The International HapMap Project was an organization that aimed to develop a haplotype map ( HapMap ) of the human genome , to describe the common patterns of human genetic variation . HapMap is used to find genetic variants affecting health, disease and responses to drugs and environmental factors. The information produced by the project is made freely available for research.
136-557: The International HapMap Project is a collaboration among researchers at academic centers, non-profit biomedical research groups and private companies in Canada , China (including Hong Kong ), Japan , Nigeria , the United Kingdom , and the United States . It officially started with a meeting on October 27 to 29, 2002, and was expected to take about three years. It comprises three phases;
272-451: A high nominal per capita income globally and its advanced economy ranks among the largest in the world by nominal GDP , relying chiefly upon its abundant natural resources and well-developed international trade networks . Recognized as a middle power , Canada's strong support for multilateralism and internationalism has been closely related to its foreign relations policies of peacekeeping and aid for developing countries . Canada
408-467: A parliamentary system within the context of a constitutional monarchy —the monarchy of Canada being the foundation of the executive, legislative , and judicial branches. The reigning monarch is also monarch of 14 other sovereign Commonwealth countries and Canada's 10 provinces . The monarch appoints a representative, the governor general , on the advice of the prime minister , to carry out most of their ceremonial royal duties. The monarchy
544-646: A 10-metre (33 ft) cross bearing the words, "long live the King of France", and took possession of the territory New France in the name of King Francis I . The early 16th century saw European mariners with navigational techniques pioneered by the Basque and Portuguese establish seasonal whaling and fishing outposts along the Atlantic coast. In general, early settlements during the Age of Discovery appear to have been short-lived due to
680-625: A combination of the harsh climate, problems with navigating trade routes and competing outputs in Scandinavia. In 1583, Sir Humphrey Gilbert , by the royal prerogative of Queen Elizabeth I , founded St John's, Newfoundland , as the first North American English seasonal camp . In 1600, the French established their first seasonal trading post at Tadoussac along the Saint Lawrence. French explorer Samuel de Champlain arrived in 1603 and established
816-554: A constitutional amending formula and the Canadian Charter of Rights and Freedoms . The Charter guarantees basic rights and freedoms that usually cannot be overridden by any government; a notwithstanding clause allows Parliament and the provincial legislatures to override certain sections of the Charter for a period of five years. Canada's judiciary interprets laws and has the power to strike down acts of Parliament that violate
952-557: A description of Greece itself, besides accounts of western and northern Europe. His work survives only fragmentarily, but was received by Polybius and others. Roman Empire period authors include Diodorus Siculus , Strabo and Tacitus . Julius Caesar gives an account of the Celtic tribes of Gaul , while Tacitus describes the Germanic tribes of Magna Germania . A number of authors like Diodorus Siculus, Pausanias and Sallust depict
1088-506: A distinguishing element of Canada's political culture. Peace, order, and good government , alongside an Implied Bill of Rights , are founding principles of Canadian federalism . At the federal level, Canada has been dominated by two relatively centrist parties practising "brokerage politics": the centre-left leaning Liberal Party of Canada and the centre-right leaning Conservative Party of Canada (or its predecessors ). The historically predominant Liberals position themselves at
1224-665: A given region of interest is also provided. These data can also be directly accessed from the widely used Haploview program. Canada Canada is a country in North America . Its ten provinces and three territories extend from the Atlantic Ocean to the Pacific Ocean and northward into the Arctic Ocean , making it the world's second-largest country by total area , with the world's longest coastline . Its border with
1360-489: A large re-sequencing project to discover millions of additional SNPs. These were submitted to the public dbSNP database. As a result, by August 2006, the database included more than ten million SNPs, and more than 40% of them were known to be polymorphic . By comparison, at the start of the project, fewer than 3 million SNPs were identified, and no more than 10% of them were known to be polymorphic. During Phase II, more than two million additional SNPs were genotyped throughout
1496-684: A long history in Europe , but is a small minority religion, with France (1%) the only European country with a Jewish population in excess of 0.5%. The Jewish population of Europe is composed primarily of two groups , the Ashkenazi and the Sephardi . Ancestors of Ashkenazi Jews likely migrated to Central Europe at least as early as the 8th century , while Sephardi Jews established themselves in Spain and Portugal at least one thousand years before that. Jews originated in
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#17328516507531632-508: A mixture of four distinct ancestral components. Iron Age (pre- Great Migrations ) populations of Europe known from Greco-Roman historiography , notably Herodotus , Pliny , Ptolemy and Tacitus : Ethno-linguistic groups that arrived from outside Europe during historical times are: The earliest accounts of European ethnography date from Classical Antiquity . Herodotus described the Scythians and Thraco-Illyrians . Dicaearchus gave
1768-448: A relation of the peoples of Europe are expressed in terms of genealogy of mythical founders of the individual groups. The Europeans were considered the descendants of Japheth from early times, corresponding to the division of the known world into three continents , the descendants of Shem peopling Asia and those of Ham peopling Africa . Identification of Europeans as " Japhetites " is also reflected in early suggestions for terming
1904-455: A shortcut. Although any two unrelated people share about 99.5% of their DNA sequence, their genomes differ at specific nucleotide locations. Such sites are known as single nucleotide polymorphisms (SNPs), and each of the possible resulting gene forms is called an allele . The HapMap project focuses only on common SNPs, those where each allele occurs in at least 1% of the population. Each person has two copies of all chromosomes , except
2040-766: A team led by David Altshuler and Mark Daly at the Broad Institute in Cambridge, USA (chromosomes 4q, 7q, 18p, Y and mitochondrion ), a team led by Richard Gibbs at the Baylor College of Medicine in Houston (chromosome 12), and a team led by Pui-Yan Kwok at the University of California, San Francisco (chromosome 7p). To obtain enough SNPs to create the Map, the Consortium funded
2176-431: A temperate climate, with a mild and rainy winter. On the east and west coasts, average high temperatures are generally in the low 20s °C (70s °F), while between the coasts, the average summer high temperature ranges from 25 to 30 °C (77 to 86 °F), with temperatures in some interior locations occasionally exceeding 40 °C (104 °F). Much of Northern Canada is covered by ice and permafrost . The future of
2312-515: Is a better model of UK British individuals than is CEU alone. It was expensive in the 1990s to sequence patients’ whole genomes. So the National Institutes of Health embraced the idea for a "shortcut", which was to look just at sites on the genome where many people have a variant DNA unit. The theory behind the shortcut was that, since the major diseases are common, so too would be the genetic variants that caused them. Natural selection keeps
