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39-445: IPBC was initially developed for use in the paint & coatings industry as a dry-film preservative to protect interior and exterior coatings from mold, mildew, and fungal growth, while also offering cost performance and sustainability benefits. IPBC exhibits efficacy against a broad spectrum of fungal species, typically at very low use levels. IPBC today is incorporated into a wide variety of interior and exterior paint formulations around

78-426: A runny nose , as well as allergic conjunctivitis , which includes watering and itchy eyes. Also an initial tickle on the roof of the mouth or in the back of the throat may be experienced. Also, depending on the season, the symptoms may be more severe and people may experience coughing , wheezing , and irritability. A few people even become depressed, lose their appetite , or have problems sleeping. Moreover, since

117-445: A cold include: Among seasonal allergies, there are some allergens that fuse together and produce a new type of allergy. For instance, grass pollen allergens cross-react with food allergy proteins in vegetables such as onion, lettuce, carrots, celery, and corn. Besides, the cousins of birch pollen allergens, like apples, grapes, peaches, celery, and apricots, produce severe itching in the ears and throat. The cypress pollen allergy brings

156-425: A cross reactivity between diverse species like olive, privet, ash and Russian olive tree pollen allergens. In some rural areas, there is another form of seasonal grass allergy, combining airborne particles of pollen mixed with mold. Recent research has suggested that humans might develop allergies as a defense to fight off parasites. According to Yale University Immunologist Ruslan Medzhitov , protease allergens cleave

195-432: A major source of airborne allergens. The basidospore family include mushrooms, rusts, smuts, brackets, and puffballs . The airborne spores from mushrooms reach levels comparable to those of mold and pollens. The levels of mushroom respiratory allergy are as high as 30 percent of those with allergic disorder, but it is believed to be less than 1 percent of food allergies. Heavy rainfall (which increases fungal spore release)

234-406: A physical exam, doctors can make a diagnosis to identify if the patient has a seasonal allergy. After performing the diagnosis, the doctor is able to tell the main cause of the allergic reaction and recommend the treatment to follow. 2 tests have to be done in order to determine the cause: a blood test and a skin test. Allergists do skin tests in one of two ways: either dropping some purified liquid of

273-547: A report of the Safety Assessment of IPBC by the Cosmetic Ingredient Review [CIR Final Report, Lanigan 1998]. This final report found IPBC to be a non-carcinogen with no genotoxicity and in reproductive and developmental toxicity studies using rats and mice, IPBC had no significant effect on fertility, reproductive performance, or on the incidence of fetal malformation [Lanigan, 1998]. The study, "Final Report on

312-617: A variety of sources, such as dust mite excretion, pollen , pet dander , or even royal jelly . Food allergies are not as common as food sensitivity , but some foods such as peanuts (a legume ), nuts , seafood and shellfish are the cause of serious allergies in many people. The United States Food and Drug Administration recognizes nine foods as major food allergens: peanuts, tree nuts, eggs, milk, shellfish, fish, wheat, soy, and most recently sesame, as well as sulfites (chemical-based, often found in flavors and colors in foods) at 10ppm and over. In other countries, due to differences in

351-624: Is a high count of eosinophils, an allergic condition might be present. Another laboratory test is the blood test for IgE (immunoglobulin production), such as the radioallergosorbent test (RAST) or the more recent enzyme allergosorbent tests (EAST), implemented to detect high levels of allergen-specific IgE in response to particular allergens. Although blood tests are less accurate than the skin tests, they can be performed on patients unable to undergo skin testing. Imaging tests can be useful to detect sinusitis in people who have chronic rhinitis, and they can work when other test results are ambiguous. There

390-501: Is a predominant air-borne allergen affecting up to 22 percent of patients with respiratory allergies. Some fungal air-borne allergens such as Coprinus comatus are associated with worsening of eczematous skin lesions. Children who are born during autumn months (during fungal spore season) are more likely to develop asthmatic symptoms later in life. Treatment includes over-the-counter medications , antihistamines , nasal decongestants , allergy shots , and alternative medicine . In

