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121-516: Planning for handling returned lunar samples began early in the Apollo program. In 1964, a proposal was made for a small (10 square meters (110 sq ft)) sample receiving laboratory equipped with remote-controlled manipulators operating in a sterile, high-vacuum chamber to prepare samples for distribution to scientists, and this proposal was subsequently expanded to include a clean room with analytical instruments for performing preliminary analyses on

242-448: A particle counter and microorganisms detected and counted through environmental monitoring methods . Polymer tools used in cleanrooms must be carefully determined to be chemically compatible with cleanroom processing fluids as well as ensured to generate a low level of particle generation. When cleaning, only special mops and buckets are used. Cleaning chemicals used tend to involve sticky elements to trap dust, and may need

363-471: A "tunnel" design in which there are spaces called "service chases" that serve as air plenums carrying the air from the bottom of the room to the top so that it can be recirculated and filtered at the top of the cleanroom. Cleanrooms maintain particulate-free air through the use of either HEPA or ULPA filters employing laminar or turbulent airflow principles. Laminar, or unidirectional, airflow systems direct filtered air downward or in horizontal direction in

484-554: A cleanroom in constant motion, although not all in the same direction. The rough air seeks to trap particles that may be in the air and drive them towards the floor, where they enter filters and leave the cleanroom environment. US FDA and EU have laid down stringent guidelines and limits to ensure freedom from microbial contamination in pharmaceutical products. Plenums between air handlers and fan filter units , along with sticky mats , may also be used. In addition to air filters, cleanrooms can also use ultraviolet light to disinfect

605-432: A cleanroom is usually restricted to those wearing a cleanroom suit , including the necessary machinery. In cleanrooms in which the standards of air contamination are less rigorous, the entrance to the cleanroom may not have an air shower. An anteroom (known as a "gray room") is used to put on cleanroom clothing. This practice is common in many nuclear power plants, which operate as low-grade inverse pressure cleanrooms, as

726-457: A cleanroom with factory floors covering thousands of square meters. Between the large and the small, there are also modular cleanrooms. They have been argued to lower costs of scaling the technology, and to be less susceptible to catastrophic failure. With such a wide area of application, not every cleanroom is the same. For example, the rooms utilized in semiconductor manufacturing need not be sterile (i.e., free of uncontrolled microbes), while

847-529: A constant stream towards filters located on walls near the cleanroom floor or through raised perforated floor panels to be recirculated. Laminar airflow systems are typically employed across 80% of a cleanroom ceiling to maintain constant air processing. Stainless steel or other non shedding materials are used to construct laminar airflow filters and hoods to prevent excess particles entering the air. Turbulent, or non-unidirectional, airflow uses both laminar airflow hoods and nonspecific velocity filters to keep air in

968-523: A cost of $ 2.5 million, the building was dedicated on July 20, 1979, the tenth anniversary of the first human Moon landing . The two-story, 1,300-square-meter (14,000 sq ft) facility consists of storage vaults for the samples, laboratories for sample preparation and study, a vault for sample data and records, and machinery to supply nitrogen to the cabinets in which the samples are stored and processed. The facility's storage vaults are elevated above anticipated storm-surge sea level heights to protect

1089-607: A decade of reliance on the Russians. In 2019, NASA announced the Artemis program , intending to return to the Moon and establish a permanent human presence. This was paired with the Artemis Accords with partner nations to establish rules of behavior and norms of space commercialization on the Moon. In 2023, NASA established the Moon to Mars Program office. The office is designed to oversee

1210-629: A month after the Soviet Yuri Gagarin became the first human in space, executing a full orbital spaceflight. NASA's first orbital spaceflight was conducted by John Glenn on February 20, 1962, in the Friendship 7 , making three full orbits before reentering. Glenn had to fly parts of his final two orbits manually due to an autopilot malfunction. The sixth and final Mercury mission was flown by Gordon Cooper in May 1963, performing 22 orbits over 34 hours in

1331-672: A new laboratory – the Sample Storage and Processing Laboratory (SSPL) – were built in Building 31 of the Johnson Space Center. All lunar samples were moved from the LRL to Building 31 after the last Apollo mission Nonetheless, there were still concerns about the adequacy of the facility and about the wisdom of maintaining the entire collection of lunar samples in a single facility that might be vulnerable to natural disasters (especially

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1452-453: A number of educational packs available for exhibition and educational purposes, each consisting of a disc of six small rock and soil samples in a lucite disc and a pack of thin petrological sections. In addition to the lunar samples returned by the Apollo missions, an additional 300 grams (11 oz) of lunar samples were returned to Earth by three automated Soviet spacecraft, Luna 16 , Luna 20 , and Luna 24 . Approximately 100 people visit

1573-570: A permanently manned space station and to do it within a decade. In 1985, NASA proposed the Space Station Freedom , which both the agency and President Reagan intended to be an international program. While this would add legitimacy to the program, there were concerns within NASA that the international component would dilute its authority within the project, having never been willing to work with domestic or international partners as true equals. There

1694-628: A possible source of antimatter at the center of the Milky Way and observing that the majority of gamma-ray bursts occur outside of the Milky Way galaxy. The Chandra X-ray Observatory was launched from the Columbia on STS-93 in 1999, observing black holes, quasars , supernova , and dark matter . It provided critical observations on the Sagittarius A* black hole at the center of the Milky Way galaxy and

1815-432: A reduced reliance on chemical disinfectants and the extension of HVAC filter life. Some cleanrooms are kept at a positive pressure so if any leaks occur, air leaks out of the chamber instead of unfiltered air coming in. This is most typically the case in semiconductor manufacturing, where even minute amounts of particulates leaking in could contaminate the whole process, while anything leaking out would not be harmful to

