The TBC domain is an evolutionarily conserved protein domain found in all eukaryotes . It is approximately 180 to 200 amino acids long. The domain is named for its initial discovery in the proteins T re-2 , B ub2 , and C dc16 .
18-616: [REDACTED] Look up TBC in Wiktionary, the free dictionary. TBC may refer to: Education [ edit ] Trinity Bible College in North Dakota, US Tauranga Boys' College , a state secondary school in Tauranga, New Zealand Companies [ edit ] Triangle Brewing Company of Durham, North Carolina, US Tram et Bus de la CUB (TBC), now Transports Bordeaux Métropole ,
36-401: A South Korean local broadcasting company Tohoku Broadcasting Company , a Sendai, Japan, TV/radio station Tonga Broadcasting Commission Tongyang Broadcasting Company , 1964–1980, a defunct South Korean broadcasting company Triad Broadcasting Company Music [ edit ] The Black Crowes , a blues based rock band TBC (band) , a Christian band Texas Boys Choir ,
54-401: A South Korean local broadcasting company Tohoku Broadcasting Company , a Sendai, Japan, TV/radio station Tonga Broadcasting Commission Tongyang Broadcasting Company , 1964–1980, a defunct South Korean broadcasting company Triad Broadcasting Company Music [ edit ] The Black Crowes , a blues based rock band TBC (band) , a Christian band Texas Boys Choir ,
72-557: A boychoir located in Fort Worth, Texas, US Other uses [ edit ] To be confirmed To be continued 4-tert-Butylcatechol , an antioxidant The Beijing Center for Chinese Studies , organization aiming at educating the academic community about China World of Warcraft: The Burning Crusade , the first expansion pack for World of Warcraft Thermal barrier coating , advanced materials systems usually applied to metallic surfaces operating at elevated temperatures, as
90-504: A boychoir located in Fort Worth, Texas, US Other uses [ edit ] To be confirmed To be continued 4-tert-Butylcatechol , an antioxidant The Beijing Center for Chinese Studies , organization aiming at educating the academic community about China World of Warcraft: The Burning Crusade , the first expansion pack for World of Warcraft Thermal barrier coating , advanced materials systems usually applied to metallic surfaces operating at elevated temperatures, as
108-634: A form of exhaust heat management Time base corrector , technique to reduce or eliminate errors caused by mechanical instability present in analog recordings Transcending Boundaries Conference , north-east US LGBTQI convention Treasury Board of Canada Tuba City Airport , Arizona IATA airport code Tucson Bird Count , a community-based biological monitoring program in Tucson, Arizona, US The Brothers Chaps , American writers, voice actors, directors, producers and composers True Blue Crew , Australian far-right white supremacist group TBC domain ,
126-585: A form of exhaust heat management Time base corrector , technique to reduce or eliminate errors caused by mechanical instability present in analog recordings Transcending Boundaries Conference , north-east US LGBTQI convention Treasury Board of Canada Tuba City Airport , Arizona IATA airport code Tucson Bird Count , a community-based biological monitoring program in Tucson, Arizona, US The Brothers Chaps , American writers, voice actors, directors, producers and composers True Blue Crew , Australian far-right white supremacist group TBC domain ,
144-488: A primary role as a Rab-GAP and conversely, not all Rab-GAP contain TBC. In addition, the fact that this family has been poorly studied makes it then further complicated. Phylogenetic analysis has provided insight into the evolution of the TBC family. ScrollSaw was implemented as a recent strategy to overcome poor resolution between TBC genes found in standard phylogenetic strategies during initial reconstructions. Significantly,
162-515: A protein domain named for its initial discovery in the proteins Tre-2, Bub2, and Cdc16 Topics referred to by the same term [REDACTED] This disambiguation page lists articles associated with the title TBC . If an internal link led you here, you may wish to change the link to point directly to the intended article. Retrieved from " https://en.wikipedia.org/w/index.php?title=TBC&oldid=1249917041 " Category : Disambiguation pages Hidden categories: Short description
180-515: A protein domain named for its initial discovery in the proteins Tre-2, Bub2, and Cdc16 Topics referred to by the same term [REDACTED] This disambiguation page lists articles associated with the title TBC . If an internal link led you here, you may wish to change the link to point directly to the intended article. Retrieved from " https://en.wikipedia.org/w/index.php?title=TBC&oldid=1249917041 " Category : Disambiguation pages Hidden categories: Short description