429-421: Is a relatively new preservative for cosmetic products and will presumably increase in usage [Sasseville, 2004]. Most human patch tests performed before 2004 were with 0.1% IPBC solutions, i.e. 10 times the concentration used in many cosmetic products. Some used 0.5% IPBC. In 2004, it was suggested that a better concentration for tests of this substance would be 0.2% [Brasch et al., 2004] and this has contributed to

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468-471: Is a very low reaction rate, but it is not zero, and the industry reports this low rate of reaction even though in the largest study of 25,435 subjects over 69% of the reactions were either weak or doubtful [Warshaw et al., 2013a]. These combined studies showing prevalence of reaction below 1% means that IPBC at this time does not have the reaction rates necessary to be included as an allergen in standard allergy series. But, it remains under close monitoring as it

507-508: Is also a newer second generation of antihistamines that are generally classified as the " non-sedating antihistamines " or anti-drowsy, which include cetirizine , loratadine , and fexofenadine . An example of nasal decongestants is pseudoephedrine and its side-effects include insomnia , restlessness , and difficulty urinating. Some other nasal sprays are available by prescription, including Azelastine and Ipratropium . Some of their side-effects include drowsiness. For eye symptoms, it

546-505: Is also nasal endoscopy, wherein a tube is inserted through the nose with a small camera to view the passageways and examine any irregularities in the nose structure. Endoscopy can be used for some cases of chronic or unresponsive seasonal rhinitis. In 1952 basidiospores were described as being possible airborne allergens and were linked to asthma in 1969. Basidiospores are the dominant airborne fungal allergens. Fungal allergies are associated with seasonal asthma. They are considered to be

585-690: Is an antigen that is capable of stimulating a type-I hypersensitivity reaction in atopic individuals through immunoglobulin E (IgE) responses. Most humans mount significant Immunoglobulin E responses only as a defense against parasitic infections . However, some individuals may respond to many common environmental antigens. This hereditary predisposition is called atopy . In atopic individuals, non-parasitic antigens stimulate inappropriate IgE production, leading to type I hypersensitivity. Sensitivities vary widely from one person (or from one animal) to another. A very broad range of substances can be allergens to sensitive individuals. Allergens can be found in

624-696: Is associated with increased hospital admissions of children with asthma. A study in New Zealand found that 22 percent of patients with respiratory allergic disorders tested positive for basidiospores allergies. Mushroom spore allergies can cause either immediate allergic symptomatology or delayed allergic reactions. Those with asthma are more likely to have immediate allergic reactions and those with allergic rhinitis are more likely to have delayed allergic responses. A study found that 27 percent of patients were allergic to basidiomycete mycelia extracts and 32 percent were allergic to basidiospore extracts, thus demonstrating

663-475: Is bad news for millions of asthmatics in the United States whose asthma attacks are triggered by seasonal allergies. Indeed, seasonal allergies are one of the main triggers for asthma, along with colds or flu, cigarette smoke and exercise. In Canada, for example, up to 75% of asthmatics also have seasonal allergies. Based on the symptoms seen on the patient, the answers given in terms of symptom evaluation and

702-415: Is important to first bath the eyes with plain eyewashes to reduce the irritation. People should not wear contact lenses during episodes of conjunctivitis. Allergen immunotherapy treatment involves administering doses of allergens to accustom the body to induce specific long-term tolerance. Allergy immunotherapy can be administered orally (as sublingual tablets or sublingual drops), or by injections under

741-403: Is known as parasitology . Medical parasitology is concerned with three major groups of parasites: parasitic protozoa , helminths , and parasitic arthropods . Parasitic diseases are thus considered those diseases that are caused by pathogens belonging taxonomically to either the animal kingdom , or the protozoan kingdom . Although organisms such as bacteria function as parasites,

