The Platine Wars is a term used by Brazilian historiography to refer to a series of diplomatic and military conflicts along the 19th century between the Empire of Brazil and neighbouring countries in the Río de la Plata Basin .
171-564: These conflicts began in 1816, due to the intention of Prince Regent John of annexing the Banda Oriental (modern-day Uruguay ) and pushing the Brazilian border to the left bank of the River Plate estuary. The most notable wars in this period include: This military -related article is a stub . You can help Misplaced Pages by expanding it . This article about the history of Argentina
342-508: A direct bandgap , and can be used in laser diodes and LEDs to convert electrical energy directly into light. After World War I , the United States built a stockpile of 20,000 tons of weaponized lewisite (ClCH=CHAsCl 2 ), an organoarsenic vesicant (blister agent) and lung irritant. The stockpile was neutralized with bleach and dumped into the Gulf of Mexico in the 1950s. During
513-568: A tetrahedral structure in which each atom is bound to each of the other three atoms by a single bond. This unstable allotrope, being molecular, is the most volatile, least dense, and most toxic. Solid yellow arsenic is produced by rapid cooling of arsenic vapor, As 4 . It is rapidly transformed into grey arsenic by light. The yellow form has a density of 1.97 g/cm . Black arsenic is similar in structure to black phosphorus . Black arsenic can also be formed by cooling vapor at around 100–220 °C and by crystallization of amorphous arsenic in
684-547: A wood preservative . In the 1930s, a process of treating wood with chromated copper arsenate (also known as CCA or Tanalith ) was invented, and for decades, this treatment was the most extensive industrial use of arsenic. An increased appreciation of the toxicity of arsenic led to a ban of CCA in consumer products in 2004, initiated by the European Union and United States. However, CCA remains in heavy use in other countries (such as on Malaysian rubber plantations). Arsenic
855-527: A British fleet anchored in the port. From aboard the Royal Navy ship Windsor Castle , he reprimanded his son, deposed him from command of the army, and ordered him to release his political prisoners. Miguel was exiled. With the defeat of the rebellion, both liberals and absolutists came out into the streets to celebrate the survival of the legitimate government. On 14 May, the King returned to Bemposta, reconstituted
1026-505: A French ambassador of the time painted him in unfavorable colors, seeing him as hesitant and dim. The record of this period of his life is too vague for historians to form any definitive picture. Little is known of the substance of his education. He surely received instruction in religion, law, French, and etiquette, and would presumably have learned history through reading the works of Duarte Nunes de Leão and João de Barros . In 1785, Henrique de Meneses, 3rd Marquis of Louriçal , arranged
1197-620: A French army was approaching, and on 16 November, a British squadron arrived in the port of Lisbon with a force of seven thousand men with orders either to escort the royal family to Brazil or, if the government surrendered to France, to attack and conquer the Portuguese capital. The court was divided between Francophiles and Anglophiles, and after anguished consideration under pressure from both sides, John decided to accept British protection and leave for Brazil. The invading army led by Jean-Andoche Junot advanced with some difficulty, arriving at
1368-508: A Portuguese colony, in the words of Caio Prado, Jr. "Establishing in Brazil the seat of a monarchy, the regent ipso facto abolished the colonial regime under which the country had lived until then. All the characteristics of that [colonial] regime disappeared, the only remaining part of the colonial situation was to be under a foreign government. One after another, the old workings of colonial administration were abolished and replaced by those of
1539-614: A basis for a new charter to replace the constitution. John's alliance with Infante Miguel did not bear fruit. Influenced as always by his mother, Miguel led the April Revolt or Abrilada by the Lisbon military garrison on 29 April 1824. The revolt started on the pretext of crushing the Freemasons and defending the King from threats of death that the Masons has supposedly made against him, but John
1710-425: A broad attack on historical knowledge", in contrast to director Carla Camurati 's stated intent "to produce a cinematic narrative that would constitute a type of historical novel with pedagogic function and, at the same time, would offer the viewer knowledge of the past and would help, as a people, to think about the present. It does not offer new historical knowledge to the viewer, even if one were to treat history as
1881-439: A clever king who was able to balance many competing interests. João Maria José Francisco Xavier de Paula Luís António Domingos Rafael was born 13 May 1767 during the reign of his maternal grandfather, King Dom Joseph I of Portugal . He was the second son of the King's eldest daughter and heir, Dona Maria, Princess of Brazil (later Queen Dona Maria I) and Infante Peter of Portugal (later King Dom Peter III). Peter
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#17328527431682052-483: A display of pomp, and the distribution of gold bars and diamonds among the nobility. Dom Pedro married Archduchess Maria Leopoldina of Austria , daughter of Emperor Francis I , in 1817. The Emperor and his minister Metternich considered the alliance "an advantageous pact between Europe and the New World," strengthening the monarchical regime in both hemispheres and granting Austria a new sphere of influence. Meanwhile,
2223-490: A distorted octahedral complex, with the three atoms in the same double-layer being slightly closer than the three atoms in the next. This relatively close packing leads to a high density of 5.73 g/cm . Grey arsenic is a semimetal , but becomes a semiconductor with a bandgap of 1.2–1.4 eV if amorphized . Grey arsenic is also the most stable form. Yellow arsenic is soft and waxy, and somewhat similar to tetraphosphorus ( P 4 ). Both have four atoms arranged in
2394-410: A farm near the beach of Botafogo , continuing her habit of living apart from her husband. The city, which at that time had about 70,000 inhabitants, saw itself transformed overnight. The additional populace, full of new requirements, imposed a new organization in the supply of food and other consumer goods, including luxury items. It took years for the Portuguese to settle in, causing years of chaos in
2565-404: A historiography that insists on judging the King, despite the transformations that discipline experienced over the course of the twentieth century". In governing, John always depended on strong auxiliaries. Prominent among these were Rodrigo de Sousa Coutinho, 1st Count of Linhares ; António de Araújo e Azevedo, 1st Count of Barca ; and Tomás Antônio de Vila Nova Portugal. They may be considered
2736-465: A lasting mark, especially in Brazil, where he helped to create numerous institutions and services that laid a foundation for national autonomy, and many historians consider him to be a true mastermind of the modern Brazilian state. John's contemporaries viewed him as a kind and benevolent king, although later generations of Portuguese and Brazilians have made him the subject of frequent caricature. However, in recent decades his reputation has been restored as
2907-562: A lot with the Infanta. The way these things go, I think six years from now. Better that she be a bit more grown up than when she came." The consummation waited until 1790. In 1793, Carlota Joaquina gave birth to the first of nine children: Teresa, Princess of Beira . The death of John's older brother, José, on 11 September 1788, left John as the heir apparent to the throne, with the titles of Prince of Brazil and Duke of Braganza. Great things had been hoped for from José, who associated himself with
3078-410: A lot, but for all that I cannot love her equally." John's young bride was not inclined to docility, requiring at times the correction of Queen Maria herself. In addition, the difference in their ages (John being 17 years old) made him uncomfortable and anxious. Because Carlota Joaquina was so young, the marriage had not been consummated, and John wrote, "Here's to the arrival of the time when I shall play
3249-517: A major source of arsenic contamination of groundwater in regions with high levels of naturally-occurring arsenic minerals. Synthetic arsenates include Scheele's Green (cupric hydrogen arsenate, acidic copper arsenate), calcium arsenate , and lead hydrogen arsenate . These three have been used as agricultural insecticides and poisons . The protonation steps between the arsenate and arsenic acid are similar to those between phosphate and phosphoric acid . Unlike phosphorous acid , arsenous acid
3420-522: A manner as not to imply that the King had been coerced, but in fact a new political environment had already been established. A constitution had been drafted, and the King was required to swear loyalty to it on 1 October 1822. It called for him to surrender various prerogatives. The Queen refused to follow her husband in agreeing to this, and thus was dispossessed of her political rights and deposed of her title as queen. Meanwhile, John lost out in Brazil as well. His son Pedro, opting to stay in that country, led
