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106-523: Most Hồi Chánh Viên recruited into the fledgling Kit Carson Scout program had defected to Saigon's side in the war because they suffered either from malaria or grave wounds beyond what could be medically treated with the rudimentary medical care available on the VC/PAVN side. Those who volunteered for selection and training as Kit Carson Scouts had, during their service with the enemy, little or no contact with anyone speaking English. Few had any knowledge at all of

212-575: A blood meal from a previously Plasmodium infected person or animal. Parasites are then typically introduced by the bite of an infected Anopheles mosquito. Some of these inoculated parasites, called " sporozoites ", probably remain in the skin, but others travel in the bloodstream to the liver , where they invade hepatocytes . They grow and divide in the liver for 2–10 days, with each infected hepatocyte eventually harboring up to 40,000 parasites. The infected hepatocytes break down, releasing these invasive Plasmodium cells, called " merozoites ", into

318-462: A child under five died of malaria in 2021, and "many of these deaths are preventable and treatable". Malaria is commonly associated with poverty and has a significant negative effect on economic development. In Africa, it is estimated to result in losses of US$ 12 billion a year due to increased healthcare costs, lost ability to work, and adverse effects on tourism. The term malaria originates from Medieval Italian : mala aria 'bad air',

424-659: A class of insecticides with low toxicity . They are most effective when used from dusk to dawn. It is recommended to hang a large "bed net" above the center of a bed and either tuck the edges under the mattress or make sure it is large enough such that it touches the ground. ITNs are beneficial towards pregnancy outcomes in malaria-endemic regions in Africa but more data is needed in Asia and Latin America. Hoi An Hội An ( Vietnamese: [hôjˀ aːn] ), formerly known in

530-414: A consistent supply of microscopy slides and stains. In places where microscopy is unavailable, malaria is diagnosed with RDTs, rapid antigen tests that detect parasite proteins in a fingerstick blood sample. A variety of RDTs are commercially available, targeting the parasite proteins histidine rich protein 2 (HRP2, detects P. falciparum only), lactate dehydrogenase , or aldolase . The HRP2 test

636-462: A distinctive regional cuisine that blends centuries of cultural influences from East and Southeast Asia. Hoi An hosts a number of cooking classes where tourists can learn to make Cao lầu or braised spiced pork noodle, a signature dish of the city. The Hoi An wreck , a shipwreck from the late fifteenth or early sixteenth century, was discovered near the Cham Islands , off the coast of the city in

742-472: A greater likelihood of complications and death. Malaria infection affects the immune responses following vaccination for various diseases. For example, malaria suppresses immune responses to polysaccharide vaccines. A potential solution is to give curative treatment before vaccination in areas where malaria is present. Due to the non-specific nature of malaria symptoms, diagnosis is typically suspected based on symptoms and travel history, then confirmed with

848-453: A laboratory test showing hemoglobin levels below 8 grams per deciliter of blood. In areas of the world with little to no malaria, the WHO recommends only testing people with possible exposure to malaria (typically travel to a malaria-endemic area) and unexplained fever. In sub-Saharan Africa, testing is low, with only about one in four (28%) of children with a fever receiving medical advice or

954-477: A laboratory test to detect the presence of the parasite in the blood (parasitological test). In areas where malaria is common, the World Health Organization (WHO) recommends clinicians suspect malaria in any person who reports having fevers, or who has a current temperature above 37.5 °C without any other obvious cause. Malaria should be suspected in children with signs of anemia : pale palms or

1060-534: A large amount of sweat on the surface of the skin. Due to the high levels of lactic acid released from the human body, it has been hypothesized to represent a specific human host-recognition cue for anthropophilic (attracted to humans) mosquitoes. Pungent foot odor Most studies use human odors as stimuli to attract host seeking mosquitoes and have reported a strong and significant attractive effect. The studies have found human odor samples very effective in attracting mosquitoes. Foot odors have been demonstrated to have

1166-636: A less pronounced and almost continuous fever. Symptoms typically begin 10–15 days after the initial mosquito bite, but can occur as late as several months after infection with some P. vivax strains. Travellers taking preventative malaria medications may develop symptoms once they stop taking the drugs. Severe malaria is usually caused by P. falciparum (often referred to as falciparum malaria). Symptoms of falciparum malaria arise 9–30 days after infection. Individuals with cerebral malaria frequently exhibit neurological symptoms, including abnormal posturing , nystagmus , conjugate gaze palsy (failure of

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1272-591: A major trading centre at the port village of Faifo. Since 1570, Southern Vietnam had been under the control of the powerful Nguyễn clan , established by governor Nguyễn Hoàng . The Nguyễn lords were far more interested in commercial activity than the Trịnh lords who ruled the north. As a result, Hội An flourished as a trading port and became the most important trade port on the South China Sea . Captain William Adams ,

1378-410: A minimum of 100 scouts per division was necessary to ensure effectiveness with a target of 1,500 scouts by the end of 1968. In 1968, the number of Kit Carson Scouts increased from 132 to 476, with 102 serving with the 1st Marine Division, 106 with the 3rd Marine Division , 153 with the 101st Airborne Division , and 115 with the 23rd Infantry Division , with a further 22 undergoing training. Throughout

