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90-546: Garnier ( French pronunciation: [ɡaʁnje] ) is a mass market cosmetics brand of French cosmetics company L'Oréal and Beiersdorf . produces hair care and skin care products. Laboratoires Garnier was founded in France in 1904 by Alfred Amour Garnier. The company's first product was a patented as the first hair lotion derived from natural plant ingredients. The company then introduced sun-care products in 1936, followed by permanent home hair color in 1960. Over

180-577: A dietary supplement or food additive, retinol is stabilized as the ester derivatives retinyl acetate or retinyl palmitate . Prior to 1999, three companies, Roche, BASF and Rhone-Poulenc controlled 96% of global vitamin A sales. In 2001, the European Commission imposed total fines of 855.22 Euros on these and five other companies for their participation in eight distinct market-sharing and price-fixing cartels that dated back to 1989. Roche sold its vitamin division to DSM in 2003. DSM and BASF have

270-556: A fat-soluble nutrient in butterfat and cod liver oil . Their work confirmed that of Thomas Burr Osborne and Lafayette Mendel , at Yale , also in 1913, which suggested a fat-soluble nutrient in butterfat. The "accessory factors" were termed "fat soluble" in 1918 and later "vitamin A" in 1920. In 1931, Swiss chemist Paul Karrer described the chemical structure of vitamin A. Retinoic acid and retinol were first synthesized in 1946 and 1947 by two Dutch chemists, David Adriaan van Dorp and Jozef Ferdinand Arens. In 1967, George Wald

360-574: A hot topic in medical spaces such as dermatology, due to the increase of young girls using anti-aging cream, despite only being around 11 years old. In the United States, "Under the law, cosmetic products and ingredients do not need FDA premarket approval." The EU and other regulatory agencies around the world have more stringent regulations. The FDA does not have to approve or review cosmetics, or what goes in them, before they are sold to consumers. The FDA only regulates some colors that can be used in

450-634: A light-activated molecular switch. When 11- cis -retinal absorbs light it isomerizes into all- trans -retinal. The change in the shape of the molecule in turn changes the configuration of the opsin in a cascade that leads to the neuronal firing , which signals the detection of light. The opsin then splits into the protein component (such metarhodopsin ) and the cofactor all- trans -retinal. The regeneration of active opsin requires conversion of all- trans -retinal back to 11- cis -retinal via retinol. The regeneration of 11- cis -retinal occurs in vertebrates via conversion of all- trans -retinol to 11- cis -retinol in

540-404: A method developed by BASF or a Grignard reaction utilized by Hoffman-La Roche . The two major suppliers, DSM and BASF, are believed to use total synthesis. The world market for synthetic retinol is primarily for animal feed, leaving approximately 13% for a combination of food, prescription medication and dietary supplement use. The first industrialized synthesis of retinol was achieved by

630-750: A nerve signal to the brain. The all-trans retinal is reduced to all-trans retinol and travels back to the retinal pigment epithelium to be recycled to 11-cis retinal and conjugated to opsin. Although vitamin A was not confirmed as an essential nutrient and a chemical structure described until the 20th century, written observations of conditions created by deficiency of this nutrient appeared much earlier in history. Sommer classified historical accounts related to vitamin A and/or manifestations of deficiency as follows: "ancient" accounts; 18th- to 19th-century clinical descriptions (and their purported etiologic associations); early 20th-century laboratory animal experiments, and clinical and epidemiologic observations that identified

720-471: A person ingests vitamin A in large amounts more than the daily recommended value in the threshold of 25,000 IU/kg or more. Often, the patient consumes about 3–4 times the RDA's specification. Toxicity of vitamin A is believed to be associated with the methods of increasing vitamin A in the body, such as food modification, fortification, and supplementation, all of which are used to combat vitamin A deficiency. Toxicity

810-656: A person's face. In some cases, more extreme forms of makeup are used for performances, fashion shows , and people in costume and can change the appearance of the face entirely to resemble a different person, creature, or object. Techniques for changing appearance include contouring , which aims to give shape to an area of the face. Cosmetics can also be designed to add fragrance to the body. Products used for haircare , such as permanent waves, hair colors , and hairsprays , are classified as cosmetic products as well. Cosmetics have been in use for thousands of years, with ancient Egyptians and Sumerians using them. In Europe,

900-493: A result, many celebrities and influencers actively promote skincare routines or collaborate with beauty brands, making skincare and makeup more aspirational Alpha is also inspired by the "clean beauty" movement and inclusive beauty brands that champion self-expression, allowing them to feel more confident in exploring skincare and makeup." In 2023 and 2024, many people posting on social media have reported seeing girls, ranging from 10 to 12 in age in popular cosmetic stores, such as