3591-508: A marriage between John and Infanta Carlota Joaquina of Spain , daughter of the Prince and Princess of Asturias (later King Charles IV and Queen Maria Luisa ). Fearing a new Iberian Union , some in the Portuguese court viewed John's marriage to a Spanish infanta unfavorably. Carlota Joaquina endured four days of testing by the Portuguese ambassadors before the marriage pact was confirmed. Because John and Carlota Joaquina were related and because of
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#17328527431683762-530: A meeting in Rio to choose deputies to the Constituent Cortes, but the following day, protests in the plaza were put down violently. In Brazil, the general opinion was that the King's return to Portugal could mean loss of the autonomy Brazil had gained and a return to its prior colonial status. Under pressure, John tried to find a middle way by sending his son Prince Pedro to Lisbon to grant a constitution and establish
3933-462: A military corps that had been disbanded by the liberals, receiving the applause of the militia. the King personally went to Vila Franca to better administer the uprising, ultimately returning to Lisbon in triumph. The political climate was undecided, and even the staunchest defenders of liberalism feared to take a strong stand on its behalf. Before its dissolution, the Cortes protested against any change in
4104-462: A mix of nobles and commoners. According to painter Henry L’Evêque, "the Prince, accompanied by a Secretary of State, a Chamberlain and some household officials, received all the petitions that were presented to him; listened attentively to all the complaints, all the requests of the applicants; consoled one, encouraged others.... The vulgarity of the manners, the familiarity of speech, the insistence of some,
4275-440: A novel: it reinforces, in truth, the ideas that the viewers bring, being zero in terms of increased knowledge... In this way, it leads the viewer more to debauchery than to critical reflection on the history of Brazil". Diverse visual representations of John range from an overweight, oversized, sloppy appearance to a dignified and elegant character. As for historians' portrayals, researcher Ismênia de Lima Martins writes, "If there
4446-407: A place in the popular imagination as Dom John VI. That image is very varied, "but rarely for good reason. ... It is not strange that the tribulations of his marriage and family life and the references to his personality and personal customs, would invite easy caricature and circulation of an unflattering, if not comic, tradition." the King is popularly shown as indolent, silly and clumsy, subjugated by
4617-509: A powerful political figure, influencing a controversial choice of the Queen's ministers that favored John, but not without encountering strong opposition from important fidalgos who had ambitions for those posts. In the year after the deaths of his brother and the Archbishop, John became ill to the extent that his own survival was uncertain. He recovered, but in 1791, he again fell ill "bleeding from
4788-602: A revolt that proclaimed Brazilian independence on 1822-09-07; as part of this action, he assumed the title of emperor of Brazil. Tradition says that before journeying to Portugal, John had anticipated future events and had said to his son: "Pedro, Brazil will soon be separated from Portugal: if so, put the crown on your head before some adventurer grabs it." According to the memoirs of the Count of Palmela, Brazilian independence had come about through common accord between King John and Prince Pedro. In any event, later correspondence between
4959-532: A role in human metabolism. However, arsenic poisoning occurs in multicellular life if quantities are larger than needed. Arsenic contamination of groundwater is a problem that affects millions of people across the world. The United States' Environmental Protection Agency states that all forms of arsenic are a serious risk to human health. The United States' Agency for Toxic Substances and Disease Registry ranked arsenic number 1 in its 2001 prioritized list of hazardous substances at Superfund sites. Arsenic
5130-511: A shrewish wife, a disgusting glutton who always had baked chicken in his coat pockets to eat them at any time with greasy hands, a version typified by the Brazilian film Carlota Joaquina – Princesa do Brasil (1995), a parody mixed with sharp social criticism. That work had enormous repercussions, but, according to the critical commentary of Ronaldo Vainfas, "it is a story full of errors of all types, misrepresentations, imprecisions, inventions"; for historian Luiz Carlos Villalta, "it constitutes
5301-425: A sovereign nation. Economic restrictions fell and thoughts of the country's interests moved to the front of government policy." But first it was necessary to provide accommodations for the newcomers, a difficult problem to resolve given the cramped proportions of the city of Rio at that time. In particular, there were few homes suitable for the nobility, especially in the case of the royal family, who were installed in
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5472-591: A subsidiary of Pfizer Inc., which produces roxarsone, voluntarily suspended sales of the drug in response to studies showing elevated levels of inorganic arsenic, a carcinogen, in treated chickens. A successor to Alpharma, Zoetis , continued to sell nitarsone until 2015, primarily for use in turkeys. During the 17th, 18th, and 19th centuries, a number of arsenic compounds were used as medicines, including arsphenamine (by Paul Ehrlich ) and arsenic trioxide (by Thomas Fowler ), for treating diseases such as cancer or psoriasis . Arsphenamine, as well as neosalvarsan ,
5643-544: A turbulent period; his reign never saw a lasting peace. Throughout his period of rule, major powers, such as Spain , France. and Great Britain , continually intervened in Portuguese affairs. Forced to flee across the Atlantic Ocean to Brazil when troops of the Emperor Napoleon I invaded Portugal, he found himself faced there with liberal revolts; he was compelled to return to Europe amid new conflicts. His marriage
5814-415: A version of photosynthesis in the absence of oxygen with arsenites as electron donors , producing arsenates (just as ordinary photosynthesis uses water as electron donor, producing molecular oxygen). Researchers conjecture that, over the course of history, these photosynthesizing organisms produced the arsenates that allowed the arsenate-reducing bacteria to thrive. One strain , PHS-1, has been isolated and
5985-432: Is a chemical element with the symbol As and the atomic number 33. It is a metalloid and one of the pnictogens , and therefore shares many properties with its group 15 neighbors phosphorus and antimony . Arsenic is a notoriously toxic heavy metal . It occurs naturally in many minerals , usually in combination with sulfur and metals, but also as a pure elemental crystal . It has various allotropes , but only
6156-458: Is a stub . You can help Misplaced Pages by expanding it . This article about the history of Brazil is a stub . You can help Misplaced Pages by expanding it . This article about the history of Uruguay is a stub . You can help Misplaced Pages by expanding it . John VI of Portugal Dom John VI ( Portuguese : João VI ; 13 May 1767 – 10 March 1826), nicknamed " the Clement ", was King of
6327-401: Is agreement among all authors who relied on the testimony of those who knew him closely for his kindness and affability, all the rest is controversy. While some pointed to his countenance of a statesman, others considered him a coward and completely unprepared to govern. In any event, Dom João VI left his indelible mark on Portuguese-Brazilian history, a fact that resonates to the present, through
6498-458: Is classified as a Group-A carcinogen . The three most common arsenic allotropes are grey, yellow, and black arsenic, with grey being the most common. Grey arsenic (α-As, space group R 3 m No. 166) adopts a double-layered structure consisting of many interlocked, ruffled, six-membered rings. Because of weak bonding between the layers, grey arsenic is brittle and has a relatively low Mohs hardness of 3.5. Nearest and next-nearest neighbors form
6669-587: Is estimated that approximately 57 million people in the Bengal basin are drinking groundwater with arsenic concentrations elevated above the World Health Organization 's standard of 10 parts per billion (ppb). However, a study of cancer rates in Taiwan suggested that significant increases in cancer mortality appear only at levels above 150 ppb. The arsenic in the groundwater is of natural origin, and
6840-511: Is genuinely tribasic, with the formula As(OH) 3 . A broad variety of sulfur compounds of arsenic are known. Orpiment ( As 2 S 3 ) and realgar ( As 4 S 4 ) are somewhat abundant and were formerly used as painting pigments. In As 4 S 10 , arsenic has a formal oxidation state of +2 in As 4 S 4 which features As-As bonds so that the total covalency of As is still 3. Both orpiment and realgar, as well as As 4 S 3 , have selenium analogs;
7011-589: Is in alloying with lead. Lead components in car batteries are strengthened by the presence of a very small percentage of arsenic. Dezincification of brass (a copper-zinc alloy) is greatly reduced by the addition of arsenic. "Phosphorus Deoxidized Arsenical Copper" with an arsenic content of 0.3% has an increased corrosion stability in certain environments. Gallium arsenide is an important semiconductor material, used in integrated circuits . Circuits made from GaAs are much faster (but also much more expensive) than those made from silicon . Unlike silicon, GaAs has
