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71-638: For the state of fatigue, see Weariness . [REDACTED] Look up weary in Wiktionary, the free dictionary. Weary is a surname, and may refer to: Jake Weary (born 1990), American actor, musician, singer-songwriter and music producer Fred Weary (offensive lineman) (born 1977), American football guard Fred Weary (defensive back) (born 1974), former American football cornerback Emily Pohl-Weary (born 1973), Canadian novelist, professor and editor [REDACTED] Surname list This page lists people with

142-592: A career . Throughout history, work has been intimately connected with other aspects of society and politics , such as power , class , tradition , rights , and privileges . Accordingly, the division of labour is a prominent topic across the social sciences as both an abstract concept and a characteristic of individual cultures. Work may also present a threat to individual human happiness and survival, either through dirty, dangerous, and demeaning occupations or in extreme cases, from death by overwork . Some people have also engaged in critique of work and expressed

213-806: A corporate entity, the same workers can claim a larger share of the value created by their labor. While a union does require workers to sacrifice some autonomy in relation to their coworkers, it can grant workers more control over the work process itself in addition to material benefits. The need for planning and coordination extends beyond individual organizations to society as a whole too. Every successful work project requires effective resource allocation to provide necessities, materials, and investment (such as equipment and facilities). In smaller, traditional societies, these aspects can be mostly regulated through custom , though as societies grow, more extensive methods become necessary. These complex institutions, however, still have roots in common human activities. Even

284-478: A family setting, like parenting or housekeeping . In some cases, the distinction between work and other activities is simply a matter of common sense within a community. However, an alternative view is that labeling any activity as work is somewhat subjective, as Mark Twain expressed in the "whitewashed fence" scene of The Adventures of Tom Sawyer . Humans have varied their work habits and attitudes over time. As humans are diurnal , they work mainly during

355-530: A work ethic where work itself is seen as virtuous. For example, German sociologist Max Weber hypothesized that European capitalism originated in a Protestant work ethic , which emerged with the Reformation . Many Christian theologians appeal to the Old Testament 's Book of Genesis in regards to work. According to Genesis 1 , human beings were created in the image of God , and according to Genesis 2, Adam

426-486: A 2019 review was inconclusive as to whether cytokines play any definitive role in ME/CFS . Fatigue has been correlated with reductions in structural and functional connectivity in the brain. This has included in post-stroke, MS, NMOSD and MOG, and ME/CFS. This was also found for fatigue after brain injury, including a significant linear correlation between self-reported fatigue and brain functional connectivity. Areas of

497-451: A broad range of brain networks, and has been linked to many types of fatigue. Findings implicate neuroinflammation in the etiology of fatigue in autoimmune and related disorders. Low-grade inflammation may cause an imbalance between energy availability and expenditure. Cytokines are small protein molecules that modulate immune responses and inflammation (as well as other functions) and may have causal roles in fatigue. However

568-733: A car crash, and being awake over 20 hours is the equivalent of driving with a blood-alcohol concentration level of 0.08%. People with multiple sclerosis experience a form of overwhelming tiredness that can occur at any time of the day, for any duration, and that does not necessarily recur in a recognizable pattern for any given patient, referred to as "neurological fatigue", and often as "multiple sclerosis fatigue" or "lassitude". People with autoimmune diseases including inflammatory rheumatic diseases such as rheumatoid arthritis , psoriatic arthritis and primary Sjögren's syndrome , experience similar fatigue. Attempts have been made to isolate causes of central nervous system fatigue . Acute fatigue

639-439: A diagnosis that could explain the fatigue after a year with the condition. In those people who had a possible diagnosis, musculoskeletal (19.4%) and psychological problems (16.5%) were the most common. Definitive physical conditions were only found in 8.2% of cases. Fatigue can be seen as a uni-dimensional phenomenon that influences different aspects of human life. It can be multi-faceted and broadly defined, making understanding

710-554: A highly-repetitive set of simple actions, like in mass manufacturing , complex machines can carry out much of the effort. The workers present will focus on more complex tasks, operating controls, or performing maintenance . Over several millennia, invention , scientific discovery , and engineering principles have allowed humans to proceed from creating simple machines that merely redirect or amplify force , through engines for harnessing supplementary power sources, to today's complex, regulated systems that automate many steps within

781-404: A hostile workplace. Particularly intense forms of manual labor often lead workers to develop physical strength necessary for their job. However, this activity does not necessarily improve a worker's overall physical fitness like exercise , due to problems like overwork or a small set of repetitive motions. In these physical jobs, maintaining good posture or movements with proper technique