1936-404: A second step with light molecular weight solvents to clear. Cleanroom furniture is designed to produce a minimum of particles and is easy to clean. A cleanroom is as much a process and a meticulous culture to maintain, as it is a space as such. The greatest threat to cleanroom contamination comes from the users themselves. In the healthcare and pharmaceutical sectors, control of microorganisms

2057-483: A space station since the agency was created. In 1973, following the end of the Apollo lunar missions, NASA launched its first space station, Skylab , on the final launch of the Saturn   V. Skylab reused a significant amount of Apollo and Saturn hardware, with a repurposed Saturn   V third stage serving as the primary module for the space station. Damage to Skylab during its launch required spacewalks to be performed by

2178-584: A specially modified passenger bus. This smaller collection of materials remained at Brooks until 2002, when the base was transitioned from military control as part of the Base Realignment and Closure process. The second-site lunar materials were then moved to the White Sands Test Facility , where a new, smaller facility was built inside an existing secure building to house the samples. Of the 382 kilograms (842 lb) of lunar samples returned by

2299-524: A whole. Recirculating vs. one pass cleanrooms Recirculating cleanrooms return air to the negative pressure plenum via low wall air returns. The air then is pulled by HEPA fan filter units back into the cleanroom. The air is constantly recirculating and by continuously passing through HEPA filtration removing particles from the air each time. Another advantage of this design is that air conditioning can be incorporated. One pass cleanrooms draw air from outside and pass it through HEPA fan filter units into

2420-694: Is a biological hazard both ways: we must not contaminate any sample return missions from other stellar bodies with terrestrial microbes, and we must not contaminate possible other ecosystems existing in other planets. Thus, even by international law, any probes we send to outer space must be sterile, and so to be handled in cleanroom conditions. Since larger cleanrooms are very sensitive controlled environments upon which multibillion-dollar industries depend, sometimes they are even fitted with numerous seismic base isolation systems to prevent costly equipment malfunction. NASA The National Aeronautics and Space Administration ( NASA / ˈ n æ s ə / )

2541-427: Is a necessity in the manufacturing of semiconductors and rechargeable batteries , the life sciences , and any other field that is highly sensitive to environmental contamination. Cleanrooms can range from the very small to the very large. On the one hand, a single-user laboratory can be built to cleanroom standards within several square meters, and on the other, entire manufacturing facilities can be contained within

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2662-551: Is an independent agency of the U.S. federal government responsible for the civil space program , aeronautics research, and space research. Established in 1958 , it succeeded the National Advisory Committee for Aeronautics (NACA) to give the U.S. space development effort a distinct civilian orientation, emphasizing peaceful applications in space science . It has since led most of America's space exploration programs, including Project Mercury , Project Gemini ,

2783-466: Is an engineered space that maintains a very low concentration of airborne particulates . It is well isolated, well controlled from contamination , and actively cleansed. Such rooms are commonly needed for scientific research and in industrial production for all nanoscale processes, such as semiconductor manufacturing. A cleanroom is designed to keep everything from dust to airborne organisms or vaporised particles away from it, and so from whatever material

2904-431: Is being handled inside it. A cleanroom can also prevent the escape of materials. This is often the primary aim in hazardous biology , nuclear work , pharmaceutics and virology . Cleanrooms typically come with a cleanliness level quantified by the number of particles per cubic meter at a predetermined molecule measure. The ambient outdoor air in a typical urban area contains 35,000,000 particles for each cubic meter in

3025-592: Is expressed in the following table. These concentrations will lead to large air sample volumes for classification. Sequential sampling procedure may be applied; see Annex D. Concentration limits are not applicable in this region of the table due to very high particle concentration. Sampling and statistical limitations for particles in low concentrations make classification inappropriate. Sample collection limitations for both particles in low concentrations and sizes greater than 1 μm make classification at this particle size inappropriate due to potential particle losses in

3146-412: Is important, especially microorganisms likely to be deposited into the air stream from skin shedding . Studying cleanroom microflora is of importance for microbiologists and quality control personnel to assess changes in trends. Shifts in the types of microflora may indicate deviations from the "norm" such as resistant strains or problems with cleaning practices. In assessing cleanroom microorganisms,

3267-646: Is not carried out, but room AHU is on). BS 5295 is a British Standard . BS 5295 Class 1 also requires that the greatest particle present in any sample can not exceed 5 μm. BS 5295 has been superseded, withdrawn since the year 2007 and replaced with "BS EN ISO 14644-6:2007". USP 800 is a United States standard developed by the United States Pharmacopeial Convention (USP) with an effective date of December 1, 2019. In hospitals , theatres are similar to cleanrooms for surgical patients' operations with incisions to prevent any infections for

3388-453: Is preferred. Buffed stainless steel or powder-coated mild steel sandwich partition panels and ceiling panel are used instead of iron alloys prone to rusting and then flaking . Corners like the wall to wall, wall to floor, wall to ceiling are avoided by providing coved surface , and all joints need to be sealed with epoxy sealant to avoid any deposition or generation of particles at the joints, by vibration and friction . Many cleanrooms have

3509-583: The Faith 7 . The Mercury Program was wildly recognized as a resounding success, achieving its objectives to orbit a human in space, develop tracking and control systems, and identify other issues associated with human spaceflight. While much of NASA's attention turned to space, it did not put aside its aeronautics mission. Early aeronautics research attempted to build upon the X-1's supersonic flight to build an aircraft capable of hypersonic flight . The North American X-15

3630-720: The Army Ballistic Missile Agency would launch Explorer 1 , America's first satellite, on February 1, 1958. The Eisenhower Administration decided to split the United States' military and civil spaceflight programs, which were organized together under the Defense Department 's Advanced Research Projects Agency . NASA was established on July 29, 1958, with the signing of the National Aeronautics and Space Act and it began operations on October 1, 1958. As

