The Mennonite World Conference ( MWC ) is an international Mennonite Anabaptist Christian denomination . Its headquarters are in Kitchener, Ontario , Canada.
124-673: The first Mennonite World Conference was held in Basel in 1925. Its main purpose was to celebrate the 400th anniversary of Anabaptism. An assembly is convened approximately every six or seven years. Christian Neff (1863–1946), a Mennonite minister in Germany , is often called the "father" of the Mennonite World Conference. Neff, through the Conference of Mennonites in South Germany, issued
248-650: A castrum (fortified camp) was built on the site of the Celtic oppidum . In AD 83, the area was incorporated into the Roman province of Germania Superior . The Roman Senator Munatius Plancus is known as the traditional founder of Basel since the Renaissance. Roman control over the area deteriorated in the 3rd century, and Basel became an outpost of the Provincia Maxima Sequanorum formed by Diocletian . Basilia
372-499: A variety of laws and regulations that govern the patenting , efficacy testing, safety evaluation , and marketing of these drugs. The global pharmaceuticals market produced treatments worth a total of $ 1,228.45 billion in 2020. The sector showed a compound annual growth rate (CAGR) of 1.8% in 2021, including the effects of the COVID-19 pandemic . In historical terms, a pharmaceutical industry as an intellectual concept arose within
496-492: A 20% drop in those for which antibiotics were not effective. The report concluded that "it appears that the use of antibiotics, early diagnosis, and other factors have limited the epidemic spread and thus the number of these diseases which have occurred". The study further examined mortality rates for eight common diseases for which antibiotics offered effective therapy (syphilis, tuberculosis, dysentery, scarlet fever, whooping cough, meningococcal infections, and pneumonia), and found
620-517: A 56% decline over the same period. Notable among these was a 75% decline in deaths due to tuberculosis. During the years 1940–1955, the rate of decline in the U.S. death rate accelerated from 2% per year to 8% per year, then returned to the historical rate of 2% per year. The dramatic decline in the immediate post-war years has been attributed to the rapid development of new treatments and vaccines for infectious disease that occurred during these years. Vaccine development continued to accelerate, with
744-411: A Japanese biochemist working for the pharmaceutical company Sankyo, identified mevastatin (ML-236B), a molecule produced by the fungus Penicillium citrinum , as an inhibitor of HMG-CoA reductase, a critical enzyme used by the body to produce cholesterol. Animal trials showed very good inhibitory effect as in clinical trials , however a long-term study in dogs found toxic effects at higher doses and as
868-414: A compound is identified as a potential drug in order to establish its suitability as a medication. Objectives of drug development are to determine appropriate formulation and dosing , as well as to establish safety . Research in these areas generally includes a combination of in vitro studies, in vivo studies, and clinical trials . The cost of late stage development has meant it is usually done by
992-465: A drug could be sold, and explicitly prohibited false therapeutic claims. The aftermath of World War II saw an explosion in the discovery of new classes of antibacterial drugs including the cephalosporins (developed by Eli Lilly based on the seminal work of Giuseppe Brotzu and Edward Abraham ), streptomycin (discovered during a Merck-funded research program in Selman Waksman's laboratory ),
1116-524: A handful of wealthy families collectively referred to as the "Daig" played a pivotal role in city affairs as they gradually established themselves as a de facto city aristocracy . The first edition of Christianae religionis institutio ( Institutes of the Christian Religion – John Calvin 's great exposition of Calvinist doctrine) was published at Basel in March 1536. In 1544, Johann von Brugge,
1240-540: A heart attack were reduced by 42%. In 1995, Zocor and Mevacor both made Merck over US$ 1 billion. Endo was awarded the 2006 Japan Prize , and the Lasker-DeBakey Clinical Medical Research Award in 2008. For his "pioneering research into a new class of molecules" for "lowering cholesterol," Since several decades, biologics have been rising in importance in comparison with small molecules treatments. The biotech subsector, animal health and
1364-501: A highly toxic solvent that is now widely used as antifreeze. Under the laws extant at that time, prosecution of the manufacturer was possible only under the technicality that the product had been called an "elixir", which literally implied a solution in ethanol. In response to this episode, the U.S. Congress passed the Federal Food, Drug, and Cosmetic Act of 1938 , which for the first time required pre-market demonstration of safety before
SECTION 10
#17328515682161488-515: A name Basilia attested in northern France as a development of basilica , the term for a public or church building (as in Bazeilles ), but all of these names reference early church buildings of the 4th or 5th century and cannot be adduced for the 3rd-century attestation of Basilia . By popular etymology, or simple assonance, the basilisk becomes closely associated with the city, used as heraldic supporter from 1448, represented on coins minted by
1612-469: A number of companies developed products based on adrenal extracts containing varying purities of the active substance. In 1897, John Abel of Johns Hopkins University identified the active principle as epinephrine , which he isolated in an impure state as the sulfate salt. Industrial chemist Jōkichi Takamine later developed a method for obtaining epinephrine in a pure state, and licensed the technology to Parke-Davis . Parke-Davis marketed epinephrine under
1736-499: A protocol to discontinue their use. A series of experiments performed from the late 1800s to the early 1900s revealed that diabetes is caused by the absence of a substance normally produced by the pancreas. In 1869, Oskar Minkowski and Joseph von Mering found that diabetes could be induced in dogs by surgical removal of the pancreas. In 1921, Canadian professor Frederick Banting and his student Charles Best repeated this study and found that injections of pancreatic extract reversed
1860-463: A push for revisions of the FD&;C Act emerged from Congressional hearings led by Senator Estes Kefauver of Tennessee in 1959. The hearings covered a wide range of policy issues, including advertising abuses, questionable efficacy of drugs, and the need for greater regulation of the industry. While momentum for new legislation temporarily flagged under extended debate, a new tragedy emerged that underscored
1984-504: A reduction in initial public offerings being floated. A 2022 article articulated this notion succinctly by saying "In the business of drug development, deals can be just as important as scientific breakthroughs", typically referred to as pharmaceutical M&A (for mergers and acquisitions). It highlighted that some of the most impactful of the remedies of the early 21st Century were only made possible through M&A activities, specifically noting Keytruda and Humira . Drug discovery
