Lonza Group AG is a Swiss multinational manufacturing company for the pharmaceutical , biotechnology and nutrition sectors, headquartered in Basel , with major facilities in Europe , North America and South Asia. Lonza was established under that name in the late 19th-century in Switzerland. The company provides product development services to the pharmaceutical and biologic industries, including custom manufacturing of biopharmaceuticals and detection systems and services for the bioscience sector.
21-574: Lonza may refer to: Lonza Group , a Swiss company Lonza Bowdler (1901–1962), Welsh rugby union player Tonko Lonza (1930–2018), Croatian actor Cured pork tenderloin (Italian: Lonza stagionata ) Lonza, a river that runs through the Lötschental valley in Valais, Switzerland Lonza , a swift spotted beast in Dante's Inferno Topics referred to by
42-437: A cheap nitrogenous fertilisers , only to be supplanted by urea. Several new processes were launched in the 1920s. In addition to an electrolysis plant capable of making 5800 m hydrogen per hour, came metaldehyde, ammonia and ketene. In 1923, Lonza started to convert calcium carbide to metaldehyde (sold as a solid fuel under the brand 'Meta' and then slug repellant) via acetylene and acetaldehyde. In 1925, ammonia production
63-622: A new facility dedicated to Alexion manufacturing. In 2017, Lonza and Sanofi partnered to construct a new facility for production of biologics. In May 2020, Moderna struck a manufacturing deal with Lonza to produce its (mRNA-1273) COVID-19 vaccine active ingredient while expanding sterile production and fill-finish activities to 500 million doses starting in 2021. Production of the mRNA bulk vaccine started in January 2021, soon after an official visit by Swiss Federal Councilor Alain Berset . Lonza Group
84-418: A partnership with Teva in 2009 to develop and manufacture biosimilars. In 2010, they made a deal with GlaxoSmithKline to manufacture therapeutic monoclonal antibodies . In 2014, Lonza entered into an agreement with Bristol-Myers Squibb to manufacture two biologic drugs. Lonza also manufactures Imbruvica for Pharmacyclics and Mydicar for Celladon . In 2015, Lonza contracted with Alexion to construct
105-442: Is an organic compound with the molecular formula C 4 H 4 O 2 , and which is sometimes written as (CH 2 CO) 2 . It is formed by dimerization of ketene , H 2 C=C=O . Diketene is a member of the oxetane family. It is used as a reagent in organic chemistry . It is a colorless liquid. Diketene is produced on commercial scale by dimerization of ketene . Heating or irradiation with UV light regenerates
126-461: Is different from Wikidata All article disambiguation pages All disambiguation pages Lonza Group Lonza was founded in 1897 in the small Swiss town of Gampel , situated in the canton of Valais , taking its name from the nearby river . In the course of the 20th century Lonza evolved from hydroelectricity and C2 chemistry, through nitrogen chemistry to petrochemistry before moving into fine chemistry and biochemistry. Initially,
147-655: Is one of four sites which are focused on cell and gene therapy, the other three being in Portsmouth, New Hampshire ; Geleen, Netherlands ; and Singapore. In October 2024, the company completed the acquisition of the Genentech biologics manufacturing site in Vacaville, California , from Roche. As of 2023 , the company employed approximately 18,000 people across more than 30 locations. [REDACTED] Media related to Lonza Group at Wikimedia Commons Diketene Diketene
168-730: The United States, the United Kingdom, Belgium, Spain, France, Mexico, Brazil, Japan, India, China and Singapore. This site accounting shows significant changes from a 2016 self-description, which listed sixteen major sites. The presence in India was established in Genome Valley , where ground was broken in 2011. In 2018, Lonza opened a 300,000 square feet (28,000 m ) facility in the United States in Pearland, Texas (a suburb of Houston). This
189-447: The company produced electricity. The following year, calcium carbide manufacture began using the electricity to heat a furnace to the 2000 °C required for quicklime to react with coal. Lonza moved to neighbouring Visp (where it retains a production site today) in 1909. Competition from electric lighting reduced demand for calcium carbide and in 1915 Lonza started industrial production of calcium cyanamide which became popular as
210-511: The end of September 2023, totaling 2 years and 11 months in the position of CEO. Chairman Albert Baehny became again, both chairman and interim CEO , as from October 2023. In May 2024, Jean-Marc Huët was elected Chairman following the retirement of Albert Baehny, who had held the position of Chairman and interim CEO. In July 2024, Wolfgang Wienand commenced his role as CEO of Lonza. As of 2023 , Lonza had over thirty development and manufacturing sites located in countries including Switzerland,
