The dorsal column–medial lemniscus pathway ( DCML ) (also known as the posterior column-medial lemniscus pathway ( PCML ) is the major sensory pathway of the central nervous system that conveys sensations of fine touch , vibration , two-point discrimination , and proprioception (body position) from the skin and joints. It transmits this information to the somatosensory cortex of the postcentral gyrus in the parietal lobe of the brain. The pathway receives information from sensory receptors throughout the body, and carries this in the gracile fasciculus and the cuneate fasciculus , tracts that make up the white matter dorsal columns (also known as the posterior funiculi ) of the spinal cord. At the level of the medulla oblongata , the fibers of the tracts decussate and are continued in the medial lemniscus , on to the thalamus and relayed from there through the internal capsule and transmitted to the somatosensory cortex. The name dorsal-column medial lemniscus comes from the two structures that carry the sensory information: the dorsal columns of the spinal cord , and the medial lemniscus in the brainstem .
27-698: [REDACTED] Look up fascicle in Wiktionary, the free dictionary. Fascicle or fasciculus may refer to: Anatomy and histology [ edit ] Muscle fascicle , a bundle of skeletal muscle fibers Nerve fascicle , a bundle of axons (nerve fibers) Superior longitudinal fasciculus Arcuate fasciculus Gracile fasciculus Cuneate fasciculus Dorsal longitudinal fasciculus Medial longitudinal fasciculus Flechsig's fasciculus Fascicular pattern of histopathologic architecture Botany [ edit ] Fascicle (botany) ,
54-424: A dendrite of a typical neuron by receiving input (although it should not be confused with a true dendrite), and one central branch that functions like a typical axon by carrying information to other neurons (again, both branches are actually part of one axon). Damage to the dorsal column-medial lemniscus pathway below the crossing point of its fibers results in loss of vibration and joint sense (proprioception) on
81-400: A bundle of axons (nerve fibers) Superior longitudinal fasciculus Arcuate fasciculus Gracile fasciculus Cuneate fasciculus Dorsal longitudinal fasciculus Medial longitudinal fasciculus Flechsig's fasciculus Fascicular pattern of histopathologic architecture Botany [ edit ] Fascicle (botany) , a cluster of flowers or leaves, such as
108-412: A cluster of flowers or leaves, such as the bundles of the thin leaves (or needles) of pines A discrete bundle of vascular tissue Other uses [ edit ] Fasciculus , a fossil comb jelly Fasciculus Chemicus , a 17th-century anthology of alchemical writings Fascicle (book) , a discrete section of a larger book or other published work issued in serial form Topics referred to by
135-403: A more lateral section called the cuneate fasciculus. These fasciculi are in an area of white matter, the posterior funiculus (a funiculus ) that lies between the posterolateral and the posterior median sulcus . They are separated by a partition of glial cells which places them on either side of the posterior intermediate sulcus. The column reaches the junction between the spinal cord and
162-434: Is at the surface of the spinal cord, and its apex directed toward the posterior gray commissure. The gracile fasciculus increases in size from inferior to superior. The cuneate fasciculus is triangular on transverse section, and lies between the gracile fasciculus and the posterior column, its base corresponding with the surface of the spinal cord. Its fibers, larger than those of the gracile fasciculus, are mostly derived from
189-403: Is different from Wikidata All article disambiguation pages All disambiguation pages fascicle [REDACTED] Look up fascicle in Wiktionary, the free dictionary. Fascicle or fasciculus may refer to: Anatomy and histology [ edit ] Muscle fascicle , a bundle of skeletal muscle fibers Nerve fascicle ,
216-422: Is medial to the more lateral cuneate tract. The axons of second-order neurons of the gracile and cuneate nuclei are known as the internal arcuate fibers and when they cross over the midline, at the sensory decussation in the medulla, they form the medial lemniscus which connects with the thalamus; the axons synapse on neurons in the ventral posterolateral nucleus which then send axons to the postcentral gyrus in
243-482: Is started. Alternatively, proprioceptive muscle spindles and other skin surface touch mechanoreceptors such as Merkel cells , bulbous corpuscles , lamellar corpuscles , and hair follicle receptors (peritrichial endings) may involve the first neuron in this pathway. The sensory neurons in this pathway are pseudounipolar , meaning that they have a single process emanating from the cell body with two distinct branches: one peripheral branch that functions somewhat like
270-471: Is well developed in the fingers of humans and allows the detection of fine textures. It also allows for the ability known as haptic perception (stereognosis), to determine what an unknown object is, using the hands without visual or audio input. Fine touch is detected by cutaneous receptors called tactile corpuscles that lie in the dermis of the skin close to the epidermis . When these structures are stimulated by slight pressure, an action potential
297-411: The medulla oblongata , where lower body axons in the gracile fasciculus connect ( synapse ) with neurons in the gracile nucleus , and upper body axons in the cuneate fasciculus synapse with neurons in the cuneate nucleus . First-order neurons secrete substance P in the dorsal horn as a chemical mediator of pain signaling. The dorsal horn of the spinal cord transmits pain and non-noxious signals from
SECTION 10
#1732852245747324-430: The parietal lobe . The gracile fasciculus carries sensory information from the lower half of the body entering the spinal cord at the lumbar level. The cuneate fasciculus carries sensory information from the upper half of the body (upper limbs, trunk, and neck) entering the spinal cord at the cervical level. The gracile fasciculus is wedge-shaped on transverse section and lies next to the posterior median septum. Its base
