68-595: The British Pharmacopoeia ( BP ) is the national pharmacopoeia of the United Kingdom . It is an annually published collection of quality standards for medicinal substances in the UK, which is used by individuals and organisations involved in pharmaceutical research , development , manufacture and testing . Pharmacopoeial standards are publicly available and legally enforceable standards of quality for medicinal products and their constituents. The British Pharmacopoeia
136-457: A commercial standard of purity as distinct from a medicinal one is needed, since the preparations used in medicine should be of the highest possible degree of purity obtainable, and this standard would be too high and too expensive for ordinary purposes. The use of trade synonyms in the Pharmacopoeia, such as saltpetre for purified potassium nitrate , and milk of sulphur for precipitated sulphur,
204-513: A common monograph that provides a common set of tests and specifications for a specific material. This is a slow process. The World Health Organization has produced the International Pharmacopoeia (Ph.Int.), which does not replace a national pharmacopoeia but rather provides a model or template for one and also can be invoked by legislation within a country to serve as that country's regulation. Though formerly printed there has been
272-513: A consequence of Directive 2001/83/EC , as amended, the British Approved Names, since 2002, may be assumed to be the recommended International Non-proprietary Name (rINN), except where otherwise stated. A World Health Organization (WHO) INN identifies a pharmaceutical substance or active pharmaceutical ingredient by a unique name that is globally recognised, and in which no party can claim any proprietary rights. A non-proprietary name
340-453: A government or a medical or pharmaceutical society. Descriptions of preparations are called monographs . In a broader sense it is a reference work for pharmaceutical drug specifications . The term derives from Ancient Greek : φαρμακοποιία , romanized : pharmakopoiia "making of (healing) medicine, drug-making", a compound of "medicine, drug, poison" ( Ancient Greek : φάρμακον , romanized : pharmakon ), with
408-536: A large number of simples were used in consequence of the same substance being supposed to possess different qualities according to the source from which it was derived. Thus crabs' eyes (i.e., gastroliths ), pearls, oyster shells, and coral were supposed to have different properties. Among other ingredients entering into some of these formulae were the excrements of human beings, dogs, mice, geese, and other animals, calculi , human skull, and moss growing on it, blind puppies, earthworms , etc. Although other editions of
476-540: A legal standard for the drugs and preparations contained in it. The Pharmacopoeia is defined in the preface as only "intended to afford to the members of the medical profession and those engaged in the preparation of medicines throughout the British Empire one uniform standard and guide whereby the nature and composition of, substances to be used in medicine may be ascertained and determined". It cannot be an encyclopaedia of substances used in medicine, and can be used only as
544-520: A prescription only antibiotic without a prescription is not an offence. For description of the legal classification of medicines in the UK see the Royal Pharmaceutical Society web site, and the publication Medicines Ethics and Practice . The act was introduced following problems with the off-label use of thalidomide . The act established the forerunner to the actual Commission on Human Medicines . This legislation in
612-503: A prescription; and general sales list (GSL) medicines which may be bought from any shop without a prescription. The act controls supply of the drugs it covers, but does not define any offence of simple possession. Possession of a prescription only drug without a prescription is only an offence if the drug is also controlled under the Misuse of Drugs Act 1971 and possession is thus specified as an offence. Therefore, for example, possession of
680-736: A result, the Medical Act of 1858 ordained that the General Medical Council should publish a book containing a list of medicines and compounds, to be called the British Pharmacopoeia , which would be a substitute throughout Great Britain and Ireland for the separate pharmacopoeias. Hitherto these had been published in Latin. The first British Pharmacopoeia was published in the English language in 1864, but gave such general dissatisfaction both to
748-571: A standard for the substances and preparations contained in it, and for no others. It has been held in the Divisional Courts (Dickins v. Randerson) that the Pharmacopoeia is a standard for official preparations asked for under their pharmacopoeial name. But there are many substances in the Pharmacopoeia which are not only employed in medicine, but have other uses, such as sulphur , gum benzoin , tragacanth , gum arabic , ammonium carbonate , beeswax , oil of turpentine , linseed oil , and for these