3751-762: The Bell X-1 in a joint program with the U.S. Air Force . NACA's interest in space grew out of its rocketry program at the Pilotless Aircraft Research Division. The Soviet Union's launch of Sputnik 1 ushered in the Space Age and kicked off the Space Race . Despite NACA's early rocketry program, the responsibility for launching the first American satellite fell to the Naval Research Laboratory 's Project Vanguard , whose operational issues ensured

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3872-658: The Big Bang . The James Webb Space Telescope , named after the NASA administrator who lead the Apollo program, is an infrared observatory launched in 2021. The James Webb Space Telescope is a direct successor to the Hubble Space Telescope, intended to observe the formation of the first galaxies. Other space telescopes include the Kepler space telescope , launched in 2009 to identify planets orbiting extrasolar stars that may be Terran and possibly harbor life. The first exoplanet that

3993-660: The Earth Observing System ; advancing heliophysics through the efforts of the Science Mission Directorate 's Heliophysics Research Program; exploring bodies throughout the Solar System with advanced robotic spacecraft such as New Horizons and planetary rovers such as Perseverance ; and researching astrophysics topics, such as the Big Bang , through the James Webb Space Telescope ,

4114-753: The Environmental Science Services Administration on a series of weather satellites and the agency launched its experimental Applications Technology Satellites into geosynchronous orbit. NASA's first dedicated Earth observation satellite, Landsat , was launched in 1972. This led to NASA and the National Oceanic and Atmospheric Administration jointly developing the Geostationary Operational Environmental Satellite and discovering Ozone depletion . NASA had been pursuing spaceplane development since

4235-676: The Europa and observed that the moon may hold ice or liquid water. A joint NASA- European Space Agency - Italian Space Agency mission, Cassini–Huygens , was sent to Saturn 's moon Titan , which, along with Mars and Europa, are the only celestial bodies in the Solar System suspected of being capable of harboring life. Cassini discovered three new moons of Saturn and the Huygens probe entered Titan's atmosphere. The mission discovered evidence of liquid hydrocarbon lakes on Titan and subsurface water oceans on

4356-531: The International Organization for Standardization (ISO). The former applies to cleanrooms in general (see table below), the latter to cleanrooms where biocontamination may be an issue. Since the strictest standards have been achieved only for space applications, it is sometimes difficult to know whether they were achieved in vacuum or standard conditions. ISO 14644-1 defines the maximum concentration of particles per class and per particle size with

4477-742: The Johnson Space Center as the lead center for the design, development, and manufacturing of the Space Shuttle orbiter , while the Marshall Space Flight Center would lead the development of the launch system. NASA's series of lifting body aircraft, culminating in the joint NASA-U.S. Air Force Martin Marietta X-24 , directly informed the development of the Space Shuttle and future hypersonic flight aircraft. Official development of

4598-634: The Mars Global Surveyor orbiter and Mars Pathfinder , deploying the first Mars rover, Sojourner . During the early 2000s, the 2001 Mars Odyssey orbiter reached the planet and in 2004 the Sprit and Opportunity rovers landed on the Red Planet. This was followed in 2005 by the Mars Reconnaissance Orbiter and 2007 Phoenix Mars lander. The 2012 landing of Curiosity discovered that

4719-589: The Orbiting Geophysical Observatory in the 1960s and 1970s to look down at Earth and observe its interactions with the Sun. The Uhuru satellite was the first dedicated x-ray telescope, mapping 85% of the sky and discovering a large number of black holes . Launched in the 1990s and early 2000s, the Great Observatories program are among NASA's most powerful telescopes. The Hubble Space Telescope

4840-631: The STS-1 mission, designed to serve as a flight test for the new spaceplane. NASA intended for the Space Shuttle to replace expendable launch systems like the Air Force's Atlas , Delta , and Titan and the European Space Agency 's Ariane . The Space Shuttle's Spacelab payload, developed by the European Space Agency, increased the scientific capabilities of shuttle missions over anything NASA

4961-616: The STS-60 mission in 1994 and the Discovery rendezvoused, but did not dock with, the Russian Mir in the STS-63 mission. This was followed by Atlantis' STS-71 mission where it accomplished the initial intended mission for the Space Shuttle, docking with a space station and transferring supplies and personnel. The Shuttle- Mir program would continue until 1998, when a series of orbital accidents on

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5082-663: The Sandia National Laboratories , Whitfield created the initial plans for the cleanroom in 1960. Prior to Whitfield's invention, earlier cleanrooms often had problems with particles and unpredictable airflows . Whitfield designed his cleanroom with a constant, highly filtered airflow to flush out impurities. Within a few years of its invention in the 1960s, Whitfield's modern cleanroom had generated more than US$ 50 billion in sales worldwide (approximately $ 483 billion today). By mid-1963, more than 200 U.S. industrial plants had such specially constructed facilities—then using

5203-471: The Space Race when the Soviet Union gave up its lunar ambitions. As the first human to step on the surface of the Moon, Neil Armstrong uttered the now famous words: That's one small step for man, one giant leap for mankind. NASA would conduct six total lunar landings as part of the Apollo program, with Apollo   17 concluding the program in 1972. Wernher von Braun had advocated for NASA to develop

5324-609: The Space Shuttle began in 1972, with Rockwell International contracted to design the orbiter and engines, Martin Marietta for the external fuel tank , and Morton Thiokol for the solid rocket boosters . NASA acquired six orbiters: the Enterprise , Columbia , Challenger , Discovery , Atlantis , and Endeavour The Space Shuttle program also allowed NASA to make major changes to its Astronaut Corps . While almost all previous astronauts were Air Force or Naval test pilots,

