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150-619: Progressive Era Repression and persecution Anti-war and civil rights movements Contemporary Cabet was born in Dijon , Côte-d'Or , the youngest son of a cooper from Burgundy, Claude Cabet, and his wife Francoise Berthier. He was educated as a lawyer. Cabet married Delphine Lasage on March 25, 1839 at Marylebone , London, during his exile in England, who bore a child. Cabet secured an appointment as attorney-general in Corsica . He represented

300-436: A temperate bacteriophage called CTXφ . Microbiologists have studied the genetic mechanisms by which the V. cholerae bacteria turn off the production of some proteins and turn on the production of other proteins as they respond to the series of chemical environments they encounter, passing through the stomach, through the mucous layer of the small intestine, and on to the intestinal wall. Of particular interest have been

450-434: A utopia in which a democratically elected governing body controlled all economic activity and closely supervised social life. "Icaria" is the name of his fictional country and ideal society. The nuclear family remained the only other independent unit. The book's success prompted Cabet to take steps to realize his Utopia. In 1839, Cabet returned to France to advocate a communitarian social movement , for which he invented

600-501: A "New Nationalism" with active supervision of corporations, higher taxes, and unemployment and old-age insurance. He supported voting rights for women but was silent on civil rights for blacks, who remained in the regular Republican fold. He lost and his new party collapsed, as conservatism dominated the GOP for decades to come. Biographer William Harbaugh argues: Woodrow Wilson gained a national reputation as governor of New Jersey by defeating

750-605: A Center for Icarian Studies, as well as Icarian archives and papers. The Nauvoo Historical Society also has some papers and artifacts on display, and some in the town remember the Icarians during the Labor Day Grape Festival, through a historical play. The connection with grape cultivation is more symbolic than foundational, as the growing of Concord grapes in the Nauvoo area did not begin with the Icarians. It sprang from efforts by

900-523: A French Catholic priest in the 1830s, and expanded in 1846 when Swiss vintner John Tanner brought the Norton grape to the area. However, Baxter's Vineyards and Winery was founded by Icarians Emile and Annette Baxter in 1857, and continues as a 5-generation old family business. It is Illinois' oldest winery. Progressive Era The Progressive Era (1901–1929) was a period in the United States during

1050-541: A blistering indictment of corruption in the US Senate. Roosevelt gave these journalists their nickname when he complained they were not being helpful by raking up too much muck. The progressives were avid modernizers, with a belief in science and technology as the grand solution to society's flaws. They looked to education as the key to bridging the gap between their present wasteful society and technologically enlightened future society. Characteristics of progressivism included

1200-428: A day. Severe cholera, without treatment, kills about half of affected individuals. If the severe diarrhea is not treated, it can result in life-threatening dehydration and electrolyte imbalances. Estimates of the ratio of asymptomatic to symptomatic infections have ranged from 3 to 100. Cholera has been nicknamed the "blue death" because a person's skin may turn bluish-gray from extreme loss of fluids. Fever

1350-433: A favorable attitude toward urban–industrial society, belief in mankind's ability to improve the environment and conditions of life, belief in an obligation to intervene in economic and social affairs, a belief in the ability of experts and in the efficiency of government intervention. Scientific management, as promulgated by Frederick Winslow Taylor , became a watchword for industrial efficiency and elimination of waste, with

1500-428: A greatly reduced pathogen count—though it will not necessarily be perfectly safe, it is an improvement for poor people with limited options. In Bangladesh this practice was found to decrease rates of cholera by nearly half. It involves folding a sari four to eight times. Between uses the cloth should be rinsed in clean water and dried in the sun to kill any bacteria on it. A nylon cloth appears to work as well but

1650-450: A key element of the progressive outlook, as expressed in his Fourteen Points and the League of Nations —an ideal called Wilsonianism . New York Governor Charles Evans Hughes is known for exposing the insurance industry. During his time in office he promoted a range of reforms. As presidential candidate in 1916 he lost after alienating progressive California voters. As Associate Justice of

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1800-527: A massive inoculation program in British India . Persons who survive an episode of cholera have long-lasting immunity for at least 3 years (the period tested.) A number of safe and effective oral vaccines for cholera are available. The World Health Organization (WHO) has three prequalified oral cholera vaccines (OCVs): Dukoral, Sanchol, and Euvichol. Dukoral , an orally administered, inactivated whole-cell vaccine , has an overall efficacy of about 52% during

1950-424: A national audience, and Governor Walter R. Stubbs . According to Gene Clanton's study of Kansas, populism and progressivism have a few similarities but different bases of support. Both opposed corruption and trusts. Populism emerged earlier and came out of the farm community. It was radically egalitarian in favor of the disadvantaged classes. It was weak in the towns and cities except in labor unions. Progressivism, on

2100-573: A network of local organizers loyal to him, and fought for control of the state Republican Party, with mixed success. The Democrats were a minor factor in the state, but he did form coalitions with the active Socialist Party in Milwaukee. He failed to win the nomination for governor in 1896 and 1898 before winning the 1900 gubernatorial election . As governor of Wisconsin, La Follette compiled a progressive record, implementing primary elections and tax reform. La Follette won re-election in 1902 and 1904. In 1905

2250-535: A non-toxic B-subunit of cholera toxin and providing protection against V. cholerae O1; and two vaccines developed using the same transfer of technology—ShanChol (Shantha Biotec) and Euvichol (EuBiologics Co.), which have bivalent O1 and O139 oral killed cholera vaccines. Oral cholera vaccination could be deployed in a diverse range of situations from cholera-endemic areas and locations of humanitarian crises, but no clear consensus exists. Developed for use in Bangladesh ,

2400-408: A one-million fold increase in numbers of V. cholerae in the environment. The source of the contamination is typically other people with cholera when their untreated diarrheal discharge is allowed to get into waterways, groundwater or drinking water supplies. Drinking any contaminated water and eating any foods washed in the water, as well as shellfish living in the affected waterway , can cause

2550-430: A person to contract an infection. Cholera is rarely spread directly from person to person . V. cholerae also exists outside the human body in natural water sources, either by itself or through interacting with phytoplankton , zooplankton , or biotic and abiotic detritus. Drinking such water can also result in the disease, even without prior contamination through fecal matter. Selective pressures exist however in

2700-554: A public uproar that contributed in part to the passage a few months later of the 1906 Pure Food and Drug Act and the Meat Inspection Act . In 1919, he published The Brass Check , a muck-raking exposé of American journalism that publicized the issue of yellow journalism and the limitations of the "free press" in the United States. Four years after publication of The Brass Check , the first code of ethics for journalists

2850-530: A result of transmission by food, while in developing countries it is more often water. Food transmission can occur when people harvest seafood such as oysters in waters infected with sewage , as Vibrio cholerae accumulates in planktonic crustaceans and the oysters eat the zooplankton . People infected with cholera often have diarrhea, and disease transmission may occur if this highly liquid stool, colloquially referred to as "rice-water", contaminates water used by others. A single diarrheal event can cause

