Misplaced Pages

#86913

56-447: The predecessor corporation was Invitrogen Corporation (formerly traded as Nasdaq :  IVGN ), headquartered in Carlsbad, California . In 2008, a merger between Applied Biosystems and Invitrogen was finalized, creating Life Technologies. The latter was acquired by Thermo Fisher Scientific in 2014. Invitrogen was founded in 1987 by Lyle Turner, Joe Fernandez, and William McConnell and

112-525: A contract from the Defense Threat Reduction Agency (DTRA) , the company developed a prototype hand-held pathogen detection system for the detection of multiple toxins such as ricin , staphylococcal enterotoxin , and botulinum toxin , as well as bacteria that cause anthrax , plague , and other diseases, in a single sample. Invitrogen was also awarded a contract to provide kits for detecting possible E. coli O157 contamination in food at

168-713: A large number of products: Dynabeads magnetic separation technology, GIBCO cell culture media and reagents, SuperScript reverse transcriptase , Platinum Taq polymerase , TOPO cloning and expression products, Novex protein electrophoresis products, and numerous fluorescent reagents such as Qdot nanocrystals , Alexa Fluor , DyLight , RiboGreen and SYBR dyes. Invitrogen currently offers more than 25,000 products and services to support research in cellular analysis, genomics , proteomics , and drug discovery , and seeks to address research problems in developing fields, including biodefense and environmental diagnostics, bioinformatics , epigenetics , and stem cell research. Under

224-509: A process involving meiosis and fertilization . Meiosis involves the intimate pairing of homologous chromosomes and recombination between them. Examples of eukaryotic pathogens capable of sex include the protozoan parasites Plasmodium falciparum , Toxoplasma gondii , Trypanosoma brucei , Giardia intestinalis , and the fungi Aspergillus fumigatus , Candida albicans and Cryptococcus neoformans . Viruses may also undergo sexual interaction when two or more viral genomes enter

280-697: A reagent company called Bethesda Research Laboratories. The company continued to add technologies through a series of mergers and acquisitions, which broadened its customer base and strengthened its intellectual property portfolio. Among these, established companies such as Ethrog Biotechnology, Molecular Probes ( fluorescence -based detection), Dynal (magnetic bead–based separation), Panvera (proteins and assays for drug screening ), InforMax (software for computational biology and bioinformatics), BioSource (cellular pathway analysis), CellzDirect (cell products and services for research) and Zymed and Caltag Laboratories (primary and secondary antibodies ) have been brought under

336-437: A theorized equilibrium between a pathogen spreading to additional hosts to parasitize resources, while lowering their virulence to keep hosts living for vertical transmission to their offspring. Algae are single-celled eukaryotes that are generally non-pathogenic. Green algae from the genus Prototheca lack chlorophyll and are known to cause the disease protothecosis in humans, dogs, cats, and cattle, typically involving

392-423: A variety of bacterial, viral, fungal, and parasitic pathogens, cholera is only caused by some strains of Vibrio cholerae . Additionally, some pathogens may only cause disease in hosts with an immunodeficiency . These opportunistic infections often involve hospital-acquired infections among patients already combating another condition. Infectivity involves pathogen transmission through direct contact with

448-413: A variety of immunodeficiency disorders caused by viruses related to human immunodeficiency virus (HIV), such as BIV and FIV . Humans can be infected with many types of pathogens, including prions, viruses, bacteria, and fungi, causing symptoms like sneezing, coughing, fever, vomiting, and potentially lethal organ failure . While some symptoms are caused by the pathogenic infection, others are caused by

504-758: A wide array of pathogens and it has been estimated that only 3% of the disease caused by plant pathogens can be managed. Animals often get infected with many of the same or similar pathogens as humans including prions, viruses, bacteria, and fungi. While wild animals often get illnesses, the larger danger is for livestock animals. It is estimated that in rural settings, 90% or more of livestock deaths can be attributed to pathogens. Animal transmissible spongiform encephalopathy (TSEs) involving prions include bovine spongiform encephalopathy (mad cow disease), chronic wasting disease , scrapie , transmissible mink encephalopathy , feline spongiform encephalopathy , and ungulate spongiform encephalopathy. Other animal diseases include