5445-602: The United States Congress created the Aviation Section of the U.S. Army Signal Corps in 1914 and established NACA in 1915 to foster aeronautical research and development. Over the next forty years, NACA would conduct aeronautical research in support of the U.S. Air Force , U.S. Army , U.S. Navy , and the civil aviation sector. After the end of World War II , NACA became interested in the possibilities of guided missiles and supersonic aircraft, developing and testing

5566-671: The humidity to such low levels that extra equipment like air ionizers are required to prevent electrostatic discharge problems. This is a particular concern within the semiconductor business, because static discharge can easily damage modern circuit designs. On the other hand, active ions in the air can harm exposed components as well. Because of this, most workers in high electronics and semiconductor facilities have to wear conductive boots while working. Low-level cleanrooms may only require special shoes, with completely smooth soles that do not track in dust or dirt. However, for safety reasons, shoe soles must not create slipping hazards. Access to

5687-405: The inner planets . Despite these successes, Congress was unwilling to fund further interplanetary missions and NASA Administrator James Webb suspended all future interplanetary probes to focus resources on the Apollo program. Following the conclusion of the Apollo program, NASA resumed launching interplanetary probes and expanded its space science program. The first planet tagged for exploration

5808-425: The production of integrated circuits . William (Bill) C. McElroy Jr. worked as an engineering manager, drafting room supervisor, QA/QC, and designer for all three companies, and his designs added 45 original patents to the technology of the time. McElroy also wrote a four-page article for MicroContamination Journal, wet processing training manuals, and equipment manuals for wet processing and cleanrooms. A cleanroom

5929-516: The 1960s, blending the administration's dual aeronautics and space missions. NASA viewed a spaceplane as part of a larger program, providing routine and economical logistical support to a space station in Earth orbit that would be used as a hub for lunar and Mars missions. A reusable launch vehicle would then have ended the need for expensive and expendable boosters like the Saturn V . In 1969, NASA designated

6050-690: The 1968–1972 Apollo Moon landing missions, the Skylab space station, and the Space Shuttle . Currently, NASA supports the International Space Station (ISS) along with the Commercial Crew Program , and oversees the development of the Orion spacecraft and the Space Launch System for the lunar Artemis program . NASA's science division is focused on better understanding Earth through

6171-655: The 44 commercial companies that contracted with NASA to deploy their satellites to return to expendable launch vehicles. When the Space Shuttle returned to flight with the STS-26 mission, it had undergone significant modifications to improve its reliability and safety. Following the collapse of the Soviet Union, the Russian Federation and United States initiated the Shuttle- Mir program . The first Russian cosmonaut flew on

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6292-611: The Air Force as the military space lead. Plans for human spaceflight began in the U.S. Armed Forces prior to NASA's creation. The Air Force's Man in Space Soonest project formed in 1956, coupled with the Army's Project Adam, served as the foundation for Project Mercury . NASA established the Space Task Group to manage the program, which would conduct crewed sub-orbital flights with the Army's Redstone rockets and orbital flights with

6413-496: The Air Force's Atlas launch vehicles. While NASA intended for its first astronauts to be civilians, President Eisenhower directed that they be selected from the military. The Mercury 7 astronauts included three Air Force pilots, three Navy aviators, and one Marine Corps pilot. On May 5, 1961, Alan Shepard became the first American to enter space, performing a suborbital spaceflight in the Freedom 7 . This flight occurred less than

6534-518: The Apollo program, 52 kilograms (115 lb) are currently stored at White Sands. With a selection of the lunar samples secured offsite, construction began on the LSLF, with state-of-the-art facilities for handling the samples and better protection against natural disasters. The LSLF was constructed in a new annex of Building 31 (Building 31N at the Johnson Space Center) beginning in 1977. Built for

6655-410: The Apollo program. Despite attacks on the goal of landing astronauts on the Moon from the former president Dwight Eisenhower and 1964 presidential candidate Barry Goldwater , President Kennedy was able to protect NASA's growing budget, of which 50% went directly to human spaceflight and it was later estimated that, at its height, 5% of Americans worked on some aspect of the Apollo program. Mirroring

6776-660: The Army Ballistic Missile Agency's original Saturn   I . The Apollo spacecraft was designed and built by North American Aviation , while the Apollo Lunar Module was designed and built by Grumman . To develop the spaceflight skills and equipment required for a lunar mission, NASA initiated Project Gemini . Using a modified Air Force Titan   II launch vehicle, the Gemini capsule could hold two astronauts for flights of over two weeks. Gemini pioneered

6897-479: The Department of Defense's program management concept using redundant systems in building the first intercontinental ballistic missiles, NASA requested the Air Force assign Major General Samuel C. Phillips to the space agency where he would serve as the director of the Apollo program. Development of the Saturn   V rocket was led by Wernher von Braun and his team at the Marshall Space Flight Center , derived from

7018-415: The Johnson Space Center, built to process and conduct basic analysis on lunar materials and to quarantine the materials and astronauts. (The requirement that astronauts be quarantined following their missions was dropped beginning with Apollo 15 .) The 8,000-square-meter (86,000 sq ft) LRL was completed in 1967 at a cost of $ 7.8 million. The LRL was used for study, distribution and safe storage of

7139-558: The Keplar space telescope confirmed was Kepler-22b , orbiting within the habitable zone of its star. NASA also launched a number of different satellites to study Earth, such as Television Infrared Observation Satellite (TIROS) in 1960, which was the first weather satellite. NASA and the United States Weather Bureau cooperated on future TIROS and the second generation Nimbus program of weather satellites. It also worked with

7260-548: The Martian interior. The 2021 Perseverance rover carried the first extraplanetary aircraft, a helicopter named Ingenuity . NASA also launched missions to Mercury in 2004, with the MESSENGER probe demonstrating as the first use of a solar sail . NASA also launched probes to the outer Solar System starting in the 1960s. Pioneer 10 was the first probe to the outer planets, flying by Jupiter , while Pioneer 11 provided

