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106-749: In archaeogenetics , the term Ancient Northern East Asian (ANEA) , also known as Northern East Asian (NEA) , is used to summarize the related ancestral components that represent the Ancient Northern East Asian peoples, extending from the Baikal region to the Yellow River and the Qinling-Huaihe Line in present-day central China. They are inferred to have diverged from Ancient Southern East Asians (ASEA) around 20,000 to 26,000 BCE. The ANEA can be differentiated into broadly three sub-groups, namely

212-514: A blood group ) is a classification of blood , based on the presence and absence of antibodies and inherited antigenic substances on the surface of red blood cells (RBCs). These antigens may be proteins , carbohydrates , glycoproteins , or glycolipids , depending on the blood group system. Some of these antigens are also present on the surface of other types of cells of various tissues . Several of these red blood cell surface antigens can stem from one allele (or an alternative version of

318-455: A fetus with a blood type which is different from her own. Typically, this is an issue if a Rh- mother has a child with a Rh+ father, and the fetus ends up being Rh+ like the father. In those cases, the mother can make IgG blood group antibodies. This can happen if some of the fetus' blood cells pass into the mother's blood circulation (e.g. a small fetomaternal hemorrhage at the time of childbirth or obstetric intervention), or sometimes after

424-694: A microscope . If agglutination occurs, that particular donor's blood cannot be transfused to that particular recipient. In a blood bank it is vital that all blood specimens are correctly identified, so labelling has been standardized using a barcode system known as ISBT 128 . The blood group may be included on identification tags or on tattoos worn by military personnel, in case they should need an emergency blood transfusion. Frontline German Waffen-SS had blood group tattoos during World War II . Rare blood types can cause supply problems for blood banks and hospitals. For example, Duffy -negative blood occurs much more frequently in people of African origin, and

530-431: A basic laboratory setup and chemicals. It is also independent of sample size, as the process can be scaled to accommodate larger or smaller quantities. Another benefit is that the process can be executed at room temperature. However, this method does contain some drawbacks. Mainly, silica-based DNA extraction can only be applied to bone and teeth samples; they cannot be used on soft tissue . While they work well with

636-425: A blood bank would be suitable for a recipient who may be D positive or D negative, as long as blood plasma and the recipient are ABO compatible. In transfusions of packed red blood cells, individuals with type O Rh D negative blood are often called universal donors. Those with type AB Rh D positive blood are called universal recipients. However, these terms are only generally true with respect to possible reactions of

742-431: A blood sample to a solution containing antibodies corresponding to each antigen. The presence of an antigen on the surface of the blood cells is indicated by agglutination . In addition to the current practice of serologic testing of blood types, the progress in molecular diagnostics allows the increasing use of blood group genotyping. In contrast to serologic tests reporting a direct blood type phenotype, genotyping allows

848-545: A closely related extant species can be used to estimate the divergence time of those two species from their last common ancestor . The phylogeny of some extinct species, such as Australian marsupial wolves and American ground sloths , has been constructed by this method. Mitochondrial DNA in animals and chloroplast DNA in plants are usually used for this purpose because they have hundreds of copies per cell and thus are more easily accessible in ancient fossils. Another method to investigate relationship between two species

954-477: A date of over 300 kya. Examination of mitochondrial DNA (mtDNA), Y-chromosome DNA, and X-chromosome DNA indicate that the earliest population to leave Africa consisted of approximately 1500 males and females. It has been suggested by various studies that populations were geographically “structured” to some degree prior to the expansion out of Africa; this is suggested by the antiquity of shared mtDNA lineages. One study of 121 populations from various places throughout

1060-600: A gene) and collectively form a blood group system. Blood types are inherited and represent contributions from both parents of an individual. As of 31 December 2023, a total of 45 human blood group systems are recognized by the International Society of Blood Transfusion (ISBT). The two most important blood group systems are ABO and Rh ; they determine someone's blood type (A, B, AB, and O, with + or − denoting RhD status) for suitability in blood transfusion . A complete blood type would describe each of

1166-426: A major bleed when stocks of D-negative blood units are very low at the blood bank, D-positive blood might be given to D-negative females above child-bearing age or to Rh-negative males, providing that they did not have anti-D antibodies, to conserve D-negative blood stock in the blood bank. The converse is not true; Rh D-positive patients do not react to D negative blood. This same matching is done for other antigens of

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1272-449: A minor contribution from Ancient Southern East Asians (ASEA) led to the formation of the "Yellow River farmers". Yellow River farmers are associated with the spread of Sino-Tibetan languages . The "Neo-Siberians," or "inland Northeast Asians" (including Yumin hunter-gatherers and Transbaikal_EMN ancestry), are associated with an inland expansion route of Ancient Northern East Asians around 14,000 years ago. They can be distinguished from

1378-441: A person receives bone marrow from someone of a different ABO type (e.g., a type O patient receives a type A bone marrow), the patient's blood type should eventually become the donor's type, as the patient's hematopoietic stem cells (HSCs) are destroyed, either by ablation of the bone marrow or by the donor's T-cells. Once all the patient's original red blood cells have died, they will have been fully replaced by new cells derived from