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852-476: A lack of energy in the muscle, by a decrease of the efficiency of the neuromuscular junction or by a reduction of the drive originating from the central nervous system , and can be reversed by rest. The central component of fatigue is triggered by an increase of the level of serotonin in the central nervous system. During motor activity, serotonin released in synapses that contact motor neurons promotes muscle contraction . During high level of motor activity,

923-442: A medical context is used to cover experiences of low energy that are not caused by normal life. A 2021 review proposed a definition for fatigue as a starting point for discussion: "A multi-dimensional phenomenon in which the biophysiological, cognitive, motivational and emotional state of the body is affected resulting in significant impairment of the individual's ability to function in their normal capacity" . Another definition

994-512: A narrow range of jobs, inherited from parent to child. In serfdom , a peasant has more rights than a slave but is attached to a specific piece of land and largely under the power of the landholder , even requiring permission to physically travel outside the land-holding. How institutions play out in individual workers' lives can be complex too; in most societies where wage-labor predominates, workers possess equal rights by law and mobility in theory. Without social support or other resources, however,

1065-424: A number of smaller hand-tools, designed to be held and operated by a single person, often without supplementary power . This is especially true when tasks can be handled by one or a few workers, do not require significant physical power, and are somewhat self-paced, like in many services or handicraft manufacturing. For other tasks needing large amounts of power, such as in the construction industry, or involving

1136-435: A particular goal. Because sustained effort is a necessary part of many human activities, what qualifies as work is often a matter of context. Specialization is one common feature that distinguishes work from other activities. For example, a sport is a job for a professional athlete who earns their livelihood from it, but a hobby for someone playing for fun in their community. An element of advance planning or expectation

1207-507: A patient, with the relative contribution of each mechanism differing over time. Proposed fatigue explanations due to permanent changes in the brain may have difficulty in explaining the "unpredictability" and "variability" (i.e. appearing intermittently during the day, and not on all days) of the fatigue associated with inflammatory rheumatic diseases and autoimmune diseases (such as multiple sclerosis ). Inflammation distorts neural chemistry, brain function and functional connectivity across

1278-500: A person who is sufficiently somnolent may experience microsleep . However, objective cognitive testing can be used to differentiate the neurocognitive deficits of brain disease from those attributable to tiredness. The perception of mental fatigue is believed to be modulated by the brain's reticular activating system (RAS). Fatigue impacts a driver's reaction time, awareness of hazards around them and their attention. Drowsy drivers are three times more likely to be involved in

1349-525: A result of urbanization and industrialization , is unemployment . While the shift from a subsistence economy usually increases the overall productivity of society and lifts many out of poverty , it removes a baseline of material security from those who cannot find employment or other support. Governments have tried a range of strategies to mitigate the problem, such as improving the efficiency of job matching , conditionally providing welfare benefits or unemployment insurance , or even directly overriding

1420-493: A result of automation and the increasing adoption of artificial intelligence . For some, work may hold a spiritual value in addition to any secular notions. Especially in some monastic or mystical strands of several religions , simple manual labor may be held in high regard as a way to maintain the body, cultivate self-discipline and humility, and focus the mind. The contemporary world economy has brought many changes, overturning some previously widespread labor issues. At

1491-402: A sense, because of it", because work is something that corresponds to man's dignity and through it, he achieves fulfilment as a human being. The fall also means that a work ethic is needed. As a result of the fall, work has become subject to the abuses of idleness on the one hand, and overwork on the other. Drawing on Aristotle , Ryken suggests that the moral ideal is the golden mean between

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1562-458: A side effect of certain medications (e.g., lithium salts , ciprofloxacin ); beta blockers , which can induce exercise intolerance , medicines used to treat allergies or coughs, and many cancer treatments, particularly chemotherapy and radiotherapy . Use of benzodiazepines has been found to correlate with higher fatigue. Fatigue is often associated with diseases and conditions. Some major categories of conditions that often list fatigue as

1633-416: A single industry. Some industries may be seen as more prestigious than others overall, even if they include roles with similar functions. At the same time, a wide swathe of roles across all industries may be afforded more status (e.g. managerial roles) or less (like manual labor ) based on characteristics such as a job being low-paid or dirty, dangerous and demeaning . Other social dynamics, like how labor