2108-464: A relic, possibly attributed to Saint Germanus of Granfelden . This staff (known as Baselstab ) became a symbol representing the Basel diocese, depicted in bishops' seals of the late medieval period. It is represented in a heraldic context in the early 14th century, not yet as a heraldic charge but as a kind of heraldic achievement flanked by the heraldic shields of the bishop. The staff is also represented in
2232-400: A result mevastatin was believed to be too toxic for human use. Mevastatin was never marketed, because of its adverse effects of tumors, muscle deterioration, and sometimes death in laboratory dogs. P. Roy Vagelos , chief scientist and later CEO of Merck & Co , was interested, and made several trips to Japan starting in 1975. By 1978, Merck had isolated lovastatin (mevinolin, MK803) from
2356-508: A rich Dutch Protestant refugee, was given citizenship and lived respectably until his death in 1556, then buried with honors. His body was exhumed and burnt at the stake in 1559 after it was discovered that he was the Anabaptist David Joris . In 1543, De humani corporis fabrica , the first book on human anatomy, was published and printed in Basel by Andreas Vesalius (1514–1564). There are indications Joachim Meyer , author of
2480-431: A series of such compounds, and was found to exhibit partially selective toxicity. Arsphenamine proved to be the first effective treatment for syphilis , a disease untl then had been incurable and led inexorably to severe skin ulceration, neurological damage, and death. Ehrlich's approach of systematically varying the chemical structure of synthetic compounds and measuring the effects of these changes on biological activity
2604-557: A sleep aid beginning in 1904. Systematic investigations of the effect of structural changes on potency and duration of action led to the discovery of phenobarbital at Bayer in 1911 and the discovery of its potent anti-epileptic activity in 1912. Phenobarbital was among the most widely used drugs for the treatment of epilepsy through the 1970s, and as of 2014, remains on the World Health Organizations list of essential medications. The 1950s and 1960s saw increased awareness of
SECTION 20
#17328515682162728-489: A small fraction are eventually approved in most nations by government-appointed medical institutions or boards, who have to approve new drugs before they can be marketed in those countries. In 2010 18 NMEs (New Molecular Entities) were approved and three biologics by the FDA, or 21 in total, which is down from 26 in 2009 and 24 in 2008. On the other hand, there were only 18 approvals in total in 2007 and 22 back in 2006. Since 2001,
2852-558: A third of the global pharmaceutical market, with $ 340 billion in annual sales followed by the EU and Japan. Emerging markets such as China, Russia, South Korea and Mexico outpaced that market, growing a huge 81 percent. The top ten best-selling drugs of 2013 totaled $ 75.6 billion in sales, with the anti-inflammatory drug Humira being the best-selling drug worldwide at $ 10.7 billion in sales. The second and third best selling were Enbrel and Remicade, respectively. The top three best-selling drugs in
2976-522: Is May during which time Basel receives an average of 98 mm (3.9 in) of rain. The month with the most days of precipitation is also May, with an average of 11.7 days. The driest month of the year is February with an average of 45 mm (1.8 in) of precipitation over 8.4 days. The city of Basel functions as the capital of the Swiss half-canton of Basel-Stadt . The canton Basel-Stadt consists of three municipalities: Riehen , Bettingen , and
3100-578: Is a city in northwestern Switzerland on the River Rhine (at the transition from the High to the Upper Rhine ). Basel is Switzerland's third-most-populous city (after Zurich and Geneva ), with 177,595 inhabitants within the city municipality limits. The official language of Basel is Swiss Standard German and the main spoken language is the local Basel German dialect. Basel is commonly considered to be
3224-451: Is a very large study of efficacy in the intended patient population. Following the successful completion of phase III testing, a New Drug Application is submitted to the FDA. The FDA reviews the data and if the product is seen as having a positive benefit-risk assessment, approval to market the product in the US is granted. A fourth phase of post-approval surveillance is also often required due to
3348-716: Is first named by the Ammianus Marcellinus in his Res Gestae as part of the Roman military fortifications along the Rhine in the late 4th century. The Germanic confederation of the Alemanni attempted to cross the Rhine several times in the 4th century, but were repelled; one such event was the Battle of Solicinium (368). However, in the great invasion of AD 406, the Alemanni appear to have crossed
3472-446: Is forested. Of the rest of the land, 20.67 km (7.98 sq mi) or 86.4% is settled (buildings or roads), 1.45 km (0.56 sq mi) or 6.1% is either rivers or lakes. Of the built up area, industrial buildings made up 10.2% of the total area while housing and buildings made up 40.7% and transportation infrastructure made up 24.0%. Power and water infrastructure as well as other special developed areas made up 2.7% of
3596-708: Is located in Northwestern Switzerland and is commonly considered to be the capital of that region. It is close to the point where the Swiss, French and German borders meet, and Basel also has suburbs in France and Germany. As of 2016 , the Swiss Basel agglomeration was the third-largest in Switzerland, with a population of 541,000 in 74 municipalities in Switzerland (municipal count as of 2018). The metropolitan area , called
3720-450: Is not associated with cancer in people. Other notable new vaccines of the period include those for measles (1962, John Franklin Enders of Children's Medical Center Boston, later refined by Maurice Hilleman at Merck), Rubella (1969, Hilleman, Merck) and mumps (1967, Hilleman, Merck) The United States incidences of rubella, congenital rubella syndrome, measles, and mumps all fell by >95% in
3844-646: Is the Mennonite Church USA Archives . According to a census published by the association in 2022, it would have 107 member denominations in 59 countries, and 1,47 million baptized members in 10,300 churches. The Conference has an Anabaptist confession of faith . The Global Mission Fellowship (GMF) has 71 mission member organizations. The Global Anabaptist Service Network (GASN) supports humanitarian aid projects. Basel Basel ( / ˈ b ɑː z əl / BAH -zəl ; German: [ˈbaːzl̩] ), also known as Basle ,
Mennonite World Conference - Misplaced Pages Continue
3968-430: Is the core guide for pharmacists and clinicians. In many non-US western countries, a 'fourth hurdle' of cost effectiveness analysis has developed before new technologies can be provided. This focuses on the 'efficacy price tag' (in terms of, for example, the cost per QALY ) of the technologies in question. In England and Wales NICE decides whether and in what circumstances drugs and technologies will be made available by