2448-554: Is divided into 15 terrestrial and five marine ecozones . These ecozones encompass over 80,000 classified species of Canadian wildlife , with an equal number yet to be formally recognized or discovered. Although Canada has a low percentage of endemic species compared to other countries , due to human activities, invasive species , and environmental issues in the country , there are currently more than 800 species at risk of being lost . About 65 percent of Canada's resident species are considered "Secure". Over half of Canada's landscape
2584-501: Is estimated at 105 million people, or 14% of 770 million Europeans in 2002. The Russians are the most populous among Europeans, with a population of roughly 120 million. There are no universally accepted and precise definitions of the terms " ethnic group " and " nationality ". In the context of European ethnography in particular, the terms ethnic group , people , nationality and ethno-linguistic group are used as mostly synonymous, although preference may vary in usage with respect to
2720-503: Is generally linked to the classical definition of the Western world . In this definition, Western culture is the set of literary , scientific , political , artistic and philosophical principles which set it apart from other civilizations. Much of this set of traditions and knowledge is collected in the Western canon . The term has come to apply to countries whose history has been strongly marked by European immigration or settlement during
2856-1019: Is intact and relatively free of human development. The boreal forest of Canada is considered to be the largest intact forest on Earth, with approximately 3,000,000 km (1,200,000 sq mi) undisturbed by roads, cities or industry. Since the end of the last glacial period , Canada has consisted of eight distinct forest regions . Approximately 12.1 percent of the nation's landmass and freshwater are conservation areas , including 11.4 percent designated as protected areas . Approximately 13.8 percent of its territorial waters are conserved, including 8.9 percent designated as protected areas. Canada's first National Park , Banff National Park established in 1885 spans 6,641 square kilometres (2,564 sq mi). Canada's oldest provincial park, Algonquin Provincial Park , established in 1893, covers an area of 7,653.45 square kilometres (2,955.01 sq mi). Lake Superior National Marine Conservation Area
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#17328516507532992-552: Is now Canada for thousands of years. Beginning in the 16th century, British and French expeditions explored and later settled along the Atlantic coast. As a consequence of various armed conflicts , France ceded nearly all of its colonies in North America in 1763. In 1867, with the union of three British North American colonies through Confederation , Canada was formed as a federal dominion of four provinces. This began an accretion of provinces and territories resulting in
3128-454: Is part of multiple international organizations and forums . While a variety of theories have been postulated for the etymological origins of Canada , the name is now accepted as coming from the St. Lawrence Iroquoian word kanata , meaning "village" or "settlement". In 1535, Indigenous inhabitants of the present-day Quebec City region used the word to direct French explorer Jacques Cartier to
3264-683: Is solely a federal responsibility and is uniform throughout Canada. Law enforcement, including criminal courts, is officially a provincial responsibility, conducted by provincial and municipal police forces. In most rural and some urban areas, policing responsibilities are contracted to the federal Royal Canadian Mounted Police . Canadian Aboriginal law provides certain constitutionally recognized rights to land and traditional practices for Indigenous groups in Canada. Various treaties and case laws were established to mediate relations between Europeans and many Indigenous peoples. The role of Aboriginal law and
3400-399: Is the second-largest country . By land area alone, Canada ranks fourth , due to having the world's largest area of fresh water lakes . Stretching from the Atlantic Ocean in the east, along the Arctic Ocean to the north, and to the Pacific Ocean in the west, the country encompasses 9,984,670 km (3,855,100 sq mi) of territory. Canada also has vast maritime terrain, with
3536-547: Is the largest Christian country in Europe by population, followed by Germany and Italy . According to Scholars, in 2017, Europe's population was 77.8% Christian (up from 74.9% 1970), these changes were largely result of the collapse of Communism and switching to Christianity in the former Soviet Union and Eastern Bloc countries. Islam has some tradition in the Balkans and the Caucasus due to conquest and colonization from
3672-657: Is the largest religion in the European Union , accounting for 72% of the EU 's population. As of 2010 Catholics were the largest Christian group in Europe , accounting for more than 48% of European Christians. The second-largest Christian group in Europe were the Orthodox , who made up 32% of European Christians. About 19% of European Christians were part of the Protestant tradition. Russia
3808-423: Is the so-called "time element", or how long the original inhabitants of a land occupied it before the arrival of later settlers. As there is no fixed time frame, the answer to the question of what groups constitute Indigenous minorities is often context-dependent. The most extreme view claims that all Europeans are "descendants of previous waves of immigrants", and as such, the countries of Europe are no different from
3944-512: Is the source of sovereignty and authority in Canada. However, while the governor general or monarch may exercise their power without ministerial advice in rare crisis situations , the use of the executive powers (or royal prerogative ) is otherwise directed by the Cabinet , a committee of ministers of the Crown responsible to the elected House of Commons and chosen and headed by the prime minister,
4080-545: Is the world's largest freshwater protected area, spanning roughly 10,000 square kilometres (3,900 sq mi). Canada's largest national wildlife region is the Scott Islands Marine National Wildlife Area which spans 11,570.65 square kilometres (4,467.45 sq mi). Canada is described as a " full democracy ", with a tradition of liberalism , and an egalitarian , moderate political ideology. An emphasis on social justice has been
4216-754: Is very heterogeneous, with more than 95% in Poland, and less than 20% in the Czech Republic and Estonia. The 2005 Eurobarometer poll found that 52% of EU citizens believe in God. According to a Pew Research Center Survey in 2012 the Religiously Unaffiliated ( Atheists and Agnostics ) make up about 18.2% of the European population in 2010. According to the same Survey the Religiously Unaffiliated make up
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4352-644: The Canada Elections Act limits this to four years with a "fixed" election date in October; general elections still must be called by the governor general and can be triggered by either the advice of the prime minister or a lost confidence vote in the House. The 105 members of the Senate, whose seats are apportioned on a regional basis, serve until age 75. Canadian federalism divides government responsibilities between
4488-672: The Dominion Lands Act to regulate settlement and established the North-West Mounted Police to assert authority over the territory. This period of westward expansion and nation building resulted in the displacement of many Indigenous peoples of the Canadian Prairies to " Indian reserves ", clearing the way for ethnic European block settlements . This caused the collapse of the Plains Bison in western Canada and
