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127-456: A drug is any chemical substance other than a nutrient or an essential dietary ingredient, which, when administered to a living organism, produces a biological effect. Consumption of drugs can be via inhalation , injection , smoking , ingestion , absorption via a patch on the skin, suppository , or dissolution under the tongue . In pharmacology , a drug is a chemical substance, typically of known structure, which, when administered to

254-452: A chemical reaction form a chemical compound . All compounds are substances, but not all substances are compounds. A chemical compound can be either atoms bonded together in molecules or crystals in which atoms, molecules or ions form a crystalline lattice . Compounds based primarily on carbon and hydrogen atoms are called organic compounds , and all others are called inorganic compounds . Compounds containing bonds between carbon and

381-660: A database and is popularly known as the Chemical substances index. Other computer-friendly systems that have been developed for substance information are: SMILES and the International Chemical Identifier or InChI. Often a pure substance needs to be isolated from a mixture , for example from a natural source (where a sample often contains numerous chemical substances) or after a chemical reaction (which often gives mixtures of chemical substances). Stoichiometry ( / ˌ s t ɔɪ k i ˈ ɒ m ɪ t r i / )

508-574: A mixture , referencing them in the chemical substances index allows CAS to offer specific guidance on standard naming of alloy compositions. Non-stoichiometric compounds are another special case from inorganic chemistry , which violate the requirement for constant composition. For these substances, it may be difficult to draw the line between a mixture and a compound, as in the case of palladium hydride . Broader definitions of chemicals or chemical substances can be found, for example: "the term 'chemical substance' means any organic or inorganic substance of

635-467: A pharmacist without needing a doctor's prescription, and prescription only medicines , which must be prescribed by a licensed medical professional , usually a physician . In the United Kingdom, behind-the-counter medicines are called pharmacy medicines which can only be sold in registered pharmacies, by or under the supervision of a pharmacist. These medications are designated by the letter P on

762-469: A stimulant , a sedative , a euphoriant and an anesthetic . The roots of the kava plant are used to produce a drink consumed throughout the cultures of the Pacific Ocean. Some shamans from different cultures use entheogens, defined as "generating the divine within," to achieve religious ecstasy . Amazonian shamans use ayahuasca (yagé), a hallucinogenic brew, for this purpose. Mazatec shamans have

889-417: A study drug , is methylphenidate branded commonly as Ritalin and used for the treatment of attention deficit hyperactivity disorder (ADHD) and narcolepsy . At high doses methylphenidate can become highly addictive . Serious addiction can lead to psychosis , anxiety and heart problems, and the use of this drug is related to a rise in suicides, and overdoses. Evidence for use outside of student settings

1016-618: A "ligand". However, the center does not need to be a metal, as exemplified by boron trifluoride etherate BF 3 OEt 2 , where the highly Lewis acidic , but non-metallic boron center takes the role of the "metal". If the ligand bonds to the metal center with multiple atoms, the complex is called a chelate . In organic chemistry, there can be more than one chemical compound with the same composition and molecular weight. Generally, these are called isomers . Isomers usually have substantially different chemical properties, and often may be isolated without spontaneously interconverting. A common example

1143-562: A brief period in the 1330s and 1340s, Castile tended to be nonetheless "essentially unstable" from a political standpoint until the late 15th century. Merchants from Genoa and Pisa were conducting an intense trading activity in Catalonia already by the 12th century, and later in Portugal. Since the 13th century, the Crown of Aragon expanded overseas; led by Catalans , it attained an overseas empire in

1270-416: A chemical reaction takes place and a new substance is formed, the compound iron(II) sulfide , with chemical formula FeS. The resulting compound has all the properties of a chemical substance and is not a mixture. Iron(II) sulfide has its own distinct properties such as melting point and solubility , and the two elements cannot be separated using normal mechanical processes; a magnet will be unable to recover

1397-411: A living organism, produces a biological effect. A pharmaceutical drug , also called a medication or medicine, is a chemical substance used to treat , cure, prevent , or diagnose a disease or to promote well-being . Traditionally drugs were obtained through extraction from medicinal plants , but more recently also by organic synthesis . Pharmaceutical drugs may be used for a limited duration, or on

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1524-499: A long and continuous tradition of religious use of Salvia divinorum , a psychoactive plant. Its use is to facilitate visionary states of consciousness during spiritual healing sessions. Silene undulata is regarded by the Xhosa people as a sacred plant and used as an entheogen. Its roots are traditionally used to induce vivid (and according to the Xhosa, prophetic) lucid dreams during

1651-436: A metal are called organometallic compounds . Compounds in which components share electrons are known as covalent compounds. Compounds consisting of oppositely charged ions are known as ionic compounds, or salts . Coordination complexes are compounds where a dative bond keeps the substance together without a covalent or ionic bond. Coordination complexes are distinct substances with distinct properties different from

1778-462: A particular molecular identity, including – (i) any combination of such substances occurring in whole or in part as a result of a chemical reaction or occurring in nature". In the field of geology , inorganic solid substances of uniform composition are known as minerals . When two or more minerals are combined to form mixtures (or aggregates ), they are defined as rocks . Many minerals, however, mutually dissolve into solid solutions , such that

