from animals—in particular birds and mammals —to humans. The "exponential rise" in consumption and trade of commodities such as meat , palm oil , and metals, largely facilitated by developed nations, and
3854-572: The common cold , that have resulted in outbreaks and pandemics such as the 1889-1890 pandemic , the 2002–2004 SARS outbreak , Middle East respiratory syndrome–related coronavirus and the COVID-19 pandemic . There is widespread concern that members of the coronavirus family, particularly SARS and MERS have the potential to cause future pandemics. Many human coronaviruses have zoonotic origin, their with natural reservoir in bats or rodents, leading to concerns for future spillover events. Following
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3948-690: The indigenous peoples had no immunity. The Europeans infected with such diseases typically carried them in a dormant state , were actively infected but asymptomatic , or had only mild symptoms. Smallpox was the most destructive disease that was brought by Europeans to the Native Americans, both in terms of morbidity and mortality. The first well-documented smallpox epidemic in the Americas began in Hispaniola in late 1518 and soon spread to Mexico. Estimates of mortality range from one-quarter to one-half of
4042-647: The medieval Near East , Arabic diaries were written from before the 10th century. The earliest surviving diary of this era which most resembles the modern diary was that of Abu Ali ibn al-Banna in the 11th century. His diary is the earliest known to be arranged in order of date ( ta'rikh in Arabic), very much like modern diaries. The precursors of the diary in the modern sense include daily notes of medieval mystics , concerned mostly with inward emotions and outward events perceived as spiritually important (e.g. Elizabeth of Schönau , Agnes Blannbekin , and perhaps also, in
4136-534: The 14th century. The term pandemic had not been used then, but was used for later epidemics, including the 1918 H1N1 influenza A pandemic—more commonly known as the Spanish flu —which is the deadliest pandemic in history . The most recent pandemics include the HIV/AIDS pandemic , the 2009 swine flu pandemic and the COVID-19 pandemic . Almost all these diseases still circulate among humans though their impact now
4230-518: The 19th century. As examples, the Grasmere Journal of Dorothy Wordsworth (1771–1855) was published in 1897; the journals of Fanny Burney (1752–1840) were published in 1889; the diaries of Henry Crabb Robinson (1776–1867) were published in 1869. Among important U.S. Civil War diaries are those of George Templeton Strong , a New York City lawyer, and Mary Chesnut , the wife of a Confederate officer. The diary of Jemima Condict , living in
4324-531: The German occupation of Amsterdam in the 1940s. Otto Frank edited his daughter's diary and arranged for its publication after the war. Many edits were made before the diary was published in other countries. This was due to sexually explicit material, which also led to some libraries banning the book. The writing of diaries was also often practiced from the 20th century onwards as a conscious act of self-exploration (of greater or lesser sincerity) – examples being
4418-598: The International Pathogen Surveillance Network (IPSN) (hosted by the Pandemic Hub) aiming to detect and respond to disease threats before they become epidemics and pandemics, and to optimize routine disease surveillance. The network provides a platform to connect countries, improving systems for collecting and analysing samples of potentially harmful pathogens . Therapies and Vaccines - The Coalition for Epidemic Preparedness Innovations (CEPI)
4512-765: The United States Centers for Disease Control and Prevention (CDC) introduced a framework for characterising the progress of an influenza pandemic titled the Pandemic Intervals Framework . The six intervals of the framework are as follows: At the same time, the CDC adopted the Pandemic Severity Assessment Framework (PSAF) to assess the severity of influenza pandemics. The PSAF rates the severity of an influenza outbreak on two dimensions: clinical severity of illness in infected persons; and
4606-452: The ability to "hex" people, crediting herself with the injury of her sister. When she hears that Pandora has become overworked and may need an assistant, she puts all her energy into getting the position, even bribing or blackmailing her sisters to convince Pandora to hire her. Penny wants to be "queen of the inside" by controlling IVR, thereby controlling her sisters. Many small items with no history or sender keep ending up in IVR. Penny finds
4700-537: The area of what is now West Orange, New Jersey , includes local observations of the American Revolutionary War . Since the 19th century the publication of diaries by their authors has become commonplace – notably amongst politicians seeking justification but also amongst artists and litterateurs of all descriptions. Amongst late 20th-century British published political diaries, those of Richard Crossman , Tony Benn and Alan Clark are representative,
