119-459: A grape is a fruit , botanically a berry , of the deciduous woody vines of the flowering plant genus Vitis . Grapes are a non- climacteric type of fruit, generally occurring in clusters . The cultivation of grapes began approximately 8,000 years ago, and the fruit has been used as human food throughout its history. Eaten fresh or in dried form (as raisins , currants and sultanas ), grapes also hold cultural significance in many parts of
238-984: A fruit is a ripened ovary or carpel that contains seeds, e.g., an orange, pomegranate, tomato or a pumpkin. A nut is a type of fruit (and not a seed), and a seed is a ripened ovule . In culinary language, a fruit is the sweet- or not sweet- (even sour-) tasting produce of a specific plant (e.g., a peach, pear or lemon); nuts are hard, oily, non-sweet plant produce in shells ( hazelnut , acorn ). Vegetables , so-called, typically are savory or non-sweet produce ( zucchini , lettuce, broccoli, and tomato). but some may be sweet-tasting (sweet potato). Examples of botanically classified fruit that are typically called vegetables include cucumber , pumpkin , and squash (all are cucurbits ); beans , peanuts , and peas (all legumes ); and corn , eggplant , bell pepper (or sweet pepper), and tomato. Many spices are fruits, botanically speaking, including black pepper , chili pepper , cumin and allspice . In contrast, rhubarb
357-561: A risk factor for cardiovascular diseases . Fruit consumption is under preliminary research for the potential to improve nutrition and affect chronic diseases. Regular consumption of fruit is generally associated with reduced risks of several diseases and functional declines associated with aging. For food safety , the CDC recommends proper fruit handling and preparation to reduce the risk of food contamination and foodborne illness . Fresh fruits and vegetables should be carefully selected; at
476-746: A 12th-century document found in the Cairo Geniza . In Iran, a sour grape vinegar is used for making Shirazi salad . Winemaking from red and white grape flesh and skins produces substantial quantities of organic residues, collectively called pomace (also "marc"), which includes crushed skins, seeds, stems, and leaves generally used as compost . Grape pomace – some 10–30% of the total mass of grapes crushed – contains various phytochemicals , such as unfermented sugars, alcohol, polyphenols , tannins , anthocyanins , and numerous other compounds, some of which are harvested and extracted for commercial applications (a process sometimes called "valorization" of
595-450: A blackberry is an aggregate-accessory fruit, and an apple is a simple-accessory fruit. Seedlessness is an important feature of some fruits of commerce. Commercial cultivars of bananas and pineapples are examples of seedless fruits . Some cultivars of citrus fruits (especially grapefruit , mandarin oranges , navel oranges , satsumas ), table grapes , and of watermelons are valued for their seedlessness. In some species, seedlessness
714-614: A certain time, harmful bacteria may grow on them and increase the risk of foodborne illness. Vitamin K Vitamin K is a family of structurally similar, fat-soluble vitamers found in foods and marketed as dietary supplements . The human body requires vitamin K for post-synthesis modification of certain proteins that are required for blood coagulation ("K" from Danish koagulation , for "coagulation") or for controlling binding of calcium in bones and other tissues . The complete synthesis involves final modification of these so-called " Gla proteins " by
833-404: A coagulation assay, has been used as an indicator of vitamin K status, but it lacks sufficient sensitivity and specificity for this application. Serum phylloquinone is the most commonly used marker of vitamin K status. Concentrations <0.15 μg/L are indicative of deficiency. Disadvantages include exclusion of the other vitamin K vitamers and interference from recent dietary intake. Vitamin K
952-628: A consequence of exclusive breastfeeding, especially if there was no preventive treatment. Late onset prevalence reported at 35 cases per 100,000 live births in infants who had not received prophylaxis at or shortly after birth. Vitamin K deficiency bleeding occurs more frequently in the Asian population compared to the Caucasian population. Bleeding in infants due to vitamin K deficiency can be severe, leading to hospitalization, brain damage , and death. Intramuscular injection, typically given shortly after birth,
1071-468: A day for women and two for men, may confer health benefits. Alcohol itself may have protective effects on the cardiovascular system. The consumption of grapes and raisins presents a potential health threat to dogs. Their toxicity to dogs can cause the animal to develop acute kidney failure (the sudden development of kidney failure) with anuria (a lack of urine production) and may be fatal. Christians have traditionally used wine during worship services as
1190-713: A dietary supplement) but much lower when present in foods. For example, the absorption of vitamin K from kale and spinach – foods identified as having a high vitamin K content – are on the order of 4% to 17% regardless of whether raw or cooked. Less information is available for absorption of vitamin K 2 from foods. The intestinal membrane protein Niemann–Pick C1-like 1 (NPC1L1) mediates cholesterol absorption. Animal studies show that it also factors into absorption of vitamins E and K 1 . The same study predicts potential interaction between SR-BI and CD36 proteins as well. The drug ezetimibe inhibits NPC1L1 causing
1309-654: A dominant position of wine-making in human culture dates from 8,000 years ago in Georgia . The oldest known winery, the Areni-1 winery , was found in Armenia and dated back to around 4000 BC. By the 9th century AD, the city of Shiraz was known to produce some of the finest wines in the Middle East. Thus it has been proposed that Syrah red wine is named after Shiraz , a city in Persia where
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#17328489639701428-518: A head, is produced first. After fertilization , each flower in the cluster develops into a drupe; as the drupes expand, they develop as a connate organ, merging into a multiple fleshy fruit called a syncarp . Progressive stages of multiple flowering and fruit development can be observed on a single branch of the Indian mulberry, or noni . During the sequence of development, a progression of second, third, and more inflorescences are initiated in turn at
1547-528: A human dietary supplement because overdoses have been shown to cause allergic reactions , hemolytic anemia , and cytotoxicity in liver cells. 4-amino-2-methyl-1-naphthol ("K 5 ") is not natural and hence not a "vitamin". Research with "K 5 " suggests it may inhibit fungal growth in fruit juices. The structure of phylloquinone, Vitamin K 1 , is marked by the presence of a phytyl sidechain. Vitamin K 1 has an (E) trans double bond responsible for its biological activity, and two chiral centers on
1666-403: A jaundiced patient with prothrombin deficiency was made in 1938 by Smith, Warner, and Brinkhous. The precise function of vitamin K was not discovered until 1974, when prothrombin , a blood coagulation protein, was confirmed to be vitamin K dependent. When the vitamin is present, prothrombin has amino acids near the amino terminus of the protein as γ-carboxyglutamate instead of glutamate , and