560-414: A wide variety of issues such as shorter plant height, growths or pits on tree trunks, root or seed rot, and leaf spots. Common and serious plant fungi include the rice blast fungus , Dutch elm disease , chestnut blight and the black knot and brown rot diseases of cherries, plums, and peaches. It is estimated that pathogenic fungi alone cause up to a 65% reduction in crop yield. Overall, plants have

616-765: Is an American stock exchange based in New York City . It is the most active stock trading venue in the U.S. by volume, and ranked second on the list of stock exchanges by market capitalization of shares traded, behind the New York Stock Exchange . The exchange platform is owned by Nasdaq, Inc. , which also owns the Nasdaq Nordic stock market network and several U.S.-based stock and options exchanges . Although it trades stock of healthcare, financial, media, entertainment, retail, hospitality, and food businesses, it focuses more on technology stocks . The exchange

SECTION 10

#1732859584087

672-413: Is an accepted version of this page In biology , a pathogen ( Greek : πάθος , pathos "suffering", "passion" and -γενής , -genēs "producer of"), in the oldest and broadest sense, is any organism or agent that can produce disease. A pathogen may also be referred to as an infectious agent , or simply a germ . The term pathogen came into use in the 1880s. Typically, the term pathogen

728-510: Is called microbiology , while parasitology refers to the scientific study of parasites and the organisms that host them. There are several pathways through which pathogens can invade a host. The principal pathways have different episodic time frames, but soil has the longest or most persistent potential for harboring a pathogen. Diseases in humans that are caused by infectious agents are known as pathogenic diseases. Not all diseases are caused by pathogens, such as black lung from exposure to

784-621: Is made up of both American and foreign firms, with China and Israel being the largest foreign sources. "Nasdaq" was initially an acronym for the National Association of Securities Dealers Automated Quotations. It was founded in 1971 by the National Association of Securities Dealers (NASD), now known as the Financial Industry Regulatory Authority . On February 8, 1971, the Nasdaq stock market began operations as

840-651: Is resistant to the commonly prescribed beta-lactam antibiotics . A 2013 report from the Centers for Disease Control and Prevention (CDC) estimated that in the United States, at least 2 million people get an antibiotic-resistant bacterial infection annually, with at least 23,000 of those patients dying from the infection. Due to their indispensability in combating bacteria, new antibiotics are required for medical care. One target for new antimicrobial medications involves inhibiting DNA methyltransferases , as these proteins control

896-574: Is the most common cause of thrush , and Cryptococcus neoformans , which can cause a severe form of meningitis . Typical fungal spores are 4.7 μm long or smaller. Prions are misfolded proteins that transmit their abnormal folding pattern to other copies of the protein without using nucleic acids . Besides obtaining prions from others, these misfolded proteins arise from genetic differences, either due to family history or sporadic mutations. Plants uptake prions from contaminated soil and transport them into their stem and leaves, potentially transmitting

952-400: Is used to describe an infectious microorganism or agent, such as a virus, bacterium, protozoan , prion , viroid , or fungus . Small animals, such as helminths and insects, can also cause or transmit disease. However, these animals are usually referred to as parasites rather than pathogens. The scientific study of microscopic organisms, including microscopic pathogenic organisms,

1008-697: The 2008 Summer Olympcics in Beijing , China . The monitoring program, based on World Health Organization food standards, is conducted by the Beijing Centers for Disease Control and Prevention (CDC) and the Olympic Food Safety program. Similarly, the company's PathAlert technology was selected to monitor Yersinia pestis , the causative agent of the plague, at the Torino Winter Games in 2006 . Their Qubit platform for RNA, DNA, and protein quantitation

1064-632: The Baltimore classification separates viruses by seven classes of mRNA production: Protozoans are single-celled eukaryotes that feed on microorganisms and organic tissues. Many protozoans act as pathogenic parasites to cause diseases like malaria , amoebiasis , giardiasis , toxoplasmosis , cryptosporidiosis , trichomoniasis , Chagas disease , leishmaniasis , African trypanosomiasis (sleeping sickness), Acanthamoeba keratitis , and primary amoebic meningoencephalitis (naegleriasis). Parasitic worms (helminths) are macroparasites that can be seen by