1484-450: A potential donor is found to have anti-D antibodies or any strong atypical blood group antibody by antibody screening in the blood bank, they would not be accepted as a donor (or in some blood banks the blood would be drawn but the product would need to be appropriately labeled); therefore, donor blood plasma issued by a blood bank can be selected to be free of D antibodies and free of other atypical antibodies, and such donor plasma issued from

1590-444: A result of transfusion. For transfusions of plasma , this situation is reversed. Type O plasma, containing both anti-A and anti-B antibodies, can only be given to O recipients. The antibodies will attack the antigens on any other blood type. Conversely, AB plasma can be given to patients of any ABO blood group, because it does not contain any anti-A or anti-B antibodies. Typically, blood type tests are performed through addition of

1696-559: A sample, even when it is highly fragmented and of low concentration. It involves attaching a generic sequence to every single strand that generic primers can bond to, and thus all of the DNA present is amplified. This is generally more costly and time intensive than PCR but due to the difficulties involved in ancient DNA amplification it is cheaper and more efficient. One method of massive parallel sequencing , developed by Margulies et al., employs bead-based emulsion PCR and pyrosequencing , and

1802-561: A sensitizing event: possibly a fetomaternal transfusion of blood from a fetus in pregnancy or occasionally a blood transfusion with D positive RBCs . Rh disease can develop in these cases. Rh negative blood types are much less common in Asian populations (0.3%) than they are in European populations (15%). The presence or absence of the Rh(D) antigen is signified by the + or − sign, so that, for example,

1908-410: A similar way as medicines. Much of the routine work of a blood bank involves testing blood from both donors and recipients to ensure that every individual recipient is given blood that is compatible and as safe as possible. If a unit of incompatible blood is transfused between a donor and recipient, a severe acute hemolytic reaction with hemolysis (RBC destruction), kidney failure and shock

2014-592: A similarity in 2.18 and 1.62 bases per 10,000 respectively, suggesting Vi-80 sample was from a male individual. Other similar studies include finding of a mutation associated with dwarfism in Arabidopsis in ancient Nubian cotton , and investigation on the bitter taste perception locus in Neanderthals. Modern humans are thought to have evolved in Africa at least 200 kya (thousand years ago), with some evidence suggesting

2120-593: A single migratory event between 60 and 70 kya. Genetic evidence shows that occupation of the Near East and Europe happened no earlier than 50 kya. Studying haplogroup U has shown separate dispersals from the Near East both into Europe and into North Africa. Much of the work done in archaeogenetics focuses on the Neolithic transition in Europe. Cavalli-Svorza's analysis of genetic-geographic patterns led him to conclude that there

2226-402: A specimen is collected from an archaeological site, DNA can be extracted through a series of processes. One of the more common methods utilizes silica and takes advantage of polymerase chain reactions in order to collect ancient DNA from bone samples. There are several challenges that add to the difficulty when attempting to extract ancient DNA from fossils and prepare it for analysis. DNA

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2332-467: A therapeutic blood transfusion . This can cause Rh disease or other forms of hemolytic disease of the newborn (HDN) in the current pregnancy and/or subsequent pregnancies. Sometimes this is lethal for the fetus; in these cases it is called hydrops fetalis . If a pregnant woman is known to have anti-D antibodies, the Rh blood type of a fetus can be tested by analysis of fetal DNA in maternal plasma to assess

2438-493: A trading network for the production and consumption of readily available resources. Archaeogenetics has been used to study the domestication of animals. By analyzing genetic diversity in domesticated animal populations researchers can search for genetic markers in DNA to give valuable insight about possible traits of progenitor species. These traits are then used to help distinguish archaeological remains between wild and domesticated specimens. The genetic studies can also lead to

2544-556: A transfusion of D-positive blood once, but this would cause sensitization to the D antigen, and a female patient would become at risk for hemolytic disease of the newborn . If a D-negative patient has developed anti-D antibodies, a subsequent exposure to D-positive blood would lead to a potentially dangerous transfusion reaction. Rh D-positive blood should never be given to D-negative women of child-bearing age or to patients with D antibodies, so blood banks must conserve Rh-negative blood for these patients. In extreme circumstances, such as for

2650-492: A variety of different fossils, they may be less effective in fossils that are not fresh (e.g. treated fossils for museums ). Also, contamination poses a risk for all DNA replication in general, and this method may result in misleading results if applied to contaminated material. Polymerase chain reaction is a process that can amplify segments of DNA and is often used on extracted ancient DNA. It has three main steps: denaturation , annealing , and extension. Denaturation splits

2756-399: A “pioneer colonization” model of European occupation, with incorporation of foraging populations into arriving Neolithic populations. Furthermore, analysis of ancient DNA, not just extant DNA, is shedding light on some issues. For instance, comparison of neolithic and mesolithic DNA has indicated that the development of dairying preceded widespread lactose tolerance. South Asia has served as

2862-446: Is a comparison of clinically relevant characteristics of antibodies against the main human blood group systems: Transfusion medicine is a specialized branch of hematology that is concerned with the study of blood groups, along with the work of a blood bank to provide a transfusion service for blood and other blood products. Across the world, blood products must be prescribed by a medical doctor (licensed physician or surgeon ) in