7381-472: The Moon and going to Mars. Embracing this approach, NASA's Commercial Crew Program started by contracting cargo delivery to the International Space Station and flew its first operational contracted mission on SpaceX Crew-1 . This marked the first time since the retirement of the Space Shuttle that NASA was able to launch its own astronauts on an American spacecraft from the United States, ending

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7502-404: The Moon and returning him safely to Earth by the end of the 1960s and installed James E. Webb as NASA administrator to achieve this goal. On May   25, 1961, President Kennedy openly declared this goal in his "Urgent National Needs" speech to the United States Congress, declaring: I believe this Nation should commit itself to achieving the goal, before this decade is out, of landing a man on

7623-427: The Moon and returning him safely to Earth. No single space project in this period will be more impressive to mankind, or more important for the long-range exploration of space; and none will be so difficult or expensive to accomplish. Kennedy gave his " We choose to go to the Moon " speech the next year, on September   12, 1962 at Rice University , where he addressed the nation hoping to reinforce public support for

7744-529: The Moon itself. Also at the facility is the sample known as Big Muley , the largest sample returned from the Moon by Apollo. In addition to the Apollo materials, the Johnson Space Center also houses other extraterrestrial samples: 52 kilograms (115 lb) of the 382 kilograms (842 lb) of lunar samples returned by the Apollo program are stored at the White Sands Test Facility . Other small samples have been distributed to foreign heads of state, U.S. states, museums, and other institutions. NASA has also made

7865-456: The Moon will be brought back and processed and curated in the lab. The facility is the chief repository of the samples returned by the Apollo program. The Apollo missions to the lunar surface ( Apollo 11 , Apollo 12 , Apollo 14 , Apollo 15 , Apollo 16 , and Apollo 17 ) returned a total of 382 kilograms (842 pounds) of lunar rocks, core samples, pebbles, sand and lunar surface dust, comprising 2200 individual specimens. Seventy-five percent of

7986-409: The Russians be included. In 1993, the Clinton Administration announced that the Space Station Freedom would become the International Space Station in an agreement with the Russian Federation. This allowed the Russians to maintain their space program through an infusion of American currency to maintain their status as one of the two premier space programs. While the United States built and launched

8107-507: The Russians to fly to the International Space Station for four days, despite the opposition of NASA to the idea. Advocates of this new commercial approach for NASA included former astronaut Buzz Aldrin , who remarked that it would return NASA to its roots as a research and development agency, with commercial entities actually operating the space systems. Having corporations take over orbital operations would also allow NASA to focus all its efforts on deep space exploration and returning humans to

8228-422: The Solar System. Mars has long been a planet of intense fascination for NASA, being suspected of potentially having harbored life. Mariner 5 was the first NASA spacecraft to flyby Mars, followed by Mariner 6 and Mariner 7 . Mariner 9 was the first orbital mission to Mars. Launched in 1975, Viking program consisted of two landings on Mars in 1976. Follow-on missions would not be launched until 1996, with

8349-404: The Space Shuttle Columbia disaster in 2003, NASA was forced to rely on Russian Soyuz launches for its astronauts and the 2011 retirement of the Space Shuttle accelerated the station's completion. In the 1980s, right after the first flight of the Space Shuttle, NASA started a joint program with the Department of Defense to develop the Rockwell X-30 National Aerospace Plane. NASA realized that

8470-418: The Space Shuttle allowed NASA to begin recruiting more non-military scientific and technical experts. A prime example is Sally Ride , who became the first American woman to fly in space on STS-7 . This new astronaut selection process also allowed NASA to accept exchange astronauts from U.S. allies and partners for the first time. The first Space Shuttle flight occurred in 1981, when the Columbia launched on

8591-443: The Space Shuttle and expand space exploration beyond low Earth orbit. Constellation was intended to use a significant amount of former Space Shuttle equipment and return astronauts to the Moon. This program was canceled by the Obama Administration . Former astronauts Neil Armstrong , Gene Cernan , and Jim Lovell sent a letter to President Barack Obama to warn him that if the United States did not get new human spaceflight ability,

8712-544: The Space Shuttle began flying, selling it as an orbital laboratory, repair station, and a jumping off point for lunar and Mars missions. NASA found a strong advocate in President Ronald Reagan , who declared in a 1984 speech: America has always been greatest when we dared to be great. We can reach for greatness again. We can follow our dreams to distant stars, living and working in space for peaceful, economic, and scientific gain. Tonight I am directing NASA to develop

8833-660: The Space Shuttle, while a massive technological accomplishment, would not be able to live up to all its promises. Designed to be a single-stage-to-orbit spaceplane, the X-30 had both civil and military applications. With the end of the Cold War , the X-30 was canceled in 1992 before reaching flight status. Following the Space Shuttle Columbia disaster in 2003, President Bush started the Constellation program to smoothly replace

8954-483: The Space Shuttle. Due to technical challenges, the spacecraft was cancelled in 2001. Despite this, it was the first time a commercial space company directly expended a significant amount of its resources into spacecraft development. The advent of space tourism also forced NASA to challenge its assumption that only governments would have people in space. The first space tourist was Dennis Tito , an American investment manager and former aerospace engineer who contracted with

9075-571: The Space Station Freedom was controversial, with much of the debate centering on cost. Several redesigns to reduce cost were conducted in the early 1990s, stripping away much of its functions. Despite calls for Congress to terminate the program, it continued, in large part because by 1992 it had created 75,000 jobs across 39 states. By 1993, President Bill Clinton attempted to significantly reduce NASA's budget and directed costs be significantly reduced, aerospace industry jobs were not lost, and