1120-531: The London Stock Exchange to form the first intercontinental linkage of capital markets . In 1996, the SEC issued a report alleging that Nasdaq market makers fixed prices by avoiding "odd-eighths" quotes (at the time, stock prices were quoted in increments of an eighth of a dollar) to artificially widen spreads. The report was followed by a new set of rules for how Nasdaq handled orders. In 1998, it became

1176-584: The NASDAQ Financial-100 Index, which tracks the largest 100 companies in terms of market capitalization . On March 10, 2000, the NASDAQ Composite stock market index peaked at 5,132.52, but fell to 3,227 by April 17, and, in the following 30 months, fell 78% from its peak. In a series of sales in 2000 and 2001, FINRA sold its stake in the Nasdaq. On July 2, 2002, Nasdaq Inc. became a public company via an initial public offering . In 2006,

SECTION 20

#1732859584087

1232-439: The anthrax vaccine and pneumococcal vaccine . Many other bacterial pathogens lack vaccines as a preventive measure, but infection by these bacteria can often be treated or prevented with antibiotics . Common antibiotics include amoxicillin , ciprofloxacin , and doxycycline . Each antibiotic has different bacteria that it is effective against and has different mechanisms to kill that bacteria. For example, doxycycline inhibits

1288-405: The echinocandin family of drugs and fluconazole . While algae are commonly not thought of as pathogens, the genus Prototheca causes disease in humans . Treatment for protothecosis is currently under investigation, and there is no consistency in clinical treatment. Many pathogens are capable of sexual interaction. Among pathogenic bacteria , sexual interaction occurs between cells of

1344-449: The tobacco mosaic virus which caused scientist Martinus Beijerinck to coin the term "virus" in 1898. Bacterial plant pathogens cause leaf spots, blight, and rot in many plant species. The most common bacterial pathogens for plants are Pseudomonas syringae and Ralstonia solanacearum , which cause leaf browning and other issues in potatoes, tomatoes, and bananas. Fungi are another major pathogen type for plants. They can cause

1400-651: The Clustered Regularly Interspaced Short Palindromic Repeats ( CRISPR ) associated with bacteriophages, removing the viral genes to avoid infection. This mechanism has been modified for artificial CRISPR gene editing . Plants can play host to a wide range of pathogen types, including viruses, bacteria, fungi, nematodes, and even other plants. Notable plant viruses include the papaya ringspot virus , which has caused millions of dollars of damage to farmers in Hawaii and Southeast Asia, and

1456-653: The EMiniCME. Below are the contract specifications for the Nasdaq 100 and derivatives. Nasdaq quotes are available at three levels: The Nasdaq Stock Market sessions, with times in the Eastern Time Zone are: 7:00 a.m. to 9:30 a.m.: extended-hours trading session (premarket) 9:30 a.m. to 4:00 p.m.: normal trading session 4:00 p.m. to 8:00 p.m.: extended-hours trading session (postmarket) The Nasdaq Stock Market averages about 253 trading days per year. The Nasdaq Stock Market has three different market tiers: After

1512-511: The Invitrogen brand. Invitrogen acquired Sequitur in 2003 to obtain Sequitur's proprietary Stealth(TM) RNAi technology. In 2008, Invitrogen virtually doubled its size with the purchase of biotech instrumentation company Applied Biosystems , maker of DNA sequencing and PCR machines and reagents. The company then renamed the overall organization as Life Technologies. The Invitrogen brand and most of

1568-450: The NYSE, Nasdaq is the second largest stock exchange in the United States with a market capitalization of $ 19 trillion, which is about $ 5.5 trillion less than the NYSE as of 2021. Nasdaq is a much younger organization than the NYSE, having been founded in just 1971. In addition to age and market capitalization, there are other key differences between the two exchanges: Pathogen This

1624-508: The bodily fluids or airborne droplets of infected hosts, indirect contact involving contaminated areas/items, or transfer by living vectors like mosquitos and ticks . The basic reproduction number of an infection is the expected number of subsequent cases it is likely to cause through transmission. Virulence involves pathogens extracting host nutrients for their survival, evading host immune systems by producing microbial toxins and causing immunosuppression . Optimal virulence describes