1785-502: A means of remembering the blood of Jesus Christ which was shed for the remission of sins . Christians who oppose the partaking of alcoholic beverages sometimes use grape juice as the "cup" or "wine" in the Lord's Supper . The Catholic Church continues to use wine in the celebration of the Eucharist because it is part of the tradition passed down through the ages starting with Jesus Christ at
1904-568: A moderate amount of vitamin K (14% of the Daily Value ), with no other micronutrients in significant amounts. Most domesticated grapes come from cultivars of Vitis vinifera , a grapevine native to the Mediterranean and Central Asia. Minor amounts of fruit and wine come from American and Asian species such as: According to the Food and Agriculture Organization (FAO), 75,866 square kilometers of
2023-535: A multitude of products such as jams, juices, vinegars and oils. Commercially cultivated grapes are classified as either table or wine grapes. These categories are based on their intended method of consumption: grapes that are eaten raw (table grapes), or grapes that are used to make wine (wine grapes). Table grape cultivars normally have large, seedless fruit and thin skins. Wine grapes are smaller (in comparison to table grapes), usually contains seeds, and have thicker skins (a desirable characteristic in making wine). Most of
2142-644: A new plant some distance away from the parent. Other fruits have evolved flattened and elongated wings or helicopter-like blades, e.g., elm , maple , and tuliptree . This mechanism increases dispersal distance away from the parent via wind. Other wind-dispersed fruit have tiny " parachutes ", e.g., dandelion , milkweed , salsify . Coconut fruits can float thousands of miles in the ocean, thereby spreading their seeds. Other fruits that can disperse via water are nipa palm and screw pine . Some fruits have evolved propulsive mechanisms that fling seeds substantial distances – perhaps up to 100 m (330 ft) in
2261-680: A number of different forms from a wide range of families, including carrot , parsnip , parsley , cumin . An aggregate fruit is also called an aggregation, or etaerio ; it develops from a single flower that presents numerous simple pistils . Each pistil contains one carpel ; together, they form a fruitlet. The ultimate (fruiting) development of the aggregation of pistils is called an aggregate fruit , etaerio fruit , or simply an etaerio . Different types of aggregate fruits can produce different etaerios, such as achenes, drupelets, follicles, and berries. Some other broadly recognized species and their etaerios (or aggregations) are: The pistils of
2380-452: A number of related chemical subtypes, with differing lengths of carbon side chains made of isoprenoid groups of atoms. The two most studied are menaquinone-4 (MK-4) and menaquinone-7 (MK-7). Vitamin K 1 is made by plants, and is found in highest amounts in green leafy vegetables , being directly involved in photosynthesis . It is active as a vitamin in animals and performs the classic functions of vitamin K, including its activity in
2499-416: A prescription for a vitamin K antagonist drug, such as warfarin. A drug associated with increased risk of vitamin K deficiency is cefamandole , although the mechanism is unknown. Vitamin K is given as an injection to newborns to prevent vitamin K deficiency bleeding . The blood clotting factors of newborn babies are roughly 30–60% that of adult values; this appears to be a consequence of poor transfer of
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#17328489639702618-442: A prominent pointed terminal projection is said to be beaked . A fruit results from the fertilizing and maturing of one or more flowers. The gynoecium , which contains the stigma-style-ovary system, is centered in the flower-head, and it forms all or part of the fruit. Inside the ovary(ies) are one or more ovules . Here begins a complex sequence called double fertilization : a female gametophyte produces an egg cell for
2737-423: A reduction in cholesterol absorption in humans, and in animal studies, also reduces vitamin E and vitamin K 1 absorption. An expected consequence would be that administration of ezetimibe to people who take warfarin (a vitamin K antagonist) would potentiate the warfarin effect. This has been confirmed in humans. Vitamin K is distributed differently within animals depending on its specific homologue. Vitamin K 1
2856-451: A relatively high phenolic content among dark grapes. In muscadine skins, ellagic acid , myricetin , quercetin , kaempferol , and trans-resveratrol are major phenolics. The flavonols syringetin , syringetin 3-O-galactoside, laricitrin and laricitrin 3-O-galactoside are also found in purple grape but absent in white grape. Muscadine grape seeds contain about twice the total polyphenol content of skins. Grape seed oil from crushed seeds
2975-626: A seeded variety as the female parent or rescue embryos early in development using tissue culture techniques. There are several sources of the seedlessness trait, and essentially all commercial cultivators get it from one of three sources: Thompson Seedless , Russian Seedless , and Black Monukka , all being cultivars of Vitis vinifera . There are currently more than a dozen varieties of seedless grapes. Several, such as Einset Seedless, Benjamin Gunnels's Prime seedless grapes, Reliance, and Venus, have been specifically cultivated for hardiness and quality in
3094-404: A single flower with numerous pistils typically produces an aggregate fruit ; and the merging of several flowers, or a 'multiple' of flowers, results in a 'multiple' fruit. A simple fruit is further classified as either dry or fleshy. To distribute their seeds, dry fruits may split open and discharge their seeds to the winds, which is called dehiscence . Or the distribution process may rely upon
3213-415: A small molecule with an excess of electrons (also called an electron donor) such as lactate , formate , or NADH , with the help of an enzyme, passes two electrons to menaquinone. The menaquinone, with the help of another enzyme, then transfers these two electrons to a suitable oxidant, such as fumarate or nitrate (also called an electron acceptor). Adding two electrons to fumarate or nitrate converts
3332-425: A source of vitamin K 2 . The MK-4 form is from conversion of plant-sourced vitamin K 1 in various tissues in the body. Because vitamin K aids mechanisms for blood clotting, its deficiency may lead to reduced blood clotting, and in severe cases, can result in reduced clotting, increased bleeding, and increased prothrombin time . Normal diets are usually not deficient in vitamin K, indicating that deficiency
3451-454: A team of archaeologists concluded that Chalcolithic wine jars discovered in Cyprus in the 1930s dated back to 3500 BC, making them the oldest of their kind in the world. Commandaria , a sweet dessert wine from Cyprus, is the oldest manufactured wine in the world with origins as far back as 2000 BC. In North America, native grapes belonging to various species of the genus Vitis proliferate in
