Pancuronium (trademarked as Pavulon ) is an aminosteroid muscle relaxant with various medical uses. It is used in euthanasia and is used in some states as the second of three drugs administered during lethal injections in the United States.
90-420: Pancuronium is a typical non-depolarizing curare -mimetic muscle relaxant . It competitively inhibits the nicotinic acetylcholine receptor at the neuromuscular junction by blocking the binding of acetylcholine . It has slight vagolytic activity, causing an increase in heart rate, but no ganglioplegic (i.e., blocking ganglions ) activity. It is a very potent muscle relaxant drug, with an ED95 (i.e.,
180-414: A United Nations High Commissioner for Human Rights (established 1993) and an International Criminal Court (established 2002). Amnesty continued to work on a wide range of issues and world events. For example, South African groups joined in 1992 and hosted a visit by Pierre Sané to meet with the apartheid government to press for an investigation into allegations of police abuse, an end to arms sales to
270-412: A hyperpolarization . Usage of the term "depolarization" in biology differs from its use in physics, where it refers to situations in which any form of polarity ( i.e. the presence of any electrical charge, whether positive or negative) changes to a value of zero. Depolarization is sometimes referred to as "hypopolarization" (as opposed to hyp er polarization). The process of depolarization
360-705: A lethal injection in administration of the death penalty in some parts of the United States . Like all non-depolarising muscle relaxants, pancuronium has no effect on level of consciousness. Therefore, if the anaesthetic used is insufficient, the individual may be awake but unable to cry out or move due to the effect of the pancuronium. There have been several civil lawsuits alleging similar failures of adequate anaesthesia during general surgical procedures. These have been largely due to improper or insufficient dosages of anaesthetic in concert with normal dosages of muscle relaxants such as pancuronium. In 2007, Michael Munro,
450-892: A "ploy to divert attention" from their activities which were in clear contravention of laid down Indian laws. Amnesty International received permission only once in Dec 2000, since then it had been denied Foreign Contribution permission under the Foreign Contribution Act by successive Governments. However, in order to circumvent the FCRA regulations, Amnesty UK remitted large amounts of money to four entities registered in India by classifying it as Foreign Direct Investment (FDI). The current Prime Minister of India, Narendra Modi , has been criticized by foreign medias for harming civil society in India, specifically by targeting advocacy groups. India has cancelled
540-698: A "toxic culture" of workplace bullying , and found evidence of bullying , harassment , sexism and racism , after being asked to investigate the suicides of 30-year Amnesty veteran Gaetan Mootoo in Paris in May 2018 (who left a note citing work pressures), and 28-year-old intern Rosalind McGregor in Geneva in July 2018. In April 2019, Amnesty International's deputy director for research in Europe, Massimo Moratti, warned that if extradited to
630-404: A December 2018 filing by Saudi dissident Omar Abdulaziz, who claimed NSO's software targeted his phone during a period in which he was in regular contact with murdered journalist Jamal Kashoggi . In September 2019, European Commission President-elect Ursula von der Leyen created the new position of "Vice President for Protecting our European Way of Life ", who will be responsible for upholding
720-491: A Scottish neonatologist at Aberdeen Maternity Hospital , was cleared of malpractice by the General Medical Council Fitness to Practice panel after giving 23 times the standard dose of pancuronium to two dying neonates . Terminally ill, both dying babies were suffering from agonal gasping and violent body spasms, which was highly distressing for the parents to witness. Munro then administered pancuronium to
810-601: A briefing 26 Nov, during which he discussed other acts of terrorism. In August 2020, Amnesty International expressed concerns about what it called the "widespread torture of peaceful protesters" and treatment of detainees in Belarus. The organization also said that more than 1,100 people were killed by bandits in rural communities in northern Nigeria during the first six months of 2020. Amnesty International investigated what it called "excessive" and "unlawful" killings of teenagers by Angolan police who were enforcing restrictions during
900-407: A cell can establish a resting potential, however there is a typical pattern of generating this resting potential that many cells follow. The generation of a negative resting potential within the cell involves the utilization of ion channels, ion pumps, and voltage-gated ion channels by the cell. However, the process of generating the resting potential within the cell also creates an environment outside
990-438: A further decrease in voltage within the neuron below the resting potential. By hyperpolarizing a neuron, an inhibitory stimulus results in a greater negative charge that must be overcome for depolarization to occur. Excitation stimuli, on the other hand, increase the voltage in the neuron, which leads to a neuron that is easier to depolarize than the same neuron in the resting state. Regardless of it being excitatory or inhibitory,