4624-746: The Battle of the Scheldt in 1944. Canada provided asylum for the Dutch monarchy while that country was occupied and is credited by the Netherlands for major contributions to its liberation from Nazi Germany . The Canadian economy boomed during the war as its industries manufactured military materiel for Canada, Britain, China , and the Soviet Union . Despite another Conscription Crisis in Quebec in 1944, Canada finished
4760-520: The Bell beaker period), and a Proto-Balto-Slavic language (assumed for roughly the Corded Ware horizon) has been postulated with less confidence. Old European hydronymy has been taken as indicating an early (Bronze Age) Indo-European predecessor of the later centum languages. According to geneticist David Reich , based on ancient human genomes that his laboratory sequenced in 2016, Europeans descend from
4896-602: The COVID-19 pandemic in Canada began on January 27, 2020, with widespread social and economic disruption. In 2021, the possible graves of hundreds of Indigenous people were discovered near the former sites of Canadian Indian residential schools . Administered by various Christian churches and funded by the Canadian government from 1828 to 1997, these boarding schools attempted to assimilate Indigenous children into Euro-Canadian culture . By total area (including its waters), Canada
5032-628: The Canada Act 1982 , the patriation of Canada's constitution from the United Kingdom, concurrent with the creation of the Canadian Charter of Rights and Freedoms . Canada had established complete sovereignty as an independent country under its own monarchy . In 1999, Nunavut became Canada's third territory after a series of negotiations with the federal government. At the same time, Quebec underwent profound social and economic changes through
5168-783: The Canadian Shield , the interior plains , the Great Lakes-St. Lawrence Lowlands , the Appalachian region , the Western Cordillera , Hudson Bay Lowlands , and the Arctic Archipelago . Boreal forests prevail throughout the country, ice is prominent in northern Arctic regions and through the Rocky Mountains , and the relatively flat Canadian Prairies in the southwest facilitate productive agriculture. The Great Lakes feed
5304-556: The Cold War , since the 1990s. The foundation of the OSCE following the 1990s Paris Charter has facilitated this process on a political level during the 1990s and 2000s. From the later 20th century, 'Europe' has come to be widely used as a synonym for the European Union even though there are millions of people living on the European continent in non-EU member states. The prefix pan implies that
5440-536: The Framework Convention for the Protection of National Minorities . The broad aims of the convention are to ensure that the signatory states respect the rights of national minorities, undertaking to combat discrimination, promote equality, preserve and develop the culture and identity of national minorities, guarantee certain freedoms in relation to access to the media, minority languages and education and encourage
5576-623: The Indo-European languages of Europe, including: Besides the Indo-European languages, there are other language families on the European continent which are considered unrelated to Indo-European: The Basques have been found to descend from the population of the late Neolithic or early Bronze Age directly. By contrast, Indo-European groups of Europe (the Centum , Balto-Slavic , and Albanian groups) migrated throughout most of Europe from
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5712-569: The Indo-European languages "Japhetic". In this tradition, the Historia Brittonum (9th century) introduces a genealogy of the peoples of the Migration Period based on the sixth-century Frankish Table of Nations as follows, The text goes then on to list the genealogy of Alanus, connecting him to Japheth via eighteen generations. European culture is largely rooted in what is often referred to as its "common cultural heritage". Due to
5848-697: The Levant where they resided for thousands of years until the 2nd century AD, when they spread around the Mediterranean and into Europe, although small communities were known to exist in Greece as well as the Balkans since at least the 1st century BC. Jewish history was notably affected by the Holocaust and emigration (including Aliyah , as well as emigration to America ) in the 20th century. The Jewish population of Europe in 2010
5984-731: The Meech Lake Accord failed in 1990. This led to the formation of the Bloc Québécois in Quebec and the invigoration of the Reform Party of Canada in the West. A second referendum followed in 1995, in which sovereignty was rejected by a slimmer margin of 50.6 to 49.4 percent. In 1997, the Supreme Court ruled unilateral secession by a province would be unconstitutional, and the Clarity Act
6120-413: The Oka Crisis of 1990, the first of a number of violent confrontations between provincial governments and Indigenous groups. Canada joined the Gulf War in 1990 and was active in several peacekeeping missions in the 1990s, including operations in the Balkans during and after the Yugoslav Wars , and in Somalia , resulting in an incident that has been described as " the darkest era in the history of
6256-448: The Oriental Church , is also in Europe – another branch of Christianity (world's oldest National Church). Catholicism , while typically centered in Western Europe , also has a very significant following in Central Europe (especially among the Germanic , Western Slavic and Hungarian peoples/regions) as well as in Ireland (with some in Great Britain). Christianity has been the dominant religion shaping European culture for at least
6392-450: The Ottoman Empire in the 16th to 19th centuries, as well as earlier though discontinued long-term presence in much of Iberia as well as Sicily . Muslims account for the majority of the populations in Albania , Azerbaijan , Kosovo , Northern Cyprus (controlled by Turks ), and Bosnia and Herzegovina . Significant minorities are present in the rest of Europe. Russia also has one of the largest Muslim communities in Europe, including
6528-446: The Parliament of Canada and the commissioners represent the King in his federal Council , rather than the monarch directly. The powers flowing from the Constitution Act, 1867 , are divided between the federal government and the provincial governments to exercise exclusively and any changes to that arrangement require a constitutional amendment , while changes to the roles and powers of the territories may be performed unilaterally by
6664-553: The Pontic steppe . They are assumed to have developed in situ through admixture of earlier Mesolithic and Neolithic populations with Bronze Age, proto-Indo-Europeans . The Finnic peoples are assumed to also be descended from Proto-Uralic populations further to the east, nearer to the Ural Mountains , that had migrated to their historical homelands in Europe by about 3,000 years ago. Reconstructed languages of Iron Age Europe include Proto-Celtic , Proto-Italic and Proto-Germanic , all of these Indo-European languages of
6800-425: The Quiet Revolution of the 1960s, giving birth to a secular nationalist movement. The radical Front de libération du Québec (FLQ) ignited the October Crisis with a series of bombings and kidnappings in 1970, and the sovereigntist Parti Québécois was elected in 1976, organizing an unsuccessful referendum on sovereignty-association in 1980. Attempts to accommodate Quebec nationalism constitutionally through
