9-650: MAFB can refer to: MAFB , a human gene that encodes the MafB transcription factor March Joint Air Reserve Base (March Air Force Base) Maxwell Air Force Base in Montgomery, Alabama Minot Air Force Base in Minot, North Dakota Moody Air Force Base in Valdosta, Georgia Topics referred to by the same term [REDACTED] This disambiguation page lists articles associated with
18-740: A genomewide association study involving 1,908 case-parent trios from Europe, the United States, China, Taiwan, Singapore, Korea, and the Philippines, first identified MAFB as being associated with cleft lip and/or palate with stronger genome-wide significance in Asian than European populations. The difference in populations could reflect variable coverage by available markers or true allelic heterogeneity. In mouse models, Mafb mRNA and protein were detected in both craniofacial ectoderm and neural crest-derived mesoderm between embryonic days 13.5 and 14.5; expression
27-486: Is a protein that in humans is encoded by the MAFB gene . This gene maps to chromosome 20q 11.2-q13.1, consists of a single exon and spans around 3 kb. MafB is a basic leucine zipper ( bZIP ) transcription factor that plays an important role in the regulation of lineage-specific hematopoiesis . The encoded nuclear protein represses ETS1 -mediated transcription of erythroid-specific genes in myeloid cells. Mutations in
36-450: The null hypothesis of no true SNP-association will typically be rejected. However, there has been some criticism of this threshold, with a 2012 study suggesting that a significant number of associations with p -values just above this threshold are genuine, replicable associations. The authors of this study concluded that their finding "...suggests a possible relaxation in the current GWS threshold." More recently, it has been suggested that
45-406: The statistical significance of a reported association between a given single-nucleotide polymorphism (SNP) and a given trait . The most commonly accepted threshold is p < 5 × 10 , which is based on performing a Bonferroni correction for all the independent common SNPs across the human genome . If a p -value is found to be lower than this threshold in a genome-wide association study,
54-528: The MAFB gene include numerous binding sites for transcription factors that are known to have a role in palate development. This article incorporates text from the United States National Library of Medicine , which is in the public domain . Genome-wide significance In genome-wide association studies , genome-wide significance (abbreviated GWS ) is a specific threshold for determining
63-521: The murine Mafb gene are responsible for the mutant mouse Kreisler (kr) that presents an abnormal segmentation of the hindbrain and exhibit hyperactive behavior, including head tossing and running in circles. This mice dies at birth due to renal failure whereas the Mafb -/- mice dies of central apnea. Recently, single-nucleotide polymorphisms (SNPs) near MAFB have been found associated with nonsyndromic cleft lip and palate . The GENEVA Cleft Consortium study,
72-713: The title MAFB . If an internal link led you here, you may wish to change the link to point directly to the intended article. Retrieved from " https://en.wikipedia.org/w/index.php?title=MAFB&oldid=638045554 " Category : Disambiguation pages Hidden categories: Short description is different from Wikidata All article disambiguation pages All disambiguation pages MAFB (gene) 2WT7 , 2WTY , 4AUW 9935 16658 ENSG00000204103 ENSMUSG00000074622 Q9Y5Q3 P54841 NM_005461 NM_010658 NP_005452 NP_034788 Transcription factor MafB also known as V-maf musculoaponeurotic fibrosarcoma oncogene homolog B
81-471: Was strong in the epithelium around the palatal shelves and in the medial edge epithelium during palatal fusion. After fusion, Mafb expression was stronger in oral epithelium compared to mesenchymal tissue. In addition, sequencing analysis detected a new missense mutation in the Filipino population, H131Q, that was significantly more frequent in cases than in matched controls. The gene-poor regions either side of
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