3570-497: A wide variety of vertebrates: mammals, birds, reptiles, and fish. The venom of a number of Australian snakes acts by activating the human blood-clotting system. In some cases, activation is accomplished by snake Gla-containing enzymes that bind to the endothelium of human blood vessels and catalyze the conversion of procoagulant clotting factors into activated ones, leading to unwanted and potentially deadly clotting. Another interesting class of invertebrate Gla-containing proteins
3689-493: Is 90 μg/day, and for lactation is 90 μg/day. For infants up to 12 months, the AI is 2.0–2.5 μg/day; for children ages 1–18 years the AI increases with age from 30 to 75 μg/day. As for safety, the academy sets tolerable upper intake levels (known as "upper limits") for vitamins and minerals when evidence is sufficient. Vitamin K has no upper limit, as human data for adverse effects from high doses are not sufficient. In
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3808-508: Is a somewhat uncommon posttranslational modification of the protein, which is then known as a "Gla protein" . The presence of two −COOH (carboxylic acid) groups on the same carbon in the gamma-carboxyglutamate residue allows it to chelate calcium ions . The binding of calcium ions in this way very often triggers the function or binding of Gla-protein enzymes, such as the so-called vitamin K–dependent clotting factors discussed below. Within
3927-541: Is a vitamin K-dependent protein found in bone, but also in soft tissues such as arteries, where it appears to function as an anti-calcification protein. In animal studies, animals that lack the gene for MGP exhibit calcification of arteries and other soft tissues. In humans, Keutel syndrome is a rare recessive genetic disorder associated with abnormalities in the gene coding for MGP and characterized by abnormal diffuse cartilage calcification . These observations led to
4046-432: Is able to bind calcium, part of the clotting process. Vitamin K is required for the gamma-carboxylation of osteocalcin in bone. The risk of osteoporosis , assessed via bone mineral density and fractures, was not affected for people on warfarin therapy – a vitamin K antagonist. Studies investigating whether vitamin K supplementation reduces risk of bone fractures have shown mixed results. Matrix Gla protein
4165-701: Is believed that the most widely planted variety is Sultana , also known as Thompson Seedless, with at least 3,600 km (880,000 acres) dedicated to it. The second most common variety is Airén . Other popular varieties include Cabernet Sauvignon , Sauvignon blanc , Cabernet Franc , Merlot , Grenache , Tempranillo , Riesling , and Chardonnay . Commercially cultivated grapes can usually be classified as either table or wine grapes, based on their intended method of consumption: eaten raw (table grapes) or used to make wine (wine grapes). The sweetness of grapes depends on when they are harvested, as they do not continue to ripen once picked. While almost all of them belong to
4284-445: Is continuously recycled in cells. Warfarin and other 4-hydroxycoumarins block the action of VKOR. This results in decreased concentrations of vitamin K and vitamin K hydroquinone in tissues, such that the carboxylation reaction catalyzed by the glutamyl carboxylase is inefficient. This results in the production of clotting factors with inadequate Gla. Without Gla on the amino termini of these factors, they no longer bind stably to
4403-451: Is described as a nonimmune-mediated anaphylactoid reaction , with incidence of 3 per 10,000 treatments. The majority of reactions occurred when polyoxyethylated castor oil was used as the solubilizing agent. Menadione, a natural compound sometimes referred to as vitamin K 3 , is used in the pet food industry because once consumed it is converted to vitamin K 2 . The US Food and Drug Administration has banned this form from sale as
4522-547: Is evidence that the conversion proceeds by removal of the phytyl tail of K 1 to produce menadione (also referred to as vitamin K 3 ) as an intermediate, which is then prenylated to produce MK-4. In animals, vitamin K is involved in the carboxylation of certain glutamate residues in proteins to form gamma-carboxyglutamate (Gla) residues. The modified residues are often (but not always) situated within specific protein domains called Gla domains . Gla residues are usually involved in binding calcium , and are essential for
4641-473: Is found in large quantities in the photosynthetic tissues of plants (green leaves , and dark green leafy vegetables such as romaine lettuce , kale , and spinach ), but it occurs in far smaller quantities in other plant tissues. Detection of VKORC1 homologues active on the K 1 -epioxide suggest that K 1 may have a non-redox function in these organisms. In plants but not cyanobacteria, knockout of this gene show growth restriction similar to mutants lacking
4760-435: Is indicative of vitamin K deficiency. No known toxicity is associated with high oral doses of the vitamin K 1 or vitamin K 2 forms of vitamin K, so regulatory agencies from US, Japan and European Union concur that no tolerable upper intake levels needs to be set. However, vitamin K 1 has been associated with severe adverse reactions such as bronchospasm and cardiac arrest when given intravenously. The reaction
4879-400: Is mainly present in the liver, heart and pancreas, while MK-4 is better represented in the kidneys, brain and pancreas. The liver also contains longer chain homologues MK-7 to MK-13. The function of vitamin K 2 in the animal cell is to add a carboxylic acid functional group to a glutamate (Glu) amino acid residue in a protein , to form a gamma-carboxyglutamate (Gla) residue. This
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4998-456: Is more effective in preventing vitamin K deficiency bleeding than oral administration, which calls for weekly dosing up to three months of age. Warfarin is an anticoagulant drug. It functions by inhibiting an enzyme that is responsible for recycling vitamin K to a functional state. As a consequence, proteins that should be modified by vitamin K are not, including proteins essential to blood clotting, and are thus not functional. The purpose of
5117-417: Is often called a fruit when used in making pies , but the edible produce of rhubarb is actually the leaf stalk or petiole of the plant. Edible gymnosperm seeds are often given fruit names, e.g., ginkgo nuts and pine nuts . Botanically, a cereal grain, such as corn , rice , or wheat is a kind of fruit (termed a caryopsis ). However, the fruit wall is thin and fused to the seed coat, so almost all
5236-810: Is pressed for olive oil and similar processing is applied to other oil-bearing fruits and vegetables. Some fruits are available all year round, while others (such as blackberries and apricots in the UK) are subject to seasonal availability. Fruits are also used for socializing and gift-giving in the form of fruit baskets and fruit bouquets . Typically, many botanical fruits – "vegetables" in culinary parlance – (including tomato, green beans, leaf greens, bell pepper, cucumber, eggplant, okra, pumpkin, squash, zucchini) are bought and sold daily in fresh produce markets and greengroceries and carried back to kitchens, at home or restaurant, for preparation of meals. All fruits benefit from proper post-harvest care, and in many fruits,
