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70-739: The Northern Paiute people are a Numic people that has traditionally lived in the Great Basin region of the United States in what is now eastern California , western Nevada , and southeast Oregon . The Northern Paiute pre-contact lifestyle was well adapted to the harsh desert environment in which they lived. Each tribe or band occupied a specific territory, generally centered on a lake or wetland that supplied fish and waterfowl. Communal hunt drives, which often involved neighboring bands, would take rabbits and pronghorn from surrounding areas. Individuals and families appear to have moved freely among

140-405: A bone marrow transplant , in which (undifferentiated) hematopoietic stem cells are transferred. When B cells and T cells are activated by a pathogen, memory B-cells and T- cells develop, and the primary immune response results. Throughout the lifetime of an animal, these memory cells will "remember" each specific pathogen encountered, and can mount a strong secondary response if the pathogen

210-418: A pathogen or toxin are transferred to non- immune individuals. Passive immunization is used when there is a high risk of infection and insufficient time for the body to develop its own immune response, or to reduce the symptoms of ongoing or immunosuppressive diseases. Passive immunity provides immediate protection, but the body does not develop memory, therefore the patient is at risk of being infected by

280-401: A vaccine , a substance that contains antigen. A vaccine stimulates a primary response against the antigen without causing symptoms of the disease. The term vaccination was coined by Richard Dunning, a colleague of Edward Jenner , and adapted by Louis Pasteur for his pioneering work in vaccination. The method Pasteur used entailed treating the infectious agents for those diseases, so they lost

350-404: A century to treat infectious disease, and before the advent of antibiotics , was often the only specific treatment for certain infections. Immunoglobulin therapy continued to be a first line therapy in the treatment of severe respiratory diseases until the 1930s, even after sulfonamide lot antibiotics were introduced. Passive or " adoptive transfer " of cell-mediated immunity, is conferred by

420-570: A distinct linguistic variety, there are no unique linguistic changes that mark Mono as a distinct linguistic variety. The sound system of Numic is set forth in the following tables. Proto-Numic had an inventory of five vowels. Proto-Numic had the following consonant inventory: In addition to the above simple consonants, Proto-Numic also had nasal-stop/affricate clusters and all consonants except *s , *h , *j , and *w could be geminated. Between vowels short consonants were lenited. The major difference between Proto-Central Numic and Proto-Numic

490-468: A figure in the eyes of the public by making claims of being a princess and using this attention to advocate for her people. Shamanism is popular among most Native American tribes, including the Northern Paiute people. A shaman is a medicine man called a puhagim by Northern Paiute people. The Northern Paiute believe in a force called puha that gives life to the physical world. It is the power that moves

560-475: A fire and cared for it until the fire grew bigger and bigger. The water from the flood dried, and a man "happened." This man was called Nűműzóho, who was a cannibal. The Cannibals (as he and his kind were called) killed all the Native people, except for a woman who was able to escape. This woman kept herself alive by traveling from place to place in the region, meeting and staying with different characters. She then found

630-586: A fire. The season for story-telling in the American West was during the winter months. The elderly members of the tribe would animatedly and humorously tell the tale from their memory as told to them by previous elders and family members. They were told “as a way to pass on tribal visions of the animal people and the human people, their origins and values, their spiritual and natural environment, and their culture and daily lives.” The stories were often poems that were performed musically, called "song-poems." Members of

700-399: A full theory of immunity was Ilya Mechnikov who revealed phagocytosis in 1882. With Louis Pasteur 's germ theory of disease , the fledgling science of immunology began to explain how bacteria caused disease, and how, following infection, the human body gained the ability to resist further infections. In 1888 Emile Roux and Alexandre Yersin isolated diphtheria toxin , and following

770-454: A man living in the mountains whom she married. They bore four children: two Paiute (one brother, one sister) and two Pit Rivers (one brother, one sister). The two sets of children fought frequently because they were from different tribes. Their father (some think he was a Wolf) threw them in different waters. This caused them to go their separate ways while continuing to fight and quarrel whenever they came in contact with each other again. And thus

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840-479: Is acquired through the exposure to a pathogen, which triggers the production of antibodies by the immune system. Passive immunity is acquired through the transfer of antibodies or activated T-cells derived from an immune host either artificially or through the placenta; it is short-lived, requiring booster doses for continued immunity. The diagram below summarizes these divisions of immunity. Adaptive immunity recognizes more diverse patterns. Unlike innate immunity it

