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MELD-Plus is a risk score to assess severity of chronic liver disease that was resulted from a collaboration between Massachusetts General Hospital and IBM . The score includes nine variables as effective predictors for 90-day mortality after a discharge from a cirrhosis-related admission. The variables include all Model for End-Stage Liver Disease (MELD)'s components, as well as sodium, albumin, total cholesterol, white blood cell count, age, and length of stay.

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59-470: Because total cholesterol and hospital length of stay are typically not uniform factors across different hospitals and may vary in different countries, an additional model that included only seven of the nine variables was evaluated. This yielded a performance close to the one of using all nine variables and resulted in the following associations with increased mortality: INR, creatinine, total bilirubin, sodium, WBC, albumin, and age. The development of MELD-Plus

118-400: A search algorithm to search through the space of possible features and evaluate each subset by running a model on the subset. Wrappers can be computationally expensive and have a risk of over fitting to the model. Filters are similar to wrappers in the search approach, but instead of evaluating against a model, a simpler filter is evaluated. Embedded techniques are embedded in, and specific to,

177-520: A candidate feature (or set of features) and the desired output category. There are, however, true metrics that are a simple function of the mutual information; see here . Other available filter metrics include: The choice of optimality criteria is difficult as there are multiple objectives in a feature selection task. Many common criteria incorporate a measure of accuracy, penalised by the number of features selected. Examples include Akaike information criterion (AIC) and Mallows's C p , which have

236-582: A feature vector. One way to achieve binary classification is using a linear predictor function (related to the perceptron ) with a feature vector as input. The method consists of calculating the scalar product between the feature vector and a vector of weights, qualifying those observations whose result exceeds a threshold. Algorithms for classification from a feature vector include nearest neighbor classification , neural networks , and statistical techniques such as Bayesian approaches . In character recognition , features may include histograms counting

295-649: A global quadratic programming optimization problem as follows: where F n × 1 = [ I ( f 1 ; c ) , … , I ( f n ; c ) ] T {\displaystyle F_{n\times 1}=[I(f_{1};c),\ldots ,I(f_{n};c)]^{T}} is the vector of feature relevancy assuming there are n features in total, H n × n = [ I ( f i ; f j ) ] i , j = 1 … n {\displaystyle H_{n\times n}=[I(f_{i};f_{j})]_{i,j=1\ldots n}}

354-439: A global optimum. There are many metaheuristics, from a simple local search to a complex global search algorithm. The feature selection methods are typically presented in three classes based on how they combine the selection algorithm and the model building. Filter type methods select variables regardless of the model. They are based only on general features like the correlation with the variable to predict. Filter methods suppress

413-414: A model. Many popular search approaches use greedy hill climbing , which iteratively evaluates a candidate subset of features, then modifies the subset and evaluates if the new subset is an improvement over the old. Evaluation of the subsets requires a scoring metric that grades a subset of features. Exhaustive search is generally impractical, so at some implementor (or operator) defined stopping point,

472-676: A penalty of 2 for each added feature. AIC is based on information theory , and is effectively derived via the maximum entropy principle . Other criteria are Bayesian information criterion (BIC), which uses a penalty of log ⁡ n {\displaystyle {\sqrt {\log {n}}}} for each added feature, minimum description length (MDL) which asymptotically uses log ⁡ n {\displaystyle {\sqrt {\log {n}}}} , Bonferroni / RIC which use 2 log ⁡ p {\displaystyle {\sqrt {2\log {p}}}} , maximum dependency feature selection, and

531-665: A phenomenon. Choosing informative, discriminating, and independent features is crucial to produce effective algorithms for pattern recognition , classification , and regression tasks. Features are usually numeric, but other types such as strings and graphs are used in syntactic pattern recognition , after some pre-processing step such as one-hot encoding . The concept of "features" is related to that of explanatory variables used in statistical techniques such as linear regression . In feature engineering, two types of features are commonly used: numerical and categorical. Numerical features are continuous values that can be measured on

590-458: A scale. Examples of numerical features include age, height, weight, and income. Numerical features can be used in machine learning algorithms directly. Categorical features are discrete values that can be grouped into categories. Examples of categorical features include gender, color, and zip code. Categorical features typically need to be converted to numerical features before they can be used in machine learning algorithms. This can be done using

649-504: A variable similar to the variables selected at previous tree nodes for splitting the current node. Regularized trees only need build one tree model (or one tree ensemble model) and thus are computationally efficient. Regularized trees naturally handle numerical and categorical features, interactions and nonlinearities. They are invariant to attribute scales (units) and insensitive to outliers , and thus, require little data preprocessing such as normalization . Regularized random forest (RRF)