1484-542: A nominal rank (not official) of staff sergeant . From October to December 1966, III Marine Amphibious Force (III MAF) credited Kit Carson Scouts with killing 47 VC, recovering 16 weapons and discovering 18 mines and tunnels. By the end of 1966, 19 scouts were serving with the 1st Marine Division. By the end of 1967, the 132 Scouts serving with the Marines in I Corps were credited with killing 58 more VC, capturing 37 and recovering 82 weapons. General Lewis William Walt ordered

1590-435: A non-invasive way to detect malarial infections. In addition, these volatile compounds were heavily detected by mosquito antennae as an attractant, making the children more vulnerable to the bite of the mosquitos. Fatty acids Fatty acids have been identified as an attractive compound for mosquitoes, they are typically found in volatile emissions from the skin. These fatty acids that produce body odor profiles originate from

1696-559: A part of miasma theory ; the disease was formerly called ague or marsh fever due to its association with swamps and marshland. The term appeared in English at least as early as 1768. Malaria was once common in most of Europe and North America, where it is no longer endemic, though imported cases do occur. The scientific study of malaria is called malariology. Adults with malaria tend to experience chills and fever—classically in periodic intense bouts lasting around six hours, followed by

1802-530: A period of sweating and fever relief—as well as headache, fatigue, abdominal discomfort, and muscle pain . Children tend to have more general symptoms: fever, cough, vomiting, and diarrhea. Initial manifestations of the disease—common to all malaria species—are similar to flu-like symptoms , and can resemble other conditions such as sepsis , gastroenteritis , and viral diseases . The presentation may include headache , fever , shivering , joint pain , vomiting , hemolytic anemia , jaundice , hemoglobin in

1908-562: A postdoctoral scholar at the University of California, Berkeley studying the structural basis of membrane manipulation and cell-cell fusion by bacterial pathogens, discusses studies that determine how odor profiles can be used to diagnose the disease. Within the study, samples of volatile compounds from around 400 children within schools in Western Kenya were collected - to identify asymptomatic infections. These biomarkers have been established as

2014-626: A rapid diagnostic test in 2021. There was a 10-percentage point gap in testing between the richest and the poorest children (33% vs 23%). Additionally, a greater proportion of children in Eastern and Southern Africa (36%) were tested than in West and Central Africa (21%). According to UNICEF, 61% of children with a fever were taken for advice or treatment from a health facility or provider in 2021. Disparities are also observed by wealth, with an 18 percentage point difference in care-seeking behaviour between children in

2120-466: A short time, and a "thin film" of blood, allowing them to clearly see individual parasites and identify the infecting Plasmodium species. Under typical field laboratory conditions, a microscopist can detect parasites when there are at least 100 parasites per microliter of blood, which is around the lower range of symptomatic infection. Microscopic diagnosis is relatively resource intensive, requiring trained personnel, specific equipment, electricity, and

2226-579: A small proportion of public expenditure on health. In contrast, a similar programme in Tanzania would cost an estimated one-fifth of the public health budget. In 2021, the World Health Organization confirmed that China has eliminated malaria. In 2023, the World Health Organization confirmed that Azerbaijan , Tajikistan , and Belize have eliminated malaria. In areas where malaria is common, children under five years old often have anaemia , which

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2332-586: A training center west of Danang for 28 days of training and evaluation. Class sizes were small, usually consisting of no more than eight men. Training including fieldcraft, field sketching, use of sensors and basic English. As the Marines redeployed from South Vietnam the number of Kit Carson Scouts serving with III MAF dropped to 111 in July and 95 in December. During 1970, III MAF scouts were credited with killing 43 VC, capturing 313 and recovering 96 weapons. A report given to

2438-510: A way past the net. Insecticide-treated nets (ITNs) are estimated to be twice as effective as untreated nets and offer greater than 70% protection compared with no net. Between 2000 and 2008, the use of ITNs saved the lives of an estimated 250,000 infants in Sub-Saharan Africa. According to UNICEF, only 36% of households had sufficient ITNs for all household members in 2019. In 2000, 1.7 million (1.8%) African children living in areas of

2544-433: Is a mosquito-borne infectious disease that affects vertebrates and Anopheles mosquitoes. Human malaria causes symptoms that typically include fever , fatigue , vomiting , and headaches . In severe cases, it can cause jaundice , seizures , coma , or death . Symptoms usually begin 10 to 15 days after being bitten by an infected Anopheles mosquito . If not properly treated, people may have recurrences of

2650-479: Is a feature of blackwater fever , where haemoglobin from lysed red blood cells leaks into the urine. Infection with P. falciparum may result in cerebral malaria, a form of severe malaria that involves encephalopathy . It is associated with retinal whitening, which may be a useful clinical sign in distinguishing malaria from other causes of fever. An enlarged spleen , enlarged liver or both of these , severe headache, low blood sugar , and haemoglobin in

2756-441: Is a history museum located at 10B Trần Hưng Đạo. According to CNN , Hoi An is the " banh mi capital of Vietnam." Banh Mi is a type of Vietnamese sandwich, consisting of a baguette, pâté, meats and fresh herbs. Cao lầu is a signature dish of the town, consisting of rice noodles, meat, greens, bean sprouts, and herbs, most commonly served with a small amount of broth, with a strong resemblance to Japanese udon . The water for

