143-545: STS-63 was the second mission of the US/Russian Shuttle-Mir Program and the 20th flight of Discovery, which carried out the first rendezvous of the American Space Shuttle with Russia's space station Mir . Known as the 'Near-Mir' mission, the flight used Space Shuttle Discovery , which lifted off from launch pad 39B on February 3, 1995, from Kennedy Space Center , Florida. A night launch and
286-617: A 10- to 20-fold reduction in transmission risk. Pre-exposure prophylaxis for HIV (" PrEP ") with a daily dose of the medications tenofovir , with or without emtricitabine , is effective in people at high risk including men who have sex with men, couples where one is HIV-positive, and young heterosexuals in Africa. It may also be effective in intravenous drug users, with a study finding a decrease in risk of 0.7 to 0.4 per 100 person years. The USPSTF , in 2019, recommended PrEP in those who are at high risk. Universal precautions within
429-441: A Russian Orlan spacesuit . The program was marred by various concerns, notably the safety of Mir following a fire, a Russian spacecraft colliding with Spektr rendering it uninhabitable, financial issues with the cash-strapped Russian space program and worries from astronauts about the attitudes of the program administrators. Nevertheless, a large amount of science, expertise in space station construction and knowledge in working in
572-457: A Soviet Soyuz spacecraft. This was followed by the talks between NASA and Intercosmos in the 1970s about a "Shuttle– Salyut " program to fly Space Shuttle missions to a Salyut space station , with later talks in the 1980s even considering flights of the future Soviet shuttles from the Buran programme to a future US space station – this "Shuttle– Salyut " program never materialized however during
715-678: A UK-born astronaut and an African-American astronaut, lasted 4 hours, 38 minutes. Other payloads: Along with ODERACS-II, the Cryo System Experiment (CSE) and Shuttle Glow (GLO-2) payloads were mounted on the Hitchhiker support assembly in cargo bay; an IMAX camera was also located here. In middeck, the Solid Surface Combustion Experiment (SSCE) flew for the eighth time. The Air Force Maui Optical Site (AMOS) test required no onboard hardware. BioServe Space Technologies at
858-529: A brief period of influenza-like illness . During this period the person may not know that they are HIV-positive, yet they will be able to pass on the virus . Typically, this period is followed by a prolonged incubation period with no symptoms. Eventually the HIV infection increases the risk of developing other infections such as tuberculosis , as well as other opportunistic infections , and tumors which are rare in people who have normal immune function. The late stage
1001-458: A complex that was the world's largest spacecraft at that time, with a combined mass of 250 metric tons (250 long tons ; 280 short tons ). The Space Shuttle was a partially reusable low Earth orbital spacecraft system that was operated from 1981 to 2011 by the U.S. National Aeronautics and Space Administration (NASA) as part of the Space Shuttle program . Its official program name
1144-570: A cooperative space venture was gained from the combined operations, allowing the construction of the ISS to proceed much more smoothly than would have otherwise been the case. The origins of the Shuttle– Mir program can be traced back to the 1975 Apollo–Soyuz Test Project , that resulted in a joint US/Soviet mission during the détente period of the Cold War and the docking between a US Apollo spacecraft and
1287-406: A couple in which one person is infected, the rate of HIV infection is less than 1% per year. There is some evidence to suggest that female condoms may provide an equivalent level of protection. Application of a vaginal gel containing tenofovir (a reverse transcriptase inhibitor ) immediately before sex seems to reduce infection rates by approximately 40% among African women. By contrast, use of
1430-589: A diplomatic channel for NASA to take part in the funding of the cripplingly under-funded Russian space program. This in turn allowed the newly fledged Russian government to keep Mir operating, in addition to the Russian space program as a whole, ensuring the Russian government remained friendly towards the United States. In addition to the flights of the Shuttle to Mir , Phase One also featured seven "Increments" aboard
1573-448: A factor. During the chronic phase, the consequences of generalized immune activation coupled with the gradual loss of the ability of the immune system to generate new T cells appear to account for the slow decline in CD4 T cell numbers. Although the symptoms of immune deficiency characteristic of AIDS do not appear for years after a person is infected, the bulk of CD4 T cell loss occurs during
SECTION 10
#17328452650541716-761: A five-hour spacewalk. Payloads flying aboard STS-63 included the Cryo Systems Experiment (CSE), the Shuttle Glow (GLO-2) experiment, Orbital Debris Radar Calibration Spheres (ODERACS-2), the Solid Surface Combustion Experiment (SSCE), the Air Force Maui Optical Site Calibration Test (AMOS) and the Midcourse Space Experiment (MSX). Beginning on flight day one, a series of thruster burns were performed daily to bring Discovery in line with Mir . The original plan called for
1859-404: A high viral load and the cut was deep. In the United States, intravenous drug users made up 12% of all new cases of HIV in 2009, and in some areas more than 80% of people who inject drugs are HIV-positive. HIV is transmitted in about 90% of blood transfusions using infected blood. In developed countries the risk of acquiring HIV from a blood transfusion is extremely low (less than one in half
2002-567: A known tendency of spaceflight to weaken the immune system, the Immune experiment tested the ability of a particular substance to prevent or reduce this weakening. Clinical applications could include treatment of individuals suffering from such immunosuppressant diseases as acquired immunodeficiency syndrome . On flight day two, the crew deployed the Orbital Debris Radar Calibration System-II (ODERACS-II) to help characterize
2145-630: A large truss structure that spans 109 metres (358 ft), making it the largest spacecraft ever assembled. The completed station consists of five laboratories and is able to support six crew members. With over 332 cubic metres (11,700 cu ft) of habitable volume and a mass of 400,000 kilograms (880,000 lb) the completed station is almost twice the size of the combined Shuttle– Mir spacecraft. Phases Two and Three are intended to continue both international cooperation in space and zero-gravity scientific research, particularly regarding long-duration spaceflight. By spring 2015, Roscosmos , NASA, and
2288-402: A long incubation period . Lentiviruses are transmitted as single-stranded, positive- sense , enveloped RNA viruses . Upon entry into the target cell, the viral RNA genome is converted (reverse transcribed) into double-stranded DNA by a virally encoded reverse transcriptase that is transported along with the viral genome in the virus particle. The resulting viral DNA is then imported into
2431-538: A million) where improved donor selection and HIV screening is performed; for example, in the UK the risk is reported at one in five million and in the United States it was one in 1.5 million in 2008. In low-income countries, only half of transfusions may be appropriately screened (as of 2008), and it is estimated that up to 15% of HIV infections in these areas come from transfusion of infected blood and blood products, representing between 5% and 10% of global infections. It
2574-483: A near collision with a Progress resupply cargo ship during a long-distance manual docking system test and a total loss of station electrical power. The power failure also caused a loss of attitude control , which led to an uncontrolled "tumble" through space. The next NASA astronaut to stay on Mir was Michael Foale . Foale and Russian mission specialist Elena Kondakova boarded Mir from Atlantis on mission STS-84 . The STS-84 crew transferred 249 items between