990-411: A sequence of chemical transformations that occurs primarily in the pigment epithelial cells. Without adequate amounts of retinol, regeneration of rhodopsin is incomplete and night blindness occurs. Night blindness, the inability to see well in dim light, is associated with a deficiency of vitamin A , a class of compounds that includes retinol and retinal. In the early stages of vitamin A deficiency,

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1080-610: A study concluding that makeup makes women seem more competent. Due to the source of funding, the quality of this Boston University study is questioned. Cosmetics products may be retailed in beauty stores , department stores and hypermarkets , drugstores , variety stores , grocery stores , beauty supply stores, and many other formats, and in similar types of online stores or the online presence of these types of physical stores. Cosmetic companies have changed their traditional methods of marketing by using social media influencers and brand ambassadors to market their products. During

1170-584: A variety of petrochemically derived agents. Inorganic compounds are processed minerals such as iron oxides , talc , and zinc oxide . The oxides of zinc and iron are classified as pigments , i.e., colorants that have no solubility in solvents. Cosmetic companies have become more transparent in the ingredients of their products because consumers are interested in the formula of their products. Handmade and certified organic products are becoming more mainstream due to consumer concerns that certain chemicals in some skincare products may be harmful if absorbed through

1260-421: A wide range of cosmetics, including such products as lipstick , eye liner , mascara , foundation , concealer , lip balm , blush , nail polish . A 2021 study tested 231 personal care products and found organic fluorine, a hallmark of PFAS, in more than half of the samples. Substantial levels of fluorine were identified in tested brands of products as follows: 82% of the brands of waterproof mascara, 63% of

1350-669: Is a legal requirement for cosmetic products. Cosmetics People have used cosmetics for thousands of years for skin care and appearance enhancement. Visible cosmetics for women and men have gone in and out of fashion over the centuries. Some early forms of cosmetics used harmful ingredients such as lead that caused serious health problems and sometimes resulted in death. Modern commercial cosmetics are generally tested for safety but may contain controversial ingredients, such as per- and polyfluoroalkyl substances (PFAS), formaldehyde releasers , and ingredients that cause allergic reactions. The European Union and regulatory agencies around

1440-538: Is a standard step in skin care routines. Skin cleansing includes some or all of these steps or cosmetics: Hair care is a category of cosmetics devoted to products which are used to improve the appearance of hair. Perfumes or fragrances, are liquids that can be sprayed or applied to produce a long-lasting smell. They are created by mixing different compounds together. There are different groups of perfumes which are categorised according to their concentration. The difference between Eau de parfum and Eau de toilette

1530-523: Is also an important player in the European cosmetic market. Although not as large as in other European countries , the cosmetic industry in Italy was estimated to reach €9 billion in 2007. The Italian cosmetic industry is dominated by hair and body products and not makeup as in many other European countries. In Italy, hair and body products make up approximately 30% of the cosmetic market. Makeup and facial care are

1620-545: Is also used to reduce the risk of complications in measles patients. The Recommended Daily Intake (RDA) for preformed supplemental vitamin A for adult men and women is 900 and 700 Retinol Activity Units(RAE)/day, respectively, or about 3,000 IU and 2,300 IU. In pregnancy, the vitamin A RDA is 750–770 RAE/day (about 2,500–2,550 IU). During lactation , the RDA increases to 1,200–1,300 RAE/day (about 4,000–4,300 IU, with differences depending on age). Retinol Activity Units can only be converted to IU (International Units) when

1710-463: Is an essential compound in the cycle of light-activated chemical reactions called the " visual cycle " that underlies vertebrate vision. Retinol is converted by the protein RPE65 within the pigment epithelium of the retina into 11- cis -retinal. This molecule is then transported into the retina 's photoreceptor cells (the rod or cone cells in mammals) where it binds to an opsin protein and acts as

1800-401: Is carried by the blood and delivered to the target cells and tissues. The Dietary Reference Intake (DRI) Recommended Daily Amount (RDA) for vitamin A for a 25-year-old male is 900 micrograms/day, or 3000 IU. National Health Service daily recommended values are slightly lower at 700 micrograms for men and 600 micrograms for women. During the absorption process in the intestines , retinol

1890-563: Is classified into two categories: acute and chronic. The former occurs a few hours or days after ingestion of a large amount of vitamin A. Chronic toxicity takes place when about 4,000 IU/kg or more of vitamin A is consumed for a long time. Symptoms of both include nausea, blurred vision, fatigue, weight-loss, and menstrual abnormalities. Excess vitamin A is suspected to be a contributor to osteoporosis . This seems to happen at much lower doses than those required to induce acute intoxication. Only preformed vitamin A can cause these problems, because

