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138-619: The Dharug or Darug people, are an Aboriginal Australian people, who share ties of kinship and, in pre-colonial times, lived as hunters in family groups or clans, scattered throughout much of what is modern-day Sydney . The Dharug were bounded by the Awabakal to the north of Broken Bay, the Darkinjung to the northwest, the Wiradjuri to the west on the eastern fringe of the Blue Mountains ,

276-587: A Holocene hunter-gatherer sample ("Leang Panninge") from South Sulawesi , which shares high amounts of genetic drift with Aboriginal Australians and Papuans. This suggests that a population split from the common ancestor of Aboriginal Australians and Papuans. The sample also shows genetic affinity with East Asians and the Andamanese people of South Asia. The authors note that this hunter-gatherer sample can be modelled with ~50% Papuan-related ancestry and either with ~50% East Asian or Andamanese Onge ancestry, highlighting

414-410: A marker gene . This gene, called GFP , or green fluorescent protein, would cause live samples of the virus to glow green under fluorescent light. The insertion of this gene, which would not influence the virulence of the virus, would be the only allowed modification of the genome. The committee stated the proposed modification would aid in research of treatments by making it easier to assess whether

552-443: A clinical case was observed, smallpox was confirmed using laboratory tests. Microscopically , poxviruses produce characteristic cytoplasmic inclusion bodies , the most important of which are known as Guarnieri bodies , and are the sites of viral replication . Guarnieri bodies are readily identified in skin biopsies stained with hematoxylin and eosin, and appear as pink blobs. They are found in virtually all poxvirus infections but

690-415: A discrete rash, in which the pustules stood out on the skin separately. The distribution of the rash was most dense on the face, denser on the extremities than on the trunk, and denser on the distal parts of the extremities than on the proximal. The palms of the hands and soles of the feet were involved in most cases. Sometimes, the blisters merged into sheets, forming a confluent rash, which began to detach

828-513: A doctor in Berkeley, Gloucestershire , rural England, discovered that immunity to smallpox could be produced by inoculating a person with material from a cowpox lesion. Cowpox is a poxvirus in the same family as variola. Jenner called the material used for inoculation vaccine from the root word vacca , which is Latin for cow. The procedure was much safer than variolation and did not involve a risk of smallpox transmission. Vaccination to prevent smallpox

966-451: A fatality rate of around 30%, while variola minor’s mortality rate was about 1%. Throughout the 18th century, variola major was responsible for around 400,000 deaths annually in Europe alone. Survivors of the disease often faced lifelong consequences, such as blindness and severe scarring, which were nearly universal among those who recovered. In the first half of the 20th century, variola major

1104-593: A gene flow from India to Australia: firstly, signs of South Asian components in Aboriginal Australian genomes, reported on the basis of genome-wide SNP data; and secondly, the existence of a Y chromosome (male) lineage, designated haplogroup C∗, with the most recent common ancestor about 5,000 years ago. The first type of evidence comes from a 2013 study by the Max Planck Institute for Evolutionary Anthropology using large-scale genotyping data from

1242-614: A host cell varies across the poxviridae . Recombination of the genome occurs within actively infected cells. Following the onset of viral DNA replication, an intermediate set of genes codes for transcription factors of late gene expression. The products of the later genes include transcription factors necessary for transcribing the early genes for new virions, as well as viral RNA polymerase and other essential enzymes for new viral particles. These proteins are then packaged into new infectious virions capable of infecting other cells. Two live samples of variola major virus remain, one in

1380-408: A more extensive rash and higher fever. Variola minor is a less common presentation, causing less severe disease, typically discrete smallpox, with historical death rates of 1% or less. Subclinical ( asymptomatic ) infections with variola virus were noted but were not common. In addition, a form called variola sine eruptione (smallpox without rash) was seen generally in vaccinated persons. This form

1518-475: A number of woodland clans who each tended to live in a certain geographic area. This area would also house descendant clans. Each clan typically included 50 to 100 people. According to James Kohen, the clans numbered 15, but more accurate records highlight 29 clans: By the late 1790s , the Hawkesbury River area was claimed by more than 400 British settlers. The farms made by the settlers were barriers to

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1656-731: A person as Indigenous. (Torres Strait Islanders are ethnically and culturally distinct, despite extensive cultural exchange with some of the Aboriginal groups, and the Torres Strait Islands are mostly part of Queensland but have a separate governmental status .) Some Aboriginal people object to being labelled Indigenous , as an artificial and denialist term, because some non-Aboriginal people have referred to themselves as indigenous because they were born in Australia. Australian Indigenous people have beliefs unique to each mob ( tribe ) and have

1794-588: A pool of Aboriginal Australians, New Guineans, island Southeast Asians, and Indians. It found that the New Guinea and Mamanwa (Philippines area) groups diverged from the Aboriginal about 36,000 years ago (there is supporting evidence that these populations are descended from migrants taking an early "southern route" out of Africa, before other groups in the area). Also the Indian and Australian populations mixed long before European contact, with this gene flow occurring during

1932-587: A potential treatment was effective in killing viral samples. The recommendation could only take effect if approved by the WHA . When the WHA discussed the proposal in 2005, it refrained from taking a formal vote on the proposal, stating that it would review individual research proposals one at a time. Addition of the GFP gene to the Vaccinia genome is routinely performed during research on

2070-615: A profound spiritual connection. Over the millennia, Aboriginal people developed complex trade networks, inter-cultural relationships, law and religions. Contemporary Aboriginal beliefs are a complex mixture, varying by region and individual across the continent. They are shaped by traditional beliefs, the disruption of colonisation, religions brought to the continent by Europeans, and contemporary issues. Traditional cultural beliefs are passed down and shared through dancing , stories , songlines , and art that collectively weave an ontology of modern daily life and ancient creation known as

2208-423: A region of roughly 100 base pairs necessary for resolving concatomeric DNA (a stretch of DNA containing multiple copies of the same sequence), a few open reading frames , and short tandemly repeating sequences of varying number and length. The ITRs of poxviridae vary in length across strains and species. The coding sequence for most of the viral proteins in variola major virus have at least 90% similarity with

2346-483: A single group. Aboriginal identity has changed over time and place, with family lineage, self-identification, and community acceptance all of varying importance. In the 2021 census , Indigenous Australians comprised 3.8% of Australia's population. Most Aboriginal people today speak English and live in cities. Some may use Aboriginal phrases and words in Australian Aboriginal English (which also has