2717-401: A needle during drug injection is between 0.63% and 2.4% per act, with an average of 0.8%. The risk of acquiring HIV from a needle stick from an HIV-infected person is estimated as 0.3% (about 1 in 333) per act and the risk following mucous membrane exposure to infected blood as 0.09% (about 1 in 1000) per act. This risk may, however, be up to 5% if the introduced blood was from a person with
2860-521: A new space station, which eventually became the International Space Station. They also agreed, in preparation for this new project, that the United States would be heavily involved in the Mir project in the years ahead, under the code name "Phase One" (the construction of the ISS being "Phase Two"). The first Space Shuttle flight to Mir was a rendezvous mission without docking on STS-63 . This
3003-468: A normal life, and die with the virus, not of it. Effective treatment for HIV-positive people (people living with HIV ) involves a life-long regimen of medicine to suppress the virus, making the viral load undetectable. Without treatment it can lead to a spectrum of conditions including acquired immunodeficiency syndrome ( AIDS ). Treatment is recommended as soon as the diagnosis is made. An HIV-positive person who has an undetectable viral load as
SECTION 20
#17328452650543146-616: A process of cell-to-cell spread. The hybrid spreading mechanisms of HIV contribute to the virus' ongoing replication against antiretroviral therapies. Two types of HIV have been characterized: HIV-1 and HIV-2. HIV-1 is the virus that was originally discovered (and initially referred to also as LAV or HTLV-III). It is more virulent , more infective , and is the cause of the majority of HIV infections globally. The lower infectivity of HIV-2 as compared with HIV-1 implies that fewer people exposed to HIV-2 will be infected per exposure. Because of its relatively poor capacity for transmission, HIV-2
3289-430: A result of long-term treatment has effectively no risk of transmitting HIV sexually. Campaigns by UNAIDS and organizations around the world have communicated this as Undetectable = Untransmittable . Without treatment the infection can interfere with the immune system , and eventually progress to AIDS , sometimes taking many years. Following initial infection an individual may not notice any symptoms, or may experience
3432-406: A sexually transmitted illness. In many areas of the world, a third of HIV carriers only discover they are infected at an advanced stage of the disease when AIDS or severe immunodeficiency has become apparent. Most people infected with HIV develop seroconverted (antigen-specific) antibodies within three to twelve weeks after the initial infection. Diagnosis of primary HIV before seroconversion
3575-625: A spirit of cooperation between the two nations and their space agencies , the National Aeronautics and Space Administration (NASA) and the Russian Space Agency (PKA). The project helped to prepare the way for further cooperative space ventures; specifically, "Phase Two" of the joint project, the construction of the International Space Station (ISS). The program was announced in 1993, the first mission started in 1994 and
3718-427: Is a retrovirus that attacks the immune system . It is a preventable disease . There is no vaccine or cure for HIV. It can be managed with treatment and become a manageable chronic health condition. While there is no cure or vaccine, antiretroviral treatment can slow the course of the disease and enable people living with HIV to lead long and healthy lives. An HIV-positive person on treatment can expect to live
3861-433: Is almost invariably associated with activation of CD8 T cells , which kill HIV-infected cells, and subsequently with antibody production, or seroconversion . The CD8 T cell response is thought to be important in controlling virus levels, which peak and then decline, as the CD4 T cell counts recover. A good CD8 T cell response has been linked to slower disease progression and a better prognosis, though it does not eliminate
4004-538: Is also believed to carry an increased risk of HIV transmission as condoms are rarely worn, physical trauma to the vagina or rectum is likely, and there may be a greater risk of concurrent sexually transmitted infections. The second-most frequent mode of HIV transmission is via blood and blood products. Blood-borne transmission can be through needle-sharing during intravenous drug use, needle-stick injury, transfusion of contaminated blood or blood product, or medical injections with unsterilized equipment. The risk from sharing
4147-478: Is called acute HIV, primary HIV or acute retroviral syndrome. Many individuals develop an illness like influenza , mononucleosis or glandular fever 2–4 weeks after exposure while others have no significant symptoms. Symptoms occur in 40–90% of cases and most commonly include fever , large tender lymph nodes , throat inflammation , a rash , headache, tiredness, and/or sores of the mouth and genitals. The rash, which occurs in 20–50% of cases, presents itself on
4290-653: Is defined as an HIV infection with either a CD4 T cell count below 200 cells per μL or the occurrence of specific diseases associated with HIV infection. In the absence of specific treatment, around half of people infected with HIV develop AIDS within ten years. The most common initial conditions that alert to the presence of AIDS are pneumocystis pneumonia (40%), cachexia in the form of HIV wasting syndrome (20%), and esophageal candidiasis . Other common signs include recurrent respiratory tract infections . Opportunistic infections may be caused by bacteria , viruses , fungi , and parasites that are normally controlled by
4433-760: Is disputed, and whether it is of benefit in developed countries and among men who have sex with men is undetermined. Programs encouraging sexual abstinence do not appear to affect subsequent HIV risk. Evidence of any benefit from peer education is equally poor. Comprehensive sexual education provided at school may decrease high-risk behavior. A substantial minority of young people continues to engage in high-risk practices despite knowing about HIV/AIDS, underestimating their own risk of becoming infected with HIV. Voluntary counseling and testing people for HIV does not affect risky behavior in those who test negative but does increase condom use in those who test positive. Enhanced family planning services appear to increase
STS-63 - Misplaced Pages Continue
4576-422: Is done by measuring HIV- RNA or p24 antigen . Positive results obtained by antibody or PCR testing are confirmed either by a different antibody or by PCR. Antibody tests in children younger than 18 months are typically inaccurate, due to the continued presence of maternal antibodies . Thus HIV infection can only be diagnosed by PCR testing for HIV RNA or DNA, or via testing for the p24 antigen. Much of
4719-595: Is especially high, estimated as 1.4–1.7% per act in both heterosexual and homosexual contacts. While the risk of transmission from oral sex is relatively low, it is still present. The risk from receiving oral sex has been described as "nearly nil"; however, a few cases have been reported. The per-act risk is estimated at 0–0.04% for receptive oral intercourse. In settings involving prostitution in low-income countries, risk of female-to-male transmission has been estimated as 2.4% per act, and of male-to-female transmission as 0.05% per act. Risk of transmission increases in
4862-400: Is largely confined to West Africa . After the virus enters the body, there is a period of rapid viral replication , leading to an abundance of virus in the peripheral blood. During primary infection, the level of HIV may reach several million virus particles per milliliter of blood. This response is accompanied by a marked drop in the number of circulating CD4 T cells . The acute viremia
5005-531: Is often also associated with unintended weight loss . Without treatment a person living with HIV can expect to live for 11 years. Early testing can show if treatment is needed to stop this progression and to prevent infecting others. HIV is spread primarily by unprotected sex (including anal and vaginal sex ), contaminated hypodermic needles or blood transfusions , and from mother to child during pregnancy , delivery, or breastfeeding. Some bodily fluids, such as saliva, sweat, and tears, do not transmit