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1980-443: Is common in developing countries but rarely seen in developed countries. Approximately 250,000 to 500,000 malnourished children in the developing world go blind each year from a deficiency of vitamin A. Vitamin A deficiency in expecting mothers increases the mortality rate of children shortly after childbirth. Night blindness is one of the first signs of vitamin A deficiency. Vitamin A deficiency contributes to blindness by depleting

2070-479: Is dangerous to human health, especially when inhaled. In 2011, the US National Toxicology Program described formaldehyde as " known to be a human carcinogen ". The danger of formaldehyde is a major reason for the development of formaldehyde releasers which release formaldehyde slowly at lower levels. Retinol Retinol , also called vitamin A 1 , is a fat-soluble vitamin in

2160-569: Is especially aimed at darker skin tones. On 05 March 2021, Cruelty Free International announced that Garnier had been approved as Cruelty Free under the Leaping Bunny programme. Many, but not necessarily all, of Garnier's products are also labelled as 'Vegan'. Garnier is still part of the L'Oreal group, which although claims not to test on animals, has not received Cruelty Free status on account of having an active market in China, where animal testing

2250-525: Is incorporated into chylomicrons as the ester form, and it is these particles that mediate transport to the liver . Liver cells store vitamin A as the ester, and when retinol is needed in other tissues, it is de-esterifed and released into the blood as the alcohol. Retinol then attaches to a serum carrier, retinol binding protein , for transport to target tissues. A binding protein inside cells, cellular retinoic acid binding protein, serves to store and move retinoic acid intracellularly . Vitamin A deficiency

2340-511: Is involved in maintaining a number of immune cell types from both the innate and acquired immune systems. These include the lymphocytes ( B-cells , T-cells , and natural killer cells ), as well as many myelocytes ( neutrophils , macrophages , and myeloid dendritic cells ). Vitamin A maintains immune barriers in the gut through its activity as retinoic acid. Deficiencies in vitamin A have been linked to an increased susceptibility to skin infection and inflammation. Vitamin A appears to modulate

2430-463: Is known as "K-beauty," and it has been popularized by K-pop idols, actors, and social media influencers. Many of these idols have become beauty icons and have allowed many men to access beauty products and to feel comfortable using them. While there may still be some societal pressure to conform to traditional gender norms, there is also a growing acceptance of individual expression and breaking free from traditional gender roles. "The Sephora Kids are

2520-454: Is more about the perfume oil concentration. Eau de parfum has a higher concentration of perfume than Eau de toilette . Various tools are used to apply cosmetics. In addition to brushes, a makeup sponge is a popular applicator. Makeup sponges can be used to apply foundation, blend concealer, and apply powder or highlighter. Loofahs , microfiber cloths, natural sponges, or brushes may be used to exfoliate skin simply by rubbing them over

2610-551: Is necessary for fetal development, most women carry sufficient stores of vitamin A in their liver cells, so over-supplementation should be strictly avoided. A review of all randomized controlled trials in the scientific literature by the Cochrane Collaboration published in JAMA in 2007 found that supplementation with beta carotene or vitamin A increased mortality by 5% and 16%, respectively. This effect has been attributed to

2700-469: Is not present the last four rhombomeres do not develop. Instead, rhombomeres 1–4 grow to cover the same amount of space as all eight would normally occupy. Retinoic acid has its effects by turning on a differential pattern of Homeobox (Hox) genes that encode different homeodomain transcription factors which in turn can turn on cell type specific genes. Deletion of the Homeobox (Hox-1) gene from rhombomere 4 makes

2790-403: Is shown to promote the development of many cancers. There are two sources of dietary vitamin A. Retinyl ester or retinol forms, which are immediately available to the body or carotene precursors, also known as provitamins, which must be converted to active forms by the body. These are obtained from fruits and vegetables containing yellow, orange and dark green pigments, known as carotenoids ,

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2880-436: Is taken by mouth or by injection into a muscle . As an ingredient in skin-care products, it is used to reduce wrinkles and other effects of skin aging. Retinol at normal doses is well tolerated. High doses may cause enlargement of the liver , dry skin, and hypervitaminosis A . High doses during pregnancy may harm the fetus. The body converts retinol to retinal and retinoic acid , through which it acts. Retinol