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708-455: A variety of new criteria that are motivated by false discovery rate (FDR), which use something close to 2 log ⁡ p q {\displaystyle {\sqrt {2\log {\frac {p}{q}}}}} . A maximum entropy rate criterion may also be used to select the most relevant subset of features. Filter feature selection is a specific case of a more general paradigm called structure learning . Feature selection finds

767-478: A variety of techniques, such as one-hot encoding, label encoding, and ordinal encoding. The type of feature that is used in feature engineering depends on the specific machine learning algorithm that is being used. Some machine learning algorithms, such as decision trees, can handle both numerical and categorical features. Other machine learning algorithms, such as linear regression, can only handle numerical features. A numeric feature can be conveniently described by

826-501: A “trough of disillusionment” by fostering a stronger appreciation of the technology's capabilities and limitations." However, the authors further added "Although predictive algorithms cannot eliminate medical uncertainty, they already improve allocation of scarce health care resources, helping to avert hospitalization for patients with low-risk pulmonary embolisms (PESI) and fairly prioritizing patients for liver transplantation by means of MELD scores." A sample code for calculating MELD-Plus

885-1644: Is a kernel-based independence measure called the (empirical) Hilbert-Schmidt independence criterion (HSIC), tr ( ⋅ ) {\displaystyle {\mbox{tr}}(\cdot )} denotes the trace , λ {\displaystyle \lambda } is the regularization parameter, K ¯ ( k ) = Γ K ( k ) Γ {\displaystyle {\bar {\mathbf {K} }}^{(k)}=\mathbf {\Gamma } \mathbf {K} ^{(k)}\mathbf {\Gamma } } and L ¯ = Γ L Γ {\displaystyle {\bar {\mathbf {L} }}=\mathbf {\Gamma } \mathbf {L} \mathbf {\Gamma } } are input and output centered Gram matrices , K i , j ( k ) = K ( u k , i , u k , j ) {\displaystyle K_{i,j}^{(k)}=K(u_{k,i},u_{k,j})} and L i , j = L ( c i , c j ) {\displaystyle L_{i,j}=L(c_{i},c_{j})} are Gram matrices, K ( u , u ′ ) {\displaystyle K(u,u')} and L ( c , c ′ ) {\displaystyle L(c,c')} are kernel functions, Γ = I m − 1 m 1 m 1 m T {\displaystyle \mathbf {\Gamma } =\mathbf {I} _{m}-{\frac {1}{m}}\mathbf {1} _{m}\mathbf {1} _{m}^{T}}

944-450: Is an approximation of the theoretically optimal maximum-dependency feature selection algorithm that maximizes the mutual information between the joint distribution of the selected features and the classification variable. As mRMR approximates the combinatorial estimation problem with a series of much smaller problems, each of which only involves two variables, it thus uses pairwise joint probabilities which are more robust. In certain situations

1003-617: Is available in GitHub . Feature selection In machine learning, feature selection is the process of selecting a subset of relevant features (variables, predictors) for use in model construction. Feature selection techniques are used for several reasons: The central premise when using feature selection is that data sometimes contains features that are redundant or irrelevant , and can thus be removed without incurring much loss of information. Redundancy and irrelevance are two distinct notions, since one relevant feature may be redundant in

1062-521: Is available. Calculators capable of calculating MELD and MELD-Na are available. Johnson HR. Developing a new score: how machine learning improves risk prediction. Livernois C. Harvard researchers develop predictive model for cirrhosis outcomes. Goedert J. IBM taps machine learning to predict cirrhosis mortality rates. Cohen JK. Harvard, IBM researchers develop prediction model for cirrhosis outcomes. Massachusetts General Hospital (Snapshot of Science). A call for an additional validation of MELD-Plus

1121-479: Is deciding when to stop the algorithm. In machine learning, this is typically done by cross-validation . In statistics, some criteria are optimized. This leads to the inherent problem of nesting. More robust methods have been explored, such as branch and bound and piecewise linear network. Subset selection evaluates a subset of features as a group for suitability. Subset selection algorithms can be broken up into wrappers, filters, and embedded methods. Wrappers use

1180-531: Is defined as follows: The r c f i {\displaystyle r_{cf_{i}}} and r f i f j {\displaystyle r_{f_{i}f_{j}}} variables are referred to as correlations, but are not necessarily Pearson's correlation coefficient or Spearman's ρ . Hall's dissertation uses neither of these, but uses three different measures of relatedness, minimum description length (MDL), symmetrical uncertainty , and relief . Let x i be