231-431: The ketene monomer: Alkylated ketenes also dimerize with ease and form substituted diketenes. Diketene readily hydrolyzes in water forming acetoacetic acid . Its half-life in water is approximately 45 min. a 25 °C at 2 < pH < 7 . Certain diketenes with two aliphatic chains , such as alkyl ketene dimers (AKDs), are used industrially to improve hydrophobicity in paper . At one time acetic anhydride
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#1732855537844252-617: The manufacture of pharmaceuticals , insecticides and dyes . For example pyrazolones are formed from substituted phenylhydrazines , they were used as analgetics but are now largely obsolete. With methylamine diketenes reacts to N , N' -dimethylacetoacetamide which is chlorinated with sulfuryl chloride and reacted with trimethyl phosphite to the highly toxic insecticide monocrotophos (especially toxic to bees). Diketenes react with substituted aromatic amines to acetoacetanilides , which are important precursors for mostly yellow, orange or red azo dyes and azo pigments. Exemplary for
273-450: The manufacture of dyestuffs and pigments. A typical reaction is: These acetoacetamides are precursors to arylide yellow and diarylide pigments . Diketenes with two alkyl chains are used in the manufacture of paper for sizing of paper in order to improve their printability (by hydrophobization ). Besides the rosin resins with about 60% share of world consumption, long chain diketenes called alkylketene dimers (AKD) are with 16% share
294-497: The most important synthetic paper sizes, they are usually used in concentrations of 0.15%, meaning 1.5 kg solid AKD/ t paper. The preparation of AKD is carried out by chlorination of long chain fatty acids (such as stearic acid , using chlorinating agents such as thionyl chloride ) to give the corresponding acid chlorides and subsequent elimination of HCl by amines (for example triethylamine ) in toluene or other solvents: Furthermore, diketenes are used as intermediates in
315-508: The same term [REDACTED] This disambiguation page lists articles associated with the title Lonza . If an internal link led you here, you may wish to change the link to point directly to the intended article. Retrieved from " https://en.wikipedia.org/w/index.php?title=Lonza&oldid=1254906433 " Categories : Disambiguation pages Disambiguation pages with surname-holder lists Hidden categories: Articles containing Italian-language text Short description
336-502: The synthesis of arylides by the reaction of diketenes with aromatic amines is: Aromatic diazonium coupling with arylides to form azo dyes, such as Pigment Yellow 74 : The industrial synthesis of the sweetener acesulfam-K is based on the reaction of diketene with sulfamic acid and cyclization by sulfur trioxide (SO 3 ). Drugs made from Diketene include: Despite its high reactivity as an alkylating agent , and unlike analogue β-lactones propiolactone and β-butyrolactone , diketene
357-433: Was initially used to make cellulose acetate for rayon manufacture, but after 1947 Lonza converted most of its ketene to diketene , which was then converted to a range of chemical precursors. Diketene capacity rose to 18'000t per year in 1993. In 1956, the production of niacin (an important vitamin ) via 5-ethyl-2-methyl-pyridine. In the 1940s, Lonza used its C2 basis to enter the vinyl chloride business. The production
378-446: Was prepared by the reaction of ketene with acetic acid: Diketene also reacts with alcohols and amines to the corresponding acetoacetic acid derivatives. The process is sometimes called acetoacetylation. An example is the reaction with 2-aminoindane : Diketene is an important industrial intermediate used for the production of acetoacetate esters and amides as well as substituted 1-phenyl-3-methylpyrazolones. The latter are used in
399-501: Was relocated to Sins and finally discontinued. At the 1959 AGM, it was decided to back integrate into petrochemistry, and Montecatini was contracted to build the world's smallest cracker in Visp. The initial failure of this plant to meet its specifications triggered a CHF12mio penalty, which Lonza used to build a research center. Lonza is involved in the manufacturing of biologics with several pharmaceutical companies. Lonza entered into
420-552: Was responsible for the global production of two-thirds of the raw materials for the Moderna vaccine at combined U.S. and Swiss facilities. As of 2024, Lonza's business areas include: In November 2019, Chairman Albert Baehny became both chairman and interim CEO of Lonza after chief executive officer (CEO) Marc Funk left after 9 months. In November 2020, Pierre-Alain Ruffieux commenced his role as Chief Executive Officer which ended at
441-578: Was started, with a process licensed from Casale. Ammonia was also converted to nitric acid . With calcium cyanamide and calcium nitrate (made from nitric acid), Lonza commercialised formulated fertilisers starting in the 1930s. At the start of World War II , Lonza was contracted by the Swiss government to produce synthetic fuel, which it did by converting acetaldehyde to paraldehyde , used as an additive in transport fuel. In 1928, ketene production started using acetic acid made by oxidation of acetaldehyde. Ketene
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