127-587: Dairy products or milk products , also known as lacticinia , are food products made from (or containing) milk . The most common dairy animals are cow , water buffalo , nanny goat , and ewe . Dairy products include common grocery store food around the world such as yogurt , cheese , milk and butter . A facility that produces dairy products is a dairy . Dairy products are consumed worldwide to varying degrees. Some people avoid some or all dairy products because of lactose intolerance , veganism , environmental concerns , other health reasons or beliefs. Milk
254-463: A milk allergy . People who experience lactose intolerance usually avoid milk and other lactose-containing dairy products, which may cause mild side effects , such as abdominal pain, bloating, diarrhea, gas, and nausea. Such individuals may use non-dairy milk substitutes . The American Institute for Cancer Research (AICR), World Cancer Research Fund International (WCRF), Cancer Council Australia (CCA) and Cancer Research UK have stated that there
381-492: A rattling noise as fluid lingers in the throat, but this is not uncomfortable for the affected person. Their hands and feet may cool to the touch, and skin become blotchy or blue due to weaker blood circulation. Many stop eating and drinking, resulting in dry-feeling mouth, which can be aided by moistening the mouth and lips. The person becomes less and less responsive, and eventually the heart and breathing stop. The prognosis of diagnosed prostate cancer varies widely based on
508-411: A PSMA-targeting drug, each of which is able to detect small metastases more sensitively than alternative imaging methods. For those with metastatic disease, the standard of care is androgen deprivation therapy (also called "chemical castration"), drugs that reduce levels of androgens (male sex hormones) that prostate cells require to grow. Various drugs are used to lower androgen levels by blocking
635-1057: A combination of the disease itself, poor nutrition, and damage to the bone marrow from cancer treatments or bone metastases. Anemia can be treated in various ways depending on the cause, or can be addressed directly with blood transfusions . Organ damage and metastases in the lymph nodes can lead to uncomfortable accumulation of fluid (called lymphedema ) in the genitals or lower limbs. These swellings can be extremely painful, curtailing an affected person's ability to urinate, have sex, or walk normally. Lymphedema can be treated by applying pressure to aid drainage, surgically draining pooled fluid, and cleaning and treating nearby damaged skin. People with prostate cancer are around twice as likely to experience anxiety or depression compared to those without cancer. When added to normal prostate cancer treatments, psychological interventions such as psychoeducation and cognitive behavioral therapy can help reduce anxiety, depression, and general distress. As those severely ill with metastatic prostate cancer approach
762-743: A diverse range of species from annelids to elephants, chimpanzees and many birds. About 182 fish consume seeds or fruit. Animals (domesticated and wild) use as many types of grasses that have adapted to different locations as their main source of nutrients. Humans eat thousands of plant species; there may be as many as 75,000 edible species of angiosperms , of which perhaps 7,000 are often eaten. Plants can be processed into breads, pasta, cereals, juices and jams or raw ingredients such as sugar, herbs, spices and oils can be extracted. Oilseeds are pressed to produce rich oils – sunflower , flaxseed , rapeseed (including canola oil ) and sesame . Many plants and animals have coevolved in such
889-407: A fragment called −2proPSA) and 4K score (measures intact free PSA). Other tests measure blood levels of additional prostate-related proteins such as kallikrein-2 (also measured by 4K score), or urine levels of mRNA molecules common to prostate tumors like PCA3 and TMPRSS2 fused to ERG . Several large studies have found that men screened for prostate cancer have a reduced risk of dying from
1016-475: A heart-healthy eating pattern and choosing reduced-fat dairy over full-fat dairy reduces risk for some, but not all, cardiovascular risk factors". In 2019 the National Heart Foundation of Australia published a position statement on full fat dairy products, "Based on current evidence, there is not enough evidence to recommend full fat over reduced fat products or reduced fat over full fat products for
1143-583: A high protein, fibre, vitamin E and B content. Seeds are a good source of food for animals because they are abundant and contain fibre and healthful fats, such as omega-3 fats . Complicated chemical interactions can enhance or depress bioavailability of certain nutrients. Phytates can prevent the release of some sugars and vitamins. Animals that only eat plants are called herbivores , with those that mostly just eat fruits known as frugivores , leaves, while shoot eaters are folivores (pandas) and wood eaters termed xylophages (termites). Frugivores include
1270-475: A higher-risk tumor that may require intervention. At least half of men remain on active surveillance, never requiring more direct treatment for their prostate tumors. Those who elect to have therapy receive radiation therapy or a prostatectomy ; these have similar rates of cancer control, but different side effects. Radiation can be delivered by intensity-modulated radiation therapy (IMRT), which allows for high doses (greater than 80 Gy ) to be delivered to
1397-415: A history of gonorrhea , syphilis , chlamydia , or infection with various human papillomaviruses . Regular vigorous exercise may reduce one's chance of developing advanced prostate cancer, as can several dietary interventions. Those with a diet rich in cruciferous vegetables (certain leafy greens, broccoli, and cauliflower), fish , genistein (found in soy ), or lycopene (found in tomatoes) are at
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#17328511093741524-663: A history of any cancer. Men with an affected first-degree relative (father or brother) have more than twice the risk of developing prostate cancer, and those with two first-degree relatives have a five-fold greater risk compared with men with no family history. Increased risk also runs in some ethnic groups, with men of African and African-Caribbean ancestry at particularly high risk – having prostate cancer at higher rates, and having more-aggressive prostate cancers that develop at earlier ages. Large genome-wide association studies have identified over 100 gene variants associated with increased prostate cancer risk. The greatest risk increase
1651-469: A low Gleason grade and less-advanced clinical stage tend to have better prognoses. After prostatectomy or radiotherapy, those who have a short time between treatment and a subsequent rise in PSA levels, or quickly rising PSA levels are more likely to die from their cancers. Castration-resistant metastatic prostate cancer is incurable, and kills a majority of those whose disease reaches this stage. Prostate cancer
1778-425: A man who had died with urinary issues; Adams had a pathologist examine the tumor, providing the first confirmed case of a cancerous tumor in the prostate. The disease was initially rarely described; an 1893 report found only 50 cases described in the medical literature. Around the turn of the 19th century, prostate surgery to relieve urinary obstruction became more common, allowing surgeons and pathologists to examine
1905-678: A million. Herbivores generally have more than carnivores as they need to tell which plants may be poisonous. Not all mammals share the same tastes: some rodents can taste starch , cats cannot taste sweetness, and several carnivores (including hyenas , dolphins, and sea lions) have lost the ability to sense up to four of the five taste modalities found in humans. Food is broken into nutrient components through digestive process. Proper digestion consists of mechanical processes ( chewing , peristalsis ) and chemical processes ( digestive enzymes and microorganisms ). The digestive systems of herbivores and carnivores are very different as plant matter