2970-406: Is then attacked by water creating two hydroxyl groups in the center of the structure. The cleavage occurs when these alcohols are oxidized to the aldehydes using NADH . This compound is called retinal. Retinal is then reduced to retinol by the enzyme retinol dehydrogenase . Retinol dehydrogenase is an enzyme that is dependent on NADH. Retinol is made industrially via total synthesis using either

3060-549: Is typically reported in Arctic explorers and people taking large doses of synthetic vitamin A. The first documented death possibly caused by vitamin A poisoning was that of Xavier Mertz , a Swiss scientist, who died in January 1913 on an Antarctic expedition that had lost its food supplies and fell to eating its sled dogs. Mertz may have consumed lethal amounts of vitamin A by eating the dogs' livers. Vitamin A acute toxicity occurs when

3150-501: Is unique to each individual compound, however 1 IU of retinol is equivalent to approximately 0.3 micrograms (300 nanograms). This vitamin plays an essential role in vision, particularly night vision, normal bone and tooth development, reproduction, and the health of skin and mucous membranes (the mucus-secreting layer that lines body regions such as the respiratory tract). While Vitamin A is often considered to be an antioxidant that prevents cancers, it does not have antioxidant activity and

3240-533: Is used in differentiation of stem cells to more committed fates, echoing retinoic acid's importance in natural embryonic developmental pathways. It is thought to initiate differentiation into a number of different cell lineages through activation of the Retinoic acid receptor . It has numerous applications in the experimental induction of stem cell differentiation; amongst these are the differentiation of human embryonic stem cells to posterior foregut lineages. Retinol

3330-600: The International Organization for Standardization and regulated by national or regional regulations such as those issued by the EU or the FDA . Marketers and manufacturers of cosmetic products must be compliant to these regulations to be able to market their cosmetic products in the corresponding areas of jurisdiction . The manufacture of cosmetics is dominated by a small number of multinational corporations that originated in

3420-415: The innate immune response and maintains homeostasis of epithelial tissues and mucosa through its metabolite, retinoic acid (RA). As part of the innate immune system, toll-like receptors in skin cells respond to pathogens and cell damage by inducing a pro-inflammatory immune response which includes increased RA production. The epithelium of the skin encounters bacteria, fungi and viruses. Keratinocytes of

3510-490: The opsin protein (either rod opsin or blue, red or green cone opsins). The process of vision relies on the light-induced isomerisation of the chromophore from 11- cis to all- trans resulting in a change of the conformation and activation of the photoreceptor molecule. Many of the non-visual functions of vitamin A are mediated by retinoic acid, which regulates gene expression by activating nuclear retinoic acid receptors . The non-visual functions of vitamin A are essential in

3600-438: The vitamin A family that is found in food and used as a dietary supplement . Retinol or other forms of vitamin A are needed for vision, cellular development, maintenance of skin and mucous membranes , immune function and reproductive development. Dietary sources include fish, dairy products , and meat. As a supplement it is used to treat and prevent vitamin A deficiency , especially that which results in xerophthalmia . It

3690-571: The 20th century, the popularity of cosmetics increased rapidly. Cosmetics are used by girls at increasingly young ages, especially in the United States. Because of the fast-decreasing age of makeup users, many companies, from drugstore brands like Rimmel to higher-end products like Estee Lauder, cater to this expanding market by introducing flavored lipsticks and glosses, cosmetics packaged in glittery and sparkly packaging, and marketing and advertising using young models . The social consequences of younger and younger cosmetics use have had much attention in

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3780-482: The 21st century. The wider acceptance of the use of cosmetics led some to see makeup as a tool used in the oppression and subjection of women to unfair societal standards. In 1968, at the feminist Miss America protest , protesters symbolically threw a number of feminine products into a "Freedom Trash Can", with cosmetics among the items the protesters called "instruments of female torture" and accoutrements of what they perceived to be enforced femininity . As of 2016 ,

3870-590: The French federation for the perfume industry). France is another country in which the cosmetic industry plays an important role, both nationally and internationally. According to data from 2008, the cosmetic industry has grown constantly in France for 40 consecutive years. In 2006, this industrial sector reached a record level of €6.5 billion. Famous cosmetic brands produced in France include Vichy, Yves Saint Laurent , Yves Rocher , and many others. The Italian cosmetic industry

3960-590: The German cosmetic industry the third largest in the world, after Japan and the United States. German exports of cosmetics reached €5.8 billion in 2008, whereas imports of cosmetics totaled €3 billion. The worldwide cosmetics and perfume industry currently generates an estimated annual turnover of US$ 170 billion (according to Eurostaf, May 2007). Europe is the leading market, representing approximately €63 billion, while sales in France reached €6.5 billion in 2006, according to FIPAR (Fédération des Industries de la Parfumerie –