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7182-636: Is inhalation of atmospheric gases and dusts. During the Victorian era , arsenic was widely used in home decor, especially wallpapers. In Europe, an analysis based on 20,000 soil samples across all 28 countries show that 98% of sampled soils have concentrations less than 20 mg kg-1. In addition, the As hotspots are related to frequent fertilization and close distance to mining activities. Extensive arsenic contamination of groundwater has led to widespread arsenic poisoning in Bangladesh and neighboring countries. It
7353-427: Is little danger in eating fish because this arsenic compound is nearly non-toxic. Naturally occurring sources of human exposure include volcanic ash , weathering of minerals and ores, and mineralized groundwater. Arsenic is also found in food, water, soil, and air. Arsenic is absorbed by all plants, but is more concentrated in leafy vegetables, rice, apple and grape juice, and seafood. An additional route of exposure
7524-433: Is recovered primarily from copper refinement dust. On roasting arsenopyrite in air, arsenic sublimes as arsenic(III) oxide leaving iron oxides, while roasting without air results in the production of gray arsenic. Further purification from sulfur and other chalcogens is achieved by sublimation in vacuum, in a hydrogen atmosphere, or by distillation from molten lead-arsenic mixture. The word arsenic has its origin in
7695-550: Is related to the gammaproteobacterium Ectothiorhodospira shaposhnikovii . The mechanism is unknown, but an encoded Arr enzyme may function in reverse to its known homologues . In 2011, it was postulated that the Halomonadaceae strain GFAJ-1 could be grown in the absence of phosphorus if that element were substituted with arsenic, exploiting the fact that the arsenate and phosphate anions are similar structurally. The study
7866-461: Is released from the sediment into the groundwater, caused by the anoxic conditions of the subsurface. This groundwater was used after local and western NGOs and the Bangladeshi government undertook a massive shallow tube well drinking-water program in the late twentieth century. This program was designed to prevent drinking of bacteria-contaminated surface waters, but failed to test for arsenic in
8037-474: Is resistant to all-trans retinoic acid . A 2008 paper reports success in locating tumors using arsenic-74 (a positron emitter). This isotope produces clearer PET scan images than the previous radioactive agent, iodine -124, because the body tends to transport iodine to the thyroid gland producing signal noise. Nanoparticles of arsenic have shown ability to kill cancer cells with lesser cytotoxicity than other arsenic formulations. The main use of arsenic
8208-490: Is stable only below −50 °C, at which temperature it decomposes to the trichloride, releasing chlorine gas. ) Arsenic is used as the group 5 element in the III-V semiconductors gallium arsenide , indium arsenide , and aluminium arsenide . The valence electron count of GaAs is the same as a pair of Si atoms, but the band structure is completely different which results in distinct bulk properties. Other arsenic alloys include
8379-490: Is the 22nd most abundant element in seawater and ranks 41st in abundance in the universe. Minerals with the formula MAsS and MAs 2 (M = Fe , Ni , Co ) are the dominant commercial sources of arsenic, together with realgar (an arsenic sulfide mineral) and native (elemental) arsenic. An illustrative mineral is arsenopyrite ( Fe As S ), which is structurally related to iron pyrite . Many minor As-containing minerals are known. Arsenic also occurs in various organic forms in
8550-485: Is therefore called a monoisotopic element . As of 2024, at least 32 radioisotopes have also been synthesized, ranging in atomic mass from 64 to 95. The most stable of these is As with a half-life of 80.30 days. All other isotopes have half-lives of under one day, with the exception of As ( t 1/2 =65.30 hours), As ( t 1/2 =26.0 hours), As ( t 1/2 =17.77 days), As ( t 1/2 =26.26 hours), and As ( t 1/2 =38.83 hours). Isotopes that are lighter than
8721-496: Is typically pyramidal owing to the influence of the lone pair of electrons . One of the simplest arsenic compounds is the trihydride, the highly toxic, flammable, pyrophoric arsine (AsH 3 ). This compound is generally regarded as stable, since at room temperature it decomposes only slowly. At temperatures of 250–300 °C decomposition to arsenic and hydrogen is rapid. Several factors, such as humidity , presence of light and certain catalysts (namely aluminium) facilitate
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#17328527431688892-455: Is used to detect precise levels of intracellular arsenic and other arsenic bases involved in epigenetic modification of DNA. Studies investigating arsenic as an epigenetic factor can be used to develop precise biomarkers of exposure and susceptibility. The Chinese brake fern ( Pteris vittata ) hyperaccumulates arsenic from the soil into its leaves and has a proposed use in phytoremediation . Inorganic arsenic and its compounds, upon entering
9063-696: The Renaissance era . During the Bronze Age , arsenic was melted with copper to make arsenical bronze . Jabir ibn Hayyan described the isolation of arsenic before 815 AD. Albertus Magnus (Albert the Great, 1193–1280) later isolated the element from a compound in 1250, by heating soap together with arsenic trisulfide . In 1649, Johann Schröder published two ways of preparing arsenic. Crystals of elemental (native) arsenic are found in nature, although rarely. Cadet's fuming liquid (impure cacodyl ), often claimed as
9234-640: The Royal Pantheon of the House of Braganza , in the Monastery of São Vicente de Fora . In the 1990s, a team of investigators exhumed the Chinese ceramic pot that contained his bowels. Fragments of his heart were rehydrated and submitted to an analysis that detected enough arsenic to kill two people, confirming longstanding suspicions of assassination by poison. As a youth, John was a retiring figure, heavily influenced by
9405-504: The Río de la Plata region (now Argentina and Uruguay ) to try to secure a monarchy of her own, perhaps as a regent of Spain, perhaps as queen of a new monarchy created from Spanish colonies in South America, perhaps by deposing her husband. This made any meaningful marriage to John impossible, despite his show of patience, and only the force of convention had them appear together in public. While
9576-531: The Syriac word ܙܪܢܝܟܐ zarnika , from Arabic al-zarnīḵ الزرنيخ 'the orpiment ', based on Persian zar ("gold") from the word زرنيخ zarnikh , meaning "yellow" (literally "gold-colored") and hence "(yellow) orpiment". It was adopted into Greek (using folk etymology ) as arsenikon ( ἀρσενικόν ) – a neuter form of the Greek adjective arsenikos ( ἀρσενικός ), meaning "male", "virile". Latin -speakers adopted
9747-710: The United Kingdom of Portugal, Brazil and the Algarves from 1816 to 1825. Although the United Kingdom of Portugal ceased to exist de facto beginning in 1822, he remained its monarch de jure between 1822 and 1825. After the recognition of the independence of Brazil under the Treaty of Rio de Janeiro of 1825, he continued as King of Portugal until his death in 1826. Under the same treaty, he also became titular Emperor of Brazil for life, while his son, Emperor Pedro I ,
9918-625: The Vietnam War , the United States used Agent Blue , a mixture of sodium cacodylate and its acid form, as one of the rainbow herbicides to deprive North Vietnamese soldiers of foliage cover and rice. Some species of bacteria obtain their energy in the absence of oxygen by oxidizing various fuels while reducing arsenate to arsenite. Under oxidative environmental conditions some bacteria use arsenite as fuel, which they oxidize to arsenate. The enzymes involved are known as arsenate reductases (Arr). In 2008, bacteria were discovered that employ
10089-597: The War of the Oranges ; a defeated Portugal signed the Treaty of Badajoz and the subsequent Treaty of Madrid , under which it ceded territory to Spain, in particular Olivenza , and made concessions to the French over certain colonial territories. With conflicting interests among all the countries involved, the war was marked by ambiguous movements and secret agreements. Portugal, as the weakest player, could not avoid continued struggle. At
10260-409: The equatorial zone under a scorching heat that caused moods to turn quite sour. The flotilla also faced two storms and was eventually dispersed near Madeira . In the middle of the voyage, Prince John changed his plans and decided to head for Salvador, Bahia , probably for political reasons. He wanted to please the inhabitants of the colony's first capital, which had given many signs of discontent with
10431-490: The food chain , are progressively metabolized through a process of methylation . For example, the mold Scopulariopsis brevicaulis produces trimethylarsine if inorganic arsenic is present. The organic compound arsenobetaine is found in some marine foods such as fish and algae, and also in mushrooms in larger concentrations. The average person's intake is about 10–50 μg/day. Values about 1000 μg are not unusual following consumption of fish or mushrooms, but there
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#173285274316810602-660: The honorific orders of Portugal . When Napoleon was defeated in 1815, the European powers held the Congress of Vienna to reorganize the political map of the continent. Portugal participated in these negotiations, but given British overtures contrary to the interests of the House of Braganza , Portugal's ambassador to the Congress, the Count of Palmela , counseled the regent to remain in Brazil, as did