2032-976: A reduced risk of symptomatic prostate cancer. Conversely, those who consume high levels of dietary fats, polycyclic aromatic hydrocarbons (from cooking red meats), or calcium may be at an increased risk of developing advanced prostate cancer. Several dietary supplements have been studied and found not to impact prostate cancer risk, including selenium , vitamin C , vitamin D , and vitamin E . Transgender women and gender non-conforming people who have prostates can develop prostate cancer. Those who have undergone gender-affirming hormone therapy or gender-affirming surgery have reduced risk of developing prostate cancer, relative to cisgender men of similar age. Screening tests in this group are complicated, as transgender women may have lower PSA levels than cisgender men due to their reduced testosterone levels. PSA levels greater than 1 ng/mL are generally considered above normal by gender care specialists. Digital rectal exams of
2159-632: A result of hormones". In 2024, Cancer Research UK stated "there is no reliable evidence that casein or hormones in dairy causes cancer in people". The American Medical Association (AMA) recommends that people replace full-fat dairy products with nonfat and low-fat dairy products. In 2017, the AMA stated that there is no high-quality clinical evidence that cheese consumption lowers the risk of cardiovascular disease. In 2021, they stated that "taken together, replacing full-fat dairy products with nonfat and low-fat dairy products and other sources of unsaturated fat shifts
2286-407: A rise in PSA levels, suggesting the tumor or small metastases are growing again. People with high or rising PSA levels are often offered another round of radiation therapy directed at the former tumor site. This reduces risk for further progression by 75%. Those suspected of metastases can undergo PET scanning with sensitive radiotracers C-11 choline, F-18 fluciclovine, and F-18 or Ga-68 attached to
2413-544: A slightly increased risk for developing prostate cancer, as are men who are obese . High levels of blood cholesterol are also associated with increased prostate cancer risk; consequently, those who take the cholesterol-lowering drugs, statins , have a reduced risk of advanced prostate cancer. Chronic inflammation can cause various cancers. Potential links between infection (or other sources of inflammation) and prostate cancer have been studied but none definitively found, and one large study found no link between prostate cancer and
2540-546: A source of food for protozoa, who in turn provide a source of food for other organisms such as small invertebrates. Other organisms that feed on bacteria include nematodes, fan worms, shellfish and a species of snail. In the marine environment, plankton (which includes bacteria , archaea , algae , protozoa and microscopic fungi ) provide a crucial source of food to many small and large aquatic organisms. Without bacteria, life would scarcely exist because bacteria convert atmospheric nitrogen into nutritious ammonia . Ammonia
2667-425: A system with nineteen food classifications: cereals, roots, pulses and nuts, milk, eggs, fish and shellfish, meat, insects, vegetables, fruits, fats and oils, sweets and sugars, spices and condiments, beverages, foods for nutritional uses, food additives, composite dishes and savoury snacks. In a given ecosystem, food forms a web of interlocking chains with primary producers at the bottom and apex predators at
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#17328511093742794-406: A tumor can grow large enough to invade nearby organs such as the seminal vesicles or bladder . In advanced tumors, cells can develop the ability to detach from their original tissue site, and evade the immune system . These cells can spread through the lymphatic system to nearby lymph nodes , or through the bloodstream to the bone marrow and (more rarely) other body sites. At these new sites,
2921-568: A tumor that has grown beyond the prostate (T3). CPG 5 is for the highest risk cases: either a T4 tumor, Gleason grade group 5, or any two of the CPG ;4 criteria. No drug or vaccine is approved by regulatory agencies for the prevention of prostate cancer. Several studies have shown 5α-reductase inhibitors to reduce the total incidence of prostate cancer; however, it is unclear as of 2022 whether they reduce any cases of dangerous disease. Treatment of prostate cancer varies based on how advanced
3048-456: A way that the fruit is a good source of nutrition to the animal who then excretes the seeds some distance away, allowing greater dispersal. Even seed predation can be mutually beneficial, as some seeds can survive the digestion process. Insects are major eaters of seeds, with ants being the only real seed dispersers. Birds, although being major dispersers, only rarely eat seeds as a source of food and can be identified by their thick beak that
3175-646: A wide range of other social and political issues, including sustainability , biological diversity , economics , population growth , water supply , and food security . Food safety and security are monitored by international agencies like the International Association for Food Protection , the World Resources Institute , the World Food Programme , the Food and Agriculture Organization , and
3302-515: Is ingested by an organism and assimilated by the organism's cells to provide energy, maintain life, or stimulate growth. Different species of animals have different feeding behaviours that satisfy the needs of their metabolisms and have evolved to fill a specific ecological niche within specific geographical contexts. Omnivorous humans are highly adaptable and have adapted to obtain food in many different ecosystems. Humans generally use cooking to prepare food for consumption. The majority of
3429-580: Is "insufficient evidence to draw any firm conclusions as to whether exposure to dietary IGF-1 is associated with an increased incidence of cancer in consumers". The COC also stated it is unlikely that there would be absorption of intact IGF-1 from food by most consumers. A 2019 review concluded that higher-quality research was needed to characterise valid associations between dairy consumption and risk of and/or cancer-related mortality. A 2021 umbrella review found strong evidence that consumption of dairy products decreases risk of colorectal cancer. Fermented dairy
3556-447: Is a fruit if the part eaten is derived from the reproductive tissue , so seeds, nuts and grains are technically fruit. From a culinary perspective, fruits are generally considered the remains of botanically described fruits after grains, nuts, seeds and fruits used as vegetables are removed. Grains can be defined as seeds that humans eat or harvest, with cereal grains (oats, wheat, rice, corn, barley, rye, sorghum and millet) belonging to
3683-415: Is a major topic of ongoing research. From 2016–2020, over $ 1.26 billion was invested in prostate cancer research, representing around 5% of global cancer research funds. This places prostate cancer 10th among 18 common cancer types in funding per cancer death, and 9th in funding per disability-adjusted life year lost. Research into prostate cancer relies on a number of laboratory models to test aspects of
3810-696: Is a sensation considered unpleasant characterised by having a sharp, pungent taste. Unsweetened dark chocolate, caffeine , lemon rind, and some types of fruit are known to be bitter. Umami, commonly described as savory, is a marker of proteins and characteristic of broths and cooked meats. Foods that have a strong umami flavor include cheese, meat and mushrooms. While most animals taste buds are located in their mouth, some insects taste receptors are located on their legs and some fish have taste buds along their entire body. Dogs, cats and birds have relatively few taste buds (chickens have about 30), adult humans have between 2000 and 4000, while catfish can have more than
