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35-687: [REDACTED] Look up bora  or Bora in Wiktionary, the free dictionary. Bora may refer to: Geography [ edit ] Bora (Australian) , the site of an initiation ceremony in Australian aboriginal culture, sometimes known as Bora rings Bora, India , a village in Punjab, India Borá , a city in the São Paulo state in Brazil Bora (wind) ,

70-664: A Korean feminine given name (including a list of people with the name) Bora (Albanian name) , an Albanian feminine given name Bora (Turkish name) , a Turkish masculine given (including a list of people with the name) Bora Milutinović former footballer and manager Transportation and vehicles [ edit ] Bora-class corvette , a hoverborne guided missile corvette in the Russian navy Bora One and Bora Two, aerodynamic bicycle wheels manufactured by Italian company Campagnolo Paradelta Bora , an Italian paraglider design Maserati Bora , an Italian sports car named after

105-473: A Marvel Comics character with wind-related powers Bora Horza Gobuchul, the protagonist of the novel Consider Phlebas by Iain M. Banks Television [ edit ] Bora (television series) Bora, a super-powerful robot that fought Pluto in an Astro Boy (1980 TV series) episode; Bora's attack is a powerful cry that releases a katabatic wind Bora, a character in Dragon Ball Bora,

140-457: A Turkish masculine given (including a list of people with the name) Bora Milutinović former footballer and manager Transportation and vehicles [ edit ] Bora-class corvette , a hoverborne guided missile corvette in the Russian navy Bora One and Bora Two, aerodynamic bicycle wheels manufactured by Italian company Campagnolo Paradelta Bora , an Italian paraglider design Maserati Bora , an Italian sports car named after

175-592: A Witotoan language spoken in Western Amazon forest region (Peru, Brazil, and Colombia) Bora people , the ethnic group that speaks the Bora language Name [ edit ] Bora (surname) ; also a former military/professional title in Assam Bora (Korean name) , a Korean feminine given name (including a list of people with the name) Bora (Albanian name) , an Albanian feminine given name Bora (Turkish name) ,

210-432: A group of rebel colonists found in the 2000 game Tachyon: The Fringe People [ edit ] Culture [ edit ] Bora language , a Witotoan language spoken in Western Amazon forest region (Peru, Brazil, and Colombia) Bora people , the ethnic group that speaks the Bora language Name [ edit ] Bora (surname) ; also a former military/professional title in Assam Bora (Korean name) ,

245-409: A motor protein involved in the formation of the bipolar mitotic spindle. γ-tubulins , the base structure from which centrosomal microtubules polymerize , are also recruited by Aurora A. Without Aurora A the centrosome does not accumulate the quantity of γ-tubulin that normal centrosomes recruit prior to entering anaphase . Though the cell cycle continues even in the absence of sufficient γ-tubulin,

280-801: A north to north-eastern katabatic wind in areas near the Adriatic Sea. Bora River, a name for the Lotru River in Romania Bora River, a semi-fictional river in The African Queen (novel) , also named the Ulanga-Bora River, know often known as the Ulanga River . Art, entertainment, and media [ edit ] Fictional entities [ edit ] Bora (comics) , a Marvel Comics character with wind-related powers Bora Horza Gobuchul,

315-480: A village in Punjab, India Borá , a city in the São Paulo state in Brazil Bora (wind) , a north to north-eastern katabatic wind in areas near the Adriatic Sea. Bora River, a name for the Lotru River in Romania Bora River, a semi-fictional river in The African Queen (novel) , also named the Ulanga-Bora River, know often known as the Ulanga River . Art, entertainment, and media [ edit ] Fictional entities [ edit ] Bora (comics) ,

350-499: Is an enzyme that in humans is encoded by the AURKA gene . Aurora A is a member of a family of mitotic serine/threonine kinases . It is implicated with important processes during mitosis and meiosis whose proper function is integral for healthy cell proliferation . Aurora A is activated by one or more phosphorylations and its activity peaks during the G2 phase to M phase transition in

385-412: Is associated with centrosome maturation and separation and thereby regulates spindle assembly and stability. The Aurora kinase B is a chromosome passenger protein and regulates chromosome segregation and cytokinesis . Although there is evidence to suggest that Aurora C might be a chromosomal passenger protein, the cellular function of it is less clear. Aurora A localizes next to the centrosome late in

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420-496: Is different from Wikidata All article disambiguation pages All disambiguation pages Language and nationality disambiguation pages bora [REDACTED] Look up bora  or Bora in Wiktionary, the free dictionary. Bora may refer to: Geography [ edit ] Bora (Australian) , the site of an initiation ceremony in Australian aboriginal culture, sometimes known as Bora rings Bora, India ,

