Beatrice Mintz (January 24, 1921 – January 3, 2022) was an American embryologist who contributed to the understanding of genetic modification , cellular differentiation , and cancer, particularly melanoma . Mintz was a pioneer of genetic engineering techniques and was among the first scientists to generate both chimeric and transgenic mammals.
16-911: Mintz is a Jewish (Ashkenazic) surname of German origin. Its etymology may be connected to the German city of Mainz. Notable people with the surname include: Beatrice Mintz (1921–2022), American embryologist Binyamin Mintz (1903–1961), Israeli politician Charles Mintz (1896–1940), American film producer and distributor Christopher Mintz-Plasse (born 1989), American actor, comedian and musician Dan Mintz (born 1981), American actor and comedian Dan Mintz (executive) (boen 1965), American filmmaker, producer and businessman David Mintz (disambiguation) , multiple people Elliot Mintz (born 1945), American consultant Grafton K. Mintz (1925–1983), American writer and translator Humphrey Mintz , fictional character in
32-639: A Fulbright research fellowship at the universities of Paris and Strasbourg in 1951). In 1960 she moved to the Institute for Cancer Research of the Lankenau Hospital Research Institute, which became the Fox Chase Cancer Center in 1974, where she remained on faculty. In the mid-1950s, Mintz switched her research focus from amphibians to mammals and became a pioneer in mammalian transgenesis . In 1965, she became an adjunct professor at
48-545: A healthy mouse when combined with normal mouse embryo cells through eight years of experiments using some of the first pluripotent stem cell cultures ever made. Mintz and Rudolf Jaenisch published a technological breakthrough in 1974. Jaenisch was a post-doctoral researcher at Princeton University at the time. He was interested in why only certain types of cancer occurred when he injected adult mice with viruses. Inspired by Mintz's earlier work, he wanted to know whether injecting virus into early-stage embryos would result in
64-711: A member of both the United States National Academy of Sciences and the Pontifical Academy of Sciences . Beatrice Mintz was born in New York City on January 24, 1921, to Samuel and Janie Stein Mintz, a Jewish couple from Mikulintsy , then in Austrian Galicia , now in Ukraine . She was graduated magna cum laude from Hunter College in 1941 and then took graduate studies at New York University for
80-640: A technique that involved mixing cells from a black mouse strain into the blastocysts of white or brown mice in vitro . She then surgically transferred these early embryos into surrogate mothers and, after birth, traced the tissue contribution of each cell type made by studying the coat color. Her cell fusion technique was successful where others had failed due to the choice to remove the zona pellucida with pronase treatment, rather than physically. Since 1967 Mintz has created more than 25,000 offspring using this technique. Mintz demonstrated that teratocarcinoma tumor cells could be reprogrammed to contribute to
96-455: A year. Because of anti-Semitic quotas for admission to colleges on the east coast, she attended the University of Iowa , where she received a master's degree in 1944 and her Ph.D. in 1946, studying amphibians under Emil Witschi. After graduation, Mintz accepted a professorship in biological science at the University of Chicago (1946–60; interrupted by studies abroad: Mintz was awarded
112-638: Is different from Wikidata All set index articles Beatrice Mintz In 1996, she shared the inaugural March of Dimes Prize in Developmental Biology with Ralph L. Brinster for their work in developing transgenic mice. Much of her career was spent at Fox Chase Cancer Center in Philadelphia where, in 2002, she was appointed to the Jack Schultz Chair in Basic Science. Mintz was