4092-498: Is the most important risk factor for cardiovascular morbidity and mortality , in industrialized countries . Prior to 1940 approximately 23% of all deaths among persons over age 50 were attributed to hypertension. Severe cases of hypertension were treated by surgery. Early developments in the field of treating hypertension included quaternary ammonium ion sympathetic nervous system blocking agents, but these compounds were never widely used due to their severe side effects, because
4216-595: Is the process by which potential drugs are discovered or designed. In the past, most drugs have been discovered either by isolating the active ingredient from traditional remedies or by serendipitous discovery. Modern biotechnology often focuses on understanding the metabolic pathways related to a disease state or pathogen , and manipulating these pathways using molecular biology or biochemistry . A great deal of early-stage drug discovery has traditionally been carried out by universities and research institutions. Drug development refers to activities undertaken after
4340-415: Is the value of the publicly traded companies. Small Molecules modality had 58.2% of the valuation share down from 84.6% in 2003. Biologics was up at 30.5% from 14.5%. The valuation share of Chinese Pharma grew from 2003 to 2021 from 1% to 12% overtaking Switzerland who is now ranked number 3 with 7.7%. The United States had still by far the most valued pharmaceutical industry with 40% of global valuation. 2023
4464-433: The Basel massacre . The Basel earthquake of 1356 destroyed much of the city along with a number of castles in the vicinity. A riot on 26 February 1376, known as Böse Fasnacht , led to the killing of a number of men of Leopold III, Duke of Austria . This was seen as a serious breach of the peace , and the city council blamed "foreign ruffians" for this and executed twelve alleged perpetrators. Leopold nevertheless had
4588-701: The French Revolutionary Wars . In more recent times, the World Zionist Organization held its first congress in Basel from 29 August through 31 August 1897. Because of the Balkan Wars , the (Socialist) Second International held an extraordinary congress at Basel in 1912. In 1989, the Basel Convention was opened for signature with the aim of preventing the export of hazardous waste from wealthy to developing nations for disposal. Basel
4712-508: The Nobel Prize in Medicine for this discovery. Nonetheless, the dramatic decrease in deaths from infectious diseases that occurred prior to World War II was primarily the result of improved public health measures such as clean water and less crowded housing, and the impact of anti-infective drugs and vaccines was significant mainly after World War II. In 1928, Alexander Fleming discovered
4836-468: The Trinational Eurodistrict of Basel (TEB), consists of 62 suburban communes including municipalities in neighboring countries, and counted 829,000 inhabitants in 2007. Basel has an area, as of 2009 , of 23.91 square kilometers (9.23 sq mi). Of this area, 0.95 km (0.37 sq mi) or 4.0% is used for agricultural purposes, while 0.88 km (0.34 sq mi) or 3.7%
4960-521: The Zoo Basel , opened its doors in the south of the city towards Binningen . In 1897 the first World Zionist Congress was held in Basel. Altogether the World Zionist Congress was held in Basel ten times, more than in any other city in the world. On 16 November 1938, the psychedelic drug LSD was first synthesized by Swiss chemist Albert Hofmann at Sandoz Laboratories in Basel. In 1967,
5084-577: The birth control movement and the efforts of activists Margaret Sanger , Mary Dennett , and Emma Goldman . Based on fundamental research performed by Gregory Pincus and synthetic methods for progesterone developed by Carl Djerassi at Syntex and by Frank Colton at G.D. Searle & Co. , the first oral contraceptive, Enovid , was developed by G.D. Searle & Co. and approved by the FDA in 1960. The original formulation incorporated vastly excessive doses of hormones, and caused severe side effects. Nonetheless, by 1962, 1.2 million American women were on
Mennonite World Conference - Misplaced Pages Continue
5208-474: The curing or preventing of disease , as well as alleviating symptoms of illness or injury . Pharmaceutical companies may deal in " generic " medications and medical devices without the involvement of intellectual property , in " brand " materials is specifically tied to a given company's history, or in both within different contexts. The industry's various subdivisions include distinct areas, such as manufacturing biologics , which are all subject to
5332-477: The opportunity cost of investing capital many years before revenues are realized (see Time-value of money ). Because of the very long time needed for discovery, development, and approval of pharmaceuticals, these costs can accumulate to nearly half the total expense. A direct consequence within the pharmaceutical industry value chain is that major pharmaceutical multinationals tend to increasingly outsource risks related to fundamental research, which somewhat reshapes
5456-411: The 11th to 12th century, Basel gradually acquired the characteristics of a medieval city . The main market place is first mentioned in 1091. The first city walls were constructed around 1100 (with improvements made in the mid-13th and in the late 14th century). A city council of nobles and burghers is recorded for 1185, and the first mayor , Heinrich Steinlin of Murbach, for 1253. The first bridge across
5580-534: The 20th century also Hermann Hesse and Karl Jaspers . Basel was the seat of a Prince-Bishopric starting in the 11th century, and joined the Swiss Confederacy in 1501. The city has been a commercial hub and an important cultural centre since the Renaissance , and has emerged as a centre for the chemical and pharmaceutical industries in the 20th century. In 1897, Basel was chosen by Theodor Herzl as
5704-777: The Bishop of Basel was added to the Bench of the Ecclesiastical Princes of the Imperial Diet . In 1500 the construction of the Basel Münster was finished. The city had remained neutral through the Swabian War of 1499 despite being plundered by soldiers on both sides. The Treaty of Basel ended the war and granted the Swiss confederates exemptions from the emperor Maximillian's taxes and jurisdictions, separating Switzerland de facto from
5828-454: The Center for Drug Evaluation and Research has averaged 22.9 approvals a year. This approval comes only after heavy investment in pre-clinical development and clinical trials , as well as a commitment to ongoing safety monitoring . Drugs which fail part-way through this process often incur large costs, while generating no revenue in return. If the cost of these failed drugs is taken into account,