2862-515: Is adorned with radiant, handcrafted lanterns, creating a surreal and mesmerizing atmosphere that transports participants back in time. The festival encapsulates the unique blend of influences in Hoi An, including Chinese, Japanese, and European, making it an exceptional showcase of cultural diversity. In addition to the visual spectacle, the festival also offers a diverse array of street food, traditional music performances, and rituals that engage attendees in

2968-630: Is also a popular local drink among tourists. The Hoi An Lantern Festival, a renowned cultural event in Hoi An, Vietnam , is a celebration of light, color, and tradition. This vibrant and enchanting festival is held on the 14th day of each lunar month when the moon is at its brightest. As of 2023, the festival dates coincide with the following Gregorian calendar dates: 5 February, 6 March, 5 April, 4 May, 3 June, 2 July, 1 August, 30 August, 29 September, 28 October, 27 November, 26 December; offering an extraordinary experience to both residents and tourists. Throughout

3074-518: Is associated with potentially life-threatening conditions about as often as with a diagnosis of P. falciparum infection. P. vivax proportionally is more common outside Africa. Some cases have been documented of human infections with several species of Plasmodium from higher apes , but except for P. knowlesi —a zoonotic species that causes malaria in macaques —these are mostly of limited public health importance. The Anopheles mosquitos initially get infected by Plasmodium by taking

3180-505: Is between February and May, when the weather becomes very mild with moderate temperature and less humid. Calm mild weather is now limited to the season of May/June - end of August when the seas are calm and wind changes direction and comes from the South. The remainder of the year the weather is intermittent between rain & cold and hot & mild. Activities such as visiting the offshore Cù lao Chàm islands are only guaranteed to be likely during

3286-446: Is caused by six Plasmodium species: P. falciparum , P. malariae , P. ovale curtisi , P. ovale wallikeri , P. vivax and P. knowlesi . Among those infected, P. falciparum is the most common species identified (~75%) followed by P. vivax (~20%). Although P. falciparum traditionally accounts for the majority of deaths, recent evidence suggests that P. vivax malaria

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3392-465: Is deemed severe when any of the following criteria are present, otherwise it is considered uncomplicated. Cerebral malaria is defined as a severe P. falciparum -malaria presenting with neurological symptoms, including coma (with a Glasgow coma scale less than 11, or a Blantyre coma scale less than 3), or with a coma that lasts longer than 30 minutes after a seizure. Methods used to prevent malaria include medications, mosquito elimination and

3498-531: Is insufficient evidence that mosquito repellents can prevent malaria infection. Insecticide-treated nets (ITNs) and indoor residual spraying (IRS) are effective, have been commonly used to prevent malaria, and their use has contributed significantly to the decrease in malaria in the 21st century. ITNs and IRS may not be sufficient to eliminate the disease, as these interventions depend on how many people use nets, how many gaps in insecticide there are (low coverage areas), if people are not protected when outside of

3604-451: Is not available. In areas where the disease is common, malaria should be confirmed if possible before treatment is started due to concerns of increasing drug resistance . Resistance among the parasites has developed to several antimalarial medications; for example, chloroquine -resistant P. falciparum has spread to most malarial areas, and resistance to artemisinin has become a problem in some parts of Southeast Asia . The disease

3710-514: Is recognized as a well-preserved example of a Southeast Asian trading port dating from the 15th to the 19th century , its buildings and street plan reflecting a blend of indigenous and foreign influences. Prominent in the city's old town is its covered " Japanese Bridge ", dating to the 16th–17th century. Hội An is one of the locations set in the opera "Princess Anio." Hội An ( chữ Hán : 會 安) translates as "peaceful meeting place" from Sino-Vietnamese. In English and other European languages,

3816-400: Is relatively invisible to immune surveillance. However, circulating infected blood cells are destroyed in the spleen . To avoid this fate, the P. falciparum parasite displays adhesive proteins on the surface of the infected blood cells, causing the blood cells to stick to the walls of small blood vessels, thereby sequestering the parasite from passage through the general circulation and

3922-449: Is sometimes due to malaria. Giving children with anaemia in these areas preventive antimalarial medication improves red blood cell levels slightly but does not affect the risk of death or need for hospitalisation. Vector control refers to methods used to decrease malaria by reducing the levels of transmission by mosquitoes. For individual protection, the most effective insect repellents are based on DEET or picaridin . However, there

4028-408: Is spread exclusively through bites of infected female Anopheles mosquitoes. The mosquito bite introduces the parasites from the mosquito's saliva into a person's blood. The parasites travel to the liver , where they mature and reproduce. Five species of Plasmodium commonly infect humans. The three species associated with more severe cases are P. falciparum (which is responsible for

4134-406: Is the largest two-storey wooden building in the old town, at 57m long and 9m wide, with fronts at Nguyen Thai Hoc St and Bach Dang St. On the second floor, there are 490 artifacts, organised into four areas: plastic folk arts, performing folk arts, traditional occupations and artifacts related to the daily life of Hoi An residents. The Museum of Trade Ceramics is located at 80 Tran Phu Street, and

4240-425: Is typical) to several years. After a period of dormancy, they reactivate and produce merozoites. Hypnozoites are responsible for long incubation and late relapses in P. vivax infections, although their existence in P. ovale is uncertain. The parasite is relatively protected from attack by the body's immune system because for most of its human life cycle it resides within the liver and blood cells and