10773-457: The nonmetals . Though stable in dry air, arsenic forms a golden-bronze tarnish upon exposure to humidity which eventually becomes a black surface layer. When heated in air, arsenic oxidizes to arsenic trioxide ; the fumes from this reaction have an odor resembling garlic. This odor can be detected on striking arsenide minerals such as arsenopyrite with a hammer. It burns in oxygen to form arsenic trioxide and arsenic pentoxide , which have
10944-536: The 20th century. A 2006 study of the remains of the Australian racehorse Phar Lap determined that its 1932 death was caused by a massive overdose of arsenic. Sydney veterinarian Percy Sykes stated, "In those days, arsenic was quite a common tonic, usually given in the form of a solution ( Fowler's Solution ) ... It was so common that I'd reckon 90 per cent of the horses had arsenic in their system." The toxicity of arsenic to insects, bacteria, and fungi led to its use as
11115-428: The 8th, the whole court finally disembarked to encounter a city adorned to receive them with nine days of uninterrupted celebrations. A well-known chronicler of the era, Father Perereca, eyewitness to the arrival, while lamenting the news of the invasion of metropolitan Portugal, also intuited the significance of the arrival of the court on Brazilian soil: If so great were the motives of sorrow and distress, no less were
11286-736: The Academia dos Guardas-Marinhas, the Academia Militar, the National Library of Brazil , the Royal Museum (now National Museum of Brazil ), the Teatro Real de São João (now Teatro João Caetano ), as well as recruiting internationally famous soloists and patronizing other musicians of the Royal Chapel, including Father José Maurício , the leading Brazilian composer of his time, supporting also
11457-521: The As ion as the formation of such an anion would be highly endothermic and even the group 1 arsenides have properties of intermetallic compounds. Like germanium , selenium , and bromine , which like arsenic succeed the 3d transition series , arsenic is much less stable in the +5 oxidation state than its vertical neighbors phosphorus and antimony , and hence arsenic pentoxide and arsenic acid are potent oxidizers . Compounds of arsenic resemble, in some respects, those of phosphorus , which occupies
11628-476: The British government, which in practice flooded the small internal market with useless trinkets, disadvantaged exports, and the creation of new national industries. Laurentino Gomes writes that John granted more hereditary titles in his first eight years in Brazil than had been granted in the previous three hundred years of the Portuguese monarchy, not even counting more than five thousand insignia and commendations of
11799-466: The British guaranteed him help in case of an eventual flight of the royal family. The accord greatly favored the British and preserved their influence over the country, as British merchants continued to make vast profits in trade with the Portuguese intercontinental empire. It fell to Portugal to choose between an alliance with France or with Britain, and the hesitancy to decide firmly placed Portugal at risk of war with both. In October 1807, news arrived that
11970-575: The French conquest of northeastern Spain. This created a delicate diplomatic problem, as Portugal could not make peace with France without damaging an alliance with Britain that involved several overseas interests. The Portuguese thus sought a neutrality that proved fragile and tense. After the defeat, Spain abandoned its alliance with Portugal and allied with France under the Peace of Basel . With Britain too powerful for France to attack directly, France set its sights on Portugal. In 1799, John officially assumed
12141-406: The French general Jean-Andoche Junot described John as "a weak man, suspicious of everyone and everything, jealous of his authority but incapable of making it respected. He is dominated by the fathers [that is, priests] and can act only under the duress of fear", and several Brazilian historians such as João Pandiá Calógeras , Tobias Monteiro and Luiz Norton draw him in comparably dark colors. Among
12312-550: The General Postal Administration, as well as bringing Brazilians into administrative and staff positions, which helped diminish tensions between the natives and the Portuguese. He also encouraged agricultural production, especially cotton, rice and sugar cane , opened roads and encouraged the development of inland waterways, stimulating the movement of people, goods and products between regions. According to Pedreira and Costa, few Portuguese monarchs have as large
12483-494: The Greek term as arsenicum , which in French ultimately became arsenic , whence the English word "arsenic". Arsenic sulfides (orpiment, realgar ) and oxides have been known and used since ancient times. Zosimos ( c. 300 AD ) describes roasting sandarach (realgar) to obtain cloud of arsenic ( arsenic trioxide ), which he then reduces to gray arsenic. As the symptoms of arsenic poisoning are not very specific,
12654-482: The II-V semiconductor cadmium arsenide . A large variety of organoarsenic compounds are known. Several were developed as chemical warfare agents during World War I, including vesicants such as lewisite and vomiting agents such as adamsite . Cacodylic acid , which is of historic and practical interest, arises from the methylation of arsenic trioxide, a reaction that has no analogy in phosphorus chemistry. Cacodyl
12825-518: The Island of Madeira, the Azores and reached the captaincy of Grão-Pará and Bahia in Brazil. It led even to an uprising by the military garrison of Rio de Janeiro itself. On 30 January 1821, the Cortes met in Lisbon and decreed the formation of a Council of Regency to exercise power in the name of King John. It freed many political prisoners and demanded the King's immediate return. On 20 April, John convoked
12996-511: The King's younger son, Infante Miguel, instigated by his mother Carlota Joaquina, led another revolt known as the Vilafrancada on 27 May, with the intent of restoring absolutism. John changed the game by supporting Miguel to avoid his own deposition (which was desired by Carlota Joaquina's party). He appeared in public on his birthday alongside his son, who wore a uniform of the National Guard,
13167-460: The Paço de São Cristóvão and the viceregal palace in the city, staying also at times at Paquetá Island , Governador Island , at Praia Grande (the beach at Niterói ), and at the House of Santa Cruz. He went hunting and happily slept in a tent or under a tree. He liked the countryside, despite the swarms of mosquitoes and other pests and the scorching heat of the tropics that were detested by the majority of
13338-674: The Portuguese and Brazilian monarchy was now something of a protectorate, was the most direct beneficiary. Salvador spent a month in commemorations of the presence of the court and tried to seduce the court into making it the new seat of the Kingdom. The residents offered to construct a luxurious palace as a home for the royal family, but John declined and continued his voyage, having already announced to various nations his intention to make his capital at Rio de Janeiro. His ship entered Guanabara Bay on 7 March, where he met his daughters and other members of his entourage whose ships had arrived earlier. On
13509-439: The Portuguese and other foreigners. In the course of his few years living in Brazil, John ordered the creation of a series of institutions, projects and services that brought the country immense economic, administrative, juridical, scientific, cultural, artistic and other benefits, although not all went successfully, and some were downright dysfunctional or unnecessary, as Hipólito José da Costa mordantly observed. Among these, he
13680-433: The Portuguese, such as Oliveira Martins and Raul Brandão , he was invariably portrayed as a burlesque figure until the conservative resurgence of 1926, when he began to find defenders, such as Fortunato de Almeida, Alfredo Pimenta and Valentim Alexandre. It is also certain that many were disaffected with him, that he raised taxes and aggravated the debt, multiplied titles and hereditary privilege, that he could not allay
13851-468: The Queen gained many sympathizers, her plots uniformly failed. Despite that, she managed to influence her husband to involve himself more directly in Spanish colonial politics. These efforts led to the capture of Montevideo in 1817 and the annexation of Cisplatina Province in 1821. During the same period, problems arose in finding a wife for John's son Dom Pedro, Prince Royal of Portugal (the new title for
14022-506: The Queen. Portugal's biggest problems at this time, however, related to the independence of Brazil, which had been the country's largest source of wealth. The loss of Brazil had a great negative impact on the Portuguese economy. An expedition to reconquer the former colony was even considered, but the idea was soon abandoned. Difficult negotiations and consultations undertaken in Europe in Rio de Janeiro with British diplomatic mediation resulted in
14193-419: The U.S. doctrine of Manifest Destiny . He asserted his authority without violence, more in a persuasive and affable manner; his conduct of international affairs, although sometimes unsuccessful and somewhat given to imperialist ambitions, in many other ways was far-seeing and harmonious, as indicated by the many actions described above that improved the living conditions of the Brazilian colony. Nonetheless,