2484-421: A source of infection”; noted that “Current recommendations for control of secondary smallpox infections emphasize transmission ‘by expelled droplets to close contacts (those within 6–7 feet)’”; but warned that the “emphasis on spread via large droplets may reduce the vigilance with which more difficult airborne precautions [i.e. against finer droplets capable of traveling longer distances and penetrating deeply into

2622-411: A spirit creates the earth then tells the humans to treat the animals and the earth in a way which is respectful to land. In Northern Territory this is commonly said to be a huge snake or snakes that weaved its way through the earth and sky making the mountains and oceans. But in other places the spirits who created the world are known as wandjina rain and water spirits. Major ancestral spirits include

2760-470: A strong connection to the land. Contemporary Indigenous Australian beliefs are a complex mixture, varying by region and individual across the continent. They are shaped by traditional beliefs, the disruption of colonisation, religions brought to the continent by Europeans, and contemporary issues. Traditional cultural beliefs are passed down and shared by dancing , stories , songlines and art —especially Papunya Tula (dot painting)—collectively telling

2898-427: A tangible influence of Aboriginal languages in the phonology and grammatical structure ). Many but not all also speak the various traditional languages of their clans and peoples. Aboriginal people, along with Torres Strait Islander people, have a number of severe health and economic deprivations in comparison with the wider Australian community. DNA studies have confirmed that "Aboriginal Australians are one of

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3036-582: Is a severe form accompanied by extensive bleeding into the skin, mucous membranes, gastrointestinal tract, and viscera . This form develops in approximately 2% of infections and occurs mostly in adults. Pustules do not typically form in hemorrhagic smallpox. Instead, bleeding occurs under the skin, making it look charred and black, hence this form of the disease is also referred to as variola nigra or "black pox". Hemorrhagic smallpox has very rarely been caused by variola minor virus. While bleeding may occur in mild cases and not affect outcomes, hemorrhagic smallpox

3174-420: Is also a later form of hemorrhagic smallpox (referred to late hemorrhagic smallpox, or variolosa pustula hemorrhagica ). The prodrome is severe and similar to that observed in early hemorrhagic smallpox, and the fever persists throughout the course of the disease. Bleeding appears in the early eruptive period (but later than that seen in purpura variolosa ), and the rash is often flat and does not progress beyond

3312-486: Is also under research as a viral vector for vaccines for unrelated diseases. The genome of variola major virus was first sequenced in its entirety in the 1990s. The complete coding sequence is publicly available online. The current reference sequence for variola major virus was sequenced from a strain that circulated in India in 1967. In addition, there are sequences for samples of other strains that were collected during

3450-750: Is an increase in allele sharing between the Denisovan and Aboriginal Australian genomes, compared to other Eurasians or Africans. Examining DNA from a finger bone excavated in Siberia , researchers concluded that the Denisovans migrated from Siberia to tropical parts of Asia and that they interbred with modern humans in Southeast Asia 44,000 years BP, before Australia separated from New Guinea approximately 11,700 years BP. They contributed DNA to Aboriginal Australians and to present-day New Guineans and an indigenous tribe in

3588-471: Is based on the Aboriginal peoples' geographical isolation, with little or no interaction with outside cultures before some contact with Makassan fishermen and Dutch explorers up to 500 years ago. The Rasmussen study also found evidence that Aboriginal peoples carry some genes associated with the Denisovans (a species of human related to but distinct from Neanderthals ) of Asia; the study suggests that there

3726-541: Is believed to have had a mortality rate of less than 1%, as compared to variola major's 30%. Like variola major, variola minor was spread through inhalation of the virus in the air, which could occur through face-to-face contact or through fomites. Infection with variola minor virus conferred immunity against the more dangerous variola major virus. Because variola minor was a less debilitating disease than smallpox, people were more frequently ambulant and thus able to infect others more rapidly. As such, variola minor swept through

3864-411: Is caused by infection with variola virus, which belongs to the family Poxviridae , subfamily Chordopoxvirinae , genus Orthopoxvirus . The date of the appearance of smallpox is not settled. It most probably evolved from a terrestrial African rodent virus between 68,000 and 16,000 years ago. The wide range of dates is due to the different records used to calibrate the molecular clock . One clade

4002-488: Is complicated by having multiple infectious forms, with differing mechanisms of cell entry. Poxviruses are unique among human DNA viruses in that they replicate in the cytoplasm of the cell rather than in the nucleus . To replicate, poxviruses produce a variety of specialized proteins not produced by other DNA viruses , the most important of which is a viral-associated DNA-dependent RNA polymerase . Both enveloped and unenveloped virions are infectious. The viral envelope

4140-447: Is consistent with the other published estimates, it suggests that the archaeological and historical evidence is very incomplete. Better estimates of mutation rates in these viruses are needed. Examination of a strain that dates from c.  1650 found that this strain was basal to the other presently sequenced strains. The mutation rate of this virus is well modeled by a molecular clock. Diversification of strains only occurred in

4278-550: Is estimated to have killed up to 300 million people in the 20th century and around 500 million people in the last 100 years of its existence. Earlier deaths included six European monarchs , including Louis XV of France in 1774. As recently as 1967, 15 million cases occurred a year. The final known fatal case occurred in the United Kingdom in 1978 . Inoculation for smallpox appears to have started in China around

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4416-415: Is made of modified Golgi membranes containing viral-specific polypeptides, including hemagglutinin . Infection with either variola major virus or variola minor virus confers immunity against the other. The more common, infectious form of the disease was caused by the variola major virus strain, known for its significantly higher mortality rate compared to its counterpart, variola minor. Variola major had

4554-480: Is no evidence for South Asian gene flow to Australia .... Despite Sahul being a single connected landmass until [8,000 years ago], different groups across Australia are nearly equally related to Papuans, and vice versa, and the two appear to have separated genetically already [about 30,000 years ago]." Aboriginal Australians possess inherited abilities to adapt to a wide range of environmental temperatures in various ways. A study in 1958 comparing cold adaptation in

4692-453: Is only in the last two hundred years that they have been defined and started to self-identify as a single group, socio-politically. While some preferred the term Aborigine to Aboriginal in the past, as the latter was seen to have more directly discriminatory legal origins, use of the term Aborigine has declined in recent decades, as many consider the term an offensive and racist hangover from Australia's colonial era. The definition of

4830-493: Is rapidly followed by the development of petechiae and bleeding in the skin, conjunctiva and mucous membranes. Death often occurs suddenly between the fifth and seventh days of illness, when only a few insignificant skin lesions are present. Some people survive a few days longer, during which time the skin detaches and fluid accumulates under it, rupturing at the slightest injury. People are usually conscious until death or shortly before. Autopsy reveals petechiae and bleeding in