5952-489: The Chinese pharmaceutical sector have also grown substantially. On the organisational side, big international pharma corporations have experienced a substantial decline of their value share. Also, the core generic sector (substitutions for off-patent brands) has been downvalued due to competition. Torreya estimated the pharmaceutical industry to have a market valuation of US$ 7.03 trillion by February 2021 from which US$ 6.1 trillion
6076-626: The Holy Roman Empire. On 9 June 1501, Basel joined the Swiss Confederation as its eleventh canton . It was the only canton that was asked to join, not the other way round. Basel had a strategic location, good relations with Strasbourg and Mulhouse , and control of the corn imports from Alsace, whereas the Swiss lands were becoming overpopulated and had few resources. A provision of the Charter accepting Basel required that in conflicts among
6200-509: The Institute of Experimental Therapy in Berlin. The drug was given the commercial name Salvarsan. Ehrlich, noting both the general toxicity of arsenic and the selective absorption of certain dyes by bacteria, hypothesized that an arsenic-containing dye with similar selective absorption properties could be used to treat bacterial infections. Arsphenamine was prepared as part of a campaign to synthesize
6324-806: The NHS, whilst similar arrangements exist with the Scottish Medicines Consortium in Scotland, and the Pharmaceutical Benefits Advisory Committee in Australia. A product must pass the threshold for cost-effectiveness if it is to be approved. Treatments must represent 'value for money' and a net benefit to society. There are special rules for certain rare diseases ("orphan diseases") in several major drug regulatory territories. For example, diseases involving fewer than 200,000 patients in
SECTION 50
#17328515682166448-546: The Old City, and likely identical with the town of Arialbinnum that was mentioned on the Tabula Peutingeriana ). The unfortified settlement was abandoned in the 1st century BC in favour of an oppidum on the site of Basel Minster , probably in reaction to the Roman invasion of Gaul . In Roman Gaul , Augusta Raurica was established some 20 km (12 mi) from Basel as the regional administrative centre, while
6572-785: The Orange Book site. In the UK, the Medicines and Healthcare products Regulatory Agency approves and evaluates drugs for use. Normally an approval in the UK and other European countries comes later than one in the USA. Then it is the National Institute for Health and Care Excellence (NICE), for England and Wales, who decides if and how the National Health Service (NHS) will allow (in the sense of paying for) their use. The British National Formulary
6696-477: The Rhine a final time, conquering and then settling what is today Alsace and a large part of the Swiss Plateau . The Duchy of Alemannia fell under Frankish rule in the 6th century. The Alemannic and Frankish settlement of Basel gradually grew around the old Roman castle in the 6th and 7th century. It appears that Basel surpassed the ancient regional capital of Augusta Raurica by the 7th century; based on
6820-436: The Rhine was built in 1225 under bishop Heinrich von Thun (at the location of the modern Middle Bridge ), and from this time the settlement of Kleinbasel gradually formed around the bridgehead on the far river bank. The bridge was largely funded by Basel's Jewish community who had settled there a century earlier. For many centuries to come Basel possessed the only permanent bridge over the river "between Lake Constance and
6944-458: The US market. The FDA received authority to regulate advertising of prescription drugs and to establish good manufacturing practices . The law required that all drugs introduced between 1938 and 1962 had to be effective. An FDA - National Academy of Sciences collaborative study showed that nearly 40 percent of these products were not effective. A similarly comprehensive study of over-the-counter products began ten years later. In 1971, Akira Endo ,
7068-735: The United States, or larger populations in certain circumstances are subject to the Orphan Drug Act. Because medical research and development of drugs to treat such diseases is financially disadvantageous, companies that do so are rewarded with tax reductions, fee waivers, and market exclusivity on that drug for a limited time (seven years), regardless of whether the drug is protected by patents. In 2011, global spending on prescription drugs topped $ 954 billion, even as growth slowed somewhat in Europe and North America. The United States accounts for more than
7192-495: The addictive properties and abuse potential of barbiturates and amphetamines and led to increasing restrictions on their use and growing government oversight of prescribers. Today, amphetamine is largely restricted to use in the treatment of attention deficit disorder and phenobarbital in the treatment of epilepsy . In 1958, Leo Sternbach discovered the first benzodiazepine , chlordiazepoxide (Librium). Dozens of other benzodiazepines have been developed and are in use, some of
7316-401: The antibacterial effects of penicillin , but its exploitation for the treatment of human disease awaited the development of methods for its large scale production and purification. These were developed by a U.S. and British government-led consortium of pharmaceutical companies during the world war. There was early progress toward the development of vaccines throughout this period, primarily in
7440-719: The area while parks, green belts and sports fields made up 8.9%. Out of the forested land, all of the forested land area is covered with heavy forests. Of the agricultural land, 2.5% is used for growing crops and 1.3% is pastures. All the water in the municipality is flowing water. Under the Köppen system , Basel features an oceanic climate (Köppen: Cfb ), although with notable continental influences due to its relatively far inland position with cool to cold, overcast winters and warm to hot, humid summers. The city averages 118.2 days of rain or snow annually and on average receives 842 mm (33.1 in) of precipitation . The wettest month
7564-476: The biological effects of these structural changes. By the 1890s, the profound effect of adrenal extracts on many different tissue types had been discovered, setting off a search both for the mechanism of chemical signalling and efforts to exploit these observations for the development of new drugs. The blood pressure raising and vasoconstrictive effects of adrenal extracts were of particular interest to surgeons as hemostatic agents and as treatment for shock, and
SECTION 60
#17328515682167688-478: The bishop and from the Habsburgs and was free to pursue its own policy of territorial expansion, beginning around 1400. The unique representation of a bishops' crozier as the heraldic charge in the coat of arms of Basel first appears in the form of a gilded wooden staff in the 12th century. It is of unknown origin or significance (beyond its obvious status of bishop's crozier), but it is assumed to have represented