5355-432: Is primarily from plants, especially leafy green vegetables. Small amounts are provided by animal-sourced foods. Vitamin K 2 is primarily from animal-sourced foods, with poultry and eggs much better sources than beef, pork or fish. One exception to the latter is nattō , which is made from bacteria-fermented soybeans. It is a rich food source of vitamin K 2 variant MK-7, made by the bacteria. Animal-sourced foods are
5474-479: Is required for the gamma-carboxylation of specific glutamic acid residues within the Gla domain of the 17 vitamin K–dependent proteins. Thus, a rise in uncarboxylated versions of these proteins is an indirect but sensitive and specific marker for vitamin K deficiency. If uncarboxylated prothrombin is being measured, this "Protein induced by Vitamin K Absence/antagonism (PIVKA-II)" is elevated in vitamin K deficiency. The test
5593-505: Is seriously impaired, and uncontrolled bleeding occurs. Research suggests that deficiency of vitamin K may also weaken bones, potentially contributing to osteoporosis , and may promote calcification of arteries and other soft tissues. Chemically, the vitamin K family comprises 2- methyl - 1,4-naphthoquinone (3-) derivatives . Vitamin K includes two natural vitamers: vitamin K 1 ( phylloquinone ) and vitamin K 2 ( menaquinone ). Vitamin K 2 , in turn, consists of
5712-551: Is synthesized by the fish-hunting snail Conus geographus . These snails produce a venom containing hundreds of neuroactive peptides , or conotoxins , which is sufficiently toxic to kill an adult human. Several of the conotoxins contain two to five Gla residues. Vitamin K 1 is an important chemical in green plants (including land plants and green algae) and some species of cyanobacteria , where it functions as an electron acceptor transferring one electron in photosystem I during photosynthesis . For this reason, vitamin K 1
5831-435: Is the means for seed dispersal for the one group and nutrition for the other; humans, and many other animals, have become dependent on fruits as a source of food. Consequently, fruits account for a substantial fraction of the world's agricultural output, and some (such as the apple and the pomegranate ) have acquired extensive cultural and symbolic meanings. In common language and culinary usage, fruit normally means
5950-522: Is the result of parthenocarpy , where fruits set without fertilization. Parthenocarpic fruit-set may (or may not) require pollination, but most seedless citrus fruits require a stimulus from pollination to produce fruit. Seedless bananas and grapes are triploids , and seedlessness results from the abortion of the embryonic plant that is produced by fertilization, a phenomenon known as stenospermocarpy , which requires normal pollination and fertilization. Variations in fruit structures largely depend on
6069-463: Is to avoid those (examples: collard greens, spinach, turnip greens) entirely, and for foods with a modestly high vitamin content, keep consumption as consistent as possible, so that the combination of vitamin intake and warfarin keep the anti-clotting activity in the therapeutic range. Vitamin K is a treatment for bleeding events caused by overdose of the drug. The vitamin can be administered by mouth, intravenously or subcutaneously . Oral vitamin K
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#17328489639706188-576: Is uncommon in healthy children and adults. An exception may be infants who are at an increased risk of deficiency regardless of the vitamin status of the mother during pregnancy and breast feeding due to poor transfer of the vitamin to the placenta and low amounts of the vitamin in breast milk. Secondary deficiencies can occur in people who consume adequate amounts, but have malabsorption conditions, such as cystic fibrosis or chronic pancreatitis, and in people who have liver damage or disease . Secondary vitamin K deficiency can also occur in people who have
6307-687: Is used in cosmeceuticals and skincare products. Grape seed oil, including tocopherols ( vitamin E ) and high contents of phytosterols and polyunsaturated fatty acids such as linoleic acid , oleic acid , and alpha-linolenic acid . Resveratrol, a stilbene compound, is found in widely varying amounts among grape varieties, primarily in their skins and seeds. Muscadine grapes have about one hundred times higher concentration of stilbenes than pulp. Fresh grape skin contains about 50 to 100 micrograms of resveratrol per gram. Comparing diets among Western countries, researchers have discovered that, although French people tend to eat higher levels of animal fat,
6426-450: Is used in situations when a person's International normalized ratio is greater than 10 but there is no active bleeding. The newer anticoagulants apixaban , dabigatran and rivaroxaban are not vitamin K antagonists. Coumarin is used in the pharmaceutical industry as a precursor reagent in the synthesis of a number of synthetic anticoagulant pharmaceuticals. One subset, 4-hydroxycoumarins , act as vitamin K antagonists . They block
6545-597: Is used to assess risk of vitamin K–deficient bleeding in newborn infants. Osteocalcin is involved in calcification of bone tissue. The ratio of uncarboxylated osteocalcin to carboxylated osteocalcin increases with vitamin K deficiency. Vitamin K2 has been shown to lower this ratio and improve lumbar vertebrae bone mineral density . Matrix Gla protein must undergo vitamin K dependent phosphorylation and carboxylation. Elevated plasma concentration of dephosphorylated, uncarboxylated MGP
6664-505: The pericarp (fruit wall) is fleshy at maturity are termed fleshy simple fruits . Types of fleshy simple fruits, (with examples) include: Berries are a type of simple fleshy fruit that issue from a single ovary. (The ovary itself may be compound, with several carpels.) The botanical term true berry includes grapes, currants, cucumbers, eggplants (aubergines), tomatoes, chili peppers, and bananas, but excludes certain fruits that are called "-berry" by culinary custom or by common usage of
6783-534: The Last Supper , where Catholics believe the consecrated bread and wine become the body and blood of Jesus Christ, a dogma known as transubstantiation . Wine is used (not grape juice) both due to its strong Scriptural roots, and also to follow the tradition set by the early Christian Church. The Code of Canon Law of the Catholic Church (1983), Canon 924 says that the wine used must be natural, made from grapes of
6902-603: The modes of dispersal applied to their seeds. Dispersal is achieved by wind or water, by explosive dehiscence , and by interactions with animals. Some fruits present their outer skins or shells coated with spikes or hooked burrs; these evolved either to deter would-be foragers from feeding on them or to serve to attach themselves to the hair, feathers, legs, or clothing of animals, thereby using them as dispersal agents. These plants are termed zoochorous ; common examples include cocklebur , unicorn plant , and beggarticks (or Spanish needle) . By developments of mutual evolution,