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#17331065458041080-523: A prominent representative at the United Nations , had "undeclared private links to men alleged to be key players in a secretive network of global Islamists ", including the Muslim Brotherhood and Hamas . The Times also detailed instances where Hussein was alleged to have had inappropriately close relationships with the al-Qazzaz family, members of which were high-ranking government ministers in
1170-710: A response to the Republic of China (Taiwan)'s arrest and prosecution of Chen Yu-hsi, whom the Taiwan Garrison Command had alleged committed sedition by reading communist literature while studying in the United States. In 1976, Amnesty's British Section started a series of fund-raising events that came to be known as The Secret Policeman's Balls series. They were staged in London initially as comedy galas featuring what The Daily Telegraph called "the crème de la crème of
1260-399: A resting potential, that cell has the capacity to undergo depolarization. Depolarization is the process by which the membrane potential becomes less negative, facilitating the generation of an action potential. For this rapid change to take place within the interior of the cell, several events must occur along the plasma membrane of the cell. While the sodium–potassium pump continues to work,
1350-491: A signal from reaching the brain as opposed to stimulating the transmission of the signal. Endothelium is a thin layer of simple squamous epithelial cells that line the interior of both blood and lymph vessels. The endothelium that lines blood vessels is known as vascular endothelium, which is subject to and must withstand the forces of blood flow and blood pressure from the cardiovascular system. To withstand these cardiovascular forces, endothelial cells must simultaneously have
1440-501: A structure capable of withstanding the forces of circulation while also maintaining a certain level of plasticity in the strength of their structure. This plasticity in the structural strength of the vascular endothelium is essential to overall function of the cardiovascular system. Endothelial cells within blood vessels can alter the strength of their structure to maintain the vascular tone of the blood vessel they line, prevent vascular rigidity, and even help to regulate blood pressure within
1530-520: A toast to liberty". Researchers have never traced the alleged newspaper article in question. In 1960, Portugal was ruled by the Estado Novo government of António de Oliveira Salazar . The government was authoritarian in nature and strongly anti-communist , suppressing enemies of the state as anti-Portuguese. In his significant newspaper article " The Forgotten Prisoners ", Benenson later described his reaction as follows: Open your newspaper any day of
1620-399: Is about 120–180 minutes in healthy adults. The effects of pancuronium can be at least partially reversed by anticholinesterasics , such as neostigmine , pyridostigmine , and edrophonium . Workers at Organon were inspired by the structure of the aminosteroid alkaloid malouetine to develop a series of aminosteroid neuromuscular blockers based on an androstane nucleus, culminating in
1710-417: Is broken when rod cells are exposed to light; the absorption of light by the rod cell causes the channels that had facilitated the entry of sodium and calcium into the rod cell to close. When these channels close, the rod cells produce fewer neurotransmitters, which is perceived by the brain as an increase in light. Therefore, in the case of rod cells and their associated neurons, depolarization actually prevents
1800-420: Is created by increasing the concentration of sodium outside the cell and increasing the concentration of potassium within the cell. While there is an excessive amount of potassium in the cell and sodium outside the cell, the generated resting potential maintains the closure of voltage-gated ion channels in the plasma membrane. This not only prevents the diffusion of ions pumped across the membrane but also involves
1890-422: Is entirely dependent upon the intrinsic electrical nature of most cells. When a cell is at rest, the cell maintains what is known as a resting potential . The resting potential generated by nearly all cells results in the interior of the cell having a negative charge compared to the exterior of the cell. To maintain this electrical imbalance, ions are transported across the cell's plasma membrane. The transport of
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#17331065458041980-408: Is negatively charged relative to the cell's exterior. This difference in charge is called the cell's membrane potential . In the process of depolarization, the negative internal charge of the cell temporarily becomes more positive (less negative). This shift from a negative to a more positive membrane potential occurs during several processes, including an action potential . During an action potential,