14364-464: The U.S. minister Sumter, who "greatly preferred to address himself directly to the monarch, always willing to do justice, than to confer with his ministers.... deeming him in this matter much more advanced than his courtiers". Diplomatic documents also confirm the breadth of his political vision, aiming to give Brazil an importance in the Americas comparable to the United States, adopting a discourse similar
14535-430: The United States by 2013 in all agricultural activities except cotton farming. The biogeochemistry of arsenic is complex and includes various adsorption and desorption processes. The toxicity of arsenic is connected to its solubility and is affected by pH. Arsenite ( AsO 3− 3 ) is more soluble than arsenate ( AsO 3− 4 ) and is more toxic; however, at a lower pH, arsenate becomes more mobile and toxic. It
14706-953: The War Ministry, the Foreign Ministry, and the Ministry of Marine and Overseas; the Councils of State and of Finance, the Supreme Military Council, the Military Archive, the Bureaus of Justice and of Conscience and Orders, the Casa de Suplicação (Supreme Court), the Intendency General of Police, the first Bank of Brazil the Royal Board of Commerce, Agriculture, Factories and Navigation, and
14877-600: The account of José Acúrsio das Neves, the departure brought forth deep emotion on the part of the Prince Regent: He wanted to speak and could not; he wanted to move and, convulsed, did not succeed in taking a step; he walked over an abyss, and envisioned a future dark and as uncertain as the ocean to which he was about to deliver himself. Country, capital, kingdom, vassals, he was about to leave all of these suddenly, with little hope of setting eyes on them again, and all were thorns that pierced his heart. To explain himself to
15048-533: The age of 27. Before his accession to the Portuguese throne, John bore the titles Duke of Braganza , Duke of Beja, and Prince of Brazil . From 1799, he served as prince regent due to the mental illness of his mother. In 1816, he succeeded his mother as monarch of the Portuguese Empire , with no real change in his authority, since he already possessed absolute powers as regent. One of the last representatives of absolute monarchy in Europe, John VI lived during
15219-438: The analogous As 2 Te 3 is known as the mineral kalgoorlieite , and the anion As 2 Te is known as a ligand in cobalt complexes. All trihalides of arsenic(III) are well known except the astatide, which is unknown. Arsenic pentafluoride (AsF 5 ) is the only important pentahalide, reflecting the lower stability of the +5 oxidation state; even so, it is a very strong fluorinating and oxidizing agent. (The pentachloride
15390-423: The basis of a new government. The prince, however, already leaning toward liberal ideas, refused. The crisis had gone too far and there was no turning back. John named Pedro regent for Brazil in his name and left for Lisbon on 25 April 1821 after a stay of thirteen years in Brazil, a country he would always miss. The ships bringing John and his court arrived in Lisbon on 3 July. His return was orchestrated in such
15561-427: The beginning of May 1785, and on 9 June, the couple received a nuptial benediction at the palace chapel. However, the marriage seemed to be an uncomfortable one. An assiduous correspondence between John and Mariana at that time reveals that the absence of his sister weighed upon him and, comparing her to his young wife, he wrote, "She is very smart and has a lot of judgment, whereas you have rather little, and I like her
15732-486: The bride's youth (she was only 10 years old at the time), the marriage required a papal dispensation. After being confirmed, the marriage capitulation was signed in the throne room of the Spanish court with great pomp and with the participation of both kingdoms. It was followed immediately by a proxy marriage. The marriage was consummated five years later. Carlota Joaquina was received at the Ducal Palace of Vila Viçosa at
15903-526: The causes of comfort and pleasure: a new order of things was going to begin this part of the southern hemisphere. The design of the Empire of Brazil could already be considered in place, and eagerly wished the powerful hand of our lord the Prince Regent to cast the first stone of future greatness, prosperity and power of the new empire. John helped change Brazil from an ordinary colony into a booming society. This
16074-496: The clergy, and lived surrounded by priests and attending daily Mass in the church. Nonetheless, Oliveira Lima affirms that rather than being an expression of personal piety, this merely reflected Portuguese culture at that time, and that the King "...understood that the Church, with its body of traditions and its moral discipline, could only be useful for a good government in his manner, paternal and exclusive, of populations whose dominion
16245-591: The coming of the Missão Artística Francesa , which resulted in the establishment of the Escola Real de Ciências, Artes e Ofícios , predecessor of the present-day Escola Nacional de Belas Artes of the Federal University of Rio de Janeiro , of fundamental importance the renewal of teaching and art production in Brazil. John's policies led to far-reaching economic changes, beginning with the opening of
16416-500: The council of ministers and showed generosity to the others who had rebelled. Still, this did not dissuade the Queen from further conspiracies. The police discovered another rebellion planned for 26 October, on the basis of which John placed his wife under house arrest in Queluz Palace. At the end of his reign, King John ordered the creation of a free port in Lisbon, but the measure was not implemented. He ordered further inquiry into
16587-504: The court introduced new standards of etiquette, new fashions and new customs, including a new social stratification. Among the customs, John continued in Brazil the ancient Portuguese ceremony of the beija-mão , which he esteemed greatly and which fascinated the Brazilians and became part of their folklore. He received his subjects daily, except for Sundays and holidays. The long lines waiting to pay their respects and receive favors were
16758-560: The court would return to its old metropolis once the European political situation returned to normal. However, these advances became the basis for Brazil's future autonomy. This is not to say that all was amenities and progress. A series of political crises began shortly after the Prince Regent's arrival with the invasion of Cayenne in French Guiana in 1809 in retaliation for the French invasion of Portugal, serious economic problems, and an unfavorable trade agreement negotiated in 1810 with
16929-403: The creation of a huge number of institutions and public services and boosted the economy, culture and other areas of national life. All these measures were taken principally because of the practical needs of administering a large empire in a territory previously lacking of these resources, because the predominant idea continued to be that Brazil would remain a colony, given that it was expected that
17100-400: The daily life of Rio; rents doubled, taxes rose, and food was in short supply, requisitioned by the imported nobility. This soon dispelled popular enthusiasm over the prince regent's arrival. The very shape of the city began to change, with the construction of innumerable new residences, villas and other buildings, and various improvements to services and infrastructure. Likewise, the presence of
17271-519: The death of his former friend the Marquis of Loulé , but final judgment was never rendered. On 5 June he granted amnesty to those involved in the Porto uprising, except for nine officers who were exiled. On the same day, the old constitution of the Kingdom came back into force, and the Cortes reconvened to prepare a new text. The change of constitution faced several obstacles, mainly from Spain and from supporters of
17442-493: The death of his mother on 20 March 1816, John assumed the throne as King Dom John VI. However, he was not immediately consecrated as king; he was acclaimed only on 6 February 1818, with grand festivities. Meanwhile, several political matters came to the fore. John's wife, the ambitious Carlota Joaquina, had begun to conspire against Portuguese interests while still in Europe. Shortly after her arrival in Brazil, she established understandings with both Spaniards and with nationalists of
17613-593: The environment. In 2014, China was the top producer of white arsenic with almost 70% world share, followed by Morocco, Russia, and Belgium, according to the British Geological Survey and the United States Geological Survey . Most arsenic refinement operations in the US and Europe have closed over environmental concerns. Arsenic is found in the smelter dust from copper, gold, and lead smelters, and
17784-590: The face of resistance. Despite the efforts of Viceroy Marcos de Noronha e Brito and of Joaquim José de Azevedo, the regent was still poorly accommodated. Merchant Elias Antônio Lopes offered his country house, the Quinta da Boa Vista , a sumptuous villa in excellent location that immediately met with the prince's satisfaction. Renovations and expansion transformed this into the Paço de São Cristóvão ("Palace of Saint Christopher"). Carlota Joaquina, for her part, preferred to settle on