780-406: Is mostly found in cosmetics at about one-eighth that level [Maier et al., 2009]. IPBC Toxicity and Safety Tests show it to be generally safe: When used properly in leave-on skin products, IPBC is extremely safe [Steinberg, 2002]. Previous to being approved for cosmetic use in 1996, extensive safety and toxicity tests were conducted on IPBC and their results were gathered along with earlier studies in

819-417: Is the administration of sterile epinephrine to the person experiencing anaphylaxis, which suppresses the body's overreaction to the allergen, and allows for the patient to be transported to a medical facility. In addition to foreign proteins found in foreign serum (from blood transfusions ) and vaccines , common allergens include: Seasonal allergy symptoms are commonly experienced during specific parts of

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858-423: The sinuses may also become congested, some people experience headaches . If both parents have had allergies in the past, there is a 66% chance for the individual to experience seasonal allergies, and the risk lowers to 60% if just one parent has had allergies. The immune system also has strong influence on seasonal allergies, because it reacts differently to diverse allergens like pollen. When an allergen enters

897-511: The IPBC which was presumably an allergen for these patients [Toholka & Nixon, 2014; Pazzaglia & Tosti, 1999]. Post-1996 tests of human sensitivity to IPBC have all shown quite low sensitivity, having overall reported human skin testing (patch test) on 53,774 subjects with only 491 of those subjects showing any reaction (0.8%) to IPBC. In every study, positive patch test reactions occurred in less than 1% of subjects tested in all but one study. This

936-408: The Safety Assessment of Iodopropynyl Butylcarbamate", discusses the results of 32 studies between 1990 and 1994 in 3,582 subjects using skin application of IPBC at relevant concentrations. All 32 studies showed no evidence of contact sensitization compared to placebo controls, with the report stating "With each test formulation, a few panelists had erythema, edema, and/or a papular response, but overall,

975-542: The allergen from a fully cooked, usually baked, state research suggests that a tolerance can emerge to certain egg and milk allergies under the supervision of a dietitian or specialist. The suitability of this treatment is debated between UK and North American experts. Parasitic infection A parasitic disease , also known as parasitosis , is an infectious disease caused by parasites . Parasites are organisms which derive sustenance from its host while causing it harm. The study of parasites and parasitic diseases

1014-495: The allergen onto the skin and pricking the area with a small needle; or injecting a small amount of allergen under the skin. Alternative tools are available to identify seasonal allergies, such as laboratory tests, imaging tests, and nasal endoscopy. In the laboratory tests, the doctor will take a nasal smear and it will be examined microscopically for factors that may indicate a cause: increased numbers of eosinophils (white blood cells), which indicates an allergic condition. If there

1053-411: The allergen—consuming food or drink one is sensitive to (ingestion), breathing in pollen, perfume or pet dander (inhalation), or brushing a body part against an allergy-causing plant (direct contact). Other common causes of serious allergy are wasp , fire ant and bee stings, penicillin , and latex . An extremely serious form of an allergic reaction is called anaphylaxis . One form of treatment

1092-525: The body of an individual that is predisposed to allergies, it triggers an immune reaction and the production of antibodies. These allergen antibodies migrate to mast cells lining the nose, eyes, and lungs. When an allergen drifts into the nose more than once, mast cells release a slew of chemicals or histamines that irritate and inflame the moist membranes lining the nose and produce the symptoms of an allergic reaction: scratchy throat, itching, sneezing and watery eyes. Some symptoms that differentiate allergies from

1131-567: The case of nasal symptoms, antihistamines are normally the first option. They may be taken together with pseudoephedrine to help relieve a stuffy nose and they can stop the itching and sneezing. Some over-the-counter options are Benadryl and Tavist . However, these antihistamines may cause extreme drowsiness, therefore, people are advised to not operate heavy machinery or drive while taking this kind of medication. Other side effects include dry mouth , blurred vision, constipation , difficulty with urination , confusion, and light-headedness. There