4050-458: The US was developed by figures such as Elizabeth Arden , Helena Rubinstein , and Max Factor . These firms were joined by Revlon just before World War II and Estée Lauder just after. By the middle of the 20th century, cosmetics were in widespread use by women in nearly all industrial societies around the world, with the cosmetics industry becoming a multibillion-dollar enterprise by the beginning of

4140-437: The United States has weakened over the years, with the number of men using makeup increasing in the 21st century. Cosmetics brands have increasingly targeted men in the sale of cosmetics, with some products targeted specifically at men . Lead has been used as a makeup product since the 18th century. It is said to be lethal to women who apply it daily to achieve a pale complexion representing nobility, as tanner skin represents

4230-516: The absence of regulation of the manufacture and use of cosmetics, as well as the absence of scientific knowledge regarding the effects of various compounds on the human body for much of this time period, led to a number of negative effects upon those who used cosmetics, including deformities , blindness, and, in some cases, death. Although harmless products were used, such as berries, and beetroot , many cosmetic products available at this time were still chemically dubious and even poisonous. Examples of

4320-404: The all- trans configuration (as seen in the structure of all- trans -retinol shown at the top of this page). Nevertheless, some cis isomers are found naturally and carry out essential functions. For example, the 11- cis -retinal isomer is the chromophore of rhodopsin , the vertebrate photoreceptor molecule. Rhodopsin is composed of the 11-cis-retinal covalently linked via a Schiff base to

4410-500: The appearance and "care" cosmetics designed for skincare and personal care. Most cosmetics are also distinguished by the area of the body intended for application, with cosmetics designed to be used on the face and eye area usually applied with a brush, a makeup sponge, or the fingertips. Cosmetics can also be described by the physical composition of the product. Cosmetics can be liquid or cream emulsions , powders (pressed or loose), dispersions, or anhydrous creams or sticks. Cleansing

4500-447: The appearance of fine lines on the face and neck. Vitamin A may be needed for normal red blood cell formation ; deficiency causes abnormalities in iron metabolism . Vitamin A is needed to produce the red blood cells from stem cells through retinoid differentiation. When referring to dietary allowances or nutritional science, retinol is usually measured in international units (IU). IU refers to biological activity and therefore

4590-425: The body (on the skin, particularly the hands and nails), and to the hair. These products may be intended for use as skincare, personal care, or to alter the appearance, with the subset of cosmetics known as makeup primarily referring to products containing colour pigments intended for the purpose of altering the wearer's appearance; some manufacturers will distinguish only between "decorative" cosmetics intended to alter

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4680-463: The brands of foundations, and 62% of liquid lipstick. PFAS compounds are readily absorbed through human skin and through tear ducts , and such products on lips are often unwittingly ingested. Manufacturers often fail to label their products as containing PFAS, which makes it difficult for cosmetics consumers to avoid products containing PFAS. Formaldehyde is no longer used in cosmetics but has been replaced by formaldehyde releasers . Formaldehyde

4770-428: The company Hoffmann-La Roche in 1947. In the following decades, eight other companies developed their own processes. β-ionone, synthesized from acetone, is the essential starting point for all industrial syntheses. Each process involves elongating the unsaturated carbon chain. Pure retinol is extremely sensitive to oxidization and is prepared and transported at low temperatures and oxygen-free atmospheres. When prepared as

4860-636: The conversion of carotenoids or retinyl esters into vitamin A is downregulated when physiological requirements are met; but excessive uptake of carotenoids can cause carotenosis . Excess preformed vitamin A during early pregnancy is associated with a significant increase in birth defects. These defects may be severe, even life-threatening. Even twice the daily recommended amount can cause severe birth defects. The FDA recommends that pregnant women get their vitamin A from foods containing beta carotene and that they ensure that they consume no more than 5,000 IU of preformed vitamin A (if any) per day. Although vitamin A

4950-483: The cosmetic industry came up with perfumes bearing their names. Moreover, some actors and singers (such as Celine Dion ) have their own perfume line. Designer perfumes are, like any other designer products, the most expensive in the industry as the consumer pays for the product and the brand. Famous Italian fragrances are produced by Giorgio Armani , Dolce & Gabbana , and others. Procter & Gamble , which sells CoverGirl and Dolce & Gabbana makeup, funded

5040-432: The cosmetic product. Secondary packaging is the outer wrapping of one or several cosmetic container(s). An important difference between primary and secondary packaging is that any information that is necessary to clarify the safety of the product must appear on the primary package. Otherwise, much of the required information can appear on just the secondary packaging. Cosmetic packaging is standardized by ISO 22715 , set by