4794-424: The characters, writing that only one of the characters "feels nastily fleshed out". Pandemic A pandemic ( / p æ n ˈ d ɛ m ɪ k / pan- DEM -ik ) is an epidemic of an infectious disease that has a sudden increase in cases and spreads across a large region, for instance multiple continents or worldwide, affecting a substantial number of individuals. Widespread endemic diseases with
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#17331053285404888-466: The children, supplies, and gardening. The Nymphenburg children include fifteen-year-old Penelope, Sloane, and Tomi. Isaac's group is based in Luxor, Egypt, which he has renamed Thebes, and is structured more like a traditional family. His children consist of both females and males, and are unaltered humans. Thebes is Sufi Muslim, and a more relaxed environment than Nymphenburg. They're protected from Black Ep by
4982-440: The control of an outbreak are containment and mitigation . Containment may be undertaken in the early stages of the outbreak, including contact tracing and isolating infected individuals to stop the disease from spreading to the rest of the population, other public health interventions on infection control, and therapeutic countermeasures such as vaccinations which may be effective if available. When it becomes apparent that it
5076-565: The diaries of Carl Jung , Aleister Crowley and Anaïs Nin . Among important diaries by 20th-century literary figures are those of Franz Kafka , Edmund Wilson and the French writer Paul Léautaud (1872–1956). The self-reflective Diary: Divine Mercy in My Soul written by Saint Faustina contains accounts of her visions and conversations with Jesus. A strong psychological effect may arise from having an audience for one's self-expression, even if this
5170-533: The diary after correct PIN entry on a secure USB device. With the popularization of mobile apps , diary or journaling apps have become available for iOS and Android . Proponents have cited numerous reasons for journaling using digital applications, including ease and speed of typing, mobile portability, and search capabilities. Digital diaries are also tailored towards shorter-form, in-the-moment writing, similar to user engagement with social media services such as Facebook , Twitter and Instagram . Apple released
5264-427: The disease is not contagious —i.e. easily transmissible—and not even simply infectious . This definition differs from colloquial usage in that it encompasses outbreaks of relatively mild diseases. The World Health Organization (WHO) has a category of Public Health Emergency of International Concern , defined as " an extraordinary event which is determined to constitute a public health risk to other States through
5358-641: The diseases become accepted into people's daily lives and routines, becoming endemic . The transition from pandemic to endemic may be defined based on: An endemic disease is always present in a population, but at a relatively low and predictable level. There may be periodic spikes of infections or seasonality, (e.g. influenza ) but generally the burden on health systems is manageable. Pandemic prevention comprises activities such as anticipatory research and development of therapies and vaccines, as well as monitoring for pathogens and disease outbreaks which may have pandemic potential. Routine vaccination programs are
5452-402: The distribution of these diseases due to the changing geographic range of their vectors, with the potential to cause serious outbreaks in areas where the disease has not previously been known. The other group comprises water-borne diseases such as cholera, dysentery, and typhoid which may increase in prevalence due to changes in rainfall patterns. The October 2020 'era of pandemics' report by
5546-425: The emergence of blogs . While the format first focused on external links and topical commentary, widespread blogging tools were quickly used to create web journals. Recent advances have also been made to enable the privacy of internet diary entries. For example, some diary software now stores entries in an encrypted format, such as 256-bit AES ( Advanced Encryption Standard ) encryption, and others only permit access to
5640-494: The end of the COVID-19 pandemic Public Health Emergency of International Concern deceleration by WHO, WHO Director General Tedros Ghebreyesus stated he would not hesitate to re-declare COVID-19 a PHEIC should the global situation worsen in the coming months or years. Influenza was first described by the Greek physician Hippocrates in 412 BC. Since the Middle Ages, influenza pandemics have been recorded every 10 to 30 years as
5734-776: The epidemic peak, known as " flattening the curve ". This helps decrease the risk of health services being overwhelmed and provides more time for a vaccine and treatment to be developed. A broad group of non-pharmaceutical interventions may be taken to manage the outbreak. In a flu pandemic, these actions may include personal preventive measures such as hand hygiene, wearing face-masks, and self-quarantine; community measures aimed at social distancing such as closing schools and canceling mass gatherings; community engagement to encourage acceptance and participation in such interventions; and environmental measures such as cleaning of surfaces. Another strategy, suppression , requires more extreme long-term non-pharmaceutical interventions to reverse