2070-674: Is painless, or less cruel than other forms of execution. The United Kingdom bans the export of pancuronium bromide to the United States due to its use in lethal injections, but not to the Netherlands or Belgium. Pancuronium was used in Efren Saldivar 's killing spree. It was also used by the Skin Hunters to kill patients in the Polish city of Łódź . Pavulon was also used by Richard Angelo in 1987 to kill at least ten patients under his care at
2160-421: Is ultimately re-established by the closing of all voltage-gated ion channels and the activity of the sodium potassium ion pump. Depolarization is essential to the functions of many cells in the human body, which is exemplified by the transmission of stimuli both within a neuron and between two neurons. The reception of stimuli, neural integration of those stimuli, and the neuron's response to stimuli all rely upon
2250-555: The African Great Lakes region and the abolition of the death penalty. In particular, Amnesty International brought attention to violations committed on specific groups, including refugees , racial/ethnic/religious minorities, women and those executed or on Death Row . In 1995, when AI wanted to promote how Shell Oil Company was involved with the execution of an environmental and human-rights activist Ken Saro-Wiwa in Nigeria, it
2340-624: The Good Samaritan Hospital in New York. Depolarization In biology , depolarization or hypopolarization is a change within a cell , during which the cell undergoes a shift in electric charge distribution, resulting in less negative charge inside the cell compared to the outside. Depolarization is essential to the function of many cells, communication between cells, and the overall physiology of an organism. Most cells in higher organisms maintain an internal environment that
2430-555: The Metropolitan Police . Lord Hoffman had an indirect connection with Amnesty International, and this led to an important test for the appearance of bias in legal proceedings in UK law. There was a suit against the decision to release Senator Pinochet, taken by the then British Home Secretary Jack Straw, before that decision had actually been taken, in an attempt to prevent the release of Senator Pinochet. The English High Court refused
2520-459: The nicotinic agonists , suxamethonium and decamethonium . Amnesty International Amnesty International (also referred to as Amnesty or AI ) is an international non-governmental organization focused on human rights , with its headquarters in the United Kingdom. The organization says it has more than ten million members and supporters around the world. The stated mission of
2610-510: The threshold potential , depolarization continues from the axon hillock down the axon. The surge of depolarization traveling from the axon hillock to the axon terminal is known as an action potential . Action potentials reach the axon terminal, where the action potential triggers the release of neurotransmitters from the neuron. The neurotransmitters that are released from the axon continue on to stimulate other cells such as other neurons or muscle cells. After an action potential travels down
2700-407: The voltage-gated sodium and calcium channels that had been closed while the cell was at resting potential are opened in response to an initial change in voltage. As a change in the neuronal charge leads to the opening of voltage-gated sodium channels, this results in an influx of sodium ions down their electrochemical gradient . Sodium ions enter the cell, and they contribute a positive charge to
2790-413: The "Appeal for Amnesty, 1961" and September 1962 the organization had been known simply as "Amnesty". By the mid-1960s, Amnesty International's global presence was growing and an International Secretariat and International Executive Committee were established to manage Amnesty International's national organizations, called "Sections", which had appeared in several countries. They were secretly supported by
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2880-536: The British Campaign for Nuclear Disarmament as well as becoming head of Quaker Peace and Social Witness . In his memoirs, Benenson described him as "a partner in the launching of the project". In consultation with other writers, academics and lawyers and, in particular, Alec Digges, they wrote via Louis Blom-Cooper to David Astor , editor of The Observer newspaper, who, on 28 May 1961, published Benenson's article "The Forgotten Prisoners". The article brought
2970-596: The British comedy world" including members of comedy troupe Monty Python , and later expanded to also include performances by leading rock musicians. The series was created and developed by Monty Python alumnus John Cleese and entertainment industry executive Martin Lewis working closely with Amnesty staff members Peter Luff (assistant director of Amnesty 1974–1978) and subsequently with Peter Walker (Amnesty Fund-Raising Officer 1978–1982). Cleese, Lewis and Luff worked together on
3060-727: The British government at the time. The international movement was starting to agree on its core principles and techniques. For example, the issue of whether or not to adopt prisoners who had advocated violence, like Nelson Mandela , brought unanimous agreement that it could not give the name of "Prisoner of Conscience" to such prisoners. Aside from the work of the library and groups, Amnesty International's activities were expanding to helping prisoners' families, sending observers to trials, making representations to governments, and finding asylum or overseas employment for prisoners. Its activity and influence were also increasing within intergovernmental organizations; it would be awarded consultative status by