5130-593: The cosmetics and hair dyes. The cosmetic companies do not have to report any injuries from the products; they also only have voluntary recalls of products. There has been a marketing trend towards the sale of cosmetics lacking controversial ingredients, especially those derived from petroleum , sodium lauryl sulfate (SLS), and parabens . Per- and polyfluoroalkyl substances (PFAS) are a class of about 9,000 synthetic organofluorine compounds that have multiple highly toxic fluorine atoms attached to an alkyl chain . PFAS are used by major cosmetics industry companies in

5220-489: The decades Garnier expanded from hair color and hair care into skincare since acquisition in 1970. In the 2000s, Garnier launched a line of hair color products, including permanent and semi-permanent dyes. Garnier demonstrated concern about the diversity of skin tones in its products. In 2021, the brand launched a line of products aimed at black skin in Brazil. The product was co-created by the brand with Brazilian singer Iza and

5310-449: The early 20th century, but the distribution and sales of cosmetics are spread among a wide range of businesses. The world's largest cosmetic companies are L'Oréal , Procter & Gamble , Unilever , Shiseido , and Estée Lauder . In 2005, the market volume of the cosmetics industry in the US, Europe, and Japan was about EUR 70 Billion/a year. In Germany, the cosmetic industry generated €12.6 billion of retail sales in 2008, which makes

5400-430: The epidermal layer of the skin produce and secrete antimicrobial peptides (AMPs). Production of AMPs resistin and cathelicidin , are promoted by RA. Another way that vitamin A helps maintain a healthy skin and hair follicle microbiome , especially on the face, is by reduction of sebum secretion, which is a nutrient source for bacteria. Retinol has been the subject of clinical studies related to its ability to reduce

5490-465: The eyes, weakened tooth enamel, and blackened skin, with heavy use known to lead to death. Usage of white lead was not confined only to the West, with the white Japanese face makeup known as oshiroi also produced using white lead. In the second part of the 19th century, scientific advances in the production of makeup lead to the creation of makeup free of hazardous substances such as lead . Throughout

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5580-545: The face in a circular motion. Gels, creams, or lotions may contain an acid to encourage dead skin cells to loosen, and an abrasive such as microbeads , sea salt and sugar, ground nut shells, rice bran, or ground apricot kernels to scrub the dead cells off the skin. Salt and sugar scrubs tend to be the harshest, while scrubs containing beads or rice bran are typically very gentle. A variety of organic compounds and inorganic compounds comprise typical cosmetics. Typical organic compounds are modified natural oils and fats as well as

5670-504: The generation alpha (the cohort born roughly between 2010 and 2025) and is growing up in a very different environment compared to previous generations, and several factors contribute to their heightened interest in skincare and makeup. Platforms like TikTok have also popularized short, fun videos about skincare and makeup tips, making beauty routines seem exciting and achievable. Social media platforms have made it easier for celebrities and influencers to become role models for Gen Alpha, and as

5760-413: The growth and development of embryos. During development, there is a concentration gradient of retinoic acid along the anterior-posterior (head-tail) axis. Cells in the embryo respond to retinoic acid differently depending on the amount present. For example, in vertebrates, the hindbrain transiently forms eight rhombomeres and each rhombomere has a specific pattern of genes being expressed. If retinoic acid

5850-453: The human body for cleansing, beautifying, promoting attractiveness, or altering the appearance without affecting the body's structure or functions." This broad definition includes any material intended for use as an ingredient in a cosmetic product, with the FDA specifically excluding pure soap from this category. Cosmetics designed for skin care may be used to cleanse, exfoliate and protect

5940-423: The immunological function, reproduction and embryonic development of vertebrates as evidenced by the impaired growth, susceptibility to infection and birth defects observed in populations receiving suboptimal vitamin A in their diet. Retinol is synthesized from the breakdown of β-carotene . First, the β-carotene 15,15'-monooxygenase cleaves β-carotene at the central double bond, creating an epoxide . This epoxide

6030-412: The late 19th and early 20th centuries, changes in the prevailing attitudes towards cosmetics led to a wider expansion of the cosmetics industry. In 1882, English actress and socialite Lillie Langtry became the poster girl for Pears of London, making her the first celebrity to endorse a commercial product. She allowed her name to be used on face powders and skin products. During the 1910s, the market in