455-518: Is different from Wikidata All article disambiguation pages All disambiguation pages Language and nationality disambiguation pages Aurora A kinase 6790 20878 ENSG00000087586 ENSMUSG00000027496 O14965 P97477 NM_198437 NM_001323303 NM_001323304 NM_001323305 NM_011497 NM_001291185 NP_940836 NP_940837 NP_940838 NP_940839 NP_001278114 NP_035627 Aurora kinase A also known as serine/threonine-protein kinase 6

490-410: Is unknown, it is well documented that it relocalizes to the mid-body immediately before the completion of mitosis. Intriguingly, abolishment of Aurora A through RNAi interference results in different mutant phenotypes in different organisms and cell types. For example, deletion of Aurora A in C. elegans results in an initial separation of the cell's centrosomes followed by an immediate collapse of

525-483: The G1 phase and early in the S phase . As the cell cycle progresses, concentrations of Aurora A increase and the kinase associates with the mitotic poles and the adjacent spindle microtubules. Aurora A remains associated with the spindles through telophase . Right before mitotic exit, Aurora A relocalizes to the mid-zone of the spindle. During mitosis, a mitotic spindle is assembled by using microtubules to tether together

560-540: The Bora wind Volkswagen Bora /Jetta, a German small sedan, named after the Bora wind Other uses [ edit ] Bora (wind) , a katabatic wind in the Adriatic Sea and the Black Sea regions of southeastern Europe and Turkey Bora (missile) , a tactical ballistic missile of Turkey Bora, an Aurora A kinase activator in the cell cycle BORA, acronym for the New Zealand Bill of Rights Act 1990 Bora,

595-430: The Bora wind Volkswagen Bora /Jetta, a German small sedan, named after the Bora wind Other uses [ edit ] Bora (wind) , a katabatic wind in the Adriatic Sea and the Black Sea regions of southeastern Europe and Turkey Bora (missile) , a tactical ballistic missile of Turkey Bora, an Aurora A kinase activator in the cell cycle BORA, acronym for the New Zealand Bill of Rights Act 1990 Bora,

630-477: The Guyanese name for Vigna unguiculata subsp. sesquipedalis , a legume that grows in tropical and subtropical climates Bora–Hansgrohe , a cycling team sponsored by a German manufacturer of cooktops. See also [ edit ] Yoon Bo-ra , a South Korean idol singer Bohra (disambiguation) Bora Bora (disambiguation) Bori (disambiguation) Borat , a fictional character Topics referred to by

665-426: The Guyanese name for Vigna unguiculata subsp. sesquipedalis , a legume that grows in tropical and subtropical climates Bora–Hansgrohe , a cycling team sponsored by a German manufacturer of cooktops. See also [ edit ] Yoon Bo-ra , a South Korean idol singer Bohra (disambiguation) Bora Bora (disambiguation) Bori (disambiguation) Borat , a fictional character Topics referred to by

700-463: The asters. In Xenopus , deletion disallows the mitotic spindle from ever even forming. And in Drosophila , flies without Aurora A will effectively form spindles and separate but the aster microtubules will be dwarfed. These observations suggests that while Aurora-A has orthologues in many different organisms, it may play a similar but slightly different role in each. Aurora A phosphorylation directs

735-416: The cell begins mitosis, duplicates its DNA, but is then not able to divide into two separate cells it becomes an aneuploid - containing more chromosomes than normal. Aneuploidy is a trait of many cancerous tumors. Ordinarily, Aurora A expression levels are kept in check by the tumor suppressor protein p53 . Mutations of the chromosome region that contains Aurora A, 20q13, are generally considered to have

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770-470: The cell cycle. The aurora kinases were first identified in 1990 during a cDNA screen of Xenopus eggs. The kinase discovered, Eg2, is now referred to as Aurora A. However, Aurora A's meiotic and mitotic significance was not recognized until 1998. The human genome contains three members of the aurora kinase family: Aurora kinase A, Aurora kinase B and Aurora C kinase . The Xenopus , Drosophila , and Caenorhabditis elegans genomes, on

805-449: The centrosome never fully matures; it organizes fewer aster microtubules than normal. Furthermore, Aurora A is necessary for the proper separation of the centrosomes after the mitotic spindle has been formed. Without Aurora A, the mitotic spindle, depending on the organism, will either never separate or will begin to separate only to collapse back onto itself. In the case of the former, it has been suggested that Aurora A cooperates with