5148-562: Is possible to acquire HIV from organ and tissue transplantation , although this is rare because of screening . Unsafe medical injections play a role in HIV spread in sub-Saharan Africa . In 2007, between 12% and 17% of infections in this region were attributed to medical syringe use. The World Health Organization estimates the risk of transmission as a result of a medical injection in Africa at 1.2%. Risks are also associated with invasive procedures, assisted delivery, and dental care in this area of
5291-420: Is referred to as post-exposure prophylaxis (PEP). The use of the single agent zidovudine reduces the risk of an HIV infection five-fold following a needle-stick injury. As of 2013 , the prevention regimen recommended in the United States consists of three medications— tenofovir , emtricitabine and raltegravir —as this may reduce the risk further. PEP treatment is recommended after a sexual assault when
5434-542: Is spread by three main routes: sexual contact , significant exposure to infected body fluids or tissues, and from mother to child during pregnancy, delivery, or breastfeeding (known as vertical transmission ). There is no risk of acquiring HIV if exposed to feces , nasal secretions, saliva, sputum , sweat, tears, urine, or vomit unless these are contaminated with blood. It is also possible to be co-infected by more than one strain of HIV—a condition known as HIV superinfection . The most frequent mode of transmission of HIV
5577-467: Is through sexual contact with an infected person. However, an HIV-positive person who has an undetectable viral load as a result of long-term treatment has effectively no risk of transmitting HIV sexually, known as Undetectable = Untransmittable . The existence of functionally noncontagious HIV-positive people on antiretroviral therapy was controversially publicized in the 2008 Swiss Statement , and has since become accepted as medically sound. Globally,
5720-548: The Canadian Space Agency (CSA) have agreed to extend the ISS's mission from 2020 to 2024. In 2018 that was then extended out to 2030. The results of this research will provide considerable information for long-duration expeditions to the Moon and flights to Mars . Following the intentional deorbiting of Mir on 23 March 2001, the ISS became the only space station in orbit around Earth. It retained that distinction until
5863-570: The Earth . They also assisted in the maintenance and repair of the aging station, following various incidents with fires, collisions, power losses, uncontrolled spins and toxic leaks. In all, the American astronauts would spend almost a thousand days aboard Mir , allowing NASA to learn a great deal about long-duration spaceflight, particularly in the areas of astronaut psychology and how best to arrange experiment schedules for crews aboard space stations. Mir
STS-63 - Misplaced Pages Continue
6006-647: The International Space Station . Lucid became the first American woman to live on station, and, following a six-week extension to her Increment due to issues with Shuttle Solid Rocket Boosters , her 188-day mission set the US single spaceflight record. During Lucid's time aboard Mir , the Priroda module, with about 2,200 pounds (1,000 kg) of US science hardware, was docked to Mir . Lucid made use of both Priroda and Spektr to carry out 28 different science experiments and as living quarters. Her stay aboard Mir ended with
6149-826: The Kennedy Space Center (KSC) in Florida. The Shuttle fleet's total mission time was 1322 days, 19 hours, 21 minutes and 23 seconds. The Space Shuttle carried large payloads to various orbits, and, during the Shuttle– Mir and ISS programs, provided crew rotation and carried various supplies, modules and pieces of equipment to the stations. Each Shuttle was designed for a projected lifespan of 100 launches or 10 years' operational life. Nine docking missions were flown to Mir , from 1995 to 1997 during "Phase One": Space Shuttle Atlantis docked seven times to Mir , with Discovery and Endeavour each flying one docking mission to Mir . As Space Shuttle Columbia
6292-519: The Priroda module (launched in 1996), making them de facto U.S. modules during the duration of the Shuttle- Mir program. During the four-year program, many firsts in spaceflight were achieved by the two nations, including the first American astronaut to launch aboard a Soyuz spacecraft, the largest spacecraft ever to have been assembled at that time in history, and the first American spacewalk using
6435-581: The WHO disease staging system for HIV infection and disease , and the CDC classification system for HIV infection . The CDC's classification system is more frequently adopted in developed countries. Since the WHO's staging system does not require laboratory tests, it is suited to the resource-restricted conditions encountered in developing countries, where it can also be used to help guide clinical management. Despite their differences,
6578-603: The World Health Organization (WHO) African Region. HIV/AIDS is considered a pandemic —a disease outbreak which is present over a large area and is actively spreading. The United States' National Institutes of Health (NIH) and the Gates Foundation have pledged $ 200 million focused on developing a global cure for AIDS. There are three main stages of HIV infection: acute infection, clinical latency, and AIDS. The initial period following infection with HIV
6721-598: The spermicide nonoxynol-9 may increase the risk of transmission due to its tendency to cause vaginal and rectal irritation. Circumcision in sub-Saharan Africa "reduces the acquisition of HIV by heterosexual men by between 38% and 66% over 24 months". Owing to these studies, both the World Health Organization and UNAIDS recommended male circumcision in 2007 as a method of preventing female-to-male HIV transmission in areas with high rates of HIV. However, whether it protects against male-to-female transmission
6864-487: The 20th mission for Discovery , it marked the first time a Space Shuttle mission had a female pilot, Eileen Collins , and the first EVAs for both a UK born astronaut, Michael Foale , and a US astronaut of African heritage, Bernard A. Harris, Jr. It also carried out the successful deployment and retrieval of the Spartan-204 platform, along with the scheduled rendezvous and flyaround of Mir , in preparation for STS-71 ,
7007-489: The CCR5 protein when present in both chromosomes very effectively prevents HIV-1 infection. HIV seeks out and destroys CCR5 expressing CD4 T cells during acute infection. A vigorous immune response eventually controls the infection and initiates the clinically latent phase. CD4 T cells in mucosal tissues remain particularly affected. Continuous HIV replication causes a state of generalized immune activation persisting throughout
7150-455: The Exploration and Use of Outer Space for Peaceful Purposes . This agreement called for setting up a short, joint space project, during which one American astronaut would board the Russian space station Mir and two Russian cosmonauts would board a Space Shuttle. In September 1993, American Vice-President Al Gore Jr. , and Russian Prime Minister Viktor Chernomyrdin announced plans for
7293-536: The International Space Station. Foale's Increment proceeded fairly normally until June 25, when a resupply ship collided with solar arrays on the Spektr module during the second test of the Progress manual docking system, TORU. The module's outer shell was hit and holed, which caused the station to lose pressure. This was the first on-orbit depressurization in the history of spaceflight. The crew quickly cut cables leading to
SECTION 50
#17328452650547436-424: The Shuttle. The objective of Astroculture was to validate performance of plant growth technologies in the microgravity environment of space for application to a life support system in space. The investigation had applications on Earth, since it covered such topics as energy-efficient lighting and removal of pollutants from indoor air. One of the pharmaceutical experiments, Immune, also had Earth applications. Exploiting
