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93-686: The Mont Clare Bridge (also Phoenixville–Mont Clare Bridge ) is a crossing of the Schuylkill River between Mont Clare and Phoenixville in Pennsylvania , USA. The bridge was also referred to as the Intercounty Bridge , as it connects Montgomery and Chester counties. The bridge abuts a shorter county bridge across the Schuylkill Canal and towpath on the Mont Clare side to complete

186-494: A strain of coronavirus known as "severe acute respiratory syndrome coronavirus 2" ( SARS-CoV-2 ). COVID-19 is mainly transmitted when people breathe in air contaminated by droplets / aerosols and small airborne particles containing the virus. Infected people exhale those particles as they breathe, talk, cough, sneeze, or sing. Transmission is more likely the closer people are. However, infection can occur over longer distances, particularly indoors. The transmission of

279-419: A certain critical size, generally thought to be <100μm diameter, evaporate faster than they settle; due to that fact, they form respiratory aerosol particles that remain airborne for a long period of time over extensive distances. Infectivity can begin four to five days before the onset of symptoms. Infected people can spread the disease even if they are pre-symptomatic or asymptomatic . Most commonly,

372-521: A common problem with northern canals. The success of these projects and the rosy promise of anthracite (a new wonder fuel in the day) to alleviate energy problems spurred canal construction for the next decade in the east, and commercial opportunities funded three decades of investment from Illinois to the Atlantic Ocean, including the ambitious 1824 Main Line of Public Works bill to connect Philadelphia with

465-571: A concrete barrier was installed between the trail and the vehicle lanes. The original railing above the bridge edge was replaced with new railing. The new barrier was topped with the same railing on the Chester County half. The original December completion date was missed and then the project was further delayed by the COVID-19 pandemic. Although not completely finished, the Connector opened for use in

558-401: A gap between SRT segments west of Phoenixville and the exiting SRT between Mont Clare and Philadelphia. The sidewalk and unmarked bike lane, of the 1997 bridge, unofficially filled that gap for walkers and cyclists. But the sidewalk and bike lane were not built to trail standards. They would be congested during peak trail usage and were not protected from vehicular traffic. In September, 2012,

651-422: A higher risk of developing severe symptoms. Some complications result in death. Some people continue to experience a range of effects ( long COVID ) for months or years after infection, and damage to organs has been observed. Multi-year studies are underway to further investigate the long-term effects of the disease. COVID‑19 transmission occurs when infectious particles are breathed in or come into contact with

744-535: A hit by tossing it into the Schuylkill River, noting, "There's a spot in the Schuylkill River everybody uses. If they ever send divers down there, they'd be able to arm a small country." The Schuylkill River has been a plot point in several episodes of It's Always Sunny in Philadelphia . In the 2011 episode "Thunder Gun Express", Frank Reynolds , played by Danny DeVito , steals a tourist ferry and travels down

837-581: A passage at Gordon's Ford and at Fatland Ford, further downstream. In response, Washington maneuvered the Continental Army further west to protect his supply line and the Congress, then in York . This left Philadelphia lightly defended, leading to its capture . Gordon's Ford is mentioned in the writings of both Washington and Cornwallis. In the winter of 1843–1844, local businessman Joseph Whitaker , while in

930-423: A range of effects, such as fatigue , for prolonged periods after an initial COVID-19 infection. This is the result of a condition called long COVID , which can be described as a range of persistent symptoms that continue for months or years. Long-term damage to organs has been observed after the onset of COVID-19. Multi-year studies are underway to further investigate the protracted effects of long COVID. Reducing

1023-683: Is a contagious disease caused by the coronavirus SARS-CoV-2 . The first known case was identified in Wuhan , China, in December 2019. Most scientists believe the SARS-CoV-2 virus entered into human populations through natural zoonosis , similar to the SARS-CoV-1 and MERS-CoV outbreaks, and consistent with other pandemics in human history. Social and environmental factors including climate change , natural ecosystem destruction and wildlife trade increased

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1116-686: Is a novel severe acute respiratory syndrome coronavirus. It was first isolated from three people with pneumonia connected to the cluster of acute respiratory illness cases in Wuhan. All structural features of the novel SARS-CoV-2 virus particle occur in related coronaviruses in nature, particularly in Rhinolophus sinicus (Chinese horseshoe bats). Outside the human body, the virus is destroyed by household soap which bursts its protective bubble . Hospital disinfectants, alcohols, heat, povidone-iodine , and ultraviolet -C (UV-C) irradiation are also effective disinfection methods for surfaces. SARS-CoV-2