9196-578: The U.S. risked become a second or third-rate space power. As early as the Reagan Administration, there had been calls for NASA to expand private sector involvement in space exploration rather than do it all in-house. In the 1990s, NASA and Lockheed Martin entered into an agreement to develop the Lockheed Martin X-33 demonstrator of the VentureStar spaceplane, which was intended to replace

9317-522: The US's premier aeronautics agency, NACA formed the core of NASA's new structure by reassigning 8,000 employees and three major research laboratories. NASA also proceeded to absorb the Naval Research Laboratory's Project Vanguard, the Army's Jet Propulsion Laboratory (JPL), and the Army Ballistic Missile Agency under Wernher von Braun . This left NASA firmly as the United States' civil space lead and

9438-405: The air using a corona discharge . Static discharge is of particular concern in the electronics industry, where it can instantly destroy components and circuitry. Equipment inside any cleanroom is designed to generate minimal air contamination. The selection of material for the construction of a cleanroom should not generate any particulates; hence, monolithic epoxy or polyurethane floor coating

9559-463: The air. UV devices can be fitted into ceiling light fixtures and irradiate air, killing potentially infectious particulates , including 99.99 percent of airborne microbial and fungal contaminants. UV light has previously been used to clean surface contaminants in sterile environments such as hospital operating rooms. Their use in other cleanrooms may increase as equipment becomes more affordable. Potential advantages of UV-based decontamination includes

9680-469: The astronauts and scientists involved in the program were skeptical that non-terrestrial microorganisms could survive lunar conditions). To address these issues, the committee in 1965 recommended a laboratory with limited analytical capacity and an ability to quarantine the returning astronauts and samples. The result of this planning was the Lunar Receiving Laboratory (LRL) in Building 37 at

9801-731: The cleanroom. The air then leaves through exhaust grills. The advantage of this approach is the lower cost. The disadvantages are comparatively shorter HEPA fan filter life, worse particle counts than a recirculating cleanroom, and that it cannot accommodate air conditioning. In order to minimize the carrying of particulate by a person moving into the cleanroom, staff enter and leave through airlocks (sometimes including an air shower stage) and wear protective clothing such as hoods , face masks, gloves, boots, and coveralls . Common materials such as paper , pencils , and fabrics made from natural fibers are often excluded because they shed particulates in use. Particle levels are usually tested using

9922-594: The compartment are also of concern, such as in research into dangerous viruses , or where radioactive materials are being handled. First, outside air entering a cleanroom is filtered and cooled by several outdoor air handlers using progressively finer filters to exclude dust. Within, air is constantly recirculated through fan units containing high-efficiency particulate absorbing filters ( HEPA ), and/or ultra-low particulate air ( ULPA ) filters to remove internally generated contaminants. Special lighting fixtures, walls, equipment and other materials are used to minimize

10043-405: The concentration is too low or too high to be practical to test for, but such blanks should not be read as zero. Because 1 m is about 35 ft , the two standards are mostly equivalent when measuring 0.5 μm particles, although the testing standards differ. Ordinary room air is around class 1,000,000 or ISO 9. ISO 14644-1 and ISO 14698 are non-governmental standards developed by

10164-590: The concentration of airborne particles, equal to and larger than the specified sizes, at designated sampling locations. Small numbers refer to ISO 14644-1 standards, which specify the decimal logarithm of the number of particles 0.1 μm or larger permitted per m of air. So, for example, an ISO class 5 cleanroom has at most 10 particles/m . Both FS 209E and ISO 14644-1 assume log-log relationships between particle size and particle concentration. For that reason, zero particle concentration does not exist. Some classes do not require testing some particle sizes, because

10285-531: The considered particle size which is rounded to the nearest whole number, using no more than three significant figures, N {\displaystyle {\text{N}}} is the ISO class number, D {\displaystyle {\text{D}}} is the size of the particle in μ {\displaystyle \mu } m and 0.1 is a constant expressed in μ {\displaystyle \mu } m. The result for standard particle sizes

10406-472: The facility annually for research or educational purposes, and the facility provides samples to hundreds of others each year for research or educational purposes. Researchers seeking samples submit proposals, which are evaluated by an independent peer review panel. 40 to 50 such proposals are approved each year and approximately 400 lunar samples (most weighing less than one gram) are sent to these scientists. Cleanroom A cleanroom or clean room

10527-420: The first close up view of the planet. Both probes became the first objects to leave the Solar System. The Voyager program launched in 1977, conducting flybys of Jupiter and Saturn , Neptune , and Uranus on a trajectory to leave the Solar System. The Galileo spacecraft, deployed from the Space Shuttle flight STS-34 , was the first spacecraft to orbit Jupiter, discovering evidence of subsurface oceans on

10648-510: The first crew to make it habitable and operational. Skylab hosted nine missions and was decommissioned in 1974 and deorbited in 1979, two years prior to the first launch of the Space Shuttle and any possibility of boosting its orbit. In 1975, the Apollo–Soyuz mission was the first ever international spaceflight and a major diplomatic accomplishment between the Cold War rivals, which also marked

10769-402: The first humans to see the Earth as a globe in space, the first to witness an Earthrise , and the first to see and manually photograph the far side of the Moon. The first lunar landing was conducted by Apollo   11. Commanded by Neil Armstrong with astronauts Buzz Aldrin and Michael Collins , Apollo   11 was one of the most significant missions in NASA's history, marking the end of

10890-506: The following formula C N = 10 N ( 0.1 D ) 2.08 {\displaystyle {\text{C}}_{\text{N}}=10^{\text{N}}\left({\frac {0.1}{\text{D}}}\right)^{2.08}} Where C N {\displaystyle {\text{C}}_{\text{N}}} is the maximum concentration of particles in a volume of 1m 3 {\displaystyle ^{3}} of airborne particles that are equal to, or larger, than