4968-497: Is that the desert people are able to have a higher body temperature without accelerating the activity of the whole of the body, which can be especially detrimental in childhood diseases. This helps protect people to survive the side-effects of infection. Aboriginal people have lived for tens of thousands of years on the continent of Australia , through its various changes in landmass. The area within Australia 's borders today includes

5106-453: Is typically fatal. Vaccination does not appear to provide any immunity to either form of hemorrhagic smallpox and some cases even occurred among people that were revaccinated shortly before. It has two forms. The early or fulminant form of hemorrhagic smallpox (referred to as purpura variolosa ) begins with a prodromal phase characterized by a high fever, severe headache, and abdominal pain. The skin becomes dusky and erythematous, and this

5244-623: The CC BY 4.0 license. Smallpox Smallpox was an infectious disease caused by variola virus (often called smallpox virus), which belongs to the genus Orthopoxvirus . The last naturally occurring case was diagnosed in October 1977, and the World Health Organization (WHO) certified the global eradication of the disease in 1980, making smallpox the only human disease to have been eradicated to date. The initial symptoms of

5382-486: The CSIRO stressed the importance of taking a demand-driven approach to services in desert settlements, and concluded that "if top-down solutions continue to be imposed without appreciating the fundamental drivers of settlement in desert regions, then those solutions will continue to be partial, and ineffective in the long term." [REDACTED]  This article incorporates text by Anders Bergström et al. available under

5520-674: The East India Company stationed in China and another by Clopton Havers . Lady Mary Wortley Montagu observed smallpox inoculation during her stay in the Ottoman Empire , writing detailed accounts of the practice in her letters, and enthusiastically promoted the procedure in England upon her return in 1718. According to Voltaire (1742), the Turks derived their use of inoculation from neighbouring Circassia . Voltaire does not speculate on where

5658-696: The Gandangara to the southwest in the Southern Highlands , and the Tharawal to the southeast in the Illawarra area. The Dharug language , now in a period of revitalization, is generally considered one of two dialects, inland and coastal, constituting a single language. The word myall , a pejorative word in Australian dialect denoting any Aboriginal person who kept up a traditional way of life, originally came from

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5796-478: The Georges River and shoot any Dharug on sight. The guerrilla was so effective that in 1816 Governor Macquarie forbade Aboriginals to carry any weapons within two kilometres of a house or a town or to congregate in groups bigger than six. He also authorised settlers to establish vigilante groups and the creation of three new military outposts. A group led by Pemulwuy made a daring raid on Parramatta , where he

5934-573: The Initial Upper Paleolithic . They are most closely related to other Oceanians , such as Melanesians . The Aboriginal Australians also show affinity to other Australasian populations, such as Negritos , as well as to East Asian peoples . Phylogenetic data suggests that an early initial eastern lineage (ENA) trifurcated somewhere in South Asia , and gave rise to Australasians (Oceanians), Ancient Ancestral South Indian (AASI), Andamanese and

6072-688: The Kimberley region in what is now Western Australia about 60,000 years ago. They migrated across the continent within 6,000 years. A 2018 study using archaeobotany dated evidence of continuous human habitation at Karnatukul (Serpent's Glen) in the Carnarvon Range in the Little Sandy Desert in WA from around 50,000 years ago. Genetic studies have revealed that Aboriginal Australians largely descended from an Eastern Eurasian population wave during

6210-657: The Northern Territory to study their genetic makeup (which is not representative of all Aboriginal peoples in Australia). The study concluded that the Warlpiri are descended from ancient Asians whose DNA is still somewhat present in Southeastern Asian groups, although greatly diminished. The Warlpiri DNA lacks certain information found in modern Asian genomes, and carries information not found in other genomes. This reinforces

6348-453: The Pleistocene epoch and lived over large sections of the Australian continental shelf when the sea levels were lower. At that time, Australia, Tasmania and New Guinea were part of the same landmass, known as Sahul . As sea levels rose, the people on the Australian mainland and nearby islands became increasingly isolated, some on Tasmania and some of the smaller offshore islands when

6486-611: The Rainbow Serpent , Baiame , Dirawong and Bunjil . Similarly, the Arrernte people of central Australia believed that humanity originated from great superhuman ancestors who brought the sun, wind and rain as a result of breaking through the surface of the Earth when waking from their slumber. Taken as a whole, Aboriginal Australians, along with Torres Strait Islander people, have a number of health and economic deprivations in comparison with

6624-422: The common cold : fever of at least 38.3 °C (101 °F), muscle pain , malaise , headache and fatigue. As the digestive tract was commonly involved, nausea, vomiting, and backache often occurred. The early prodromal stage usually lasted 2–4 days. By days 12–15, the first visible lesions – small reddish spots called enanthem – appeared on mucous membranes of the mouth, tongue, palate , and throat, and

6762-470: The horsepox virus using publicly available sequence data for horsepox. The researchers argued that their work would be beneficial to creating a safer and more effective vaccine for smallpox, although an effective vaccine is already available. The horsepox virus had previously seemed to have gone extinct, raising concern about potential revival of variola major and causing other scientists to question their motives. Critics found it especially concerning that

6900-468: The replication of viral DNA. The first set of expressed genes are transcribed by pre-existing viral machinery packaged within the infecting virion. These genes encode the factors necessary for viral DNA synthesis and for transcription of the next set of expressed genes. Unlike most DNA viruses, DNA replication in variola virus and other poxviruses takes place within the cytoplasm of the infected cell. The exact timing of DNA replication after infection of

7038-462: The 1500s. Europe adopted this practice from Asia in the first half of the 18th century. In 1796, Edward Jenner introduced the modern smallpox vaccine. In 1967, the WHO intensified efforts to eliminate the disease. Smallpox is one of two infectious diseases to have been eradicated, the other being rinderpest (a disease of even-toed ungulates ) in 2011. The term "smallpox" was first used in England in

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7176-409: The 16th century to distinguish the disease from syphilis , which was then known as the "great pox". Other historical names for the disease include pox, speckled monster, and red plague. The United States and Russia retain samples of variola virus in laboratories, which has sparked debates over safety . There are two forms of the smallpox. Variola major is the severe and most common form, with