3150-484: The Enforcement Directorate has said the investigation could take three months to complete. On 30 October 2018, Amnesty called for the arrest and prosecution of Nigerian security forces claiming that they used excessive force against Shi'a protesters during a peaceful religious procession around Abuja, Nigeria. At least 45 were killed and 122 were injured during the event. In November 2018, Amnesty reported
3240-540: The Treatment of Prisoners and of existing humanitarian conventions; to secure ratifications of the two UN Covenants on Human Rights in 1976, and was instrumental in obtaining additional instruments and provisions forbidding the practice of maltreatment. Consultative status was granted at the Inter-American Commission on Human Rights in 1972. Amnesty International established its Japan chapter in 1970, in part
3330-664: The U.N. Human Rights Council is at stake. Since joining the council, Saudi Arabia's dire human rights record at home has continued to deteriorate and the coalition it leads has unlawfully killed and injured thousands of civilians in the conflict in Yemen ." In December 2016, Amnesty International revealed that Voiceless Victims , a fake non-profit organization which claims to raise awareness for migrant workers who are victims of human rights abuses in Qatar , had been trying to spy on their staff. In October 2018, an Amnesty International researcher
3420-1257: The UN to act promptly to implement the mission's recommendations. In February 2010, Amnesty suspended Gita Sahgal , its gender unit head, after she criticized Amnesty for its links with Moazzam Begg , director of Cageprisoners . She said it was "a gross error of judgment" to work with "Britain's most famous supporter of the Taliban". Amnesty responded that Sahgal was not suspended "for raising these issues internally... [Begg] speaks about his own views ..., not Amnesty International's". Among those who spoke up for Sahgal were Salman Rushdie , Member of Parliament Denis MacShane , Joan Smith , Christopher Hitchens , Martin Bright , Melanie Phillips , and Nick Cohen . In July 2011, Amnesty International celebrated its 50 years with an animated short film directed by Carlos Lascano , produced by Eallin Motion Art and Dreamlife Studio, with music by Academy Award-winner Hans Zimmer and nominee Lorne Balfe. In August 2012, Amnesty International's chief executive in India sought an impartial investigation, led by
3510-632: The US government's detention facility at Guantanamo Bay, Cuba , to a Soviet Gulag . During the first half of the new decade, Amnesty International turned its attention to violence against women , controls on the world arms trade , concerns surrounding the effectiveness of the UN, and ending torture. With its membership close to two million by 2005, Amnesty continued to work for prisoners of conscience. In 2007, AI's executive committee decided to support access to abortion "within reasonable gestational limits...for women in cases of rape, incest or violence, or where
3600-527: The United Nations' Universal Declaration of Human Rights (UDHR), played a series of concerts on five continents over six weeks. Both tours featured some of the most famous musicians and bands of the day. Throughout the 1990s, Amnesty continued to grow, to a membership of over seven million in over 150 countries and territories, led by Senegalese Secretary General Pierre Sané . At the intergovernmental level, Amnesty International argued in favour of creating
3690-504: The United Nations, the Council of Europe and UNESCO before the decade ended. In 1966, Benenson suspected that the British government in collusion with some Amnesty employees had suppressed a report on British atrocities in Aden. He began to suspect that many of his colleagues were part of a British intelligence conspiracy to subvert Amnesty, but he could not convince anybody else at AI. Later in
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3780-601: The United Nations, to render justice to those affected by war crimes in Sri Lanka. On 18 August 2014, in the wake of demonstrations sparked by people protesting about the fatal police shooting of Michael Brown , an unarmed 18-year-old who assaulted a police officer and then resisted arrest, and subsequent acquittal of Darren Wilson, the officer who shot him, Amnesty International sent a 13-person contingent of human rights activists to seek meetings with officials as well as to train local activists in non-violent protest methods. This
3870-772: The United States, WikiLeaks founder Julian Assange would face the "risk of serious human rights violations, namely detention conditions, which could violate the prohibition of torture". On 14 May 2019, Amnesty International filed a petition with the District Court of Tel Aviv, Israel, seeking a revocation of the export licence of surveillance technology firm NSO Group . The filing states that "staff of Amnesty International have an ongoing and well-founded fear they may continue to be targeted and ultimately surveilled" by NSO technology. Other lawsuits have also been filed against NSO in Israeli courts over alleged human-rights abuses, including