7579-634: The Station. The astronauts also received practice in carrying out spacewalks outside Mir and lessons in the Russian language , which would be used throughout their missions to talk with the other cosmonauts aboard the station and Mission Control in Russia, the TsUP . During their expeditions aboard Mir , the astronauts carried out various experiments, including growth of crops and crystals, and took hundreds of photographs of
7722-451: The United States that involved American Space Shuttles visiting the Russian space station Mir , Russian cosmonauts flying on the Shuttle, and an American astronaut flying aboard a Soyuz spacecraft to allow American astronauts to engage in long-duration expeditions aboard Mir . The project, sometimes called "Phase One", was intended to allow the United States to learn from Russian experience with long-duration spaceflight and to foster
7865-586: The University of Colorado, Boulder, developed the Fluids Generic Bioprocessing Apparatus-1 (FGBA-1) in cooperation with Coca-Cola and several other groups. It dispensed pre-mixed soda for astronauts' consumption and studied their changed taste perceptions. Astronauts rated control samples before and after flight. FGBA-2 flew on STS-77 . The six rays of the Sun and the three stars on the right of
8008-565: The absence of treatment will eventually progress to AIDS, a small proportion (about 5%) retain high levels of CD4 T cells ( T helper cells ) without antiretroviral therapy for more than five years. These individuals are classified as "HIV controllers" or long-term nonprogressors (LTNP). Another group consists of those who maintain a low or undetectable viral load without anti-retroviral treatment, known as "elite controllers" or "elite suppressors". They represent approximately 1 in 300 infected persons. Acquired immunodeficiency syndrome (AIDS)
8151-499: The absence of treatment, the risk of transmission before or during birth is around 20%, and in those who also breastfeed 35%. Treatment decreases this risk to less than 5%. Antiretrovirals when taken by either the mother or the baby decrease the risk of transmission in those who do breastfeed. If blood contaminates food during pre-chewing it may pose a risk of transmission. If a woman is untreated, two years of breastfeeding results in an HIV/AIDS risk in her baby of about 17%. Due to
8294-498: The acute phase of disease. HIV/AIDS is diagnosed via laboratory testing and then staged based on the presence of certain signs or symptoms . HIV screening is recommended by the United States Preventive Services Task Force for all people 15 years to 65 years of age, including all pregnant women. Additionally, testing is recommended for those at high risk, which includes anyone diagnosed with
8437-442: The capsule at a different location. This made Linenger the first American to undock from a space station aboard two different spacecraft (Space Shuttle and Soyuz). Linenger and his Russian crewmates Vasili Tsibliyev and Aleksandr Lazutkin faced several difficulties during the mission. These included the most severe fire aboard an orbiting spacecraft (caused by a backup oxygen-generating device), failures of various on board systems,
8580-406: The cell nucleus and integrated into the cellular DNA by a virally encoded integrase and host co-factors. Once integrated, the virus may become latent , allowing the virus and its host cell to avoid detection by the immune system. Alternatively, the virus may be transcribed , producing new RNA genomes and viral proteins that are packaged and released from the cell as new virus particles that begin
8723-425: The chronic phase. Immune activation, which is reflected by the increased activation state of immune cells and release of pro-inflammatory cytokines , results from the activity of several HIV gene products and the immune response to ongoing HIV replication. It is also linked to the breakdown of the immune surveillance system of the gastrointestinal mucosal barrier caused by the depletion of mucosal CD4 T cells during
SECTION 60
#17328452650548866-509: The condition of hardware and running cables through a special hatch from Spektr 's systems to the rest of the station. Following these first investigations, Foale and Solovyev conducted a 6-hour EVA on the surface of Spektr to inspect the damaged module. After these incidents, the US Congress and NASA considered whether to abandon the program out of concern for astronauts' safety but NASA administrator Daniel Goldin decided to continue
9009-513: The course of the flight, nearly 1,000 pounds (450 kg) of water were transferred to Mir and experiment samples including blood, urine and saliva were moved to Atlantis for return to Earth. Continuous US presence aboard Mir started in 1996 with the March 22 launch of Atlantis on mission STS-76 , when the Second Increment astronaut Shannon Lucid was transferred to the station. STS-76
9152-412: The crew lifted with the orbiter remote manipulator system arm SPARTAN-204 from its support structure in payload bay. SPARTAN remained suspended on the arm for observation of orbiter glow phenomenon and thruster jet firings. SPARTAN-204 was later released from the arm to complete about 40 hours of free-flight, during which time its Far Ultraviolet Imaging Spectrograph instrument studied celestial targets in
9295-404: The crew of Atlantis moved supplies to the station and returned to Earth the first plants to complete a life cycle in space; a crop of wheat planted by Shannon Lucid. During five days of mated operations, the crews transferred nearly 6,000 pounds (2,700 kg) of logistics to Mir , and transferred 2,400 pounds (1,100 kg) of materials back to Atlantis (the most materials transferred between
9438-542: The docking missions that followed. Five weeks after Discovery 's flight, the March 14 launch of Soyuz TM-21 carried expedition EO-18 to Mir . The crew consisted of cosmonauts Vladimir Dezhurov and Gennady Strekalov and NASA astronaut Norman Thagard , who became the first American to fly into space aboard the Soyuz spacecraft . During the course of their 115-day expedition, the Spektr science module (which served as living and working space for American astronauts)
9581-613: The early 1980s, HIV/AIDS has had a large impact on society, both as an illness and as a source of discrimination . The disease also has large economic impacts . There are many misconceptions about HIV/AIDS , such as the belief that it can be transmitted by casual non-sexual contact. The disease has become subject to many controversies involving religion , including the Catholic Church's position not to support condom use as prevention. It has attracted international medical and political attention as well as large-scale funding since it
9724-691: The early 1990s to begin a collaborative, multi-national, space station project. In the Russian Federation , as the successor to much of the Soviet Union and its space program, the deteriorating economic situation in the post-Soviet economic chaos led to growing financial problems of the now Russian space station program. The construction of the Mir-2 space station as a replacement for the aging Mir became illusionary, though only after its base block, DOS-8, had been built. These developments resulted in bringing
9867-458: The eight-day flight saw the first rendezvous of a Space Shuttle with Mir , as Russian cosmonaut Vladimir Titov and the rest of Discovery 's crew approached within 37 feet (11 m) of Mir . Following the rendezvous, Collins performed a flyaround of the station. The mission, a dress rehearsal for the first docked mission in the program, STS-71 , also carried out testing of various techniques and pieces of equipment that would be used during
10010-424: The end of this stage many people experience fever, weight loss, gastrointestinal problems and muscle pains. Between 50% and 70% of people also develop persistent generalized lymphadenopathy , characterized by unexplained, non-painful enlargement of more than one group of lymph nodes (other than in the groin) for over three to six months. Although most HIV-1 infected individuals have a detectable viral load and in