7314-624: The 18th and 19th centuries. Variola virus is large and brick-shaped and is approximately 302 to 350 nanometers by 244 to 270 nm, with a single linear double stranded DNA genome 186 kilobase pairs (kbp) in size and containing a hairpin loop at each end. Four orthopoxviruses cause infection in humans: variola, vaccinia , cowpox , and monkeypox . Variola virus infects only humans in nature, although primates and other animals have been infected in an experimental setting. Vaccinia, cowpox, and monkeypox viruses can infect both humans and other animals in nature. The life cycle of poxviruses

7452-774: The 1970s and 1980s, when Aboriginal people moved to tiny remote settlements on traditional land, brought health benefits, but funding them proved expensive, training and employment opportunities were not provided in many cases, and support from governments dwindled in the 2000s, particularly in the era of the Howard government . Indigenous communities in remote Australia are often small, isolated towns with basic facilities, on traditionally owned land . These communities have between 20 and 300 inhabitants and are often closed to outsiders for cultural reasons. The long-term viability and resilience of Aboriginal communities in desert areas has been discussed by scholars and policy-makers. A 2007 report by

7590-655: The 19th century. Scholars believe that most Aboriginal Australians originated from Southeast Asia. If this is the case, Aboriginal Australians were among the first in the world to have completed sea voyages. A 2017 paper in Nature evaluated artefacts in Kakadu . Its authors concluded "Human occupation began around 65,000 years ago." A 2021 study by researchers at the Australian Research Council Centre of Excellence for Australian Biodiversity and Heritage has mapped

7728-752: The Circassians derived their technique from, though he reports that the Chinese have practiced it "these hundred years". In 1721, Cotton Mather and colleagues provoked controversy in Boston by inoculating hundreds. After publishing The present method of inoculating for the small-pox in 1767, Dr Thomas Dimsdale was invited to Russia to variolate the Empress Catherine the Great of Russia and her son, Grand Duke Paul , which he successfully did in 1768. In 1796, Edward Jenner ,

7866-467: The Dharug language term mayal , which denoted any person hailing from another tribe. Norman Tindale reckoned Dharug lands as encompassing 2,300 square miles (6,000 km), taking in the mouth of the Hawkesbury River , and running inland as far as Mount Victoria . It took in the areas around Campbelltown , Liverpool , Camden , Penrith and Windsor . Traditionally, there was a cultural divide between

8004-554: The Dharug people has been the "Blacks Town" (at the modern suburb of Colebee ) in the Blacktown local government area. However, in September 2012 the City of Blacktown decided to cease recognising the Dharug people as the traditional owners of the area. The council also passed a motion, opposed by some councillors, to begin a process to consider changing the name "Blacktown". An online petition

8142-491: The Dreaming . Studies of Aboriginal groups' genetic makeup are ongoing, but evidence suggests that they have genetic inheritance from ancient Asian but not more modern peoples. They share some similarities with Papuans , but have been isolated from Southeast Asia for a very long time. They have a broadly shared, complex genetic history, but only in the last 200 years were they defined by others as, and started to self-identify as,

8280-599: The East/Southeast Asian lineage, including ancestors of the Native Americans . Papuans may have received approximately 2% of their geneflow from an earlier group (xOOA) as well, next to additional archaic admixture in the Sahul region. Aboriginal people are genetically most similar to the indigenous populations of Papua New Guinea , and more distantly related to groups from East Indonesia. They are more distinct from

8418-864: The Holocene ( c. 4,200 years ago). The researchers had two theories for this: either some Indians had contact with people in Indonesia who eventually transferred those Indian genes to Aboriginal Australians, or a group of Indians migrated from India to Australia and intermingled with the locals directly. However, a 2016 study in Current Biology by Anders Bergström et al. excluded the Y chromosome as providing evidence for recent gene flow from India into Australia. The study authors sequenced 13 Aboriginal Australian Y chromosomes using recent advances in gene sequencing technology. They investigated their divergence times from Y chromosomes in other continents, including comparing

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8556-849: The Northern, Southern and Central cultural areas. The Northern and Southern areas, having richer natural marine and woodland resources, were more densely populated than the Central area. There are various other names from Australian Aboriginal languages commonly used to identify groups based on geography , known as demonyms , including: Other group names are based on the language group or specific dialect spoken . These also coincide with geographical regions of varying sizes. A few examples are: However, these lists are neither exhaustive nor definitive, and there are overlaps. Different approaches have been taken by non-Aboriginal scholars in trying to understand and define Aboriginal culture and societies, some focusing on

8694-759: The Philippines known as Mamanwa . This study confirms Aboriginal Australians as one of the oldest living populations in the world. They are possibly the oldest outside Africa, and they may have the oldest continuous culture on the planet. A 2016 study at the University of Cambridge suggests that it was about 50,000 years ago that these peoples reached Sahul (the supercontinent consisting of present-day Australia and its islands and New Guinea ). The sea levels rose and isolated Australia about 10,000 years ago, but Aboriginal Australians and Papuans diverged from each other genetically earlier, about 37,000 years BP, possibly because

8832-793: The United States at the CDC in Atlanta, and one at the Vector Institute in Koltsovo, Russia. Research with the remaining virus samples is tightly controlled, and each research proposal must be approved by the WHO and the World Health Assembly (WHA). Most research on poxviruses is performed using the closely related Vaccinia virus as a model organism. Vaccinia virus, which is used to vaccinate for smallpox,

8970-507: The United States, Great Britain, and South Africa in the early 20th century, becoming the dominant form of the disease in those areas and thus rapidly decreasing mortality rates. Along with variola major, the minor form has now been totally eradicated from the globe. The last case of indigenous variola minor was reported in a Somali cook, Ali Maow Maalin, in October 1977, and smallpox was officially declared eradicated worldwide in May 1980. Variola minor

9108-517: The WHO eradication campaign. A genome browser for a complete database of annotated sequences of variola virus and other poxviruses is publicly available through the Viral Bioinformatics Resource Center . The WHO currently bans genetic engineering of the variola virus. However, in 2004, a committee advisory to the WHO voted in favor of allowing editing of the genome of the two remaining samples of variola major virus to add

9246-507: The absence of Guarnieri bodies could not be used to rule out smallpox. The diagnosis of an orthopoxvirus infection can also be made rapidly by electron microscopic examination of pustular fluid or scabs. All orthopoxviruses exhibit identical brick-shaped virions by electron microscopy. If particles with the characteristic morphology of herpesviruses are seen this will eliminate smallpox and other orthopoxvirus infections. Definitive laboratory identification of variola virus involved growing