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#1732855876758816-643: A transition to a situation where pharmaceutical information is available as printed volumes and on the internet . The rapid increase in knowledge renders necessary frequent new editions, to furnish definite formulae for preparations that have already come into extensive use in medical practice, so as to ensure uniformity of strength, and to give the characters and tests by which their purity and potency may be determined. However each new edition requires several years to carry out numerous experiments for devising suitable formulae, so that current pharmacopoeia are never quite up to date. This difficulty has hitherto been met by
884-620: Is also known as a generic name . There are equivalent pharmacopoeia in many other countries, such as U.S. (the United States Pharmacopoeia ), Japan ( Japanese Pharmacopoeia ), and China ( Pharmacopoeia of the People's Republic of China ). The World Health Organization maintains The International Pharmacopoeia . The British National Formulary (BNF) and its related publications contain information on prescribing, indications, side effects and costs of all medication available on
952-569: Is an applicable USP-NF quality monograph, drugs and drug ingredients must conform to the compendial requirements (such as for strength, quality or purity) or be deemed adulterated or misbranded under the Federal food and drug laws. The Soviet Union had a nominally supranational pharmacopoeia, the State Pharmacopoeia of the Union of Soviet Socialist Republics (USSRP), although the de facto nature of
1020-542: Is an important statutory component in the control of medicines, which complements and assists the licensing and inspection processes of the UK's Medicines and Healthcare products Regulatory Agency (MHRA). Together with the British National Formulary (BNF), the British Pharmacopoeia defines the UK's pharmaceutical standards. Pharmacopoeial standards are compliance requirements; that is, they provide
1088-417: Is common. Medicines Act 1968 The Medicines Act 1968 (c. 67) is an act of Parliament of the United Kingdom . Its official long title is "An Act to make new provision with respect to medicinal products and related matters, and for purposes connected therewith." It governs the control of medicines for human use and for veterinary use, which includes the manufacture and supply of medicines, and
1156-610: Is no standard of purity that can be used under the Adulteration of Food and Drugs Act, and for these, as well as for the commercial quality of those drugs and essential oils which are also in the Pharmacopoeia, a legal standard of commercial purity is much needed. This subject formed the basis of discussion at several meetings of the Pharmaceutical Society, and the results have been embodied in a work called Suggested Standards for Foods and Drugs by C. G. Moor, which indicates
1224-411: Is partly answerable for this difficulty, and has proved to be a mistake, since it affords ground for legal prosecution if a chemist sells a drug of ordinary commercial purity for trade purposes, instead of the purified preparation which is official in the Pharmacopoeia for medicinal use. This would not be the case if the trade synonym were omitted. For many drugs and chemicals not in the Pharmacopoeia there
1292-642: Is the earliest known Chinese pharmacopoeia. The text describes 365 medicines derived from plants, animals, and minerals; according to legend it was written by the Chinese god Shennong . Pharmacopeial synopsis were recorded in the Timbuktu manuscripts of Mali . The earliest extant Chinese pharmacopoeia, the Shennong Ben Cao Jing was compiled between 200-250 AD. It contains descriptions of 365 medications. The earliest known officially sponsored pharmacopoeia
1360-463: The Antidotarium of Nicolaus de Salerno , containing Galenic formulations arranged alphabetically. Of this last work, there were two editions in use — Nicolaus magnus and Nicolaus parvus: in the latter, several of the compounds described in the large edition were omitted and the formulae given on a smaller scale. Also Vesalius claimed he had written some " dispensariums " and " manuals " on
1428-788: The Antidotarium Florentinum , was published under the authority of the college of medicine of Florence in the 16th century. In 1511, the Concordie Apothecariorum Barchinone was published by the Society of Apothecaries of Barcelona and kept in the School of Pharmacy of the University of Barcelona . The term Pharmacopoeia first appears as a distinct title in a work published at Basel , Switzerland, in 1561 by A. Foes, but does not appear to have come into general use until
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#17328558767581496-613: The BP , and provided standards for these. The Medicines Act 1968 established the legal status of the British Pharmacopoeia Commission , and of the British Pharmacopoeia , as the UK standard for medicinal products under section 4 of the Act. The British Pharmacopoeia Commission continues the work of the earlier Commissions appointed by the GMC, and is responsible for preparing new editions of