1209-571: Is associated with COVID-19 and is reported in as many as 88% of symptomatic cases. Published data on the neuropathological changes related with COVID-19 have been limited and contentious, with neuropathological descriptions ranging from moderate to severe hemorrhagic and hypoxia phenotypes , thrombotic consequences, changes in acute disseminated encephalomyelitis (ADEM-type), encephalitis and meningitis . Many COVID-19 patients with co-morbidities have hypoxia and have been in intensive care for varying lengths of time, confounding interpretation of

1302-433: Is available, guidelines and recommendations for hypertensive patients remain. The effect of the virus on ACE2 cell surfaces leads to leukocytic infiltration, increased blood vessel permeability, alveolar wall permeability, as well as decreased secretion of lung surfactants. These effects cause the majority of the respiratory symptoms. However, the aggravation of local inflammation causes a cytokine storm eventually leading to

1395-402: Is because pregnant women with COVID‑19 appear to be more likely to develop respiratory and obstetric complications that can lead to miscarriage , premature delivery and intrauterine growth restriction . Fungal infections such as aspergillosis , candidiasis , cryptococcosis and mucormycosis have been recorded in patients recovering from COVID‑19. COVID‑19 is caused by infection with

1488-522: Is closely related to the original SARS-CoV . It is thought to have an animal ( zoonotic ) origin. Genetic analysis has revealed that the coronavirus genetically clusters with the genus Betacoronavirus , in subgenus Sarbecovirus (lineage B) together with two bat-derived strains. It is 96% identical at the whole genome level to other bat coronavirus samples (BatCov RaTG13 ). The structural proteins of SARS-CoV-2 include membrane glycoprotein (M), envelope protein (E), nucleocapsid protein (N), and

1581-447: Is filmed by the Schuylkill River and the adjacent neighborhood of Manayunk . The Schuylkill is shown in the beginning of the 2015 video for "Looking Out for You" by Philadelphia indie rock band Joy Again . The 2017 video for "Pain", from A Deeper Understanding by Philadelphia rock band The War on Drugs , features the band floating down the river while performing on a barge. COVID-19 Coronavirus disease 2019 ( COVID-19 )

1674-598: Is held on the river near Boathouse Row , as is the annual BAYADA Home Health Care Regatta, featuring disabled rowers from all over the continent, and in autumn the annual Head of the Schuylkill Regatta takes place in Philadelphia. Also, the Stotesbury Cup Regatta , the biggest high school regatta in the world, takes place there. The Chinese sport of dragon boat racing was introduced to the United States on

1767-623: Is in heavily mined land, one ridgeline south of Tuscarora Lake along a drainage divide with the Little Schuylkill River , about a mile east of the village of Tuscarora and about a mile west of Tamaqua , at Tuscarora Springs in Schuylkill County . Tuscarora Lake is one source of the Little Schuylkill. The West Branch starts near Minersville and joins the eastern branch at the town of Schuylkill Haven . It then combines with

1860-461: Is known to have been on fire more than once throughout history, for example in November 1892 when the surface film of oil that had leaked from nearby oil works at Point Breeze , Philadelphia, was ignited by a match tossed carelessly from a boat, with fatal results. Silt and coal dust from upstream industries, particularly coal mining and washing operations in the headwaters, led to extensive silting of

1953-595: Is the cause of the bud release and the formation of the viral envelope. The N and E protein are accessory proteins that interfere with the host's immune response. Human angiotensin converting enzyme 2 (hACE2) is the host factor that SARS-CoV-2 virus targets causing COVID‑19. Theoretically, the usage of angiotensin receptor blockers (ARB) and ACE inhibitors upregulating ACE2 expression might increase morbidity with COVID‑19, though animal data suggest some potential protective effect of ARB; however no clinical studies have proven susceptibility or outcomes. Until further data

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2046-465: Is the viral component that attaches to the host receptor via the ACE2 receptors. It includes two subunits: S1 and S2. Studies have shown that S1 domain induced IgG and IgA antibody levels at a much higher capacity. It is the focus spike proteins expression that are involved in many effective COVID‑19 vaccines. The M protein is the viral protein responsible for the transmembrane transport of nutrients. It

2139-896: The Alpha variant (B.1.1.7, formerly called the UK variant), first found in London and Kent, the Beta variant (B.1.351, formerly called the South Africa variant), the Gamma variant (P.1, formerly called the Brazil variant), the Delta variant (B.1.617.2, formerly called the India variant), and the Omicron variant (B.1.1.529), which had spread to 57 countries as of 7 December. On December 19, 2023,

2232-807: The Chesapeake Bay to the left bank Potomac River across from the Powhatan Confederacy when traders first stopped in the Delaware River and settlers arrived in the first decade of the 1600s. With ample tributary streams, the Schuylkill was ground zero during the early years of the Beaver Wars , during which the Lenape tribe became tributary to the victorious Susquehannocks. The Susquehannocks were an Iroquoian people also often in contention with their relatives:

2325-771: The Erie people west and northwest through the gaps of the Allegheny in eastern Ohio and northwestern Pennsylvania (between the upper Allegheny River and Lake Erie), as well as the Five Nations of the Iroquois , another Amerindian confederation eastwards from the right bank of the Genesee River through the Finger Lakes region of upper New York down the St. Lawrence . The Lenape had settlements on

2418-559: The Grays Ferry section of Philadelphia , overlooking the Schuylkill River. In 2007 Beth Kephart published Flow: The Life and Times of Philadelphia's Schuylkill River , a series of poetic ruminations about the river. Philadelphia on the Fly , published in 2005, and Small Fry: The Lure of the Little , published in 2009 contain essays by Ron P. Swegman describing the experience of fly fishing along

2511-635: The Industrial Revolution : the Lehigh Coal Company and the Lehigh Coal & Navigation Company. Following White's plan, the latter company improved down river navigation on the Lehigh River , using his Bear Trap Locks design to deliver over 365 tons of anthracite to Philadelphia docks by December 1820, four years ahead of promises to Stockholders. The success, along with the pending opening of

2604-459: The Little Schuylkill River downstream in the town of Port Clinton . The Tulpehocken Creek joins it at the western edge of Reading . Wissahickon Creek joins it in northwest Philadelphia. Other major tributaries include: Maiden Creek , Manatawny Creek , French Creek , and Perkiomen Creek . The Schuylkill joins the Delaware River at the site of the former Philadelphia Navy Yard , now

2697-561: The Pennsylvania Railroad were vital shipping conduits from the second decade of the 19th century through the mid-20th century. The rise of trucking capabilities and state & county development of road and highway networks progressively took increasing amounts of business away from both competing transport industries. By the mid-1930s the canals inflexibility and a geographically limited pool of customers steadily shifting energy usage away from anthracite doomed most eastern canals, so

2790-464: The Schuylkill River Trail . There are efforts to extend both rail and trail farther upriver than they currently reach. The Schuylkill River Trail continues upriver from Norristown to Mont Clare , and designers plan to connect it to sections above Pottstown. SEPTA Regional Rail service currently does not go farther upriver than Norristown. Visions of resuming commuter rail service farther up

2883-572: The Spanish flu , Middle East respiratory syndrome , and Zika virus . In January 2020, the World Health Organization (WHO) recommended 2019-nCoV and 2019-nCoV acute respiratory disease as interim names for the virus and disease per 2015 guidance and international guidelines against using geographical locations or groups of people in disease and virus names to prevent social stigma . The official names COVID‑19 and SARS-CoV-2 were issued by

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2976-553: The War of 1812 , the two took delivery of an ark of anthracite coal which was notoriously difficult to combust reliably and experimented with ways to use it industrially, providing the knowledge to successfully begin resolving the ongoing decades long energy crises around eastern cities. The two then heavily backed the flagging effort to improve navigation on the Schuylkill, which efforts date back to legislation measures as early as 1762. By 1816, needing energy resources and disenchanted with

3069-482: The small intestine . The virus can cause acute myocardial injury and chronic damage to the cardiovascular system . An acute cardiac injury was found in 12% of infected people admitted to the hospital in Wuhan, China, and is more frequent in severe disease. Rates of cardiovascular symptoms are high, owing to the systemic inflammatory response and immune system disorders during disease progression, but acute myocardial injuries may also be related to ACE2 receptors in

3162-705: The spike protein (S). The M protein of SARS-CoV-2 is about 98% similar to the M protein of bat SARS-CoV, maintains around 98% homology with pangolin SARS-CoV, and has 90% homology with the M protein of SARS-CoV; whereas, the similarity is only around 38% with the M protein of MERS-CoV . The many thousands of SARS-CoV-2 variants are grouped into either clades or lineages . The WHO, in collaboration with partners, expert networks, national authorities, institutions and researchers, have established nomenclature systems for naming and tracking SARS-CoV-2 genetic lineages by GISAID , Nextstrain and Pango . The expert group convened by

3255-536: The 1860s Iron works, foundries, manufacturing mills, blast furnaces, rolling mills, rail yards , rail roads, warehouses and train stations sprang up throughout the valley. Tiny farm villages grew into vibrant company towns then transitioned into small cities as a major industry and supporting businesses transformed local economics and populations swelled. Restoration of the river has been funded by money left for that purpose in Benjamin Franklin 's will. The river