7021-434: The raspberry are called drupelets because each pistil is like a small drupe attached to the receptacle. In some bramble fruits, such as blackberry , the receptacle, an accessory part, elongates and then develops as part of the fruit, making the blackberry an aggregate-accessory fruit. The strawberry is also an aggregate-accessory fruit, of which the seeds are contained in the achenes . Notably in all these examples,
7140-465: The wine industry, grape juice that contains 7–23% of pulp, skins, stems and seeds is often referred to as " must ". In North America, the most common grape juice is purple and made from Concord grapes , while white grape juice is commonly made from Niagara grapes , both of which are varieties of native American grapes, a different species from European wine grapes. In California, Sultana (known there as Thompson Seedless) grapes are sometimes diverted from
7259-412: The (deposited) pollen through the stigma down the style into the ovary to the ovule. Two sperm are transferred from the pollen to a megagametophyte. Within the megagametophyte, one sperm unites with the egg, forming a zygote , while the second sperm enters the central cell forming the endosperm mother cell, which completes the double fertilization process. Later, the zygote will give rise to the embryo of
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#17328489639707378-547: The EU to use the term "dried vine fruit" in official documents. A raisin is any dried grape. While raisin is a French loanword , the word in French refers to the fresh fruit; grappe (from which the English grape is derived) refers to the bunch (as in une grappe de raisins ). A raisin in French is called raisin sec ("dry grape"). A currant is a dried Zante Black Corinth grape,
7497-585: The European Union, adequate intake is defined the same way as in the US. For women and men over age 18 the adequate intake is set at 70 μg/day, for pregnancy 70 μg/day, and for lactation 70 μg/day. For children ages 1–17 years, adequate intake values increase with age from 12 to 65 μg/day. Japan set adequate intakes for adult women at 65 μg/day and for men at 75 μg/day. The European Union and Japan also reviewed safety and concluded – as had
7616-506: The United States ;– that there was insufficient evidence to set an upper limit for vitamin K. For US food and dietary supplement labeling purposes, the amount in a serving is expressed as a percentage of daily value. For vitamin K labeling purposes, 100% of the daily value was 80 μg, but on 27 May 2016 it was revised upwards to 120 μg, to bring it into agreement with the highest value for adequate intake. Compliance with
7735-531: The United States), but the word is now applied to raisins made from either white grapes or red grapes that are bleached to resemble the traditional sultana. Grape juice is obtained from crushing and blending grapes into a liquid. The juice is often sold in stores or fermented and made into wine , brandy , or vinegar . Grape juice that has been pasteurized, removing any naturally occurring yeast, will not ferment if kept sterile, and thus contains no alcohol. In
7854-413: The ability to produce K 1 . Many bacteria, including Escherichia coli found in the large intestine , can synthesize vitamin K 2 (MK-7 up to MK-11), but not vitamin K 1 . In the vitamin K 2 synthesizing bacteria, menaquinone transfers two electrons between two different small molecules, during oxygen-independent metabolic energy production processes ( anaerobic respiration ). For example,
7973-491: The aroma in wine is from the skin. Wine grapes tend to have a high sugar content. They are harvested at peak sugar levels (approximately 24% sugar by weight.) In comparison, commercially produced "100% grape juice" made from table grapes are normally around 15% sugar by weight. In most of Europe and North America, dried grapes are referred to as "raisins" or the local equivalent. In the UK, three different varieties are recognized, forcing
8092-408: The attachment of other floral parts – there are parts (including petals, sepals, and stamens) that fuse with the ovary and ripen with it. For such a case, when floral parts other than the ovary form a significant part of the fruit that develops, it is called an accessory fruit . Examples of accessory fruits include apple, rose hip, strawberry, and pineapple. Because several parts of the flower besides
8211-410: The biological activity of all known Gla proteins. 17 human proteins with Gla domains have been discovered; they play key roles in the regulation of three physiological processes: Vitamin K is absorbed through the jejunum and ileum in the small intestine . The process requires bile and pancreatic juices . Estimates for absorption are on the order of 80% for vitamin K 1 in its free form (as
8330-531: The blood vessel endothelium and cannot activate clotting to allow formation of a clot during tissue injury. As it is impossible to predict what dose of warfarin will give the desired degree of clotting suppression, warfarin treatment must be carefully monitored to avoid underdose and overdose. The following human Gla-containing proteins ("Gla proteins") have been characterized to the level of primary structure: blood coagulation factors II ( prothrombin ), VII, IX, and X, anticoagulant protein C and protein S , and
8449-421: The carboxylase enzyme is able to oxidize vitamin K hydroquinone to vitamin K epoxide at the same time. The carboxylation and epoxidation reactions are said to be coupled. Vitamin K epoxide is then restored to vitamin K by VKOR. The reduction and subsequent reoxidation of vitamin K coupled with carboxylation of Glu is called the vitamin K cycle. Humans are rarely deficient in vitamin K because, in part, vitamin K 2
8568-890: The case of the sandbox tree – via explosive dehiscence or other such mechanisms (see impatiens and squirting cucumber ). A cornucopia of fruits – fleshy (simple) fruits from apples to berries to watermelon; dry (simple) fruits including beans and rice and coconuts; aggregate fruits including strawberries, raspberries, blackberries, pawpaw; and multiple fruits such as pineapple, fig, mulberries – are commercially valuable as human food. They are eaten both fresh and as jams, marmalade and other fruit preserves . They are used extensively in manufactured and processed foods (cakes, cookies, baked goods, flavorings, ice cream, yogurt, canned vegetables, frozen vegetables and meals) and beverages such as fruit juices and alcoholic beverages (brandy, fruit beer , wine). Spices like vanilla, black pepper, paprika, and allspice are derived from berries. Olive fruit
8687-445: The cell, vitamin K participates in a cyclic process. The vitamin undergoes electron reduction to a reduced form called vitamin K hydroquinone (quinol), catalyzed by the enzyme vitamin K epoxide reductase (VKOR). Another enzyme then oxidizes vitamin K hydroquinone to allow carboxylation of Glu to Gla; this enzyme is called gamma-glutamyl carboxylase or the vitamin K–dependent carboxylase. The carboxylation reaction only proceeds if