1564-597: The British Empire . As regards the purely pharmaceutical part of the work a committee of reference in pharmacy, nominated by the pharmaceutical societies of Great Britain and Ireland (as they were then), was appointed to report to the Pharmacopoeia Committee of the Medical Council. Some difficulty has arisen since the passing of the Adulteration of Food and Drugs Act concerning the use of the Pharmacopoeia as
1632-537: The British Pharmacopoeia and the British Pharmacopoeia (Veterinary) , and for keeping them up to date. Under Section 100 of the Medicines Act, the Commission is also responsible for selecting and devising British Approved Names . Since its first publication in 1864, the distribution of the British Pharmacopoeia has grown throughout the world and it is now used in over 100 countries. Australia and Canada are two of
1700-471: The British Pharmacopoeia is available from The Stationery Office Bookshop . Detailed information and guidance on various aspects of current pharmacopoeial policy and practice is provided in supplementary chapters of the British Pharmacopoeia . This includes explanation of the basis of pharmacopoeial specifications, and information on the development of monographs including guidance to manufacturers. British Approved Names (BANs) are devised or selected by
1768-575: The International Society for the History of Medicine , with agreement of John M. Riddle , one of the foremost experts on Materia Medica - Dioscorides works. Nicolaes Tulp , mayor of Amsterdam and respected surgeon general, gathered all of his doctor and chemist friends together and they wrote the first pharmacopoeia of Amsterdam named Pharmacopoea Amstelredamensis in 1636. This was a combined effort to improve public health after an outbreak of
1836-678: The Medicines Act 1968 , and notified in draft to the European Commission (EC) in accordance with Directive 98/34/EEC . The monographs of the European Pharmacopoeia (as amended by Supplements published by the Council of Europe ) are reproduced either in the British Pharmacopoeia , or in the associated edition of the British Pharmacopoeia (Veterinary) . In the pharmacopoeia, certain drugs and preparations are included regardless of
1904-469: The National Health Service . [REDACTED] The dictionary definition of Pharmacopoeia at Wiktionary Pharmacopoeia A pharmacopoeia , pharmacopeia , or pharmacopoea (from the obsolete typography pharmacopœia , meaning "drug-making"), in its modern technical sense, is a book containing directions for the identification of compound medicines , and published by the authority of
1972-553: The Pharmaceutical Society . A commission was first appointed by the General Medical Council (GMC), when the body was made statutorily responsible under the Medical Act 1858 for producing a British pharmacopoeia on a national basis. In 1907, the British Pharmacopoeia was supplemented by the British Pharmaceutical Codex , which gave information on drugs and other pharmaceutical substances not included in
2040-501: The bubonic plague , and also to limit the number of quack apothecary shops in Amsterdam. Until 1617, such drugs and medicines as were in common use were sold in England by the apothecaries and grocers. In that year the apothecaries obtained a separate charter, and it was enacted that no grocer should keep an apothecary's shop. The preparation of physicians' prescriptions was thus confined to
2108-525: The British Pharmacopoeia Commission (BPC), and its Expert Advisory Groups (EAG) and Advisory Panels. The development of pharmacopoeial standards receives input from relevant industries, hospitals, academia, professional bodies and governmental sources, both within and outside the UK. The British Pharmacopoeia Laboratory provides analytical and technical support to the British Pharmacopoeia . Its major functions are: The current edition of
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2176-516: The British Pharmacopoeia Commission (BPC), and published by the Health Ministers, on the recommendation of the Commission on Human Medicines, to provide a list of names of substances or articles referred to in Section 100 of the Medicines Act 1968 . BANs are short, distinctive names for substances, where the systematic chemical or other scientific names are too complex for convenient general use. As
2244-505: The British Pharmacopoeia in 1898. A committee of the Royal Pharmaceutical Society of Great Britain was appointed at the request of the General Medical Council to advise on pharmaceutical matters. A census of prescriptions was taken to ascertain the relative frequency with which different preparations and drugs were used in prescriptions, and suggestions and criticisms were sought from various medical and pharmaceutical bodies across
2312-499: The EU. In the U.S., the USP-NF (United States Pharmacopeia – National Formulary) has been issued by a private non-profit organization since 1820 under the authority of a Convention that meets periodically that is largely constituted by physicians, pharmacists, and other public health professionals, setting standards published in the compendia through various Expert Committees. In the U.S. when there