1704-520: A symptom include physical diseases, substance use illness, mental illnesses, and other diseases and conditions. In some areas, it has been proposed that fatigue be separated into primary fatigue, caused directly by a disease process, and ordinary or secondary fatigue, caused by a range of causes including exertion and also secondary impacts on a person of having a disease (such as disrupted sleep). The ICD-11 MG22 definition of fatigue captures both types of fatigue; it includes fatigue that "occur[s] in

1775-469: A tendency to fall asleep, whereas fatigue refers to an overwhelming sense of tiredness, lack of energy, and a feeling of exhaustion. Sleepiness and fatigue often coexist as a consequence of sleep deprivation. However sleepiness and fatigue may not correlate. Fatigue is generally considered a longer-term condition than sleepiness (somnolence). Distinguishing features of medical fatigue include Differentiating characteristics of fatigue that may help identify

1846-464: A tendency to higher concentrations of HSP72. A small 2020 study of Crohn's disease patients found that higher fatigue visual analogue scale (fVAS) scores correlated with hgher HSP90α levels. A related small 2012 trial investigating if application of an IL-1 receptor antagonist ( anakinra ) would reduce fatigue in primary Sjögren's syndrome patients was inconclusive. Fatigue is currently measured by many different self-measurement surveys. Examples are

1917-401: A third of fatigue primary care cases, no medical or psychiatric diagnosis is found. Tiredness is a common medically unexplained symptom. Fatigue can often be traced to poor sleep habits. Sleep deprivation and disruption is associated with subsequent fatigue. Sleep disturbances due to disease may impact fatigue. Caffeine and alcohol can disrupt sleep, causing fatigue. Fatigue may be

1988-528: A wish to reduce or abolish it entirely, for example in Paul Lafargue in his book The Right to Be Lazy , David Graeber 's Bullshit Jobs , or The Abolition of Work by Bob Black. Real world programs to eliminate the economic necessity for lifelong work first emerged through the concept of retirement , and have more recently been extended to all adults through experimentation with universal basic income . Work can take many different forms, as varied as

2059-560: A work process. In the 20th century, the development of electronics and new mathematical insights led to the creation and widespread adoption of fast, general-purpose computers . Just as mechanization can substitute for the physical labor of many human beings, computers allow for the partial automation of mental work previously carried out by human workers, such as calculations , document transcription , and basic customer service requests. Research and development of related technologies like machine learning and robotics continues into

2130-430: Is a self-reported, persistent (constant) fatigue lasting at least one month. Work (human activity) Work has existed in all human societies, either as paid or unpaid work , from gathering natural resources by hand in hunter-gatherer groups to operating complex technologies that substitute for physical or even mental effort within an agricultural , industrial , or post-industrial society . All but

2201-494: Is also a crucial skill for avoiding injury . Ironically, white-collar workers who are sedentary throughout the workday may also suffer from long-term health problems due to a lack of physical activity. Learning the necessary skills for work is often a complex process in its own right, requiring intentional training . In traditional societies, know-how for different tasks can be passed to each new generation through oral tradition and working under adult guidance. For work that

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2272-428: Is also common, such as when a paramedic provides medical care while on duty and fully equipped rather than performing first aid off-duty as a bystander in an emergency. Self-care and basic habits like personal grooming are also not typically considered work. While a later gift , trade , or payment may retroactively affirm an activity as productive, this can exclude work like volunteering or activities within

2343-527: Is closely linked to the concept of ego depletion , though the validity of the concept is disputed. For example, one pre-registered study of 686 participants found that after exerting mental effort, people are likely to disengage and become less interested in exerting further effort. Decreased attention can also be described as a more or less decreased level of consciousness . In any case, this can be dangerous when performing tasks that require constant concentration, such as operating large vehicles. For instance,

2414-420: Is compensated, can even exclude meaningful tasks from a society's conception of work. For example, in modern market-economies where wage labor or piece work predominates, unpaid work may be omitted from economic analysis or even cultural ideas of what qualifies as work. At a political level, different roles can fall under separate institutions where workers have qualitatively different power or rights. In

2485-545: Is complex and in up to a third of primary care cases no medical or psychiatric diagnosis is found. Fatigue (in the general usage sense of normal tiredness) often follows prolonged physical or mental activity. Physical fatigue results from muscle fatigue brought about by intense physical activity . Mental fatigue results from prolonged periods of cognitive activity which impairs cognitive ability, can manifest as sleepiness , lethargy , or directed attention fatigue , and can also impair physical performance. Fatigue in