2968-466: Is a recent admixture of some Negrito groups with their local populations. Archaeogenetics has been used to better understand the populating of the Americas from Asia. Native American mtDNA haplogroups have been estimated to be between 15 and 20 kya, although there is some variation in these estimates. Genetic data has been used to propose various theories regarding how the Americas were colonized. Although

3074-403: Is also difficult due to the lack of repeatability caused by the uniqueness of specimens. Silica-based DNA extraction is a method used as a purification step to extract DNA from archaeological bone artifacts and yield DNA that can be amplified using polymerase chain reaction (PCR) techniques. This process works by using silica as a means to bind DNA and separate it from other components of

3180-535: Is called autotransfusion , which is always compatible with the patient. The procedure of washing a patient's own red blood cells goes as follows: The patient's lost blood is collected and washed with a saline solution. The washing procedure yields concentrated washed red blood cells. The last step is reinfusing the packed red blood cells into the patient. There are multiple ways to wash red blood cells. The two main ways are centrifugation and filtration methods. This procedure can be performed with microfiltration devices like

3286-411: Is continuously being split up. While the organism is alive these splits are repaired; however, once an organism has died, the DNA will begin to deteriorate without repair. This results in samples having strands of DNA measuring around 100 base pairs in length. Contamination is another significant challenge at multiple steps throughout the process. Often other DNA, such as bacterial DNA, will be present in

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3392-575: Is different in that it agglutinates with both A and B. This was the discovery of blood groups for which Landsteiner was awarded the Nobel Prize in Physiology or Medicine in 1930. (C was later renamed to O after the German Ohne , meaning without, or zero, or null. ) Another group (later named AB) was discovered a year later by Landsteiner's students Adriano Sturli and Alfred von Decastello without designating

3498-421: Is difficult because the bone fossilisation degrades and DNA is chemically modified, usually by bacteria and fungi in the soil. The best time to extract DNA from a fossil is when it is freshly out of the ground as it contains six times the DNA when compared to stored bones. The temperature of extraction site also affects the amount of obtainable DNA, evident by a decrease in success rate for DNA amplification if

3604-550: Is especially helpful when the morphology of the fossil is ambiguous. Apart from that, species identification can also be done by finding specific genetic markers in an aDNA sequence. For example, the American indigenous population is characterized by specific mitochondrial RFLPs and deletions defined by Wallace et al. aDNA comparison study can also reveal the evolutionary relationship between two species. The number of base differences between DNA of an ancient species and that of

3710-542: Is genetic evidence that Chad-speaking descendants of Nilo-Saharan speakers migrated from Sudan to Lake Chad about 8 kya. Genetic evidence has also indicated that non-African populations made significant contributions to the African gene pool. For example, the Saharan African Beja people have high levels of Middle-Eastern as well as East African Cushitic DNA. Analysis of mtDNA shows that modern humans occupied Eurasia in

3816-407: Is likely to occur, and death is a possibility. Antibodies can be highly active and can attack RBCs and bind components of the complement system to cause massive hemolysis of the transfused blood. Patients should ideally receive their own blood or type-specific blood products to minimize the chance of a transfusion reaction . It is also possible to use the patient's own blood for transfusion. This

3922-577: Is native to India. Analysis of mtDNA and NRY (non-recombining region of Y chromosome) sequences have indicated that the first major dispersal out of Africa went through Saudi Arabia and the Indian coast 50–100 kya, and a second major dispersal occurred 15–50 kya north of the Himalayas. Much work has been done to discover the extent of north-to-south and south-to-north migrations within Eastern Asia. Comparing

4028-522: Is quick-frozen to retain the labile clotting factors V and VIII , which are usually administered to patients who have a potentially fatal clotting problem caused by a condition such as advanced liver disease, overdose of anticoagulant , or disseminated intravascular coagulation (DIC). Units of packed red cells are made by removing as much of the plasma as possible from whole blood units. Clotting factors synthesized by modern recombinant methods are now in routine clinical use for hemophilia , as

4134-574: Is related to inborn differences between individuals or it is the result of some damage of bacterial kind. This was the first evidence that blood variation exists in humans. The next year, in 1901, he made a definitive observation that blood serum of an individual would agglutinate with only those of certain individuals. Based on this he classified human bloods into three groups, namely group A, group B, and group C. He defined that group A blood agglutinates with group B, but never with its own type. Similarly, group B blood agglutinates with group A. Group C blood

4240-400: Is that a person's ABO blood type is predictive of their personality , character , and compatibility with others . Researchers have established no scientific basis exists for blood type personality categorization, and studies have found no "significant relationship between personality and blood type, rendering the theory 'obsolete' and concluding that no basis exists to assume that personality

4346-465: Is that it requires overlapping primer pairs for ancient DNA due to the short sequences. There can also be “jumping PCR” which causes recombination during the PCR process which can make analyzing the DNA more difficult in inhomogeneous samples. DNA extracted from fossil remains is primarily sequenced using Massive parallel sequencing , which allows simultaneous amplification and sequencing of all DNA segments in