3960-408: The ability of neurons to utilize depolarization to transmit stimuli either within a neuron or between neurons. Stimuli to neurons can be physical, electrical, or chemical, and can either inhibit or excite the neuron being stimulated. An inhibitory stimulus is transmitted to the dendrite of a neuron, causing hyperpolarization of the neuron. The hyperpolarization following an inhibitory stimulus causes
4050-401: The activity of potassium leak channels, allowing a controlled passive efflux of potassium ions, which contributes to the establishment of the negative resting potential. Additionally, despite the high concentration of positively-charged potassium ions, most cells contain internal components (of negative charge), which accumulate to establish a negative inner charge. After a cell has established
4140-638: The administration of Mohammed Morsi and Muslim Brotherhood leaders at the time. Ms Hussein denied supporting the Muslim Brotherhood and told Amnesty that "any connections are purely circumstantial". In June 2016, Amnesty International called on the United Nations General Assembly to "immediately suspend" Saudi Arabia from the UN Human Rights Council . Richard Bennett, head of Amnesty's UN Office, said: "The credibility of
4230-529: The application, and Senator Pinochet was released and returned to Chile. After 2000, Amnesty International's primary focus turned to the challenges arising from globalization and the reaction to the 11 September 2001 attacks in the United States. The issue of globalization provoked a major shift in Amnesty International policy, as the scope of its work was widened to include economic, social and cultural rights, an area that it had declined to work on in
4320-601: The arrest of 19 or more rights activists and lawyers in Egypt . The arrests were made by the Egyptian authorities as part of the regime's ongoing crackdown on dissent. One of the arrested was Hoda Abdel-Monaim, a 60-year-old human rights lawyer and former member of the National Council for Human Rights. Amnesty reported that following the arrests Egyptian Coordination for Rights and Freedoms (ECRF) decided to suspend its activities due to
4410-527: The authority and capabilities of government leaders. Aakar Patel, the executive director of the Indian branch claimed, "The Enforcement Directorate's raid on our office today shows how the authorities are now treating human rights organizations like criminal enterprises, using heavy-handed methods. On Sep 29, the Ministry of Home Affairs said Amnesty International using "glossy statements" about humanitarian work etc. as
4500-431: The axon of a neuron, the resting membrane potential of the axon must be restored before another action potential can travel the axon. This is known as the recovery period of the neuron, during which the neuron cannot transmit another action potential. The importance and versatility of depolarization within cells can be seen in the relationship between rod cells in the eye and their associated neurons. When rod cells are in
4590-418: The babies after advising the parents that this would ease their suffering and could also hasten death. It was on record that neither of the children's parents were unhappy with Munro's treatment. Amnesty International has objected to its use in lethal injections on the grounds that it "may mask the condemned prisoner's suffering during the execution," thereby leading observers to conclude that lethal injection
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#17331065458044680-416: The cardiovascular system. Endothelial cells accomplish these feats by using depolarization to alter their structural strength. When an endothelial cell undergoes depolarization, the result is a marked decrease in the rigidity and structural strength of the cell by altering the network of fibers that provide these cells with their structural support. Depolarization in vascular endothelium is essential not only to
4770-415: The cell decreases and approaches its resting potential once more. The sodium potassium pump works continuously throughout this process. The process of repolarization causes an overshoot in the potential of the cell. Potassium ions continue to move out of the axon so much that the resting potential is exceeded and the new cell potential becomes more negative than the resting potential. The resting potential
4860-445: The cell interior, causing a change in the membrane potential from negative to positive. The initial sodium ion influx triggers the opening of additional sodium channels ( positive-feedback loop ), leading to further sodium ion transfer into the cell and sustaining the depolarization process until the positive equilibrium potential is reached. Sodium channels possess an inherent inactivation mechanism that prompts rapid reclosure, even as
4950-441: The cell that favors depolarization. The sodium potassium pump is largely responsible for the optimization of conditions on both the interior and the exterior of the cell for depolarization. By pumping three positively charged sodium ions (Na ) out of the cell for every two positively charged potassium ions (K ) pumped into the cell, not only is the resting potential of the cell established, but an unfavorable concentration gradient