3937-407: Is associated with significantly decreased bladder cancer and colorectal cancer risk. A 2023 review found no association between consumption of dairy products and breast cancer . The British Dietetic Association have described the idea that milk promotes hormone related cancerous tumour growth as a myth, stating "no link between dairy containing diets and risk of cancer or promoting cancer growth as
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4064-562: Is associated with variations in BRCA2 (up to an eight-fold increased risk) and HOXB13 (three-fold increased risk), both of which are involved in repairing DNA damage . Variants in other genes involved in DNA damage repair have also been associated with an increased risk of developing prostate cancer – particularly early-onset prostate cancer – including BRCA1 , ATM , NBS1 , MSH2 , MSH6 , PMS2 , CHEK2 , RAD51D , and PALB2 . Additionally, variants in
4191-402: Is caused by acids , such as vinegar in alcoholic beverages. Sour foods include citrus, specifically lemons and limes . Sour is evolutionarily significant as it can signal a food that may have gone rancid due to bacteria. Saltiness is the taste of alkali metal ions such as sodium and potassium. It is found in almost every food in low to moderate proportions to enhance flavor. Bitter taste
4318-507: Is caused by the accumulation of genetic mutations to the DNA of cells in the prostate. These mutations affect genes involved in cell growth, replication, cell death , and DNA damage repair . With these processes dysregulated, some cells replicate abnormally, forming a clump of cells called a tumor. As the tumor grows, its cells accumulate more mutations, allowing it to stimulate the growth of new blood vessels to support further growth. Eventually,
4445-412: Is done through blood tests to measure levels of the protein prostate-specific antigen (PSA), which are elevated in those with enlarged prostates, whether due to prostate cancer or benign prostatic hyperplasia . The typical man's blood has around 1 nanogram (ng) of PSA per milliliter (mL) of blood tested. Those with PSA levels below average are very unlikely to develop dangerous prostate cancer over
4572-731: Is drunk or processed into dairy products (cheese, butter, etc.). Eggs laid by birds and other animals are eaten and bees produce honey , a reduced nectar from flowers that is used as a popular sweetener in many cultures. Some cultures consume blood , such as in blood sausage , as a thickener for sauces, or in a cured , salted form for times of food scarcity, and others use blood in stews such as jugged hare . Animals, specifically humans, typically have five different types of tastes: sweet , sour , salty , bitter , and umami . The differing tastes are important for distinguishing between foods that are nutritionally beneficial and those which may contain harmful toxins. As animals have evolved ,
4699-874: Is found in many foods and has been defined as a food by itself. Water and fiber have low energy densities, or calories , while fat is the most energy-dense component. Some inorganic (non-food) elements are also essential for plant and animal functioning. Human food can be classified in various ways, either by related content or by how it is processed. The number and composition of food groups can vary. Most systems include four basic groups that describe their origin and relative nutritional function: Vegetables and Fruit, Cereals and Bread, Dairy, and Meat. Studies that look into diet quality group food into whole grains/cereals, refined grains/cereals, vegetables, fruits, nuts, legumes, eggs, dairy products, fish, red meat, processed meat, and sugar-sweetened beverages. The Food and Agriculture Organization and World Health Organization use
4826-491: Is harder to digest. Carnivores mouths are designed for tearing and biting compared to the grinding action found in herbivores. Herbivores however have comparatively longer digestive tracts and larger stomachs to aid in digesting the cellulose in plants. According to the World Health Organization (WHO), about 600 million people worldwide get sick and 420,000 die each year from eating contaminated food. Diarrhea
4953-1166: Is milk with zero fat, while whole milk products contain fat. Milk is an ingredient in many confectioneries. Milk can be added to chocolate to produce milk chocolate . Butter , mostly milk fat, produced by churning cream Fermented milk products include: Yogurt , milk fermented by thermophilic bacteria , mainly Streptococcus salivarius ssp. thermophilus and Lactobacillus delbrueckii ssp. bulgaricus sometimes with additional bacteria, such as Lactobacillus acidophilus Cheese , produced by coagulating milk, separating curds from whey , and letting it ripen, generally with bacteria , and sometimes also with certain molds . Rates of dairy consumption vary widely worldwide. High-consumption countries consume more than 150 kilograms (330 lb) per capita per year. These countries are: Argentina, Armenia, Australia, Costa Rica, most European countries, Israel, Kyrgyzstan, North America and Pakistan. Medium-consumption countries consume 30 kilograms (66 lb) to 150 kg per capita per year. These countries are: India, Iran, Japan, Kenya, Mexico, Mongolia, New Zealand, North and Southern Africa, most of
5080-711: Is more likely in those who are older or had previous erectile issues. Incontinence is more common in those who are older and have shorter urethras . Both for cancer progression outcomes and surgical side effects, the skill and experience of the individual surgeon doing the procedure are among the greatest determinants of success. After prostatectomy, PSA levels drop rapidly, reaching very low or undetectable levels within two months. Radiotherapy also substantially reduces PSA levels, but more slowly and less completely, with PSA levels reaching their nadir two years after radiotherapy. After either treatment, PSA levels are monitored regularly. Up to half of those treated will eventually have
5207-443: Is no conclusive evidence. Fermented and low-fat dairy products are associated with a decreased risk of diabetes . Consumption of dairy products are also associated with a decreased risk of gout . A 2023 review found that higher intake of dairy products is significantly associated with a lower risk of inflammatory bowel disease . Some groups avoid dairy products for non-health-related reasons. Some religions restrict or do not allow
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5334-412: Is produced after optional homogenization or pasteurization , in several grades after standardization of the fat level, and possible addition of the bacteria Streptococcus lactis and Leuconostoc citrovorum . Milk can be broken down into several different categories based on type of product produced, including cream, butter, cheese, infant formula, and yogurt. Milk varies in fat content. Skim milk
5461-651: Is rare in regions with a low Human Development Index . Men suspected of having prostate cancer may undergo several tests to assess the prostate. One common procedure is the digital rectal examination , in which a doctor inserts a lubricated finger into the rectum to feel the nearby prostate. Tumors feel like stiff, irregularly shaped lumps against the rest of the prostate. Hardening of the prostate can also be due to benign prostatic hyperplasia ; around 20–25% of those with abnormal findings on their rectal exams have prostate cancer. Several urological societies' guidelines recommend magnetic resonance imaging (MRI) to evaluate
5588-405: Is strong evidence that consumption of dairy products decreases risk of colorectal cancer . The AICR, WCRF, CCA and Prostate Cancer UK have stated that there is limited but suggestive evidence that dairy products increase risk of prostate cancer . The American Cancer Society (ACS) have stated that because dairy products "may lower the risk of some cancers and possibly increase the risk of others,
5715-412: Is the uncontrolled growth of cells in the prostate , a gland in the male reproductive system below the bladder . Abnormal growth of prostate tissue is usually detected through screening tests, typically blood tests that check for prostate-specific antigen (PSA) levels. Those with high levels of PSA in their blood are at increased risk for developing prostate cancer. Diagnosis requires a biopsy of
