The Predicted Aligned Error ( PAE ) is a quantitative output produced by AlphaFold , a protein structure prediction system developed by DeepMind . PAE estimates the expected positional error for each residue in a predicted protein structure if it were aligned to a corresponding residue in the true protein structure. This measurement helps scientists assess the confidence in the relative positions and orientations of different parts of the predicted protein model.
11-1062: For the acronym, see PAE . [REDACTED] Look up pae in Wiktionary, the free dictionary. Pae may refer to: Places [ edit ] Pae River , former name of the Taedong River in Pyongyang, Korea Pae, Tallinn , subdistrict of Lasnamäe District, Tallinn, Estonia Pae, Padise Parish , village in Padise Parish, Harju County, Estonia Pae, Rapla County , village in Kehtna Parish, Rapla County, Estonia People [ edit ] Main article: Bae (surname) Yustinus Pae (born 1983), Indonesian footballer Pae Gil-su (born 1972), North Korean gymnast Mark Pae (born 1926), Anglican bishop Pae Tal-jun (born 1972), North Korean politician Other uses [ edit ] Pae ,
22-561: A United States defense contractor Post-autistic economics , a criticism of neoclassical economics Provisional Admission Exercise , an interim exercise/period in Singapore education Patent assertion entity , a patent troll company See also [ edit ] Large Physical Address Extension (LPAE), in the ARM architecture All pages with titles beginning with PAE All pages with titles containing PAE Topics referred to by
33-497: A genus of wasps in the family Crabronidae PAE (Pacific Architects and Engineers) , a company owned by Platinum Investment Group. PAE , the IATA code for Paine Field, a commercial airport in suburban Seattle , United States PAE ( Prostatic artery embolization ), a medical procedure See also [ edit ] All pages with titles beginning with pae All pages with titles containing pae Topics referred to by
44-763: A percentage that rates the efficiency of a power amplifier Post Antibiotic Effect , the period of time following removal of an antibiotic drug during which there is no growth of the target organism Port Access Entity, in the IEEE 802.1X networking environment Primary amoebic encephalitis, another name for primary amoebic meningoencephalitis Prostatic artery embolization , a treatment for benign prostatic hyperplasia Places [ edit ] City of Port Adelaide Enfield , South Australia Paine Field (IATA airport code), an airport in Everett, Washington Other uses [ edit ] Pacific Architects and Engineers ,
55-657: Is different from Wikidata All article disambiguation pages All disambiguation pages PAE (disambiguation) (Redirected from PAE (disambiguation) ) This page is about the acronym. For other uses, see Pae . [REDACTED] Look up PAE in Wiktionary, the free dictionary. PAE may refer to: Science and technology [ edit ] Predicted Aligned Error , AlphaFold output file format for errors of protein structure prediction Physical Address Extension , an x86 computer processor feature for accessing more than 4 gigabytes of RAM Power added efficiency ,
66-478: Is different from Wikidata All article disambiguation pages All disambiguation pages Predicted Aligned Error PAE is presented as a two-dimensional (2D) interactive plot where the color at coordinates (x, y) represents the predicted position error at residue x if the predicted and true structures were aligned on residue y . Lower PAE values for residue pairs from different domains suggest well-defined relative positions and orientations in
77-634: The model predicts well-defined relative positions and orientations for those domains. Higher PAE values for such residue pairs suggest that the relative positions and/or orientations of these domains in the 3D structure are uncertain and should not be interpreted. Although PAE provides valuable information, users should note that it is asymmetric; the PAE value for (x, y) may differ from the value for (y, x), particularly between loop regions with highly uncertain orientations. Moreover, while AlphaFold can make useful inter-domain predictions, intra-domain prediction accuracy
88-455: The nearest integer), and the field max_predicted_aligned_error gives the maximum possible PAE value, which is capped at 31.75 Å. The PAE is measured in Ångströms. A separately developed 3D viewer of PAE allows for more intuitive visualization. Interpretation of PAE values allows scientists to understand the level of confidence in the predicted structure of a protein: Lower PAE values between residue pairs from different domains indicate that
99-475: The prediction, while higher PAE values indicate uncertainty in the relative positions or orientations. Users can download the raw PAE data for all residue pairs in a custom JSON format for further analysis or visualization using a programming language such as Python. The format of the JSON file is as follows: In the JSON file, the field predicted_aligned_error provides the PAE value for each residue pair (rounded to
110-403: The same term [REDACTED] This disambiguation page lists articles associated with the title PAE . If an internal link led you here, you may wish to change the link to point directly to the intended article. Retrieved from " https://en.wikipedia.org/w/index.php?title=PAE&oldid=1257281098 " Category : Disambiguation pages Hidden categories: Short description
121-403: The same term [REDACTED] This disambiguation page lists articles associated with the title Pae . If an internal link led you here, you may wish to change the link to point directly to the intended article. Retrieved from " https://en.wikipedia.org/w/index.php?title=Pae&oldid=1126718093 " Category : Disambiguation pages Hidden categories: Short description
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