8806-490: The decay and degradation of the fruit to expose the seeds; or it may rely upon the eating of fruit and excreting of seeds by frugivores – both are called indehiscence . Fleshy fruits do not split open, but they also are indehiscent and they may also rely on frugivores for distribution of their seeds. Typically, the entire outer layer of the ovary wall ripens into a potentially edible pericarp . Types of dry simple fruits, (with examples) include: Fruits in which part or all of
8925-418: The diet. It appeared that – together with the cholesterol – a second compound was extracted from the food, and this compound was called the coagulation vitamin. The new vitamin received the letter K because the initial discoveries were reported in a German journal, in which it was designated as Koagulationsvitamin . Edward Adelbert Doisy of Saint Louis University did much of the research that led to
9044-570: The discovery of the structure and chemical nature of vitamin K. Dam and Doisy shared the 1943 Nobel Prize for medicine for their work on vitamin K 1 and K 2 published in 1939. Several laboratories synthesized the compound(s) in 1939. For several decades, the vitamin K–deficient chick model was the only method of quantifying vitamin K in various foods: the chicks were made vitamin K–deficient and subsequently fed with known amounts of vitamin K–containing food. The extent to which blood coagulation
9163-407: The drug is to reduce risk of inappropriate blood clotting, which can have serious, potentially fatal consequences. The proper anticoagulant action of warfarin is a function of vitamin K intake and drug dose. Due to differing absorption of the drug and amounts of vitamin K in the diet, dosing must be monitored and customized for each patient. Some foods are so high in vitamin K 1 that medical advice
9282-401: The edible grain-fruit is actually a seed. The outer layer, often edible, of most fruits is called the pericarp . Typically formed from the ovary, it surrounds the seeds; in some species, however, other structural tissues contribute to or form the edible portion. The pericarp may be described in three layers from outer to inner, i.e., the epicarp , mesocarp and endocarp . Fruit that bears
9401-478: The enzyme gamma-glutamyl carboxylase that uses vitamin K as a cofactor . Vitamin K is used in the liver as the intermediate VKH 2 to deprotonate a glutamate residue and then is reprocessed into vitamin K through a vitamin K oxide intermediate. The presence of uncarboxylated proteins indicates a vitamin K deficiency . Carboxylation allows them to bind ( chelate ) calcium ions, which they cannot do otherwise. Without vitamin K, blood coagulation
9520-507: The factor X-targeting protein Z . The bone Gla protein osteocalcin , the calcification-inhibiting matrix Gla protein (MGP), the cell growth regulating growth arrest specific gene 6 protein, and the four transmembrane Gla proteins, the function of which is at present unknown. The Gla domain is responsible for high-affinity binding of calcium ions (Ca ) to Gla proteins, which is often necessary for their conformation, and always necessary for their function. Gla proteins are known to occur in
9639-477: The fleshy produce of fruits typically appeals to hungry animals, such that the seeds contained within are taken in, carried away, and later deposited (i.e., defecated ) at a distance from the parent plant. Likewise, the nutritious, oily kernels of nuts typically motivate birds and squirrels to hoard them, burying them in soil to retrieve later during the winter of scarcity; thereby, uneaten seeds are sown effectively under natural conditions to germinate and grow
9758-429: The fruit develops from a single flower, with numerous pistils. A multiple fruit is formed from a cluster of flowers, (a 'multiple' of flowers) – also called an inflorescence . Each ('smallish') flower produces a single fruitlet, which, as all develop, all merge into one mass of fruit. Examples include pineapple , fig , mulberry , Osage orange , and breadfruit . An inflorescence (a cluster) of white flowers, called
9877-416: The fruits develop, but they are not evolutionarily relevant as diverse plant taxa may be in the same group. While the section of a fungus that produces spores is called a fruiting body, fungi are members of the fungi kingdom and not of the plant kingdom . Simple fruits are the result of the ripening-to-fruit of a simple or compound ovary in a single flower with a single pistil . In contrast,
9996-433: The function of glutathione , it is no longer used in this manner in human nutrition. Vitamin K refers to structurally similar, fat-soluble vitamers found in foods and marketed as dietary supplements. "Vitamin K" include several chemical compounds. These are similar in structure in that they share a quinone ring, but differ in the length and degree of saturation of the carbon tail and the number of repeating isoprene units in
10115-508: The grape was used to make Shirazi wine . Ancient Egyptian hieroglyphics record the cultivation of purple grapes, and history attests to the ancient Greeks , Cypriots , Phoenicians , and Romans growing purple grapes both for eating and wine production. The growing of grapes would later spread to other regions in Europe, as well as North Africa, and eventually in North America . In 2005,
10234-419: The head of the branch or stem. Fruits may incorporate tissues derived from other floral parts besides the ovary, including the receptacle, hypanthium, petals, or sepals. Accessory fruits occur in all three classes of fruit development – simple, aggregate, and multiple. Accessory fruits are frequently designated by the hyphenated term showing both characters. For example, a pineapple is a multiple-accessory fruit,
10353-606: The incidence of heart disease remains low in France. This phenomenon has been termed the French paradox and is thought to occur due to the protective benefits of regularly consuming red wine, among other dietary practices. Alcohol consumption in moderation may be cardioprotective by its minor anticoagulant effect and vasodilation . Although adoption of wine consumption is generally not recommended by health authorities, some research indicates moderate consumption, such as one glass of red wine
10472-496: The latter term meaning the fleshy part is derived not from the plant's ovaries but from the receptacle that holds the ovaries . Numerous dry achenes are attached to the outside of the fruit-flesh; they appear to be seeds but each is actually an ovary of a flower, with a seed inside. Schizocarps are dry fruits, though some appear to be fleshy. They originate from syncarpous ovaries but do not actually dehisce ; rather, they split into segments with one or more seeds. They include
10591-638: The molecule to succinate or nitrite plus water , respectively. Some of these reactions generate a cellular energy source, ATP , in a manner similar to eukaryotic cell aerobic respiration , except the final electron acceptor is not molecular oxygen , but fumarate or nitrate . In aerobic respiration , the final oxidant is molecular oxygen , which accepts four electrons from an electron donor such as NADH to be converted to water . E. coli , as facultative anaerobes , can carry out both aerobic respiration and menaquinone-mediated anaerobic respiration. In 1929, Danish scientist Henrik Dam investigated