5842-414: Is the designation for any of three higher risk factors: IIIA is for a PSA level about 20 ng/mL; IIIB is for T3 or T4 tumors; IIIC is for a Gleason grade group of 5. Stage IV is for cancers that have spread to lymph nodes (N1, stage IVA) or other organs (M1, stage IVB). The United Kingdom National Institute for Health and Care Excellence recommends a five-stage system based on disease prognosis called
5969-423: Is the most advanced stage of the disease, called castration-resistant prostate cancer (CRPC). CRPC tumors continuously evolve resistance to treatments, necessitating several lines of therapy, each used in sequence to extend survival. The standard of care is the chemotherapy docetaxel along with antiandrogen drugs, namely the androgen receptor antagonists enzalutamide , apalutamide , and darolutamide , as well as
6096-497: Is the most common illness caused by consuming contaminated food, with about 550 million cases and 230,000 deaths from diarrhea each year. Children under five years of age account for 40% of the burden of foodborne illness, with 125,000 deaths each year. A 2003 World Health Organization (WHO) report concluded that about 30% of reported food poisoning outbreaks in the WHO European Region occur in private homes. According to
6223-556: Is the precursor to proteins, nucleic acids, and most vitamins. Since the advent of industrial process for nitrogen fixation, the Haber-Bosch Process , the majority of ammonia in the world is human-made. Plants as a food source are divided into seeds, fruits, vegetables, legumes, grains and nuts. Where plants fall within these categories can vary, with botanically described fruits such as the tomato, squash, pepper and eggplant or seeds like peas commonly considered vegetables. Food
6350-402: Is then released, and the glucose stored as an energy reserve. Photosynthetic plants, algae and certain bacteria often represent the lowest point of the food chains, making photosynthesis the primary source of energy and food for nearly all life on earth. Plants also absorb important nutrients and minerals from the air, natural waters, and soil. Carbon, oxygen and hydrogen are absorbed from
6477-455: Is unavailable, prostatectomy can be performed laparoscopically (using a camera and hand tools through small holes in the abdomen), or through traditional open surgery with an incision above the penis (retropubic approach) or below the scrotum (perineal approach). The four approaches result in similar rates of cancer control. Damage to nearby tissue during surgery can result in erectile dysfunction and urinary incontinence . Erectile dysfunction
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#17328511093746604-406: Is used to crack open the seed coat. Mammals eat a more diverse range of seeds, as they are able to crush harder and larger seeds with their teeth. Animals are used as food either directly or indirectly. This includes meat, eggs, shellfish and dairy products like milk and cheese. They are an important source of protein and are considered complete proteins for human consumption as they contain all
6731-474: The BRCA2 gene. Each year 1.2 million cases of prostate cancer are diagnosed, and 350,000 die of the disease, making it the second-leading cause of cancer and cancer death in men. One in eight men is diagnosed with prostate cancer in his lifetime and one in forty dies of the disease. Prostate tumors were first described in the mid-19th century, during surgeries on men with urinary obstructions. Initially, prostatectomy
6858-605: The International Food Information Council . Food is any substance consumed to provide nutritional support and energy to an organism . It can be raw, processed, or formulated and is consumed orally by animals for growth, health, or pleasure. Food is mainly composed of water, lipids , proteins , and carbohydrates . Minerals (e.g., salts) and organic substances (e.g., vitamins ) can also be found in food. Plants, algae , and some microorganisms use photosynthesis to make some of their own nutrients. Water
6985-740: The Poaceae (grass) family and pulses coming from the Fabaceae (legume) family. Whole grains are foods that contain all the elements of the original seed (bran, germ, and endosperm ). Nuts are dry fruits, distinguishable by their woody shell. Fleshy fruits (distinguishable from dry fruits like grain, seeds and nuts) can be further classified as stone fruits (cherries and peaches), pome fruits (apples, pears), berries (blackberry, strawberry), citrus (oranges, lemon), melons (watermelon, cantaloupe), Mediterranean fruits (grapes, fig), tropical fruits (banana, pineapple). Vegetables refer to any other part of
7112-567: The Wnt signaling pathway via disruption of members APC (9% of tumors) or CTNNB1 (4% of tumors); or dysregulation of the PI3K pathway via PI3KCA / PI3KCB mutations (6% of tumors) or AKT1 (2% of tumors). Prostate cancer is the second-most frequently diagnosed cancer in men, and the second-most frequent cause of cancer death in men (after lung cancer ). Around 1.2 million new cases of prostate cancer are diagnosed each year, and over 350,000 people die of
7239-504: The food energy required is supplied by the industrial food industry , which produces food through intensive agriculture and distributes it through complex food processing and food distribution systems. This system of conventional agriculture relies heavily on fossil fuels , which means that the food and agricultural systems are one of the major contributors to climate change , accounting for as much as 37% of total greenhouse gas emissions . The food system has significant impacts on
7366-424: The urine or semen , or trouble urinating – commonly including frequent urination and slow or weak urine stream. More than half of men over age 50 experience some form of urination problem, typically due to issues other than prostate cancer such as benign prostatic hyperplasia (non-cancerous enlargement of the prostate). Advanced prostate tumors can metastasize to nearby lymph nodes and bones, particularly in
7493-600: The ACS does not make specific recommendations on dairy food consumption for cancer prevention." It has been suggested that consumption of insulin-like growth factor 1 (IGF-1) in dairy products could increase cancer risk, particularly prostate cancer. However, a 2018 review by the Committee on Carcinogenicity of Chemicals in Food, Consumer Products and the Environment (COC) concluded that there
7620-536: The Cambridge Prognostic Group, with prognostic groups CPG 1 to CPG 5. CPG 1 is the same as AJCC stage I. Cases with localized tumors (T1 or T2) and either Gleason grade group 2 or higher PSA levels (10 to 20 ng/mL) are designated CPG 2. CPG 3 represents either Gleason grade group 3, or the combination of the CPG 2 criteria. CPG 4 is similar to AJCC stage 3 – any of Gleason grade group 4, PSA levels above 20 ng/mL, or
7747-462: The DNA repair-related genes BRCA2 and ATM are rare in localized disease but found in at least 7% and 5% of metastatic disease cases respectively. The transition from castrate-sensitive to castrate-resistant prostate cancer is also accompanied by the acquisition of various gene mutations. In castrate-resistant disease, more than 70% of tumors have mutations in the androgen receptor signaling pathway – amplifications and gain-of-function mutations in
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#17328511093747874-461: The EU, dairy is responsible for 27% of all diet related emissions, on average, while plant-based milks cause 2.5–4.5 times fewer emissions. Food product Food is any substance consumed by an organism for nutritional support. Food is usually of plant, animal, or fungal origin and contains essential nutrients such as carbohydrates , fats , proteins , vitamins , or minerals . The substance