910-473: Is also found in the epic poem " Pharsalia " written around 60 BC by the poet Marcus Annaeus Lucanus to describe a North African tribe's resistance to snake venom . The first clinical description of immunity which arose from a specific disease-causing organism is probably A Treatise on Smallpox and Measles ("Kitab fi al-jadari wa-al-hasbah″, translated 1848 ) written by the Islamic physician Al-Razi in

980-571: Is also provided through the transfer of IgA antibodies found in breast milk that are transferred to the gut of a nursing infant, protecting against bacterial infections, until the newborn can synthesize its antibodies. Colostrum present in mothers milk is an example of passive immunity. Artificially acquired passive immunity is a short-term immunization induced by the transfer of antibodies, which can be administered in several forms; as human or animal blood plasma, as pooled human immunoglobulin for intravenous ( IVIG ) or intramuscular (IG) use, and in

1050-463: Is also said to have sought to create a 'universal antidote' to protect him from all poisons. For nearly 2000 years, poisons were thought to be the proximate cause of disease, and a complicated mixture of ingredients, called Mithridate , was used to cure poisoning during the Renaissance . An updated version of this cure, Theriacum Andromachi , was used well into the 19th century. The term "immunes"

1120-413: Is associated with memory of the pathogen. For thousands of years mankind has been intrigued with the causes of disease and the concept of immunity. The prehistoric view was that disease was caused by supernatural forces, and that illness was a form of theurgic punishment for "bad deeds" or "evil thoughts" visited upon the soul by the gods or by one's enemies. In Classical Greek times, Hippocrates , who

1190-414: Is defined as the first line of defense against pathogens, representing a critical systemic response to prevent infection and maintain homeostasis, contributing to the activation of an adaptive immune response. It does not adapt to specific external stimulus or a prior infection, but relies on genetically encoded recognition of particular patterns. Adaptive or acquired immunity is the active component of

1260-419: Is detected again. The primary and secondary responses were first described in 1921 by English immunologist Alexander Glenny although the mechanism involved was not discovered until later. This type of immunity is both active and adaptive because the body's immune system prepares itself for future challenges. Active immunity often involves both the cell-mediated and humoral aspects of immunity as well as input from

1330-437: Is present in all metazoans , immune responses: inflammatory responses and phagocytosis . The adaptive component, on the other hand, involves more advanced lymphatic cells that can distinguish between specific "non-self" substances in the presence of "self". The reaction to foreign substances is etymologically described as inflammation while the non-reaction to self substances is described as immunity. The two components of

1400-546: Is regarded as the Father of Medicine, diseases were attributed to an alteration or imbalance in one of the four humors (blood, phlegm, yellow bile or black bile). The first written descriptions of the concept of immunity may have been made by the Athenian Thucydides who, in 430 BC, described that when the plague hit Athens : "the sick and the dying were tended by the pitying care of those who had recovered, because they knew

1470-555: Is required for defense of tuberculosis in humans. Individuals with genetic defects in TNF may get recurrent and life-threatening infections with tuberculosis bacteria ( Mycobacterium tuberculosis ) but are otherwise healthy. They also seem to respond to other infections more or less normally. The condition is therefore called Mendelian susceptibility to mycobacterial disease (MSMD) and variants of it can be caused by other genes related to interferon production or signaling (e.g. by mutations in

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1540-431: Is thought to have assumed that those animals acquired some detoxifying property, so that their blood would contain transformed components of the snake venom that could induce resistance to it instead of exerting a toxic effect. Mithridates reasoned that, by drinking the blood of these animals, he could acquire a similar resistance. Fearing assassination by poison, he took daily sub-lethal doses of venom to build tolerance. He

1610-635: Is unknown, but, about 1000 AD, the Chinese began practicing a form of immunization by drying and inhaling powders derived from the crusts of smallpox lesions. Around the 15th century in India , the Ottoman Empire , and east Africa , the practice of inoculation (poking the skin with powdered material derived from smallpox crusts) was quite common. This practice was first introduced into the west in 1721 by Lady Mary Wortley Montagu [the phrase "first introduced into

1680-542: The Centers for Disease Control and Prevention (CDC) concluded that "Multiple studies in different settings have consistently shown that infection with SARS-CoV-2 and vaccination each result in a low risk of subsequent infection with antigenically similar variants for at least 6 months. Numerous immunologic studies and a growing number of epidemiologic studies have shown that vaccinating previously infected individuals significantly enhances their immune response and effectively reduces