17955-513: The father. The case was hushed up, and the young woman was sent to Spain to bear the child. She gave birth to a daughter, whose name is unknown. The mother lived the rest of her life in nunneries and John supported her financially. In the precarious and spare environment of Rio, the King's personal habits were simple. In contrast to his relative isolation in Portugal, he became more personally dynamic and interested in nature. He moved frequently between
18126-586: The fields). The accidental use of arsenic in the adulteration of foodstuffs led to the Bradford sweet poisoning in 1858, which resulted in 21 deaths. From the late-18th century wallpaper production began to use dyes made from arsenic, which was thought to increase the pigment's brightness. One account of the illness and 1821 death of Napoleon I implicates arsenic poisoning involving wallpaper. Two arsenic pigments have been widely used since their discovery – Paris Green in 1814 and Scheele's Green in 1775. After
18297-496: The final recognition of the independence on 29 August 1825. At the same time, John freed all the Brazilians who were prisoners and authorized trade between both nations. It was agreed that Pedro would govern Brazil as Emperor, while John kept for himself the honor of Titular Emperor of Brazil; from this time, he signed official documents as "His Majesty the Emperor and King Dom John VI" ("Sua Majestade o Imperador e Rei Dom João VI"). Brazil
18468-399: The first synthetic organometallic compound , was synthesized in 1760 by Louis Claude Cadet de Gassicourt through the reaction of potassium acetate with arsenic trioxide . In the Victorian era , women would eat "arsenic" (" white arsenic " or arsenic trioxide) mixed with vinegar and chalk to improve the complexion of their faces, making their skin paler (to show they did not work in
18639-783: The foundation of various societies and academies for scientific, literary and artistic studies, such as the Junta Vacínica (administering the smallpox vaccine ), the Royal Bahiense Society of Men of Letters, the Academic Institute of Sciences and Fine Arts, the Fluminense Academy of Sciences and Arts, the Escola Anatômica, Cirúrgica e Médica do Rio de Janeiro, the Royal Academy of Artillery, Fortification and Design,
18810-489: The gates of Lisbon only on 30 November 1807. By this time, the Prince Regent, accompanied by the entire royal family and a large following of nobles, state functionaries and servants, had already embarked, leaving the government under a regency with the recommendation that the army not engage in hostilities with the invader. The hasty departure during a rainstorm caused havoc in Lisbon as an astonished population could not believe that their prince had abandoned them. According to
18981-570: The grey form, which has a metallic appearance, is important to industry. The primary use of arsenic is in alloys of lead (for example, in car batteries and ammunition ). Arsenic is a common n-type dopant in semiconductor electronic devices. It is also a component of the III–V compound semiconductor gallium arsenide . Arsenic and its compounds, especially the trioxide, are used in the production of pesticides , treated wood products, herbicides , and insecticides . These applications are declining with
19152-589: The groundwater. Many other countries and districts in Southeast Asia, such as Vietnam and Cambodia , have geological environments that produce groundwater with a high arsenic content. Arsenicosis was reported in Nakhon Si Thammarat , Thailand, in 1987, and the Chao Phraya River probably contains high levels of naturally occurring dissolved arsenic without being a public health problem because much of
19323-525: The heir apparent). Europe at the time considered Brazil distant, backward and unsafe, so it was not a simple task to find suitable candidates. After a year of seeking, the ambassador Pedro José Joaquim Vito de Meneses Coutinho, 6th Marquis of Marialva , finally secured an alliance with one of Europe's most powerful royal houses, the Austrian Habsburgs , after seducing the Austrian court with numerous lies,
19494-456: The increasing recognition of the toxicity of arsenic and its compounds. Arsenic has been known since ancient times to be poisonous to humans. However, a few species of bacteria are able to use arsenic compounds as respiratory metabolites . Trace quantities of arsenic have been proposed to be an essential dietary element in rats, hamsters, goats, and chickens. Research has not been conducted to determine whether small amounts of arsenic may play
19665-424: The latter being close to the maximum capacity of the squadron of fifteen ships, including their crews. Still, the ships were overcrowded. According to Pedreira e Costa, taking into account all of the variables, the most likely numbers fall between four and seven thousand passengers plus the crews. Many families were separated, and even high officials failed to secure a place on the ships and were left behind. The voyage
19836-562: The latter, he decreed the creation of a public lecture series on economics and a school of surgery, but his most decisive action at this moment was the Decree of Opening the Ports to Friendly Nations ( Decreto de Abertura dos Portos às Nações Amigas ), a measure of vast political and economic importance and the first of many that went to improve conditions in the colony. Britain, however, whose economy depended in great part on maritime commerce, and for whom
20007-543: The loss of its old status. The ships carrying his wife and daughters held to the original destination of Rio de Janeiro . On 22 January 1808, the Prince Regent's ship and the two others arrived in Baía de Todos os Santos , Brazil. The streets of Salvador were deserted, because the governor, the Count of Ponte, preferred to await the prince's orders before permitting the people to receive him. Finding this attitude odd, John ordered that all could come as they wished. However, to allow
20178-577: The mentors of many of John's most important undertakings, but according to John Luccock: "The prince regent has been various times accused of apathy; to me, he seemed to have greater sensitivity and strength of character than was generally attributed to him by both friends and opponents. He was placed in new circumstances by which he was tested, bowing before them with patience; if incited, he acted with vigor and promptness". He also praised King John's character, reaffirming his kindness and attention. Oliveira Lima, with his classic Dom João VI no Brasil (1908),
20349-407: The mouth and intestines", according to notes left by the chaplain of the Marquis of Marialva , who added that John's spirit was always depressed. This created a tense climate and uncertainty about his future reign. Meanwhile, the Queen showed increasing signs of mental instability. As a result, of her illness, the queen was deemed unfit to rule and John essentially took control of the country. John
20520-468: The night of 9 March, he took a turn for the worse and died at approximately 5 a.m. on 10 March. The infanta immediately assumed the internal government of Portugal, and Pedro was recognized as the legitimate heir as King Dom Pedro IV. Doctors could not definitively determine a cause of death, but it was suspected that John had been poisoned. His body was embalmed and buried in the mausoleum of the Kings of Portugal,
20691-487: The nobility to compose themselves after such an arduous journey, the landing was postponed until the next day, when they were received joyfully amidst a procession, the ringing of bells and a celebration of a Te Deum at the Cathedral of Salvador . In the following days, John received all who wished to give homage, granting the ceremony of the beija-mão (the kissing of the monarch's hand) and conceding various mercies. Among
20862-554: The people, John ordered that posters be put up along the streets stating that his departure was unavoidable despite all efforts made to assure the integrity and peace of the Kingdom. The posters recommended that everyone remain calm, orderly and not resist the invaders, so that blood not be shed in vain. Because of the rush to depart, the Prince Regent was in a ship together with his mother and his sons Dom Pedro, Prince of Beira (later Emperor Dom Pedro I of Brazil and King Dom Pedro IV of Portugal), and Miguel (later King Dom Miguel I ). This
21033-424: The ports and the abolition of the Portuguese commercial monopolies, with the United Kingdom being the great beneficiary. On the one hand, traders based in Brazil had to face strong foreign competition; on the other, it encouraged the creation of new manufacturing and other economic activities that were previously banned, poor or nonexistent in Brazil. At the same time, he created such high-level administrative bodies as
21204-461: The powerful Prince Talleyrand , in order to strengthen the ties between metropolis and colony, including the suggestion to elevate Brazil to the condition of a kingdom united to Portugal. The British representative to the Congress also ended up supporting the idea, which resulted in the effective foundation of the United Kingdom of Portugal, Brazil and the Algarves on 16 December 1815, a juridical institution rapidly recognized by other nations. With
21375-431: The pragmatic one was enough for him. In the Royal Chapel he more took pleasure with the senses than he prayed with the spirit: andantes took the place of meditations." John had a great appreciation of sacred music and was a great reader of works about art, but he detested physical activity. He appeared to have suffered periodic crises of depression . An aversion to changes in his routine extended to his clothing: he wore