2556-454: Is different from Wikidata All set index articles Weariness Fatigue describes a state of tiredness (which is not sleepiness), exhaustion or loss of energy. Fatigue (in the medical sense) is sometimes associated with medical conditions including autoimmune disease , organ failure , chronic pain conditions, mood disorders , heart disease , infectious diseases , and post-infectious-disease states. However, fatigue

2627-442: Is more specialized and technically complex, however, a more formal system of education is usually necessary. A complete curriculum ensures that a worker in training has some exposure to all major aspects of their specialty, in both theory and practice . Tool use has been a central aspect of human evolution and is also an essential feature of work. Even in technologically advanced societies, many workers' toolsets still include

2698-546: Is not enough to diagnose most neuromuscular disorders. Mental fatigue is a temporary inability to maintain optimal cognitive performance. The onset of mental fatigue during any cognitive activity is gradual, and depends upon an individual's cognitive ability, and also upon other factors, such as sleep deprivation and overall health. Mental fatigue has also been shown to decrease physical performance. It can manifest as somnolence , lethargy , directed attention fatigue , or disengagement. Research also suggests that mental fatigue

2769-432: Is ranking them according to a criterion, such as the amount of skill, experience , or seniority associated with a role. The progression from apprentice through journeyman to master craftsman in the skilled trades is one example with a long history and analogs in many cultures. Societies also commonly rank different work roles by perceived status, but this is more subjective and goes beyond clear progressions within

2840-646: Is required for any effort outside of individual subsistence to succeed. At the level of a small team working on a single task, only cooperation and good communication may be necessary. As the complexity of a work process increases though, requiring more planning or more workers focused on specific tasks, a reliable organization becomes more critical. Economic organizations often reflect social thought common to their time and place, such as ideas about human nature or hierarchy . These unique organizations can also be historically significant, even forming major pillars of an economic system . In European history, for instance,

2911-402: Is that fatigue is "a significant subjective sensation of weariness, increasing sense of effort, mismatch between effort expended and actual performance, or exhaustion independent from medications, chronic pain, physical deconditioning, anaemia , respiratory dysfunction, depression , and sleep disorders" . The use of the term "fatigue" in medical contexts may carry inaccurate connotations from

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2982-444: Is that which is temporary and self-limited. Acute fatigue is most often caused by an infection such as the common cold and can be cognized as one part of the sickness behavior response occurring when the immune system fights an infection . Other common causes of acute fatigue include depression and chemical causes, such as dehydration , poisoning , low blood sugar , or mineral or vitamin deficiencies. Prolonged fatigue

3053-494: Is the three-sector model or variations of it. In this view, an economy can be separated into three broad categories: In complex economies with high specialization, these categories are further subdivided into industries that produce a focused subset of products or services. Some economists also propose additional sectors such as a "knowledge-based" quaternary sector , but this division is neither standardized nor universally accepted. Another common way of contrasting work roles

3124-407: Is the ground because of you; in pain you shall eat of it all the days of your life". Leland Ryken said out that, because of the fall, "many of the tasks we perform in a fallen world are inherently distasteful and wearisome." Christian theologians interpret that through the fall, work has become toil, but John Paul II says that work is a good thing for man in spite of this toil, and that "perhaps, in

3195-424: Is wrong since this encourages illiteracy, inhumane work and lower investment in human capital. In other words, there are moral and economic reasons that justify a blanket ban on labour from children aged 18 years or less, everywhere in the world. On the other hand, some scholars like Christiaan Grootaert and Kameel Ahmady believe that child labour is the symptom of poverty. If laws ban most lawful work that enables

3266-420: The free markets of modern capitalist societies rely fundamentally on trade , while command economies , such as in many communist states during the 20th century, rely on a highly bureaucratic and hierarchical form of redistribution . Other institutions can affect workers even more directly by delimiting practical day-to-day life or basic legal rights. For example, a caste system may restrict families to

3337-407: The surname Weary . If an internal link intending to refer to a specific person led you to this page, you may wish to change that link by adding the person's given name (s) to the link. Retrieved from " https://en.wikipedia.org/w/index.php?title=Weary&oldid=1009822795 " Category : Surnames Hidden categories: Articles with short description Short description

3408-451: The 21st century. Beyond tools and machines used to actively perform tasks, workers benefit when other passive elements of their work and environment are designed properly. This includes everything from personal items like workwear and safety gear to features of the workspace itself like furniture , lighting , air quality , and even the underlying architecture . Even if workers are personally ready to perform their jobs, coordination