9384-444: The ancient people expanded and differentiated into distinct groups, each with its own language and culture. More than 400 distinct Australian Aboriginal peoples have been identified, distinguished by names designating their ancestral languages, dialects, or distinctive speech patterns. According to noted anthropologist , archaeologist and sociologist Harry Lourandos , historically, these groups lived in three main cultural areas,

9522-448: The bloodstream in large numbers, a condition known as viremia . This resulted in the second wave of multiplication in the spleen , bone marrow , and lymph nodes. The clinical definition of ordinary smallpox is an illness with acute onset of fever equal to or greater than 38.3 °C (101 °F) followed by a rash characterized by firm, deep-seated vesicles or pustules in the same stage of development without other apparent cause. When

9660-477: The central region of the genome is highly consistent across orthopoxviruses , and the arrangement of genes is consistent across chordopoxviruses. The center of the variola virus genome contains the majority of the essential viral genes, including the genes for structural proteins , DNA replication , transcription , and mRNA synthesis. The ends of the genome vary more across strains and species of orthopoxviruses . These regions contain proteins that modulate

9798-503: The closely related Vaccinia virus . The public availability of the variola virus complete sequence has raised concerns about the possibility of illicit synthesis of infectious virus. Vaccinia , a cousin of the variola virus, was artificially synthesized in 2002 by NIH scientists. They used a previously established method that involved using a recombinant viral genome to create a self-replicating bacterial plasmid that produced viral particles. In 2016, another group synthesized

9936-621: The course of the illness, but this happened most frequently during the first week of the rash when most of the skin lesions were intact. Infectivity waned in 7 to 10 days when scabs formed over the lesions, but the infected person was contagious until the last smallpox scab fell off. Concern about possible use of smallpox for biological warfare led in 2002 to Donald K. Milton's detailed review of existing research on its transmission and of then-current recommendations for controlling its spread. He agreed, citing Rao, Fenner and others, that “careful epidemiologic investigation rarely implicated fomites as

10074-511: The deep split between Leang Panninge and Aboriginal/Papuans. Mallick et al. 2016 and Mark Lipson et al. 2017 study found the bifurcation of Eastern Eurasians and Western Eurasians dates to least 45,000 years ago, with indigenous Australians nested inside the Eastern Eurasian clade. Two genetic studies by Larena et al. 2021 found that Philippines Negrito people split from the common ancestor of Aboriginal Australians and Papuans before

10212-497: The desert-dwelling Pitjantjatjara people compared with a group of European people showed that the cooling adaptation of the Aboriginal group differed from that of the white people, and that they were able to sleep more soundly through a cold desert night. A 2014 Cambridge University study found that a beneficial mutation in two genes which regulate thyroxine , a hormone involved in regulating body metabolism , helps to regulate body temperature in response to fever. The effect of this

10350-403: The diagnosis of infection. Chickenpox was commonly confused with smallpox in the immediate post-eradication era. Chickenpox and smallpox could be distinguished by several methods. Unlike smallpox, chickenpox does not usually affect the palms and soles. Additionally, chickenpox pustules are of varying size due to variations in the timing of pustule eruption: smallpox pustules are all very nearly

10488-580: The disease dates to around 1500 BC in Egyptian mummies . The disease historically occurred in outbreaks . It was one of several diseases introduced by the Columbian exchange to the New World , resulting in large swathes of Native Americans dying . In 18th-century Europe, it is estimated that 400,000 people died from the disease per year, and that one-third of all cases of blindness were due to smallpox. Smallpox

10626-479: The disease included fever and vomiting. This was followed by formation of ulcers in the mouth and a skin rash . Over a number of days, the skin rash turned into the characteristic fluid-filled blisters with a dent in the center. The bumps then scabbed over and fell off, leaving scars. The disease was transmitted from one person to another primarily through prolonged face-to-face contact with an infected person or rarely via contaminated objects . Prevention

10764-408: The genome of vaccinia , a related virus used for vaccination against smallpox. Gene expression of variola virus occurs entirely within the cytoplasm of the host cell , and follows a distinct progression during infection. After entry of an infectious virion into a host cell, synthesis of viral mRNA can be detected within 20 minutes. About half of the viral genome is transcribed prior to

10902-429: The group was able to recreate viable virus in a short time frame with relatively little cost or effort. Although the WHO bans individual laboratories from synthesizing more than 20% of the genome at a time, and purchases of smallpox genome fragments are monitored and regulated, a group with malicious intentions could compile, from multiple sources, the full synthetic genome necessary to produce viable virus. Smallpox

11040-694: The haplogroup C chromosomes. They found a divergence time of about 54,100 years between the Sahul C chromosome and its closest relative C5, as well as about 54,300 years between haplogroups K*/M and their closest haplogroups R and Q. The deep divergence time of 50,000-plus years with the South Asian chromosome and "the fact that the Aboriginal Australian Cs share a more recent common ancestor with Papuan Cs" excludes any recent genetic contact. The 2016 study's authors concluded that, although this does not disprove

11178-495: The hosts' immune systems, and are primarily responsible for the variability in virulence across the orthopoxvirus family. These terminal regions in poxviruses are inverted terminal repetitions (ITR) sequences. These sequences are identical but oppositely oriented on either end of the genome, leading to the genome being a continuous loop of DNA. Components of the ITR sequences include an incompletely base paired A/T rich hairpin loop ,

11316-401: The idea of ancient Aboriginal isolation. Genetic data extracted in 2011 by Morten Rasmussen et al., who took a DNA sample from an early-20th-century lock of an Aboriginal person's hair, found that the Aboriginal ancestors probably migrated through South Asia and Maritime Southeast Asia , into Australia, where they stayed. As a result, outside of Africa, the Aboriginal peoples have occupied

11454-653: The increased suicide rate, many researchers have suggested that the inclusion of more cultural aspects into suicide prevention programs would help to combat mental health issues within the community. Past studies have found that many indigenous leaders and community members, do in fact, want more culturally-aware health care programs. Similarly, culturally-relative programs targeting indigenous youth have actively challenged suicide ideation among younger indigenous populations, with many social and emotional wellbeing programs using cultural information to provide coping mechanisms and improving mental health. The outstation movement of

11592-506: The indigenous populations of Borneo and Malaysia , sharing drift with them than compared to the groups from Papua New Guinea and Indonesia. This indicates that populations in Australia were isolated for a long time from the rest of Southeast Asia. They remained untouched by migrations and population expansions into that area, which can be explained by the Wallace line . In a 2001 study, blood samples were collected from some Warlpiri people in