3348-538: The B.1 lineage. Several notable variants of SARS-CoV-2 emerged throughout 2020. Cluster 5 emerged among minks and mink farmers in Denmark . After strict quarantines and the slaughter of all the country's mink , the cluster was assessed to no longer be circulating among humans in Denmark as of 1 February 2021. As of December 2021 , there are five dominant variants of SARS-CoV-2 spreading among global populations:

3441-539: The CNS, possibly within an infected white blood cell. Research conducted when Alpha was the dominant variant has suggested COVID-19 may cause brain damage. Later research showed that all variants studied (including Omicron) killed brain cells, but the exact cells killed varied by variant. It is unknown if such damage is temporary or permanent. Observed individuals infected with COVID-19 (most with mild cases) experienced an additional 0.2% to 2% of brain tissue lost in regions of

3534-557: The COVID-19 infection may have different symptoms, and their symptoms may change over time. Three common clusters of symptoms have been identified: a respiratory symptom cluster with cough, sputum , shortness of breath , and fever; a musculoskeletal symptom cluster with muscle and joint pain, headache, and fatigue; and a cluster of digestive symptoms with abdominal pain, vomiting, and diarrhea. In people without prior ear, nose, or throat disorders, loss of taste combined with loss of smell

3627-650: The Lehigh, Delaware and Schuylkill Canals all ceased operations during the Great Depression years. The zooming rise of automobile ownership post-World War II, the development of suburbs, and dispersal of industrial buildings into far flung parks serviced by the government supported highways and new Interstate Highways doomed intercity rail transport; even as Interstate Commerce Committee regulations required railway operating companies to maintain passenger rail services past its economic viability—which costs further imperiled

3720-524: The Philadelphia Naval Business Center, just northeast of Philadelphia International Airport . The Schuylkill's name derives from the Dutch words schuilen , meaning to hide, and kil , meaning stream, apparently because of the "retired and hidden situation of its mouth". According to John Heckewelder , a missionary who worked among the local Lenape Indians , the native name for the river

3813-698: The Schuylkill River. In Jerry Spinelli 's 1990 young adult novel Maniac Magee , the protagonists's parents die when their commuter train plunges into the river. Much of the story takes place along the river in Two Mills, a fictionalized version of Norristown . The Schuylkill River is also the setting of the fictional estate White Acre in Elizabeth Gilbert 's 2013 novel The Signature of All Things , based on The Woodlands . The main protagonist in Ta-Nehisi Coates ' 2019 novel The Water Dancer first arrives in

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3906-497: The Schuylkill in 1983, and two major dragon boat regattas are held there in June and October of each year. Water skiing, swimming and other aquatic sports are also common outside of Philadelphia city limits. The Schuylkill River Trail , which generally follows the river bank, is a multi-use trail for walking, running, bicycling, rollerblading, and other outdoor activities. The trail presently runs from Philadelphia, through Manayunk to

3999-552: The Schuylkill lay within the territory of the Susquehannock and Lenape peoples. In 1682, William Penn founded the city of Philadelphia between the Schuylkill and Delaware rivers on lands purchased from the Lenape Indian tribe. The Schuylkill River became key in the development of the city and the surrounding region. While long used for transport, the river was made fully navigable via the Schuylkill Canal in 1825, followed by

4092-406: The Schuylkill valley (" Schuylkill Valley Metro ") have yet to become reality. The Schuylkill Expressway ( Interstate 76 ) and the U.S. Route 422 follow the course of the river from Philadelphia to Valley Forge to Reading. Above Reading, Pennsylvania Route 61 continues along the main river valley to Schuylkill Haven, then follows the east branch to Pottsville. U.S. Route 209 continues along

4185-486: The Schuylkill, noting that it is "the depository of all the unsolved crimes and murders in Philadelphia". In the 2013 episode "Mac Day", Mac , played by Rob McElhenney , films a stunt video that makes it look like he jumped into the river, after which his cousin Country Mac, played by Seann William Scott , shows him up by actually jumping into the river. The 2005 video for "Doesn't Remind Me" by hard rock band Audioslave

4278-472: The WHO declared that another distinctive variant, JN.1, had emerged as a "variant of interest". Though the WHO expected an increase in cases globally, particularly for countries entering winter, the overall global health risk was considered low. The SARS-CoV-2 virus can infect a wide range of cells and systems of the body. COVID‑19 is most known for affecting the upper respiratory tract (sinuses, nose, and throat) and

4371-759: The WHO on 11 February 2020 with COVID-19 being shorthand for "coronavirus disease 2019". The WHO additionally uses "the COVID‑19 virus" and "the virus responsible for COVID‑19" in public communications. The symptoms of COVID-19 are variable depending on the type of variant contracted, ranging from mild symptoms to a potentially fatal illness. Common symptoms include coughing , fever , loss of smell (anosmia) and taste (ageusia), with less common ones including headaches , nasal congestion and runny nose , muscle pain , sore throat , diarrhea , eye irritation , and toes swelling or turning purple, and in moderate to severe cases, breathing difficulties . People with