1239-487: Is formulated as follows: The score uses the conditional mutual information and the mutual information to estimate the redundancy between the already selected features ( f j ∈ S {\displaystyle f_{j}\in S} ) and the feature under investigation ( f i {\displaystyle f_{i}} ). For high-dimensional and small sample data (e.g., dimensionality > 10 and

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1298-407: Is made difficult or ineffective. Therefore, a preliminary step in many applications of machine learning and pattern recognition consists of selecting a subset of features, or constructing a new and reduced set of features to facilitate learning, and to improve generalization and interpretability. Extracting or selecting features is a combination of art and science; developing systems to do so

1357-401: Is one type of regularized trees. The guided RRF is an enhanced RRF which is guided by the importance scores from an ordinary random forest. A metaheuristic is a general description of an algorithm dedicated to solve difficult (typically NP-hard problem) optimization problems for which there is no classical solving methods. Generally, a metaheuristic is a stochastic algorithm tending to reach

1416-531: Is projected to save 50–60 lives total per year. Furthermore, a study published in the New England Journal of Medicine in 2008, estimated that using MELD-Na instead of MELD would save 90 lives for the period from 2005 to 2006. In his viewpoint published in June 2018, co-creator of MELD-Plus, Uri Kartoun, suggested that "...MELD-Plus, if incorporated into hospital systems, could save hundreds of patients every year in

1475-437: Is that it can be solved simply via finding the dominant eigenvector of Q , thus is very scalable. SPEC CMI also handles second-order feature interaction. In a study of different scores Brown et al. recommended the joint mutual information as a good score for feature selection. The score tries to find the feature, that adds the most new information to the already selected features, in order to avoid redundancy. The score

1534-471: Is the ℓ 1 {\displaystyle \ell _{1}} -norm. HSIC always takes a non-negative value, and is zero if and only if two random variables are statistically independent when a universal reproducing kernel such as the Gaussian kernel is used. The HSIC Lasso can be written as where ‖ ⋅ ‖ F {\displaystyle \|\cdot \|_{F}}

1593-511: Is the Frobenius norm . The optimization problem is a Lasso problem, and thus it can be efficiently solved with a state-of-the-art Lasso solver such as the dual augmented Lagrangian method . The correlation feature selection (CFS) measure evaluates subsets of features on the basis of the following hypothesis: "Good feature subsets contain features highly correlated with the classification, yet uncorrelated to each other". The following equation gives

1652-477: Is the Markov blanket of the target node, and in a Bayesian Network, there is a unique Markov Blanket for each node. There are different Feature Selection mechanisms around that utilize mutual information for scoring the different features. They usually use all the same algorithm: The simplest approach uses the mutual information as the "derived" score. However, there are different approaches, that try to reduce

1711-399: Is the centering matrix, I m {\displaystyle \mathbf {I} _{m}} is the m -dimensional identity matrix ( m : the number of samples), 1 m {\displaystyle \mathbf {1} _{m}} is the m -dimensional vector with all ones, and ‖ ⋅ ‖ 1 {\displaystyle \|\cdot \|_{1}}

1770-483: Is the matrix of feature pairwise redundancy, and x n × 1 {\displaystyle \mathbf {x} _{n\times 1}} represents relative feature weights. QPFS is solved via quadratic programming. It is recently shown that QFPS is biased towards features with smaller entropy, due to its placement of the feature self redundancy term I ( f i ; f i ) {\displaystyle I(f_{i};f_{i})} on

1829-412: Is used to determine a score for making a prediction. The vector space associated with these vectors is often called the feature space . In order to reduce the dimensionality of the feature space, a number of dimensionality reduction techniques can be employed. Higher-level features can be obtained from already available features and added to the feature vector; for example, for the study of diseases

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1888-492: The FRMT algorithm. This is a survey of the application of feature selection metaheuristics lately used in the literature. This survey was realized by J. Hammon in her 2013 thesis. Some learning algorithms perform feature selection as part of their overall operation. These include: Feature (machine learning) In machine learning and pattern recognition , a feature is an individual measurable property or characteristic of

1947-575: The Fast Correlation Based Filter (FCBF) algorithm. Wrapper methods evaluate subsets of variables which allows, unlike filter approaches, to detect the possible interactions amongst variables. The two main disadvantages of these methods are: Embedded methods have been recently proposed that try to combine the advantages of both previous methods. A learning algorithm takes advantage of its own variable selection process and performs feature selection and classification simultaneously, such as