2380-490: The London Pharmacopoeia were issued in 1621, 1632, 1639, and 1677, it was not until the edition of 1721, published under the auspices of Sir Hans Sloane , that any important alterations were made. In this issue many of the remedies previously in use were omitted, although a good number were still retained, such as dogs' excrement, earthworms, and moss from the human skull; the botanical names of herbal remedies were for
2448-693: The London area, and to destroy defective stock. The first list of approved drugs , with information on how they should be prepared, was the London Pharmacopoeia , published in 1618. The first edition of what is now known as the British Pharmacopoeia was published in 1864, and was one of the first attempts to harmonise pharmaceutical standards, through the merger of the London , Edinburgh and Dublin Pharmacopoeias . The Neo-Latin name that had some currency at
2516-409: The Pharmacopoeia is shown by the fact that they are even more largely used than the Pharmacopoeia itself, the first issued in 18 editions and the second in 13 editions at comparatively short intervals. In the UK, the task of elaborating a new Pharmacopoeia is entrusted to a body of a purely medical character, and legally the pharmacist does not, contrary to the practice in other countries, have a voice in
2584-402: The anonymous " Dispensarium or Enquiridion " in 1543, at Lyon , France, with Jean Frellon as editor. This work contains 224 original recipes by De Villeneuve and others by Lespleigney and Chappuis. As usual when it comes to pharmacopoeias, this work was complementary to a previous Materia Medica that De Villeneuve published that same year. This finding was communicated by the same scholar in
2652-576: The apothecaries, upon whom pressure was brought to bear to make them dispense accurately, by the issue of a pharmacopoeia in May 1618 by the College of Physicians , and by the power which the wardens of the apothecaries received in common with the censors of the College of Physicians of examining the shops of apothecaries within 7 m. of London and destroying all the compounds which they found unfaithfully prepared. This,
2720-462: The average degree of purity of many drugs and chemicals used in the arts, as well as the highest degree of purity obtainable in commerce of those used in medicine. An important step has also been taken in this direction by the publication under the authority of the Council of the Pharmaceutical Society of Great Britain of the British Pharmaceutical Codex (BPC), in which the characters of and tests for
2788-835: The banner of the International Council on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use (ICH), a tri-regional organisation that represents the drug regulatory authorities of the European Union , Japan , and the United States . Representatives from the Pharmacopoeias of these three regions have met twice yearly since 1990 in the Pharmacopoeial Discussion Group to try to work towards "compendial harmonisation". Specific monographs are proposed, and if accepted, proceed through stages of review and consultation leading to adoption of
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2856-529: The beginning of the 17th century. Before 1542, the works principally used by apothecaries were the treatises on simples (basic medicinal ingredients) by Avicenna and Serapion ; the De synonymis and Quid pro quo of Simon Januensis ; the Liber servitoris of Bulchasim Ben Aberazerim , which described preparations made from plants, animals, and minerals, and was the type of the chemical portion of modern pharmacopoeias; and
2924-401: The commercial grade of purity of those in the Pharmacopoeia which are used for non-medical purposes. Another legal difficulty connected with modern pharmacopoeias is the inclusion in some of them of synthetic chemical remedies, the processes for preparing which have been patented, whilst the substances are sold under trade-mark names. The scientific chemical name is often long and unwieldy, and
2992-411: The construction of a pharmacopoeia is now fully recognized in other countries, in most of which pharmaceutical chemists are represented on the committee for the preparation of the legally recognized manuals. There are national and international pharmacopoeias, like the EU and the U.S. pharmacopoeias. The pharmacopeia in the EU is prepared by a governmental organization, and has a specified role in law in
3060-465: The countries that have adopted the BP as their national standard; in other countries, such as South Korea , the BP is recognised as an acceptable reference standard. The current edition of the British Pharmacopoeia comprises six volumes, which contain nearly 3,000 monographs for drug substances, excipients , and formulated preparation, together with supporting general notices, appendices (test methods, reagents etc.), and reference spectra, used in