4464-547: The WHO recommended the labelling of variants using letters of the Greek alphabet , for example, Alpha , Beta , Delta , and Gamma , giving the justification that they "will be easier and more practical to discussed by non-scientific audiences". Nextstrain divides the variants into five clades (19A, 19B, 20A, 20B, and 20C), while GISAID divides them into seven (L, O, V, S, G, GH, and GR). The Pango tool groups variants into lineages , with many circulating lineages being classed under

4557-515: The brain connected to the sense of smell compared with uninfected individuals, and the overall effect on the brain was equivalent on average to at least one extra year of normal ageing; infected individuals also scored lower on several cognitive tests. All effects were more pronounced among older ages. The virus also affects gastrointestinal organs as ACE2 is abundantly expressed in the glandular cells of gastric , duodenal and rectal epithelium as well as endothelial cells and enterocytes of

4650-591: The brain found as complications leading to death in people infected with COVID‑19. Infection may initiate a chain of vasoconstrictive responses within the body, including pulmonary vasoconstriction – a possible mechanism in which oxygenation decreases during pneumonia. Furthermore, damage of arterioles and capillaries was found in brain tissue samples of people who died from COVID‑19. COVID‑19 may also cause substantial structural changes to blood cells , sometimes persisting for months after hospital discharge. A low level of blood lymphocytess may result from

4743-428: The brains of those who have died from COVID‑19, but these results need to be confirmed. While virus has been detected in cerebrospinal fluid of autopsies, the exact mechanism by which it invades the CNS remains unclear and may first involve invasion of peripheral nerves given the low levels of ACE2 in the brain. The virus may also enter the bloodstream from the lungs and cross the blood–brain barrier to gain access to

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4836-571: The citizens in funding an iron bridge over this river, before abandoning " pontifical works" on account of the French Revolution . Over the next few decades, industrialists Josiah White and protege and partner Erskine Hazard built iron industries at the Falls of the Schuylkill during the Jefferson's administration , where White built a suspension bridge with cables made from their wire mill. During

4929-409: The clear jelly liquid found in lung autopsies of people who died of COVID-19. One possibility addressed in medical research is that hyuralonic acid (HA) could be the leading factor for this observation of the clear jelly liquid found in the lungs, in what could be hyuralonic storm, in conjunction with cytokine storm . One common symptom, loss of smell, results from infection of the support cells of

5022-511: The closure of State Route 29 to a minimum. The project was kept to a short time line by reusing the existing bridge foundations, using steel girders, and an incentive clause in the contract. The new bridge opened in 1997. The new bridge was the first in Pennsylvania to include "shock transmission units", an earthquake damage mitigation technology. When Phoenixville opened their portion of the Schuylkill River Trail (SRT) in 2015, it still left

5115-729: The construction of the Reading Railroad Main Line in 1838 and the Schuylkill Branch of the Pennsylvania Railroad in 1884. Through these corridors, millions of tons of anthracite coal flowed down the Schuylkill from the Coal Region to its north in Northeast Pennsylvania . The canal was abandoned in 1931, while the Schuylkill Expressway was completed in 1959. Industrial pollution and mining silt plagued

5208-408: The counties and regional planners had issued a Request for Proposal to study improving the pedestrian and bicycle "Connector" on the bridge. Initial plans for the Connector were presented at an open house on June 12, 2013, and were met with favorable opinions. In October 2019, construction started on the Connector. The sidewalk and bike lane were replaced with a level 10 foot wide trail segment and

5301-522: The crossing. The crossing carries Bridge Street ( PA 29 ) and the Schuylkill River Trail . In early America, the crossing was a ford known originally as Indian or Indiantown Ford. Then successively as Gordon's, Starr's and Jacobs' Ford. The crossing gained some notoriety as Gordon's Ford when it was used by American and British troops during the American Revolutionary War . In the fall of 1777, British troops under Lord Cornwallis forced

5394-406: The data. Of people who show symptoms, 81% develop only mild to moderate symptoms (up to mild pneumonia ), while 14% develop severe symptoms ( dyspnea , hypoxia , or more than 50% lung involvement on imaging) that require hospitalization, and 5% of patients develop critical symptoms ( respiratory failure , septic shock , or multiorgan dysfunction ) requiring ICU admission. At least a third of