8001-612: The Middle East, and most of Latin America and the Caribbean. Low-consumption countries consume under 30 kg per capita per year. These countries are: Senegal, most of Central Africa, and most of East and Southeast Asia. For those with some degree of lactose intolerance , considering the amount of lactose in dairy products can be important to health. Dairy products may upset the digestive system in individuals with lactose intolerance or
8128-462: The US Food and Drug Administration approved the systemic chemotherapy mitoxantrone for those with castration-resistant prostate cancer based on trials showing that it improved symptoms even though it failed to enhance survival. In 2004, docetaxel was approved as the first chemotherapy to increase survival in those with castration-resistant prostate cancer. After additional trials in 2015, docetaxel use
8255-509: The WHO and CDC , in the USA alone, annually, there are 76 million cases of foodborne illness leading to 325,000 hospitalizations and 5,000 deaths. From 2011 to 2016, on average, there were 668,673 cases of foodborne illness and 21 deaths each year. In addition, during this period, 1,007 food poisoning outbreaks with 30,395 cases of food poisoning were reported. Prostate cancer Prostate cancer
8382-607: The air or water and are the basic nutrients needed for plant survival. The three main nutrients absorbed from the soil for plant growth are nitrogen, phosphorus and potassium, with other important nutrients including calcium, sulfur, magnesium, iron boron, chlorine, manganese, zinc, copper molybdenum and nickel. Bacteria and other microorganisms also form the lower rungs of the food chain. They obtain their energy from photosynthesis or by breaking down dead organisms, waste or chemical compounds. Some form symbiotic relationships with other organisms to obtain their nutrients. Bacteria provide
8509-440: The apex predators, the animals that have no known predators in its ecosystem. Humans are considered apex predators. Humans are omnivores, finding sustenance in vegetables, fruits, cooked meat, milk, eggs, mushrooms and seaweed. Cereal grain is a staple food that provides more food energy worldwide than any other type of crop. Corn (maize) , wheat, and rice account for 87% of all grain production worldwide. Just over half of
8636-418: The average person diagnosed at 67. The average age of those who die from prostate cancer is 77. Only a minority of prostate cancer cases are diagnosed. Autopsies of men who died at various ages have shown cancer in the prostates of over 40% of men over age 50. Incidence rises with age, and nearly 70% of men autopsied at age 80–89 had cancer in their prostates. Prostate cancer is more common in families with
8763-642: The cancer cells disrupt normal body function and continue to grow. Metastases cause most of the discomfort associated with prostate cancer, and can eventually kill the affected person. Most prostate tumors begin in the peripheral zone – the outermost part of the prostate. As cells begin to grow out of control, they form a small clump of disregulated cells called a prostatic intraepithelial neoplasia (PIN). Some PINs continue to grow, forming layers of tissue that stop expressing genes common to their original tissue location – p63 , cytokeratin 5 , and cytokeratin 14 – and instead begin expressing genes typical of cells in
8890-419: The cancer is, the risk it may spread, and the affected person's health and personal preferences. Those with localized disease at low risk for spread are often more likely to be harmed by the side effects of treatment than the disease itself, and so are regularly tested for a worsening of their disease. Those at higher risk may receive treatment to eliminate the tumor – typically prostatectomy (surgery to remove
9017-691: The cancer's grade and stage at the time of diagnosis; those with lower stage disease have vastly improved prognoses. Around 80% of prostate cancer diagnoses are in men whose cancer is still confined to the prostate. These men can survive long after diagnosis, with as many as 99% still alive 10 years from diagnosis. Men whose cancer has metastasized to a nearby part of the body (around 15% of diagnoses) have poorer prognoses, with five-year survival rates of 60–80%. Those with metastases in distant body sites (around 5% of diagnoses) have relatively poor prognoses, with five-year survival rates of 30–40%. Those who have low blood PSA levels at diagnosis, and whose tumors have
9144-428: The composition of dietary patterns toward higher unsaturated to saturated fat ratios that are associated with better cardiovascular health". In 2017, the National Heart Foundation of New Zealand published an umbrella review which found an "overall neutral effect of dairy on cardiovascular risk for the general population". Their position paper stated that "the evidence overall suggests dairy products can be included in
9271-513: The consumption of dairy products. For example, some scholars of Jainism advocate not consuming any dairy products because dairy is perceived to involve violence against cows. Orthodox Judaism requires that meat and dairy products not be served at the same meal, served or cooked in the same utensils, or stored together, as prescribed in Deuteronomy 14:21. Veganism is the avoidance of all animal products, including dairy products, most often due to
9398-455: The development of GnRH agonists, which were found to be as effective as estrogen without the increased risk of clotting. Schally was awarded the 1977 Nobel Prize in Physiology or Medicine for his work on GnRH and prostate cancer. Systemic chemotherapy for prostate cancer has been studied since the 1950s but clinical trials failed to show benefits in most people who receive the drugs. In 1996,
9525-469: The disease, annually. One in eight men are diagnosed with prostate cancer in their lifetime, and around one in forty die of the disease. Rates of prostate cancer rise with age. Due to this, prostate cancer rates are generally higher in parts of the world with higher life expectancy, which also tend to be areas with higher gross domestic product and higher human development index . Australia, Europe, North America, New Zealand, and parts of South America have
9652-468: The disease, called castration-resistant prostate cancer, is treated with continued hormone therapy alongside the chemotherapy drug docetaxel . Some tumors metastasize (spread) to other areas of the body, particularly the bones and lymph nodes . There, tumors cause severe bone pain , leg weakness or paralysis, and eventually death. Prostate cancer prognosis depends on how far the cancer has spread at diagnosis. Most men diagnosed have tumors confined to
9779-419: The disease. Several prostate immortalized cell lines are widely used, namely the classic lines DU145 , PC-3 , and LNCaP , as well as more recent cell lines 22Rv1, LAPC-4 , VCaP , and MDA-PCa-2a and −2b. Research requiring more complex models of the prostate uses organoids – clusters of prostate cells that can be grown from human prostate tumors or stem cells. Modeling tumor growth and metastasis requires
9906-597: The disease; however, detection of cancer cases that would not have otherwise impacted health can cause anxiety, and lead to unneeded biopsies and treatments, both of which can cause unwanted complications. Major national health organizations offer differing recommendations, attempting to balance the benefits of early diagnosis with the potential harms of treating people whose tumors are unlikely to impact health. Most medical guidelines recommend that men at high risk of prostate cancer (due to age, family history, ethnicity, or prior evidence of high blood PSA levels) be counseled on
10033-626: The end of their lives, most experience confusion and may hallucinate or have trouble recognizing loved ones. Confusion is caused by various conditions, including kidney failure , sepsis , dehydration , and as a side effect of various drugs, especially opioids . Most people sleep for long periods, and some feel drowsy when awake. Restlessness is also common, sometimes caused by physical discomfort from constipation or urinary retention , sometimes caused by anxiety. In their last few days, affected men's breathing may become shallow and slow, with long pauses between breaths. Breathing may be accompanied by