2006-701: The United States alone." A review specifying alternatives to MELD, including MELD-Na, MELD-sarcopenia, UKELD, D-MELD, iMELD, and MELD-Plus, was published in June 2019 in Seminars in Liver Disease. The optimized prediction of mortality (OPOM) score is another tool that has been proposed to serve as an alternative to Model for End-Stage Liver Disease . A review published in Transplantation in February 2020 highlighted

2065-427: The algorithm may underestimate the usefulness of features as it has no way to measure interactions between features which can increase relevancy. This can lead to poor performance when the features are individually useless, but are useful when combined (a pathological case is found when the class is a parity function of the features). Overall the algorithm is more efficient (in terms of the amount of data required) than

2124-439: The algorithm, and it is these evaluation metrics which distinguish between the three main categories of feature selection algorithms: wrappers, filters and embedded methods. In traditional regression analysis , the most popular form of feature selection is stepwise regression , which is a wrapper technique. It is a greedy algorithm that adds the best feature (or deletes the worst feature) at each round. The main control issue

2183-648: The array operators {max(S), min(S), average(S)} as well as other more sophisticated operators, for example count(S,C) that counts the number of features in the feature vector S satisfying some condition C or, for example, distances to other recognition classes generalized by some accepting device. Feature construction has long been considered a powerful tool for increasing both accuracy and understanding of structure, particularly in high-dimensional problems. Applications include studies of disease and emotion recognition from speech. The initial set of raw features can be redundant and large enough that estimation and optimization

2242-435: The combination of a search technique for proposing new feature subsets, along with an evaluation measure which scores the different feature subsets. The simplest algorithm is to test each possible subset of features finding the one which minimizes the error rate. This is an exhaustive search of the space, and is computationally intractable for all but the smallest of feature sets. The choice of evaluation metric heavily influences

2301-517: The data that score highly: the features that have the largest projections in the lower-dimensional space are then selected. Search approaches include: Two popular filter metrics for classification problems are correlation and mutual information , although neither are true metrics or 'distance measures' in the mathematical sense, since they fail to obey the triangle inequality and thus do not compute any actual 'distance' – they should rather be regarded as 'scores'. These scores are computed between

2360-599: The diagonal of H . Another score derived for the mutual information is based on the conditional relevancy: where Q i i = I ( f i ; c ) {\displaystyle Q_{ii}=I(f_{i};c)} and Q i j = ( I ( f i ; c | f j ) + I ( f j ; c | f i ) ) / 2 , i ≠ j {\displaystyle Q_{ij}=(I(f_{i};c|f_{j})+I(f_{j};c|f_{i}))/2,i\neq j} . An advantage of SPEC CMI

2419-414: The feature f i in the globally optimal feature set. Let c i = I ( f i ; c ) {\displaystyle c_{i}=I(f_{i};c)} and a i j = I ( f i ; f j ) {\displaystyle a_{ij}=I(f_{i};f_{j})} . The above may then be written as an optimization problem: The mRMR algorithm

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2478-428: The feature 'Age' is useful and is defined as Age = 'Year of death' minus 'Year of birth' . This process is referred to as feature construction . Feature construction is the application of a set of constructive operators to a set of existing features resulting in construction of new features. Examples of such constructive operators include checking for the equality conditions {=, ≠}, the arithmetic operators {+,−,×, /},

2537-425: The feature values might correspond to the pixels of an image, while when representing texts the features might be the frequencies of occurrence of textual terms. Feature vectors are equivalent to the vectors of explanatory variables used in statistical procedures such as linear regression . Feature vectors are often combined with weights using a dot product in order to construct a linear predictor function that

2596-418: The importance of incorporating machine-learning techniques into liver-related prediction tools, especially within the context of the limited accuracy of MELD-Na when applied to patients with low scores. Transplantation further published a correspondence emphasizing this point. Chen & Asch 2017 wrote: "With machine learning situated at the peak of inflated expectations, we can soften a subsequent crash into

2655-588: The increased accuracy of using MELD-Plus vs. MELD in predicting early acute kidney injury after liver transplantation . MELD-Plus was validated by using Explorys. MELD-Plus was proposed as advantageous for patients with low MELD-Na scores. MELD 3.0 was introduced in 2021. A comparison between MELD 3.0, MELD-Plus, and other risk assessment scores in liver proposes approaches to more optimally allocate livers. United Network for Organ Sharing proposed that MELD-Na score (an extension of MELD) may better rank candidates based on their risk of pre-transplant mortality and