3479-615: The Fatigue Symptom Inventory (FSI) and the Fatigue Severity Scale. There is no consensus on best practice, and the existing surveys do not capture the intermittent nature of some forms of fatigue. A 2023 guidance indicates the following A 2016 German review found that A 2014 Australian review recommended that a period of watchful waiting may be appropriate if there are no major warning signs. A 2009 study found that about 50% of people who had fatigue received

3550-568: The absence of... exertion... as a symptom of health conditions." Obesity correlates with higher fatigue levels and incidence. In somatic symptom disorder the patient is overfocused on a physical symptom, such as fatigue, that may or may not be explained by a medical condition. Adverse life events have been associated with fatigue. The concept of adrenal fatigue is often raised in media but no scientific basis has been found for it. The mechanisms that cause fatigue are not well understood. Several mechanisms may be in operation within

3621-529: The amount of serotonin released increases and a spillover occurs. Serotonin binds to extrasynaptic receptors located on the axonal initial segment of motor neurons with the result that nerve impulse initiation and thereby muscle contraction are inhibited. Muscle strength testing can be used to determine the presence of a neuromuscular disease , but cannot determine its cause. Additional testing, such as electromyography , can provide diagnostic information, but information gained from muscle strength testing alone

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3692-520: The brain for which there is evidence of relation to fatigue are the thalamus and middle frontal cortex, fronto-parietal and cingulo-opercular, and default mode network, salience network, and thalamocortical loop areas. A 2024 review found that structural connectivity changes may underlie fatigue in pwRRMS but that the overall results were inconclusive, possibly explained by heterogeneity and limited number of studies. A small 2023 study found that infratentorial lesion volume (cerebellar and brainstem)

3763-421: The causes of its manifestations especially difficult in conditions with diverse pathology including autoimmune diseases. A 2021 review considered that different "types/subsets" of fatigue may exist and that patients normally present with more than one such "type/subset". These different "types/subsets" of fatigue may be different dimensions of the same symptom, and the relative manifestations of each may depend on

3834-495: The creativity and adaptability of humans in their pursuit of livelihood. Individual workers require sufficient health and resources to succeed in their tasks. As living beings, humans require a baseline of good health, nutrition , rest, and other physical needs in order to reliably exert themselves. This is particularly true of physical labor that places direct demands on the body, but even largely mental work can cause stress from problems like long hours, excessive demands, or

3905-441: The day, but some occupations require night shift work. Hunter-gatherer societies vary their "work" intensity according to the seasonal availability of plants and the periodic migration of prey animals . The development of agriculture led to more sustained work practices, but work still changed with the seasons, with intense sustained effort during harvests (for example) alternating with less focused periods such as winters. In

3976-427: The decline of guilds and rise of joint-stock companies goes hand-in-hand with other changes, like the growth of centralized states and capitalism . In industrialized economies, labor unions are another significant organization. In isolation, a worker that is easily replaceable in the labor market has little power to demand better wages or conditions. By banding together and interacting with business owners as

4047-745: The deprived classes, the weakness of laws and legal supervision, the migration existence of child labour is very much observed in different parts of the world. According to the World Bank Globally rate of child labour have decreased from 25% to 10% between 60s to the early years of the 21st century. Nevertheless, giving the population of the world also increased the total number of child labourers remains high, with UNICEF and ILO acknowledging an estimated 168 million children aged 5–17 worldwide were involved in some sort of child labour in 2013. Some scholars like Jean-Marie Baland and James A. Robinson suggests any labour by children aged 18 years or less

4118-674: The early modern era, Protestantism and proto-capitalism emphasized the moral and personal advantages of hard work. The periodic re-invention of slavery encouraged more consistent work activity in the working class , and capitalist industrialization intensified demands on workers to keep up with the pace of machines. Restrictions on the hours of work and the ages of workers followed, with worker demands for time off increasing, but modern office work retains traces of expectations of sustained, concentrated work, even in affluent societies. There are several ways to categorize and compare different kinds of work. In economics, one popular approach

4189-406: The environments, tools, skills, goals, and institutions around a worker. This term refers to the general activity of performing tasks, whether they are paid or unpaid, formal or informal. Work encompasses all types of productive activities, including employment , household chores, volunteering, and creative pursuits. It is a broad term that encompasses any effort or activity directed towards achieving