5487-588: The east branch of the river to its head in Tuscarora . In Philadelphia, Kelly Drive (formerly East River Drive), and Martin Luther King Jr. Drive (formerly West River Drive) flank the river. The Schuylkill River is popular with rowing , dragon boat , and outrigger paddling enthusiasts. The Schuylkill Navy was established on the riverside adjacent to the city of Philadelphia to promote amateur rowing in 1858. The Dad Vail Regatta , an annual rowing competition,

5580-716: The expression of ACE-2, thereby facilitating the SARS-Cov2 virus to enter cells and to replicate. A competition of negative feedback loops (via protective effects of interferon alpha) and positive feedback loops (via upregulation of ACE-2) is assumed to determine the fate of patients suffering from COVID-19. Additionally, people with COVID‑19 and acute respiratory distress syndrome (ARDS) have classical serum biomarkers of CRS, including elevated C-reactive protein (CRP), lactate dehydrogenase (LDH), D-dimer , and ferritin . Systemic inflammation results in vasodilation , allowing inflammatory lymphocytic and monocytic infiltration of

5673-428: The eyes, nose, or mouth. The risk is highest when people are in close proximity, but small airborne particles containing the virus can remain suspended in the air and travel over longer distances, particularly indoors. Transmission can also occur when people touch their eyes, nose or mouth after touching surfaces or objects that have been contaminated by the virus. People remain contagious for up to 20 days and can spread

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5766-521: The face. While drugs have been developed to inhibit the virus, the primary treatment is still symptomatic , managing the disease through supportive care , isolation , and experimental measures . During the initial outbreak in Wuhan , the virus and disease were commonly referred to as "coronavirus" and "Wuhan coronavirus", with the disease sometimes called "Wuhan pneumonia". In the past, many diseases have been named after geographical locations, such as

5859-464: The first operable sections of New York's Erie Canal spurred stockholders of the Schuylkill Canal to finally fund the works. A project which had languished for over a decade got capitalized and began operations in 1822—the same year the Lehigh companies combined into the Lehigh Coal & Navigation Company, having had to raise additional funds for repairs due to badly ice-damaged improvements,

5952-412: The five concrete arches spanned 103 feet (31 m), and the cost was US$ 103,250. In 1996 a contract was let to replace the 1916 bridge. The new bridge was designed by HDR, Inc. 's Pittsburgh office and Czop/Specter, Inc. of Worcester, Montgomery County, PA office. Construction was done by Allan A. Myers Inc. of Worcester, Pennsylvania . Many design decisions were based on the requirement to keep

6045-462: The founding of the Schuylkill Navy in 1858. In recent decades the Schuylkill River Trail cycle and foot path has been constructed along the river. The Schuylkill Heritage Corridor was designated a Pennsylvania Heritage Park in 1995 and a National Heritage Area in 2000 to promote the river's historic, environmental, and recreational significance. The source of the Schuylkill's eastern branch

6138-523: The heart. ACE2 receptors are highly expressed in the heart and are involved in heart function. A high incidence of thrombosis and venous thromboembolism occurs in people transferred to intensive care units with COVID‑19 infections, and may be related to poor prognosis. Blood vessel dysfunction and clot formation (as suggested by high D-dimer levels caused by blood clots) may have a significant role in mortality, incidents of clots leading to pulmonary embolisms , and ischaemic events (strokes) within

6231-456: The host cell. Following viral entry, COVID‑19 infects the ciliated epithelium of the nasopharynx and upper airways. Autopsies of people who died of COVID‑19 have found diffuse alveolar damage , and lymphocyte-containing inflammatory infiltrates within the lung. From the CT scans of COVID-19 infected lungs, white patches were observed containing fluid known as ground-glass opacity (GGO) or simply ground glass. This tended to correlate with

6324-469: The infection, children may develop paediatric multisystem inflammatory syndrome , which has symptoms similar to Kawasaki disease , which can be fatal. In very rare cases, acute encephalopathy can occur, and it can be considered in those who have been diagnosed with COVID‑19 and have an altered mental status. According to the US Centers for Disease Control and Prevention , pregnant women are at increased risk of becoming seriously ill from COVID‑19. This

6417-440: The lack of urgency found in other investors to accelerate the anemic and underfunded construction rate of the Schuylkill Canal, the two jumped to option the mining rights of the Lehigh Coal & Navigation Company , which disenchanted stockholders were giving up on. They then waited until a charter to improve the Lehigh went delinquent, resulting in two groups of investors forming two complementary companies in 1818 that jump-started

6510-472: The legislature, "obtained a charter for the incorporation of a company to erect a bridge over the Schuylkill at the site of th[e] ford". That summer, a wooden covered bridge was constructed, it was one of the longest in regional history. In early 1915, state highway engineers formally recommended to the County Commissioners that the bridge be replaced. Then fate took a hand and the covered bridge burned down on May 9, 1915. A temporary wooden replacement bridge