7812-553: The bishops's seals of the period. The use of the Baselstab in black as the coat of arms of the city was introduced in 1385. From this time, the Baselstab in red represented the bishop, and the same charge in black represented the city. The blazon of the municipal coat of arms is In Silber ein schwarzer Baselstab (Argent, a staff of Basel sable). In 1400, Basel was able to purchase the towns of Liestal , Homburg and Waldenburg with its surrounding territory. In 1412 (or earlier),
7936-670: The call for the first gathering in 1925, and was president of the following meetings in 1930 and 1936. The MWC prints a quarterly news publication in three languages—Spanish (as Correo ), English ( Courier ), and French ( Courrier .) This project began in 1986. The Mennonite World Conference considers that its mission is to (1) be a global community of faith in the Anabaptist-tradition, (2) facilitate relationships between Anabaptist-related churches worldwide, and (3) relate to other Christian world communions and organizations. The official repository of Mennonite World Conference
8060-422: The city Basel itself. The political structure and agencies of the city and the canton are identical. Pharmaceutical industry The pharmaceutical industry is an industry involved in medicine that discovers, develops, produces, and markets pharmaceutical goods for use as drugs which are then administered to (or self-administered by) patients. These medications are created and put to market for
8184-522: The city placed under imperial ban , and in a treaty of 9 July, Basel was given a heavy fine and was placed under Habsburg control. To free itself from Habsburg hegemony, Basel joined the Swabian League of Cities in 1385, and many knights of the pro-Habsburg faction, along with duke Leopold himself, were killed in the Battle of Sempach the following year. A formal treaty with Habsburg was made in 1393. Basel had gained its de facto independence from both
8308-585: The city was for all practical purposes independent although it continued to nominally pledge fealty to the bishops. The House of Habsburg attempted to gain control over the city. This was not successful, but it caused a political split among the burghers of Basel into a pro-Habsburg faction, known as Sterner , and an anti-Habsburg faction, the Psitticher . The Black Death reached Basel in 1348. The Jews were blamed , and an estimated 50 to 70 Jews were executed by burning on 16 January 1349 in what has become known as
8432-448: The city, and frequently found in ornaments. The Middle French form Basle was adopted into English, but this form has fallen gradually out of use although it continues to be used in some sections of British English including the BBC . Currently, the spelling Basel is most often used, to match the official German spelling. In French Basle was still in use in the 18th century, but
8556-503: The city-canton, making Basel one of the largest cultural centres in relation to its size and population in Europe. The University of Basel , Switzerland's oldest university (founded in 1460), and the city's centuries-long commitment to humanism , have made Basel a safe haven at times of political unrest in other parts of Europe for such notable people as Erasmus of Rotterdam , the Holbein family, Friedrich Nietzsche , Carl Jung , and in
8680-404: The cost of developing a successful new drug ( new chemical entity , or NCE), has been estimated at US$ 1.3 billion (not including marketing expenses ). Professors Light and Lexchin reported in 2012, however, that the rate of approval for new drugs has been a relatively stable average rate of 15 to 25 for decades. Industry-wide research and investment reached a record $ 65.3 billion in 2009. While
8804-590: The cost of research in the U.S. was about $ 34.2 billion between 1995 and 2010, revenues rose faster (revenues rose by $ 200.4 billion in that time). A study by the consulting firm Bain & Company reported that the cost for discovering, developing and launching (which factored in marketing and other business expenses) a new drug (along with the prospective drugs that fail) rose over a five-year period to nearly $ 1.7 billion in 2003. According to Forbes, by 2010 development costs were between $ 4 billion to $ 11 billion per drug. Some of these estimates also take into account
8928-716: The cultural capital of Switzerland and the city is famous for its many museums , including the Kunstmuseum , which is the first collection of art accessible to the public in the world (1661) and the largest museum of art in Switzerland , the Fondation Beyeler (located in Riehen ), the Museum Tinguely and the Museum of Contemporary Art , which is the first public museum of contemporary art in Europe. Forty museums are spread throughout
9052-451: The data supporting the safety of thalidomide was incomplete. The firm continued to pressure Kelsey and the FDA to approve the application until November 1961, when the drug was pulled off the German market because of its association with grave congenital abnormalities. Several thousand newborns in Europe and elsewhere suffered the teratogenic effects of thalidomide. Without approval from the FDA,
9176-409: The development of tricyclic antidepressants in the 1960s. In 1903, Hermann Emil Fischer and Joseph von Mering disclosed their discovery that diethylbarbituric acid, formed from the reaction of diethylmalonic acid, phosphorus oxychloride and urea, induces sleep in dogs. The discovery was patented and licensed to Bayer pharmaceuticals , which marketed the compound under the trade name Veronal as
9300-472: The evidence of a gold tremissis (a small gold coin with the value of a third of a solidus ) with the inscription Basilia fit , Basel seems to have minted its own coins in the 7th century. Basel at this time was part of the Archdiocese of Besançon . A separate bishopric of Basel , replacing the ancient bishopric of Augusta Raurica , was established in the 8th century. Under bishop Haito (r. 806–823),
9424-448: The extent that such laws did exist, enforcement was lax. In the United States, increased regulation of vaccines and other biological drugs was spurred by tetanus outbreaks and deaths caused by the distribution of contaminated smallpox vaccine and diphtheria antitoxin. The Biologics Control Act of 1902 required that federal government grant premarket approval for every biological drug and for the process and facility producing such drugs. This
9548-425: The fact that even the largest clinical trials cannot effectively predict the prevalence of rare side-effects. Postmarketing surveillance ensures that after marketing the safety of a drug is monitored closely. In certain instances, its indication may need to be limited to particular patient groups, and in others the substance is withdrawn from the market completely. The FDA provides information about approved drugs at
9672-670: The firm distributed Kevadon to over 1,000 physicians there under the guise of investigational use. Over 20,000 Americans received thalidomide in this "study," including 624 pregnant patients, and about 17 known newborns suffered the effects of the drug. The thalidomide tragedy resurrected Kefauver's bill to enhance drug regulation that had stalled in Congress, and the Kefauver-Harris Amendment became law on 10 October 1962. Manufacturers henceforth had to prove to FDA that their drugs were effective as well as safe before they could go on