4346-413: Is typically attributed to treatment failure. People may develop some immunity when exposed to frequent infections. Malaria infection develops via two phases: one that involves the liver (exoerythrocytic phase), and one that involves red blood cells, or erythrocytes (erythrocytic phase). When an infected mosquito pierces a person's skin to take a blood meal, sporozoites in the mosquito's saliva enter

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4452-757: Is widely used in Africa, where P. falciparum predominates. However, since HRP2 persists in the blood for up to five weeks after an infection is treated, an HRP2 test sometimes cannot distinguish whether someone currently has malaria or previously had it. Additionally, some P. falciparum parasites in the Amazon region lack the HRP2 gene, complicating detection. RDTs are fast and easily deployed to places without full diagnostic laboratories. However they give considerably less information than microscopy, and sometimes vary in quality from producer to producer and lot to lot. Serological tests to detect antibodies against Plasmodium from

4558-512: Is widespread in the tropical and subtropical regions that exist in a broad band around the equator . This includes much of sub-Saharan Africa , Asia , and Latin America . In 2022, some 249 million cases of malaria worldwide resulted in an estimated 608,000 deaths, with 80 percent being five years old or less. Around 95% of the cases and deaths occurred in sub-Saharan Africa. Rates of disease decreased from 2010 to 2014, but increased from 2015 to 2021. According to UNICEF, nearly every minute,

4664-696: The 1st Australian Task Force , followed by the Royal Thai Army Expeditionary Division in August 1969 and South Korean forces in December 1970. At the beginning of 1970, over 2,300 scouts served with U.S. forces, with 165 serving in the III MAF. III MAF recruited potential scouts from Chiêu Hồi centers in Da Nang and Hoi An . An experienced Marine NCO investigated the background of motivation of each potential recruit and those who passed would then go to

4770-603: The Sinai in Egypt. Hội An's importance waned sharply at the end of the 18th century because of the collapse of Nguyễn rule, which resulted from the Tây Sơn Rebellion - which was opposed to foreign trade. In 1775, Hội An had been the battleground between the Trịnh army and Tây Sơn rebels, where the city was destroyed in the process. Then, with the triumph of Emperor Gia Long , he repaid

4876-411: The bone marrow for 11 days, then return to the blood circulation to await uptake by the bite of another mosquito. Once inside a mosquito, the gametocytes undergo sexual reproduction, and eventually form daughter sporozoites that migrate to the mosquito's salivary glands to be injected into a new host when the mosquito bites. The liver infection causes no symptoms; all symptoms of malaria result from

4982-491: The polymerase chain reaction to detect the parasite's DNA have been developed, but they are not widely used in areas where malaria is common, due to their cost and complexity. The risk of disease can be reduced by preventing mosquito bites through the use of mosquito nets and insect repellents or with mosquito-control measures such as spraying insecticides and draining standing water . Several medications are available to prevent malaria for travellers in areas where

5088-659: The 1990s. Between 1996 and 1999, nearly three hundred thousand artifacts were recovered by the excavation teams, that included the Vietnamese National Salvage Corporation and Oxford University’s Marine Archaeology Research Division. Another attraction is the Hoi An Lantern Full Moon Festival taking place every full moon cycle. The celebrations honour the ancestors. People exchange flowers, lanterns, candles, and fruits for prosperity and good fortune. The Hoi An Memories Show, performed at

5194-545: The American frontiersman . The first six Kit Carson Scouts were placed in the field with the 1st Marine Regiment and 9th Marine Regiments as part of a trial program in October 1966. All but one of the original group of six would later be killed in action. The VC defectors initially recruited to work as intelligence scouts with USMC infantry units were paid by the U.S. military and were treated as staff non-commissioned officers with

5300-489: The English language, creating a communication challenge as they were deployed with American units. A further complication was that almost all Hồi Chánh Viên had a distrust of South Vietnamese soldiers and interpreters because of the degree to which friendly forces had been infiltrated by enemy agents. As the program evolved, recruitment of non-military VC cadre and defecting PAVN officers were added, and these Kit Carson Scouts also became valuable sources of military intelligence in

5406-475: The English sailor and confidant of Tokugawa Ieyasu , is known to have made one trading mission to Hội An in 1617 on a Red Seal Ship . The early Portuguese Jesuits also had one of their two residences at Hội An. Hội An was a divided town with the Japanese settlement across the " Japanese Bridge ", constructed in the 16th-17th century. The bridge (Chùa Cầu) is a unique covered structure built by Japanese merchants,

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5512-468: The French for their aid by giving them exclusive trade rights to the nearby port town of Đà Nẵng . Between 1907 and 1915, Tramway de l’Îlot de l’Observatoire operated from Đà Nẵng. As Đà Nẵng became the new centre of trade, and with maintenance difficulties, the tramway ended its operations. In May 1945, a group of 11 civilians of the resistance movement, including the composer La Hoi , were executed by

5618-486: The Hoi An Impression Theme Park, is a large-scale outdoor theatrical performance that showcases the city's 400-year history. The show features over 500 performers on a 25,000-square-meter stage, depicting Hoi An's transformation from a rural village into a major Southeast Asian trading port. In 2019, Hoi An was listed as one of Vietnam's key culture-based tourist areas where rampant tourism growth "threatens