10153-716: The existence of the Soviet Intercosmos program. This changed after the Dissolution of the Soviet Union : the end of Cold War and Space Race resulted in funding for the US modular space station (originally named Freedom ), which was planned since the early 1980s, being slashed. Similar budgetary difficulties were being faced by other nations with space station projects, prompting American government officials to start negotiations with partners in Europe, Russia, Japan, and Canada in
10296-551: The expedition EO-18 crew. Atlantis also carried out on-orbit joint US-Russian life sciences investigations aboard a Spacelab module and performed a logistical resupply of the station. The final Shuttle flight of 1995, STS-74 , began with the November 12 launch of Space Shuttle Atlantis , and delivered the Russian-built Docking Module to Mir , along with a new pair of solar arrays and other hardware upgrades for
10439-410: The extreme cold of space. The two astronauts were then scheduled to practice handling the approximately 2,500 pound (1,100 kilograms (2,400 lb)) SPARTAN to rehearse space station assembly techniques, but both astronauts reported they were becoming very cold—this portion of the spacewalk being performed during a night pass—and mass handling was curtailed. This 29th Shuttle spacewalk, the first for both
10582-487: The final Shuttle– Mir mission, STS-91 . The mission closed out Phase One, with the EO-25 and STS-91 crews transferring water to Mir and exchanging almost 4,700 pounds (2,100 kg) of cargo experiments and supplies between the two spacecraft. Long-term American experiments that had been on board Mir were also moved into Discovery . Hatches were closed for undocking at 9:07 a.m. Eastern Daylight Time (EDT) on June 8 and
10725-435: The final outfitting of the station, completed in 2012. In 2015, a reconfiguration of the American segment was completed to allow its docking ports to accommodate NASA-sponsored commercial crew vehicles, that were expected to start visiting the ISS in 2018. As of June 2015 , the ISS has a pressurized volume of 915 cubic metres (32,300 cu ft), and its pressurized modules total 51 metres (167 ft) in length, plus
10868-471: The fire aboard the station and collision with the Progress supply vessel in 1997. The fire, caused by the malfunction of a backup solid-fuel oxygen generator (SFOG), burned for, according to various sources, between 90 seconds and 14 minutes, and produced large amounts of toxic smoke that filled the station for around 45 minutes. This forced the crew to don respirators, but some of the respirator masks initially worn were broken. Fire extinguishers mounted on
11011-465: The first 2.5 months of an HIV infection, a person's infectiousness is twelve times higher due to the high viral load associated with acute HIV. If the person is in the late stages of infection, rates of transmission are approximately eightfold greater. Commercial sex workers (including those in pornography ) have an increased likelihood of contracting HIV. Rough sex can be a factor associated with an increased risk of transmission. Sexual assault
11154-518: The first docking between an American Space Shuttle and the station. On June 29, Atlantis successfully docked with Mir , becoming the first US spacecraft to dock with a Russian spacecraft since the Apollo-Soyuz Test Project in 1975. Atlantis delivered cosmonauts Anatoly Solovyev and Nikolai Budarin , who would form the expedition EO-19 crew, and retrieved astronaut Norman Thagard and cosmonauts Vladimir Dezhurov and Gennady Strekalov of
11297-468: The first mission to dock with Mir . STS-63's primary objective was to perform a rendezvous and fly around the Russian space station Mir . The objectives of the Mir rendezvous were to verify flight techniques, communications and navigation aid sensor interfaces, and engineering analyses associated with Shuttle/ Mir proximity operations in preparation for the STS-71 docking mission. Other objectives of
11440-487: The first weeks of infection, especially in the intestinal mucosa, which harbors the majority of the lymphocytes found in the body. The reason for the preferential loss of mucosal CD4 T cells is that the majority of mucosal CD4 T cells express the CCR5 protein which HIV uses as a co-receptor to gain access to the cells, whereas only a small fraction of CD4 T cells in the bloodstream do so. A specific genetic change that alters
11583-531: The flight of Atlantis on STS-79 , which launched on September 16. STS-79 was the first Shuttle mission to carry a double Spacehab module. More than 4,000 pounds (1,800 kg) of supplies were transferred to Mir , including water generated by Atlantis 's fuel cells , and experiments that included investigations into superconductors , cartilage development, and other biology studies. About 2,000 pounds (910 kg) of experiment samples and equipment were also transferred back from Mir to Atlantis , making
11726-441: The flight of Space Shuttle Endeavour on STS-89 . The mission delivered cosmonaut Salizhan Sharipov to Mir and replaced David Wolf with Andy Thomas , following Wolf's 119-day Increment. During his Increment, the last of the program, Thomas worked on 27 science investigations into areas of advanced technology, Earth sciences , human life sciences, microgravity research, and ISS risk mitigation. His stay on Mir , considered
11869-586: The flight were to perform the operations necessary to fulfill the requirements of experiments located in SPACEHAB -3 and to fly captively, then deploy and retrieve the Spartan-204 payload. Spartan-204, the Shuttle Pointed Autonomous Research Tool for Astronomy, was a free-flying retrievable platform. It was designed to obtain data in the far ultraviolet region of the spectrum from diffuse sources of light. Two crewmembers were scheduled to perform
12012-635: The former adversaries together with the Shuttle– Mir Program, which would pave the way to the International Space Station , a joint project with several international partners. In June 1992, American President George H. W. Bush and Russian president Boris Yeltsin agreed to co-operate on space exploration by signing the Agreement between the United States of America and the Russian Federation Concerning Cooperation in
12155-517: The forward primary thruster, but the crew was able to fix the problem. After extensive negotiations and technical information exchanges between the U.S. and Russian space teams, the Russians concluded close approach could be safely achieved and the STS-63 crew was given 'go' to proceed. R1U's thruster manifold was closed and the backup thruster was selected for the approach. Ship-to-ship radio contact with Mir
12298-414: The health care environment are believed to be effective in decreasing the risk of HIV. Intravenous drug use is an important risk factor, and harm reduction strategies such as needle-exchange programs and opioid substitution therapy appear effective in decreasing this risk. A course of antiretrovirals administered within 48 to 72 hours after exposure to HIV-positive blood or genital secretions
12441-425: The human immune system such as CD4 T cells, macrophages and dendritic cells . It directly and indirectly destroys CD4 T cells. HIV is a member of the genus Lentivirus , part of the family Retroviridae . Lentiviruses share many morphological and biological characteristics. Many species of mammals are infected by lentiviruses, which are characteristically responsible for long-duration illnesses with
12584-400: The immune system. Which infections occur depends partly on what organisms are common in the person's environment. These infections may affect nearly every organ system . People with AIDS have an increased risk of developing various viral-induced cancers, including Kaposi's sarcoma , Burkitt's lymphoma , primary central nervous system lymphoma , and cervical cancer . Kaposi's sarcoma is
12727-407: The increased risk of death without breastfeeding in many areas in the developing world, the World Health Organization recommends either exclusive breastfeeding or the provision of safe formula. All women known to be HIV-positive should be taking lifelong antiretroviral therapy. HIV is the cause of the spectrum of disease known as HIV/AIDS. HIV is a retrovirus that primarily infects components of