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4452-517: Is the second most significant blood-group system in human-blood transfusion with currently 50 antigens. The most significant Rh antigen is the D antigen, because it is the most likely to provoke an immune system response of the five main Rh antigens. It is common for D-negative individuals not to have any anti-D IgG or IgM antibodies, because anti-D antibodies are not usually produced by sensitization against environmental substances. However, D-negative individuals can produce IgG anti-D antibodies following

4558-724: Is through DNA hybridization . Single-stranded DNA segments of both species are allowed to form complementary pair bonding with each other. More closely related species have a more similar genetic makeup, and thus a stronger hybridization signal. Scholz et al. conducted southern blot hybridization on Neanderthal aDNA (extracted from fossil remain W-NW and Krapina). The results showed weak ancient human-Neanderthal hybridization and strong ancient human-modern human hybridization. The human-chimpanzee and neanderthal-chimpanzee hybridization are of similarly weak strength. This suggests that humans and neanderthals are not as closely related as two individuals of

4664-577: Is used over mitochondrial and chloroplast DNA because of its faster mutation rate as well as its intraspecific variation due to a higher consistency of polymorphism genetic markers . Findings in crop 'domestication genes' (traits that were specifically selected for or against) include Through the study of archaeogenetics in plant domestication, signs of the first global economy can also be uncovered. The geographical distribution of new crops highly selected in one region found in another where it would have not originally been introduced serve as evidence of

4770-601: The Rockefeller Institute for Medical Research in New York, and as a member of a committee of the National Research Council concerned with blood grouping suggested to substitute Janský's and Moss's systems with the letters O, A, B, and AB, first instroduced by Polish physician Ludwik Hirszfeld and German physician Emil von Dungern . There was another confusion on the use of O which was introduced in 1910. It

4876-632: The "Amur hunter-gatherers" (7,000–14,000 years ago), who carry Ancient Northeast Asian (ANA) ancestry. The Neo-Siberians contributed mainly to Neolithic and Bronze Age populations in the Baikal region, such as the Neolithic Baikal hunter-gatherers of the Kitoi culture (5,200–4,200 BCE), Late Neolithic/Bronze Age Yakutia , and Krasnoyarsk groups of Eastern Siberia and the Altai-Sayan region . They may be linked to

4982-430: The 1950s. During the 1940s, Boyd and Karl O. Renkonen independently discovered that lectins react differently to various blood types, after finding that the crude extracts of the lima bean and tufted vetch agglutinated the red blood cells from blood type A but not blood types B or O. This ultimately led to the disclosure of thousands of plants that contained these proteins. In order to examine racial differences and

5088-513: The 45 blood groups, and an individual's blood type is one of many possible combinations of blood-group antigens. Almost always, an individual has the same blood group for life, but very rarely an individual's blood type changes through addition or suppression of an antigen in infection , malignancy , or autoimmune disease . Another more common cause of blood type change is a bone marrow transplant . Bone-marrow transplants are performed for many leukemias and lymphomas , among other diseases. If

5194-518: The Altai Mountains of Siberia between 17.2 and 10.1 kya, after the LGM. Analysis of both mtDNA and Y-chromosome DNA reveals evidence of “small, founding populations.” Studying haplogroups has led some scientists to conclude that a southern migration into the Americas from one small population was impossible, although separate analysis has found that such a model is feasible if such a migration happened along

5300-566: The A− group is ABO type A and does not have the Rh (D) antigen. As with many other genetic traits, the distribution of ABO and Rh blood groups varies significantly between populations. While theories are still debated in the scientific community as to why blood types vary geographically and why they emerged in the first place, evidence suggests that the evolution of blood types may be driven by genetic selection for those types whose antigens confer resistance to particular diseases in certain regions – such as

5406-640: The Baikal regions, but which are most closely related to other ancient northern East Asians, such as the earlier expanding "Neo-Siberians" evident in the Early Neolithic Baikal region. In North Asia , an early branch of the Ancient Northern East Asian lineage in conjunction with the Ancient North Eurasians (ANE) resulted in the formation of the Ancient Paleo-Siberians (APS). In East Asia , an Ancient Northern East Asian lineage with

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5512-465: The DNA into two single strands at high temperatures. Annealing involves attaching primer strands of DNA to the single strands that allow Taq polymerase to attach to the DNA. Extension occurs when Taq polymerase is added to the sample and matches base pairs to turn the two single strands into two complete double strands. This process is repeated many times, and is usually repeated a higher number of times when used with ancient DNA . Some issues with PCR

5618-502: The Greek word arkhaios , meaning "ancient", and the term genetics , meaning "the study of heredity". The term archaeogenetics was conceived by archaeologist Colin Renfrew . In February 2021, scientists reported the oldest DNA ever sequenced was successfully retrieved from a mammoth dating back over a million years. Ludwik Hirszfeld was a Polish microbiologist and serologist who

5724-478: The Hemoclear filter. Risks can be further reduced by cross-matching blood, but this may be skipped when blood is required for an emergency. Cross-matching involves mixing a sample of the recipient's serum with a sample of the donor's red blood cells and checking if the mixture agglutinates , or forms clumps. If agglutination is not obvious by direct vision, blood bank technologist usually check for agglutination with