3000-421: A severe case if they become infected. Any individual, even a healthy adult in middle age, can undergo a severe case, and each person's case should be measured by the loss of fluids, preferably in consultation with a professional health care provider . The cystic fibrosis genetic mutation known as delta-F508 in humans has been said to maintain a selective heterozygous advantage : heterozygous carriers of

3150-532: A solid agricultural base, as well as shops, three schools, flour and sawmills, a whiskey distillery, English and French newspapers, a 39 piece orchestra, choir, theater, hospital and the state's largest library (4000 volumes). Members met on Saturdays to discuss community affairs and problems, with universal male suffrage; women were allowed to speak but not vote. On Sundays members talked about ethical and moral issues, but there were no denominational religious services, only members had espoused Christianity before joining

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3300-418: A strong federal government. He promoted a strong army and navy and attacked pacifists who thought democracy at home and peace abroad was best served by keeping America weak. Croly was one of the founders of modern liberalism in the United States , especially through his books, essays and a highly influential magazine founded in 1914, The New Republic . In his 1914 book Progressive Democracy , Croly rejected

3450-598: A third party in the state. The third party fell apart in the 1930s, and totally collapsed by 1946. The Wisconsin Idea was the commitment of the University of Wisconsin under President Charles R. Van Hise , with LaFollette support, to use the university's powerful intellectual resources to develop practical progressive reforms for the state and indeed for the nation. Between 1901 and 1911, Progressive Republicans in Wisconsin created

3600-442: A year (uncertainty range: 21,000–143,000) as of 2015 . This occurs mainly in the developing world. In the early 1980s, death rates are believed to have still been higher than three million a year. It is difficult to calculate exact numbers of cases, as many go unreported due to concerns that an outbreak may have a negative impact on the tourism of a country. As of 2004, cholera remained both epidemic and endemic in many areas of

3750-555: A year. To date, seven cholera pandemics have occurred, with the most recent beginning in 1961, and continuing today. The illness is rare in high-income countries , and affects children most severely. Cholera occurs as both outbreaks and chronically in certain areas . Areas with an ongoing risk of disease include Africa and Southeast Asia . The risk of death among those affected is usually less than 5%, given improved treatment, but may be as high as 50% without such access to treatment. Descriptions of cholera are found as early as

3900-596: Is endemic . If people are immunized broadly, herd immunity results, with a decrease in the amount of contamination in the environment. WHO recommends that oral cholera vaccination be considered in areas where the disease is endemic (with seasonal peaks), as part of the response to outbreaks, or in a humanitarian crisis during which the risk of cholera is high. Oral Cholera Vaccine (OCV) has been recognized as an adjunct tool for prevention and control of cholera. The World Health Organization (WHO) has prequalified three bivalent cholera vaccines—Dukoral (SBL Vaccines), containing

4050-547: Is oral rehydration salts (ORS), the replacement of fluids and electrolytes by using slightly sweet and salty solutions. Rice-based solutions are preferred. In children, zinc supplementation has also been found to improve outcomes. In severe cases, intravenous fluids , such as Ringer's lactate , may be required, and antibiotics may be beneficial. The choice of antibiotic is aided by antibiotic sensitivity testing . Cholera continues to affect an estimated 3–5 million people worldwide and causes 28,800–130,000 deaths

4200-422: Is a common problem. Stool and swab samples collected in the acute stage of the disease, before antibiotics have been administered, are the most useful specimens for laboratory diagnosis. If an epidemic of cholera is suspected, the most common causative agent is V. cholerae O1. If V. cholerae serogroup O1 is not isolated, the laboratory should test for V. cholerae O139. However, if neither of these organisms

4350-503: Is a common source. Humans are the only known host for the bacteria . Risk factors for the disease include poor sanitation , insufficient clean drinking water , and poverty . Cholera can be diagnosed by a stool test , or a rapid dipstick test , although the dipstick test is less accurate. Prevention methods against cholera include improved sanitation and access to clean water . Cholera vaccines that are given by mouth provide reasonable protection for about six months, and confer

4500-476: Is an infection of the small intestine by some strains of the bacterium Vibrio cholerae . Symptoms may range from none, to mild, to severe. The classic symptom is large amounts of watery diarrhea lasting a few days. Vomiting and muscle cramps may also occur. Diarrhea can be so severe that it leads within hours to severe dehydration and electrolyte imbalance . This may result in sunken eyes , cold skin, decreased skin elasticity, and wrinkling of

4650-442: Is available to determine the presence of V. cholerae . In those samples that test positive, further testing should be done to determine antibiotic resistance. In epidemic situations, a clinical diagnosis may be made by taking a patient history and doing a brief examination. Treatment via hydration and over-the-counter hydration solutions can be started without or before confirmation by laboratory analysis, especially where cholera

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4800-446: Is effective for adults aged 18–64 as a single dose. One injectable vaccine was found to be effective for two to three years. The protective efficacy was 28% lower in children less than five years old. However, as of 2010 , it has limited availability. Work is under way to investigate the role of mass vaccination. The WHO recommends immunization of high-risk groups, such as children and people with HIV , in countries where this disease

4950-416: Is increasing within cholera bacteria. In Bangladesh , for example, most cases are resistant to tetracycline , trimethoprim-sulfamethoxazole , and erythromycin . Rapid diagnostic assay methods are available for the identification of multi-drug resistant cases. New generation antimicrobials have been discovered which are effective against cholera bacteria in in vitro studies. A rapid dipstick test

5100-424: Is isolated, it is necessary to send stool specimens to a reference laboratory. Infection with V. cholerae O139 should be reported and handled in the same manner as that caused by V. cholerae O1. The associated diarrheal illness should be referred to as cholera and must be reported in the United States. The World Health Organization (WHO) recommends focusing on prevention, preparedness, and response to combat

5250-460: Is less in those with lowered gastric acidity (for instance those using proton pump inhibitors ). Children are also more susceptible, with two- to four-year-olds having the highest rates of infection. Individuals' susceptibility to cholera is also affected by their blood type , with those with type O blood being the most susceptible. Persons with lowered immunity , such as persons with AIDS or malnourished children, are more likely to develop

5400-754: Is maintained. The WHO only recommends antibiotics in those with severe dehydration. Doxycycline is typically used first line, although some strains of V. cholerae have shown resistance . Testing for resistance during an outbreak can help determine appropriate future choices. Other antibiotics proven to be effective include cotrimoxazole , erythromycin , tetracycline , chloramphenicol , and furazolidone . Fluoroquinolones , such as ciprofloxacin , also may be used, but resistance has been reported. Antibiotics improve outcomes in those who are both severely and not severely dehydrated. Azithromycin and tetracycline may work better than doxycycline or ciprofloxacin . In Bangladesh zinc supplementation reduced

5550-469: Is not as affordable. Continued eating speeds the recovery of normal intestinal function. The WHO recommends this generally for cases of diarrhea no matter what the underlying cause. A CDC training manual specifically for cholera states: "Continue to breastfeed your baby if the baby has watery diarrhea, even when traveling to get treatment. Adults and older children should continue to eat frequently." The most common error in caring for patients with cholera