9796-418: The first vaccine against Japanese Encephalitis . Hilleman later moved to Merck , where he played a key role in the development of vaccines against measles , mumps , chickenpox , rubella , hepatitis A , hepatitis B , and meningitis . Prior to the 20th century, drugs were generally produced by small scale manufacturers with little regulatory control over manufacturing or claims of safety and efficacy. To
9920-610: The first cathedral was built on the site of the Roman castle (replaced by a Romanesque structure consecrated in 1019). At the partition of the Carolingian Empire through the Treaty of Verdun in 843, Basel was first given to West Francia and became its German exclave. It passed to East Francia with the Treaty of Meerssen of 870. Basel was destroyed by the Magyars in 917. The rebuilt town became part of Upper Burgundy , and as such
10044-407: The form of academic and government-funded basic research directed toward the identification of the pathogens responsible for common communicable diseases. In 1885, Louis Pasteur and Pierre Paul Émile Roux created the first rabies vaccine . The first diphtheria vaccines were produced in 1914 from a mixture of diphtheria toxin and antitoxin (produced from the serum of an inoculated animal), but
10168-520: The fungus Aspergillus terreus , first marketed in 1987 as Mevacor. In April 1994, the results of a Merck-sponsored study, the Scandinavian Simvastatin Survival Study , were announced. Researchers tested simvastatin , later sold by Merck as Zocor, on 4,444 patients with high cholesterol and heart disease. After five years, the study concluded the patients saw a 35% reduction in their cholesterol, and their chances of dying of
10292-401: The immediate aftermath of widespread vaccination. The first 20 years of licensed measles vaccination in the U.S. prevented an estimated 52 million cases of the disease, 17,400 cases of mental retardation , and 5,200 deaths. Hypertension is a risk factor for atherosclerosis, heart failure , coronary artery disease , stroke , renal disease , and peripheral arterial disease , and
10416-907: The industry ecosystem with biotechnology companies playing an increasingly important role, and overall strategies being redefined accordingly. Some approved drugs, such as those based on re-formulation of an existing active ingredient (also referred to as Line-extensions) are much less expensive to develop. In the United States, new pharmaceutical products must be approved by the Food and Drug Administration (FDA) as being both safe and effective. This process generally involves submission of an Investigational New Drug filing with sufficient pre-clinical data to support proceeding with human trials. Following IND approval, three phases of progressively larger human clinical trials may be conducted. Phase I generally studies toxicity using healthy volunteers. Phase II can include pharmacokinetics and dosing in patients, and Phase III
10540-643: The influential 16th-century martial arts text Kunst des Fechten ("The Art of Fencing"), came from Basel. In 1661 the Amerbaschsches Kabinett , a vast collection of exotic artifacts, coins, medals and books was purchased by Basel. It was to become to the first public museum of art. Its collection became the core of the later Basel Museum of Art . The Bernoulli family, which included important 17th- and 18th-century mathematicians such as Jakob Bernoulli , Johann Bernoulli and Daniel Bernoulli , were from Basel. The 18th-century mathematician Leonhard Euler
10664-436: The isolation of tuberculosis-infected people were an ubiquitous feature of cities in developed countries, with 50% dying within 5 years of admission. A Federal Trade Commission report issued in 1958 attempted to quantify the effect of antibiotic development on American public health. The report found that over the period 1946–1955, there was a 42% drop in the incidence of diseases for which antibiotics were effective and only
10788-462: The larger pharmaceutical companies. The pharmaceuticals and biotechnology industry spends more than 15% of its net sales for Research & Development which is in comparison with other industries by far the highest share. Often, large multinational corporations exhibit vertical integration , participating in a broad range of drug discovery and development, manufacturing and quality control, marketing, sales, and distribution. Smaller organizations, on
10912-413: The law to prosecute manufacturers for making unsupported claims of efficacy were undercut by a Supreme Court ruling restricting the federal government's enforcement powers to cases of incorrect specification of the drug's ingredients. In 1937 over 100 people died after ingesting " Elixir Sulfanilamide " manufactured by S.E. Massengill Company of Tennessee. The product was formulated in diethylene glycol ,
11036-529: The location for the first World Zionist Congress , and altogether the congress was held there ten times over a time span of 50 years, more than in any other location. The city is also home to the world headquarters of the Bank for International Settlements . The name of the city is internationally known through institutions like the Basel Accords , Art Basel and FC Basel . Basel is Switzerland's main centre for
11160-513: The long-term health consequences of high blood pressure had not yet been established, and because they had to be administered by injection. In 1952 researchers at Ciba discovered the first orally available vasodilator, hydralazine . A major shortcoming of hydralazine monotherapy was that it lost its effectiveness over time ( tachyphylaxis ). In the mid-1950s Karl H. Beyer, James M. Sprague, John E. Baer, and Frederick C. Novello of Merck and Co. discovered and developed chlorothiazide , which remains
11284-626: The mid-1800s, and from discoveries resulting from applied research. Intentional drug discovery from plants began with the isolation between 1803 and 1805 of morphine – an analgesic and sleep-inducing agent – from opium by the German apothecary assistant Friedrich Sertürner , who named this compound after the Greek god of dreams, Morpheus . Multinational corporations including Merck , Hoffman-La Roche , Burroughs-Wellcome (now part of Glaxo Smith Kline ), Abbott Laboratories , Eli Lilly and Upjohn (now part of Pfizer ) began as local apothecary shops in
11408-453: The mid-1800s. By the late 1880s, German dye manufacturers had perfected the purification of individual organic compounds from tar and other mineral sources and had also established rudimentary methods in organic chemical synthesis . The development of synthetic chemical methods allowed scientists to systematically vary the structure of chemical substances, and growth in the emerging science of pharmacology expanded their ability to evaluate
