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59-643: SGC research activities take place in a coordinated network of university-affiliated laboratories – at Goethe University Frankfurt , Karolinska Institutet , McGill University , and the Universities of North Carolina at Chapel Hill and Toronto . The research activities are supported both by funds from the SGC Company as well as by grants secured by the scientists affiliated with the SGC programs. At each university,

118-515: A Canadian charity Agora Open Science Trust whose mandate is to share scientific knowledge and ensure affordable access to all medicines. M4K Pharma has the most advanced open drug discovery program and is supported with funding from the Ontario Institute for Cancer Research , The Brain Tumour Charity , Charles River Laboratories and Reaction Biology, and with contributions from scientists at

177-430: A Structural Genomics Consortium to focus on determining the three-dimensional structures of human proteins. The consortium must place all structural information and supporting reagents into the public domain without restriction. This effort was designed to complement other structural genomics programs in the world. The SGC scientific program was launched, with activities at the Universities of Oxford and Toronto, and with

236-516: A mandate to contribute >350 human protein structures into the public domain. To be counted toward these goals, the proteins had to derive from a pre-defined list and the protein structures were required to meet pre-defined quality criteria. The quality of protein structures was and continues to be adjudicated by a committee of independent academic scientists. Michael Morgan was the Chair of the SGC Board, and

295-443: A partner organization that focuses on commercialization, FACIT. FACIT provides seed funding to Ontario-based cancer research companies and helps them attract other investors and bring products to market. It claims to have attracted $ 1.6 billion in investment from $ 50 million in funding. Notable investments includes Fusion Pharmaceuticals, which was purchased by AstraZeneca for up to $ 2.4 billion in 2024, and Turnstone Biologics, which

354-669: Is a public research university located in Frankfurt am Main , Germany . It was founded in 1914 as a citizens' university, which means it was founded and funded by the wealthy and active liberal citizenry of Frankfurt. The original name in German was Universität Frankfurt am Main . In 1932, the university's name was extended in honour of one of the most famous native sons of Frankfurt, the poet, philosopher and writer/dramatist Johann Wolfgang von Goethe . The university currently has around 48,000 students, distributed across four major campuses within

413-723: Is a key operating principle. A Trust Agreement is signed before reagents are shared with researchers. These reagents include cDNA clones ( Addgene ), chemical probes , and 3D structures . Tools to promote open science include o pen lab notebooks . The latter platform is being used to share research on (for example) Diffuse intrinsic pontine glioma (DIPG), Fibrodysplasia ossificans progressiva , Huntington’s disease , Parkinson’s disease , and Chordoma . The for-profit spin-off companies M4K Pharma (Medicines for Kids), M4ND Pharma (Medicines for Neurological Diseases) and M4ID Pharma (Medicines for Infectious Diseases) do not file patents and practise open science. The M4 companies are wholly owned by

472-895: Is also the university's official support association. Local, regional, national, European and international student initiatives have given rise to many parallel alumni networks that run in parallel and independently of each other. These include the alumni organisations of AIESEC , MTP - Marketing between Theory and Practice, European Law Students' Association , Erasmus Student Network and others. Student initiatives such as green finance consulting, Goethe Club, Goethe Gruppe or Night of Science, as well as political university groups, are further hybrids between student initiatives and alumni organisations. Independent alumni organisations are not recognised as official alumni organisations at Goethe University. According to

531-966: Is funded by the Ontario Ministry of Colleges and Universities. OICR hosts a number of cancer research resources, including the Ontario Cancer Research Ethics Board (OCREB); the Ontario Tumor Bank (OTB); the Ontario Health Study, the Ontario arm of the CanPath longitudinal study - the largest such study in Canada; and the Canadian Cancer Clinical Trials Network (CCTG). As part of its mandate to bring economic benefit to Ontario through cancer research, OICR has

590-457: Is open to the public and welcomes visitors with a spacious, naturally lit foyer that leads to lecture halls, seminar rooms, and the information center, a 24-hour reference library. The ground floor also accommodates computer rooms and a café. The floors, walls and ceiling of the foyer are decorated with a grid design that is continued throughout the entire building. The flooring is inspired by Raphael's mural, The School of Athens . The emergence of

649-677: Is part of the IT cluster Rhine-Main-Neckar . The Johannes Gutenberg University Mainz , the Goethe University Frankfurt and the Technische Universität Darmstadt together form the Rhine-Main-Universities (RMU). The historical roots of the university can be traced back as far as 1484, when a City Council Library was established with a bequest from the patrician Ludwig von Marburg. Merged with other collections, it