6603-800: The likelihood of such zoonotic spillover . The disease quickly spread worldwide, resulting in the COVID-19 pandemic . The symptoms of COVID‑19 are variable but often include fever, fatigue, cough, breathing difficulties , loss of smell , and loss of taste . Symptoms may begin one to fourteen days after exposure to the virus. At least a third of people who are infected do not develop noticeable symptoms . Of those who develop symptoms noticeable enough to be classified as patients, most (81%) develop mild to moderate symptoms (up to mild pneumonia ), while 14% develop severe symptoms ( dyspnea , hypoxia , or more than 50% lung involvement on imaging), and 5% develop critical symptoms ( respiratory failure , shock , or multiorgan dysfunction ). Older people are at

6696-450: The lower respiratory tract (windpipe and lungs). The lungs are the organs most affected by COVID‑19 because the virus accesses host cells via the receptor for the enzyme angiotensin-converting enzyme 2 (ACE2), which is most abundant on the surface of type II alveolar cells of the lungs. The virus uses a special surface glycoprotein called a " spike " to connect to the ACE2 receptor and enter

6789-409: The lung and the heart. In particular, pathogenic GM-CSF-secreting T cells were shown to correlate with the recruitment of inflammatory IL-6-secreting monocytes and severe lung pathology in people with COVID‑19. Lymphocytic infiltrates have also been reported at autopsy. Multiple viral and host factors affect the pathogenesis of the virus. The S-protein , otherwise known as the spike protein,

6882-447: The moment a person first becomes infected and the appearance of the first symptoms. The median delay for COVID-19 is four to five days possibly being infectious on 1–4 of those days. Most symptomatic people experience symptoms within two to seven days after exposure, and almost all will experience at least one symptom within 12 days. Most people recover from the acute phase of the disease. However, some people continue to experience

6975-672: The newly emerging states of the Northwest Territory via the Allegheny & Ohio valleys at Pittsburgh and to Lake Erie — leveraging the wide-ranging branches of the Susquehanna River in the state's center. In the 1830s railway technology and new railroads grew in leaps and bounds, and the Schuylkill Valley was at the heart of these developments, as well as the new Anthracite iron and mining industries. From 1820 to

7068-480: The olfactory epithelium , with subsequent damage to the olfactory neurons . The involvement of both the central and peripheral nervous system in COVID‑19 has been reported in many medical publications. It is clear that many people with COVID-19 exhibit neurological or mental health issues . The virus is not detected in the central nervous system (CNS) of the majority of COVID-19 patients with neurological issues . However, SARS-CoV-2 has been detected at low levels in

7161-488: The peak viral load in upper respiratory tract samples occurs close to the time of symptom onset and declines after the first week after symptoms begin. Current evidence suggests a duration of viral shedding and the period of infectiousness of up to ten days following symptom onset for people with mild to moderate COVID-19, and up to 20 days for persons with severe COVID-19, including immunocompromised people. Severe acute respiratory syndrome coronavirus   2 (SARS-CoV-2)

7254-411: The people who are infected with the virus do not develop noticeable symptoms at any point in time. These asymptomatic carriers tend not to get tested and can still spread the disease. Other infected people will develop symptoms later (called "pre-symptomatic") or have very mild symptoms and can also spread the virus. As is common with infections, there is a delay, or incubation period , between

7347-466: The railroad's profits leading to a widespread collapse of the industry in the 1960s and 1970s. Rail freight still uses many of the same valley rights-of-way that the 19th-century railroads used. Passenger and commuter rail service is more limited. Today, the old rail bed rights-of-way along the river between Philadelphia and Norristown contain SEPTA 's Manayunk/Norristown Line , formerly Reading Railroad and

7440-416: The respiratory tract, people with severe COVID‑19 have symptoms of systemic hyperinflammation. Clinical laboratory findings of elevated IL‑2 , IL‑6 , IL‑7 , as well as the following suggest an underlying immunopathology: Interferon alpha plays a complex, Janus-faced role in the pathogenesis of COVID-19. Although it promotes the elimination of virus-infected cells, it also upregulates

7533-859: The risk of long COVID includes staying up to date on the most recent COVID-19 vaccine, practicing good hygiene, maintaining clean indoor air, and physical distancing from people infected with a respiratory virus. Complications may include pneumonia , acute respiratory distress syndrome (ARDS), multi-organ failure , septic shock , and death. Cardiovascular complications may include heart failure, arrhythmias (including atrial fibrillation ), heart inflammation , thrombosis , particularly venous thromboembolism , and endothelial cell injury and dysfunction. Approximately 20–30% of people who present with COVID‑19 have elevated liver enzymes , reflecting liver injury. Neurologic manifestations include seizure , stroke, encephalitis , and Guillain–Barré syndrome (which includes loss of motor functions ). Following