5700-442: Is rapid and thready, and urine output decreases with time. Muscle cramping and weakness, altered consciousness, seizures , or even coma due to electrolyte imbalances are common, especially in children. Cholera bacteria have been found in shellfish and plankton . Transmission is usually through the fecal-oral route of contaminated food or water caused by poor sanitation . Most cholera cases in developed countries are

5850-412: Is rare and should raise suspicion for secondary infection. Patients can be lethargic and might have sunken eyes, dry mouth, cold clammy skin, or wrinkled hands and feet. Kussmaul breathing , a deep and labored breathing pattern, can occur because of acidosis from stool bicarbonate losses and lactic acidosis associated with poor perfusion . Blood pressure drops due to dehydration, peripheral pulse

6000-406: Is rare. For example, the last major outbreak of cholera in the United States occurred in 1910–1911. Cholera is mainly a risk in developing countries in those areas where access to WASH (water, sanitation and hygiene) infrastructure is still inadequate. Effective sanitation practices, if instituted and adhered to in time, are usually sufficient to stop an epidemic. There are several points along

6150-575: Is the preferred solution, often with added potassium. Large volumes and continued replacement until diarrhea has subsided may be needed. Ten percent of a person's body weight in fluid may need to be given in the first two to four hours. This method was first tried on a mass scale during the Bangladesh Liberation War , and was found to have much success. Despite widespread beliefs, fruit juices and commercial fizzy drinks like cola are not ideal for rehydration of people with serious infections of

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6300-404: Is to underestimate the speed and volume of fluids required. In most cases, cholera can be successfully treated with oral rehydration therapy (ORT), which is highly effective, safe, and simple to administer. Rice-based solutions are preferred to glucose-based ones due to greater efficiency. In severe cases with significant dehydration, intravenous rehydration may be necessary. Ringer's lactate

6450-698: The Chamber of Deputies in France as the representative of Côte d'Or , and sat with the extreme radicals. Accused of treason in 1834 because of his bitter attacks on the government both in the history book and subsequently, Cabet was convicted and sentenced to five years' exile. He fled to England and sought political asylum. Influenced by Robert Owen , Thomas More and Charles Fourier , Cabet wrote Voyage et aventures de lord William Carisdall en Icarie ("Travel and Adventures of Lord William Carisdall in Icaria", 1840), which depicted

6600-446: The Gs alpha subunit of the heterotrimeric G protein . This results in constitutive cAMP production, which in turn leads to the secretion of water, sodium, potassium, and bicarbonate into the lumen of the small intestine and rapid dehydration. The gene encoding the cholera toxin was introduced into V. cholerae by horizontal gene transfer . Virulent strains of V. cholerae carry a variant of

6750-575: The Mississippi River to Nauvoo, Illinois , where they purchased twelve acres recently vacated by the Mormons in 1849. Cabet was unanimously elected leader, for a one-year term. The improved location enabled the experiment to develop into a successful agricultural community. Education and culture were highly valued by members. By 1855, the Nauvoo Icarian community had expanded to about 500 members with

6900-561: The Nineteenth Amendment until 1971, Progressive reformers like Gertrude Weil and Dr. Elizabeth Delia Dixon Carroll lobbied for woman suffrage . Following the Wilmington massacre , North Carolina imposed strict legal segregation and rewrote its constitution in order to disfranchise Black men through poll taxes and literacy tests. In the Black community, Charlotte Hawkins Brown built

7050-666: The Palmer Memorial Institute to provide a liberal arts education to Black children and promote excellence and leadership. Brown worked with Booker T. Washington (in his role with the National Negro Business League ), who provided ideas and access to Northern philanthropy. Apart from Wisconsin, the Midwestern states were about average in supporting Progressive reforms. Ohio took the lead in municipal reform. The negative effects of industrialization triggered

7200-662: The Panama Canal . He expanded the army and sent the Great White Fleet on a world tour to project the United States naval power around the globe. His successful efforts to broker the end of the Russo-Japanese War won him the 1906 Nobel Peace Prize. He avoided controversial tariff and money issues. He was elected to a full term in 1904 and continued to promote progressive policies, some of which were passed in Congress. By 1906 he

7350-483: The Pure Food and Drug Act . The journalists who specialized in exposing waste, corruption, and scandal operated at the state and local level, like Ray Stannard Baker , George Creel , and Brand Whitlock . Others such as Lincoln Steffens exposed political corruption in many large cities; Ida Tarbell is famed for her criticisms of John D. Rockefeller 's Standard Oil Company . In 1906, David Graham Phillips unleashed

7500-653: The United States to organize an Icarian community. They entered into a social contract, making Cabet the director-in-chief for the first ten years, and embarked from Le Havre , February 3, 1848, for New Orleans, Louisiana . They expected to settle in the Red River valley in Texas . However, the Peters Land Company gave them deeds to only 320 acres of land in Denton County, Texas near what became Dallas, Texas rather than

7650-406: The human stomach . The few surviving bacteria conserve their energy and stored nutrients during the passage through the stomach by shutting down protein production. When the surviving bacteria exit the stomach and reach the small intestine , they must propel themselves through the thick mucus that lines the small intestine to reach the intestinal walls where they can attach and thrive. Once

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7800-479: The potassium level may be normal, even though large losses have occurred. As the dehydration is corrected, potassium levels may decrease rapidly, and thus need to be replaced. This is best done by Oral Rehydration Solution (ORS). Antibiotic treatments for one to three days shorten the course of the disease and reduce the severity of the symptoms. Use of antibiotics also reduces fluid requirements. People will recover without them, however, if sufficient hydration

7950-524: The "community chest" movement. The American Red Cross was reorganized and professionalized. Several major foundations aided the blacks in the South and were typically advised by Booker T. Washington . By contrast, Europe and Asia had few foundations. This allowed both Carnegie and Rockefeller to operate internationally with a powerful effect. A hallmark group of the Progressive Era, the middle class became

8100-411: The "sari filter" is a simple and cost-effective appropriate technology method for reducing the contamination of drinking water. Used sari cloth is preferable but other types of used cloth can be used with some effect, though the effectiveness will vary significantly. Used cloth is more effective than new cloth, as the repeated washing reduces the space between the fibers. Water collected in this way has

8250-544: The 1895 case of United States v. E. C. Knight Co. As Chief Justice of the Supreme Court he took a moderate middle position and upheld key New Deal laws. Gifford Pinchot was an American forester and politician. Pinchot served as the first Chief of the United States Forest Service from 1905 until 1910 and was the 28th Governor of Pennsylvania , serving from 1923 to 1927, and again from 1931 to 1935. He

8400-452: The 5th century BC in Sanskrit . In Europe, cholera was a term initially used to describe any kind of gastroenteritis, and was not used for this disease until the early 19th century. The study of cholera in England by John Snow between 1849 and 1854 led to significant advances in the field of epidemiology because of his insights about transmission via contaminated water, and a map of the same