6936-449: The Scottish Highlands , and the Isle of Man ; Also the Silesian and Sorbian people of Germany and Poland. Many non-European ethnic groups and nationalities have migrated to Europe over the centuries. Some arrived centuries ago. However, the vast majority arrived more recently, mostly in the 20th and 21st centuries. Often, they come from former colonies of the British, Dutch, French, Portuguese and Spanish empires. Medieval notions of
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#17328516507537072-584: The St. Lawrence River (in the southeast) where the lowlands host much of Canada's economic output. Canada has over 2,000,000 lakes—563 of which are larger than 100 km (39 sq mi)—containing much of the world's fresh water . There are also fresh-water glaciers in the Canadian Rockies , the Coast Mountains , and the Arctic Cordillera . Canada is geologically active , having many earthquakes and potentially active volcanoes . Average winter and summer high temperatures across Canada vary from region to region. Winters can be harsh in many parts of
7208-462: The Swiss are discussed in terms of both ethnicity and language affiliations. Of the total population of Europe of some 740 million (as of 2010), close to 90% (or some 650 million) fall within three large branches of Indo-European languages , these being: Three stand-alone Indo-European languages do not fall within larger sub-groups and are not closely related to those larger language families: In addition, there are also smaller sub-groups within
7344-431: The Tatars of the Middle Volga and multiple groups in the Caucasus, including Chechens , Avars , Ingush and others. With 20th-century migrations, Muslims in Western Europe have become a noticeable minority. According to the Pew Forum , the total number of Muslims in Europe in 2010 was about 44 million (6%), while the total number of Muslims in the European Union in 2007 was about 16 million (3.2%). Judaism has
7480-400: The Westminster tradition . The country's head of government is the prime minister , who holds office by virtue of their ability to command the confidence of the elected House of Commons and is appointed by the governor general , representing the monarch of Canada , the ceremonial head of state . The country is a Commonwealth realm and is officially bilingual (English and French) in
7616-476: The centum group, and Proto-Slavic and Proto-Baltic , of the satem group. A group of Tyrrhenian languages appears to have included Etruscan , Rhaetian , Lemnian , and perhaps Camunic . A pre-Roman stage of Proto-Basque can only be reconstructed with great uncertainty. Regarding the European Bronze Age , the only relatively likely reconstruction is that of Proto-Greek (ca. 2000 BC). A Proto-Italo-Celtic ancestor of both Italic and Celtic (assumed for
7752-400: The displacement of Indigenous populations , and a process of increasing autonomy from the United Kingdom. This increased sovereignty was highlighted by the Statute of Westminster, 1931 , and culminating in the Canada Act 1982 , which severed the vestiges of legal dependence on the Parliament of the United Kingdom . Canada is a parliamentary democracy and a constitutional monarchy in
7888-441: The head of government . To ensure the stability of government, the governor general will usually appoint as prime minister the individual who is the current leader of the political party that can obtain the confidence of a majority of members in the House. The Prime Minister's Office (PMO) is one of the most powerful institutions in government, initiating most legislation for parliamentary approval and selecting for appointment by
8024-449: The sex chromosomes in males . For each SNP, the combination of alleles a person has is called a genotype . Genotyping refers to uncovering what genotype a person has at a particular site. The HapMap project chose a sample of 269 individuals and selected several million well-defined SNPs, genotyped the individuals for these SNPs, and published the results. The alleles of nearby SNPs on a single chromosome are correlated. Specifically, if
8160-445: The "Western World" has been intimately connected with the concept of " Christianity and Christendom " many even attribute Christianity for being the link that created a unified European identity . Christianity is still the largest religion in Europe; according to a 2011 survey, 76.2% of Europeans considered themselves Christians . Also according to a study on Religiosity in the European Union in 2012, by Eurobarometer , Christianity
8296-500: The 10th century gives an account of the Bolghar and the Rus' peoples . William Rubruck , while most notable for his account of the Mongols , in his account of his journey to Asia also gives accounts of the Tatars and the Alans . Saxo Grammaticus and Adam of Bremen give an account of pre-Christian Scandinavia. The Chronicon Slavorum (12th century) gives an account of the northwestern Slavic tribes. Gottfried Hensel in his 1741 Synopsis Universae Philologiae published one of
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#17328516507538432-412: The 1713 Treaty of Utrecht and Canada and most of New France came under British rule in 1763 after the Seven Years' War. The Royal Proclamation of 1763 established First Nation treaty rights, created the Province of Quebec out of New France, and annexed Cape Breton Island to Nova Scotia. St John's Island (now Prince Edward Island ) became a separate colony in 1769. To avert conflict in Quebec ,
8568-482: The 18th and 19th centuries, such as the Americas , and Australasia , and is not restricted to Europe. Since the High Middle Ages , most of Europe has been dominated by Christianity . There are three major denominations: Roman Catholic , Protestant and Eastern Orthodox , with Protestantism restricted mostly to Northern Europe , and Orthodoxy to East and South Slavic regions, Romania , Moldova , Greece , and Georgia . The Armenian Apostolic Church , part of
8704-405: The British Parliament passed the Quebec Act 1774, expanding Quebec's territory to the Great Lakes and Ohio Valley . More importantly, the Quebec Act afforded Quebec special autonomy and rights of self-administration at a time when the Thirteen Colonies were increasingly agitating against British rule. It re-established the French language, Catholic faith, and French civil law there, staving off
8840-458: The CEPH collection); CHB (Han Chinese in Beijing, China); CHD (Chinese in Metropolitan Denver, Colorado); GIH (Gujarati Indians in Houston, Texas); JPT (Japanese in Tokyo, Japan); LWK (Luhya in Webuye, Kenya); MEX (Mexican ancestry in Los Angeles, California); MKK (Maasai in Kinyawa, Kenya); TSI (Tuscans in Italy); YRI (Yoruba in Ibadan, Nigeria). Three combined panels have also been created, which allow better identification of SNPs in groups outside
8976-466: The Canadian military ". Canada sent troops to Afghanistan in 2001 , resulting in the largest amount of Canadian deaths for any single military mission since the Korean War in the early 1950s. In 2011, Canadian forces participated in the NATO-led intervention into the Libyan Civil War and also became involved in battling the Islamic State insurgency in Iraq in the mid-2010s. The country celebrated its sesquicentennial in 2017, three years before
9112-423: The Crown the governor general, lieutenant governors , senators, federal court judges, and heads of Crown corporations and government agencies. The leader of the party with the second-most seats usually becomes the leader of the Official Opposition and is part of an adversarial parliamentary system intended to keep the government in check. The Parliament of Canada passes all federal statute laws. It comprises
9248-439: The First Nations to education, government and legal rights. Because Britain still maintained control of Canada's foreign affairs under the British North America Act, 1867, its declaration of war in 1914 automatically brought Canada into the First World War . Volunteers sent to the Western Front later became part of the Canadian Corps , which played a substantial role in the Battle of Vimy Ridge and other major engagements of