12870-456: The infection in five groups. In those greater than six years of age it is: For surveillance purposes, the AIDS diagnosis still stands even if, after treatment, the CD4 T cell count rises to above 200 per μL of blood or other AIDS-defining illnesses are cured. Consistent condom use reduces the risk of HIV transmission by approximately 80% over the long term. When condoms are used consistently by
13013-497: The insignia symbolize the flight's numerical designation in the Space Transportation System's mission sequence. [REDACTED] This article incorporates public domain material from websites or documents of the National Aeronautics and Space Administration . Shuttle-Mir Program The Shuttle– Mir program ( Russian : Программа «Мир»–«Шаттл» ) was a collaborative space program between Russia and
13156-410: The interstellar medium, the gas and dust which fills the space between the stars and which is the material from which new stars and planets are formed. SPARTAN-204 was also used for extravehicular activity (EVA) near end of the flight. Foale and Harris began their EVA suspended at the end of the robot arm, away from the payload bay, to test modifications to their spacesuits to keep spacewalkers warmer in
13299-454: The launch of Chinese Tiangong-1 space laboratory on 29 September 2011. Mir 's legacy lives on in the station, bringing together five space agencies in the cause of exploration and allowing those space agencies to prepare for their next leap into space, to the Moon, Mars and beyond. Criticism of the program was primarily concerned with the safety of the aging Mir , particularly following
13442-528: The layer that lines the inner part of eyelids and the white part of the eye) is also more common in those with HIV. Additionally, people with AIDS frequently have systemic symptoms such as prolonged fevers, sweats (particularly at night), swollen lymph nodes, chills, weakness, and unintended weight loss . Diarrhea is another common symptom, present in about 90% of people with AIDS. They can also be affected by diverse psychiatric and neurological symptoms independent of opportunistic infections and cancers. HIV
13585-413: The likelihood of women with HIV using contraception, compared to basic services. It is not known whether treating other sexually transmitted infections is effective in preventing HIV. Antiretroviral treatment among people with HIV whose CD4 count ≤ 550 cells/μL is a very effective way to prevent HIV infection of their partner (a strategy known as treatment as prevention, or TASP). TASP is associated with
13728-400: The majority of their science aboard the station. These missions allowed NASA and Roscosmos to learn a great deal about how best to work with international partners in space and how to minimize the risks associated with assembling a large space station in orbit, as would have to be done with the ISS. The project also served as a political ruse on the part of the American government, providing
13871-539: The many common infectious diseases with similar symptoms. Someone with an unexplained fever who may have been recently exposed to HIV should consider testing to find out if they have been infected. The initial symptoms are followed by a stage called clinical latency, asymptomatic HIV, or chronic HIV. Without treatment, this second stage of the natural history of HIV infection can last from about three years to over 20 years (on average, about eight years). While typically there are few or no symptoms at first, near
14014-633: The mission was the Wake Shield Facility (or WSF), a device designed to generate new semiconductor films for advanced electronics. The WSF was flown at the end of Discovery 's robotic arm over the course of the flight. During the mission, the astronauts aboard Discovery also carried out various experiments aboard the Spacehab module in the Orbiter's payload bay, and took part in a live bi-directional audio and downlink video hookup between themselves and
14157-464: The module and closed Spektr 's hatch in order to prevent the need to abandon the station in their Soyuz lifeboat. Their efforts stabilized the station's air pressure, whilst the pressure in Spektr , containing many of Foale's experiments and personal effects, dropped to a vacuum. Fortunately, food, water and other vital supplies were stored in other modules, and salvage and replanning effort by Foale and
14300-437: The most common cancer, occurring in 10% to 20% of people with HIV. The second-most common cancer is lymphoma, which is the cause of death of nearly 16% of people with AIDS and is the initial sign of AIDS in 3% to 4%. Both these cancers are associated with human herpesvirus 8 (HHV-8). Cervical cancer occurs more frequently in those with AIDS because of its association with human papillomavirus (HPV). Conjunctival cancer (of
14443-608: The most common mode of HIV transmission is via sexual contacts between people of the opposite sex ; however, the pattern of transmission varies among countries. As of 2017 , most HIV transmission in the United States occurred among men who had sex with men (82% of new HIV diagnoses among males aged 13 and older and 70% of total new diagnoses). In the US, gay and bisexual men aged 13 to 24 accounted for an estimated 92% of new HIV diagnoses among all men in their age group and 27% of new diagnoses among all gay and bisexual men. With regard to unprotected heterosexual contacts, estimates of
14586-403: The orbital debris environment for objects smaller than 10 centimeters (about four inches) in diameter. A complement of six target objects of known dimensions and with limited orbital lifespans was released into orbit and tracked by ground-based radars, allowing precise calibration of radars so they can more accurately track smaller pieces of space debris in low Earth orbit. Also on flight day two,
14729-423: The orbiter away to 122 metres (400 ft) and performed a one and a quarter-loop flyaround of Mir while the station was filmed and photographed. The Mir crew reported no vibrations or solar array movement as result of the approach. The crew also worked extensively with payloads aboard Discovery . Flying in the forward payload bay and activated on flight day one was SPACEHAB-3. The commercially developed module
14872-462: The orbiter to approach to no closer than 10 meters (33 ft) from Mir , and then complete a flyaround of the Russian space station. However, three of the 44 orbiter Reaction Control System (RCS) thrusters—small firing jets used for on-orbit maneuvering—sprang leaks prior to rendezvous. Shortly after main engine cutoff, two leaks occurred in the aft primary thrusters, one of which—called R1U—was key to rendezvous. A third leak occurred later in flight in
15015-549: The orbiter, Discovery was flown to 11 metres (36 ft) from the Russian space station. "As we are bringing our spaceships closer together, we are bringing our nations closer together," Wetherbee said after Discovery was at point of closest approach. "The next time we approach, we will shake your hand and together we will lead our world into the next millennium." The closest approach to Mir of 11 metres (36 ft) occurred on February 6, 1995, at 19:23:20 UTC. "We are one. We are human," Viktorenko responded. Wetherbee then backed
15158-468: The pair affixed a 121-pound (55 kg) Solar Array Cap to the Docking Module , for a future attempt by crew members to seal off the leak in Spektr 's hull. The mission returned Foale to Earth, along with samples, hardware, and an old Elektron oxygen generator, and dropped Wolf off on the Station ready for his 128-day Increment. Wolf had originally been scheduled to be the final Mir astronaut, but
15301-453: The presence of many sexually transmitted infections and genital ulcers . Genital ulcers increase the risk approximately fivefold. Other sexually transmitted infections, such as gonorrhea , chlamydia , trichomoniasis , and bacterial vaginosis , are associated with somewhat smaller increases in risk of transmission. The viral load of an infected person is an important risk factor in both sexual and mother-to-child transmission. During