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#17331053285405828-517: The even earlier work To Myself ( Τὰ εἰς ἑαυτόν ), today known as the Meditations , written in Greek by the Roman emperor Marcus Aurelius in the second half of the 2nd century AD, already displays many characteristics of a diary. Pillowbooks of Japanese court ladies and Asian travel journals offer some aspects of this genre of writing, although they rarely consist exclusively of diurnal records. In
5922-402: The fact that females have a slightly stronger resistance to Black Ep and Vashti's belief in matriarchy, all the children are female. Nymphenburg is very structured, most of the children's time being rigidly scheduled. Vashti feels that humanity should be improved upon via genetic engineering, and leads most of the scientific aspects of Nymphenburg. Champagne is mostly responsible for taking care of
6016-411: The group rushes to Nymphenburg for medical care. During the flight, Vashti calls Pandora, demanding she confront Halloween. During Pandora and Halloween's conversation, Halloween reveals that he cloned himself shortly after escaping IVR, hoping for the clone to be a better person. However, he did not replicate Halloween's choices, and Hal realized that he was not the same. He pulled him out of IVR when he
6110-434: The headquarters where everyone else is, Deuce refuses. Penny takes the rocket launcher herself and prepares to fire it. Halloween shoots her. Deuce commits suicide, with his idea of his father shattered. In the aftermath, the various leaders realize that all their problems came from division. They all move to Munich, where they begin to build, hopefully, a better world. F&SF reviewer Robert. K. J. Killheffer described
6204-442: The human population. For example, influenza is a rapidly evolving disease which has caused pandemics in the past and has potential to cause future pandemics. WHO collates the findings of 144 national influenza centres worldwide which monitor emerging flu viruses. Virus variants which are assessed as likely to represent a significant risk are identified and can then be incorporated into the next seasonal influenza vaccine program. In
6298-785: The international spread of disease and to potentially require a coordinated international response ". There is a rigorous process underlying this categorization and a clearly defined trajectory of responses. A WHO-sponsored international body, tasked with preparing an international agreement on pandemic prevention, preparedness and response has defined a pandemic as " the global spread of a pathogen or variant that infects human populations with limited or no immunity through sustained and high transmissibility from person to person, overwhelming health systems with severe morbidity and high mortality, and causing social and economic disruptions, all of which require effective national and global collaboration and coordination for its control ". The word comes from
6392-436: The key, she is sympathetic, advising him not to sacrifice himself. Haji is overwhelmed, feeling betrayed by his father and wondering whether he should go through with it. His religion stresses the ultimate path to God as self-annihilation through fana . He wonders if his father's intentions in raising him to believe this were to get him to accept his death. Haji calls Isaac while he's on an expedition with Pandora asking him if he
6486-466: The latter being more indiscreet, in the tradition of the diaries of Chips Channon . In Britain in the field of the arts notable diaries were published by James Lees-Milne , Roy Strong and Peter Hall . Harold Nicolson in the mid-20th century covered both politics and the arts. One of the most famous modern diaries, widely read and translated, is the posthumously published The Diary of a Young Girl by Anne Frank , who wrote it while in hiding during
6580-464: The lost vernacular account of her visions, Beatrice of Nazareth ). From the Renaissance on, some individuals wanted not only to record events, as in medieval chronicles and itineraries, but also to put down their own opinions and express their hopes and fears, without any intention to publish these notes. One of the early preserved examples is the anonymous Journal d'un bourgeois de Paris covering
6674-426: The novel as a "competent but not particularly original [take] on familiar sf scenarios," distinguished from the routine by Sagan's "sympathetic treatment of religious faith." Jon Courtenay Grimwood , writing for The Guardian wrote that the book is "better written and even more tightly plotted" than Idlewild . Publishers Weekly wrote that Sagan's "sharp observations" and "rich imagination" both entertain and "lay
6768-402: The pandemic by reducing the basic reproduction number to less than 1. The suppression strategy, which includes stringent population-wide social distancing, home isolation of cases, and household quarantine, was undertaken by China during the COVID-19 pandemic where entire cities were placed under lockdown; such a strategy may carry with it considerable social and economic costs. For