6120-533: The legal definition of cosmetics in most countries is broader, in some Western countries , cosmetics are commonly taken to mean only makeup products, such as lipstick , mascara , eye shadow , foundation , blush , highlighter , bronzer , fake eyelashes , eyeliner , concealer , lip gloss , and several other product types. In the United States, the Food and Drug Administration (FDA), which regulates cosmetics, defines cosmetics as products "intended to be applied to

6210-528: The likes of Boots and Sephora. This is most commonly reported in western countries, specifically America, Australia and the United Kingdom. This has garnered attention because it bring awareness to the growing need for make-up for younger girls and women, many criticize this claiming it's connected to western beauty standards which in recent years have become an increasingly controversial topic in many medias revolving around politics and women's rights. It's also

6300-473: The major share of industrial production. In 1912, Frederick Gowland Hopkins demonstrated that unknown accessory factors found in milk, other than carbohydrates , proteins , and fats were necessary for growth in rats. Hopkins received a Nobel Prize for this discovery in 1929. One year later, Elmer McCollum , a biochemist at the University of Wisconsin–Madison , and colleague Marguerite Davis identified

6390-586: The media over the last few years. Criticism of cosmetics has come from a wide variety of sources including some feminists , religious groups , animal rights activists , authors , and public interest groups. It has also faced criticism from men, some of whom describe it as a form of deception or fakeup . The new generation has been more accepting of males wearing makeup, and having a "soft pretty boy" look in South Korea has become more widespread in recent years, particularly among younger generations. This trend

6480-517: The more light-sensitive and abundant rods , which have rhodopsin , have impaired sensitivity, and the cone cells are less affected. The cones are less abundant than rods and come in three types, each contains its own type of iodopsin , the opsins of the cones. The cones mediate color vision , and vision in bright light (day vision). Glycoprotein synthesis requires adequate vitamin A status. In severe vitamin A deficiency, lack of glycoproteins may lead to corneal ulcers or liquefaction. Vitamin A

6570-480: The most common cosmetic products exported to the United States. According to Euromonitor International, the market for cosmetics in China is expected to be $ 7.4 billion in 2021 up from $ 4.3 billion in 2016. The increase is due to social media and the changing attitudes of people in the 18-to-30-year age bracket. Due to the popularity of cosmetics, especially fragrances, many designers who are not necessarily involved in

6660-463: The most well-known being β-carotene. For this reason, amounts of vitamin A are measured in Retinol Equivalents (RE). One RE is equivalent to 0.001 mg of retinol, or 0.006 mg of β-carotene, or 3.3 International Units of vitamin A. Vitamin A is fat-soluble and is stored in the liver and fat tissue. When required by a particular part of the body, the liver releases some vitamin A, which

6750-478: The necessary form needed for rhodopsin. Retinoids are found naturally only in foods of animal origin. Each of the following contains at least 0.15 mg of retinoids per 1.75–7 oz (50–198 g): Many different geometric isomers of retinol, retinal and retinoic acid are possible as a result of either a trans or cis configuration of four of the five double bonds found in the polyene chain. The cis isomers are less stable and can readily convert to

6840-434: The neurons growing in that region behave like neurons from rhombomere 2. Retinoic acid is not required for patterning of the retina as originally proposed, but retinoic acid synthesized in the retina is secreted into surrounding mesenchyme where it is required to prevent overgrowth of perioptic mesenchyme which can cause microphthalmia, defects in the cornea and eyelid, and rotation of the optic cup. Synthetic retinoic acid

6930-478: The prevalent usage of harmful cosmetics include the use of ceruse (white lead) throughout a number of different cultures, such as during the Renaissance in the West, and blindness caused by the mascara Lash Lure during the early 20th century. During the 19th century, there were numerous incidents of lead poisoning due to the fashion for red and white lead makeup and powder, leading to swelling and inflammation of

7020-624: The role of retinol and retinoic acid in increasing circulating cholesterol and triglycerides as well as promoting cancer incidence. Studies emerging from developing countries India, Bangladesh, and Indonesia strongly suggest that, in populations in which vitamin A deficiency is common and maternal mortality is high, dosing expectant mothers with retinol can greatly reduce maternal mortality. Similarly, dosing newborn infants with 50,000 IU (15 mg) of vitamin A within two days of birth can significantly reduce neonatal mortality. Retinol or other forms of vitamin A are needed for eyesight, maintenance of

7110-474: The same primary ingredients as dry mineral makeups. Liquid makeups must contain preservatives, and compressed makeups must contain binders, which dry mineral makeups do not. Mineral makeup usually does not contain synthetic fragrances, preservatives, parabens, mineral oil, or chemical dyes. For this reason, dermatologists may consider mineral makeup to be gentler on the skin than makeup that contains those ingredients. Some minerals are nacreous or pearlescent, giving