1170-429: The diagnosis of more sensitizations to this substance [Martin-Gorgojo & Johansen, 2013]. One study showed significantly increased sensitivity between 2005 and 2010 using 0.5% IPBC in patch tests [Warshaw et al., 2013b]. Allergen An allergen is an otherwise harmless substance that triggers an allergic reaction in sensitive individuals by stimulating an immune response . In technical terms, an allergen

1209-470: The genetic profiles of their citizens and different levels of exposure to specific foods, the official allergen lists will vary. Canada recognizes all nine of the allergens recognized by the US as well as mustard. The European Union additionally recognizes other gluten-containing cereals as well as celery and lupin . Another allergen is urushiol , a resin produced by poison ivy and poison oak , which causes

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1248-591: The high incidence of fungal sensitisation in individuals with suspected allergies. It has been found that of basidiomycete cap, mycelia, and spore extracts that spore extracts are the most reliable extract for diagnosing basidiomycete allergy. In Canada, 8% of children attending allergy clinics were found to be allergic to Ganoderma , a basidiospore. Pleurotus ostreatus , cladosporium , and Calvatia cyathiformis are significant airborne spores. Other significant fungal allergens include aspergillus and alternaria - penicillin families. In India Fomes pectinatus

1287-414: The results were negative." In addition, the study mentions two skin sensitivity studies on 183 children ages 3 – 12 yrs which showed no adverse effects as well as no significant irritation from IPBC. Since the early safety report, there have been a few reports of human skin sensitivity to IPBC in individual patients – all of which showed complete recovery after discontinuance of use of any product containing

1326-485: The same sensor proteins that evolved to detect proteases produced by the parasitic worms. Additionally, a new report on seasonal allergies called "Extreme allergies and Global Warming", have found that many allergy triggers are worsening due to climate change. 16 states in the United States were named as "Allergen Hotspots" for large increases in allergenic tree pollen if global warming pollution keeps increasing. Therefore, researchers on this report claimed that global warming

1365-450: The skin (subcutaneous). Immunotherapy contains a small amount of the substance that triggers the allergic reactions. Ladders are also used for egg and milk allergies as a home-based therapy mainly for children. Such methods cited in the UK involve the gradual introduction of the allergen in a cooked form where the protein allergenicity has been reduced to become less potent. By reintroducing

1404-443: The skin rash condition known as urushiol-induced contact dermatitis by changing a skin cell's configuration so that it is no longer recognized by the immune system as part of the body. Various trees and wood products such as paper, cardboard, MDF etc. can also cause mild to severe allergy symptoms through touch or inhalation of sawdust such as asthma and skin rash. An allergic reaction can be caused by any form of direct contact with

1443-450: The usage of the term "parasitic disease" is usually more restricted. The three main types of organisms causing these conditions are protozoa (causing protozoan infection ), helminths ( helminthiasis ), and ectoparasites . Protozoa and helminths are usually endoparasites (usually living inside the body of the host), while ectoparasites usually live on the surface of the host. Protozoa are single-celled, microscopic organisms that belong to

1482-455: The world. Use is restricted in some countries due to its toxicity, especially acute inhalation toxicity. IPBC is also becoming recognized as a contact allergen . IPBC is an effective fungicide at very low concentrations in cosmetic and other products, and has shown very low sensitivity in humans tested with this preservative. IPBC was approved in 1996 for use up to 0.1% concentrations in topical products and cosmetics. However, this preservative

1521-468: The year, usually during spring, summer or fall when certain trees or grasses pollinate. This depends on the kind of tree or grass. For instance, some trees such as oak , elm , and maple pollinate in the spring, while grasses such as Bermuda , timothy and orchard pollinate in the summer. Grass allergy is generally linked to hay fever because their symptoms and causes are somehow similar to each other. Symptoms include rhinitis , which causes sneezing and

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