1680-413: The brands acquired still exist on product packaging, although the overall company is called Life Technologies. In summer 2010, the company acquired the computer chip DNA sequencing company Ion Torrent Systems. Through this history of acquisitions and continued product research and development, Invitrogen / Life Technologies had over 50,000 products. Utilizing this business strategy, Invitrogen represented

1736-640: The company's set of tools for growth. Invitrogen acquired NOVEX, in cloned protein characterization, within 60 days of going public. In December 1999, it purchased Research Genetics, Inc., a leader in genomics and synthetic DNA chemistry, becoming a $ 100 million (annual sales) company within a year of its IPO. The business scope expanded significantly when it acquired the rival biotechnology and cell culture company Life Technologies in 2000; Life had been formed in 1983 when GIBCO (Grand Island Biological Company) which had been founded around 1960 in New York, merged with

Invitrogen - Misplaced Pages Continue

1792-634: The continued price increases when selling market data . In December 2020, NASDAQ announced that it would strip its indexes of four Chinese companies in response to Executive Order 13959 . In September 2024, the European Commission said it had carried out an unannounced inspection at the offices of Nasdaq over potential anti-competitive practices. Nasdaq 100 futures are traded on the CME (Chicago Mercantile Exchange) while its derivatives, E-Mini Nasdaq 100 and Micro E-Mini Nasdaq 100 futures are traded on

1848-529: The eve of the United Nations Conference on Sustainable Development (Rio+20). In November 2016, chief operating officer Adena Friedman was promoted to chief executive officer , becoming the first woman to run a major exchange in the U.S. In 2016, Nasdaq earned $ 272 million in listings-related revenues. In October 2018, the SEC ruled that the New York Stock Exchange and Nasdaq did not justify

1904-461: The first stock market in the United States to trade online, using the slogan "the stock market for the next hundred years". The Nasdaq Stock Market attracted many companies during the dot-com bubble . Its main index is the NASDAQ Composite , which has been published since its inception. The QQQ exchange-traded fund tracks the large-cap NASDAQ-100 index, which was introduced in 1985 alongside

1960-768: The highest disease burdens , killing 1.6 million people in 2021, mostly in Africa and Southeast Asia. Bacterial pneumonia is primarily caused by Streptococcus pneumoniae , Staphylococcus aureus , Klebsiella pneumoniae , and Haemophilus influenzae . Foodborne illnesses typically involve Campylobacter , Clostridium perfringens , Escherichia coli , Listeria monocytogenes , and Salmonella . Other infectious diseases caused by pathogenic bacteria include tetanus , typhoid fever , diphtheria , and leprosy . Fungi are eukaryotic organisms that can function as pathogens. There are approximately 300 known fungi that are pathogenic to humans, including Candida albicans , which

2016-505: The host genome, and hijack the host's machinery to produce hundreds of new viruses until the cell bursts open to release them for additional infections. The lytic cycle describes this active state of rapidly killing hosts, while the lysogenic cycle describes potentially hundreds of years of dormancy while integrated in the host genome. Alongside the taxonomy organized by the International Committee on Taxonomy of Viruses (ICTV),

2072-458: The immune system of the host, so that when the potential host encounters the virus in the wild, the immune system can defend against infection quickly. Vaccines designed against viruses include annual influenza vaccines and the two-dose MMR vaccine against measles , mumps , and rubella . Vaccines are not available against the viruses responsible for HIV/AIDS , dengue , and chikungunya . Treatment of viral infections often involves treating

2128-420: The immune system's efforts to kill the pathogen, such as feverishly high body temperatures meant to denature pathogenic cells. Despite many attempts, no therapy has been shown to halt the progression of prion diseases . A variety of prevention and treatment options exist for some viral pathogens. Vaccines are one common and effective preventive measure against a variety of viral pathogens. Vaccines prime

2184-572: The levels of expression for other genes, such as those encoding virulence factors. Infection by fungal pathogens is treated with anti-fungal medication. Athlete's foot , jock itch , and ringworm are fungal skin infections that are treated with topical anti-fungal medications like clotrimazole . Infections involving the yeast species Candida albicans cause oral thrush and vaginal yeast infections . These internal infections can either be treated with anti-fungal creams or with oral medication. Common anti-fungal drugs for internal infections include