10710-469: The name being a corruption of the French raisin de Corinthe ( Corinth grape). The names of the black and red currant, now more usually blackcurrant and redcurrant , two berries unrelated to grapes, are derived from this use. Some other fruits of similar appearance are also so named, for example, Australian currant, native currant, Indian currant. A sultana was originally a raisin made from Sultana grapes of Turkish origin (known as Thompson Seedless in
10829-470: The naphthoquinone ring base and the alkyl side chain. In animals, the MK-4 form of vitamin K 2 is produced by conversion of vitamin K 1 in the testes , pancreas , and arterial walls. While major questions still surround the biochemical pathway for this transformation, the conversion is not dependent on gut bacteria , as it occurs in germ-free rats and in parenterally administered K 1 in rats. There
10948-445: The number of fertilized ovules. The pericarp typically is differentiated into two or three distinct layers; these are called the exocarp (outer layer, also called epicarp), mesocarp (middle layer), and endocarp (inner layer). In some fruits, the sepals , petals , stamens or the style of the flower fall away as the fleshy fruit ripens. However, for simple fruits derived from an inferior ovary – i.e., one that lies below
11067-437: The ovary may contribute to the structure of a fruit, it is important to understand how a particular fruit forms. There are three general modes of fruit development: Consistent with the three modes of fruit development, plant scientists have classified fruits into three main groups: simple fruits, aggregate fruits, and multiple (or composite) fruits. The groupings reflect how the ovary and other flower organs are arranged and how
11186-568: The phytyl sidechain. Vitamin K 1 appears as a yellow viscous liquid at room temperature due to its absorption of violet light in the UV-visible spectra obtained by ultraviolet–visible spectroscopy . The structures of menaquinones, vitamin K 2 , are marked by the polyisoprenyl side chain present in the molecule that can contain four to 13 isoprenyl units. MK-4 is the most common form. The large size of Vitamin K 1 gives many different peaks in mass spectroscopy, most of which involve derivatives of
11305-614: The plant hormone ethylene causes ripening . Therefore, maintaining most fruits in an efficient cold chain is optimal for post-harvest storage, with the aim of extending and ensuring shelf life. Various culinary fruits provide significant amounts of fiber and water, and many are generally high in vitamin C . An overview of numerous studies showed that fruits (e.g., whole apples or whole oranges) are satisfying (filling) by simply eating and chewing them. The dietary fiber consumed in eating fruit promotes satiety , and may help to control body weight and aid reduction of blood cholesterol ,
11424-570: The pomace). Anthocyanins tend to be the main polyphenolics in purple grapes, whereas flavan-3-ols (i.e. catechins ) are the more abundant class of polyphenols in white varieties. Total phenolic content is higher in purple varieties due almost entirely to anthocyanin density in purple grape skin compared to absence of anthocyanins in white grape skin. Phenolic content of grape skin varies with cultivar , soil composition, climate, geographic origin, and cultivation practices or exposure to diseases, such as fungal infections. Muscadine grapes contain
11543-425: The production of blood-clotting proteins. Animals may also convert it to vitamin K 2 , variant MK-4. Bacteria in the gut flora can also convert K 1 into K 2 . All forms of K 2 other than MK-4 can only be produced by bacteria, which use these during anaerobic respiration . Vitamin K 3 ( menadione ), a synthetic form of vitamin K, was used to treat vitamin K deficiency, but because it interferes with
11662-630: The purple grape. Mutations in two regulatory genes of white grapes turn off production of anthocyanins , which are responsible for the color of purple grapes. Anthocyanins and other pigment chemicals of the larger family of polyphenols in purple grapes are responsible for the varying shades of purple in red wines. Grapes are typically an ellipsoid shape resembling a prolate spheroid . Raw grapes are 81% water, 18% carbohydrates , 1% protein , and have negligible fat (table). A 100-gram ( 3 + 1 ⁄ 2 -ounce) reference amount of raw grapes supplies 288 kilojoules (69 kilocalories) of food energy and
11781-401: The purpose of fertilization. (A female gametophyte is called a megagametophyte , and also called the embryo sac .) After double fertilization, the ovules will become seeds. Ovules are fertilized in a process that starts with pollination , which is the movement of pollen from the stamens to the stigma-style-ovary system within the flower-head. After pollination, a pollen tube grows from
11900-496: The raisin or table market to produce white juice. Husrum , also known as verjuice , is a type of vinegar made from sour grapes in the Middle East. It is produced by crushing unripened grapes, collecting and salting the juice, simmering it to remove foam, and then storing it with a layer of olive oil to prevent contamination and oxidation. It is then used as an acidic ingredient in salads and stuffed vegetables. Unripened husrum grapes sent from Ashkelon to Egypt are mentioned in
12019-412: The regeneration and recycling of vitamin K. Some of the 4-hydroxycoumarin anticoagulant class of chemicals are designed to have high potency and long residence times in the body, and these are used specifically as second generation rodenticides ("rat poison"). Death occurs after a period of several days to two weeks, usually from internal hemorrhaging. For humans, and for animals that have consumed either
12138-449: The relatively cold climates of northeastern United States and southern Ontario . An offset to the improved eating quality of seedlessness is the loss of potential health benefits provided by the enriched phytochemical content of grape seeds (see Health claims , below). Grapes are eaten raw, dried (as raisins, currants and sultanas), or cooked. Also, depending on grape cultivar, grapes are used in winemaking. Grapes can be processed into
12257-421: The rodenticide or rats poisoned by the rodenticide, treatment is prolonged administration of large amounts of vitamin K. This dosing must sometimes be continued for up to nine months in cases of poisoning by " superwarfarin " rodenticides such as brodifacoum . Oral vitamin K 1 is preferred over other vitamin K 1 routes of administration because it has fewer side effects. An increase in prothrombin time ,
12376-570: The role of cholesterol by feeding chickens a cholesterol-depleted diet. He initially replicated experiments reported by scientists at the Ontario Agricultural College . McFarlane, Graham and Richardson, working on the chick feed program at OAC, used chloroform to remove all fat from chick chow. They noticed that chicks fed only fat-depleted chow developed hemorrhages and started bleeding from tag sites. Dam found that these defects could not be restored by adding purified cholesterol to