1750-635: The Indian Reorganization Act of 1934, several individual colonies gained federal recognition as independent tribes . Humans have inhabited the area between the West and Northwest of the United States for over 11,000 years. One version of how the Northern Paiute people came to be is that a bird, the Sagehen (also known as the Centrocercus ), was the only bird that survived a massive flood. The Sagehen made

1820-559: The Pyramid Lake War of 1860, Owens Valley Indian War 1861–1864, Snake War 1864–1868; and the Bannock War of 1878. These incidents generally began with a disagreement between settlers and the Paiute (singly or in a group) regarding property, retaliation by one group against the other, and finally counter-retaliation by the opposite party, frequently culminating in the armed involvement of

1890-450: The Reno area, Washoe people. Later, the government created larger reservations at Pyramid Lake and Duck Valley , Nevada . By that time the pattern of small de facto reservations near cities or farm districts, often with mixed Northern Paiute and Shoshone populations, had been established. Starting in the early 20th century, the federal government began granting land to these colonies. Under

1960-613: The U.S. Army . Fatalities were much higher among the Paiute due to newly introduced Eurasian infectious diseases , such as smallpox , which were endemic among the Europeans. The Natives had no acquired immunity . Sarah Winnemucca 's book Life Among the Piutes (1883) gives a first-hand account of this period. The US government first established the Malheur Reservation for the Northern Paiute in eastern Oregon. It intended to concentrate

2030-461: The innate immune system . Naturally acquired active immunity occurs as the result of an infection. When a person is exposed to a live pathogen and develops a primary immune response , this leads to immunological memory. Many disorders of immune system function can affect the formation of active immunity, such as immunodeficiency (both acquired and congenital forms) and immunosuppression . Artificially acquired active immunity can be induced by

2100-454: The 1770 population of the Northern Paiute within California was 500. He estimated their population in 1910 as 300. Others put the total Northern Paiute population in 1859 at about 6,000. Numic languages These languages are classified in three groups: Apart from Comanche , each of these groups contains one language spoken in a small area in the southern Sierra Nevada and valleys to

2170-412: The 1890 discovery by Behring and Kitasato of antitoxin based immunity to diphtheria and tetanus , the antitoxin became the first major success of modern therapeutic immunology. In Europe , the induction of active immunity emerged in an attempt to contain smallpox . Immunization has existed in various forms for at least a thousand years, without the terminology. The earliest use of immunization

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2240-435: The 20th century, gender roles began to shift. Men worked in seasonal jobs and the women mainly worked in laundry and medicine. The shift happened because the men that worked seasonal jobs would not have work at the end of a given season, while women had consistent work. This made women a major provider in the family. Another shift came in the shape of politics. While some women disrupted tribe meetings, Sarah Winnemucca became

2310-491: The 9th century. In the treatise, Al Razi describes the clinical presentation of smallpox and measles and goes on to indicate that exposure to these specific agents confers lasting immunity (although he does not use this term). Until the 19th century, the miasma theory was also widely accepted. The theory viewed diseases such as cholera or the Black Plague as being caused by a miasma, a noxious form of "bad air". If someone

2380-575: The Cannibal who kills almost all of the Indians but not the woman; Coyote is "the one who fixed things," mentioned briefly in many of the origin stories; a man and a woman who meet and bear four children; the four children who are paired off into different tribes and quarrel with the other pair. The creativity in which the stories were told is part of the reason for such an array of versions. These epic stories were first told long ago to large groups gathered around

2450-938: The Central and Western Numic languages expanded into the Great Basin. Bands of eastern Shoshoni split off from the main Shoshoni body in the very late 17th or very early 18th century and moved southeastward onto the Great Plains. Changes in their Shoshoni dialect eventually produced Comanche. The Comanche language and the Shoshoni language are quite similar although certain low-level consonant changes in Comanche have inhibited mutual intelligibility. Recent lexical and grammatical diffusion studies in Western Numic have shown that while there are clear linguistic changes that separate Northern Paiute as

2520-682: The Nevada/California area in which they currently reside. They also may have overthrown and destroyed other Indian tribes in order to inhabit their current lands. For example, the Paiute were almost "continually at war" with the Klamath south and west of them. "The Achomawi, south of the Klamath, also were enemies of the Northern Paiute, (so much so that) the earliest wars related in Achomawi oral tradition were (with) Northern Paiute". Sustained contact between