5724-537: The Japanese imperial army. In August, Hoi An became one of the earliest towns to seize power. Local historians also say that Hội An lost its status as a desirable trade port due to the silting up of the river mouth. The result was that Hội An remained almost untouched by the changes to Vietnam over the next 200 years. The efforts to revive the city were only done in the 1990s by a Polish architect and conservator from Lublin and influential cultural educator, Kazimierz Kwiatkowski , who finally brought back Hội An to

5830-607: The Sa Huỳnh culture—considered to be the original settlers on the Hội An site—dating to over 2000 years ago. This museum is considered to be the most unusual collection of Sa Huỳnh artefacts in Vietnam. The Precious Heritage Art Gallery Museum is located at 26 Phan Boi Chau. It includes a 500m2 display of photos and artifacts collected by Réhahn during the past 10 years of the French photographer's explorations of Vietnam. The Hội An Museum ,

5936-593: The U.S. Senate Foreign Relations Committee in February 1970 listed 230 Kit Carson Scouts killed in action and 716 wounded.In June 1970, as part of the Vietnamization program, the Kit Carson Program name was changed to Lực Lượng 66 (Vietnamese for Force 66), but Kit Carson Scouts numbers declined as U.S. forces withdrew from South Vietnam with only 400 scouts serving by the end of 1970. Malaria Malaria

6042-679: The Western world as Faifoo or Faifo , is a city of approximately 120,000 people in Vietnam's Quảng Nam Province , registered as a UNESCO World Heritage Site since 1999. Along with the Cù Lao Cham archipelago, it is part of the Cù Lao Cham-Hội An Biosphere Reserve , designated in 2009. In 2023, Hội An was registered in the UNESCO Creative Cities Network list. Old Town Hội An, the city's historic district,

6148-405: The absence of Duffy antigens on red blood cells. The impact of sickle cell trait on malaria immunity illustrates some evolutionary trade-offs that have occurred because of endemic malaria. Sickle cell trait causes a change in the haemoglobin molecule in the blood. Normally, red blood cells have a very flexible, biconcave shape that allows them to move through narrow capillaries ; however, when

6254-418: The blood have been developed, but are not used for malaria diagnosis due to their relatively poor sensitivity and specificity. Highly sensitive nucleic acid amplification tests have been developed, but are not used clinically due to their relatively high cost, and poor specificity for active infections. Malaria is classified into either "severe" or "uncomplicated" by the World Health Organization (WHO). It

6360-430: The bloodstream and migrate to the liver where they infect hepatocytes, multiplying asexually and asymptomatically for a period of 8–30 days. After a potential dormant period in the liver, these organisms differentiate to yield thousands of merozoites, which, following rupture of their host cells, escape into the blood and infect red blood cells to begin the erythrocytic stage of the life cycle. The parasite escapes from

6466-540: The bloodstream. In the blood, the merozoites rapidly invade individual red blood cells , replicating over 24–72 hours to form 16–32 new merozoites. The infected red blood cell lyses, and the new merozoites infect new red blood cells, resulting in a cycle that continuously amplifies the number of parasites in an infected person. Over rounds of this infection cycle, a small portion of parasites do not replicate, but instead develop into early sexual stage parasites called male and female " gametocytes ". These gametocytes develop in

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6572-408: The brain, they contribute to coma . In the placenta they contribute to low birthweight and preterm labor, and increase the risk of abortion and stillbirth. The destruction of red blood cells during infection often results in anemia, exacerbated by reduced production of new red blood cells during infection. Only female mosquitoes feed on blood; male mosquitoes feed on plant nectar and do not transmit

6678-596: The broth has been traditionally taken from the Ba Le Well, thought to have been built in the 10th century by the Chams . Other regional specialties include Mi quang noodles, Banh bao banh vac , Hoanh thanh , com ga (chicken with rice), bánh xèo , sweet corn soup and baby clam salad are also regional specialties. Chili sauce, Ớt Tương Triều Phát, is also produced locally. In addition, herbal teas with natural ingredients such as licorice, cinnamon, chamomile, lemongrass, etc. It

6784-434: The cause, recurrence can be classified as either recrudescence , relapse , or reinfection. Recrudescence is when symptoms return after a symptom-free period due to failure to remove blood-stage parasites by adequate treatment. Relapse is when symptoms reappear after the parasites have been eliminated from the blood but have persisted as dormant hypnozoites in liver cells. Relapse commonly occurs between 8 and 24 weeks after

6890-485: The conduct of the war. The concept of using soldiers who had previously fought on the enemy side in this way originated in late 1966 with the 5th Counterintelligence Team, which had counterintelligence tasks within the Da Nang Chiêu Hồi Center as one responsibility. Major General Herman Nickerson Jr. , commanding the 1st Marine Division (1st MARDIV) at the time, named them Kit Carson Scouts after Kit Carson

6996-521: The development of respiratory distress , which occurs in up to 25% of adults and 40% of children with severe P. falciparum malaria. Possible causes include respiratory compensation of metabolic acidosis , noncardiogenic pulmonary oedema , concomitant pneumonia , and severe anaemia . Although rare in young children with severe malaria, acute respiratory distress syndrome occurs in 5–25% of adults and up to 29% of pregnant women. Coinfection of HIV with malaria increases mortality. Kidney failure