351-429: The same side of the body as the lesion. Damage above the crossing point result a loss of vibration and joint sense on the opposite side of the body to the lesion. The pathway is tested with Romberg's test . Damage to either of the dorsal column tracts can result in the permanent loss of sensation in the limbs. See Brown-Séquard syndrome . The cuneate fasciculus, fasciculus cuneatus, cuneate tract, tract of Burdach,
378-426: The sensory decussation . At the medulla, the medial lemniscus is orientated perpendicular to the way the fibres travelled in their tracts in the posterior column. For example, in the column, lower limb is medial, upper limb is more lateral. At the medial lemniscus, axons from the leg are more ventral, and axons from the arm are more dorsal. Fibres from the trigeminal nerve (supplying the head ) come in dorsal to
405-419: The thalamus . The third-order neurons are in the ventral posterolateral nucleus in the thalamus and fibres from these ascend to the postcentral gyrus. Sensory information from the upper half of the body is received at the cervical level of the spinal cord and carried in the cuneate tract, and information from the lower body is received at the lumbar level and carried in the gracile tract. The gracile tract
432-464: The ventral posteromedial nucleus for sensation from the head). Axons from the third-order neurons in the ventral posterior nucleus in the thalamus, ascend the posterior limb of the internal capsule . Those originating from the head and the leg swap their relative positions. The axons synapse in the primary somatosensory cortex , with lower body sensation most medial (e.g., the paracentral lobule) and upper body more lateral. Discriminative sensation
459-414: The arm fibres, and travel up the lemniscus too. The medial lemniscus rotates 90 degrees at the pons . The secondary axons from neurons giving sensation to the head, stay at around the same place, while the leg axons move outwards. The axons travel up the rest of the brainstem, and synapse at the thalamus (at the ventral posterolateral nucleus for sensation from the neck, trunk, and extremities, and at
486-462: The bundles of the thin leaves (or needles) of pines A discrete bundle of vascular tissue Other uses [ edit ] Fasciculus , a fossil comb jelly Fasciculus Chemicus , a 17th-century anthology of alchemical writings Fascicle (book) , a discrete section of a larger book or other published work issued in serial form Topics referred to by the same term [REDACTED] This disambiguation page lists articles associated with
513-404: The neuron through the posterior root , into the posterior horn , and up the posterior column of the spinal cord . Axons from the lower body enter the posterior column below the level of T6 and travel in the midline section of the column called the gracile fasciculus. Axons from the upper body enter at or above T6 and travel up the posterior column on the outside of the gracile fasciculus in
540-456: The parietal lobe. All of the axons in the DCML pathway are rapidly conducting, large, myelinated fibers. The DCML pathway is made up of the axons of first, second, and third-order sensory neurons , beginning in the dorsal root ganglia . The axons from the first-order neurons form the ascending tracts of the gracile fasciculus , and the cuneate fasciculus (the dorsal columns ) which synapse on
567-451: The pathway: first-order neurons , second-order neurons , and third-order neurons . The first-order neurons are sensory neurons located in the dorsal root ganglia , that send their afferent fibers through the two dorsal columns. The first-order axons make contact with second-order neurons of the dorsal column nuclei (the gracile nucleus and the cuneate nucleus ) in the lower medulla . The second-order neurons send their axons to
SECTION 20
#1732852245747594-400: The periphery to the spinal cord itself. Adenosine is another local molecule that modulates dorsal horn pain transmission The neurons in these two nuclei (the dorsal column nuclei ) are second-order neurons. Their axons cross over to the other side of the medulla and are now named as the internal arcuate fibers , that form the medial lemniscus on each side. This crossing over is known as
621-408: The physical point of reception to the actual point of interpretation in the brain. When an action potential is generated by a mechanoreceptor in the tissue , the action potential will travel along the peripheral axon of the first-order neuron. The first-order neuron is pseudounipolar in shape with its body in the dorsal root ganglion . The action signal will continue along the central axon of
648-552: The same source, viz., the posterior nerve roots. Some ascend for only a short distance in the tract, and, entering the gray matter, come into close relationship with the cells of the dorsal nucleus, while others can be traced as far as the medulla oblongata, where they end in the gracile nucleus and cuneate nucleus. The two ascending tracts meet at the level of the sixth thoracic vertebra (T6). Ascending tracts typically have three levels of neurons, namely first-order , second-order , and third-order neurons , that relay information from
675-413: The same term [REDACTED] This disambiguation page lists articles associated with the title Fascicle . If an internal link led you here, you may wish to change the link to point directly to the intended article. Retrieved from " https://en.wikipedia.org/w/index.php?title=Fascicle&oldid=1129975577 " Category : Disambiguation pages Hidden categories: Short description
702-418: The second-order neurons in the gracile nucleus and the cuneate nucleus known together as the dorsal column nuclei ; axons from these neurons ascend as the internal arcuate fibers ; the fibers cross over at the sensory decussation and form the medial lemniscus which connects with the thalamus ; the axons synapse on neurons in the ventral nuclear group which then send axons to the postcentral gyrus in
729-547: The title Fascicle . If an internal link led you here, you may wish to change the link to point directly to the intended article. Retrieved from " https://en.wikipedia.org/w/index.php?title=Fascicle&oldid=1129975577 " Category : Disambiguation pages Hidden categories: Short description is different from Wikidata All article disambiguation pages All disambiguation pages Dorsal column%E2%80%93medial lemniscus pathway#Structure There are three groupings of neurons that are involved in
#746253