11011-465: The four Great Observatories , and associated programs. The Launch Services Program oversees launch operations for its uncrewed launches . NASA traces its roots to the National Advisory Committee for Aeronautics (NACA). Despite being the birthplace of aviation, by 1914 the United States recognized that it was far behind Europe in aviation capability. Determined to regain American leadership in aviation,

11132-475: The generation of airborne particles. Plastic sheets can be used to restrict air turbulence if the cleanroom design is of the laminar airflow type. Air temperature and humidity levels inside a cleanroom are tightly controlled, because they affect the efficiency and means of air filtration. If a particular room requires low enough humidity to make static electricity a concern, it too will be controlled by, e.g., introducing controlled amounts of charged ions into

11253-466: The hurricanes to which Houston is vulnerable) and military actions. The collection was divided among multiple vaults at the Johnson Space Center while a vault was built in an empty ammunition bunker at Brooks Air Force Base in San Antonio, Texas , as second-site storage. Fourteen percent of the lunar sample collection was moved to this bunker in 1976, transported secretly at night with a police escort in

11374-523: The integrated circuit manufacturing facilities in Silicon Valley were made by three companies: MicroAire, PureAire, and Key Plastics. These competitors made laminar flow units, glove boxes, cleanrooms and air showers , along with the chemical tanks and benches used in the "wet process" building of integrated circuits. These three companies were the pioneers of the use of Teflon for airguns, chemical pumps, scrubbers, water guns, and other devices needed for

11495-451: The last flight of the Apollo capsule. Flown in 1975, a U.S. Apollo spacecraft docked with a Soviet Soyuz capsule. During the 1960s, NASA started its space science and interplanetary probe program. The Mariner program was its flagship program, launching probes to Venus , Mars , and Mercury in the 1960s. The Jet Propulsion Laboratory was the lead NASA center for robotic interplanetary exploration, making significant discoveries about

11616-549: The lunar materials returned by Apollo are housed at the Lunar Sample Laboratory Facility, most in pristine condition. Some of the materials have been processed into smaller samples to meet scientific requirements, resulting in more than 110,000 individually cataloged samples. Perhaps the most notable of the samples stored at the facility is the Genesis Rock , a sample ultimately determined to be nearly as old as

11737-434: The majority of the International Space Station, Russia, Canada, Japan, and the European Space Agency all contributed components. Despite NASA's insistence that costs would be kept at a budget of $ 17.4, they kept rising and NASA had to transfer funds from other programs to keep the International Space Station solvent. Ultimately, the total cost of the station was $ 150 billion, with the United States paying for two-thirds.Following

11858-609: The moon of Enceladus , which could harbor life. Finally launched in 2006, the New Horizons mission was the first spacecraft to visit Pluto and the Kuiper Belt . Beyond interplanetary probes, NASA has launched many space telescopes . Launched in the 1960s, the Orbiting Astronomical Observatory were NASA's first orbital telescopes, providing ultraviolet, gamma-ray, x-ray, and infrared observations. NASA launched

11979-411: The number and size of particles permitted per volume of air. Large numbers like "class 100" or "class 1000" refer to FED-STD-209E , and denote the number of particles of size 0.5 μm or larger permitted per cubic foot of air. The standard also allows interpolation; for example SNOLAB is maintained as a class 2000 cleanroom. A discrete, light-scattering airborne particle counter is used to determine

12100-438: The ones used in biotechnology usually must be. Vice versa, operating rooms need not be absolutely pure of nanoscale inorganic salts, such as rust , while nanotechnology absolutely requires it. What then is common to all cleanrooms is strict control of airborne particulates , possibly with secondary decontamination of air, surfaces, workers entering the room, implements, chemicals, and machinery. Sometimes particulates exiting

12221-425: The patient. In another case, severely immunocompromised patients sometimes have to be held in prolonged isolation from their surroundings, for fear of infection. At the extreme, this necessitates a cleanroom environment. The same is the case for patients carrying airborne infectious diseases, only they are handled at negative, not positive pressure. In exobiology when we seek out contact with other planets, there

12342-558: The radiation levels on Mars were equal to those on the International Space Station , greatly increasing the possibility of Human exploration, and observed the key chemical ingredients for life to occur. In 2013, the Mars Atmosphere and Volatile Evolution ( MAVEN ) mission observed the Martian upper atmosphere and space environment and in 2018, the Interior exploration using Seismic Investigations Geodesy, and Heat Transport ( InSight ) studied

12463-403: The samples from threats posed by hurricanes and tornadoes. During hurricane threats, a water-tight door is bolted into the frame of the door to the pristine sample vault in order to protect the samples. The facility takes extensive measures to prevent contamination of the lunar samples. For example: The facility has room to store many more lunar samples. NASA anticipates that more samples from

12584-423: The samples, but although the LRL had adequate facilities to process samples for the current mission, the facility was not ideal, and it lacked facilities to process or store samples from previous missions. To address some of these concerns, NASA dropped the requirement after Apollo 12 that samples be processed in vacuum (in favor of a simpler-to-work-in nitrogen atmosphere). An additional vault and, subsequently,

12705-703: The samples. A committee of the Space Science Board reviewed the idea of a lunar sample receiving laboratory and sought to address multiple concerns. One was the fear that creating a facility with too great a capacity to analyze the samples would discourage distribution of samples to outside researchers and effectively exclude them. In addition, space biologists and the United States Public Health Service expressed concern about " back contamination " of Earth by extraterrestrial microorganisms brought back via returning spacecraft, (although many of

12826-557: The sampling system. US FED-STD-209E was a United States federal standard. It was officially cancelled by the General Services Administration on November 29, 2001, but is still widely used. Current regulating bodies include ISO, USP 800, US FED STD 209E (previous standard, still used). EU GMP guidelines are more stringent than others, requiring cleanrooms to meet particle counts at operation (during manufacturing process) and at rest (when manufacturing process