11730-412: The inland Dharug and the coastal Dharug, katungal or "sea people". The latter built canoes , and their diet was primarily seafood, including fish and shellfish from Sydney Harbour , Botany Bay and their associated rivers. The inland Dharug were paiendra or tool people. They hunted kangaroos , emus and other land animals, and used stone axes more extensively. The Dharug nation was divided up into

11868-566: The islands of Tasmania , K'gari (previously Fraser Island) , Hinchinbrook Island , the Tiwi Islands , Kangaroo Island and Groote Eylandt . Indigenous people of the Torres Strait Islands, however, are not Aboriginal. In the 2021 census , people who self-identified on the census form as being of Aboriginal and/or Torres Strait Islander origin totalled 812,728 out of a total of 25,422,788 Australians, equating to 3.2% of Australia's population and an increase of 163,557 people, or 25.2%, since

12006-450: The land was inundated at the start of the Holocene , the inter-glacial period that started about 11,700 years ago. Scholars of this ancient history believe that it would have been difficult for Aboriginal people to have originated purely from mainland Asia. Not enough people would have migrated to Australia and surrounding islands to fulfill the beginning of the size of the population seen in

12144-406: The last 10,000 years it may have occurred—newer analytical techniques have the potential to address such questions. Bergstrom's 2018 doctoral thesis looking at the population of Sahul suggests that other than relatively recent admixture, the populations of the region appear to have been genetically independent from the rest of the world since their divergence about 50,000 years ago. He writes "There

12282-518: The latter two diverged from each other, but after their common ancestor diverged from the ancestor of East Asian peoples . The dingo reached Australia about 4,000 years ago. Near that time, there were changes in language (with the Pama-Nyungan language family spreading over most of the mainland), and in stone tool technology. Smaller tools were used. Human contact has thus been inferred, and genetic data of two kinds have been proposed to support

12420-436: The lesions remained almost flush with the skin at the time when raised vesicles would have formed in the ordinary type. It is unknown why some people developed this type. Historically, it accounted for 5–10% of cases, and most (72%) were children. Malignant smallpox was accompanied by a severe prodromal phase that lasted 3–4 days, prolonged high fever, and severe symptoms of viremia . The prodromal symptoms continued even after

12558-496: The likely migration routes of the peoples as they moved across the Australian continent to its southern reaches and what is now Tasmania , then part of the mainland. The modelling is based on data from archaeologists , anthropologists , ecologists , geneticists , climatologists , geomorphologists , and hydrologists . It is intended to compare this data with the oral histories of Aboriginal peoples, including Dreaming stories, Australian rock art , and linguistic features of

12696-406: The lower respiratory tract] are maintained”. Once inhaled, the variola virus invaded the mucous membranes of the mouth, throat, and respiratory tract. From there, it migrated to regional lymph nodes and began to multiply. In the initial growth phase, the virus seemed to move from cell to cell, but by around the 12th day, widespread lysis of infected cells occurred and the virus could be found in

12834-408: The malignant and hemorrhagic forms were usually fatal. The modified form was almost never fatal. In early hemorrhagic cases, hemorrhages occurred before any skin lesions developed. The incubation period between contraction and the first obvious symptoms of the disease was 7–14 days. At least 90% of smallpox cases among unvaccinated persons were of the ordinary type. In this form of the disease, by

12972-423: The many Aboriginal languages which reveal how the peoples developed separately. The routes, dubbed "superhighways" by the authors, are similar to current highways and stock routes in Australia. Lynette Russell of Monash University believes that the new model is a starting point for collaboration with Aboriginal people to help reveal their history. The new models suggest that the first people may have landed in

13110-403: The micro-level (tribe, clan, etc.), and others on shared languages and cultural practices spread over large regions defined by ecological factors. Anthropologists have encountered many difficulties in trying to define what constitutes an Aboriginal people/community/group/tribe, let alone naming them. Knowledge of pre-colonial Aboriginal cultures and societal groupings is still largely dependent on

13248-411: The observers' interpretations, which were filtered through colonial ways of viewing societies. Some Aboriginal peoples identify as one of several saltwater, freshwater, rainforest or desert peoples . The term Aboriginal Australians includes many distinct peoples who have developed across Australia for over 50,000 years. These peoples have a broadly shared, though complex, genetic history, but it

13386-418: The oldest continuous cultures in the world, although this is disputed. At the time of European colonisation of Australia, the Aboriginal people consisted of complex cultural societies with more than 250 languages and varying degrees of technology and settlements. Languages (or dialects) and language-associated groups of people are connected with stretches of territory known as "Country", with which they have

13524-633: The oldest living populations in the world, certainly the oldest outside of Africa." Their ancestors left the African continent 75,000 years ago. They may have the oldest continuous culture on earth. In Arnhem Land in the Northern Territory , oral histories comprising complex narratives have been passed down by Yolngu people through hundreds of generations. The Aboriginal rock art , dated by modern techniques, shows that their culture has continued from ancient times. The ancestors of present-day Aboriginal Australian people migrated from Southeast Asia by sea during

13662-404: The onset of the rash. The rash on the mucous membranes ( enanthem ) was extensive. Skin lesions matured slowly, were typically confluent or semi-confluent, and by the seventh or eighth day, they were flat and appeared to be buried in the skin. Unlike ordinary-type smallpox, the vesicles contained little fluid, were soft and velvety to the touch, and may have contained hemorrhages. Malignant smallpox

13800-429: The oral, nasal, or pharyngeal mucosa of an infected person. It was transmitted from one person to another primarily through prolonged face-to-face contact with an infected person. Some infections of laundry workers with smallpox after handling contaminated bedding suggested that smallpox could be spread through direct contact with contaminated objects ( fomites ), but this was found to be rare. Also rarely, smallpox

13938-474: The original 250–400 Aboriginal languages (more than 250 languages and about 800 dialectal varieties on the continent) are endangered or extinct, although some efforts are being made at language revival for some. As of 2016, only 13 traditional Indigenous languages were still being acquired by children, and about another 100 spoken by older generations only. Dispersing across the Australian continent over time,

14076-420: The other studies had utilised complete Y chromosome sequencing, which has the highest precision. For example, use of a ten Y STRs method has been shown to massively underestimate divergence times. Gene flow across the island-dotted 150-kilometre-wide (93 mi) Torres Strait, is both geographically plausible and demonstrated by the data, although at this point it could not be determined from this study when within