5830-530: The Neolithic. Most mtDNA's were “already established” among existing Mesolithic and Paleolithic groups. Most “control-region lineages” of modern European mtDNA are traced to a founder event of reoccupying northern Europe towards the end of the Last Glacial Maximum (LGM). One study of extant European mtDNA's suggest this reoccupation occurred after the end of the LGM, although another suggests it occurred before. Analysis of haplogroups V, H, and U5 support

5936-642: The Pathological-Anatomical Institute of the University of Vienna (now Medical University of Vienna ). In 1900, he found that blood sera from different persons would clump together (agglutinate) when mixed in test tubes, and not only that, some human blood also agglutinated with animal blood. He wrote a two-sentence footnote: The serum of healthy human beings not only agglutinates animal red cells, but also often those of human origin, from other individuals. It remains to be seen whether this appearance

6042-883: The Rh system as C, c, E and e and for other blood group systems with a known risk for immunization such as the Kell system in particular for females of child-bearing age or patients with known need for many transfusions. Blood plasma compatibility is the inverse of red blood cell compatibility. Type AB plasma carries neither anti-A nor anti-B antibodies and can be transfused to individuals of any blood group; but type AB patients can only receive type AB plasma. Type O carries both antibodies, so individuals of blood group O can receive plasma from any blood group, but type O plasma can be used only by type O recipients. Table note 1. Assuming absence of strong atypical antibodies in donor plasma Rh D antibodies are uncommon, so generally neither D negative nor D positive blood contain anti-D antibodies. If

6148-512: The Y-chromosome lineages indicate that primarily males partook in these migrations. The discovery of two subbranches U2i and U2e of the U mtDNA lineage, which arose in Central Asia has “modulated” views of a large migration from Central Asia into India, as the two branches diverged 50 kya. Furthermore, U2e is found in large percentages in Europe but not India, and vice versa for U2i, implying U2i

6254-468: The antibody A and antigen B agglutinates the antibody B). Thus, transfusion can be considered safe as long as the serum of the recipient does not contain antibodies for the blood cell antigens of the donor. The ABO system is the most important blood-group system in human-blood transfusion. The associated anti-A and anti-B antibodies are usually immunoglobulin M , abbreviated IgM , antibodies. It has been hypothesized that ABO IgM antibodies are produced in

6360-414: The chemical composition of bone and soil, and hydrology . There are three perseveration diagenetic phases. The first phase is bacterial putrefaction , which is estimated to cause a 15-fold degradation of DNA. Phase 2 is when bone chemically degrades, mostly by depurination . The third diagenetic phase occurs after the fossil is excavated and stored, in which bone DNA degradation occurs most rapidly. Once

6466-458: The classification of blood groups has been generally accepted, and recommends that this nomenclature shall be adopted for international use as follows: 0 A B AB. To facilitate the change from the nomenclature hitherto employed the following is suggested: This classification became widely accepted and after the early 1950s it was universally followed. Hirszfeld and Dungern discovered the inheritance of blood types as Mendelian genetics in 1910 and

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6572-455: The coasts. Finally, archaeogenetics has been used to study the occupation of Australia and New Guinea. The Indigenous people of Australia and New Guinea are phenotypically very similar, but mtDNA has shown that this is due to convergence from living in similar conditions. Non-coding regions of mt-DNA have shown “no similarities” between the aboriginal populations of Australia and New Guinea. Furthermore, no major NRY lineages are shared between

6678-601: The continent found 14 genetic and linguistic “clusters,” suggesting an ancient geographic structure to African populations. In general, genotypic and phenotypic analysis have shown “large and subdivided throughout much of their evolutionary history.” Genetic analysis has supported archaeological hypotheses of a large-scale migrations of Bantu speakers into Southern Africa approximately 5 kya. Microsatellite DNA, single nucleotide polymorphisms (SNPs), and insertion/deletion polymorphisms (INDELS) have shown that Nilo-Saharan speaking populations originate from Sudan. Furthermore, there

6784-415: The development of domestication of dogs. Genetic studies have shown that all dogs are descendants from the gray wolf, however, it is currently unknown when, where, and how many times dogs were domesticated. Some genetic studies have indicated multiple domestications while others have not. Archaeological findings help better understand this complicated past by providing solid evidence about the progression of

6890-538: The distribution and migration patterns of various racial groups, Boyd systematically collected and classified blood samples from around the world, leading to his discovery that blood groups are not influenced by the environment, and are inherited. In his book Genetics and the Races of Man (1950), Boyd categorized the world population into 13 distinct races, based on their different blood type profiles and his idea that human races are populations with differing alleles . One of

6996-422: The domestication of dogs. As early humans domesticated dogs the archaeological remains of buried dogs became increasingly more abundant. Not only does this provide more opportunities for archaeologists to study the remains, it also provides clues about early human culture. [REDACTED] Evolutionary biology portal [REDACTED] History portal Blood group A blood type (also known as

