388610
4-483: 69539 ENSG00000253368 ENSMUSG00000056596 Q6NT89 Q80ZI1 NM_001013642 NM_001081156 NP_001013664 NP_001074625 TMF-regulated nuclear protein 1 is a nuclear protein that in humans is encoded by the TRNP1 gene . TRNP1 plays a crucial role in cellular proliferation and brain development . Trnp1 is the first protein that has been shown to play a major role in cortical folding . It represents
8-426: A biomarker for specific colon cancer subtypes. This protein -related article is a stub . You can help Misplaced Pages by expanding it . Nuclear protein A nuclear protein is a protein found in the cell nucleus . Proteins are transported inside the nucleus with the help of the nuclear pore complex , which acts a barrier between cytoplasm and nuclear membrane. The import and export of proteins through
12-455: A major stem cell factor, that is involved in crucial processes during brain but also stem cell development. Trnp1 controls gene expression levels and is sufficient to induce gyri and sulci in the developing brain. Local differences of Trnp1 expression levels in the human brain correlate with cortical folding. Trnp1 binds to DNA with high affinity. Its direct molecular function is unknown, it has no known molecular motif and therefore may represent
16-532: A new class of molecules. Trnp1 has a very strong effect on cellular proliferation , Trnp1 dramatically increases the proliferation rate in vitro an in vivo . In addition to its stem cell function during brain development, there are data suggesting that Trnp1 might play a crucial role in cancer cells - Trnp1 has been described in gene expression analysis in cancer types. the very strong proliferation capacity may be responsible for its oncogenic potential. Specifically, Trnp1 (together with other factors) serves as
#696303