8550-819: The American Civil War) and two families rejoined the Icarians in Corning, Iowa discussed below (the Cheltenham area became a neighborhood within St. Louis). Before his death, Cabet sued the Nauvoo Icarians in a local court, as well as petitioned the Illinois legislature to repeal the act that incorporated the community. The Nauvoo colony relocated to Corning , Adams County, Iowa , about 80 miles southwest of Des Moines, Iowa between 1858 and 1860, because of Illinois crop failures as well as

8700-872: The People's Power League. The group led efforts in Oregon to establish an initiative and referendum system, allowing direct legislation by the state's citizens. In 1902, the Oregon Legislative Assembly approved such a system, which was known at the time as the " Oregon System ". The group's further efforts led to successful ballot initiatives implementing a direct primary system in 1904, and allowing citizens to directly recall public officials in 1908. Democrats who promoted progressive policies included George Earle Chamberlain (governor 1903–1909 and senator 1909–1921); Oswald West (governor 1911–1915); and Harry Lane (senator 1913–1917). The most important Republican

8850-589: The Republican Party and if frustrated trying third-party activity especially in 1924 and the 1930s. Secondly the Wisconsin idea , of intellectuals and planners based at the University of Wisconsin shaping government policy. LaFollette started as a traditional Republican in the 1890s, where he fought against populism and other radical movements. He broke decisively with the state Republican leadership, and took control of

9000-520: The Supreme Court, he often sided with Oliver Wendell Holmes in upholding popular reforms such as the minimum wage, workmen's compensation, and maximum work hours for women and children. He also wrote several opinions upholding the power of Congress to regulate interstate commerce under the Commerce Clause . His majority opinion in the Baltimore and Ohio Railroad v. Interstate Commerce Commission upheld

9150-510: The West. He called for government ownership of railroads and electric utilities, cheap credit for farmers, stronger laws to help labor unions, and protections for civil liberties. La Follette won 17% of the popular vote and carried only his home state in the face of a Republican landslide. After his death in 1925 his sons, Robert M. La Follette Jr. and Philip La Follette , succeeded him as progressive leaders in Wisconsin. President Theodore Roosevelt

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9300-508: The above-mentioned book on Christianity. There were probably 400,000 adherents of the Icarian school. In 1847, after realizing the economic hardship caused by the depression of 1846, Cabet gave up on the notion of reforming French society. Instead, after conversations with Robert Owen and Owen's attempts to found a commune in Texas, Cabet gathered a group of followers from across France and traveled to

9450-561: The added benefit of protecting against another type of diarrhea caused by E. coli . In 2017, the US Food and Drug Administration (FDA) approved a single-dose, live, oral cholera vaccine called Vaxchora for adults aged 18–64 who are travelling to an area of active cholera transmission. It offers limited protection to young children. People who survive an episode of cholera have long-lasting immunity for at least three years (the period tested). The primary treatment for affected individuals

9600-474: The aquatic environment that may reduce the virulence of V. cholerae . Specifically, animal models indicate that the transcriptional profile of the pathogen changes as it prepares to enter an aquatic environment. This transcriptional change results in a loss of ability of V. cholerae to be cultured on standard media, a phenotype referred to as ' viable but non-culturable ' (VBNC) or more conservatively ' active but non-culturable ' (ABNC). One study indicates that

9750-907: The beginning of the age of mass media, the rapid expansion of national advertising led the cover price of popular magazines to fall sharply to about 10 cents, lessening the financial barrier to consume them. Another factor contributing to the dramatic upswing in magazine circulation was the prominent coverage of corruption in politics, local government, and big business, particularly by journalists and writers who became known as muckrakers . They wrote for popular magazines to expose social and political sins and shortcomings. Relying on their own investigative journalism , muckrakers often worked to expose social ills and corporate and political corruption . Muckraking magazines, notably McClure's , took on corporate monopolies and political machines while raising public awareness of chronic urban poverty, unsafe working conditions, and social issues like child labor . Most of

9900-441: The bosses and pushing through a progressive agenda. As president he introduced a comprehensive program of domestic legislation. He had four major domestic priorities: the conservation of natural resources, banking reform, tariff reduction , and opening access to raw materials by breaking up Western mining trusts. Though foreign affairs would unexpectedly dominate his presidency, Wilson's first two years in office largely focused on

10050-525: The campaign for inclusion of the initiative and referendum in the state's constitution. The League sent questionnaires to prospective candidates to the state legislature to obtain their stance on direct legislation and to make those positions public. It then flooded the state with letters seeking new members, money, and endorsements from organizations like the State Federation of Labor. As membership grew it worked with other private organizations to petition

10200-400: The cause of prohibition, leading North Carolina to become the first southern state to implement statewide prohibition . Progressives worked to limit child labor in textile mills and supported public health campaigns to eradicate hookworm and other debilitating diseases. While the majority of North Carolininans continued to support traditional gender roles, and state legislators did not ratify

10350-422: The cholera bacteria reach the intestinal wall, they no longer need the flagella to move. The bacteria stop producing the protein flagellin to conserve energy and nutrients by changing the mix of proteins that they express in response to the changed chemical surroundings. On reaching the intestinal wall, V. cholerae start producing the toxic proteins that give the infected person a watery diarrhea. This carries

10500-612: The cholera transmission path at which its spread may be halted: Handwashing with soap or ash after using a toilet and before handling food or eating is also recommended for cholera prevention by WHO Africa. Surveillance and prompt reporting allow for containing cholera epidemics rapidly. Cholera exists as a seasonal disease in many endemic countries, occurring annually mostly during rainy seasons . Surveillance systems can provide early alerts to outbreaks, therefore leading to coordinated response and assist in preparation of preparedness plans. Efficient surveillance systems can also improve

10650-490: The citizens who are most vulnerable and deprived. In the south, prohibition was high on the agenda but controversial. Jim Crow and disenfranchisement of Black voters was even higher on the agenda. In the Western states, woman suffrage was a success story, but racist anti-Asian sentiment also prevailed. The Oregon Direct Legislation League was an organization of political activists founded by William S. U'Ren in 1898. Oregon

10800-543: The communal dining hall. Although the colony by then had 526 members and 57 more across the Mississippi River at Montrose, Iowa , it was suffering economically—dependent upon money brought by new members and subsidies from the "Le Populaire" home office in France. Moreover, split regarding the work division and food distribution worsened during the summer and following year. Cabet published his final book, Colonie icarienne aux États-Unis d'Amérique (1856), but that failed to solve

10950-822: The community. Based on this success, some even considered expanding the community 200 miles west to Adair County, Iowa . However, Cabet was forced to return to France in May 1851 to settle charges of fraud brought up by his previous followers in Europe. Although found not guilty by a French jury in July 1851, when Cabet returned to Nauvoo in July 1852, the community had changed. Some men were using tobacco and abusing alcohol, many women were adorning themselves with fancy dresses and jewelry, and families claimed land as private property. Cabet responded by issuing "Forty-Eight Rules of Conduct" on November 23, 1853, forbidding "tobacco, hard liquor, complaints about