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708-405: Is supported by publicly available bioinformatics tools (ChromoHub, UbiHub), family-based protein production and biochemistry, crystallography and structure determination, biophysics, and cell biology (for example target engagement assays). The SGC has (so far) contributed ~120 chemical probes into the public domain over the past decade, and >25,000 samples of these probes have been distributed to

767-695: Is the Frankfurter Wirtschaftswissenschaftliche Gesellschaft (fwwg), which was founded in 1988 and is open to the Department of Economics. The Association of Friends and Supporters of the Johann Wolfgang Goethe University Frankfurt am Main ( Vereinigung von Freunden und Förderern der Johann Wolfgang Goethe-Universität Frankfurt am Main ) acts unofficially as an umbrella organisation for the university-related alumni organisations at Goethe University and

826-603: Is why there is hardly any transparency about university policy. There are official publications on the Goethe University website, which must be made in accordance with the Hessian Higher Education Act. These can also be found in the German National Library . Little can be said about the political significance of university politics due to the lack of transparency in university politics as a whole and

885-637: The Bill & Melinda Gates Foundation . The University of North Carolina at Chapel Hill and the Eshelman Institute for Innovation, launched Rapidly Emerging Antiviral Drug Development Initiative (READDI™) and Viral Interruption to Medicines Initiative (VIMI™). REDDI™ is modelled after the non-profit drug research and development Drugs for Neglected Diseases Initiative (DNDi). READDI™ and VIMI™ are non-profit, open science initiatives that focus on developing therapeutics for all pandemic-capable viruses. Open science

944-655: The Goethe Business School offers an MBA program. Goethe University has established an international award for research in financial economics, the Deutsche Bank Prize in Financial Economics . The university consists of 16 faculties. Ordered by their sorting number, these are: In addition, there are several co-located research institutes of the Max Planck Society : The university is involved in

1003-670: The Hessian Center for Artificial Intelligence  [ de ] (hessian.AI). The university is located across four campuses in Frankfurt am Main: The Westend Campus is the main location with the Presidential Board based in the Presidential and Administration Building (PA). The campus includes the I. G. Farben Building and numerous new buildings, including the House of Finance and

1062-667: The MaRS Centre in downtown Toronto and funds more than 1,900 scientific staff at hospital-based research institutes and universities around the province. In 2018 it was the highest funder of cancer research in Canada. OICR’s predecessor organization was the Ontario Cancer Research Network (OCRN), a not-for-profit corporation established by the Government of Ontario in November 2001 to increase translational research related to

1121-523: The Nazi period, "almost one third of its academics and many of its students were dismissed for racial and/or political reasons—more than at any other German university" . The university also played a major part in the German student movement of 1968. The university also has been influential in the natural sciences and medicine, with Nobel Prize winners including Max von Laue and Max Born , and breakthroughs such as

1180-568: The QS World University Rankings for 2024, the university holds a global position of 302 and ranks 18th nationally. In the 2024 edition of the Times Higher Education World University Rankings , it is positioned between 201 and 250 internationally, and 22 to 24 within the country. The university achieved its highest national ranking in the 2023 Academic Ranking of World Universities (ARWU), where it

1239-639: The Stern–Gerlach experiment . In recent years, the university has focused in particular on law, history, and economics, creating new institutes, such as the Institute for Law and Finance (ILF) and the Center for Financial Studies (CFS) . One of the university's ambitions is to become Germany's leading university for finance and economics, given the school's proximity to one of Europe's financial centers. In cooperation with Duke University 's Fuqua School of Business ,

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1298-598: The public domain since 2003. Structures that constitute complexes with synthetic small molecules is aided by a partnership with the Diamond synchrotron in Oxfordshire . The chemical probe program prioritizes (members of) protein families that are relatively understudied, or which may be currently relevant to human biology and drug discovery. These families include epigenetic signaling , solute transport , protein proteostasis, and protein phosphorylation . The protein family approach

1357-628: The Bockenheim district have been abandoned and partly demolished, partly put to other uses. The Goethe Business School is a graduate business school at the university, established in 2004, part of the House of Finance at the Westend Campus and the IKB building. It is a non-profit foundation under private law held by the university. Its board of directors is led by Rolf-Ernst Breuer , who was chairman of