5040-515: The collapse of the Twin Towers in New York." In the years following the attacks, some believe that the gains made by human rights organizations over previous decades had possibly been eroded. Amnesty International argued that human rights were the basis for the security of all, not a barrier to it. Criticism came directly from the Bush administration and The Washington Post , when Khan, in 2005, likened
5130-442: The coronavirus pandemic. In May 2020, the organization raised concerns about security flaws in a COVID-19 contact tracing app mandated in Qatar . In September 2020, Amnesty shut down its India operations after the government froze its bank accounts due to alleged financial irregularities. On 2 November 2020, Amnesty International reported that 54 people – mostly Amhara women and children and elderly people – were killed by
5220-436: The dark, they are depolarized. In the rod cells, this depolarization is maintained by ion channels that remain open due to the higher voltage of the rod cell in the depolarized state. The ion channels allow calcium and sodium to pass freely into the cell, maintaining the depolarized state. Rod cells in the depolarized state constantly release neurotransmitters which in turn stimulate the nerves associated with rod cells. This cycle
5310-538: The deaths of more than 1,400 Palestinians and 13 Israelis. The 117-page Amnesty report charged Israeli forces with killing hundreds of civilians and wanton destruction of thousands of homes. Amnesty found evidence of Israeli soldiers using Palestinian civilians as human shields. A subsequent United Nations Fact Finding Mission on the Gaza Conflict was carried out; Amnesty stated that its findings were consistent with those of Amnesty's own field investigation, and called on
5400-400: The depolarization is so large that the potential difference across the cell membrane briefly reverses polarity, with the inside of the cell becoming positively charged. The change in charge typically occurs due to an influx of sodium ions into a cell, although it can be mediated by an influx of any kind of cation or efflux of any kind of anion . The opposite of a depolarization is called
5490-756: The development of pancuronium bromide. Pancuronium is designed to mimic the action of two molecules of acetylcholine with the quaternary nitrogen atoms spaced rigidly apart by the steroid rings at a distance of ten atoms (interonium distance). Decamethonium and suxamethonium also have this same interonium distance. Pancuronium is used with general anesthesia in surgery for muscle relaxation and as an aid to intubation or ventilation. It does not have sedative or analgesic effects. Side-effects include moderately raised heart rate and thereby arterial pressure and cardiac output, excessive salivation , apnea and respiratory depression , rashes , flushing , and sweating . The muscular relaxation can be dangerous in
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#17331065458045580-426: The director of Amnesty, said, "Social media re-energises the idea of the global citizen". James M. Russell notes how the drive for profit from private media sources conflicts with the stories that AI wants to be heard. Amnesty International became involved in the legal battle over Augusto Pinochet , former Chilean dictator, who sought to avoid extradition to Spain to face charges after his arrest in London in 1998 by
5670-432: The dose that causes 95% depression of muscle twitch response) of only 60 μg/kg body weight. Onset of action is relatively slow compared to other similar drugs, in part due to its low dose: an intubating dose takes 3–6 minutes for full effect. Clinical effects (muscle activity lower than 25% of physiological) last for about 100 minutes. The time needed for full (over 90% muscle activity) recovery after single administration
5760-540: The first two shows (1976 and 1977). Cleese, Lewis and Walker worked together on the 1979 and 1981 shows, the first to carry what The Daily Telegraph described as the "rather brilliantly re-christened" Secret Policeman's Ball title. The organization was awarded the 1977 Nobel Peace Prize for its "defence of human dignity against torture " and the United Nations Prize in the Field of Human Rights in 1978. During
5850-525: The front page of the British newspaper The Observer , Benenson wrote about two students who toasted to freedom in Portugal and four other people who had been jailed in other nations because of their beliefs. AI's original focus was prisoners of conscience , with its remit widening in the 1970s, under the leadership of Seán MacBride and Martin Ennals , to include miscarriages of justice and torture . In 1977, it
5940-482: The grounds that it was bugged and infiltrated by the secret services, and said that he could no longer live in a country where such activities were tolerated. (See Relationship with the British Government ) Amnesty International's membership increased from 15,000 in 1969 to 200,000 by 1979. At the intergovernmental level Amnesty International pressed for the application of the UN's Standard Minimum Rules for
6030-492: The hostile environment towards civil society in the country. On 5 December 2018, Amnesty International strongly condemned the execution of the leaders of the " black realtors " gang Ihar Hershankou and Siamion Berazhnoy in Belarus . They were shot despite UN Human Rights Committee request for a delay. In February 2019, Amnesty International's management team offered to resign after an independent report found what it called