7102-504: The disease in the long run, but the initial costs required are out of reach of many of the world's poorest people. There is a wide difference in the costs of control (i.e. maintenance of low endemicity) and elimination programs between countries. For example, in China—whose government in 2010 announced a strategy to pursue malaria elimination in the Chinese provinces —the required investment is

7208-578: The disease is common. Occasional doses of the combination medication sulfadoxine/pyrimethamine are recommended in infants and after the first trimester of pregnancy in areas with high rates of malaria. As of 2023, two malaria vaccines have been endorsed by the World Health Organization . The recommended treatment for malaria is a combination of antimalarial medications that includes artemisinin . The second medication may be either mefloquine , lumefantrine , or sulfadoxine/pyrimethamine. Quinine , along with doxycycline , may be used if artemisinin

7314-469: The disease months later. In those who have recently survived an infection, reinfection usually causes milder symptoms. This partial resistance disappears over months to years if the person has no continuing exposure to malaria. The mosquito vector is itself harmed by Plasmodium infections, causing reduced lifespan. Human malaria is caused by single-celled microorganisms of the Plasmodium group. It

7420-462: The disease. Females of the mosquito genus Anopheles prefer to feed at night. They usually start searching for a meal at dusk, and continue through the night until they succeed. However, in Africa, due to the extensive use of bed nets, they began to bite earlier, before bed-net time. Malaria parasites can also be transmitted by blood transfusions , although this is rare. Symptoms of malaria can recur after varying symptom-free periods. Depending upon

7526-568: The early years, Mỹ Sơn was the spiritual capital, Trà Kiệu was the political capital and Hội An was the commercial capital of the Chams, they later moved further down towards Nha Trang . The river system was used for the transport of goods between the highlands , as well as the inland countries of Laos and Thailand and its lowlands. In 1306, the Vietnamese and the Chams signed a land treaty, in which Cham king Jaya Simhavarman III gave Đại Việt

7632-494: The eyes to turn together in the same direction), opisthotonus , seizures , or coma . Diagnosis based on skin odor profiles Humans emanate a large range of smells. Studies have been conducted on how to detect human malaria infections through volatile compounds from the skin - suggesting that volatile biomarkers may be a reliable source for the detection of infection, including those asymptomatic. Using skin body odor profiles can be efficient in diagnosing global populations, and

7738-442: The frequency with which malaria parasites complete their life cycle in the cell. Individuals who are homozygous (with two copies of the abnormal haemoglobin beta allele ) have sickle-cell anaemia , while those who are heterozygous (with one abnormal allele and one normal allele) experience resistance to malaria without severe anaemia. Although the shorter life expectancy for those with the homozygous condition would tend to disfavour

7844-541: The heritage from tourism. Owing to the increased number of tourists visiting Hoi An a variety of activities are emerging that allow guests to get out of the old quarter and explore by motorbike, bicycle, kayak, or motorboat. The Thu Bon River is still essential to the region more than 500 years after António de Faria first navigated it and it remains an essential form of food production and transport. As such kayak and motorboat rides are becoming an increasingly common tourist activity. This longtime trading port city offers

7950-399: The highest attractiveness to anthropophilic mosquitoes. Some of these studies have included traps that had been baited with nylon socks previously worn by human participants and were deemed efficient in catching adult mosquitos. Foot odors have high numbers of volatile compounds, which in turn elicit an olfactory response from mosquitoes. Malaria has several serious complications , including

8056-429: The home, and an increase in mosquitoes that are resistant to insecticides. Modifications to people's houses to prevent mosquito exposure may be an important long term prevention measure. Mosquito nets help keep mosquitoes away from people and reduce infection rates and transmission of malaria. Nets are not a perfect barrier and are often treated with an insecticide designed to kill the mosquito before it has time to find

8162-423: The infection of red blood cells. Symptoms develop once there are more than around 100,000 parasites per milliliter of blood. Many of the symptoms associated with severe malaria are caused by the tendency of P. falciparum to bind to blood vessel walls, resulting in damage to the affected vessels and surrounding tissue. Parasites sequestered in the blood vessels of the lung contribute to respiratory failure . In

8268-502: The initial symptoms and is often seen in P. vivax and P. ovale infections. P. vivax malaria cases in temperate areas often involve overwintering by hypnozoites, with relapses beginning the year after the mosquito bite. Reinfection means that parasites were eliminated from the entire body but new parasites were then introduced. Reinfection cannot readily be distinguished from relapse and recrudescence, although recurrence of infection within two weeks of treatment ending

8374-634: The liver undetected by wrapping itself in the cell membrane of the infected host liver cell. Within the red blood cells, the parasites multiply further, again asexually, periodically breaking out of their host cells to invade fresh red blood cells. Several such amplification cycles occur. Thus, classical descriptions of waves of fever arise from simultaneous waves of merozoites escaping and infecting red blood cells. Some P. vivax sporozoites do not immediately develop into exoerythrocytic-phase merozoites, but instead, produce hypnozoites that remain dormant for periods ranging from several months (7–10 months