1416-534: The Canadian Institutes for Health Research left the consortium. Markus Gruetter became the Chair of the SGC Board. This phase built on the goals of previous phases but included well-characterized antibodies to human proteins. The SGC initiated a concerted effort to develop disease-relevant, cell-based assays using (primary) cells or tissue from patients. This phase saw the launch of research activities at Goethe University in Frankfurt, at McGill University, and at

1475-404: The Department of Medicine, with buildings and facilities that have grown historically since the 19th century as well as modern complexes. Sports. The university's relocation programme, which has been intensified since the mid-1990s, aims to create a de facto three-campus university in the future. To this end, the units currently located in the Bockenheim district are also to be relocated, but not

1534-470: The Deutschlandstipendium programme. These initiatives are supported by the non-material support programme for the Deutschlandstipendium from the Presidential Board of Goethe University. Goethe University has its own non-exhaustive network of alumni organisations, a sponsors' association and its own e-mail distribution list for alumni. Alumni organisations require formal recognition and approval by

1593-627: The Federal Republic of Germany and the Basic Law ( Grundgesetz ) can be traced back to the Frankfurter Dokumente that were handed over in the I. G. Farben Building . The Bockenheim campus is the former centre of the university, which still houses various parts of the language and cultural sciences, the Department of Computer Science and Mathematics, the central building of the university library Johann Christian Senckenberg and some parts of

1652-556: The Ontario cancer research community and external experts to develop a strategic research plan for the Institute in 2006. In February 2007 the completed strategic plan was approved by the Ministry of Research and Innovation. Laszlo Radvanyi was appointed President and Scientific Director of OICR in May 2018. The current strategic plan is updated to reflect patient partnership as a priority. OICR

1711-772: The SGC’s epigenetics chemical probe program, the NIH’s Illuminating the Druggable Genome initiative for under-explored kinases, GPCR’s and ion channels, IMI’s RESOLUTE project on human SLCs, and IMI's Enabling and Unlocking Biology in the Open ( EUbOPEN ). These teams are linked to SGC’s global collaborative network. Goethe University Frankfurt Goethe University Frankfurt (German: Johann Wolfgang Goethe-Universität Frankfurt am Main )

1770-709: The Universities of Campinas and North Carolina, and participation in ULTRADD and RESOLUTE within IMI . SGC Memberships: Merck KGaA, the Eshelman Institute for Innovation, Merck, Sharpe and Dohme joined while GSK and Eli Lilly left. Tetsuyuki Maruyama became the Chair of the Board. Target 2035 is an open science movement with the goal of creating chemical and/or biological tools for the entire proteome by 2035. The launch in November 2020 and monthly webinars have and continue to be free to attend . Supporting projects currently underway include

1829-581: The Universities of McGill, North Carolina, Oxford, Pennsylvania, and Toronto and in the Sant Joan de Déu hospital, the University Health Network hospitals, the Hospital for Sick Children , and The Institute for Cancer Research . M4K Pharma is developing a selective inhibitor of ALK2 for DIPG , a uniformly fatal pediatric brain tumour. In 2000, a group of companies and Wellcome conceptualized forming

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1888-493: The University of Frankfurt include the sociologist Karl Mannheim , the philosopher Hans-Georg Gadamer , the philosophers of religion Franz Rosenzweig , Martin Buber , and Paul Tillich , the psychologist Max Wertheimer , and the sociologist Norbert Elias . The University of Frankfurt has at times been considered liberal, or left-leaning, and has had a reputation for Jewish and Marxist (or even Jewish-Marxist) scholarship . During

1947-590: The administration in buildings dating from the 1950s to the 1970s. The Riedberg campus, with university buildings built from around 1970, is home to the Departments of Physics, Biochemistry, Chemistry and Pharmacy, Biosciences and (largely) Earth Sciences, the Science Garden and a lecture theatre centre with the natural sciences departmental library. The Niederrad campus is home to the University Hospital and

2006-551: The board of Deutsche Bank until 2006. The school has maintained a partnership in Executive Education with the Indian School of Business (ISB) since 2009. The word/image mark used from 1980 to 2002 was developed by Adrian Frutiger . There are different types of basically the same logo. As old university logos never really "expire", they remain valid. Since 2008, the university administration has made various changes to

2065-438: The central lecture theatre building. In addition to the central administration, most departments, with the exception of Medicine and Natural Sciences, are or have been located here since 2001. The Language and Art Building (SKW) (FB 09) is currently the new building on campus. This campus is of particular historical significance, as Goethe University has inherited history through the acquisition of real estate. "Campus Westend" of