10160-567: The essential amino acids that the human body needs. One 4-ounce (110 g) steak, chicken breast or pork chop contains about 30 grams of protein. One large egg has 7 grams of protein. A 4-ounce (110 g) serving of cheese has about 15 grams of protein. And 1 cup of milk has about 8 grams of protein. Other nutrients found in animal products include calories, fat, essential vitamins (including B12) and minerals (including zinc, iron, calcium, magnesium). Food products produced by animals include milk produced by mammary glands , which in many cultures
10287-610: The ethics regarding how dairy products are produced. The ethical reasons for avoiding meat and dairy products include how dairy is produced, how the animals are handled, and the environmental effect of dairy production. According to a report of the United Nations' Food and Agriculture Organization in 2010 the dairy sector accounted for 4 percent of global human-made greenhouse gas emissions. Growing awareness of dairy products' environmental impact, specifically greenhouse gas emissions, has led to many people reducing or avoiding dairy. In
10414-401: The extent of disease, and was easier for surgeons to learn. This was improved upon by Patrick C. Walsh 's 1983 description of a retropubic prostatectomy approach that avoided damage to the nerves near the prostate, preserving erectile function. Radiation therapy for prostate cancer was used occasionally in the early 20th century, with radium implanted into the urethra or rectum to reduce
10541-422: The extent of the tumor (T), spread to any lymph nodes (N), and the presence of metastases (M). Scores of T1 and T2 represent tumors that remain within the prostate: T1 is for tumors not detectable by imaging or digital rectal exam; T2 is for tumors detectable by imaging or rectal exam, but still confined within the prostate. T3 is for tumors that grow beyond the prostate – T3a for tumors with any extension outside
10668-550: The form of starch, fructose, glucose and other sugars. Most vitamins are found from plant sources, with exceptions of vitamin D and vitamin B 12 . Minerals can also be plentiful or not. Fruit can consist of up to 90% water, contain high levels of simple sugars that contribute to their sweet taste, and have a high vitamin C content. Compared to fleshy fruit (excepting Bananas) vegetables are high in starch, potassium , dietary fiber, folate and vitamins and low in fat and calories. Grains are more starch based and nuts have
10795-690: The general population. For people with elevated cholesterol and those with existing coronary heart disease, reduced fat products are recommended." The position statement also noted that the "evidence for milk, yoghurt and cheese does not extend to butter, cream, ice-cream and dairy-based desserts; these products should be avoided in a heart healthy eating pattern". Recent reviews of randomized controlled trials have found that dairy intake from cheese, milk and yogurt does not have detrimental effects on markers of cardiometabolic health. Consumption of dairy products such as low-fat and whole milk have been associated with an increased acne risk, however, as of 2022 there
10922-504: The genome near the oncogene MYC are associated with increased risk. As are single-nucleotide polymorphisms in the vitamin D receptor common in African-Americans, and in the androgen receptor , CYP3A4 , and CYP17 involved in testosterone synthesis and signaling. Together, known gene variants are estimated to cause around 25% of prostate cancer cases, including 40% of early-onset prostate cancers. Men who are taller are at
11049-453: The highest incidence. South Asia, Central Asia, and sub-Saharan Africa have the lowest incidence of prostate cancer; though incidence is increasing quickly in these regions. Prostate cancer is the most diagnosed cancer in men in over half of the world's countries, and the leading cause of cancer death in men in around a quarter of countries. Prostate cancer is rare in those under 40 years old, and most cases occur in those over 60 years, with
11176-504: The innermost lining of the pancreatic duct – cytokeratin 8 and cytokeratin 18 . These multilayered PINs also often overexpress the gene AMACR , which is associated with prostate cancer progression. Some PINs can eventually grow into tumors. This is commonly accompanied by large-scale changes to the genome , with chromosome sequences being rearranged or copied repeatedly. Some genomic alterations are particularly common in early prostate cancer, namely gene fusion between TMPRSS2 and
11303-477: The likelihood that a person will develop aggressive prostate cancer. Many measure "free PSA" – the fraction of PSA unbound to other blood proteins, usually around 10% to 30%. Men who have a lower percentage of free PSA are more likely to have prostate cancer. Several common tests more accurately detect prostate cancer cases by also measuring subtypes of free PSA, including the Prostate Health Index (measures
11430-401: The more severe Gleason score (4) covered more area. A score of 8 is grade group 4. A score of 9 or 10 is grade group 5 (worst prognosis). The extent of cancer spread is assessed by MRI or PSMA scan – a positron emission tomography (PET) imaging technique where a radioactive label that binds the prostate protein prostate-specific membrane antigen is used to detect metastases distant from
11557-415: The most severely cancerous. Gleason scores are commonly grouped into "Gleason grade groups", which predict disease prognosis: a Gleason score of 6 is Gleason grade group 1 (best prognosis). A score of 7 (with Gleason scores 4 + 3, or Gleason scores 3 + 4, with the most prominent listed first) can be grade group 2 or 3; it is grade group 2 if the less severe Gleason score (3) covered more area; grade group 3 if
11684-781: The next 8 to 10 years. Men with PSA levels above 4 ng/mL are at increased risk – around 1 in 4 will develop prostate cancer – and are often referred for a prostate biopsy. PSA levels over 10 ng/mL indicate an even higher risk: over half of men in this group develop prostate cancer. Men with high PSA levels are often recommended to repeat the blood test four to six weeks later, as PSA levels can fluctuate unrelated to prostate cancer. Benign prostatic hyperplasia , prostate infection , recent ejaculation , and some urological procedures can increase PSA levels; taking 5α-reductase inhibitors can decrease PSA levels. Those with elevated PSA may undergo secondary screening blood tests that measure subtypes of PSA and other molecules to better predict
11811-412: The next few months. With either technique, radiation damage to nearby organs can increase the risk of subsequent bladder cancer and cause erectile dysfunction , infertility , irreversible lumbar plexopathy and radiation proctitis – damage to the rectum that can cause diarrhea , bloody stools , fecal incontinence , and pain. Radical prostatectomy aims to surgically remove the cancerous part of
11938-502: The oncogene ERG (up to 60% of prostate tumors), mutations that disable SPOP (up to 15% of tumors), and mutations that hyperactivate FOXA1 (up to 5% of tumors). Metastatic prostate cancer tends to have more genetic mutations than localized disease. Many of these mutations are in genes that protect from DNA damage, such as p53 (mutated in 8% of localized tumors, more than 27% of metastatic ones) and RB1 (1% of localized tumors, more than 5% of metastatic ones). Similarly mutations in
12065-410: The pathologist assigns numbers ranging from 3 (most similar to healthy prostate tissue) to 5 (least similar) to different regions of the biopsied tissue. They then calculate a "Gleason score" by adding the two numbers that represent the largest areas of the biopsy sample. The lowest possible Gleason score of 6 represents a biopsy most similar to healthy prostate; the highest Gleason score of 10 represents