8480-431: The metabolism of glycerol, lactic acid, amino acids, and lipids - through the action of bacteria found within the skin. They create a “chemical signature” for the mosquitoes to locate a potential host, humans in particular. Lactic acid Lactic acid, a naturally produced levorotatory isomer, has been titled an attractant of mosquitoes for a long time. Lactic acid is predominantly produced by eccrine-sweat glands, creating

8586-504: The modified haemoglobin S molecules are exposed to low amounts of oxygen, or crowd together due to dehydration, they can stick together forming strands that cause the cell to distort into a curved sickle shape. In these strands, the molecule is not as effective in taking or releasing oxygen, and the cell is not flexible enough to circulate freely. In the early stages of malaria, the parasite can cause infected red cells to sickle, and so they are removed from circulation sooner. This reduces

8692-486: The only known covered bridge with a Buddhist temple attached on one side. In the 18th century, Hội An was considered by Chinese and Japanese merchants to be the best destination for trading in all of Southeast Asia. The city also rose to prominence as a powerful and exclusive trade conduit between Europe, China, India, and Japan, especially for the ceramic industry. Shipwreck discoveries have shown that Vietnamese and other Asian ceramics were transported from Hội An to as far as

8798-624: The parasite eventually disappears from that area, as happened in North America, Europe, and parts of the Middle East. However, unless the parasite is eliminated from the whole world, it could re-establish if conditions revert to a combination that favors the parasite's reproduction. Furthermore, the cost per person of eliminating anopheles mosquitoes rises with decreasing population density, making it economically unfeasible in some areas. Prevention of malaria may be more cost-effective than treatment of

8904-451: The prevention of bites. As of 2023, there are two malaria vaccines , approved for use in children by the WHO: RTS,S and R21 . The presence of malaria in an area requires a combination of high human population density, high Anopheles mosquito population density and high rates of transmission from humans to mosquitoes and from mosquitoes to humans. If any of these is lowered sufficiently,

9010-840: The program to be adopted throughout III MAF and a Kit Carson training center was established at Da Nang to standardize training. On 29 April 1967, the Intelligence Section of the Military Assistance Command, Vietnam (MACV) published a procedural document detailing the expansion of the Kit Carson Scout Program for all active U.S. Army units in the country, including the scout's terms of service and wages. In September 1967, General William Westmoreland issued an order directing all infantry divisions in Vietnam, including U.S. Army units, to begin using Kit Carson Scouts in conjunction with friendly operations. He directed that

9116-632: The rich tapestry of Vietnamese traditions. Visitors to the Hoi An Lantern Festival can expect a plethora of activities and experiences that cater to all ages and preferences. As the sun sets, the town's streets come alive with the soft glow of lanterns. One of the highlights is the ritual of releasing floating lanterns on the Thu Bon River, symbolizing the sending away of worries and bad luck, and welcoming good fortune. Traditional music and dance performances are held at various locations throughout

9222-411: The richest (71%) and the poorest (53%) households. Malaria is usually confirmed by the microscopic examination of blood films or by antigen -based rapid diagnostic tests (RDT). Microscopy—i.e. examining Giemsa -stained blood with a light microscope —is the gold standard for malaria diagnosis. Microscopists typically examine both a "thick film" of blood, allowing them to scan many blood cells in

9328-437: The screening and monitoring of infection to officially eradicate malaria. Research findings have predominantly relied on chemical explanations to explain the differences in attractiveness among humans based on distinct odor profiles. The existence of volatile compounds, like fatty acids, and lactic acid is an essential reason on why some individuals are more appealing to mosquitos than others. Volatile compounds Kanika Khanna,

9434-496: The short season from May to the end of August, which is the high season for domestic tourism. In 1999 the old town was declared a World Heritage Site by UNESCO as a well-preserved example of a Southeast Asian trading port of the 15th to 19th centuries, with buildings that display a blend of local and foreign influences. According to the UNESCO Impact Report 2008 on Hội An, there are challenges for stakeholders to protect

9540-563: The spleen. The blockage of the microvasculature causes symptoms such as those in placental malaria. Sequestered red blood cells can breach the blood–brain barrier and cause cerebral malaria. Due to the high levels of mortality and morbidity caused by malaria—especially the P. falciparum species—it has placed the greatest selective pressure on the human genome in recent history. Several genetic factors provide some resistance to it including sickle cell trait , thalassaemia traits, glucose-6-phosphate dehydrogenase deficiency , and

9646-617: The strategic spice trade and with this came increasing wealth. The early history of Hội An is that of the Chams. These Austronesian-speaking Malayo-Polynesian people created the Kingdom of Champa which occupied much of what is now central and lower Vietnam , from Huế to beyond Nha Trang . Various linguistic connections between Cham and the related Jarai language and the Austronesian languages of Indonesia (particularly Acehnese ), Malaysia , and Hainan have been documented. In

9752-552: The surrounding area. The port mouth and boats are still used for both fishing and tourism. Hoi An has two main seasons during the year: rainy and dry seasons, with a warm average temperature of 29 °C during the year. The hottest period is from June to August when the highest temperature can reach 38 °C during day time. November to January are the coldest months, with an average temperature of 20 °C. The rainy season lasts from September to January with heavy rains which can cause floods and affect tourism. The city's dry season