6120-427: The ions across the plasma membrane is accomplished through several different types of transmembrane proteins embedded in the cell's plasma membrane that function as pathways for ions both into and out of the cell, such as ion channels , sodium potassium pumps , and voltage-gated ion channels . The resting potential must be established within a cell before the cell can be depolarized. There are many mechanisms by which
6210-672: The launch of "Appeal for Amnesty, 1961", the aim of which was to mobilize public opinion, quickly and widely, in defence of these individuals, whom Benenson named "Prisoners of Conscience". The "Appeal for Amnesty" was reprinted by a large number of international newspapers. In the same year, Benenson had a book published, Persecution 1961 , which detailed the cases of nine prisoners of conscience investigated and compiled by Benenson and Baker (Maurice Audin, Ashton Jones , Agostinho Neto , Patrick Duncan , Olga Ivinskaya , Luis Taruc , Constantin Noica , Antonio Amat and Hu Feng ). In July 1961,
6300-581: The leadership had decided that the appeal would form the basis of a permanent organization, Amnesty, with the first meeting taking place in London. Benenson ensured that all three major political parties were represented, enlisting members of parliament from the Labour Party , the Conservative Party , and the Liberal Party . On 30 September 1962, it was officially named "Amnesty International". Between
6390-450: The membrane remains depolarized. During this equilibrium, the sodium channels enter an inactivated state, temporarily halting the influx of sodium ions until the membrane potential becomes negatively charged again. Once the cell's interior is sufficiently positively charged, depolarization concludes, and the channels close once more. After a cell has been depolarized, it undergoes one final change in internal charge. Following depolarization,
6480-409: The mid-to-late-1980s, Amnesty organized two major musical events took place to increase awareness of Amnesty and of human rights. The 1986 Conspiracy of Hope tour, which played five concerts in the US, and culminated in a daylong show, featuring some thirty-odd acts at Giants Stadium, and the 1988 Human Rights Now! world tour. Human Rights Now!, which was timed to coincide with the 40th anniversary of
6570-609: The organization is to campaign for "a world in which every person enjoys all of the human rights enshrined in the Universal Declaration of Human Rights and other international human rights instruments ." The organization has played a notable role on human rights issues due to its frequent citation in media and by world leaders. AI was founded in London in 1961 by the lawyer Peter Benenson . In what he called "The Forgotten Prisoners" and "An Appeal for Amnesty", which appeared on
6660-493: The past. Amnesty International felt this shift was important, not just to give credence to its principle of the indivisibility of rights, but because of what it saw as the growing power of companies and the undermining of many nation-states as a result of globalization. In the aftermath of 11 September attacks, the new Amnesty International Secretary General, Irene Khan , reported that a senior government official had said to Amnesty International delegates: "Your role collapsed with
6750-715: The pregnancy jeopardizes a mother's life or health". Amnesty International reported, concerning the Iraq War , on 17 March 2008, that despite claims the security situation in Iraq has improved in recent months, the human rights situation is disastrous, after the start of the war five years earlier in 2003. In 2009, Amnesty International accused Israel and the Palestinian Hamas movement of committing war crimes during Israel's January offensive in Gaza, called Operation Cast Lead , that resulted in
6840-483: The reader's attention to those "imprisoned, tortured or executed because his opinions or religion are unacceptable to his government" or, put another way, to violations, by governments, of articles 18 and 19 of the Universal Declaration of Human Rights (UDHR). The article described these violations occurring, on a global scale, in the context of restrictions to press freedom, to political oppositions, to timely public trial before impartial courts, and to asylum. It marked
6930-530: The registration of about 15,000 nongovernmental organizations under the Foreign Contribution Regulation Act (FCRA); the U.N. has issued statements against the policies that allow these cancellations to occur. Though nothing was found to confirm these accusations, the government plans on continuing the investigation and has frozen the bank accounts of all the offices in India . A spokesperson for
7020-539: The rule-of-law, internal security and migration. Amnesty International accused the European Union of "using the framing of the far right" by linking migration with security. On 24 November 2019, Anil Raj , a former Amnesty International board member, was killed by a car bomb while working with the United Nations Development Project. U.S. Secretary of State, Mike Pompeo announced Raj's death at