7626-571: The river has improved much over the past decades. A fish ladder to support shad migration has been constructed at the Manayunk dam. Mayfly hatches (signifying good water quality) now occur yearly along the Montgomery sections of the river. The Schuylkill River valley was an important thoroughfare in the eras of canals and railroads. The river itself, the Schuylkill Canal , the Reading Railroad , and

7719-467: The river in the 19th and 20th centuries. Early concerns over water quality led to the creation of Fairmount Park in 1812. Protections came with the 1972 passing of the Clean Water Act , and the Schuylkill was designated as the first Pennsylvania Scenic River in 1978. Water quality has largely recovered in the years since. The Schuylkill River above Fairmount Dam has been a major rowing venue since

7812-462: The river through the early 20th century. The river was shallow and filled with extensive black silt bars. By the early 20th century, upstream coal operations contributed over 3 million tons of silt annually to the river. In 1948, led by then governor James H. Duff , a massive cleanup effort began. Twenty three impounding basins were excavated along the river, to receive dredged silt. The 1945 Desilting Act helped begin this cleanup task. The quality of

7905-511: The river, including Nittabakonck ("place where heroes reside"), a village on the east bank just south of the confluence of Wissahickon Creek, and the Passyunk site, on the west bank where the Schuylkill meets the Delaware River. > American patriot paper maker Frederick Bicking owned a fishery on the river prior to the American Revolution , and Thomas Paine tried in vain to interest

7998-663: The summer of 2020. As of September 2020, there was still a section of the new railing missing. List of crossings of the Schuylkill River Schuylkill River The river's watershed of about 2,000 sq mi (5,180 km ) lies entirely within the state of Pennsylvania, stretching from the Ridge-and-Valley Appalachians through the Piedmont to the Atlantic Plain . Historically

8091-527: The urban Schuylkill River in the 21st century. In several episodes of Cold Case , a CBS television series based on the Philadelphia Police Department that aired from 2003 to 2010, various members of the Cold Case squad mention finding "a floater in the Schuylkill". In the 2019 film The Irishman , mob hitman Frank Sheeran , played by Robert De Niro , disposes of a gun he just used in

8184-458: The village of Mont Clare , the latter of which are the locations of the last two remaining watered stretches of the Schuylkill Canal . There is also a section of trail starting at Pottstown and running upriver toward Reading. Plans are under way to complete the trail from the Delaware River to Reading. Jules Verne 's 1904 novel Robur the Conqueror starts out in Philadelphia on the banks of

8277-507: The virus acting through ACE2-related entry into lymphocytes. Another common cause of death is complications related to the kidneys . Early reports show that up to 30% of hospitalised patients both in China and in New York have experienced some injury to their kidneys, including some persons with no previous kidney problems. Although SARS-CoV-2 has a tropism for ACE2-expressing epithelial cells of

8370-752: The virus even if they do not develop symptoms. Testing methods for COVID-19 to detect the virus's nucleic acid include real-time reverse transcription polymerase chain reaction (RT‑PCR), transcription-mediated amplification , and reverse transcription loop-mediated isothermal amplification (RT‑LAMP) from a nasopharyngeal swab . Several COVID-19 vaccines have been approved and distributed in various countries, many of which have initiated mass vaccination campaigns . Other preventive measures include physical or social distancing , quarantining , ventilation of indoor spaces, use of face masks or coverings in public, covering coughs and sneezes, hand washing , and keeping unwashed hands away from

8463-509: The virus is carried out through virus-laden fluid particles, or droplets, which are created in the respiratory tract, and they are expelled by the mouth and the nose. There are three types of transmission: "droplet" and "contact", which are associated with large droplets, and "airborne", which is associated with small droplets. If the droplets are above a certain critical size, they settle faster than they evaporate , and therefore they contaminate surfaces surrounding them. Droplets that are below

8556-500: Was Ganshowe-hánne , meaning "roaring stream". The river was also sometimes called the Manaiunk in European sources, which derives from a Lenape place-name meaning "place to drink". This name appears on a Swedish map of 1655 in the form Menejackse Kÿl . The mighty Susquehannock confederation claimed the area along the Schuylkill as a hunting ground, as they did to the lands down along

8649-535: Was built on piles, just down stream from the previous, until the permanent replacement could be built. In December 1915, the County Commissioners of Montgomery and Chester Counties requested sealed bids for a five span, concrete arch bridge. In 1916 construction started on the new bridge, which was completed in April 1917. The 1916 bridge was designed by B. H. Davis and constructed by Ambler-Davis Co. Each of

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