21546-408: The presence of mercury vapors. It is glassy and brittle. Black arsenic is also a poor electrical conductor. Arsenic sublimes upon heating at atmospheric pressure , converting directly to a gaseous form without an intervening liquid state at 887 K (614 °C). The triple point is at 3.63 MPa and 1,090 K (820 °C). Arsenic occurs in nature as one stable isotope , As, and
21717-565: The progressive ideas of the Enlightenment and appeared to have been inclined toward the anti-clerical policies of Sebastião José de Carvalho e Melo, 1st Marquis of Pombal . John, in contrast, was well known for his religiosity and his attachment to absolutism. The crisis of succession was aggravated with the death in November 1788 of the Queen's confessor, Inácio de São Caetano , the titular archbishop of Thessalonica . The Archbishop had been
21888-456: The prolixity of others, none of this bored him. He seemed to forget that he was their master, and remember only that he was their father." Oliveira Lim wrote that he "never confused the faces or the pleas, and the applicants marveled at how well he know their lives, their families, even small incidents that had occurred in the past and which they could not believe had risen to the notice of the King." Throughout his stay in Brazil, John formalized
22059-926: The public uses bottled water . In Pakistan, more than 60 million people are exposed to arsenic polluted drinking water indicated by a 2017 report in Science . Podgorski's team investigated more than 1200 samples and more than 66% exceeded the WHO minimum contamination level. Since the 1980s, residents of the Ba Men region of Inner Mongolia, China have been chronically exposed to arsenic through drinking water from contaminated wells. A 2009 research study observed an elevated presence of skin lesions among residents with well water arsenic concentrations between 5 and 10 μg/L, suggesting that arsenic induced toxicity may occur at relatively low concentrations with chronic exposure. Overall, 20 of China's 34 provinces have high arsenic concentrations in
22230-512: The question of corruption, noting that although there were enormous costs and clear abuses, at that time there was no clear separation between the public treasury and the monarch's private accounts, and in the logic of the Old Regime "the King is the owner of the state... of which the distribution of spoils forms part: the King is the dispenser of justice and spoils". Before dying on Saint Helena , John's most powerful enemy, Napoleon, said of him: "He
22401-444: The rate of decomposition. It oxidises readily in air to form arsenic trioxide and water, and analogous reactions take place with sulfur and selenium instead of oxygen . Arsenic forms colorless, odorless, crystalline oxides As 2 O 3 (" white arsenic ") and As 2 O 5 which are hygroscopic and readily soluble in water to form acidic solutions. Arsenic(V) acid is a weak acid and its salts, known as arsenates , are
22572-405: The recently approved constitution, but the absolute regime was restored, the Queen's rights re-established, and the King acclaimed for a second time on 5 June. John repressed demonstrations against this restoration, deported some of the liberals and arrested others, ordered the restoration of judiciary and institutions more in line with the new political orientation and created a commission to draft
22743-454: The reins of government as prince regent in the name of his mother; that same year, Napoleon Bonaparte staged his coup d'état of 18 Brumaire in France and coerced Spain into issuing an ultimatum to force the Portuguese to break with Great Britain and submit the country to the interests of Napoleon. With John's refusal, neutrality became unviable. Spain and France invaded in 1801, setting off
22914-494: The revolutionaries executed their former king Louis XVI , precipitating an international response. On 15 July, Portugal signed a treaty with Spain, and on 26 September allied itself with Great Britain. Both treaties pledged mutual aid against revolutionary France and brought six thousand Portuguese soldiers into the War of the Pyrenees (1793–1795), a campaign that began with an advance to Roussillon in France and ended in defeat with
23085-406: The same group (column) of the periodic table . The most common oxidation states for arsenic are: −3 in the arsenides , which are alloy-like intermetallic compounds, +3 in the arsenites , and +5 in the arsenates and most organoarsenic compounds. Arsenic also bonds readily to itself as seen in the square As 3− 4 ions in the mineral skutterudite . In the +3 oxidation state , arsenic
23256-419: The same coat until it tore, forcing his chamberlains to sew it on his body while he slept in it. He suffered from panic attacks when he heard thunder, staying in his rooms with the windows shut and receiving no one. John's marriage was never a happy one. Rumors circulated that at the age of 25 he fell in love with Eugênia José de Menezes, his wife's chaperone. She became pregnant, and John was suspected of being
23427-443: The same structure as the more well-known phosphorus compounds, and in fluorine to give arsenic pentafluoride . Arsenic makes arsenic acid with concentrated nitric acid , arsenous acid with dilute nitric acid, and arsenic trioxide with concentrated sulfuric acid ; however, it does not react with water, alkalis, or non-oxidising acids. Arsenic reacts with metals to form arsenides , though these are not ionic compounds containing
23598-487: The same time, John had to face an enemy at home. His wife, Princess Carlota Joaquina, loyal to Spanish interests, initiated an intrigue with the objective of deposing her husband and taking power herself. After this attempt failed in 1805, the Princess was exiled from court; she resided at Queluz Palace , while John took up residency at Mafra Palace . It was events like this that led to the Portuguese people questioning if John
23769-460: The situation in Portugal was by no means tranquil. With the King absent and the country devastated by the Peninsular War and the consequent mass hunger and enormous exodus of emigrants, Portugal became a de facto British protectorate upon the final expulsion of the French. It was administered by William Carr Beresford , who took a high hand in his dealings with the Portuguese government. From
23940-476: The stable As tend to decay by β decay , and those that are heavier tend to decay by β decay , with some exceptions. At least 10 nuclear isomers have been described, ranging in atomic mass from 66 to 84. The most stable of arsenic's isomers is As with a half-life of 111 seconds. Arsenic has a similar electronegativity and ionization energies to its lighter pnictogen congener phosphorus and therefore readily forms covalent molecules with most of
24111-566: The substance was frequently used for murder until the advent in the 1830s of the Marsh test , a sensitive chemical test for its presence. (Another less sensitive but more general test is the Reinsch test .) Owing to its use by the ruling class to murder one another and its potency and discreetness, arsenic has been called the "poison of kings" and the "king of poisons". Arsenic became known as "the inheritance powder" due to its use in killing family members in
24282-420: The thirteen years in which the Portuguese court lived in Rio de Janeiro". Scholars such as Oliveira Lima, Maria Odila da Silva Dias, Roderick Barman and the aforementioned Laurentino believe that had John not come to the Americas and installed a strong central government, the large territory of Brazil, with important regional differences, would probably have fragmented into several distinct nations, as occurred with
24453-679: The time John ascended the throne, the Portuguese pressed for his return, initiated liberal rebellions, and formed secret societies with the objective of bringing into session the Portuguese Cortes , which had not met since 1698. Similar liberal agitation occurred in Brazil. In 1817, the Pernambucan Revolt broke out in Recife , a republican movement that established a provisional government in Pernambuco and spread into other Brazilian states; it
24624-456: The toxicity of arsenic became widely known, these chemicals were used less often as pigments and more often as insecticides. In the 1860s, an arsenic byproduct of dye production, London Purple, was widely used. This was a solid mixture of arsenic trioxide, aniline, lime, and ferrous oxide, insoluble in water and very toxic by inhalation or ingestion But it was later replaced with Paris Green , another arsenic-based dye. With better understanding of
24795-451: The toxicology mechanism, two other compounds were used starting in the 1890s. Arsenite of lime and arsenate of lead were used widely as insecticides until the discovery of DDT in 1942. In small doses, soluble arsenic compounds act as stimulants , and were once popular as medicine by people in the mid-18th to 19th centuries; this use was especially prevalent for sport animals such as race horses or work dogs and continued into
24966-569: The two shows the prince's concern not to disturb his father. However, Portugal did not officially recognize Brazilian independence at this time. The liberal constitution to which the King had sworn loyalty was in effect only for a few months. Not everyone in Portugal supported liberalism, and an absolutist movement arose. On 23 February 1823 in Trás-os-Montes , Francisco Silveira, Count of Amarante , proclaimed an absolute monarchy; this did not immediately have an effect, and new agitations followed.