7102-695: The donor HSCs. Provided the donor had a different ABO type, the new cells' surface antigens will be different from those on the surface of the patient's original red blood cells. Some blood types are associated with inheritance of other diseases; for example, the Kell antigen is sometimes associated with McLeod syndrome . For another example, Von Willebrand disease may be more severe or apparent in people with blood type O. Certain blood types may affect susceptibility to infections. For example, people with blood type O may be less susceptible to pro-thrombotic events induced by COVID-19 or long covid . Another example being

7208-504: The early spread of Proto-Uralic speakers and, in conjunction with Ancient Paleo-Siberians , to Bronze Age Western Baikal hunter-gatherers of the Glazkovo culture (around 2,500 BCE), associated with early Yeniseian speakers . Ancient Northeast Asians (Amur ancestry), represented by Mesolithic Amur specimens (c. 7-14kya) and subsequent samples from Mongolia, expanded after the dispersal of "Neo-Siberian" like groups, and may be associated with

7314-853: The existence of sub-types of A in 1911. In 1927, Landsteiner, with Philip Levine , discovered the MN blood group system , and the P system . Development of the Coombs test in 1945, the advent of transfusion medicine , and the understanding of ABO hemolytic disease of the newborn led to discovery of more blood groups. As of October 2024 , the International Society of Blood Transfusion (ISBT) recognizes 47 blood groups. A popular pseudoscientific belief in Eastern Asian countries (especially in Japan and South Korea ) known as 血液型 ketsuekigata / hyeoraekhyeong

7420-578: The existence of two systems immediately created confusion and potential danger in medical practice. Moss's system was adopted in Britain, France, and the US, while Janský's was preferred in most other European countries and some parts of the US. It was reported that "The practically universal use of the Moss classification at that time was completely and purposely cast aside. Therefore in place of bringing order out of chaos, chaos

7526-486: The existing data on blood group gene frequencies, and largely contributing to the genetic map of the world through his investigation of blood groups in many populations. Mourant discovered the new blood group antigens of the Lewis , Henshaw , Kell , and Rhesus systems, and analyzed the association of blood groups and various other diseases. He also focused on the biological significance of polymorphisms . His work provided

7632-453: The first years of life by sensitization to environmental substances such as food, bacteria , and viruses , although blood group compatibility rules are applied to newborn and infants as a matter of practice. The original terminology used by Karl Landsteiner in 1901 for the classification was A/B/C; in later publications "C" became "O". Type O is often called 0 ( zero , or null ) in other languages. The Rh system (Rh meaning Rhesus )

7738-416: The fossil is found in warmer regions. A drastic change of a fossil's environment also affects DNA preservation. Since excavation causes an abrupt change in the fossil's environment, it may lead to physiochemical change in the DNA molecule. Moreover, DNA preservation is also affected by other factors such as the treatment of the unearthed fossil like (e.g. washing, brushing and sun drying), pH , irradiation ,

7844-433: The fossil process that inhibit PCR amplification. However, silica itself is also a strong PCR inhibitor , so careful measures must be taken to ensure that silica is removed from the DNA after extraction. The general process for extracting DNA using the silica-based method is outlined by the following: One of the main advantages of silica-based DNA extraction is that it is relatively quick and efficient, requiring only

7950-422: The foundation for archaeogenetics because it facilitated the separation of genetic evidence for biological relationships between people. This genetic evidence was previously used for that purpose. It also provided material that could be used to appraise the theories of population genetics . William Boyd was an American immunochemist and biochemist who became famous for his research on the genetics of race in

8056-517: The genetic diversity of northeastern groups with southeastern groups has allowed archaeologists to conclude many of the northeast Asian groups came from the southeast. The Pan-Asian SNP (single nucleotide polymorphism) study found “a strong and highly significant correlation between haplotype diversity and latitude,” which, when coupled with demographic analysis, supports the case for a primarily south-to-north occupation of East Asia. Archaeogenetics has also been used to study hunter-gatherer populations in

8162-403: The hair color and blood type had no correlation. In addition to that he observed that there was a decrease of blood group A from western Europe to India and the opposite for blood group B. He hypothesized that the east-to-west blood group ratio stemmed from two blood groups consisting of mainly A or B mutating from blood group O, and mixing through migration or intermingling. A majority of his work

8268-490: The identification of ancestors for domesticated animals. The information gained from genetics studies on current populations helps guide the Archaeologist's search for documenting these ancestors. Archaeogenetics has been used to trace the domestication of pigs throughout the old world. These studies also reveal evidence about the details of early farmers. Methods of Archaeogenetics have also been used to further understand

8374-443: The major early corridor for geographical dispersal of modern humans from out-of-Africa. Based on studies of mtDNA line M, some have suggested that the first occupants of India were Austro-Asiatic speakers who entered about 45–60 kya. The Indian gene pool has contributions from earliest settlers, as well as West Asian and Central Asian populations from migrations no earlier than 8 kya. The lack of variation in mtDNA lineages compared to

8480-545: The most abundant information sources regarding inheritable traits linked to race remains the study of blood groups. Fossil retrieval starts with selecting an excavation site . Potential excavation sites are usually identified with the mineralogy of the location and visual detection of bones in the area. However, there are more ways to discover excavation zones using technology such as field portable x-ray fluorescence and Dense Stereo Reconstruction. Tools used include knives , brushes , and pointed trowels which assist in