7110-401: The same year, there were further allegations, when the US government reported that Seán MacBride , the former Irish foreign minister and Amnesty's first chairman, had been involved with a Central Intelligence Agency funding operation. MacBride denied knowledge of the funding, but Benenson became convinced that MacBride was a member of a CIA network. Benenson resigned as Amnesty's president on
7200-509: The seriously ill and it can accumulate leading to extended weakness. Pancuronium is not preferable in long-term use in ICU-ventilated patients. In Belgium and the Netherlands , pancuronium is recommended in the protocol for euthanasia . After administering sodium thiopental to induce coma, pancuronium is delivered in order to stop breathing. Pancuronium is also used as one component of
7290-411: The stimulus travels down the dendrites of a neuron to the cell body for integration. Once the stimuli have reached the cell body, the nerve must integrate the various stimuli before the nerve can respond. The stimuli that have traveled down the dendrites converge at the axon hillock , where they are summed to determine the neuronal response. If the sum of the stimuli reaches a certain voltage, known as
7380-616: The structural integrity of endothelial cells, but also to the ability of the vascular endothelium to aid in the regulation of vascular tone, prevention of vascular rigidity, and the regulation of blood pressure. Depolarization occurs in the four chambers of the heart: both atria first, and then both ventricles. This process continues regularly, unless there is a problem in the heart. There are drugs, called depolarization blocking agents , that cause prolonged depolarization by opening channels responsible for depolarization and not allowing them to close, preventing repolarization. Examples include
7470-415: The voltage-gated sodium ion channels that had been open while the cell was undergoing depolarization close again. The increased positive charge within the cell now causes the potassium channels to open. Potassium ions (K ) begin to move down the electrochemical gradient (in favor of the concentration gradient and the newly established electrical gradient). As potassium moves out of the cell the potential within
7560-521: The week and you will find a story from somewhere of someone being imprisoned, tortured or executed because his opinions or religion are unacceptable to his government... The newspaper reader feels a sickening sense of impotence. Yet if these feelings of disgust could be united into common action, something effective could be done. Benenson worked with his friend Eric Baker – a member of the Religious Society of Friends who had been involved in funding
7650-599: Was abducted and beaten while observing demonstrations in Magas, the capital of Ingushetia, Russia. On 25 October, federal officers raided the Bengaluru office for 10 hours on a suspicion that the organization had violated foreign direct investment guidelines on the orders of the Enforcement Directorate . Employees and supporters of Amnesty International say this is an act to intimidate organizations and people who question
7740-483: Was awarded the Nobel Peace Prize . In the 1980s, its secretary general was Thomas Hammarberg , succeeded in the 1990s by Pierre Sané . In the 2000s, it was led by Irene Khan . Amnesty draws attention to human rights abuses and campaigns for compliance with international laws and standards. It works to mobilize public opinion to generate pressure on governments where abuse takes place. Amnesty International
7830-573: Was founded in London in July 1961 by English barrister Peter Benenson , who had previously been a founding member of the UK law reform organization JUSTICE. Benenson was influenced by his friend Louis Blom-Cooper , who led a political prisoners' campaign. According to Benenson's own account, he was travelling on the London Underground on 19 November 1960 when he read that two Portuguese students from Coimbra had been sentenced to seven years of imprisonment in Portugal for allegedly "having drunk
7920-458: Was over the issue of whether it would be appropriate for an anti-racism campaign with a "single focus". The Jewish Chronicle noted that Amnesty International had previously published a report on discrimination against Muslims in Europe. In August 2015, The Times reported that Yasmin Hussein, then Amnesty's director of faith and human rights and previously its head of international advocacy and
8010-422: Was stopped. Newspapers and advertising companies refused to run AI's ads because Shell Oil was a customer of theirs as well. Shell's main argument was that it was drilling oil in a country that already violated human rights and had no way to enforce human-rights policies. To combat the buzz that AI was trying to create, it immediately publicized how Shell was helping to improve overall life in Nigeria. Salil Shetty ,
8100-425: Was the first time that the organization has deployed such a team to the United States. In the 2015 annual Amnesty International UK conference, delegates narrowly voted (468 votes to 461) against a motion proposing a campaign against antisemitism in the UK. The debate on the motion formed a consensus that Amnesty should fight "discrimination against all ethnic and religious groups", but the division among delegates
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