11532-522: The middle to late 1800s inside of certain nation-states with developed economies such as Germany , Switzerland , and the United States given that multiple businesses engaging in synthetic organic chemistry , such as a number of firms generating dyestuffs derived from coal tar on a large scale, sought out new applications of their artificial materials in terms of human health . This trend to increased capital investment occurred in tandem with
11656-524: The more popular drugs being diazepam (Valium), alprazolam (Xanax), clonazepam (Klonopin), and lorazepam (Ativan). Due to their far superior safety and therapeutic properties, benzodiazepines have largely replaced the use of barbiturates in medicine, except in certain special cases. When it was later discovered that benzodiazepines, like barbiturates, significantly lose their effectiveness and can have serious side effects when taken long-term, Heather Ashton researched benzodiazepine dependence and developed
11780-448: The most notable achievement of the period being Jonas Salk 's 1954 development of the polio vaccine under the funding of the non-profit National Foundation for Infantile Paralysis . The vaccine process was never patented but was instead given to pharmaceutical companies to manufacture as a low-cost generic . In 1960 Maurice Hilleman of Merck Sharp & Dohme identified the SV40 virus, which
11904-439: The most widely used antihypertensive drug today. This development was associated with a substantial decline in the mortality rate among people with hypertension. The inventors were recognized by a Public Health Lasker Award in 1975 for "the saving of untold thousands of lives and the alleviation of the suffering of millions of victims of hypertension". A 2009 Cochrane review concluded that thiazide antihypertensive drugs reduce
12028-457: The need for more comprehensive regulation and provided the driving force for the passage of new laws. On 12 September 1960, an American licensee, the William S. Merrell Company of Cincinnati, submitted a new drug application for Kevadon ( thalidomide ), a sedative that had been marketed in Europe since 1956. The FDA medical officer in charge of reviewing the compound, Frances Kelsey , believed that
12152-445: The other cantons it was to stay neutral and offer its services for mediation. In 1503, the new bishop Christoph von Utenheim refused to give Basel a new constitution; whereupon, to show its power, the city began to build a new city hall. In 1529, the city became Protestant under Oecolampadius and the bishop's seat was moved to Porrentruy . The bishop's crook was however retained as the city's coat of arms. For centuries to come,
12276-500: The other hand, often focus on a specific aspect such as discovering drug candidates or developing formulations. Often, collaborative agreements between research organizations and large pharmaceutical companies are formed to explore the potential of new drug substances. More recently, multi-nationals are increasingly relying on contract research organizations to manage drug development. Drug discovery and development are very expensive; of all compounds investigated for use in humans only
12400-429: The pH of the extract allowed a relatively pure grade of insulin to be produced. Under pressure from Toronto University and a potential patent challenge by academic scientists who had independently developed a similar purification method, an agreement was reached for non-exclusive production of insulin by multiple companies. Prior to the discovery and widespread availability of insulin therapy the life expectancy of diabetics
12524-459: The pharmaceutical industry, hosting both Novartis and Roche . In 2019 Basel was ranked the tenth most liveable city in the world by Mercer . The name of Basel is first recorded as Basilia in the 3rd century (237/8), at the time referring to the Roman castle . This name is mostly interpreted as deriving from the personal name Basilius , from a toponym villa Basilia (" estate of Basilius") or similar. Another suggestion derives it from
12648-401: The pill, and by 1965 the number had increased to 6.5 million. The availability of a convenient form of temporary contraceptive led to dramatic changes in social mores including expanding the range of lifestyle options available to women, reducing the reliance of women on men for contraceptive practice, encouraging the delay of marriage, and increasing pre-marital co-habitation. In the U.S.,
12772-416: The population of Basel voted in favor of buying three works of art by painter Pablo Picasso which were at risk of being sold and taken out of the local museum of art, due to a financial crisis on the part of the owner's family. Therefore, Basel became the first city in the world where the population of a political community democratically decided to acquire works of art for a public institution. Pablo Picasso
12896-486: The risk of death ( RR 0.89), stroke (RR 0.63), coronary heart disease (RR 0.84), and cardiovascular events (RR 0.70) in people with high blood pressure. In the ensuring years other classes of antihypertensive drug were developed and found wide acceptance in combination therapy, including loop diuretics (Lasix/ furosemide , Hoechst Pharmaceuticals , 1963), beta blockers ( ICI Pharmaceuticals , 1964) ACE inhibitors , and angiotensin receptor blockers . ACE inhibitors reduce
13020-473: The risk of new onset kidney disease [RR 0.71] and death [RR 0.84] in diabetic patients, irrespective of whether they have hypertension. Prior to the Second World war, birth control was prohibited in many countries, and in the United States even the discussion of contraceptive methods sometimes led to prosecution under Comstock laws . The history of the development of oral contraceptives is thus closely tied to
13144-634: The safety of the inoculation was marginal and it was not widely used. The United States recorded 206,000 cases of diphtheria in 1921, resulting in 15,520 deaths. In 1923, parallel efforts by Gaston Ramon at the Pasteur Institute and Alexander Glenny at the Wellcome Research Laboratories (later part of GlaxoSmithKline ) led to the discovery that a safer vaccine could be produced by treating diphtheria toxin with formaldehyde . In 1944, Maurice Hilleman of Squibb Pharmaceuticals developed
13268-612: The scholarly study of pathology as a field advancing significantly, and a variety of businesses set up cooperative relationships with academic laboratories evaluating human injury and disease. Examples of industrial companies with a pharmaceutical focus that have endured to this day after such distant beginnings include Bayer (based out of Germany) and Pfizer (based out of the U.S.). The modern era of pharmaceutical industry began with local apothecaries that expanded for their traditional role of distributing botanical drug s such as morphine and quinine to wholesale manufacture in
13392-420: The sea". The first city guild were the furriers , established in 1226. A total of about fifteen guilds were established in the course of the 13th century, reflecting the increasing economic prosperity of the city. The Crusade of 1267 set out from Basel. Political conflicts between the bishops and the burghers began in the mid-13th century and continued throughout the 14th century. By the late 14th century,