11100-482: The conservation of forests high on America's priority list. Herbert Croly was an intellectual leader of the movement as an editor, political philosopher and a co-founder of the magazine The New Republic . His political philosophy influenced many leading progressives including Theodore Roosevelt, Adolph Berle , as well as his close friends Judge Learned Hand and Supreme Court Justice Felix Frankfurter . Croly's 1909 book The Promise of American Life looked to

11250-523: The conservatives (called "Stalwarts") to elect Emanuel Philipp as governor in 1914. The Stalwart counterattack said the Progressives were too haughty, too beholden to experts, too eager to regulate, and too expensive. Economy and budget cutting was their formula. The progressive Wisconsin Idea promoted the use of the University of Wisconsin faculty as intellectual resources for state government, and as guides for local government. It promoted expansion of

11400-427: The constitutional liberalism as espoused by Alexander Hamilton , combined with the radical democracy of Thomas Jefferson . The book influenced contemporaneous progressive thought, shaping the ideas of many intellectuals and political leaders, including then ex-President Theodore Roosevelt. Calling themselves "The New Nationalists", Croly and Walter Weyl sought to remedy the relatively weak national institutions with

11550-424: The culturability of V. cholerae drops 90% within 24 hours of entering the water, and furthermore that this loss in culturability is associated with a loss in virulence. Both toxic and non-toxic strains exist. Non-toxic strains can acquire toxicity through a temperate bacteriophage . About 100   million bacteria must typically be ingested to cause cholera in a normal healthy adult. This dose, however,

11700-524: The driving force behind much of the thought and reform that took place in this time. With an increasing disdain for the upper class and aristocracy of the time, the middle class is characterized by their rejection of the individualistic philosophy of the Upper Ten . They had a rapidly growing interest in the communication and role between classes, those of which are generally referred to as the upper class, working class, farmers, and themselves. Along these lines,

11850-433: The duration and severity of diarrhea in children with cholera when given with antibiotics and rehydration therapy as needed. It reduced the length of disease by eight hours and the amount of diarrhea stool by 10%. Supplementation appears to be also effective in both treating and preventing infectious diarrhea due to other causes among children in the developing world. If people with cholera are treated quickly and properly,

12000-603: The early 20th century of widespread social activism and political reform across the country. Progressives sought to address the problems caused by rapid industrialization, urbanization, immigration, and political corruption as well as the enormous concentration of industrial ownership in monopolies. Progressive reformers were alarmed by the spread of slums, poverty, and the exploitation of labor. Multiple overlapping progressive movements fought perceived social, political, and economic ills by advancing good democracy, scientific methods, and professionalism; regulating business; protecting

12150-413: The early 20th century, American philanthropy matured, with the development of very large, highly visible private foundations created by Rockefeller and Carnegie. The largest foundations fostered modern, efficient, business-oriented operations (as opposed to "charity") designed to better society rather than merely enhance the status of the giver. Close ties were built with the local business community, as in

12300-672: The end of financial support from France following the Panic of 1857 . The Corning Icarians prospered until another factional split in 1878, prompted by new emigrants from France, who left to establish a community in Cloverdale, California in 1883 (but "Icaria Speranza" lasted only four years). The colony at Corning disbanded in 1898, but by that time it had existed for 46 years, making it the longest non-religious communal living experiment in American history. The library at Western Illinois University has

12450-438: The first to immunize humans against a bacterial disease. His vaccine and inoculation was rather controversial and was rejected by his peers and several investigation commissions but it ended up demonstrating its effectiveness and being recognized for it: out of the 30 thousand people he vaccinated only 54 died. Russian-Jewish bacteriologist Waldemar Haffkine also developed a human cholera vaccine in July 1892. He conducted

12600-475: The first year after being given and 62% in the second year, with minimal side effects. It is available in over 60 countries. However, it is not currently recommended by the Centers for Disease Control and Prevention (CDC) for most people traveling from the United States to endemic countries. The vaccine that the US Food and Drug Administration (FDA) recommends, Vaxchora , is an oral attenuated live vaccine , that

12750-449: The food, and hunting and fishing 'for pleasure'" as well as demanding absolute silence in workshops and submission to him. Some described him as authoritarian or emotionally unstable; internal problems arose and worsened. In the spring of 1855, Cabet tried to revise the colony's constitution to make him president for life, but was instead relieved of the presidency, so his followers went out on strike, and were in turn temporarily barred from

12900-406: The founder of Hull-House , Jane Addams , coined the term "association" as a counter to Individualism , with association referring to the search for a relationship between the classes. Additionally, the middle class (most notably women) began to move away from prior Victorian era domestic values. Divorce rates increased as women preferred to seek education and freedom from the home. Victorianism

13050-564: The founder of the social work profession in the United States. Maurice Hamington considered her a radical pragmatist and the first woman "public philosopher" in the United States. In the 1930s, she was the best-known female public figure in the United States. According to James Wright, the typical progressive agenda at the state level included: A reduction of corporate influence, open processes of government and politics, equity entrance in taxation, efficiency in government mental operation, and an expanded, albeit limited, state responsibility to

13200-420: The genetic mechanisms by which cholera bacteria turn on the protein production of the toxins that interact with host cell mechanisms to pump chloride ions into the small intestine, creating an ionic pressure which prevents sodium ions from entering the cell. The chloride and sodium ions create a salt-water environment in the small intestines, which through osmosis can pull up to six liters of water per day through

13350-457: The genetic structure. Two clusters have been identified: Cluster I and Cluster II. For the most part, Cluster I consists of strains from the 1960s and 1970s, while Cluster II largely contains strains from the 1980s and 1990s, based on the change in the clone structure. This grouping of strains is best seen in the strains from the African continent. In many areas of the world, antibiotic resistance

13500-459: The government of Louis Philippe , despite having headed an insurrectionary committee during the July Revolution of 1830 which led to the ouster of the "Republican Monarch" King Charles X (and the ascent of Louis Philippe). However, Cabet lost this position for his attack upon the conservatism of the government in his Histoire de la révolution de 1830 . Nonetheless, in 1831, Cabet was elected to

13650-401: The hands and feet. Dehydration can cause the skin to turn bluish . Symptoms start two hours to five days after exposure. Cholera is caused by a number of types of Vibrio cholerae , with some types producing more severe disease than others. It is spread mostly by unsafe water and unsafe food that has been contaminated with human feces containing the bacteria. Undercooked shellfish

13800-439: The highest selling books of the late 1800s. It helped spark the Progressive Era and a worldwide social reform movement around an ideology now known as Georgism . Jacob Riis , for example, explicitly marks the beginning of the Progressive Era awakening as 1879 because of the date of this publication. Magazines experienced a boost in popularity in 1900, with some attaining circulations in the hundreds of thousands of subscribers. In

13950-454: The implementation of his New Freedom domestic agenda. Wilson presided over the passage of his progressive New Freedom domestic agenda. His first major priority was the passage of the Revenue Act of 1913 , which lowered tariffs and implemented a federal income tax . Later tax acts implemented a federal estate tax and raised the top income tax rate to 77 percent. Wilson also presided over