2124-604: The chemical probes’ programs were undertaken in partnership with scientists in the pharmaceutical companies, which made the commitment to contribute the collaborative chemical probe into the public domain, without restriction. In Phase III, the SGC, along with the SSGCID (https://www.ssgcid.org/) and the CSGID (https://csgid.org/) launched the SDDC. SGC Memberships: AbbVie, Bayer AG, Boehringer Ingelheim, Eli Lilly and Janssen. Merck, Sharpe and Dohme and

2183-507: The city. The university celebrated its 100th anniversary in 2014. The first female president of the university, Birgitta Wolff , was sworn into office in 2015, and was succeeded by Enrico Schleiff in 2021. 20 Nobel Prize winners have been affiliated with the university, including Max von Laue and Max Born . The university is also affiliated with 18 winners of the Gottfried Wilhelm Leibniz Prize . Goethe University

2242-525: The development of new cancer therapies. OCRN’s four main program areas were: the Ontario Tumour Bank, Clinical Trials Programs, the Ontario Cancer Research Ethics Board and the Cancer Research Fund. The organization was headed by Robert A. Phillips. In May 2005 the Government of Ontario announced its intent to launch a new cancer research institute in the province. OCRN was asked to evolve into

2301-490: The fields of finance and money and macroeconomics, and whose work has led to practical and policy-relevant results. It is awarded biannually, since 2005, by the Center for Financial Studies , in partnership with Goethe University Frankfurt. The award carries an endowment of €50,000, which is donated by the Stiftungsfonds Deutsche Bank im Stifterverband für die Deutsche Wissenschaft. According to information from

2360-561: The foundation capital of the University of Frankfurt. The university has been best known historically for its Institute for Social Research (founded 1924), the institutional home of the Frankfurt School , a preeminent 20th-century school of philosophy and social thought. Some of the well-known scholars associated with this school include Theodor Adorno , Max Horkheimer , and Jürgen Habermas , as well as Herbert Marcuse , Erich Fromm , and Walter Benjamin . Other well-known scholars at

2419-616: The foundation contract for the "Königliche Universität zu Frankfurt am Main" (Royal University at Frankfurt on the Main) was signed at the Römer, Frankfurt's town hall. Royal permission for the university was granted on 10 June 1914, and the first enrollment of students began on 16 October 1914. Members of Frankfurt's Jewish community, including the Speyer family , Wilhelm Ralph Merton , and the industrialists Leo Gans and Arthur von Weinberg donated two thirds of

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2478-451: The lack of interest in its activities. Students are not very interested in university politics due to a voter turnout of less than 15% in recent years and the incidents and judgements against the AStA. The university management and the departments support numerous private and university-affiliated student groups, initiatives and private alumni organisations. There are also networks between

2537-521: The new institute, which would later be named OICR. OICR was formally launched by Ontario Premier Dalton McGuinty in December 2005. OICR was designed to continue OCRN’s translational research programs while building new research capacity in the province. Thomas J. Hudson was appointed President and Scientific Director of OICR in June 2006 and Robert A. Phillips was appointed Deputy Director. Hudson consulted with

2596-470: The practical name of the university and, accordingly, to the logo. On 26 September 2016, another logo was also registered at the German Patent and Trade Mark Office as an individual trade mark, consisting only of the words "GOETHE UNIVERSITY". However, this logo is not currently in use. The Deutsche Bank Prize in Financial Economics honors renowned researchers who have made influential contributions to

2655-563: The prevention, early detection, diagnosis and treatment of cancer . OICR intends to make Ontario more effective in knowledge transfer and commercialization while maximizing the health and economic benefits of research findings for the people of Ontario. OICR was launched in 2005 by the Government of Ontario , which provides funding through the Ministry of Colleges and Universities . The Institute employs more than 300 people at its research hub at

2714-406: The public domain. A pilot program in the structural biology of proteins in the malaria parasite was also initiated. The new goal for structures was 650. The SGC focused considerable activities in the areas of ubiquitination, protein phosphorylation, small G-proteins and epigenetics, and also initiated an effort in the structural biology of integral membrane proteins. In this phase, the SGC determined

2773-461: The scientific activities were led by Cheryl Arrowsmith (Toronto) and Michael Sundstrom (Oxford). In mid 2005, VINNOVA , the Knut and Alice Wallenberg Foundation and the Foundation for Strategic Research (SSF) established the Swedish research node of the SGC. Experimental activities started at the Karolinska Institutet in Stockholm, led by Pär Nordlund and Johan Weigelt. Together, the three SGC laboratories contributed 392 human protein structures into