9384-449: The HapMap: 30 adult-and-both-parents Yoruba trios from Ibadan , Nigeria (YRI), 30 trios of Utah residents of northern and western European ancestry (CEU), 44 unrelated Japanese individuals from Tokyo , Japan (JPT) and 45 unrelated Han Chinese individuals from Beijing , China (CHB). Although the haplotypes revealed from these populations should be useful for studying many other populations, parallel studies are currently examining
9520-411: The Métis' grievances ignited the Red River Rebellion and the creation of the province of Manitoba in July 1870. British Columbia and Vancouver Island (which had been united in 1866) joined the confederation in 1871 on the promise of a transcontinental railway extending to Victoria in the province within 10 years, while Prince Edward Island joined in 1873. In 1898, during the Klondike Gold Rush in
9656-438: The Norse built a small short-lived encampment that was occupied sporadically for perhaps 20 years at L'Anse aux Meadows on the northern tip of Newfoundland . No further European exploration occurred until 1497, when seafarer John Cabot explored and claimed Canada's Atlantic coast in the name of Henry VII of England . In 1534, French explorer Jacques Cartier explored the Gulf of Saint Lawrence where, on July 24, he planted
9792-700: The Northwest Territories, Parliament created the Yukon Territory. Alberta and Saskatchewan became provinces in 1905. Between 1871 and 1896, almost one quarter of the Canadian population emigrated south to the US. To open the West and encourage European immigration, the Government of Canada sponsored the construction of three transcontinental railways (including the Canadian Pacific Railway ), passed
9928-454: The Parliament of Canada. European ethnic groups This is an accepted version of this page Europeans are the focus of European ethnology , the field of anthropology related to the various ethnic groups that reside in the states of Europe . Groups may be defined by common ancestry, common language, common faith, etc. The total number of national minority populations in Europe
10064-621: The Saint Lawrence River. Following the British conquest of New France , this area was known as the British Province of Quebec from 1763 to 1791. In 1791, the area became two British colonies called Upper Canada and Lower Canada . These two colonies were collectively named the Canadas until their union as the British Province of Canada in 1841. Upon Confederation in 1867 , Canada
10200-682: The United Kingdom. The delay underscored Canada's independence. The first Canadian Army units arrived in Britain in December 1939. In all, over a million Canadians served in the armed forces during the Second World War . Canadian troops played important roles in many key battles of the war, including the failed 1942 Dieppe Raid , the Allied invasion of Italy , the Normandy landings , the Battle of Normandy , and
10336-594: The United States is the world's longest international land border. The country is characterized by a wide range of both meteorologic and geological regions. With a population of just over 41 million people, it has widely varying population densities, with the majority residing in urban areas and large areas of the country being sparsely populated. Canada's capital is Ottawa and its three largest metropolitan areas are Toronto , Montreal , and Vancouver . Indigenous peoples have continuously inhabited what
10472-617: The United States in 1846 ended the Oregon boundary dispute , extending the border westward along the 49th parallel . This paved the way for British colonies on Vancouver Island (1849) and in British Columbia (1858) . The Anglo-Russian Treaty of Saint Petersburg (1825) established the border along the Pacific coast, but, even after the US Alaska Purchase of 1867, disputes continued about
10608-753: The United States or Canada with regards to who settled where. Some groups that claim Indigenous minority status in Europe include the Uralic Nenets , Samoyed , and Komi peoples of northern Russia; Circassians of southern Russia and the North Caucasus ; Crimean Tatars , Krymchaks and Crimean Karaites of Crimea (Ukraine); Sámi peoples of northern Norway , Sweden , and Finland and northwestern Russia (in an area also referred to as Sápmi ); Galicians of Galicia , Spain ; Catalans of Catalonia , Spain and southern France ; Basques of Basque Country , Spain and southern France ; Gaels of Ireland ,
10744-466: The abortive Rebellions of 1837 . The Durham Report subsequently recommended responsible government and the assimilation of French Canadians into English culture. The Act of Union 1840 merged the Canadas into a united Province of Canada and responsible government was established for all provinces of British North America east of Lake Superior by 1855. The signing of the Oregon Treaty by Britain and
10880-484: The allele of one SNP for a given individual is known, the alleles of nearby SNPs can often be predicted, a process known as genotype imputation . This is because each SNP arose in evolutionary history as a single point mutation , and was then passed down on the chromosome surrounded by other, earlier, point mutations. SNPs that are separated by a large distance on the chromosome are typically not very well correlated, because recombination occurs in each generation and mixes
11016-503: The allele sequences of the two chromosomes. A sequence of consecutive alleles on a particular chromosome is known as a haplotype . To find the genetic factors involved in a particular disease, one can proceed as follows. First a certain region of interest in the genome is identified, possibly from earlier inheritance studies. In this region one locates a set of tag SNPs from the HapMap data; these are SNPs that are very well correlated with all
11152-732: The ancient Sardinian and Corsican peoples. The 4th century Tabula Peutingeriana records the names of numerous peoples and tribes. Ethnographers of Late Antiquity such as Agathias of Myrina , Ammianus Marcellinus , Jordanes , and Theophylact Simocatta give early accounts of the Slavs , the Franks , the Alamanni and the Goths . Book IX of Isidore 's Etymologiae (7th century) treats de linguis, gentibus, regnis, militia, civibus (concerning languages, peoples, realms, war and cities). Ahmad ibn Fadlan in
11288-508: The categorisation of Europeans into clearly defined racial groups. A 2007 study on the genetic history of Europe found that the most important genetic differentiation in Europe occurs on a line from the north to the south-east (northern Europe to the Balkans), with another east–west axis of differentiation across Europe, separating the indigenous Basques , Sardinians and Sami from other European populations. Despite these stratifications it noted
11424-707: The centre of the political scale. Five parties had representatives elected to the Parliament in the 2021 election —the Liberals, who formed a minority government; the Conservatives, who became the Official Opposition ; the New Democratic Party (occupying the left ); the Bloc Québécois ; and the Green Party . Far-right and far-left politics have never been a prominent force in Canadian society. Canada has
11560-681: The complete data obtained in Phase I were published on 27 October 2005. The analysis of the Phase II dataset was published in October 2007. The Phase III dataset was released in spring 2009 and the publication presenting the final results published in September 2010. Unlike with the rarer Mendelian diseases, combinations of different genes and the environment play a role in the development and progression of common diseases (such as diabetes , cancer , heart disease , stroke , depression , and asthma ), or in