14100-458: The initiative would give political power to the working class and reduce the need for strikes. Sullivan's book was first widely read on the left, as by labor activists, socialists and populists. William U'Ren was an early convert who used it to build the Oregon reform crusade. By 1900, middle-class "progressive" reformers everywhere were studying it. Progress and Poverty , Henry George 's first book, sold several million copies, becoming one of

14250-456: The internal problems. In October 1856, about 180 supporters and Cabet left Nauvoo in three groups for New Bremen, Missouri near St. Louis , Missouri . Cabet suffered a stroke on November 8, 1856, a few days after moving to Missouri with the last group of his followers, and soon died. He was buried at the Old Picker's Cemetery, but his remains were moved during construction of a high school on

14400-463: The intestinal cells, creating the massive amounts of diarrhea. The host can become rapidly dehydrated unless treated properly. By inserting separate, successive sections of V. cholerae DNA into the DNA of other bacteria, such as E. coli that would not naturally produce the protein toxins, researchers have investigated the mechanisms by which V. cholerae responds to the changing chemical environments of

14550-400: The intestines, and their excessive sugar content may even harm water uptake. If commercially produced oral rehydration solutions are too expensive or difficult to obtain, solutions can be made. One such recipe calls for 1 liter of boiled water, 1/2 teaspoon of salt, 6 teaspoons of sugar, and added mashed banana for potassium and to improve taste. As there frequently is initially acidosis ,

14700-557: The key role. The Stalwarts counterattacked by arguing if the university became embedded in the state, then its internal affairs became fair game, especially the faculty preference for advanced research over undergraduate teaching. The Stalwarts controlled the Regents, and their interference in academic freedom outraged the faculty. Historian Frederick Jackson Turner , the most famous professor, quit and went to Harvard. State leaders in reform included editor William Allen White , who reached

14850-532: The large German and Scandinavian elements which demanded neutrality in the World War I. He finally ran an independent campaign for president in 1924 that appealed to the German Americans, labor unions, socialists, and more radical reformers. He won 1/6 of the national vote, but carried only his home state. After his death in 1925 his two sons took over the party. They serve terms as governor and senator and set up

15000-529: The latter. In it, Cabet argued that the kingdom of God announced by Jesus was nothing other than a communist society. The book also contained a popular history of the French Revolutions from 1789 to 1830. In 1841 Cabet revived the Populaire (founded by him in 1833), which was widely read by French workingmen, and from 1843 to 1847 he printed an Icarian almanac, a number of controversial pamphlets as well as

15150-527: The legislature elected him to the United States Senate, where he emerged as a national progressive leader, often clashing with conservatives like Senator Nelson Aldrich . He initially supported President Taft, but broke with Taft after the latter failed to push a reduction in tariff rates. He challenged Taft for the Republican presidential nomination in the 1912 presidential election , but his candidacy

15300-525: The million acres of land in the Red River Valley they expected (more than 200 miles away). The first group of emigrants ultimately returned to New Orleans; Cabet came later at the head of a second and smaller band. Neither Texas nor Louisiana proved the looked-for Utopia, and, ravaged by disease, about one-third of the colonists returned to France. The remainder (142 men, 74 women and 64 children, although 20 died of cholera en route), moved northward along

15450-497: The mortality rate is less than 1%; however, with untreated cholera, the mortality rate rises to 50–60%. For certain genetic strains of cholera, such as the one present during the 2010 epidemic in Haiti and the 2004 outbreak in India, death can occur within two hours of becoming ill. Cholera affects an estimated 2.8 million people worldwide, and causes approximately 95,000 deaths

15600-601: The most famous leader of Midwestern progressivism, began his career by winning election against his state's Republican party in 1900. The machine was temporarily defeated, allowing reformers to launch the " Wisconsin idea " of expanded democracy. This idea included major reforms such as direct primaries, campaign finance, civil service, anti-lobbying laws, state income and inheritance taxes, child labor restrictions, pure food, and workmen's compensation laws. La Follette promoted government regulation of railroads, public utilities, factories, and banks. Although La Follette lost influence in

15750-406: The movement operated chiefly at the local level, but later it expanded to the state and national levels. Progressive leaders were often from the educated middle class, and various progressive reform efforts drew support from lawyers, teachers, physicians, ministers, business people, and the working class. Certain key groups of thinkers, writers, and activists played key roles in creating or building

15900-582: The movements and ideas that came to define the shape of the Progressive Era. Inspiration for the initiative movement was based on the Swiss experience. New Jersey labor activist James W. Sullivan visited Switzerland in 1888 and wrote a detailed book that became a template for reformers pushing the idea: Direct Legislation by the Citizenship Through the Initiative and Referendum (1893). He suggested that using

16050-475: The muckrakers wrote nonfiction, but fictional exposés often had a major impact as well, such as those by Upton Sinclair . In his 1906 novel The Jungle , Sinclair exposed the unsanitary and inhumane practices of the meatpacking industry, as he made clear in the Jungle itself. He quipped, "I aimed at the public's heart and by accident, I hit it in the stomach," as readers demanded and got the Meat Inspection Act and

16200-448: The multiplying new generations of V. cholerae bacteria out into the drinking water of the next host if proper sanitation measures are not in place. The cholera toxin (CTX or CT) is an oligomeric complex made up of six protein subunits : a single copy of the A subunit (part A), and five copies of the B subunit (part B), connected by a disulfide bond . The five B subunits form a five-membered ring that binds to GM1 gangliosides on

16350-400: The mutation (who are not affected by cystic fibrosis) are more resistant to V. cholerae infections. In this model, the genetic deficiency in the cystic fibrosis transmembrane conductance regulator channel proteins interferes with bacteria binding to the intestinal epithelium , thus reducing the effects of an infection. When consumed, most bacteria do not survive the acidic conditions of

16500-405: The nation's first comprehensive statewide primary election system, the first effective workplace injury compensation law, and the first state income tax , making taxation proportional to actual earnings. The key leaders were Robert M. La Follette and (in 1910) Governor Francis E. McGovern . However, in 1912 McGovern supported Roosevelt for president and LaFollette was outraged. He made sure

16650-490: The national party in 1912, the Wisconsin reforms became a model for national progressivism. Wisconsin from 1900 to the late 1930s was a regional and national model for innovation and organization in the progressive movement. The direct primary made it possible to mobilize voters against the previously dominant political machines. The first factors involved the La Follette family going back and forth between trying to control of

16800-403: The natural environment; and improving working and living conditions of the urban poor. Corrupt and undemocratic political machines and their bosses were a major target of progressive reformers. To revitalize democracy, progressives established direct primary elections , direct election of senators (rather than by state legislatures), initiatives and referenda , and women's suffrage which

16950-511: The next legislature defeated the governor's programs, and that McGovern was defeated in his bid for the Senate in 1914. The Progressive movement split into hostile factions. Some was based on personalities—especially La Follette's style of violent personal attacks against other Progressives, and some was based on who should pay, with the division between farmers (who paid property taxes) and the urban element (which paid income taxes). This disarray enabled