12192-537: The pelvis, hips, spine, ribs, head, and neck. There they can cause fatigue , unexplained weight loss, and back or bone pain that does not improve with rest. Metastases can damage the bones around them, and around a quarter of those with metastatic prostate cancer develop a bone fracture . Growing metastases can also compress the spinal cord causing weakness in the legs and feet, or limb paralysis. Most cases of prostate cancer are diagnosed through screening tests, when tumors are too small to cause any symptoms. This
12319-413: The plant that can be eaten, including roots, stems, leaves, flowers, bark or the entire plant itself. These include root vegetables (potatoes and carrots), bulbs (onion family), flowers (cauliflower and broccoli), leaf vegetables ( spinach and lettuce) and stem vegetables (celery and asparagus ). The carbohydrate, protein and lipid content of plants is highly variable. Carbohydrates are mainly in
12446-614: The primary cause of symptoms and death from metastatic prostate cancer. Those with constant pain are prescribed nonsteroidal anti-inflammatory drugs . However, people with bone metastases can experience "breakthrough pain", sudden bursts of severe pain that resolve within around 15 minutes, before pain medications can take effect. Single sites of pain can be treated with external beam radiation therapy to shrink nearby tumors. More dispersed bone pain can be treated with radioactive compounds that disproportionately accumulate in bone, like radium-223 and samarium-153-EDTMP , which help reduce
12573-496: The prostate are often impossible in women who have undergone vaginoplasty , as the length and rigidity of the new vagina can obstruct access to the prostate from the rectum. A prostate mass was first described in 1817 by the English surgeon George Langstaff , following the autopsy of a man who had died at age 68 with lower-body pain and urinary issues. In 1853, London Hospital surgeon John Adams described another prostate tumor from
12700-402: The prostate for potential tumors in men with high PSA levels. MRI results can help distinguish those who have potentially dangerous tumors from those who do not. A definitive diagnosis of prostate cancer requires a biopsy of the prostate. Prostate biopsies are typically taken by a needle passing through the rectum or perineum , guided by transrectal ultrasonography , MRI, or a combination of
12827-425: The prostate with relatively little radiation to other organs, or by brachytherapy , where a radioactive source is surgically inserted into the prostate. IMRT is given over several sessions, with treatments repeated five days per week for several weeks. Brachytherapy is typically performed in a single session, with the radioactive source permanently implanted into the prostate, where it expends its radioactivity within
12954-802: The prostate) or radiation therapy , sometimes alongside hormone therapy . Those with metastatic disease are treated with chemotherapy , as well as radiation or other agents to alleviate the symptoms of metastatic tumors. Blood PSA levels are monitored every few months to assess the effectiveness of treatments, and whether the disease is recurring or advancing. Men diagnosed with low-risk cases of prostate cancer often defer treatment and are monitored regularly for cancer progression by active surveillance , which involves testing for tumor growth at fixed intervals by PSA tests (around every six months), digital rectal exam (annually), and MRI or repeat biopsies (every one to three years). This program continues until increases in PSA levels, Gleason grade, or tumor size indicate
13081-495: The prostate, along with the seminal vesicles, and the end of the vas deferens (the duct that delivers sperm from the testes). In wealthier countries, this is typically done by robot-assisted surgery , where robotic tools inserted through small holes in the abdomen allow a surgeon to make small and exact movements during surgery. This method results in shorter hospital stays, less blood loss, and fewer complications than traditional open surgery. In places where robot-assisted surgery
13208-482: The prostate. CT scans may also be used, but are less able to detect spread outside the prostate than MRI. Bone scintigraphy is used to test for spread of cancer to bones. After diagnosis, the tumor is staged to determine the extent of its growth and spread. Prostate cancer is typically staged using the American Joint Committee on Cancer 's (AJCC) three-component TNM system , with scores assigned for
13335-562: The prostate. If cancer is present, the pathologist assigns a Gleason score , and a higher score represents a more dangerous tumor. Medical imaging is performed to look for cancer that has spread outside the prostate. Based on the Gleason score, PSA levels, and imaging results, a cancer case is assigned a stage 1 to 4. A higher stage signifies a more advanced, more dangerous disease. Most prostate tumors remain small and cause no health problems. These are managed with active surveillance , monitoring
13462-434: The prostate; 99% of them survive more than 10 years from their diagnoses. Tumors that have metastasized to distant body sites are most dangerous, with five-year survival rates of 30–40%. The risk of developing prostate cancer increases with age; the average age of diagnosis is 67. Those with a family history of any cancer are more likely to have prostate cancer, particularly those who inherit cancer-associated variants of
13589-864: The prostate; T3b for tumors that invade the adjacent seminal vesicles . T4 is for tumors that have grown into organs beyond the seminal vesicles. The N and M scores are binary (yes or no). N1 represents any spread to the nearby lymph nodes. M1 represents any metastases to other body sites. The AJCC then combines the TNM scores, Gleason grade group, and results of the PSA blood test to categorize cancer cases into one of four stages, and their subdivisions. Cancer cases with localized tumors (T1 or T2), no spread (N0 and M0), Gleason grade group 1, and PSA less than 10 ng/mL are designated stage I. Those with localized tumors and PSA between 10 and 20 ng/mL are designated stage II – subdivided into IIA for Gleason grade group 1, IIB for grade group 2, and IIC for grade group 3 or 4. Stage III
13716-487: The receptor gene itself, amplification of its activators (for example, FOXA1), or inactivating mutations in its negative regulators (for example, ZBTB16 and NCOR1 ). These androgen receptor disruptions are only found in up to 6% of biopsies of castrate-sensitive metastatic disease. Similarly, deletions of the tumor suppressor PTEN are harbored by 12–17% of castrate-sensitive tumors, but over 40% of castrate-resistant tumors. Less commonly, tumors have aberrant activation of
13843-420: The removed prostate tissue. Two studies around the time found cancer in as many as 10% of surgical specimens, suggesting prostate cancer was a fairly common cause of prostate enlargement. For much of the 20th century, the primary therapy for prostate cancer was surgery to remove the prostate. Perineal prostatectomy was first performed in 1904 by Hugh H. Young at Johns Hopkins Hospital . Young's method became
13970-409: The rest largely squamous-cell carcinoma (resembling squamous cells , a type of epithelial cell ) and transitional cell carcinoma (resembling transitional cells ). Next, tumor samples are graded based on how much the tumor tissue differs from normal prostate tissue; the more different the tumor appears, the faster the tumor is likely to grow. The Gleason grading system is commonly used, where
14097-527: The risks and benefits of PSA testing, and be offered access to screening tests. Medical guidelines generally recommend against screening for men over age 70, or with a life expectancy of less than 10 years, as a newly diagnosed prostate cancer is unlikely to impact their natural lifespan. Uptake of screening varies by geography – more than 80% of men are screened in the US and Western Europe, 20% of men in Japan, and screening