11696-548: The constitution. The Supreme Court of Canada is the highest court, final arbiter, and has been led since 2017 by Richard Wagner , the Chief Justice of Canada . The governor general appoints the court's nine members on the advice of the prime minister and minister of justice . The federal Cabinet also appoints justices to superior courts in the provincial and territorial jurisdictions. Common law prevails everywhere except Quebec, where civil law predominates. Criminal law
11832-509: The continent during the North American fur trade . These early European interactions with First Nations would change from friendship and peace treaties to the dispossession of Indigenous lands through treaties . From the late 18th century, European Canadians forced Indigenous peoples to assimilate into a western Canadian society. Settler colonialism reached a climax in the late 19th and early 20th centuries. A period of redress began with
11968-557: The country and consists of written text and unwritten conventions. The Constitution Act, 1867 (known as the British North America Act, 1867 prior to 1982), affirmed governance based on parliamentary precedent and divided powers between the federal and provincial governments. The Statute of Westminster, 1931 , granted full autonomy, and the Constitution Act, 1982 , ended all legislative ties to Britain, as well as adding
12104-421: The country, particularly in the interior and Prairie provinces, which experience a continental climate , where daily average temperatures are near −15 °C (5 °F ), but can drop below −40 °C (−40 °F) with severe wind chills . In non-coastal regions, snow can cover the ground for almost six months of the year, while in parts of the north snow can persist year-round. Coastal British Columbia has
12240-404: The current European population. Both Spain and the United Kingdom are special cases, in that the designation of nationality , Spanish and British , may controversially take ethnic aspects, subsuming various regional ethnic groups (see nationalisms and regionalisms of Spain and native populations of the United Kingdom ). Switzerland is a similar case, but the linguistic subgroups of
12376-445: The earliest ethno-linguistic map of Europe, showing the beginning of the pater noster in the various European languages and scripts. In the 19th century, ethnicity was discussed in terms of scientific racism , and the ethnic groups of Europe were grouped into a number of " races ", Mediterranean , Alpine and Nordic , all part of a larger " Caucasian " group. The beginnings of ethnic geography as an academic subdiscipline lie in
12512-577: The early 1930s saw an economic downturn, leading to hardship across the country. In response to the downturn, the Co-operative Commonwealth Federation (CCF) in Saskatchewan introduced many elements of a welfare state (as pioneered by Tommy Douglas ) in the 1940s and 1950s. On the advice of Prime Minister William Lyon Mackenzie King , war with Germany was declared effective September 10, 1939, by King George VI , seven days after
12648-624: The emergence of a new Canadian identity , marked by the adoption of the maple leaf flag in 1965, the implementation of official bilingualism (English and French) in 1969, and the institution of official multiculturalism in 1971. Socially democratic programs were also instituted, such as Medicare , the Canada Pension Plan , and Canada Student Loans ; though, provincial governments, particularly Quebec and Alberta, opposed many of these as incursions into their jurisdictions. Finally, another series of constitutional conferences resulted in
12784-663: The exact demarcation of the Alaska–Yukon and Alaska–BC border. Following three constitutional conferences, the British North America Act, 1867 officially proclaimed Canadian Confederation on July 1, 1867, initially with four provinces: Ontario , Quebec, Nova Scotia, and New Brunswick. Canada assumed control of Rupert's Land and the North-Western Territory to form the Northwest Territories , where
12920-416: The federal government and the 10 provinces. Provincial legislatures are unicameral and operate in parliamentary fashion similar to the House of Commons. Canada's three territories also have legislatures, but these are not sovereign, have fewer constitutional responsibilities than the provinces, and differ structurally from their provincial counterparts. The Constitution of Canada is the supreme law of
13056-488: The federal jurisdiction. It is very highly ranked in international measurements of government transparency, quality of life, economic competitiveness, innovation, education and human rights. It is one of the world's most ethnically diverse and multicultural nations, the product of large-scale immigration . Canada's long and complex relationship with the United States has had a significant impact on its history , economy , and culture . A developed country , Canada has
13192-534: The first permanent year-round European settlements at Port Royal (in 1605) and Quebec City (in 1608). Among the colonists of New France, Canadiens extensively settled the Saint Lawrence River valley and Acadians settled the present-day Maritimes , while fur traders and Catholic missionaries explored the Great Lakes , Hudson Bay , and the Mississippi watershed to Louisiana . The Beaver Wars broke out in
13328-493: The formation of a reconciliation commission by the Government of Canada in 2008. This included acknowledgment of cultural genocide , settlement agreements , and betterment of racial discrimination issues, such as addressing the plight of missing and murdered Indigenous women . It is believed that the first documented European to explore the east coast of Canada was Norse explorer Leif Erikson . In approximately 1000 AD,
13464-541: The fur trade, conflicts with the colonial authorities and settlers, and the loss of Indigenous lands to settlers and the subsequent collapse of several nations' self-sufficiency. Although not without conflict, European Canadians ' early interactions with First Nations and Inuit populations were relatively peaceful. First Nations and Métis peoples played a critical part in the development of European colonies in Canada , particularly for their role in assisting European coureurs des bois and voyageurs in their explorations of
13600-485: The genome by David R. Cox, Kelly A. Frazer and others at Perlegen Sciences and 500,000 by the company Affymetrix . All of the data generated by the project, including SNP frequencies, genotypes and haplotypes , were placed in the public domain and are available for download. This website also contains a genome browser which allows to find SNPs in any region of interest, their allele frequencies and their association to nearby SNPs. A tool that can determine tag SNPs for
13736-445: The great number of perspectives which can be taken on the subject, it is impossible to form a single, all-embracing conception of European culture. Nonetheless, there are core elements which are generally agreed upon as forming the cultural foundation of modern Europe. One list of these elements given by K. Bochmann includes: Berting says that these points fit with "Europe's most positive realisations". The concept of European culture
13872-586: The growth of an independence movement in contrast to the Thirteen Colonies. The Proclamation and the Quebec Act in turn angered many residents of the Thirteen Colonies, further fuelling anti-British sentiment in the years prior to the American Revolution . After the successful American War of Independence, the 1783 Treaty of Paris recognized the independence of the newly formed United States and set