17100-495: The other hand, was a later movement. It emerged after the 1890s from the urban business and professional communities. Most of its activists had opposed populism. It was elitist, and emphasized education and expertise. Its goals were to enhance efficiency, reduce waste, and enlarge the opportunities for upward social mobility. However, some former Populists changed their emphasis after 1900 and supported progressive reforms. Cholera Cholera ( / ˈ k ɒ l ər ə / )

17250-624: The party by 1900, all the time quarreling endlessly with ex-allies. The Democrats were a minor conservative factor in Wisconsin. The Socialists, with a strong German and union base in Milwaukee, joined the progressives in statewide politics. Senator Robert M. La Follette tried to use his national reputation to challenge President Taft for the Republican nomination in 1912. However, as soon as Roosevelt declared his candidacy, most of La Follette's supporters switched away. La Follette supported many of his Wilson's domestic programs in Congress. However he strongly opposed Wilson's foreign policy, and mobilized

17400-671: The passage of the Federal Reserve Act , which created a central banking system in the form of the Federal Reserve System . Two major laws, the Federal Trade Commission Act and the Clayton Antitrust Act , were passed to regulate business and prevent monopolies. Wilson did not support civil rights and did not object to accelerating segregate of federal employees. In World War I, he made internationalism

17550-767: The political movement of progressivism, which aimed to address its negative consequences through social reform and government regulation. Jane Addams and Ellen Gates Starr pioneered the settlement house outreach to newly arrived immigrants by establishing Hull House in Chicago in 1889. Settlement houses provided social services and played an active role in civic life, helping immigrants prepare for naturalization and campaigning for regulation and services from city government. Midwestern mayors—especially Hazen S. Pingree and Tom L. Johnson , led early reforms against boss-dominated municipal politics, while Samuel M. Jones advocated public ownership of local utilities. Robert M. La Follette ,

17700-579: The right of the federal government to regulate the hours of railroad workers. His majority opinion in the 1914 Shreveport Rate Case upheld a decision by the Interstate Commerce Commission to void discriminatory railroad rates imposed by the Railroad Commission of Texas . The decision established that the federal government could regulate intrastate commerce when it affected interstate commerce, though Hughes avoided directly overruling

17850-399: The risk assessment for potential cholera outbreaks. Understanding the seasonality and location of outbreaks provides guidance for improving cholera control activities for the most vulnerable. For prevention to be effective, it is important that cases be reported to national health authorities. Spanish physician Jaume Ferran i Clua developed the first successful cholera inoculation in 1885,

18000-585: The site , and now rest at New Saint Marcus Cemetery and Mausoleum in Affton , St. Louis County, Missouri , with a gravestone funded by the French Embassy. On February 15, 1858, the remaining Icarians settled in Cheltenham on the western edge of St. Louis, under the leadership of a lawyer named Mercadier, whom Cabet had designated as his successor. That colony would disband in 1864 (with several young men fighting in

18150-406: The spread of cholera. They also stress the importance of an effective surveillance system. Governments can play a role in all of these areas. Although cholera may be life-threatening, prevention of the disease is normally straightforward if proper sanitation practices are followed. In developed countries , due to their nearly universal advanced water treatment and sanitation practices, cholera

18300-586: The state legislature, which was not responsive. In 1902 the League won a state constitutional amendment establishing direct democracy at the local level, and in 1904, it successfully engineered the recall of the first public official. Progressivism was strongest in the cities, but the South was rural with few large cities. Nevertheless, statewide progressive movements were organized by Democrats in every Southern state. Furthermore, Southern Democrats in Congress gave strong support to President Wilson's reforms. The South

18450-514: The state university system and improvements in transportation, which earned it the nickname "The Good Roads State." State leaders included Governor Charles B. Aycock , who led both the educational and the white supremacy crusades; diplomat Walter Hines Page ; and educator Charles Duncan McIver . Women were especially active through the WCTU , the Baptist church, overseas missions, local public schools, and in

18600-632: The stomach, mucous layers, and intestinal wall. Researchers have discovered a complex cascade of regulatory proteins controls expression of V. cholerae virulence determinants. In responding to the chemical environment at the intestinal wall, the V. cholerae bacteria produce the TcpP/TcpH proteins, which, together with the ToxR/ToxS proteins, activate the expression of the ToxT regulatory protein. ToxT then directly activates expression of virulence genes that produce

18750-470: The stopwatch as its symbol. The number of rich families climbed exponentially, from 100 or so millionaires in the 1870s to 4,000 in 1892 and 16,000 in 1916. Many subscribed to Andrew Carnegie 's credo outlined in The Gospel of Wealth that said they owed a duty to society that called for philanthropic giving to colleges, hospitals, medical research, libraries, museums, religion, and social betterment. In

18900-607: The surface of the intestinal epithelium cells. The A1 portion of the A subunit is an enzyme that ADP-ribosylates G proteins , while the A2 chain fits into the central pore of the B subunit ring. Upon binding, the complex is taken into the cell via receptor-mediated endocytosis . Once inside the cell, the disulfide bond is reduced, and the A1 subunit is freed to bind with a human partner protein called ADP-ribosylation factor 6 (Arf6). Binding exposes its active site, allowing it to permanently ribosylate

19050-401: The term communisme . Some writers ignored Cabet's Christian influences , as described in his book Le vrai christianisme suivant Jésus Christ ("The real Christianity according to Jesus Christ", in five volumes, 1846). This book described Christ's mission to be to establish social equality , and contrasted primitive Christianity with the ecclesiasticism of Cabet's time to the disparagement of

19200-409: The term conservation ethic as applied to natural resources. Pinchot's main contribution was his leadership in promoting scientific forestry and emphasizing the controlled, profitable use of forests and other natural resources so they would be of maximum benefit to mankind. He was the first to demonstrate the practicality and profitability of managing forests for continuous cropping. His leadership put

19350-658: The thesis that the liberal tradition in the United States was inhospitable to anti-capitalist alternatives. He drew from the American past a history of resistance to capitalist wage relations that was fundamentally liberal, and he reclaimed an idea that progressives had allowed to lapse—that working for wages was a lesser form of liberty. Increasingly skeptical of the capacity of social welfare legislation to remedy social ills, Croly argued that America's liberal promise could be redeemed only by syndicalist reforms involving workplace democracy . His liberal goals were part of his commitment to American republicanism . Upton Sinclair

19500-410: The toxins, causing diarrhea in the infected person and allowing the bacteria to colonize the intestine. Current research aims at discovering "the signal that makes the cholera bacteria stop swimming and start to colonize (that is, adhere to the cells of) the small intestine." Amplified fragment length polymorphism fingerprinting of the pandemic isolates of V. cholerae has revealed variation in

19650-551: The university through the UW-Extension system to reach all the state's farming communities. University economics professors John R. Commons and Harold Groves enabled Wisconsin to create the first unemployment compensation program in the United States in 1932. Other Wisconsin Idea scholars at the university generated the plan that became the New Deal's Social Security Act of 1935, with Wisconsin expert Arthur J. Altmeyer playing