12947-502: The satellites were repaired and relaunched. Despite ushering in a new era of spaceflight, where NASA was contracting launch services to commercial companies, the Space Shuttle was criticized for not being as reusable and cost-effective as advertised. In 1986, Challenger disaster on the STS-51L mission resulted in the loss of the spacecraft and all seven astronauts on launch, grounding the entire space shuttle fleet for 36 months and forced

13068-641: The separation of dark and regular matter during galactic collisions. Finally, the Spitzer Space Telescope is an infrared telescope launched in 2003 from a Delta II rocket. It is in a trailing orbit around the Sun, following the Earth and discovered the existence of brown dwarf stars . Other telescopes, such as the Cosmic Background Explorer and the Wilkinson Microwave Anisotropy Probe , provided evidence to support

13189-552: The setback caused by the Apollo   1 fire, which killed three astronauts, the program proceeded. Apollo   8 was the first crewed spacecraft to leave low Earth orbit and the first human spaceflight to reach the Moon . The crew orbited the Moon ten times on December   24 and   25, 1968, and then traveled safely back to Earth . The three Apollo   8 astronauts— Frank Borman , James Lovell , and William Anders —were

13310-447: The size range 0.5 μm and bigger, equivalent to an ISO 9 certified cleanroom. By comparison, an ISO 14644 -1 level 1 certified cleanroom permits no particles in that size range, and just 12 particles for each cubic meter of 0.3 μm and smaller. Semiconductor facilities often get by with level 7 or 5, while level 1 facilities are exceedingly rare. The modern cleanroom was invented by American physicist Willis Whitfield . As an employee of

13431-534: The space shuttle be retired. In 2006, the Space Shuttle returned to flight, conducting several mission to service the Hubble Space Telescope , but was retired following the STS-135 resupply mission to the International Space Station in 2011. NASA never gave up on the idea of a space station after Skylab's reentry in 1979. The agency began lobbying politicians to support building a larger space station as soon as

13552-476: The space station spelled an end to the program. In 2003, a second space shuttle was destroyed when the Columbia was destroyed upon reentry during the STS-107 mission, resulting in the loss of the spacecraft and all seven astronauts. This accident marked the beginning of the retiring of the Space Shuttle program, with President George W. Bush directing that upon the completion of the International Space Station,

13673-428: The surrounding community . The opposite is done, e.g., in the case of high-level bio-laboratories that handle dangerous bacteria or viruses; those are always held at negative pressure , with the exhaust being passed through high-efficiency filters, and further sterilizing procedures. Both are still cleanrooms because the particulate level inside is maintained within very low limits. Some cleanroom HVAC systems control

13794-614: The terminology “White Rooms,” “Clean Rooms,” or “Dust-Free Rooms”—including the Radio Corporation of America, McDonnell Aircraft, Hughes Aircraft, Sperry Rand, Sylvania Electric, Western Electric, Boeing, and North American Aviation. RCA began such a conversion of part of its Cambridge, Ohio facilities in February 1961. Totalling 70,000 square feet, it was used to prepare control equipment for the Minuteman ICBM missiles. The majority of

13915-470: The typical flora are primarily those associated with human skin ( Gram-positive cocci ), although microorganisms from other sources such as the environment ( Gram-positive rods ) and water ( Gram-negative rods ) are also detected, although in lower number. Common bacterial genera include Micrococcus , Staphylococcus , Corynebacterium , and Bacillus , and fungal genera include Aspergillus and Penicillium . Cleanrooms are classified according to

14036-579: The use of fuel cells instead of batteries, and conducted the first American spacewalks and rendezvous operations . The Ranger Program was started in the 1950s as a response to Soviet lunar exploration, however most missions ended in failure. The Lunar Orbiter program had greater success, mapping the surface in preparation for Apollo landings and measured Selenography , conducted meteoroid detection, and measured radiation levels. The Surveyor program conducted uncrewed lunar landings and takeoffs, as well as taking surface and regolith observations. Despite

14157-454: Was Venus , sharing many similar characteristics to Earth. First visited by American Mariner 2 spacecraft, Venus was observed to be a hot and inhospitable planet. Follow-on missions included the Pioneer Venus project in the 1970s and Magellan , which performed radar mapping of Venus' surface in the 1980s and 1990s. Future missions were flybys of Venus, on their way to other destinations in

14278-434: Was a joint NASA–U.S. Air Force program, with the hypersonic test aircraft becoming the first non-dedicated spacecraft to cross from the atmosphere to outer space. The X-15 also served as a testbed for Apollo program technologies, as well as ramjet and scramjet propulsion. Escalations in the Cold War between the United States and Soviet Union prompted President John F. Kennedy to charge NASA with landing an American on

14399-663: Was able to previously accomplish. NASA launched its first commercial satellites on the STS-5 mission and in 1984, the STS-41-C mission conducted the world's first on-orbit satellite servicing mission when the Challenger captured and repaired the malfunctioning Solar Maximum Mission satellite. It also had the capability to return malfunctioning satellite to Earth, like it did with the Palapa B2 and Westar 6 satellites. Once returned to Earth,

14520-467: Was also a concern with sharing sensitive space technologies with the Europeans, which had the potential to dilute America's technical lead. Ultimately, an international agreement to develop the Space Station Freedom program would be signed with thirteen countries in 1985, including the European Space Agency member states, Canada , and Japan . Despite its status as the first international space program,

14641-492: Was launched in 1990 on STS-31 from the Discovery and could view galaxies 15 billion light years away. A major defect in the telescope's mirror could have crippled the program, had NASA not used computer enhancement to compensate for the imperfection and launched five Space Shuttle servicing flights to replace the damaged components. The Compton Gamma Ray Observatory was launched from the Atlantis on STS-37 in 1991, discovering

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