2590-443: The Northern Paiute and European Americans began in the early 1840s, although the first contact may have occurred as early as the 1820s. Although the Paiute had adopted the use of horses from other Great Plains tribes, their culture was otherwise then largely unaffected by European influences. As Euro-American settlement of the area progressed, competition for scarce resources increased. Several violent confrontations took place, including

2660-440: The Northern Paiute community. The Northern Paiute believe that doctors/shaman retrieve the souls of those who have committed wrongdoings and re-establish them in to Native American society. They are the intermediaries between the evil acts of the sick and the goodness of the healthy tribe. For this reason, Northern Paiute do not perceive white doctors as capable of fully healing those in need because although they may be able to cure

2730-546: The Northern Paiute there, but its strategy did not work. Because of the distance of the reservation from the traditional areas of most of the bands, and because of its poor environmental conditions, many Northern Paiute refused to go there. Those that did, soon left. They clung to their traditional lifestyle as long as possible. When environmental degradation of their lands made that impossible, they sought jobs on white farms, ranches or in cities. They established small Indian colonies , where they were joined by many Shoshone and, in

2800-450: The Paiute were created and their homes established in Nevada, California, and Oregon. Another version of the creation story tells of a man and a woman who heard a voice from within a bottle. They dumped the contents of the bottle out, and four beings dropped out: two boys and two girls. The 4 people were divided by good and evil. The two good people (Paiute) were to be protected and cared for by

2870-708: The ability to cause serious disease. Pasteur adopted the name vaccine as a generic term in honor of Jenner's discovery, which Pasteur's work built upon. In 1807, Bavaria became the first group to require their military recruits to be vaccinated against smallpox, as the spread of smallpox was linked to combat. Subsequently, the practice of vaccination would increase with the spread of war. There are four types of traditional vaccines : In addition, there are some newer types of vaccines in use: A variety of vaccine types are under development; see Experimental Vaccine Types . Most vaccines are given by hypodermic or intramuscular injection as they are not absorbed reliably through

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2940-581: The above changes. Forms in the daughter languages are written in a broad phonetic transcription rather than a phonemic transcription that sometimes masks the differences between the forms. Italicized vowels and sonorants are voiceless. Immunity (medical) In biology , immunity is the state of being insusceptible or resistant to a noxious agent or process, especially a pathogen or infectious disease . Immunity may occur naturally or be produced by prior exposure or immunization . The immune system has innate and adaptive components. Innate immunity

3010-401: The bands. Northern Paiute originally lived a seminomadic lifestyle, moving from place to place following animal migration patterns and seasonal foods. They lived in small, independent groups that consisted of a handful or so of different family units. Upon arrival of foreigners into western Nevada, the Northern Paiute became sedentary in order to protect themselves and handle negotiations with

3080-654: The clusters. Geminated stops and affricates are voiceless and non-geminated stops and affricates are voiced fricatives. The velar nasals have fallen together with the alveolar nasals. The dialects of Colorado River east of Chemehuevi have lost *h . The dialects east of Kaibab have collapsed the nasal-stop clusters with the geminated stops and affricate. Proto-Western Numic changed the nasal-stop clusters of Proto-Numic into voiced geminate stops. In Mono and all dialects of Northern Paiute except Southern Nevada, these voiced geminate stops have become voiceless. The following table shows some sample Numic cognate sets that illustrate

3150-413: The course of the disease and were themselves free from apprehensions. For no one was ever attacked a second time, or not with a fatal result". Active immunotherapy may have begun with Mithridates VI of Pontus (120-63 BC) who, to induce active immunity for snake venom, recommended using a method similar to modern toxoid serum therapy , by drinking the blood of animals which fed on venomous snakes. He

3220-459: The earliest record of Comanche from 1786, but precedes the 20th century. Geminated stops in Comanche have also become phonetically preaspirated. Proto-Southern Numic preserved the Proto-Numic consonant system fairly intact, but the individual languages have undergone several changes. Modern Kawaiisu has reanalyzed the nasal-stop clusters as voiced stops, although older recordings preserve some of

3290-533: The east (Mono, Timbisha, and Kawaiisu), and one language spoken in a much larger area extending to the north and east (Northern Paiute, Shoshoni, and Colorado River). Some linguists have taken this pattern as an indication that Numic speaking peoples expanded quite recently from a small core, perhaps near the Owens Valley , into their current range. This view is supported by lexicostatistical studies. Fowler's reconstruction of Proto-Numic ethnobiology also points to