3128-573: The electronic products use sophisticated search techniques to locate information quickly. For example, pharmacists referring to a monograph can immediately link to other related substances and appendices referenced in the content by using 130,000+ hypertext links within the text. The British Pharmacopoeia is prepared by the Pharmacopoeial Secretariat, working in collaboration with the British Pharmacopoeia Laboratory,
3196-486: The existence of actual or potential patent rights . Where substances are protected by letters patent , their inclusion in the pharmacopoeia neither conveys, nor implies, licence to manufacture. The regulation of medicinal products by officials in the United Kingdom dates back to the reign of King Henry VIII (1491–1547). The Royal College of Physicians of London had the power to inspect apothecaries’ products in
3264-409: The first authorized London Pharmacopoeia, was selected chiefly from the works of Mezue and Nicolaus de Salerno, but it was found to be so full of errors that the whole edition was cancelled, and a fresh edition was published in the following December. At this period the compounds employed in medicine were often heterogeneous mixtures, some of which contained from 20 to 70, or more, ingredients, while
3332-403: The first time added to the official ones; the simple distilled waters were ordered of a uniform strength; sweetened spirits, cordials and ratafias were omitted as well as several compounds no longer used in London, although still in vogue elsewhere. A great improvement was effected in the edition published in 1746, in which only those preparations were retained which had received the approval of
3400-569: The major initial work in the field is considered to be the Edwin Smith Papyrus in Egypt , Pliny 's pharmacopoeia. A number of early pharmacopoeia books were written by Persian and Arab physicians . These included The Canon of Medicine of Avicenna in 1025 AD, and works by Ibn Zuhr (Avenzoar) in the 12th century (and printed in 1491), and Ibn Baytar in the 14th century. The Shen-nung pen ts'ao ching (Divine Husbandman's Materia Medica)
3468-399: The majority of the pharmacopoeia committee; to these was added a list of those drugs only which were supposed to be the most efficacious. An attempt was made to simplify further the older formulae by the rejection of superfluous ingredients. In the edition published in 1788 the tendency to simplify was carried out to a much greater extent, and the extremely compound medicines which had formed
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#17328558767583536-421: The manufacture and supply of (medicated) animal feeding stuffs . The act defines three categories of medicine: prescription only medicines (POM), which are available only from a pharmacist if prescribed by an appropriate practitioner (including, but not limited to doctors , dentists , optometrists , prescribing pharmacists and nurses ); pharmacy medicines (P), available only from a pharmacist but without
3604-414: The matter. This is notwithstanding the fact that, although the medical practitioner is naturally the best judge of the drug or preparations that will afford the best therapeutic result, they are not as competent as the pharmacist to say how that preparation can be produced in the most effective and satisfactory manner, nor how the purity of drugs can be tested. The change occurred with the fourth edition of
3672-571: The means for an independent judgement as to the overall quality of an article, and apply throughout the shelf-life of a product. Inclusion of a substance in a pharmacopoeia does not indicate that it is either safe or effective for the treatment of any disease. The British Pharmacopoeia is published on behalf of the Health Ministers of the United Kingdom ; on the recommendation of the Commission on Human Medicines , in accordance with section 99(6) of
3740-498: The medical profession and to chemists and druggists that the General Medical Council brought out a new and amended edition in 1867. This dissatisfaction was probably owing partly to the fact that the majority of the compilers of the work were not engaged in the practice of pharmacy, and therefore not competent to decide upon the kind of preparations required for the method of their manufacture. The necessity for this element in
3808-713: The nationality of republics within that state differed from the de jure nature. The European Union has a supranational pharmacopoeia, the European Pharmacopoeia ; it has not replaced the national pharmacopoeias of EU member states but rather helps to harmonize them. Attempts have been made by international pharmaceutical and medical conferences to settle a basis on which a globally international pharmacopoeia could be prepared, but regulatory complexity and regional variation in conditions of pharmacy are hurdles to fully harmonizing across all countries (that is, defining thousands of details that can all be known to work successfully in all places). Nonetheless, some progress has been made under
3876-568: The patentee for infringement of patent rights. Hence the only solution is for the physician to use the chemical name (which cannot be patented) as given in the Pharmacopoeia, or, for those synthetic remedies not included in the Pharmacopoeia, the scientific and chemical name given in the British Pharmaceutical Codex . In most of the Neo-Latin names, Pharmacopoea is the more common spelling, although for several of them, Pharmacopoeia