6862-401: The population of central Mexico. It is estimated that over the 100 years after European arrival in 1492, the indigenous population of the Americas dropped from 60 million to only 6 million, due to a combination of disease, war, and famine. The majority these deaths are attributed to successive waves of introduced diseases such as smallpox, measles, and typhoid fever. In Australia , smallpox
6956-469: The population, in 1875, and in the early 19th century devastated the Great Andamanese population. In Hokkaido , an epidemic of smallpox introduced by Japanese settlers is estimated to have killed 34% of the native Ainu population in 1845. Prevention of future pandemics requires steps to identify future causes of pandemics and to take preventive measures before the disease moves uncontrollably into
7050-469: The possibility of zoonotic infections. The advent of agriculture, and trade between settled groups, made it possible for pathogens to spread widely. As population increased, contact between groups became more frequent. A history of epidemics maintained by the Chinese Empire from 243 B.C. to 1911 A.C. shows an approximate correlation between the frequency of epidemics and the growth of the population. Here
7144-495: The primary cause of pandemics so far, the anthropogenic destruction of the natural world through such activities including deforestation and hunting , is being ignored by world leaders. Diary A diary is a written or audiovisual memorable record, with discrete entries arranged by date reporting on what has happened over the course of a day or other period. Diaries have traditionally been handwritten but are now also often digital . A personal diary may include
7238-555: The report include taxing meat production and consumption, cracking down on the illegal wildlife trade, removing high-risk species from the legal wildlife trade, eliminating subsidies to businesses that are harmful to the natural world, and establishing a global surveillance network. In June 2021, a team of scientists assembled by the Harvard Medical School Center for Health and the Global Environment warned that
7332-486: The same population at once. It is often impossible to know the exact causes of mortality, although ancient DNA studies can sometimes detect residues of certain pathogens. It is assumed that, prior to the Neolithic Revolution around 10,000 BC, disease outbreaks were limited to a single family or clan, and did not spread widely before dying out. The domestication of animals increased human-animal contact, increasing
7426-449: The spread and evolution of influenza viruses through a network of about 150 laboratories in 114 countries representing 91% of the world's population. Antibiotic-resistant microorganisms, which sometimes are referred to as " superbugs ", may contribute to the re-emergence of diseases with pandemic potential that are currently well controlled. For example, cases of tuberculosis that are resistant to traditionally effective treatments remain
7520-561: The term diary is also used to mean a printed publication of a written diary; and may also refer to other terms of journal including electronic formats (e.g. blogs ). The word ' diary ' comes from the Latin diarium ("daily allowance," from dies , "day"). The word 'journal' comes from the same root ( diurnus , "of the day") through the Old French jurnal (the modern French for 'day' being jour ). The earliest recorded use of
7614-572: The term encompasses workbooks or working journals as well as diaries proper. For example, the notebooks of the Austrian writer Robert Musil and of the German-Swiss artist Paul Klee are called Tagebücher . A travel journal, travel diary, or road journal, is the documentation of a journey or series of journeys. A war diary is a regularly updated official record of a military unit's administration and activities during wartime maintained by an officer in
7708-530: The transmissibility of the infection in the population. This tool was not applied during the COVID-19 pandemic. SARS-CoV-2 , a new strain of coronavirus , was first detected in the city of Wuhan, Hubei Province , China, in December 2019. The outbreak was characterized as a Public Health Emergency of International Concern (PHEIC) between January 2020 and May 2023 by WHO. The number of people infected with COVID-19 has reached more than 767 million worldwide, with
7802-424: The tyrannies and hypocrisies of Nazi Germany and of its East German successor state in his diaries. However in these cases, the authors didn't anticipate publication. As internet access became commonly available, many people adopted it as another medium in which to chronicle their lives with the added dimension of an audience. The first online diary is thought to be Claudio Pinhanez's Open Diary , published at
7896-477: The unit. Such diaries can form an important source of historical information, for example about long and complex battles in World War I . There are numerous examples of fictional diaries. One of the earliest printed fictional diaries was the humorous Diary of a Nobody by George Grossmith and his brother Weedon. 20th-century examples include radio broadcasts (e.g. Mrs. Dale's Diary ) and published books (e.g.