14008-542: The human genome free of variants that damage health before children are grown, the theory held, but fails against variants that strike later in life, allowing them to become quite common (In 2002 the National Institutes of Health started a $ 138 million project called the HapMap to catalog the common variants in European, East Asian and African genomes). For the Phase I, one common SNP was genotyped every 5,000 bases. Overall, more than one million SNPs were genotyped. The genotyping
14144-456: The individual response to pharmacological agents. To find the genetic factors involved in these diseases, one could in principle do a genome-wide association study : obtain the complete genetic sequence of several individuals, some with the disease and some without, and then search for differences between the two sets of genomes. At the time, this approach was not feasible because of the cost of full genome sequencing . The HapMap project proposed
14280-509: The introduction of European cattle farms and wheat fields dominating the land. The Indigenous peoples saw widespread famine and disease due to the loss of the bison and their traditional hunting lands. The federal government did provide emergency relief, on condition of the Indigenous peoples moving to the reserves. During this time, Canada introduced the Indian Act extending its control over
14416-408: The last 1700 years. Modern philosophical thought has very much been influenced by Christian philosophers such as St Thomas Aquinas and Erasmus, and throughout most of its history, Europe has been nearly equivalent to Christian culture . The Christian culture was the predominant force in western civilization , guiding the course of philosophy , art , and science . The notion of "Europe" and
14552-705: The main front in the War of 1812 between the United States and the United Kingdom . Peace came in 1815; no boundaries were changed. Immigration resumed at a higher level, with over 960,000 arrivals from Britain between 1815 and 1850. New arrivals included refugees escaping the Great Irish Famine as well as Gaelic -speaking Scots displaced by the Highland Clearances . Infectious diseases killed between 25 and 33 percent of Europeans who immigrated to Canada before 1891. The desire for responsible government resulted in
14688-401: The majority of the population in only two European countries: Czech Republic (76%) and Estonia (60%). " Pan-European identity " or " Europatriotism " is an emerging sense of personal identification with Europe, or the European Union as a result of the gradual process of European integration taking place over the last quarter of the 20th century, and especially in the period after the end of
14824-659: The mid-17th century over control of the North American fur trade. The English established additional settlements in Newfoundland in 1610 along with settlements in the Thirteen Colonies to the south. A series of four wars erupted in colonial North America between 1689 and 1763; the later wars of the period constituted the North American theatre of the Seven Years' War . Mainland Nova Scotia came under British rule with
14960-672: The monarch, the House of Commons, and the Senate . While Canada inherited the British concept of parliamentary supremacy , this was later, with the enactment of the Constitution Act, 1982, all but completely superseded by the American notion of the supremacy of the law . Each of the 338 members of Parliament in the House of Commons is elected by simple plurality in an electoral district or riding. The Constitution Act, 1982 , requires that no more than five years pass between elections, although
15096-630: The name of the national holiday was changed from Dominion Day to Canada Day . The first inhabitants of North America are generally hypothesized to have migrated from Siberia by way of the Bering land bridge and arrived at least 14,000 years ago. The Paleo-Indian archeological sites at Old Crow Flats and Bluefish Caves are two of the oldest sites of human habitation in Canada. The characteristics of Indigenous societies included permanent settlements, agriculture, complex societal hierarchies, and trading networks. Some of these cultures had collapsed by
15232-665: The nine homogenous samples: CEU+TSI (Combined panel of Utah residents with Northern and Western European ancestry from the CEPH collection and Tuscans in Italy); JPT+CHB (Combined panel of Japanese in Tokyo, Japan and Han Chinese in Beijing, China) and JPT+CHB+CHD (Combined panel of Japanese in Tokyo, Japan, Han Chinese in Beijing, China and Chinese in Metropolitan Denver, Colorado). CEU+TSI, for instance,
15368-538: The other SNPs in the region. Using these, genotype imputation can be used to determine (impute) the other SNPs and thus the entire haplotype with high confidence. Next, one determines the genotype for these tag SNPs in several individuals, some with the disease and some without. By comparing the two groups, one determines the likely locations and haplotypes that are involved in the disease. Haplotypes are generally shared between populations, but their frequency can differ widely. Four populations were selected for inclusion in
15504-460: The participation of national minorities in public life. The Framework Convention for the Protection of National Minorities defines a national minority implicitly to include minorities possessing a territorial identity and a distinct cultural heritage. By 2008, 39 member states had signed and ratified the convention, with the notable exception of France . Definitions of what constitutes Indigenous minority groups in Europe can vary widely. One criterion
15640-457: The period following World War I, in the context of nationalism , and in the 1930s exploitation for the purposes of fascist and Nazi propaganda , so that it was only in the 1960s that ethnic geography began to thrive as a bona fide academic subdiscipline. The origins of modern ethnography are often traced to the work of Bronisław Malinowski , who emphasized the importance of fieldwork. The emergence of population genetics further undermined
15776-552: The permafrost is uncertain because the Arctic has been warming at three times the global average as a result of climate change in Canada . Canada's annual average temperature over land has risen by 1.7 °C (3.1 °F), with changes ranging from 1.1 to 2.3 °C (2.0 to 4.1 °F) in various regions, since 1948. The rate of warming has been higher across the North and in the Prairies. In
15912-488: The provinces collect more revenue than the federal government, equalization payments are made by the federal government to ensure reasonably uniform standards of services and taxation are kept between the richer and poorer provinces. The major difference between a Canadian province and a territory is that provinces receive their sovereignty from the Crown and power and authority from the Constitution Act, 1867 , whereas territorial governments have powers delegated to them by
16048-807: The rights they support were reaffirmed by section 35 of the Constitution Act, 1982 . These rights may include provision of services, such as healthcare through the Indian Health Transfer Policy , and exemption from taxation. Canada is a federation composed of 10 federated states , called provinces, and three federal territories . These may be grouped into four main regions : Western Canada , Central Canada , Atlantic Canada , and Northern Canada ( Eastern Canada refers to Central Canada and Atlantic Canada together). Provinces and territories have responsibility for social programs such as healthcare , education , and social programs , as well as administration of justice (but not criminal law). Although
16184-637: The situation specific to the individual countries of Europe. In 2021, the number of non-EU nationals living in EU members states was 23.7 million (5.3% of the EU population). The countries with the largest population of non-nationals were Germany, Spain, France and Italy. These four Member States represented 70.3% of all non-EU nationals living in the EU Member States. The population of the European Union , with some 450 million residents, accounts for two thirds of