198-571: Is different from Wikidata All article disambiguation pages All disambiguation pages TBC [REDACTED] Look up TBC in Wiktionary, the free dictionary. TBC may refer to: Education [ edit ] Trinity Bible College in North Dakota, US Tauranga Boys' College , a state secondary school in Tauranga, New Zealand Companies [ edit ] Triangle Brewing Company of Durham, North Carolina, US Tram et Bus de la CUB (TBC), now Transports Bordeaux Métropole ,
SECTION 10
#1732854665477216-542: Is different from Wikidata All article disambiguation pages All disambiguation pages TBC domain TBC family members act as GTPase-activating proteins (GAPs) for small GTPases in regulating the cell cycle . For example, Rab activity is modulated in part by GAPs, and many RabGAPs share a Tre2/Bub2/Cdc16(TBC)-domain architecture, suggesting that TBC domain-containing proteins may behave similarly. USP6 and CDC16 contain TBC domains. In addition, all proteins in
234-509: The TBC domain and its substrate Rab. For instance Barr and his coworkers found a specific interaction between RUTBC3 /RabGAP-5 and Rab5A that activates the GTPase activity of Rab5 isoform. Similarly other research has shown that, among other important aspects, the TBC-Rab interaction alone is insufficient to determine the target of TBC proteins. However, there has been a second approach to identifying
252-456: The TBC domain is nearly always smaller than the Rab cohort in any individual genome , suggesting Rab/TBC coevolution. Twenty-one putative TBC sub-classes were founded and identified as a seven robust and two moderately supported clades . Moreover, there has also been systematic analysis in order to identify the target Rabs of TBC proteins. It was, at first, based on the physical interaction between
270-823: The TBC family contain this domain: TBC mainly functions as a specific Rab GAP (GTPases activating proteins) by being used as tools to inactivate specific membrane trafficking events. GAPs serve to increase GTPase activity by contributing the residues to the active site and promoting conversion from GTP to GDP form. Such activity of TBC proteins does not always require a close physical interaction although few TBC proteins have shown clear GAP activity towards their binding Rabs . Rab families contribute to defining organelles and controlling specificity and rate of transport through individual pathways. Therefore, TBC Rab-GAPS are essential regulators of intracellular and membrane transports as well as central participants in signal transduction . Nevertheless, not all TBC may have
288-878: The operator of three tram lines and a bus network in Bordeaux, France TBC Bank , a private bank in Republic of Georgia TBC Corporation , parent company of National Tire and Battery and other tire retailers and distributors The Beistle Company of Shippensburg, Pennsylvania, US The Boiling Crab , a Cajun restaurant chain The Boring Company of Elon Musk, in California, US Medicine [ edit ] Tuberculosis , lethal, infectious disease common before World War II Radio and television [ edit ] Tanzania Broadcasting Corporation , official Tanzanian broadcaster known as TBC Taegu Broadcasting Corporation ,
306-666: The operator of three tram lines and a bus network in Bordeaux, France TBC Bank , a private bank in Republic of Georgia TBC Corporation , parent company of National Tire and Battery and other tire retailers and distributors The Beistle Company of Shippensburg, Pennsylvania, US The Boiling Crab , a Cajun restaurant chain The Boring Company of Elon Musk, in California, US Medicine [ edit ] Tuberculosis , lethal, infectious disease common before World War II Radio and television [ edit ] Tanzania Broadcasting Corporation , official Tanzanian broadcaster known as TBC Taegu Broadcasting Corporation ,
324-514: The target Rabs of TBC by investigating their in vitro GAP activity. Yet there has been similar discrepancies between this findings of different investigators which can be found in literature and may be attributable to differences between methods of in vitro . In addition, research has shown that TBC proteins are associated with some human diseases . For example, a dysfunction of TBC1D1 and TBC1D4 directly affects insulin actions and glucose uptake. Causing overweight or leanness due to
#476523