840-407: The completion of cytokinesis - the process by which the cytoplasm of the parent cell is split into two daughter cells. During cytokinesis the mother centriole returns to the mid-body of the mitotic cell at the end of mitosis and causes the central microtubules to release from the mid-body. The release allows mitosis to run to completion. Though the exact mechanism by which Aurora A aids cytokinesis

875-570: The cytoplasmic polyadenylation translation of mRNA's, like the MAP kinase kinase kinase protein MOS, that are vital to the completion of meiosis in Xenopus Oocytes . Prior to the first meiotic metaphase , Aurora A induces the synthesis of MOS. The MOS protein accumulates until it exceeds a threshold and then transduces the phosphorylation cascade in the map kinase pathway. This signal subsequently activates

910-509: The fluctuations, or phases, of Aurora A activation are dependent on a positive-feedback mechanism with a p13SUC1-associated protein kinase Aurora A is not only implicated with the translation of MOS during meiosis but also in the polyadenylation and subsequent translation of neural mRNAs whose protein products are associated with synaptic plasticity. Aurora A dysregulation has been associated with high occurrence of cancer. For example, one study showed over-expression of Aurora A in 94 percent of

945-480: The invasive tissue growth in breast cancer, while surrounding, healthy tissues had normal levels of Aurora A expression. Aurora A has also been shown to be involved in the Epithelial–mesenchymal transition and Neuroendocrine Transdifferentiation of Prostate Cancer cells in aggressive disease. Dysregulation of Aurora A may lead to cancer because Aurora A is required for the completion of cytokinesis . If

980-447: The kinase Nek2 in Xenopu s to dissolve the structure tethering the cell's centrosomes together. Therefore, without proper expression of Aurora A, the cell's centrosomes are never able to separate. Aurora A also assures proper organization and alignment of the chromosomes during prometaphase . It is directly involved in the interaction of the kinetochore, the part of the chromosome at which

1015-453: The kinase RSK which in turn binds to the protein Myt1. Myt1, in complex with RSK, is now unable to inhibit cdc2 . As a consequence, cdc2 permits entry into meiosis. A similar Aurora A dependent process regulates the transition from meiosis I-meiosis II. Furthermore, Aurora A has been observed to have a biphasic pattern of activation during progression through meiosis. It has been suggested that

1050-411: The mitotic spindle attaches and pulls, and the mitotic spindle's extended microtubules. It is speculated that Aurora B cooperates with Aurora A to complete this task. In the absence of Aurora A mad2, a protein that normally dissipates once a proper kinetochore-microtubule connection is made, remains present even into metaphase. Finally, Aurora A helps orchestrate an exit from mitosis by contributing to

1085-468: The mother centrosome to its daughter. The resulting mitotic spindle is then used to propel apart the sister chromosomes into what will become the two new daughter cells. Aurora A is critical for proper formation of mitotic spindle. It is required for the recruitment of several different proteins important to the spindle formation. Among these target proteins are TACC, a microtubule -associated protein that stabilizes centrosomal microtubules and Kinesin 5,

Bora - Misplaced Pages Continue

1120-456: The other hand, contain orthologues only to Aurora A and Aurora B. In all studied species, the three Aurora mitotic kinases localize to the centrosome during different phases of mitosis. The family members have highly conserved C-terminal catalytic domains. Their N-terminal domains, however, exhibit a large degree of variance in the size and sequence. Aurora A and Aurora B kinases play important roles in mitosis . The Aurora kinase A

1155-495: The protagonist of the novel Consider Phlebas by Iain M. Banks Television [ edit ] Bora (television series) Bora, a super-powerful robot that fought Pluto in an Astro Boy (1980 TV series) episode; Bora's attack is a powerful cry that releases a katabatic wind Bora, a character in Dragon Ball Bora, a group of rebel colonists found in the 2000 game Tachyon: The Fringe People [ edit ] Culture [ edit ] Bora language ,

1190-444: The same term [REDACTED] This disambiguation page lists articles associated with the title Bora . If an internal link led you here, you may wish to change the link to point directly to the intended article. Retrieved from " https://en.wikipedia.org/w/index.php?title=Bora&oldid=1248038057 " Categories : Disambiguation pages Place name disambiguation pages Hidden categories: Short description

1225-444: The same term [REDACTED] This disambiguation page lists articles associated with the title Bora . If an internal link led you here, you may wish to change the link to point directly to the intended article. Retrieved from " https://en.wikipedia.org/w/index.php?title=Bora&oldid=1248038057 " Categories : Disambiguation pages Place name disambiguation pages Hidden categories: Short description

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