25137-428: The vast array of internal dissensions or eliminate entrenched administrative corruption, and that he left Brazil on the brink of bankruptcy when he emptied the treasury to return to Portugal. Whatever the King's character may have been, the importance of his reign for a remarkable spurt of development for Brazil and, indeed, for the very unity of that nation is incontestable. Gilberto Freyre affirms that "Dom John VI
25308-489: The vast neighboring Spanish colony. This opinion was shared by the British admiral Sir Sidney Smith , who served as commander of the squadron that escorted the Portuguese royal court as they fled to Brazil. Recent biographies try to separate fact from legend and counter the folklore of ridicule that had formed around King John and which lacks documentary basis. Lúcia Bastos warns that even today we need to be careful to place certain matters in their historical context, such as
25479-629: The viceregal palace, known today as the Paço Imperial (Imperial Palace). Though large, it was comfortless and nothing like Portuguese palaces. As large as it was, it was not enough to accommodate everyone, so neighboring buildings were also requisitioned, such as the Carmelite Convent, the town hall, and even the jail. To meet the needs of other nobles, and to install new government offices, innumerable small residences were hastily expropriated, their proprietors arbitrarily ejected, at times violently in
25650-492: Was John's situation at the time), government would be exercised by the guardians of those children or, if guardians had not been formally named, by the wife of the regent. In John's case, that would have been a Spanish infanta. Fear, suspicion and intrigue engulfed the entire institutional framework of the nation. At the same time, the French Revolution perplexed and horrified the reigning houses of Europe. In January 1793,
25821-489: Was also used in various agricultural insecticides and poisons. For example, lead hydrogen arsenate was a common insecticide on fruit trees , but contact with the compound sometimes resulted in brain damage among those working the sprayers. In the second half of the 20th century, monosodium methyl arsenate (MSMA) and disodium methyl arsenate (DSMA) – less toxic organic forms of arsenic – replaced lead arsenate in agriculture. These organic arsenicals were in turn phased out in
25992-432: Was an imprudent decision given the dangers of a transatlantic voyage in that era, since it placed at risk the succession of the crown in case of shipwreck. Carlota Joaquina and her daughters were on two other ships. The number of people who embarked with John remains a matter of controversy; in the 19th century there was talk of up to 30 thousand emigrants; more recent estimates vary between five hundred and fifteen thousand,
26163-498: Was both de facto and de jure the monarch of the newly independent country. John VI was born in Lisbon in 1767 during the reign of his maternal grandfather, King Dom Joseph I of Portugal . He was the second son of the Princess of Brazil and Infante Peter of Portugal, who later became Queen Dona Maria I and King Dom Peter III . John became heir to the throne when his older brother, Prince José , died of smallpox in 1788 at
26334-491: Was capable of commanding the nation and whether he was as incapable of ruling as his mother was. John played a desperate game with France for time. For as long as he could, he pretended an apparent submission to France, to the point of suggesting to King George III of the United Kingdom the declaration of a fictitious state of war between their countries, but he did not obey the dictates of Napoleon's Continental System (a blockade against Great Britain). A new secret treaty with
26505-541: Was done, in large part, to the establishment of a new government in the capital, Rio de Janeiro. With a government, the essential apparatus of a sovereign state became inevitable: the senior civil, religious, and military officials, aristocrats and liberal professionals, skilled artisans, and public servants. For many scholars, the transfer of the court to Rio began the establishment of the modern Brazilian state and constituted Brazil's first step toward true independence. While Brazil at this time remained formally and juridically
26676-451: Was found that addition of sulfur, phosphorus, and iron oxides to high-arsenite soils greatly reduces arsenic phytotoxicity. Arsenic is used as a feed additive in poultry and swine production , in particular it was used in the U.S. until 2015 to increase weight gain, improve feed efficiency , and prevent disease. An example is roxarsone , which had been used as a broiler starter by about 70% of U.S. broiler growers. In 2011, Alpharma,
26847-490: Was indicated for syphilis , but has been superseded by modern antibiotics . However, arsenicals such as melarsoprol are still used for the treatment of trypanosomiasis , since although these drugs have the disadvantage of severe toxicity, the disease is almost uniformly fatal if untreated. In 2000 the US Food and Drug Administration approved arsenic trioxide for the treatment of patients with acute promyelocytic leukemia that
27018-441: Was inherited with the scepter. Because of this, he was repeatedly the guest of monks and patron to composers of sacred music , but none of these Epicurean or artistic demonstrations compromised his free thought or denatured his skeptical tolerance. ... He made more use of the refectory of the monastery than of its chapel, because [the latter] was about observance and in [the former] one thought of gastronomy, and in terms of observance
27189-471: Was no less conflictual, as his wife Carlota Joaquina of Spain repeatedly conspired against her husband in favor of personal interests or those of her native Spain. John lost Brazil when his son Pedro declared independence, and his other son Miguel (later Miguel I of Portugal ) led a rebellion that sought to depose him. According to recent scholarly research, his death may well have been caused by arsenic poisoning. Notwithstanding these tribulations John left
27360-428: Was not a tranquil one. Several ships were in precarious condition, and overcrowding created humiliating conditions for the nobility, the majority of whom had to sleep huddled in the open in the poops . Hygienic conditions were bad, including an epidemic of head lice. Many had failed to bring changes of clothing. Several people fell ill. Supplies were scarce, causing rationing. The flotilla spent ten days nearly becalmed in
27531-468: Was not only Maria's husband, but also her paternal uncle. John was ten years old when his grandfather died and his mother ascended to the throne. His childhood and youth were lived quietly in the shadow of Queen Maria I's older son and heir apparent, José, Prince of Brazil and Duke of Braganza . Folklore has Infante John as a rather uncultured youth, but according to Jorge Pedreira e Costa, he received as rigorous an education as his brother José did. Still,
27702-418: Was one of the major figures responsible for the beginning of John's large-scale rehabilitation. He researched innumerable documents of the era without finding unfavorable descriptions of the King by Brazilians or by ambassadors and other diplomats accredited to the court. On the contrary, he found many accounts that painted him in favorable colors, such as the testimonies left by the British consul Henderson and
27873-399: Was one of the personalities who had the greatest influence over the formation of the nation.... he was an ideal mediator.... between tradition – which he incarnated – and innovation – which he welcomed and promoted – during that decisive period for the Brazilian future". As Laurentino Gomes puts it, "no other period of Brazilian history testifies to such profound decisive and rapid changes as
28044-585: Was put down severely. Back in Portugal, the Liberal Revolution of 1820 broke out in Porto on 24 August 1820. A governing junta was set up, with repercussions in Lisbon. It met as the General Extraordinary and Constituent Cortes ( Cortes Gerais Extraordinárias e Constituintes ), formed a government and convened elections for deputies without bothering to consult King John. The movement gained support from
28215-478: Was reluctant to take the reins of power, rejecting the idea of a formal regency . This opened the way for elements of the nobility to form a de facto government via a Council. Rumors circulated that John exhibited symptoms of the same insanity, and that he might be prevented from ruling. According to longstanding laws that guided the institution of regency, were the regent to die or become incapable for any reason, and having children of less than fourteen years (which
28386-707: Was required to pay certain funds that it had borrowed from Portugal. Nothing in the treaty spoke of the succession of the two crowns, but Pedro, still acting as the Prince Royal of Portugal and Algarve, implicitly remained heir to the Portuguese throne. On 4 March 1826, John returned from the Hieronymites Monastery where he had lunched and retired to Bemposta Palace feeling poorly. He was racked for several days by symptoms including vomiting and convulsions. He appeared to be getting better, but by way of prudence designated his daughter Infanta Isabel Maria as regent. On
28557-818: Was responsible for establishing the Imprensa Régia (the country's first publishing house), the Rio de Janeiro Botanical Garden the Arsenal de Marinha , the Fábrica de Pólvora (gunpowder factory), Rio's fire department, Brazil's merchant marine, and the charity hospital known as the Casa dos Expostos. He also established various educational programs in Rio, Pernambuco, Bahia and other places, teaching such subjects as dogmatic and moral theology, integral calculus , mechanics, hydrodynamics , chemistry , arithmetic , geometry, French , English , botany and agriculture, among others. He instigated
28728-553: Was taken into custody at the Bemposta Palace , while several of Miguel's political enemies were also imprisoned elsewhere. The infante's intent was to force his father to abdicate. Alerted to the situation, the diplomatic corps managed to enter Bemposta Palace. Those who held the King could not resist such authorities and restored a measure of freedom to the King. On 9 May, on the advice of friendly ambassadors, John pretended to travel to Caxias but, in fact, went and sought refuge with
28899-579: Was the first organometallic compound known (even though arsenic is not a true metal) and was named from the Greek κακωδία "stink" for its offensive, garlic-like odor; it is very toxic. Arsenic is the 53rd most abundant element in the Earth's crust , comprising about 1.5 parts per million (0.00015%). Typical background concentrations of arsenic do not exceed 3 ng/m in the atmosphere; 100 mg/kg in soil; 400 μg/kg in vegetation; 10 μg/L in freshwater and 1.5 μg/L in seawater. Arsenic
29070-603: Was the only one who deceived me." José Joaquim Carneiro de Campos , the Marquis of Caravelas, praised John in the Brazilian Senate on the occasion of the King's death, saying, "All of us who are here have many reasons to praise the memory of King John VI, we all ought to be grateful, for the benefits he gave us: he raised Brazil to a kingdom, provided well for all of us, treated us always with great affection, and all Brazilians are obligated to him." Arsenic Arsenic
29241-1017: Was widely criticised and subsequently refuted by independent researcher groups. Arsenic may be an essential trace mineral in birds, involved in the synthesis of methionine metabolites, with feeding recommendations being between 0.012 and 0.050 mg/kg. Some evidence indicates that arsenic is an essential trace mineral in mammals. However, the biological function is not known. Arsenic has been linked to epigenetic changes , heritable changes in gene expression that occur without changes in DNA sequence . These include DNA methylation, histone modification, and RNA interference. Toxic levels of arsenic cause significant DNA hypermethylation of tumor suppressor genes p16 and p53 , thus increasing risk of carcinogenesis . These epigenetic events have been studied in vitro using human kidney cells and in vivo using rat liver cells and peripheral blood leukocytes in humans. Inductively coupled plasma mass spectrometry (ICP-MS)
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