7200-414: The skin a shining or sparking appearance. One example is bismuth oxychloride . There are various mineral-based makeup brands, including: Bare Minerals, Tarte , Bobbi Brown , and Stila . The term cosmetic packaging is used for primary packaging and secondary packaging of cosmetic products. Primary packaging, also called cosmetic containers, houses the cosmetic product. It is in direct contact with

7290-435: The skin, and human development. Other than for vision, which requires 11-cis retinal, the active compound is retinoic acid, synthesized from retinal, in turn synthesized from retinol. The differing biological roles of retinoic acid depend on its stereochemistry and whether it is present in the all-trans, 9-cis or 13-cis forms. Retinoic acid via the retinoic acid receptor influences the process of cell differentiation, hence,

7380-403: The skin, as well as replenish it, using body lotions , cleansers , toners , serums, moisturizers , eye creams, retinol , and balms. Cosmetics designed for more general personal care , such as shampoo , soap, and body wash , can be used to clean the body. Cosmetics designed to enhance one's appearance (makeup) can be used to conceal blemishes, enhance one's natural features, or add color to

7470-724: The skin. The FDA , which regulates the US cosmetic industry, says "FDA has not defined the term “natural” and has not established a regulatory definition for this term in cosmetic labeling." It goes on to warn consumers, "choosing ingredients from sources you consider “organic” or “natural” is no guarantee that they are safe." The term "mineral makeup" applies to a category of face makeup, including foundation, eye shadow, blush, and bronzer, made with loose, dry mineral powders. These powders are often mixed with oil-water emulsions . Lipsticks, liquid foundations, and other liquid cosmetics, as well as compressed makeups such as eye shadow and blush in compacts, are often called mineral makeup if they have

7560-527: The source of the vitamin A is known. The IU values listed above do not apply to food sources of vitamin A. Too much vitamin A in retinoid form can be harmful. The body converts the dimerized form, carotene , into vitamin A as it is needed, so high levels of carotene are not toxic, whereas the ester (animal) forms are. The livers of certain animals, especially those adapted to polar environments, such as polar bears and seals, often contain amounts of vitamin A that would be toxic to humans. Thus, vitamin A toxicity

7650-579: The use of cosmetics continued into the Middle Ages —where the face was whitened and the cheeks rouged— though attitudes towards cosmetics varied throughout time, with the use of cosmetics being openly frowned upon at many points in Western history. Regardless of the changes in social attitudes towards cosmetics, many occasionally achieved ideals of appearance through cosmetics. According to one source, early major developments in cosmetics include: Historically,

7740-404: The working class. Lead can be detrimental to people's health and cause death if mixed with vinegar which it allows lead to be absorbed through the skin. Though there are a large number of different cosmetics used for a variety of different purposes, all cosmetics are typically intended to be applied externally. These products can be applied to the face (on the skin, lips, eyebrows, and eyes), to

7830-537: The world have stringent regulations for cosmetics. In the United States, cosmetic products and ingredients do not require FDA approval. Some countries have banned using animals for cosmetic testing. The word cosmetics is derived from the Greek κοσμητικὴ τέχνη ( kosmetikē tekhnē ), meaning "technique of dress and ornament," from κοσμητικός ( kosmētikos ), "skilled in ordering or arranging," and from κόσμος ( kosmos ), meaning "order" and "ornament.". Though

7920-540: The world's largest cosmetics company is L'Oréal , founded by Eugène Schueller in 1909 as the French Harmless Hair Colouring Company (now owned by Liliane Bettencourt 26% and Nestlé 28%; the remaining 46% is traded publicly). Although modern makeup has been traditionally used mainly by women, men also use makeup to enhance their own facial features or cover blemishes and dark circles. The negative stigma of men wearing makeup in countries such as

8010-518: Was a co-recipient of the Nobel Prize in Physiology and Medicine "..."for their discoveries concerning the primary physiological and chemical visual processes in the eye." Photoreceptor cells in the eye contain a chromophore composed of the protein opsin and 11-cis retinal . When struck by light, 11-cis retinal undergoes photoisomerization to all-trans retinal and via signal transduction cascade send

8100-547: Was discovered in 1909, isolated in 1931, and first made in 1947. It is on the World Health Organization's List of Essential Medicines . Retinol is available as a generic medication and over the counter . In 2021, vitamin A was the 298th most commonly prescribed medication in the United States, with more than 500,000 prescriptions. Retinol is used to treat vitamin A deficiency . Three approaches may be used when populations have low vitamin A levels: Retinol

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