15444-416: The program. The next flight to Mir , STS-86 , brought Increment astronaut David Wolf to the station. STS-86 performed the seventh Shuttle– Mir docking, the last of 1997. During Atlantis 's stay crew members Titov and Parazynski conducted the first joint US–Russian extravehicular activity during a Shuttle mission, and the first in which a Russian wore a US spacesuit. During the five-hour spacewalk,
15587-405: The project continued until its scheduled completion in 1998. Eleven Space Shuttle missions, a joint Soyuz flight and almost 1,000 cumulative days in space for American astronauts occurred over the course of seven long-duration expeditions. In addition to Space Shuttle launches to Mir the United States also fully funded and equipped with scientific equipment the Spektr module (launched in 1995) and
15730-434: The replication cycle anew. HIV is now known to spread between CD4 T cells by two parallel routes: cell-free spread and cell-to-cell spread, i.e. it employs hybrid spreading mechanisms. In the cell-free spread, virus particles bud from an infected T cell, enter the blood/extracellular fluid and then infect another T cell following a chance encounter. HIV can also disseminate by direct transmission from one cell to another by
15873-487: The risk of HIV transmission per sexual act appear to be four to ten times higher in low-income countries than in high-income countries. In low-income countries, the risk of female-to-male transmission is estimated as 0.38% per act, and of male-to-female transmission as 0.30% per act; the equivalent estimates for high-income countries are 0.04% per act for female-to-male transmission, and 0.08% per act for male-to-female transmission. The risk of transmission from anal intercourse
16016-426: The science community minimized the loss of research data and capability. In an effort to restore some of the power and systems lost following the isolation of Spektr and to attempt to locate the leak, Mir 's new commander Anatoly Solovyev and flight engineer Pavel Vinogradov carried out a salvage operation later in the mission. They entered the empty module during a so-called "IVA" spacewalk, inspecting
16159-524: The smoothest of the entire Phase One program, featured weekly "Letters from the Outpost" from Thomas and passed two milestones for length of spaceflight—815 consecutive days in space by American astronauts since the launch of Shannon Lucid on the STS-76 mission in March 1996, and 907 days of Mir occupancy by American astronauts dating back to Norman Thagard's trip to Mir in March 1995. Thomas returned to Earth on
16302-532: The spacecraft separated at 12:01 p.m. EDT that day. With the landing of Discovery on June 12, 1998, the Phase One program concluded. Techniques and equipment developed during the program assisted the development of Phase Two: initial assembly of the International Space Station (ISS). The arrival of the Destiny Laboratory Module in 2001 marked the end of Phase Two and the start of Phase Three,
16445-469: The station, long-duration flights aboard Mir by American astronauts. The seven astronauts who took part in the Increments, Norman Thagard , Shannon Lucid , John Blaha , Jerry Linenger , Michael Foale , David Wolf and Andrew Thomas , were each flown in turn to Star City , Russia , to undergo training in various aspects of the operation of Mir and the Soyuz spacecraft used for transport to and from
16588-529: The station. During his Increment, Linenger became the first American to conduct a spacewalk from a foreign space station and the first to test the Russian-built Orlan-M spacesuit alongside Russian cosmonaut Vasili Tsibliyev . All three crewmembers of expedition EO-23 performed a "fly-around" in the Soyuz spacecraft, first undocking from one docking port of the station, then manually flying to and redocking
16731-427: The station. The Docking Module was designed to provide more clearance for Shuttles in order to prevent any collisions with Mir 's solar arrays during docking, a problem which had been overcome during STS-71 by relocating the station's Kristall module to a different location on the station. The module, attached to Kristall 's docking port, prevented the need for this procedure on further missions. During
16874-402: The telemetry system to allow the experiment investigator to link directly via computer with the onboard experiment to receive data and monitor status. Charlotte, an experimental robotic device being flown for the first time, also reduced crew workload by taking over simple tasks such as changing experiment samples. Among the plant growth experiments was Astroculture, flying for the fourth time on
17017-480: The three cosmonauts on board Mir , Valeri Polyakov , Viktor Afanasyev and Yury Usachev (flying Mir expeditions LD-4 and EO-15). 1995 began with the launch of the Space Shuttle Discovery on February 3. Discovery's mission, STS-63 , was the second Space Shuttle flight in the program and the first flight of the shuttle with a female pilot, Eileen Collins . Referred to as the "near- Mir " mission,
17160-461: The total transfer the most extensive yet. This, the fourth docking, also saw John Blaha transferring onto Mir to take his place as resident Increment astronaut. His stay on the station improved operations in several areas, including transfer procedures for a docked space shuttle, "hand-over" procedures for long-duration American crew members and "Ham" amateur radio communications. Two spacewalks were carried out during his time aboard. Their aim
17303-480: The trunk and is maculopapular , classically. Some people also develop opportunistic infections at this stage. Gastrointestinal symptoms, such as vomiting or diarrhea may occur. Neurological symptoms of peripheral neuropathy or Guillain–Barré syndrome also occur. The duration of the symptoms varies, but is usually one or two weeks. These symptoms are not often recognized as signs of HIV infection. Family doctors or hospitals can misdiagnose cases as one of
17446-565: The two spacecraft to that date). The STS-81 crew also tested the Shuttle Treadmill Vibration Isolation and Stabilization System (TVIS), designed for use in the Zvezda module of the International Space Station. The shuttle's small vernier jet thrusters were fired during the mated operations to gather engineering data for "reboosting" the ISS. After undocking, Atlantis performed a fly-around of Mir , leaving Linenger aboard
17589-399: The two spacecraft, along with water, experiment samples, supplies and hardware. One of the first items transferred to Mir was an Elektron oxygen-generating unit. Atlantis was stopped three times while backing away during the undocking sequence on May 21. The aim was to collect data from a European sensor device designed for future rendezvous of ESA 's Automated Transfer Vehicle (ATV) with
17732-552: The two systems allow a comparison for statistical purposes. The World Health Organization first proposed a definition for AIDS in 1986. Since then, the WHO classification has been updated and expanded several times, with the most recent version being published in 2007. The WHO system uses the following categories: The U.S. Centers for Disease Control and Prevention also created a classification system for HIV, and updated it in 2008 and 2014. This system classifies HIV infections based on CD4 count and clinical symptoms, and describes
17875-502: The virus. Ultimately, HIV causes AIDS by depleting CD4 T cells. This weakens the immune system and allows opportunistic infections . T cells are essential to the immune response and without them, the body cannot fight infections or kill cancerous cells. The mechanism of CD4 T cell depletion differs in the acute and chronic phases. During the acute phase, HIV-induced cell lysis and killing of infected cells by CD8 T cells accounts for CD4 T cell depletion, although apoptosis may also be
18018-463: The virus. Oral sex has little risk of transmitting the virus. Ways to avoid catching HIV and preventing the spread include safe sex , treatment to prevent infection (" PrEP "), treatment to stop infection in someone who has been recently exposed (" PEP "), treating those who are infected , and needle exchange programs . Disease in a baby can often be prevented by giving both the mother and child antiretroviral medication . Recognized worldwide in