2832-610: The scientific community. The chemical probes conform to the now community-standard quality criteria created by the SGC and its collaborative network. The Structure-guided Drug Discovery Coalition (SDDC) comprises the Seattle Structural Genomics Center for Infectious Disease (SSGCID), the Midwest Center for Structural Genomics, the Center for Structural Genomics of Infectious Diseases (CSGID), and drug discovery teams from academia and industry has resulted in 7 early drug leads for tuberculosis (TB), malaria, and cryptosporidiosis. The SDDC receives funding from participating academic initiatives and

2891-505: The scientific teams are led by a Chief Scientist, who are Stefan Knapp (Goethe University Frankfurt), Michael Sundstrom (Karolinska Institutet), Ted Fon (McGill University), Tim Willson (University of North Carolina at Chapel Hill), and Cheryl Arrowsmith (University of Toronto). The SGC currently comprises ~200 scientists. Structural biology of human proteins – The SGC has so far contributed over 2000 protein structures of human proteins of potential relevance for drug discovery into

2950-528: The sports grounds. The public Botanical Garden Frankfurt am Main at the end of Siesmayerstraße, formerly associated with the biology campus (1956-2011), has been transferred to the City of Frankfurt am Main and the responsibility of the Palmengarten . Parts of the former Bockenheim campus, including the historic Jügelhaus, have been taken over by the Senckenberg Gesellschaft für Naturforschung , while other parts have been left to local urban development. The formerly numerous other scattered university buildings in

3009-496: The structures of 665 human proteins from its Target List. With support from Wellcome and GSK, the SGC launched a program to develop freely-available chemical probes to proteins involved in epigenetic signalling which at the time were under studied. The quality of each chemical probe was subject to two levels of review prior to their dissemination to the public. The first was internal, through a Joint Management Committee comprising representatives from each member organization. The second

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3068-432: The student university groups and initiatives via the departments and the Goethe University Network: The student councils at Goethe University are legally regulated by the Hessian Higher Education Act. They are therefore not student initiatives in the traditional sense, as they are legally binding institutions without their own legal personality. New student initiatives are regularly created at Goethe University as part of

3127-431: The university administration in order to be listed as official alumni associations. Without such recognition, it is not possible for the association to list itself as an official alumni organisation of Goethe University. Officers of these organisations are mostly current and former professors as well as people in leading positions at Goethe University. The largest university-related alumni organisation with over 1,300 members

3186-426: The university is dominated by the IG Farben Building by architect Hans Poelzig, an example of the modernist New Objectivity style. The style for the IG Farben Building was originally chosen as "a symbol for the scientific and mercantile German manpower, made out of iron and stone", as the IG Farben director at the time of construction, Baron von Schnitzler , stated in his opening speech in October 1930. After

3245-408: The university took over the complex in the 1990s, new buildings were added to the campus. On 30 May 2008, the House of Finance relocated to a new building designed by the architects Kleihues+Kleihues, following the style of the IG Farben Building. The upper floors of the House of Finance building have several separate offices as well as shared office space for researchers and students. The ground floor

3304-539: The university, the political university groups are as follows: There is little public information on the individual university groups and the work of the university committees, as there is usually only up-to-date information on university politics and/or university political actors on the respective websites of the General Students' Committee and the respective university parties, as well as representations in social networks. Further information and archives on university policy work at Goethe University do not exist, which

3363-422: Was placed between 151 and 200 globally, and 6 to 9 nationally. The New York Times : Among the World's 10 best universities by employer choice. Goethe University was ranked 10 out of 150 universities in 2012. Ontario Institute for Cancer Research The Ontario Institute for Cancer Research ( OICR ) is a not-for-profit organization based in Toronto , Ontario , Canada that focuses on research into

3422-499: Was provided by a group of independent experts selected from academia. This level of oversight is aimed at developing reagents that support reproducible research. It ultimately led to the creation of the Chemical Probes Portal . The SGC Memberships expanded to include Merck, Sharpe and Dohme, and Novartis. Wayne Hendrickson served as the Chair of the SGC Board. The SGC mandate diversified to include 200 human proteins including 5 integral membrane proteins and chemical probes (30). Many of

3481-458: Was renamed City Library in 1668 and became the university library in 1914. Depending on the country, the date of foundation is recorded differently. According to Anglo-American calculations, the founding date of Goethe University would be 1484. In Germany, the date on which the right to award doctorates is granted is considered the founding year of a university. The modern history of the University of Frankfurt can be dated to 28 September 1912, when

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