14214-523: The outer layers of skin from the underlying flesh. Patients with confluent smallpox often remained ill even after scabs had formed over all the lesions. In one case series, the case-fatality rate in confluent smallpox was 62%. Referring to the character of the eruption and the rapidity of its development, modified smallpox occurred mostly in previously vaccinated people. It was rare in unvaccinated people, with one case study showing 1–2% of modified cases compared to around 25% in vaccinated people. In this form,

14352-573: The person was infected with variola virus, a severe infection could result, and the person could transmit smallpox to others. Variolation had a 0.5–2 percent mortality rate, considerably less than the 20–30 percent mortality rate of smallpox. Two reports on the Chinese practice of inoculation were received by the Royal Society in London in 1700; one by Dr. Martin Lister who received a report by an employee of

14490-493: The practice arrived in Europe. The idea that inoculation originated in India has been challenged, as few of the ancient Sanskrit medical texts described the process of inoculation. Accounts of inoculation against smallpox in China can be found as early as the late 10th century, and the procedure was widely practiced by the 16th century, during the Ming dynasty . If successful, inoculation produced lasting immunity to smallpox. Because

14628-440: The presence of any Holocene gene flow or non-genetic influences from South Asia at that time, and the appearance of the dingo does provide strong evidence for external contacts, the evidence overall is consistent with a complete lack of gene flow, and points to indigenous origins for the technological and linguistic changes. They attributed the disparity between their results and previous findings to improvements in technology; none of

14766-414: The previous census in 2016. Reasons for the increase were broadly as follows: Most Aboriginal people speak English, with Aboriginal phrases and words being added to create Australian Aboriginal English (which also has a tangible influence of Aboriginal languages in the phonology and grammatical structure ). Some Aboriginal people, especially those living in remote areas, are multi-lingual. Many of

14904-491: The prodromal illness still occurred but may have been less severe than in the ordinary type. There was usually no fever during the evolution of the rash. The skin lesions tended to be fewer and evolved more quickly, were more superficial, and may not have shown the uniform characteristic of more typical smallpox. Modified smallpox was rarely, if ever, fatal. This form of variola major was more easily confused with chickenpox . In malignant-type smallpox (also called flat smallpox)

15042-487: The remaining land bridge was impassable. This isolation makes the Aboriginal people the world's oldest culture. The study also found evidence of an unknown hominin group, distantly related to Denisovans, with whom the Aboriginal and Papuan ancestors must have interbred, leaving a trace of about 4% in most Aboriginal Australians' genome. There is, however, increased genetic diversity among Aboriginal Australians based on geographical distribution. Carlhoff et al. 2021 analysed

15180-457: The river and to the food supply of the Dharug people, who were rightly upset by this invasion. The Dharug who crossed the farms to pick up corn were killed by the settlers, so they organized raids to burn the crops. The conflict scaled and in 1795 the government provided troops to protect the farms. The bodies of any Dharug killed were to be put in iron gibbets and hung from trees as a warning. In 1801, Governor King ordered troops to patrol farms on

15318-454: The same size since the viral effect progresses more uniformly. A variety of laboratory methods were available for detecting chickenpox in the evaluation of suspected smallpox cases. The earliest procedure used to prevent smallpox was inoculation with variola minor virus (a method later known as variolation after the introduction of smallpox vaccine to avoid possible confusion), which likely occurred in India, Africa, and China well before

15456-406: The same territory continuously longer than any other human populations. These findings suggest that modern Aboriginal Australians are the direct descendants of the eastern wave, who left Africa up to 75,000 years ago. This finding is compatible with earlier archaeological finds of human remains near Lake Mungo that date to approximately 40,000 years ago. The idea of the "oldest continuous culture"

15594-479: The second day of the rash the macules had become raised papules . By the third or fourth day, the papules had filled with an opalescent fluid to become vesicles . This fluid became opaque and turbid within 24–48 hours, resulting in pustules . By the sixth or seventh day, all the skin lesions had become pustules. Between seven and ten days the pustules had matured and reached their maximum size. The pustules were sharply raised, typically round, tense, and firm to

15732-491: The separation of variola virus from Taterapox (an Orthopoxvirus of some African rodents including gerbils ) at 3,000 to 4,000 years ago. This is consistent with archaeological and historical evidence regarding the appearance of smallpox as a human disease which suggests a relatively recent origin. If the mutation rate is assumed to be similar to that of the herpesviruses , the divergence date of variola virus from Taterapox has been estimated to be 50,000 years ago. While this

15870-526: The smaller offshore islands and Tasmania when the land was inundated at the start of the Holocene inter-glacial period , about 11,700 years ago. Despite this, Aboriginal people maintained extensive networks within the continent and certain groups maintained relationships with Torres Strait Islanders and the Makassar people of modern-day Indonesia. Aboriginal Australians have a wide variety of cultural practices and beliefs that some scientists believe make up

16008-520: The spleen, kidney, serous membranes , skeletal muscles, pericardium , liver, gonads and bladder. Historically, this condition was frequently misdiagnosed, with the correct diagnosis made only at autopsy. This form is more likely to occur in pregnant women than in the general population (approximately 16% of cases in unvaccinated pregnant women were early hemorrhagic smallpox, versus roughly 1% in nonpregnant women and adult males). The case fatality rate of early hemorrhagic smallpox approaches 100%. There

16146-572: The story of creation known as The Dreamtime . Additionally, traditional healers were also custodians of important Dreaming stories as well as their medical roles (for example the Ngangkari in the Western desert ). Some core structures and themes are shared across the continent with details and additional elements varying between language and cultural groups. For example, in The Dreamtime of most regions,

16284-425: The temperature fell to near-normal. These lesions rapidly enlarged and ruptured, releasing large amounts of virus into the saliva. Variola virus tended to attack skin cells, causing the characteristic pimples, or macules , associated with the disease. A rash developed on the skin 24 to 48 hours after lesions on the mucous membranes appeared. Typically the macules first appeared on the forehead, then rapidly spread to

16422-409: The term Aboriginal has changed over time and place, with the importance of family lineage, self-identification and community acceptance all being of varying importance. The term Indigenous Australians refers to Aboriginal Australians and Torres Strait Islander peoples, and the term is conventionally only used when both groups are included in the topic being addressed, or by self-identification by

16560-411: The touch. The pustules were deeply embedded in the dermis, giving them the feel of a small bead in the skin. Fluid slowly leaked from the pustules, and by the end of the second week, the pustules had deflated and began to dry up, forming crusts or scabs. By day 16–20 scabs had formed over all of the lesions, which had started to flake off, leaving depigmented scars. Ordinary smallpox generally produced