18161-537: The walls of the modules were immovable. The fire occurred during a crew rotation, and as such there were six men aboard the station rather than the usual three. Access to one of the docked Soyuz lifeboats was blocked, which would have prevented escape by half of the crew. A similar incident had occurred on an earlier Mir expedition, although in that case the SFOG burned for only a few seconds. Acquired immunodeficiency syndrome The human immunodeficiency virus ( HIV )
18304-559: The world lacks access to reliable PCR testing, and people in many places simply wait until either symptoms develop or the child is old enough for accurate antibody testing. In sub-Saharan Africa between 2007 and 2009, between 30% and 70% of the population were aware of their HIV status. In 2009, between 3.6% and 42% of men and women in sub-Saharan countries were tested; this represented a significant increase compared to previous years. Two main clinical staging systems are used to classify HIV and HIV-related disease for surveillance purposes:
18447-482: The world. People giving or receiving tattoos , piercings , and scarification are theoretically at risk of infection but no confirmed cases have been documented. It is not possible for mosquitoes or other insects to transmit HIV. HIV can be transmitted from mother to child during pregnancy, during delivery, or through breast milk, resulting in the baby also contracting HIV. As of 2008, vertical transmission accounted for about 90% of cases of HIV in children. In
18590-435: Was Space Transportation System (STS) , taken from a 1969 plan for a system of reusable spacecraft of which it was the only item funded for development. The first of four orbital test flights occurred in 1981, leading to operational flights beginning in 1982. In addition to the prototype, whose completion was cancelled, five complete Shuttle systems were built and used on a total of 135 missions from 1981 to 2011, launched from
18733-458: Was achieved well ahead of time, and Titov, who had previously lived on Mir for more than a year, communicated excitedly with the three cosmonauts aboard the space station: Mir 17 Commander Alexander Viktorenko ; Flight Engineer Yelena Kondakova ; and Valery Polyakov , a physician who had broken Titov's record for extended time in space. After stationkeeping at a distance of 122 metres (400 ft) from Mir and with Wetherbee manually controlling
18876-549: Was anticipated to visit Mir , but its program was canceled after its first uncrewed spaceflight. Visiting US Space Shuttles used an Androgynous Peripheral Attach System docking collar originally designed for Buran, mounted on a bracket originally designed for use with the American Space Station Freedom . With the Space Shuttle docked to Mir , the temporary enlargements of living and working areas amounted to
19019-472: Was chosen to go on the Increment instead of astronaut Wendy Lawrence . Lawrence was deemed ineligible for flight because of a change in Russian requirements after the Progress supply vehicle collision. The new rules required that all Mir crew members should be trained and ready for spacewalks, but a Russian spacesuit could not be prepared for Lawrence in time for launch. The final year of Phase One began with
19162-453: Was constructed between 1986 and 1996 and was the world's first modular space station. It was the first consistently inhabited long-term research station in space, and previously held the record for longest continuous human presence in space, at eight days short of ten years. Mir 's purpose was to provide a large and habitable scientific laboratory in space, and, through a number of collaborations, including Intercosmos and Shuttle– Mir ,
19305-537: Was followed during the course of the project by nine Shuttle– Mir docking missions, from STS-71 to STS-91 . The Shuttle rotated crews and delivered supplies, and one mission, STS-74 , carried a docking module and a pair of solar arrays to Mir . Various scientific experiments were also conducted, both on shuttle flights and long-term aboard the station. The project also saw the launch of two new modules, Spektr and Priroda , to Mir , which were used by American astronauts as living quarters and laboratories to conduct
19448-634: Was identified in the 1980s. HIV made the jump from other primates to humans in west-central Africa in the early-to-mid-20th century. AIDS was first recognized by the U.S. Centers for Disease Control and Prevention (CDC) in 1981 and its cause—HIV infection—was identified in the early part of the decade. Between the first time AIDS was readily identified through 2024, the disease is estimated to have caused at least 42.3 million deaths worldwide. In 2023, 630,000 people died from HIV-related causes, an estimated 1.3 million people acquired HIV and about 39.9 million people worldwide living with HIV, 65% of whom are in
19591-496: Was launched aboard a Proton rocket and docked to Mir . Spektr carried more than 1,500 pounds (680 kg) of research equipment from America and other nations. The expedition's crew returned to Earth aboard Space Shuttle Atlantis following the first Shuttle– Mir docking during mission STS-71 . The primary objectives of STS-71, launched on June 27, called for the Space Shuttle Atlantis to rendezvous and perform
19734-553: Was made internationally accessible to cosmonauts and astronauts of many different countries. The station existed until March 23, 2001, at which point it was deliberately deorbited, and broke apart during atmospheric re-entry. Mir was based upon the Salyut series of space stations previously launched by the Soviet Union (seven Salyut space stations had been launched since 1971), and was mainly serviced by Russian-crewed Soyuz spacecraft and Progress cargo ships. The Buran space shuttle
19877-531: Was making its third flight on the Shuttle and carried 20 experiments: 11 biotechnology experiments, three advanced materials development experiments, four technology demonstrations and two pieces of supporting hardware measuring on-orbit accelerations. Improvements had been made to the SPACEHAB system to reduce demand on crew time. A new video switch had been added to lessen the need for astronaut involvement in video operations, and an experiment interface had been added to
20020-526: Was the first shuttle flight of that year, the first flight of a Russian cosmonaut , Sergei Krikalev , aboard the American shuttle, and marked the start of increased cooperation in space for the two nations, 37 years after the Space Race began. Part of an international agreement on human space flight, the mission was the second flight of the Spacehab pressurized module and marked the hundredth " Getaway Special " payload to fly in space. The primary payload for
20163-507: Was the oldest and heaviest of the fleet, it was not suited for efficient operations at Mir 's (and later the ISS's ) 51.6-degree inclination – Columbia was therefore not retrofitted with the necessary external airlock and Orbital Docking System, and never flew to a space station. Phase One of the Shuttle– Mir program began on February 3, 1994, with the launch of Space Shuttle Discovery on its 18th mission, STS-60 . The eight-day mission
20306-430: Was the third docking mission to Mir , which also demonstrated logistics capabilities through deployment of a Spacehab module, and placed experiment packages aboard Mir 's docking module, which marked the first spacewalk which occurred around docked vehicles. The spacewalks, carried out from Atlantis 's crew cabin, provided valuable experience for astronauts in order to prepare for later assembly missions to
20449-591: Was to remove electrical power connectors from a 12-year-old solar power array on the base block and reconnect the cables to the more efficient new solar power arrays. In all, Blaha spent four months with the Mir-22 cosmonaut crew conducting material science , fluid science , and life science research, before returning to Earth the next year aboard Atlantis on STS-81 . In 1997 STS-81 replaced Increment astronaut John Blaha with Jerry Linenger , after Blaha's 118-day stay aboard Mir . During this fifth shuttle docking,
#53946