3944-408: The physician prefers when writing a prescription to use the shorter name under which it is sold by the patentees . In this case the pharmacist is compelled to use the more expensive patented article, which may lead to complaints from the patient. If the physician were to use the same article under its pharmacopoeial name when the patented article is prescribed, they would become open to prosecution by
4012-400: The practice of medicine , all comprehensively indexed and cross-referenced for easy reference. Items used exclusively in veterinary medicine in the UK are included in the BP (Veterinary) . Volumes I and II Volume III Volume IV Volume V Volume VI: (CD-ROM version) The British Pharmacopoeia is available as a printed volume and electronically in both on-line and CD-ROM versions;
4080-482: The principal remedies of physicians for 2,000 years were discarded, while a few powerful drugs which had been considered too dangerous to be included in the Pharmacopoeia of 1765 were restored to their previous position. In 1809 the French chemical nomenclature was adopted, and in 1815 a corrected impression of the same was issued. Subsequent editions were published in 1824, 1836, and 1851. The first Edinburgh Pharmacopoeia
4148-477: The publication of such non-official formularies as Squire's Companion to the Pharmacopoeia and Martindale: The complete drug reference (formerly Martindale's: the extra pharmacopoeia ), in which all new remedies and their preparations, uses and doses are recorded, and in the former the varying strengths of the same preparations in the different pharmacopoeias are also compared (Squire's was incorporated into Martindale in 1952). The need of such works to supplement
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#17328558767584216-413: The purity of many unofficial drugs and preparations are given as well as the character of many glandular preparations and antitoxins that have come into use in medicine, but have not yet been introduced into the Pharmacopoeia. This work may also possibly serve as a standard under the Adulteration of Food and Drugs Act for the purity and strength of drugs not included in the Pharmacopoeia and as a standard for
4284-462: The time was Pharmacopoeia Britannica (Ph. Br.). In 1844, concern about the dangers of unregulated manufacture and use led William Flockhart – who had provided chloroform to Doctor (later Sir) James Young Simpson for his experiment on anaesthesia – to recommend the creation of a 'Universal Phamacopoeia for Great Britain' in his inaugural speech as president of the Northern British branch of
4352-663: The verb "to make" ( Ancient Greek : ποιεῖν , romanized : poiein ), and the abstract noun suffix -ία -ia . In early modern editions of Latin texts, the Greek diphthong οι ( oi ) is latinized to its Latin equivalent oe which is in turn written with the ligature œ , giving the spelling pharmacopœia ; in modern UK English , œ is written as oe , giving the spelling pharmacopoeia , while in American English oe becomes e , giving us pharmacopeia . Although older writings exist which deal with herbal medicine ,
4420-494: The works of Galenus . Apparently he burnt them. According to recent research communicated at the congresses of the International Society for the History of Medicine by the scholar Francisco Javier González Echeverría, Michel De Villeneuve ( Michael Servetus ) also published a pharmacopoeia. De Villeneuve, fellow student of Vesalius and the best galenist of Paris according to Johann Winter von Andernach , published
4488-600: Was compiled in 659 AD by a team of 23 pharmaceutical scientists led by Su jing during the Tang dynasty (618-907 AD) and was called the Xinxiu bencao (Newly Revised Canon of Material Medical). The work consists of 20 volumes with one dedicated to the table of contents, and 25 volumes of pictures with one volume dedicated to the table of contents. A third part consisting of seven volumes contained illustrated descriptions. The text contains descriptions of 850 medicines with 114 new ones. The work
4556-419: Was published in 1699 and the last in 1841; the first Dublin Pharmacopoeia in 1807 and the last in 1850. The preparations contained in these three pharmacopoeias were not all uniform in strength, a source of much inconvenience and danger to the public, when powerful preparations such as dilute hydrocyanic acid were ordered in the one country and dispensed according to the national pharmacopoeia in another. As
4624-483: Was used throughout China for the next 400 years. A dated work appeared in Nuremberg in 1542; a passing student Valerius Cordus showed a collection of medical prescriptions, which he had selected from the writings of the most eminent medical authorities, to the physicians of the town, who urged him to print it for the benefit of the apothecaries , and obtained the sanction of the senatus for his work. A work known as
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