3360-420: The elements, plants, and animals that are a part of that physical realm. Humans are seen to be very much a part of that world, not superior or inferior, simply another component. The Northern Paiute people believe that "matter and places are pregnant in form, meaning, and relations to natural and human phenomena." This belief gave credibility and placed necessity in shamans, as it does today. In order to draw upon

3430-448: The face of some opposition. However, inoculation had been reported in Wales since the early 17th century"]. In 1798, Edward Jenner introduced the far safer method of deliberate infection with cowpox virus, ( smallpox vaccine ), which caused a mild infection that also induced immunity to smallpox. By 1800, the procedure was referred to as vaccination . To avoid confusion, smallpox inoculation

3500-559: The form of monoclonal antibodies (MAb). Passive transfer is used prophylactically in the case of immunodeficiency diseases, such as hypogammaglobulinemia . It is also used in the treatment of several types of acute infection, and to treat poisoning . Immunity derived from passive immunization lasts for only a short period of time, and there is also a potential risk for hypersensitivity reactions, and serum sickness , especially from gamma globulin of non-human origin. The artificial induction of passive immunity has been used for over

3570-473: The gut. Live attenuated polio and some typhoid and cholera vaccines are given orally in order to produce immunity based in the bowel . Hybrid immunity is the combination of natural immunity and artificial immunity. Studies of hybrid-immune people found that their blood was better able to neutralize the Beta and other variants of SARS-CoV-2 than never-infected, vaccinated people. Moreover, on 29 October 2021,

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3640-567: The host immune response, mediated by antigen-specific lymphocytes . Unlike the innate immunity, the acquired immunity is highly specific to a particular pathogen, including the development of immunological memory . Like the innate system, the acquired system includes both humoral immunity components and cell-mediated immunity components. Adaptive immunity can be acquired either 'naturally' (by infection) or 'artificially' (through deliberate actions such as vaccination). Adaptive immunity can also be classified as 'active' or 'passive'. Active immunity

3710-423: The immune system create a dynamic biological environment where "health" can be seen as a physical state where the self is immunologically spared, and what is foreign is inflammatorily and immunologically eliminated. "Disease" can arise when what is foreign cannot be eliminated or what is self is not spared. Innate immunity, also known as native immunity, is a semi-specific and widely distributed form of immunity. It

3780-592: The mountains in the fall as a critical winter food source. Women also gathered grass seeds and roots as important parts of their diet. The name of each band was derived from a characteristic food source. For example, the people at Pyramid Lake were known as the Cui Ui Ticutta (meaning " Cui-ui eaters", or trout eaters). The people of the Lovelock area were known as the Koop Ticutta , meaning "ground-squirrel eaters" and

3850-451: The new settlers. Because of their change from a nomadic to a sedentary lifestyle , women were relied upon more heavily for both their full-time employment and at-home work. In some modern Northern Paiute tribes, men work in "seasonal jobs on the ranches, in the mines, and as caretakers in the nearby motels" and women work "in the laundry, the bakery, in homes and motels as domestics, and in the country hospital". They gathered Pinyon nuts in

3920-484: The outer shell, the inner shell will decay and be lost, leaving the person dead in reality. A shaman, however, would take an ill person (physically or spiritually ill) and use the power from the universe to heal him. In many cases, a shaman will utilize various mediums, such as a rattle, smoke, and songs, to incite the power of the universe. Estimates for the pre-contact populations of most native groups in California have varied substantially. Alfred L. Kroeber thought that

3990-752: The people of the Carson Sink were known as the Toi Ticutta meaning " tule eaters". The Kucadikadi of Mono County, California are the " brine fly eaters". Relations among the Northern Paiute and their Shoshone neighbors were generally peaceful. There is no sharp distinction between the Northern Paiute and Western Shoshone or Sosone . Relations with the Waasseoo or Washoe people, who were culturally and linguistically very different, were not so peaceful. These differences in lifestyle and language could be because Northern Paiute may have moved from southern regions to

4060-548: The powers of nature and the universe, shamans would frequently visit sacred sites. These sites can be found throughout the Great Basin and the American West. They include "mountains, caves, waterways, and unique geological formations." One such site is called the Parowan Gap and is sacred to the Paiute (see image). These sacred sites are where shamans performed many of their duties, including curing, rainmaking , warfare, fighting, or sorcery ." Shamans were and are an integral part of