2240-461: The monthly Stock Guides (stock guides and procedures) issued by Standard & Poor's Corporation. Over the years, it became more of a stock market by adding trade and volume reporting and automated trading systems. In 1981, Nasdaq traded 37% of the U.S. securities markets' total of 21 billion shares. By 1991, Nasdaq's share had grown to 46%. In 1992, the Nasdaq Stock Market joined with

2296-583: The naked eye. Worms live and feed in their living host, acquiring nutrients and shelter in the digestive tract or bloodstream of their host. They also manipulate the host's immune system by secreting immunomodulatory products which allows them to live in their host for years. Helminthiasis is the generalized term for parasitic worm infections, which typically involve roundworms , tapeworms , and flatworms . While bacteria are typically viewed as pathogens, they serve as hosts to bacteriophage viruses (commonly known as phages). The bacteriophage life cycle involves

Invitrogen - Misplaced Pages Continue

2352-453: The pollutant coal dust , genetic disorders like sickle cell disease , and autoimmune diseases like lupus . Pathogenicity is the potential disease-causing capacity of pathogens, involving a combination of infectivity (pathogen's ability to infect hosts) and virulence (severity of host disease). Koch's postulates are used to establish causal relationships between microbial pathogens and diseases. Whereas meningitis can be caused by

2408-822: The prions to herbivorous animals . Additionally, wood, rocks, plastic, glass, cement, stainless steel, and aluminum have been shown binding, retaining, and releasing prions, showcasing that the proteins resist environmental degradation. Prions are best known for causing transmissible spongiform encephalopathy (TSE) diseases like Creutzfeldt–Jakob disease (CJD), variant Creutzfeldt–Jakob disease (vCJD), Gerstmann–Sträussler–Scheinker syndrome (GSS), fatal familial insomnia (FFI), and kuru in humans. While prions are typically viewed as pathogens that cause protein amyloid fibers to accumulate into neurodegenerative plaques, Susan Lindquist led research showing that yeast use prions to pass on evolutionarily beneficial traits. Not to be confused with virusoids or viruses, viroids are

2464-589: The same species by the process of genetic transformation . Transformation involves the transfer of DNA from a donor cell to a recipient cell and the integration of the donor DNA into the recipient genome through genetic recombination . The bacterial pathogens Helicobacter pylori , Haemophilus influenzae , Legionella pneumophila , Neisseria gonorrhoeae , and Streptococcus pneumoniae frequently undergo transformation to modify their genome for additional traits and evasion of host immune cells. Eukaryotic pathogens are often capable of sexual interaction by

2520-530: The smallest known infectious pathogens. Viroids are small single-stranded, circular RNA that are only known to cause plant diseases, such as the potato spindle tuber viroid that affects various agricultural crops. Viroid RNA is not protected by a protein coat, and it does not encode any proteins, only acting as a ribozyme to catalyze other biochemical reactions. Viruses are generally between 20–200 nm in diameter. For survival and replication, viruses inject their genome into host cells, insert those genes into

2576-688: The soil-associated species Prototheca wickerhami . Bacteria are single-celled prokaryotes that range in size from 0.15 and 700 μM. While the vast majority are either harmless or beneficial to their hosts, such as members of the human gut microbiome that support digestion, a small percentage are pathogenic and cause infectious diseases. Bacterial virulence factors include adherence factors to attach to host cells, invasion factors supporting entry into host cells, capsules to prevent opsonization and phagocytosis , toxins, and siderophores to acquire iron. The bacterial disease tuberculosis , primarily caused by Mycobacterium tuberculosis , has one of

2632-812: The status of the Nasdaq Stock Market was changed from a stock market to a licensed national securities exchange. In 2007, it merged with OMX, a leading exchange operator in the Nordic countries, expanded its global footprint, and changed its name to the NASDAQ OMX Group. To qualify for listing on the exchange, a company must be registered with the United States Securities and Exchange Commission (SEC), must have at least three market makers (financial firms that act as brokers or dealers for specific securities) and must meet minimum requirements for assets, capital, public shares, and shareholders. In February 2011, in