19800-451: The world. Recent major outbreaks are the 2010s Haiti cholera outbreak and the 2016–2022 Yemen cholera outbreak . In October 2016, an outbreak of cholera began in war-ravaged Yemen . WHO called it "the worst cholera outbreak in the world". In 2019, 93% of the reported 923,037 cholera cases were from Yemen (with 1911 deaths reported). Between September 2019 and September 2020, a global total of over 450,000 cases and over 900 deaths

19950-523: Was Jonathan Bourne Jr. (senator 1907–1913 and national leader of progressive causes 1911–1912). California built the most successful grass roots progressive movement in the country by mobilizing independent organizations and largely ignoring the conservative state parties. The system continues strong into the 21st century. Following the Oregon model, John Randolph Haynes organized the Direct Legislation League of California in 1902 to launch

20100-503: Was a leader of the Progressive movement, and he championed his " Square Deal " domestic policies, promising the average citizen fairness, breaking of trusts, regulation of railroads, and pure food and drugs. He made conservation a top priority and established many new national parks , forests , and monuments intended to preserve the nation's natural resources. In foreign policy, he focused on Central America where he began construction of

20250-565: Was a main target of Northern philanthropy designed to fight poverty and disease, and help the black community. Booker T. Washington of the National Negro Business League mobilized small black-owned business and secured access to Northern philanthropy. Across the South the General Education Board (funded by the Rockefeller family ) provided large-scale subsidies for black schools, which otherwise continued to be underfunded. The South

20400-540: Was a member of the Republican Party for most of his life, though he also joined the Progressive Party for a brief period. Pinchot is known for reforming the management and development of forests in the United States and for advocating the conservation of the nation's reserves by planned use and renewal. He called it "the art of producing from the forest whatever it can yield for the service of man." Pinchot coined

20550-532: Was a notable figure in the history of social work and women's suffrage in the United States and an advocate of world peace . She co-founded Chicago's Hull House , one of America's most famous settlement houses. In 1920, she was a co-founder for the American Civil Liberties Union (ACLU). In 1931, she became the first American woman to be awarded the Nobel Peace Prize , and is recognized as

20700-458: Was an American writer who wrote nearly 100 books and other works in several genres. Sinclair's work was well known and popular in the first half of the 20th century, and he won the Pulitzer Prize for Fiction in 1943. In 1906, Sinclair acquired particular fame for his classic muck-raking novel The Jungle , which exposed labor and sanitary conditions in the U.S. meatpacking industry , causing

20850-591: Was another investigative journalist and one of the leading muckrakers . He launched a series of articles in McClure's , called Tweed Days in St. Louis , that would later be published together in a book titled The Shame of the Cities . He is remembered for investigating corruption in municipal government in American cities and leftist values. Jane Addams was an American settlement activist, reformer, social worker, sociologist , public administrator and author. She

21000-407: Was bringing to bear scientific, medical, and engineering solutions to reform government and education and foster improvements in various fields including medicine, finance, insurance, industry, railroads, and churches. They aimed to professionalize the social sciences, especially history, economics, and political science and improve efficiency with scientific management or Taylorism. Initially,

21150-528: Was created. Ida Tarbell , a writer and lecturer, was one of the leading muckrakers and pioneered investigative journalism . Tarbell is best known for her 1904 book, The History of the Standard Oil Company . The book was published as a series of articles in McClure's Magazine from 1902 to 1904. The work helped turn elite public opinion against the Standard Oil monopoly. Lincoln Steffens

21300-474: Was moving to the left, advocating some social welfare programs, and criticizing various business practices such as trusts. The leadership of the GOP in Congress moved to the right, as did his protégé President William Howard Taft. Roosevelt broke bitterly with Taft in 1910, and also with Wisconsin's progressive leader Robert M. La Follette . Taft defeated Roosevelt for the 1912 Republican nomination and Roosevelt set up an entirely new Progressive Party. It called for

21450-573: Was one of the few states where former Populists like U'Ren became progressive leaders. U'Ren had been inspired by reading the influential 1893 book Direct Legislation Through the Initiative and Referendum , and the group's founding followed in the wake of the 1896 founding of the National Direct Legislation League, which itself had its roots in the Direct Legislation League of New Jersey and its short-lived predecessor,

21600-594: Was overshadowed by Theodore Roosevelt. La Follette's refusal to support Roosevelt, and especially his suicidal ranting speech before media leaders in February 1912, alienated many progressives. La Follette forfeited his stature as a national leader of progressive Republicans, while remaining a power in Wisconsin. La Follette supported some of President Wilson's policies, but he broke with the president over foreign policy, thereby gaining support from Wisconsin's large German and Scandinavian elements. During World War I, La Follette

21750-532: Was promoted to advance democracy and bring the presumed moral influence of women into politics. For many progressives, prohibition of alcoholic beverages was key to eliminating corruption in politics as well as improving social conditions. Another target were monopolies , which progressives worked to regulate through trustbusting and antitrust laws with the goal of promoting fair competition. Progressives also advocated new government agencies focused on regulation of industry. An additional goal of progressives

21900-408: Was pushed aside by the rise of progressivism. Robert M. La Follette and his family were the dominant forces of progressivism in Wisconsin from the late 1890s to the early 1940s. He tried for a national leadership role in 1912 but blundered badly in a highly embarrassing speech to leading journalists. Starting as a loyal organizational Republican, he broke with the bosses in the late 1890s, built up

22050-629: Was reported; however, the accuracy of these numbers suffer from over-reporting from countries that report suspected cases (and not laboratory confirmed cases), as well as under-reporting from countries that do not report official cases (such as Bangladesh, India and Philippines). Although much is known about the mechanisms behind the spread of cholera, researchers still do not have a full understanding of what makes cholera outbreaks happen in some places and not others. Lack of treatment of human feces and lack of treatment of drinking water greatly facilitate its spread. Bodies of water have been found to serve as

22200-483: Was targeted in the 1920s and 1930s by the Julius Rosenwald Fund , which contributed matching funds to local communities for the construction of thousands of schools for African Americans in rural areas throughout the South. Black parents donated land and labor to build improved schools for their children. North Carolina took a leadership role in modernizing the south, notably in expansion of public education and

22350-440: Was the first recorded incidence of epidemiological tracking. The primary symptoms of cholera are profuse diarrhea and vomiting of clear fluid. These symptoms usually start suddenly, half a day to five days after ingestion of the bacteria. The diarrhea is frequently described as "rice water" in nature and may have a fishy odor. An untreated person with cholera may produce 10 to 20 litres (3 to 5 US gal) of diarrhea

22500-479: Was the most outspoken opponent of the administration's domestic and international policies. With the major parties each nominating conservative candidates in the 1924 presidential election , left-wing groups coalesced behind La Follette's third-party candidacy. With the support of the Socialist Party , farmer's groups, labor unions, and others, La Follette was strong in Wisconsin, and to a much lesser extent in

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