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14-1588: [REDACTED] Look up LABA , laba , laba- , or Łaba in Wiktionary, the free dictionary. Laba , Łaba , or LABA may refer to: Places [ edit ] Laba River , in Russia Bolshaya Laba River , in Russia Wadi Laba River , in Eritrea Laba Forest , protected forest in Burkina Faso Laba Township , in Lancang Lahu Autonomous County, Yunnan, China People [ edit ] Izabella Łaba (born 1966), Polish-Canadian mathematician Kodjo Fo-Doh Laba (born 1992), Togolese footballer Marianna Laba (born 1968), Ukrainian singer and musician Matías Laba (born 1991), Argentine footballer Noah Laba (born 2003), American ice hockey player Roman Laba (born 1966), Ukrainian football striker Laba Sosseh (1943–2007), Gambian son and salsa singer and composer Other uses [ edit ] Laba Festival , traditional Chinese holiday Libera Accademia di Belle Arti (LABA), Italian academy of Fine Arts Long-acting beta-adrenoceptor agonist (LABA), medication Laba language See also [ edit ] R v Laba Topics referred to by

28-483: Is different from Wikidata All article disambiguation pages All disambiguation pages LABA LABAs are designed to reduce the need for shorter-acting β 2 agonists such as salbutamol (albuterol) , as they have an approximately twelve-hour duration of action, compared to about five hours for salbutamol, making them candidates for sparing high doses of corticosteroids or treating nocturnal asthma and providing symptomatic relief for COPD patients. With

42-597: The FDA issued updated guidance on 20 December 2017, that there is no significant increased risk of serious asthma outcomes with LABAs when used together with inhaled corticosteroids. Lipophilic Lipophilicity (from Greek λίπος "fat" and φίλος "friendly") is the ability of a chemical compound to dissolve in fats , oils , lipids , and non-polar solvents such as hexane or toluene . Such compounds are called lipophilic (translated as "fat-loving" or "fat-liking" ). Such non-polar solvents are themselves lipophilic, and

56-478: The adage "like dissolves like" generally holds true. Thus lipophilic substances tend to dissolve in other lipophilic substances, whereas hydrophilic ("water-loving") substances tend to dissolve in water and other hydrophilic substances. Lipophilicity, hydrophobicity, and non-polarity may describe the same tendency towards participation in the London dispersion force , as the terms are often used interchangeably. However,

70-426: The air-water interface (lowering surface tension ) and the surfaces of the water-immiscible droplets found in oil/water emulsions (lowering interfacial tension). At these surfaces they naturally orient themselves with their head groups in water and their tails either sticking up and largely out of water (as at the air-water interface) or dissolved in the water-immiscible phase that the water is in contact with (e.g. as

84-499: The currently available long-acting β 2 adrenoceptor agonists include: International nonproprietary name (INN): Trade (brand) name Several long-acting β adrenoreceptor agonists have a duration of action of 24 hours, allowing for once-daily dosing. They are considered to be ultra-long-acting β adrenoreceptor agonists (ultra-LABAs) and are now approved. A meta-analysis study from 2006 (pooled results of 19 trials, 33,826 participants) raised concerns that Salmeterol may increase

98-494: The emulsified oil droplet). In both these configurations the head groups strongly interact with water while the tails avoid all contact with water. Surfactant molecules also aggregate in water as micelles with their head groups sticking out and their tails bunched together. Micelles draw oily substances into their hydrophobic cores, explaining the basic action of soaps and detergents used for personal cleanliness and for laundering clothes. Micelles are also biologically important for

112-411: The exception of formoterol , LABAs are not recommended for the treatment of acute asthma exacerbations because of their slower onset of action compared to salbutamol. Their long duration of action is due to the addition of a long lipophilic side-chain that binds to an exosite on adrenergic receptors. This allows the active portion of the molecule to continuously bind and unbind at β 2 receptors in

126-487: The previous meta-analysis on regular salmeterol alone is abolished by the additional use of regular inhaled corticosteroid. Large surveillance studies are ongoing to provide more information. There were no asthma-related deaths and few asthma-related serious adverse events when salmeterol is used with an inhaled steroid. At least with formoterol , an increased risk appears to be present even when steroids are used and this risk has not been ruled out for salmeterol. Some of

140-454: The risk of death in asthmatics, and that the additional risk was not reduced with the adjunctive use of inhaled steroids (e.g., as with the combination product fluticasone/salmeterol ). The proposed mechanism is that while LABAs relieve asthma symptoms, they can also promote bronchial inflammation and sensitivity without warning. On February 18, 2011, the FDA issued a safety alert for long-acting β agonists. Following new clinical safety trials,

154-444: The same term [REDACTED] This disambiguation page lists articles associated with the title Laba . If an internal link led you here, you may wish to change the link to point directly to the intended article. Retrieved from " https://en.wikipedia.org/w/index.php?title=Laba&oldid=1219655393 " Categories : Disambiguation pages Place name disambiguation pages Hidden categories: Short description

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168-448: The smooth muscle of the lungs. When combined with inhaled steroids, β adrenoceptor agonists can improve symptoms. In children this benefit is uncertain and they may be potentially harmful. They should not be used without an accompanying steroid due to an increased risk of severe symptoms, including exacerbation in both children and adults. A 2018 meta-analysis was unable to determine whether an increase serious adverse events reported in

182-477: The terms "lipophilic" and " hydrophobic " are not synonymous, as can be seen with silicones and fluorocarbons , which are hydrophobic but not lipophilic. Hydrocarbon -based surfactants are compounds that are amphiphilic (or amphipathic), having a hydrophilic, water interactive "end", referred to as their "head group", and a lipophilic "end", usually a long chain hydrocarbon fragment, referred to as their "tail". They congregate at low energy surfaces, including

196-507: The transport of fatty substances in the small intestine surface in the first step that leads to the absorption of the components of fats (largely fatty acids and 2-monoglycerides). Cell membranes are bilayer structures principally formed from phospholipids , molecules which have a highly water interactive, ionic phosphate head groups attached to two long alkyl tails. By contrast, fluorosurfactants are not amphiphilic or detergents because fluorocarbons are not lipophilic. Oxybenzone ,

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