7990-417: The virus mutates to evade immunity. Influenza is an endemic disease , with a fairly constant number of cases which vary seasonally and can, to a certain extent, be predicted. In a typical year, 5–15% of the population contracts influenza. There are 3–5 million severe cases annually, with up to 650,000 respiratory-related deaths globally each year. The 1889–1890 pandemic is estimated to have caused around
8084-592: The word 'diary' to refer to a book in which a daily record was written was in Ben Jonson 's comedy Volpone in 1605. The earliest known book resembling a diary is the Diary of Merer , an ancient Egyptian logbook whose author described the transportation of limestone from Tura to Giza , likely to clad the outside of the Great Pyramid . The oldest extant diaries come from Middle Eastern and East Asian cultures, although
8178-630: The years 1405–1449, giving subjective commentaries on current events. Famous 14th to 16th century Renaissance examples, which appeared much later as books, were the diaries by the Florentines Buonaccorso Pitti and Gregorio Dati and the Venetian Marino Sanuto the Younger . These diaries include records of even less important everyday occurrences together with much reflection, emotional experience and personal impressions. In 1908,
8272-459: The yin half of a yin-yang symbol and Haji finds a key. Tomi, his friend, recognizes it as the key to the cryonics lab where she assists Vashti. Tomi sneaks him in, realizing that he is a clone of IVR programmer Dr. James Hyoguchi. She shows Haji a recording from James telling him to "download" James' mapped brain, destroying himself in the process. Haji is terrified, and as the disc ends Vashti finds him and Tomi. After repeatedly asking him who sent him
8366-464: Was declared a PHEIC in 2014 even though only 482 cases were reported globally in the previous year; this was justified by concerns that polio might break out of its endemic areas and again become a significant health threat globally. The PHEIC status of polio is reviewed regularly and is ongoing, despite the small number of cases annually. The end of a pandemic is more difficult to delineate. Generally, past epidemics & pandemics have faded out as
8460-665: Was amongst the first who took the diary beyond mere business transaction notation, into the realm of the personal. Pepys' contemporary John Evelyn also kept a notable diary, and their works are among the most important primary sources for the English Restoration period, and consist of eyewitness accounts of many great events, such as the Great Plague of London , and the Great Fire of London . The practice of posthumous publication of diaries of literary and other notables began in
8554-862: Was first identified in Africa in 2006 and subsequently discovered to exist in 49 countries. During 2021 there were estimated to be around 25,000 cases XDR-TB worldwide. In the past 20 years, other common bacteria including Staphylococcus aureus , Serratia marcescens and Enterococcus , have developed resistance to a wide range of antibiotics . Antibiotic-resistant organisms have become an important cause of healthcare-associated ( nosocomial ) infections. There are two groups of infectious disease that may be affected by climate change. The first group are vector-borne diseases which are transmitted via insects such as mosquitos or ticks. Some of these diseases, such as malaria , yellow fever , and dengue fever , can have potentially severe health consequences. Climate can affect
8648-465: Was five years old, named him Deuce, and raised him as his son. Halloween largely approves of Deuce exposing Vashti and Champagne. Deuce, Halloween, and Pandora agree to fly Deuce to Munich, Deuce and Halloween mostly seeing it as an opportunity for Deuce to meet new people, but Vashti intending to "make an example of him". Halloween travels to Munich to find his son, and makes a certain amount of peace with his former classmates. Deuce and Penelope go to
8742-444: Was in fact designed to be a conduit for James. Isaac tells him that this is not the case, and that he should disregard the disc. In a diary entry, Penny reveals that Hessa's death was caused by her switching pills out with laxatives as a prank. When her plan to become Pandora's assistant fails, she flies into a rage, making a list of people she wants revenge upon. Just after Haji calls his father and Penny makes out her hit list, there
8836-576: Was introduced by European settlers in 1789 devastating the Australian Aboriginal population, killing an estimated 50% of those infected with the disease during the first decades of colonisation. In the early 1800s, measles, smallpox and intertribal warfare killed an estimated 20,000 New Zealand Māori . In 1848–49, as many as 40,000 out of 150,000 Hawaiians are estimated to have died of measles , whooping cough and influenza . Measles killed more than 40,000 Fijians , approximately one-third of
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