8586-456: The most widely held theory suggests “three waves” of migration after the LGM through the Bering Strait, genetic data have given rise to alternative hypotheses. For example, one hypothesis proposes a migration from Siberia to South America 20–15 kya and a second migration that occurred after glacial recession. Y-chromosome data has led some to hold that there was a single migration starting from

8692-617: The name (simply referring it to as "no particular type"). Thus, after Landsteiner, three blood types were initially recognised, namely A, B, and C. Czech serologist Jan Janský was the first to recognise and designate four blood types in 1907 that he published in a local journal, using the Roman numerical I, II, III, and IV (corresponding to modern O, A, B, and AB respectively). Unknown to Janský, American physician William L. Moss introduced an almost identical classification in 1910, but with Moss's I and IV corresponding to Janský's IV and I. Thus

8798-428: The original sample. To avoid contamination it is necessary to take many precautions such as separate ventilation systems and workspaces for ancient DNA extraction work. The best samples to use are fresh fossils as uncareful washing can lead to mold growth. DNA coming from fossils also occasionally contains a compound that inhibits DNA replication. Coming to a consensus on which methods are best at mitigating challenges

8904-549: The plasma fraction of a blood transfusion may carry donor antibodies not found in the recipient, a significant reaction is unlikely because of dilution. Additionally, red blood cell surface antigens other than A, B and Rh D, might cause adverse reactions and sensitization, if they can bind to the corresponding antibodies to generate an immune response. Transfusions are further complicated because platelets and white blood cells (WBCs) have their own systems of surface antigens, and sensitization to platelet or WBC antigens can occur as

9010-420: The prediction of a phenotype based on the knowledge of the molecular basis of the currently known antigens. This allows a more detailed determination of the blood type and therefore a better match for transfusion, which can be crucial in particular for patients with needs for many transfusions to prevent allo-immunization. Blood types were first discovered by an Austrian physician, Karl Landsteiner , working at

9116-572: The prevalence of blood type O in malaria-endemic countries where individuals of blood type O exhibit the highest rates of survival. As of 31 December 2022, 42 blood-group systems have been identified by the International Society for Blood Transfusion in addition to the ABO and Rh systems. Thus, in addition to the ABO antigens and Rh antigens, many other antigens are expressed on the RBC surface membrane. For example, an individual can be AB, D positive, and at

9222-409: The rarity of this blood type in the rest of the population can result in a shortage of Duffy-negative blood for these patients. Similarly, for RhD negative people there is a risk associated with travelling to parts of the world where supplies of RhD negative blood are rare, particularly East Asia , where blood services may endeavor to encourage Westerners to donate blood. A pregnant woman may carry

9328-554: The recipient's anti-A and anti-B antibodies to transfused red blood cells, and also possible sensitization to Rh D antigens. One exception is individuals with hh antigen system (also known as the Bombay phenotype) who can only receive blood safely from other hh donors, because they form antibodies against the H antigen present on all red blood cells. Blood donors with exceptionally strong anti-A, anti-B or any atypical blood group antibody may be excluded from blood donation. In general, while

9434-486: The red blood cells and the antibodies in the serum . Regarding the antigen property of the blood all human beings can be classified into four groups, those with antigen A (group A), those with antigen B (group B), those with both antigen A and B (group AB) and those with neither antigen (group O). The antibodies present together with the antigens are found as follows: There is an agglutination reaction between similar antigen and antibody (for example, antigen A agglutinates

9540-763: The region, such as the Ainu from Japan and Negrito groups in the Philippines. For example, the Pan-Asian SNP study found that Negrito populations in Malaysia and the Negrito populations in the Philippines were more closely related to non-Negrito local populations than to each other, suggesting Negrito and non-Negrito populations are linked by one entry event into East Asia; although other Negrito groups do share affinities, including with Indigenous Australians . A possible explanation of this

9646-608: The removal of fossils from the earth. To avoid contaminating the ancient DNA , specimens are handled with gloves and stored in -20 °C immediately after being unearthed. Ensuring that the fossil sample is analyzed in a lab that has not been used for other DNA analysis could prevent contamination as well. Bones are milled to a powder and treated with a solution before the polymerase chain reaction (PCR) process. Samples for DNA amplification may not necessarily be fossil bones. Preserved skin, salt-preserved or air-dried, can also be used in certain situations. DNA preservation

9752-509: The resistance to specific malaria species seen in individuals lacking the Duffy antigen . The Duffy antigen, presumably as a result of natural selection , is less common in population groups from areas having a high incidence of malaria. The ABO blood group system involves two antigens and two antibodies found in human blood. The two antigens are antigen A and antigen B. The two antibodies are antibody A and antibody B. The antigens are present on

9858-672: The risk to the fetus of Rh disease. One of the major advances of twentieth century medicine was to prevent this disease by stopping the formation of Anti-D antibodies by D negative mothers with an injectable medication called Rho(D) immune globulin . Antibodies associated with some blood groups can cause severe HDN, others can only cause mild HDN and others are not known to cause HDN. To provide maximum benefit from each blood donation and to extend shelf-life, blood banks fractionate some whole blood into several products. The most common of these products are packed RBCs, plasma , platelets , cryoprecipitate , and fresh frozen plasma (FFP). FFP