4260-509: The extreme, the least powerful members of society may be stigmatized (as in untouchability ) or even violently forced (via slavery ) into performing the least desirable work. Complementary to this, elites may have exclusive access to the most prestigious work, largely symbolic sinecures , or even a "life of leisure ". Unusual Occupations In the diverse world of work, there exist some truly bizarre and unusual occupations that often defy conventional expectations. These unique jobs showcase

4331-444: The labor market through work-relief programs or a job guarantee . Since a job forms a major part of many workers' self-identity , unemployment can have severe psychological and social consequences beyond the financial insecurity it causes. One more issue, which may not directly interfere with the functioning of an economy but can have significant indirect effects, is when governments fail to account for work occurring out-of-view from

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4402-491: The more general usage of the same word. More accurate terminology may also be needed for variants within the umbrella term of fatigue. Tiredness which is a normal result of work , mental stress , anxiety , overstimulation and understimulation, jet lag , active recreation , boredom , or lack of sleep is not considered medical fatigue. This is the tiredness described in MeSH Descriptor Data. Sleepiness refers to

4473-416: The necessity of earning a livelihood may force a worker to cede some rights and freedoms in fact. Societies and subcultures may value work in general, or specific kinds of it, very differently. When social status or virtue is strongly associated with leisure and opposed to tedium, then work itself can become indicative of low social rank and be devalued. In the opposite case, a society may hold strongly to

4544-465: The possible cause of fatigue include Some people may have multiple causes of fatigue. A 2021 study in a Korean city found that alcohol consumption was the variable with the most correlation with overall fatigue. A 2020 Norway study found that 69% of substance use disorder patients had severe fatigue symptoms, and particularly those with extensive use of benzodiazepines . Causality, as opposed to correlation, were not proven in these studies. In up to

4615-422: The public sphere. This may be important, uncompensated work occurring everyday in private life; or it may be criminal activity that involves clear but furtive economic exchanges. By ignoring or failing to understand these activities, economic policies can have counter-intuitive effects and cause strains on the community and society. Due to various reasons such as the cheap labour , the poor economic situation of

4686-450: The relative contribution of different mechanisms. Inflammation may be the root causal mechanism in many cases. Physical fatigue, or muscle fatigue , is the temporary physical inability of muscles to perform optimally. The onset of muscle fatigue during physical activity is gradual, and depends upon an individual's level of physical fitness – other factors include sleep deprivation and overall health. Physical fatigue can be caused by

4757-474: The same time, some longstanding issues remain relevant, and other new ones have emerged. One issue that continues despite many improvements is slave labor and human trafficking . Though ideas about universal rights and the economic benefits of free labor have significantly diminished the prevalence of outright slavery, it continues in lawless areas, or in attenuated forms on the margins of many economies. Another difficulty, which has emerged in most societies as

4828-604: The simplest tasks in any work require specific skills , tools , and other resources, such as material for manufacturing goods. Humanity has developed a variety of institutions for group coordination of work, such as government programs , nonprofit organizations , cooperatives , and corporations . Cultures and individuals across history have expressed a wide range of attitudes towards work. Besides objective differences, one culture may organize or attach social status to work roles through formalized professions which may carry specialized job titles and provide people with

4899-611: The two extremes of being lazy and being a workaholic. Some Christian theologians also draw on the doctrine of redemption to discuss the concept of work. Oliver O'Donovan said that although work is a gift of creation, it is "ennobled into mutual service in the fellowship of Christ." Pope Francis is critical of the hope that technological progress might eliminate or diminish the need for work: "the goal should not be that technological progress increasingly replace human work, for this would be detrimental to humanity", and McKinsey consultants suggest that work will change, but not end, as

4970-538: Was a relatively good predictor of RRMS fatigue severity. Studies have found MS fatigue correlates with damage to NAWM (normal appearing white matter ) (which will not show on normal MRI but will show on DTI (diffusion tensor imaging) ). The correlation becomes unreliable in patients aged over 65 due to damage due to ageing. A small 2016 study found that primary Sjögren's syndrome patients with high fatigue, when compared with those with low fatigue, had significantly higher plasma concentrations of HSP90α , and

5041-542: Was placed in the Garden of Eden to "work it and keep it". Dorothy L. Sayers has argued that "work is the natural exercise and function of man – the creature who is made in the image of his Creator." Likewise, John Paul II said in Laborem exercens that by his work, man shares in the image of his creator. Christian theologians see the fall of man as profoundly affecting human work. In Genesis 3 :17, God said to Adam, "cursed

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