128-1491: The Suikoden role playing games Jordan Mintz , former vice president and General Counsel for Corporate Development at Enron Corporation Joshua Mintz (born 1965), Mexican TV executive Morton Mintz (born 1922), American investigative journalist Noah Mintz (born 1970), Canadian musician Sam Mintz (1897–1957), American screenwriter Shlomo Mintz (born 1957), Israeli violin virtuoso, violist and conductor Sidney Mintz (1922–2015), American anthropologist Tanhum Cohen-Mintz (1939–2014), Latvian-born Israeli basketball player Uri Cohen-Mintz (born 1973), Israeli basketball player Mints [ edit ] Lloyd Mints (1888–1989), American economist Zara Mints (1927–1990), Jewish Russian philologist Minc [ edit ] Hilary Minc (1905–1974), Polish economist and politician See also [ edit ] Mintz, Levin, Cohn, Ferris, Glovsky, and Popeo , fourth largest law firm in Massachusetts by number of attorneys Minz Mentz (disambiguation) Munz Muntz References [ edit ] ^ Hanks, Patrick; Lenarčič, Simon; McClure, Peter (August 2022). "Dictionary of American Family Names" . Oxford Reference . Retrieved 10 November 2024 . {{ cite web }} : CS1 maint: url-status ( link ) [REDACTED] Surname list This page lists people with
144-439: The University of Pennsylvania . Mintz and Andrzej K. Tarkowski independently made the first mouse embryonic chimeras in the 1960s by aggregating two embryos at the eight-cell stage. The resultant mice developed normally and their tissues were a mixture of cells derived from the two donor embryos. Mintz went on to create viable chimeric embryos containing blastomeres from up to fifteen different laboratory mice. She developed
160-554: The surname Mintz . If an internal link intending to refer to a specific person led you to this page, you may wish to change that link by adding the person's given name (s) to the link. Retrieved from " https://en.wikipedia.org/w/index.php?title=Mintz&oldid=1256767052 " Categories : Surnames Surnames of Jewish origin Germanic-language surnames Hidden categories: CS1 maint: url-status Articles with short description Short description
176-1027: The Amory Prize (1988), the Ernst Jung Gold Medal for Medicine (1990), the John Scott Medal (1994), the American Cancer Society National Medal of Honor for Basic Research (1997), a citation for Outstanding Woman in Science (1993) from the New York Academy of Sciences, and, in 2007, was a recipient of the Pearl Meister Greengard Prize . On March 8, 2011, the U.S. National Foundation for Cancer Research awarded Beatrice Mintz its Sixth Annual Szent-Gyorgyi Prize for Progress in Cancer Research. In 2012, Mintz
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#1732859502087192-482: The DNA being incorporated, and what types of cancer would occur. Mintz agreed to work with Jaenisch, who joined her lab as a visiting fellow for nine months. They showed that DNA from a virus, SV40 , could be integrated into the DNA of developing mice and persist into adulthood without apparent tumor formation. Although only somatic cells were affected, meaning the DNA would not be passed on to future generations, these were
208-758: The first March of Dimes Prize in Developmental Biology shared with Ralph L. Brinster (1996). She was elected a fellow of the American Academy of Arts and Sciences (1982), American Association for the Advancement of Science (1973), the American Philosophical Society (1982), and won an honorary fellow of the American Gynecological and Obstetrical Society since 1980. She won the Papanicolaou Award for Scientific Achievement (1979),
224-437: The first mice ever made with foreign DNA and this experiment proved healthy genetically modified mammals could be created by viral infection. Using these techniques Mintz was able to establish the genetic basis of certain kinds of cancer and, in 1993, she produced the first mouse model of human malignant melanoma . Mintz received numerous awards and honors including the first Genetics Society of America Medal (1981), and
240-574: Was a member of the National Academy of Sciences, a senior member of the Institute for Cancer Research , Fox Chase Cancer Center in Philadelphia, and served on the editorial boards of various scientific journals. Mintz died on January 3, 2022, from heart failure, at age 100. She had dementia in her later years. March of Dimes Prize in Developmental Biology Too Many Requests If you report this error to
256-747: Was awarded the Ninth Annual AACR Award for Lifetime Achievement in Cancer Research . She received honorary doctorate degrees from five universities. She delivered dozens of special lectures, including the Ninetieth Anniversary Lecture at the Woods Hole Marine Biological Laboratory (1978) and the first Frontiers in Biomedical Sciences Lecture at the New York Academy of Sciences (1980). She
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