14224-456: The size of bone tumors. Similarly, the systemic chemotherapeutics used for metastatic prostate cancer can reduce pain as they shrink tumors. Other bone modifying agents like zoledronic acid and denosumab can reduce prostate cancer bone pain, even though they have little effect on tumor size. Metastases compress the spinal cord in up to 12% of those with metastatic prostate cancer causing pain, weakness, numbness, and paralysis. Inflammation in
14351-622: The spine can be treated with high-dose steroids, as well as surgery and radiotherapy to shrink spinal tumors and relieve pressure on the spinal cord. Those with advanced prostate cancer suffer fatigue, lethargy, and a generalized weakness. This is caused in part by gastrointestinal problems, with loss of appetite , weight loss, nausea, and constipation all common. These are typically treated with appetite-increasing drugs – megestrol acetate or corticosteroids – antiemetics , or treatments that focus on underlying gastrointestinal issues. General weakness can also be caused by anemia , itself caused by
14478-1063: The synthesis or action of testosterone , the primary androgen. The first line of treatment typically involves GnRH agonists like leuprolide , goserelin , or triptorelin by injection monthly or less frequently as needed. GnRH agonists cause a brief rise in testosterone levels at treatment initiation, which can worsen disease in people with significant symptoms of metastases. In these people, GnRH antagonists like degarelix or relugolix are given instead, and can also rapidly reduce testosterone levels. Reducing testosterone can cause various side effects, including hot flashes , reduction in muscle mass and bone density, reduced sex drive, fatigue, personality changes, and an increased risk of diabetes, cardiovascular disease, and depression. Hormone therapy halts tumor growth in more than 95% of those treated, and PSA levels return to normal in up to 70%. Despite reduced testosterone levels, metastatic prostate tumors eventually continue to grow – manifested by rising blood PSA levels, and metastases to nearby bones. This
14605-448: The tastes that provide the most energy are the most pleasant to eat while others are not enjoyable, although humans in particular can acquire a preference for some substances which are initially unenjoyable. Water, while important for survival, has no taste. Sweetness is almost always caused by a type of simple sugar such as glucose or fructose , or disaccharides such as sucrose , a molecule combining glucose and fructose. Sourness
14732-459: The testosterone production inhibitor abiraterone acetate . An alternative is the cell therapy procedure Sipuleucel-T , where the affected person's immune cells are removed, treated to more effectively target prostate cancer cells, and re-injected. Tumors that evolve resistance to docetaxel may receive the second-generation taxane drug cabazitaxel . Some CRPC treatments are used only in men whose tumors have certain characteristics that make
14859-530: The therapy more likely to be effective. Men whose tumors express the protein PSMA may receive the radiopharmaceutical Lu-177 PSMA , which binds to and destroys PSMA-positive cells. Those whose tumors have defective DNA damage repair benefit from treatment with the immune checkpoint inhibitor drug pembrolizumab and PARP inhibitors, namely olaparib , rucaparib , or niraparib . Bone metastases – present in around 85% of those with metastatic prostate cancer – are
14986-523: The top. Other aspects of the web include detrovores (that eat detritis ) and decomposers (that break down dead organisms). Primary producers include algae, plants, bacteria and protists that acquire their energy from sunlight. Primary consumers are the herbivores that consume the plants, and secondary consumers are the carnivores that consume those herbivores. Some organisms, including most mammals and birds, diet consists of both animals and plants, and they are considered omnivores. The chain ends with
15113-400: The tumor size and associated symptoms. In the 1950s the advent of more powerful radiation machines allowed for external beam radiotherapy to reach the prostate. By the 1960s, this was often combined with hormone therapy to improve the potency of therapy. In the 1970s, Willet Whitmore pioneered an open surgery technique where needles of Iodine-125 were placed directly into the prostate. This
15240-452: The tumor with regular tests to ensure it has not grown. Tumors more likely to be dangerous can be destroyed with radiation therapy or surgically removed by radical prostatectomy . Those whose cancer spreads beyond the prostate are treated with hormone therapy which reduces levels of the androgens (male sex hormones) that prostate cells need to survive. Eventually cancer cells can grow resistant to this treatment. This most-advanced stage of
15367-500: The two. Ten to twelve samples are taken from several regions of the prostate to improve the chances of finding any tumors. Biopsies are sent for a histopathologic diagnosis of prostate cancer , wherein they are examined under a microscope by a pathologist , who determines the type and extent of cancerous cells present. Cancers are first classified based on their appearance under a microscope. Over 95% of prostate cancers are classified as adenocarcinomas (resembling gland tissue), with
15494-401: The widespread standard, initially done primarily to relieve symptoms of urinary blockage. In 1931 a new surgical method, transurethral resection of the prostate , became available, replacing perineal prostatectomy for symptomatic relief of obstruction. In 1945, Terence Millin described a retropubic prostatectomy approach, which provided easier access to pelvic lymph nodes to assist in staging
15621-403: The world's crops are used to feed humans (55 percent), with 36 percent grown as animal feed and 9 percent for biofuels . Fungi and bacteria are also used in the preparation of fermented foods like bread , wine , cheese and yogurt . During photosynthesis , energy from the sun is absorbed and used to transform water and carbon dioxide in the air or soil into oxygen and glucose. The oxygen
15748-403: Was awarded the 1966 Nobel Prize in Physiology or Medicine for this discovery, the first systemic therapy for prostate cancer. In the 1960s, large studies showed estrogen therapy to be as effective as surgical castration at treating prostate cancer, but that those on estrogen therapy were at increased risk of suffering blood clots . Through the 1980s, Andrzej W. Schally 's studies of GnRH led to
15875-557: Was extended to those with castration-sensitive prostate cancer. Prostate cancer screening and awareness have been widely promoted since the early 2000s by Prostate Cancer Awareness Month in September and Movember in November. However, an analysis of internet searches suggests neither event changes the level of prostate cancer interest or discussion much, in contrast to the more established Breast Cancer Awareness Month . Prostate cancer
16002-691: Was improved upon by Henrik H. Holm in 1983 by using transrectal ultrasound to guide the implantation of radioactive material. The observation that the testicles (and the hormones they secrete) influence prostate size was made as early as the late 18th century via castration experiments in animals. However, occasional experimentation over the next century bore mixed results, likely due to the inability to separate prostate tumors from prostates enlarged due to benign prostatic hyperplasia. In 1941, Charles B. Huggins and Clarence V. Hodges published two studies using surgical castration or oral estrogen to reduce androgen levels and improve prostate cancer symptoms. Huggins
16129-453: Was the primary treatment for prostate cancer. By the mid-20th century, radiation treatments and hormone therapies were developed to improve prostate cancer treatment. The invention of hormone therapies for prostate cancer was recognized with the 1966 Nobel Prize to Charles B. Huggins and the 1977 Prize to Andrzej W. Schally . Early prostate cancer usually causes no symptoms. As the cancer advances, it may cause erectile dysfunction , blood in
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