9858-478: The sustainability". Excessive tourism in the past has also damaged the eco-system of Chàm Islands-Hội An Marine Protected Area. The city has four museums highlighting the history of the region. These museums are managed by the Hoi An Center for Cultural Heritage Management and Preservation. Entrance to the museum is permitted with a Hoi An Entrance Ticket. The Museum of History and Culture, at 13 Nguyen Hue St,

9964-464: The town was known historically as Faifo . This word is derived from Vietnamese Hội An phố (the town of Hội An), which was shortened to "Hoi-pho", and then to "Faifo". It has also been known by various other Vietnamese names, including Hải Phố, Hoài Phố, Hội Phố, and Hoa Phố. During the Champa period, it was named Lam Ap Pho. Between the 7th and 10th centuries, the Chams (people of Champa ) controlled

10070-402: The town, providing insight into Vietnam's artistic heritage. Furthermore, visitors can indulge in a delectable array of street food, from savory dishes to sweet treats, making the festival a true culinary delight. Hoi An Lantern Festival continues to capture the hearts and imagination of all who partake, ensuring that this captivating event remains an integral part of Hoi An's cultural identity and

10176-605: The trait's survival, the trait is preserved in malaria-prone regions because of the benefits provided by the heterozygous form. Liver dysfunction as a result of malaria is uncommon and usually only occurs in those with another liver condition such as viral hepatitis or chronic liver disease . The syndrome is sometimes called malarial hepatitis . While it has been considered a rare occurrence, malarial hepatopathy has seen an increase, particularly in Southeast Asia and India. Liver compromise in people with malaria correlates with

10282-451: The two provinces of Ô and Lý in exchange for a long-term peace and marriage with emperor Trần Nhân Tông 's daughter Huyền Trân . In 1471, Emperor Lê Thánh Tông of Đại Việt annexed Champa and Hội An became a Vietnamese territory, and also became the capital of Quảng Nam Province . In 1535, Portuguese explorer and sea captain António de Faria , coming from Đà Nẵng , tried to establish

10388-415: The urine with kidney failure may occur. Complications may include spontaneous bleeding, coagulopathy , and shock . Malaria during pregnancy can cause stillbirths , infant mortality , miscarriage , and low birth weight , particularly in P. falciparum infection, but also with P. vivax . Malaria is caused by infection with parasites in the genus Plasmodium . In humans, malaria

10494-424: The urine , retinal damage , and convulsions . The classic symptom of malaria is paroxysm —a cyclical occurrence of sudden coldness followed by shivering and then fever and sweating, occurring every two days ( tertian fever ) in P. vivax and P. ovale infections, and every three days ( quartan fever ) for P. malariae . P. falciparum infection can cause recurrent fever every 36–48 hours, or

10600-401: The vast majority of malaria deaths), P. vivax , and P. knowlesi (a simian malaria that spills over into thousands of people a year). P. ovale and P. malariae generally cause a milder form of malaria. Malaria is typically diagnosed by the microscopic examination of blood using blood films , or with antigen-based rapid diagnostic tests . Methods that use

10706-427: The world where malaria is common were protected by an ITN. That number increased to 20.3 million (18.5%) African children using ITNs in 2007, leaving 89.6 million children unprotected and to 68% African children using mosquito nets in 2015. The percentage of children sleeping under ITNs in sub-Saharan Africa increased from less than 40% in 2011 to over 50% in 2021. Most nets are impregnated with pyrethroids ,

10812-457: The world. There is a statue of the Polish architect in the city, and remains a symbol of the relationship between Poland and Vietnam , which share many historical similarities despite their distance. Today, the town is a tourist attraction because of its history, traditional architecture, and crafts such as textiles and ceramics. Many bars, hotels, and resorts have been constructed both in Hội An and

10918-580: The year, Kit Carson Scouts were credited with killing 312 VC/PAVN, apprehending 851 suspects as well as locating 720 tunnels and supply caches and over 1,300 booby-traps. During 1969, the number of Kit Carson Scouts working with III MAF grew from 476 to 597 despite the redeployment of the 3rd Marine Division during the year. The Kit Carson Scouts were credited with killing 191 VC/PAVN, capturing 539 and recovering 195 weapons, and locating 143 tunnels and caches and 518 booby-traps. In January 1969, Kit Carson Scouts began being assigned to Allied forces, starting with

11024-414: The year, the festival showcases Hoi An's rich heritage, featuring a stunning display of thousands of lanterns illuminating the ancient town and the serene Thu Bon River. The Hoi An Lantern Festival holds a special place in the hearts of locals and visitors alike. It serves as a platform to celebrate Vietnam's culture and heritage, fostering a sense of community and unity. During the festival, the entire town

11130-457: Was established in 1995, in a restored wooden building, originally built around 1858. The items originating from Persia, China, Thailand, India and other countries are proof of the importance of Hội An as a major trading port in South East Asia. The Museum of Sa Huỳnh Culture , is located at 149 Tran Phu Street. Established in 1994, this museum displays a collection of over 200 artifacts from

11236-565: Was originally a pagoda, built in the 17th century by Minh Huong villagers to worship the Guanyin , and is adjacent to the Guan Yu temple. It contains original relics from the Sa Huynh, Champa, Dai Viet and Dai Nam periods, tracing the history of Hoi An's inhabitants from its earliest settlers through to French colonial times. The Hoi An Folklore Museum, at 33 Nguyen Thai Hoc Street, was opened in 2005, and

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