9964-403: The risks of infection transmission that occur with pooled blood products are avoided. Table note 1. Assumes absence of atypical antibodies that would cause an incompatibility between donor and recipient blood, as is usual for blood selected by cross matching. An Rh D-negative patient who does not have any anti-D antibodies (never being previously sensitized to D-positive RBCs) can receive

10070-505: The same species are, but they are more related to each other than to chimpanzees. There have also been some attempts to decipher aDNA to provide valuable phenotypic information of ancient species. This is always done by mapping aDNA sequence onto the karyotype of a well-studied closely related species, which share a lot of similar phenotypic traits. For example, Green et al. compared the aDNA sequence from Neanderthal Vi-80 fossil with modern human X and Y chromosome sequence, and they found

10176-473: The same time M and N positive ( MNS system ), K positive ( Kell system ), Le or Le negative ( Lewis system ), and so on, being positive or negative for each blood group system antigen. Many of the blood group systems were named after the patients in whom the corresponding antibodies were initially encountered. Blood group systems other than ABO and Rh pose a potential, yet relatively low, risk of complications upon mixing of blood from different people. Following

10282-606: The splitting event between the two groups was over 50 kya, casting doubt on recent common ancestry between the two. Archaeogenetics has been used to understand the development of domestication of plants and animals. The combination of genetics and archeological findings have been used to trace the earliest signs of plant domestication around the world. However, since the nuclear, mitochondrial, and chloroplast genomes used to trace domestication's moment of origin have evolved at different rates, its use to trace genealogy have been somewhat problematic. Nuclear DNA in specific

10388-535: The spread of Turkic , Mongolic , and Tungusic speakers . The ANEA lineage is represented by a late Paleolithic specimen (c. 19kya) from the Amur region (Amur19k), as well as Early Neolithic samples including the Yumin, Devil's Gate (Far East Russia, ~7.7 kya), Shandong (coastal China, ~9.5-7.5 kya) and Lake Baikal (southern Siberia, ~7.1-6.3 kya) individuals. Archaeogenetics Archaeogenetics receives its name from

10494-478: The two populations. The high frequency of a single NRY lineage unique to Australia coupled with “low diversity of lineage-associated Y-chromosomal short tandem repeat (Y-STR) haplotypes” provide evidence for a “recent founder or bottleneck” event in Australia. But there is relatively large variation in mtDNA, which would imply that the bottleneck effect impacted males primarily. Together, NRY and mtDNA studies show that

10600-499: The “ Ancient Northeast Asians “ (ANA), “Neo-Siberians", and "Yellow River farmers". The ANEA are to be distinguished from the namely similar "Ancient Northeast Asian" (ANA) lineage, which is alternatively also known as "Amur ancestry", and which forms a sub-group of the ANEA grouping, specifically ancestral to hunter-gatherer people of the 7th-4th millennia before present, in the Amur region and later expanding to far-eastern Siberia, Mongolia and

10706-401: Was a massive influx of Near Eastern populations into Europe at the start of the Neolithic. This view led him “to strongly emphasize the expanding early farmers at the expense of the indigenous Mesolithic foraging populations.” mtDNA analysis in the 1990s, however, contradicted this view. M.B. Richards estimated that 10–22% of extant European mtDNA's had come from Near Eastern populations during

10812-510: Was found to be powerful in analyses of aDNA because it avoids potential loss of sample, substrate competition for templates, and error propagation in replication. The most common way to analyze an aDNA sequence is to compare it with a known sequence from other sources, and this could be done in different ways for different purposes. The identity of the fossil remain can be uncovered by comparing its DNA sequence with those of known species using software such as BLASTN. This archaeogenetic approach

10918-633: Was increased in the larger cities." To resolve the confusion, the American Association of Immunologists , the Society of American Bacteriologists , and the Association of Pathologists and Bacteriologists made a joint recommendation in 1921 that the Jansky classification be adopted based on priority. But it was not followed particularly where Moss's system had been used. In 1927, Landsteiner, who had moved to

11024-627: Was never clear whether it was meant for the figure 0, German null for zero or the upper case letter O for ohne , meaning without; Landsteiner chose the latter. In 1928 the Permanent Commission on Biological Standardization adopted Landsteiner's proposal and stated: The Commission learns with satisfaction that, on the initiative of the Health Organization of the League of Nations, the nomenclature proposed by von Dungern and Hirszfeld for

11130-473: Was researching the links of blood types to sex, disease, climate, age, social class, and race. His work led him to discover that peptic ulcer was more dominant in blood group O, and that AB blood type mothers had a high male-to-female birth ratio. Arthur Mourant was a British hematologist and chemist . He received many awards, most notably Fellowship of the Royal Society . His work included organizing

11236-647: Was the President of the Blood Group Section of the Second International Congress of Blood Transfusion. He founded blood group inheritance with Erich von Dungern in 1910, and contributed to it greatly throughout his life. He studied ABO blood groups . In one of his studies in 1919, Hirszfeld documented the ABO blood groups and hair color of people at the Macedonian front, leading to his discovery that

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