16698-465: The various Indigenous peoples of the Australian mainland and many of its islands, excluding the ethnically distinct people of the Torres Strait Islands . Humans first migrated to Australia at least 65,000 years ago, and over time formed as many as 500 language-based groups . In the past, Aboriginal people lived over large sections of the continental shelf . They were isolated on many of

16836-475: The vesicular stage. Hemorrhages in the mucous membranes appear to occur less often than in the early hemorrhagic form. Sometimes the rash forms pustules which bleed at the base and then undergo the same process as in ordinary smallpox. This form of the disease is characterized by a decrease in all of the elements of the coagulation cascade and an increase in circulating antithrombin . This form of smallpox occurs anywhere from 3% to 25% of fatal cases, depending on

16974-439: The virulence of the smallpox strain. Most people with the late-stage form die within eight to 10 days of illness. Among the few who recover, the hemorrhagic lesions gradually disappear after a long period of convalescence. The case fatality rate for late hemorrhagic smallpox is around 90–95%. Pregnant women are slightly more likely to experience this form of the disease, though not as much as early hemorrhagic smallpox. Smallpox

17112-442: The virus on chorioallantoic membrane (part of a chicken embryo ) and examining the resulting pock lesions under defined temperature conditions. Strains were characterized by polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) analysis. Serologic tests and enzyme linked immunosorbent assays (ELISA), which measured variola virus-specific immunoglobulin and antigen were also developed to assist in

17250-551: The whole face, proximal portions of extremities, the trunk, and lastly to distal portions of extremities. The process took no more than 24 to 36 hours, after which no new lesions appeared. At this point, variola major disease could take several very different courses, which resulted in four types of smallpox disease based on the Rao classification: ordinary, modified, malignant (or flat), and hemorrhagic smallpox. Historically, ordinary smallpox had an overall fatality rate of about 30%, and

17388-517: The wider Australian community. Due to the aforementioned disadvantage, Aboriginal Australian communities experience a higher rate of suicide, as compared to non-indigenous communities. These issues stem from a variety of different causes unique to indigenous communities, such as historical trauma, socioeconomic disadvantage, and decreased access to education and health care. Also, this problem largely affects indigenous youth, as many indigenous youth may feel disconnected from their culture. To combat

17526-575: Was Mosquito . He led a group for two decades, until he was captured and hanged in Van Diemen's land in 1823. Smallpox , introduced in 1789 by the British, wiped out up to 90% of the population in some areas. They lived in the natural caves and overhangs in the sandstone of the Hawksbury region, although some did choose to make huts out of bark, sticks and branches. A strong centre of cultural attachment for

17664-421: Was achieved mainly through the smallpox vaccine . Once the disease had developed, certain antiviral medications could potentially have helped, but such medications did not become available until after the disease was eradicated. The risk of death was about 30%, with higher rates among babies. Often, those who survived had extensive scarring of their skin, and some were left blind. The earliest evidence of

17802-431: Was also called white pox, kaffir pox, Cuban itch, West Indian pox, milk pox, and pseudovariola. The genome of variola major virus is about 186,000 base pairs in length. It is made from linear double stranded DNA and contains the coding sequence for about 200 genes . The genes are usually not overlapping and typically occur in blocks that point towards the closer terminal region of the genome. The coding sequence of

17940-428: Was highly contagious, but generally spread more slowly and less widely than some other viral diseases, perhaps because transmission required close contact and occurred after the onset of the rash. The overall rate of infection was also affected by the short duration of the infectious stage. In temperate areas, the number of smallpox infections was highest during the winter and spring. In tropical areas, seasonal variation

18078-547: Was launched calling for the recognition of the Dharug people in 2012. In 2020, the Hills Shire Council , whose local government area covers Dharug land, caused controversy by rejecting requests to include an Acknowledgement of Country at its meetings. The Hills Shire Council is the only Sydney local council that does not include an Acknowledgement of Country at its meetings. Source: Tindale 1974 , p. 193 Aboriginal Australian Aboriginal Australians are

18216-442: Was less evident and the disease was present throughout the year. Age distribution of smallpox infections depended on acquired immunity . Vaccination immunity declined over time and was probably lost within thirty years. Smallpox was not known to be transmitted by insects or animals and there was no asymptomatic carrier state. Transmission occurred through inhalation of airborne variola virus, usually droplets expressed from

18354-404: Was marked by a fever that occurred after the usual incubation period and could be confirmed only by antibody studies or, rarely, by viral culture . In addition, there were two very rare and fulminating types of smallpox, the malignant (flat) and hemorrhagic forms, which were usually fatal. The initial symptoms were similar to other viral diseases that are still extant, such as influenza and

18492-421: Was nearly always fatal and death usually occurred between the 8th and 12th day of illness. Often, a day or two before death, the lesions turned ashen gray, which, along with abdominal distension, was a bad prognostic sign. This form is thought to be caused by deficient cell-mediated immunity to smallpox. If the person recovered, the lesions gradually faded and did not form scars or scabs. Hemorrhagic smallpox

18630-552: Was severely wounded and fled. His band was accused of killing four settlers and falsely accused of raping women. The government issued orders for his capture, dead or alive. He was killed by two settlers in 1802, and his head was severed, pickled and dispatched by King to Sir Joseph Banks . To date Pemulwuy's head has not been returned and he has not had a proper burial. It is 'lost' in the British Museum in London. Pemulwuy's son, Tedbury , raided farms until 1810. Another famous raider

18768-440: Was spread by virus carried in the air in enclosed settings such as buildings, buses, and trains. The virus can cross the placenta , but the incidence of congenital smallpox was relatively low. Smallpox was not notably infectious in the prodromal period and viral shedding was usually delayed until the appearance of the rash, which was often accompanied by lesions in the mouth and pharynx. The virus can be transmitted throughout

18906-404: Was the primary cause of smallpox outbreaks across Asia and most of Africa. Meanwhile, variola minor was more commonly found in regions of Europe, North America, South America, and certain parts of Africa. Variola minor virus, also called alastrim, was a less common form of the virus, and much less deadly. Although variola minor had the same incubation period and pathogenetic stages as smallpox, it

19044-511: Was the variola major strains (the more clinically severe form of smallpox) which spread from Asia between 400 and 1,600 years ago. A second clade included both alastrim (a phenotypically mild smallpox) described from the American continents and isolates from West Africa which diverged from an ancestral strain between 1,400 and 6,300 years before present. This clade further diverged into two subclades at least 800 years ago. A second estimate has placed

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