2714-525: The individual feature f i and the class c as follows: The redundancy of all features in the set S is the average value of all mutual information values between the feature f i and the feature f j : The mRMR criterion is a combination of two measures given above and is defined as follows: Suppose that there are n full-set features. Let x i be the set membership indicator function for feature f i , so that x i =1 indicates presence and x i =0 indicates absence of

2773-522: The language, the frequency of specific terms, the grammatical correctness of the text. In computer vision , there are a large number of possible features , such as edges and objects. In pattern recognition and machine learning , a feature vector is an n-dimensional vector of numerical features that represent some object. Many algorithms in machine learning require a numerical representation of objects, since such representations facilitate processing and statistical analysis. When representing images,

2832-473: The least interesting variables. The other variables will be part of a classification or a regression model used to classify or to predict data. These methods are particularly effective in computation time and robust to overfitting. Filter methods tend to select redundant variables when they do not consider the relationships between variables. However, more elaborate features try to minimize this problem by removing variables highly correlated to each other, such as

2891-422: The merit of a feature subset S consisting of k features: Here, r c f ¯ {\displaystyle {\overline {r_{cf}}}} is the average value of all feature-classification correlations, and r f f ¯ {\displaystyle {\overline {r_{ff}}}} is the average value of all feature-feature correlations. The CFS criterion

2950-410: The number of black pixels along horizontal and vertical directions, number of internal holes, stroke detection and many others. In speech recognition , features for recognizing phonemes can include noise ratios, length of sounds, relative power, filter matches and many others. In spam detection algorithms, features may include the presence or absence of certain email headers, the email structure,

3009-535: The number of samples < 10 ), the Hilbert-Schmidt Independence Criterion Lasso (HSIC Lasso) is useful. HSIC Lasso optimization problem is given as where HSIC ( f k , c ) = tr ( K ¯ ( k ) L ¯ ) {\displaystyle {\mbox{HSIC}}(f_{k},c)={\mbox{tr}}({\bar {\mathbf {K} }}^{(k)}{\bar {\mathbf {L} }})}

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3068-399: The presence of another relevant feature with which it is strongly correlated. Feature extraction creates new features from functions of the original features, whereas feature selection finds a subset of the features. Feature selection techniques are often used in domains where there are many features and comparatively few samples (data points). A feature selection algorithm can be seen as

3127-425: The redundancy between features. Peng et al. proposed a feature selection method that can use either mutual information, correlation, or distance/similarity scores to select features. The aim is to penalise a feature's relevancy by its redundancy in the presence of the other selected features. The relevance of a feature set S for the class c is defined by the average value of all mutual information values between

3186-404: The relevant feature set for a specific target variable whereas structure learning finds the relationships between all the variables, usually by expressing these relationships as a graph. The most common structure learning algorithms assume the data is generated by a Bayesian Network , and so the structure is a directed graphical model . The optimal solution to the filter feature selection problem

3245-472: The set membership indicator function for feature f i ; then the above can be rewritten as an optimization problem: The combinatorial problems above are, in fact, mixed 0–1 linear programming problems that can be solved by using branch-and-bound algorithms . The features from a decision tree or a tree ensemble are shown to be redundant. A recent method called regularized tree can be used for feature subset selection. Regularized trees penalize using

3304-415: The subset of features with the highest score discovered up to that point is selected as the satisfactory feature subset. The stopping criterion varies by algorithm; possible criteria include: a subset score exceeds a threshold, a program's maximum allowed run time has been surpassed, etc. Alternative search-based techniques are based on targeted projection pursuit which finds low-dimensional projections of

3363-509: The theoretically optimal max-dependency selection, yet produces a feature set with little pairwise redundancy. mRMR is an instance of a large class of filter methods which trade off between relevancy and redundancy in different ways. mRMR is a typical example of an incremental greedy strategy for feature selection: once a feature has been selected, it cannot be deselected at a later stage. While mRMR could be optimized using floating search to reduce some features, it might also be reformulated as

3422-477: Was based on using unbiased approach toward discovery of biomarkers. In this approach, a feature selection machine learning algorithm observes a large collection of health records and identifies a small set of variables that could serve as the most efficient predictors for a given medical outcome. An example for a notable feature selection method is lasso (least absolute shrinkage and selection operator). A calculator capable of comparing MELD, MELD-Na, and MELD-Plus

3481-687: Was published in November 2019 in the European Journal of Gastroenterology & Hepatology . A study presented in June 2019 in Semana Digestiva (Vilamoura, Portugal) demonstrated that MELD-Plus was superior to assess mortality at 180 days vs. other liver-related scores in a population admitted due to hepatic encephalopathy . A study published in April 2018 in Surgery, Gastroenterology and Oncology reported on

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