2688-537: The symptoms of the infection, rather than providing medication to combat the viral pathogen itself. Treating the symptoms of a viral infection gives the host immune system time to develop antibodies against the viral pathogen. However, for HIV, highly active antiretroviral therapy (HAART) is conducted to prevent the viral disease from progressing into AIDS as immune cells are lost. Much like viral pathogens, infection by certain bacterial pathogens can be prevented via vaccines. Vaccines against bacterial pathogens include

2744-461: The synthesis of new proteins in both gram-negative and gram-positive bacteria , which makes it a broad-spectrum antibiotic capable of killing most bacterial species. Due to misuse of antibiotics, such as prematurely ended prescriptions exposing bacteria to evolutionary pressure under sublethal doses, some bacterial pathogens have developed antibiotic resistance . For example, a genetically distinct strain of Staphylococcus aureus called MRSA

2800-420: The viruses injecting their genome into bacterial cells, inserting those genes into the bacterial genome, and hijacking the bacteria's machinery to produce hundreds of new phages until the cell bursts open to release them for additional infections. Typically, bacteriophages are only capable of infecting a specific species or strain. Streptococcus pyogenes uses a Cas9 nuclease to cleave foreign DNA matching

2856-480: The wake of an announced merger of NYSE Euronext with Deutsche Börse , speculation developed that NASDAQ OMX and Intercontinental Exchange (ICE) could mount a counter-bid of their own for NYSE. NASDAQ OMX could be looking to acquire the American exchange's cash equities business, ICE the derivatives business. At the time, "NYSE Euronext's market value was $ 9.75 billion. Nasdaq was valued at $ 5.78 billion, while ICE

SECTION 50

#1732859584087

2912-460: The world's first electronic stock market. At first, it was merely a "quotation system" and did not provide a way to perform electronic trades. The NASDAQ Stock Market eventually assumed the majority of major trades that had been executed by the over-the-counter (OTC) system of trading, but there are still many securities traded in this fashion. As late as 1987, the Nasdaq exchange was still commonly referred to as "OTC" in media reports and also in

2968-636: Was awarded an R&D 100 Award as being a "Top 100 Technologically Significant New Product" by R&D Magazine . Invitrogen developed and introduced stem cell products. Among more than 1,200 products for stem cell research, the company offered an engineered stem cell line (BG01v/hOG) and various STEMPRO products for manual passaging of human embryonic stem cells (hESC), to promote hESC growth and expansion, and to allow scientists to ascertain hESC pluripotency . Nasdaq The Nasdaq Stock Market ( / ˈ n æ z d æ k / ; National Association of Securities Dealers Automated Quotations)

3024-535: Was founded as a European equivalent to the Nasdaq Stock Market. It was purchased by NASDAQ in 2001 and became NASDAQ Europe. In 2003, operations were shut down as a result of the burst of the dot-com bubble . In 2007, NASDAQ Europe was revived first as Equiduct and was acquired by Börse Berlin later that year. On June 18, 2012, Nasdaq OMX became a founding member of the United Nations Sustainable Stock Exchanges Initiative on

3080-715: Was incorporated in 1989. The company initially found success with its kits for molecular cloning —notably, The Librarian, a kit for making cDNA libraries, and the FastTrack Kit for mRNA isolation from biological samples. William McConnell left the company in 1989. In 1999, the company, which had reached sales of $ 33 million the prior year, went public, with a plan of consolidating biotechnology research boutique suppliers. The company had become quite successful at licensing technologies into its niche market, of cloning and expression, but determined that many niche leaders were not interested in licensing, and M&A needed to be added to

3136-646: Was valued at $ 9.45 billion." Late in the month, Nasdaq was reported to be considering asking either ICE or the Chicago Mercantile Exchange to join in what would probably have to be, if it proceeded, an $ 11–12 billion counterbid. In December 2005, NASDAQ acquired Instinet for $ 1.9 billion, retaining the Inet ECN and subsequently selling the agency brokerage business to Silver Lake Partners and Instinet management. The European Association of Securities Dealers Automatic Quotation System (EASDAQ)

#86913