12495-461: The same species, Vitis vinifera , table and wine grapes have significant differences, brought about through selective breeding . Table grape cultivars tend to have large, seedless fruit (see below) with relatively thin skin. Wine grapes are smaller, usually seeded, and have relatively thick skins (a desirable characteristic in winemaking, since much of the aroma in wine comes from the skin). Wine grapes also tend to be very sweet: they are harvested at
12614-401: The seed, and the endosperm mother cell will give rise to endosperm , a nutritive tissue used by the embryo. As the ovules develop into seeds, the ovary begins to ripen and the ovary wall, the pericarp , may become fleshy (as in berries or drupes ), or it may form a hard outer covering (as in nuts). In some multi-seeded fruits, the extent to which a fleshy structure develops is proportional to
12733-504: The seed-associated fleshy structures (or produce) of plants that typically are sweet (or sour) and edible in the raw state, such as apples, bananas, grapes, lemons, oranges, and strawberries. In botanical usage, the term fruit also includes many structures that are not commonly called as such in everyday language, such as nuts, bean pods, corn kernels, tomatoes, and wheat grains. Many common language terms used for fruit and seeds differ from botanical classifications. For example, in botany,
12852-632: The side chain (see figures in Chemistry section). Plant-sourced forms are primarily vitamin K 1 . Animal-sourced foods are primarily vitamin K 2 . Vitamin K has several roles: an essential nutrient absorbed from food, a product synthesized and marketed as part of a multi-vitamin or as a single-vitamin dietary supplement, and a prescription medication for specific purposes. The US National Academy of Medicine does not distinguish between K 1 and K 2 – both are counted as vitamin K. When recommendations were last updated in 1998, sufficient information
12971-730: The store, they should not be damaged or bruised; and precut pieces should be refrigerated or surrounded by ice. All fruits and vegetables should be rinsed before eating. This recommendation also applies to produce with rinds or skins that are not eaten. It should be done just before preparing or eating to avoid premature spoilage. Fruits and vegetables should be kept separate from raw foods like meat, poultry, and seafood, as well as from utensils that have come in contact with raw foods. Fruits and vegetables that are not going to be cooked should be thrown away if they have touched raw meat, poultry, seafood, or eggs. All cut, peeled, or cooked fruits and vegetables should be refrigerated within two hours. After
13090-417: The term – such as strawberries and raspberries. Berries may be formed from one or more carpels (i.e., from the simple or compound ovary) from the same, single flower. Seeds typically are embedded in the fleshy interior of the ovary. Examples include: The strawberry, regardless of its appearance, is classified as a dry, not a fleshy fruit. Botanically, it is not a berry ; it is an aggregate-accessory fruit,
13209-442: The time when their juice is approximately 24% sugar by weight. By comparison, commercially produced "100% grape juice", made from table grapes, is usually around 15% sugar by weight. Seedless cultivars now make up the overwhelming majority of table grape plantings. Because grapevines are vegetatively propagated by cuttings, the lack of seeds does not present a problem for reproduction. It is an issue for breeders, who must either use
13328-619: The updated labeling regulations was required by 1 January 2020 for manufacturers with US$ 10 million or more in annual food sales, and by 1 January 2021 for manufacturers with lower volume food sales. A table of the old and new adult daily values is provided at Reference Daily Intake . According to the Global Fortification Data Exchange, vitamin K deficiency is so rare that no countries require that foods be fortified. The World Health Organization does not have recommendations on vitamin K fortification. Vitamin K 1
13447-409: The vine, and not corrupt. Fruit In botany , a fruit is the seed -bearing structure in flowering plants (angiosperms) that is formed from the ovary after flowering (see Fruit anatomy ). Fruits are the means by which angiosperms disseminate their seeds. Edible fruits in particular have long propagated using the movements of humans and other animals in a symbiotic relationship that
13566-418: The vitamin across the placenta, and thus low fetal plasma vitamin K. Occurrence of vitamin K deficiency bleeding in the first week of the infant's life is estimated at between 1 in 60 and 1 in 250. Human milk contains 0.85–9.2 μg/L (median 2.5 μg/L) of vitamin K 1 , while infant formula is formulated in range of 24–175 μg/L. Late onset bleeding, with onset 2 to 12 weeks after birth, can be
13685-706: The wild across the continent and were a part of the diet of many Native Americans , but they were considered by early European colonists to be unsuitable for wine. In the 19th century, Ephraim Bull of Concord, Massachusetts , cultivated seeds from wild Vitis labrusca vines to create the Concord grape , which would become an important agricultural crop in the United States. Grapes are a type of fruit that grow in clusters of 15 to 300 and can be crimson, black, dark blue, yellow, green, orange, and pink. "White" grapes are actually green in color and are evolutionarily derived from
13804-434: The world are dedicated to grapes. Approximately 71% of world grape production is used for wine, 27% as fresh fruit, and 2% as dried fruit . A portion of grape production goes to producing grape juice to be reconstituted for fruits canned "with no added sugar " and "100% natural". The area dedicated to vineyards is increasing by about 2% per year. There are no reliable statistics that break down grape production by variety. It
13923-480: The world, particularly for their role in winemaking . Other grape-derived products include various types of jam , juice , vinegar and oil. The Middle East is generally described as the homeland of grapes and the cultivation of this plant began there 6,000–8,000 years ago. Yeast , one of the earliest domesticated microorganisms , occurs naturally on the skins of grapes, leading to the discovery of alcoholic drinks such as wine. The earliest archeological evidence for
14042-485: Was not available to establish an estimated average requirement or recommended dietary allowance , terms that exist for most vitamins. In instances such as these, the academy defines adequate intakes (AIs) as amounts that appear to be sufficient to maintain good health, with the understanding that at some later date, AIs will be replaced by more exact information. The current AIs for adult women and men ages 19 and older are 90 and 120 μg/day, respectively, for pregnancy
14161-539: Was restored by the diet was taken as a measure for its vitamin K content. Three groups of physicians independently found this: Biochemical Institute, University of Copenhagen (Dam and Johannes Glavind), University of Iowa Department of Pathology (Emory Warner, Kenneth Brinkhous , and Harry Pratt Smith), and the Mayo Clinic ( Hugh Butt , Albert Snell , and Arnold Osterberg). The first published report of successful treatment with vitamin K of life-threatening hemorrhage in
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