16320-740: The southeast. Canada is also home to the world's northernmost settlement, Canadian Forces Station Alert , on the northern tip of Ellesmere Island —latitude 82.5°N—which lies 817 kilometres (508 mi) from the North Pole. In latitude, Canada's most northerly point of land is Cape Columbia in Nunavut at 83°6′41″N, with its southern extreme at Middle Island in Lake Erie at 41°40′53″N. In longitude, Canada's land extends from Cape Spear , Newfoundland, at 52°37'W, to Mount St. Elias , Yukon Territory, at 141°W. Canada can be divided into seven physiographic regions:
16456-485: The southern regions of Canada, air pollution from both Canada and the United States—caused by metal smelting, burning coal to power utilities, and vehicle emissions—has resulted in acid rain , which has severely impacted waterways, forest growth, and agricultural productivity. Canada is one of the largest greenhouse gas emitters globally , with emissions increased by 16.5 percent between 1990 and 2022. Canada
16592-552: The terms of peace, ceding British North American territories south of the Great Lakes and east of the Mississippi River to the new country. The American war of independence also caused a large out-migration of Loyalists , the settlers who had fought against American independence. Many moved to Canada, particularly Atlantic Canada, where their arrival changed the demographic distribution of the existing territories. New Brunswick
16728-501: The time European explorers arrived in the late 15th and early 16th centuries and have only been discovered through archeological investigations. Indigenous peoples in present-day Canada include the First Nations , Inuit , and Métis , the last being of mixed descent who originated in the mid-17th century when First Nations people married European settlers and subsequently developed their own identity. The Indigenous population at
16864-446: The time of the first European settlements is estimated to have been between 200,000 and two million, with a figure of 500,000 accepted by Canada's Royal Commission on Aboriginal Peoples . As a consequence of European colonization, the Indigenous population declined by forty to eighty percent. The decline is attributed to several causes, including the transfer of European diseases , to which they had no natural immunity, conflicts over
17000-453: The unusually high degree of European homogeneity: "there is low apparent diversity in Europe with the entire continent-wide samples only marginally more dispersed than single population samples elsewhere in the world." The total number of national minority populations in Europe is estimated at 105 million people, or 14% of Europeans. The member states of the Council of Europe in 1995 signed
17136-611: The usefulness of including additional populations in the project. All samples were collected through a community engagement process with appropriate informed consent. The community engagement process was designed to identify and attempt to respond to culturally specific concerns and give participating communities input into the informed consent and sample collection processes. In phase III, 11 global ancestry groups have been assembled: ASW (African ancestry in Southwest USA); CEU (Utah residents with Northern and Western European ancestry from
17272-472: The village of Stadacona . Cartier later used the word Canada to refer not only to that particular village but to the entire area subject to Donnacona (the chief at Stadacona); by 1545, European books and maps had begun referring to this small region along the Saint Lawrence River as Canada . From the 16th to the early 18th century, Canada referred to the part of New France that lay along
17408-532: The war with a large army and strong economy. The financial crisis of the Great Depression led the Dominion of Newfoundland to relinquish responsible government in 1934 and become a Crown colony ruled by a British governor. After two referendums , Newfoundlanders voted to join Canada in 1949 as a province. Canada's post-war economic growth, combined with the policies of successive Liberal governments, led to
17544-582: The war. The Conscription Crisis of 1917 erupted when the Unionist Cabinet's proposal to augment the military's dwindling number of active members with conscription was met with vehement objections from French-speaking Quebecers. In 1919, Canada joined the League of Nations independently of Britain, and the Statute of Westminster, 1931 , affirmed Canada's independence. The Great Depression in Canada during
17680-459: The world's longest coastline of 243,042 kilometres (151,019 mi). In addition to sharing the world's largest land border with the United States —spanning 8,891 km (5,525 mi) —Canada shares a land border with Greenland (and hence the Kingdom of Denmark ) to the northeast, on Hans Island , and a maritime boundary with France 's overseas collectivity of Saint Pierre and Miquelon to
17816-595: Was adopted as the legal name for the new country at the London Conference and the word dominion was conferred as the country's title. By the 1950s, the term Dominion of Canada was no longer used by the United Kingdom, which considered Canada a "realm of the Commonwealth". The Canada Act 1982 , which brought the Constitution of Canada fully under Canadian control, referred only to Canada . Later that year,
17952-675: Was carried out by 10 centres using five different genotyping technologies. Genotyping quality was assessed by using duplicate or related samples and by having periodic quality checks where centres had to genotype common sets of SNPs. The Canadian team was led by Thomas J. Hudson at McGill University in Montreal and focused on chromosomes 2 and 4p. The Chinese team was led by Huanming Yang in Beijing and Shanghai , and Lap-Chee Tsui in Hong Kong and focused on chromosomes 3, 8p and 21. The Japanese team
18088-442: Was estimated to be approximately 1.4 million (0.2% of European population) or 10% of the world's Jewish population. In the 21st century, France has the largest Jewish population in Europe , followed by the United Kingdom, Germany, Russia and Ukraine. In modern times, significant secularization since the 20th century, notably in secularist France , Estonia and the Czech Republic. Currently, distribution of theism in Europe
18224-507: Was in turn split from Nova Scotia as part of a reorganization of Loyalist settlements in the Maritimes, which led to the incorporation of Saint John, New Brunswick , as Canada's first city. To accommodate the influx of English-speaking Loyalists in Central Canada, the Constitutional Act of 1791 divided the province of Canada into French-speaking Lower Canada (later Quebec ) and English-speaking Upper Canada (later Ontario ), granting each its own elected legislative assembly. The Canadas were
18360-413: Was led by Yusuke Nakamura at the University of Tokyo and focused on chromosomes 5, 11, 14, 15, 16, 17 and 19. The British team was led by David R. Bentley at the Sanger Institute and focused on chromosomes 1, 6, 10, 13 and 20. There were four United States' genotyping centres: a team led by Mark Chee and Arnold Oliphant at Illumina Inc. in San Diego (studying chromosomes 8q, 9, 18q, 22 and X),
18496-430: Was passed by Parliament, outlining the terms of a negotiated departure from Confederation. In addition to the issues of Quebec sovereignty, a number of crises shook Canadian society in the late 1980s and early 1990s. These included the explosion of Air India Flight 182 in 1985, the largest mass murder in Canadian history; the École Polytechnique massacre in 1989, a university shooting targeting female students; and
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