4130-536: The region of the southern Sierra Nevada as the homeland of Proto-Numic approximately two millennia ago. A mitochondrial DNA study from 2001 supports this linguistic hypothesis. The anthropologist Peter N. Jones thinks this evidence to be of a circumstantial nature, but this is a distinctly minority opinion among specialists in Numic. David Shaul has proposed that the Southern Numic languages spread eastward long before

4200-502: The risk of subsequent infection, including in the setting of increased circulation of more infectious variants. ..." Immunity is determined genetically. Genomes in humans and animals encode the antibodies and numerous other immune response genes. While many of these genes are generally required for active and passive immune responses (see sections above), there are also many genes that appear to be required for very specific immune responses. For instance, Tumor Necrosis Factor (TNF)

4270-428: The same pathogen later. A fetus naturally acquires passive immunity from its mother during pregnancy. Maternal passive immunity is antibody -mediated immunity. The mother's antibodies (MatAb) are passed through the placenta to the fetus by an FcRn receptor on placental cells. This occurs around the third month of gestation . IgG is the only antibody isotype that can pass through the placenta. Passive immunity

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4340-409: The term by referring to polio vaccine , measles vaccine etc. Passive immunity is the immunity acquired by the transfer of ready-made antibodies from one individual to another. Passive immunity can occur naturally, such as when maternal antibodies are transferred to the foetus through the placenta, and can also be induced artificially, when high levels of human (or horse ) antibodies specific for

4410-443: The transfer of "sensitized" or activated T-cells from one individual into another. It is rarely used in humans because it requires histocompatible (matched) donors, which are often difficult to find. In unmatched donors this type of transfer carries severe risks of graft versus host disease . It has, however, been used to treat certain diseases including some types of cancer and immunodeficiency . This type of transfer differs from

4480-465: The tribe chanted and acted out the stories to the beat of a drum with people dancing. The Northern Paiute origin story, among many other important and formative legends, was passed on orally from tribal elders to younger tribe members and from grandmothers and grandfathers to grandchildren. Many of their stories and much of their history is passed on orally even today. Gender roles among the Northern Paiute did not stand out in society. Men and women divided

4550-554: The west in 1721 by lady Montagu" is quite not accurate and should be rendered "first promoted in the west, by lady Montague, in 1721". Because, as you can read here https://en.wikipedia.org/wiki/Variolation , the procedure was already known in Wales: "The method was first used in China, India, parts of Africa and the Middle East before it was introduced into England and North America in the 1720s in

4620-501: The woman while the two bad people were subject to the man. The two sets of pairs (good and bad) left the man and woman. Each pair created fire: the two good people made a fire with minimal smoke, the two bad people made a fire with thick smoke. This made them enemies, even before foreigners plotted them against each other later on. War and strife have existed ever since. While several other variations of these stories are told, they all share some similar events and characters. Namely Nűműzóho

4690-423: The work between each other the most traditional way: women made household tools, gathered fruit and seeds, cooked, cleaned, cared for the children, and made the clothing, while men hunted and protected their families. Men also taught their sons how to hunt and fish as a means to pass on a survival skill. Both sexes took part in storytelling, artwork and medicine, and traditional medicine. As the Northern Paiute entered

4760-456: Was exposed to the miasma in a swamp, in evening air, or breathing air in a sickroom or hospital ward, they could catch a disease. Since the 19th century, communicable diseases came to be viewed as being caused by germs/microbes. The modern word "immunity" derives from the Latin immunis, meaning exemption from military service, tax payments or other public services. The first scientist who developed

4830-417: Was increasingly referred to as variolation , and it became common practice to use this term without regard for chronology. The success and general acceptance of Jenner's procedure would later drive the general nature of vaccination developed by Pasteur and others towards the end of the 19th century. In 1891, Pasteur widened the definition of vaccine in honour of Jenner, and it then became essential to qualify

4900-555: Was the phonemic split of Proto-Numic geminate consonants into geminate consonants and preaspirated consonants. The conditioning factors involve stress shifts and are complex. The preaspirated consonants surfaced as voiceless fricatives, often preceded by a voiceless vowel. Shoshoni and Comanche have both lost the velar nasals, merging them with *n or turning them into velar nasal-stop clusters. In Comanche, nasal-stop clusters have become simple stops, but p and t from these clusters do not lenite intervocalically. This change postdates

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