13516-528: The symptoms produced by pancreas removal. Soon, the extract was demonstrated to work in people, but development of insulin therapy as a routine medical procedure was delayed by difficulties in producing the material in sufficient quantity and with reproducible purity. The researchers sought assistance from industrial collaborators at Eli Lilly and Co. based on the company's experience with large scale purification of biological materials. Chemist George B. Walden of Eli Lilly and Company found that careful adjustment of
13640-418: The tetracyclines (discovered at Lederle Laboratories, now a part of Pfizer ), erythromycin (discovered at Eli Lilly and Co.) and their extension to an increasingly wide range of bacterial pathogens. Streptomycin, discovered during a Merck-funded research program in Selman Waksman's laboratory at Rutgers in 1943, became the first effective treatment for tuberculosis. At the time of its discovery, sanitoriums for
13764-494: The trade name Adrenalin . Injected epinephrine proved to be especially efficacious for the acute treatment of asthma attacks, and an inhaled version was sold in the United States until 2011 ( Primatene Mist ). By 1929 epinephrine had been formulated into an inhaler for use in the treatment of nasal congestion. While highly effective, the requirement for injection limited the use of epinephrine and orally active derivatives were sought. A structurally similar compound, ephedrine ,
13888-453: The well-known Gasthof zum Goldenen Sternen was established. Basel became the focal point of western Christendom during the 15th century Council of Basel (1431–1449), including the 1439 election of antipope Felix V . In 1459, Pope Pius II endowed the University of Basel , where such notables as Erasmus of Rotterdam and Paracelsus later taught. At the same time the new craft of printing
14012-505: Was introduced to Basel by apprentices of Johann Gutenberg . In 1461, the land around Farnsburg became a part of Basel. The Schwabe publishing house was founded in 1488 by Johannes Petri and is the oldest publishing house still in business. Johann Froben also operated his printing house in Basel and was notable for publishing works by Erasmus. In 1495, Basel was incorporated into the Upper Rhenish Imperial Circle ;
14136-439: Was a year of layoffs for at least 10,000 people across 129 public biotech firms globally, albeit most small firms; this was a significant increase in reductions versus 2022 was in part due to worsening global financial conditions and a reduction in investment by "generalist investors". Private firms also saw a significant reduction in venture capital investment in 2023, continuing a downward trend started in 2021, which also led to
14260-550: Was born in Basel and studied under Johann Bernoulli. In 1792, the Republic of Rauracia , a revolutionary French client republic , was created. It lasted until 1793. After three years of political agitation and a short civil war in 1833 the disadvantaged countryside seceded from the Canton of Basel, forming the half canton of Basel-Landschaft . Between 1861 and 1878 the city walls were slighted . On 3 July 1874, Switzerland's first zoo,
14384-519: Was developed by Smith, Kline and French as a nasal decongestant under the trade name Benzedrine Inhaler. Amphetamine was eventually developed for the treatment of narcolepsy , post-encephalitic parkinsonism , and mood elevation in depression and other psychiatric indications. It received approval as a New and Nonofficial Remedy from the American Medical Association for these uses in 1937, and remained in common use for depression until
14508-454: Was followed in 1906 by the Pure Food and Drugs Act , which forbade the interstate distribution of adulterated or misbranded foods and drugs. A drug was considered misbranded if it contained alcohol, morphine, opium, cocaine, or any of several other potentially dangerous or addictive drugs, and if its label failed to indicate the quantity or proportion of such drugs. The government's attempts to use
14632-456: Was gradually replaced by the modern French spelling Bâle . In Icelandic, the city is recorded as Buslaraborg in the 12th-century itinerary Leiðarvísir og borgarskipan . There are traces of a settlement at the nearby Rhine knee from the early La Tène period (5th century BC). In the 2nd century BC, there was a village of the Raurici at the site of Basel-Gasfabrik (to the northwest of
14756-476: Was identified by Japanese chemists in the Ma Huang plant and marketed by Eli Lilly as an oral treatment for asthma. Following the work of Henry Dale and George Barger at Burroughs-Wellcome , academic chemist Gordon Alles synthesized amphetamine and tested it in asthma patients in 1929. The drug proved to have only modest anti-asthma effects but produced sensations of exhilaration and palpitations. Amphetamine
14880-626: Was incorporated into the Holy Roman Empire in 1032. From the donation by Rudolph III of Burgundy of the Moutier-Grandval Abbey and all its possessions to Bishop Adalbero II of Metz in 999 until the Reformation , Basel was ruled by Prince-Bishops . In 1019, the construction of the cathedral of Basel (known locally as the Münster ) began under Henry II, Holy Roman Emperor . In
15004-485: Was later shown to cause tumors in many mammalian species. It was later determined that SV40 was present as a contaminant in polio vaccine lots that had been administered to 90% of the children in the United States. The contamination appears to have originated both in the original cell stock and in monkey tissue used for production. In 2004 the National Cancer Institute announced that it had concluded that SV40
15128-448: Was only a few months. The development of drugs for the treatment of infectious diseases was a major focus of early research and development efforts; in 1900, pneumonia, tuberculosis, and diarrhea were the three leading causes of death in the United States and mortality in the first year of life exceeded 10%. In 1911 arsphenamine , the first synthetic anti-infective drug, was developed by Paul Ehrlich and chemist Alfred Bertheim of
15252-535: Was pursued broadly by industrial scientists, including Bayer scientists Josef Klarer, Fritz Mietzsch, and Gerhard Domagk . This work, also based on the testing of compounds available from the German dye industry, led to the development of Prontosil , the first representative of the sulfonamide class of antibiotics . Compared to arsphenamine, the sulfonamides had a broader spectrum of activity and were far less toxic, rendering them useful for infections caused by pathogens such as streptococci . In 1939, Domagk received
15376-607: Was so moved by the gesture that he subsequently gifted the city with an additional three paintings. Basel has often been the site of peace negotiations and other international meetings. The Treaty of Basel (1499) ended the Swabian War . Two years later Basel joined the Swiss Confederation . The Peace of Basel in 1795 between the French Republic and Prussia and Spain ended the First Coalition against France during
#215784