1905-629: A particular mutation in the EGFR gene. Some drugs are specifically approved for certain genotypes. Vemurafenib is such a case which is used for melanoma patients who carry a mutation in BRAF gene. The number of people who benefit from a drug determines if drug trials are worth carrying out, given that phase III trials may cost between $ 100 million and $ 700 million per drug. This is the motivation behind personalized medicine , that is, to develop drugs that are adapted to individual patients. A medication or medicine

2032-581: A permanent trading port in the Gadir colony c.  800 BCE in response to the increasing demand of silver from the Assyrian Empire . The seafaring Phoenicians, Greeks and Carthaginians successively settled along the Mediterranean coast and founded trading colonies there over several centuries. In the 8th century BCE, the first Greek colonies , such as Emporion (modern Empúries ), were founded along

2159-553: A population of 100,000 by the 10th century, Toledo 30,000 by the 11th century and Seville 80,000 by the 12th century. During the Middle Ages, the North of the peninsula housed many small Christian polities including the Kingdom of Castile , the Kingdom of Aragon , the Kingdom of Navarre , the Kingdom of León or the Kingdom of Portugal , as well as a number of counties that spawned from

2286-701: A population of roughly 53 million, it is the second-largest European peninsula by area, after the Scandinavian Peninsula . The Iberian Peninsula has always been associated with the River Ebro (Ibēros in ancient Greek and Ibērus or Hibērus in Latin ). The association was so well known it was hardly necessary to state; for example, Ibēria was the country "this side of the Ibērus" in Strabo. Pliny goes so far as to assert that

2413-446: A regular basis for chronic disorders . Pharmaceutical drugs are often classified into drug classes —groups of related drugs that have similar chemical structures , the same mechanism of action (binding to the same biological target ), a related mode of action , and that are used to treat the same disease. The Anatomical Therapeutic Chemical Classification System (ATC), the most widely used drug classification system, assigns drugs

2540-637: A role in the conflict by providing key naval support to France that helped lead to that nation's eventual victory. After the accession of Henry III to the throne of Castile, the populace, exasperated by the preponderance of Jewish influence, perpetrated a massacre of Jews at Toledo. In 1391, mobs went from town to town throughout Castile and Aragon, killing an estimated 50,000 Jews, or even as many as 100,000, according to Jane Gerber . Women and children were sold as slaves to Muslims, and many synagogues were converted into churches. According to Hasdai Crescas , about 70 Jewish communities were destroyed. During

2667-437: A separate chemical substance. However, the polymer may be defined by a known precursor or reaction(s) and the molar mass distribution . For example, polyethylene is a mixture of very long chains of -CH 2 - repeating units, and is generally sold in several molar mass distributions, LDPE , MDPE , HDPE and UHMWPE . The concept of a "chemical substance" became firmly established in the late eighteenth century after work by

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2794-400: A simple mixture. Typically these have a metal, such as a copper ion, in the center and a nonmetals atom, such as the nitrogen in an ammonia molecule or oxygen in water in a water molecule, forms a dative bond to the metal center, e.g. tetraamminecopper(II) sulfate [Cu(NH 3 ) 4 ]SO 4 ·H 2 O. The metal is known as a "metal center" and the substance that coordinates to the center is called

2921-479: A single chemical substance ( allotropes ). For instance, oxygen exists as both diatomic oxygen (O 2 ) and ozone (O 3 ). The majority of elements are classified as metals . These are elements with a characteristic lustre such as iron , copper , and gold . Metals typically conduct electricity and heat well, and they are malleable and ductile . Around 14 to 21 elements, such as carbon , nitrogen , and oxygen , are classified as non-metals . Non-metals lack

3048-430: A single manufacturing process. For example, charcoal is an extremely complex, partially polymeric mixture that can be defined by its manufacturing process. Therefore, although the exact chemical identity is unknown, identification can be made with a sufficient accuracy. The CAS index also includes mixtures. Polymers almost always appear as mixtures of molecules of multiple molar masses, each of which could be considered

3175-723: A single rock is a uniform substance despite being a mixture in stoichiometric terms. Feldspars are a common example: anorthoclase is an alkali aluminum silicate, where the alkali metal is interchangeably either sodium or potassium. In law, "chemical substances" may include both pure substances and mixtures with a defined composition or manufacturing process. For example, the EU regulation REACH defines "monoconstituent substances", "multiconstituent substances" and "substances of unknown or variable composition". The latter two consist of multiple chemical substances; however, their identity can be established either by direct chemical analysis or reference to

3302-560: A sudden economic cessation. Many settlements in northern Castile and Catalonia were left forsaken. The plague marked the start of the hostility and downright violence towards religious minorities (particularly the Jews) as an additional consequence in the Iberian realms. The 14th century was a period of great upheaval in the Iberian realms. After the death of Peter the Cruel of Castile (reigned 1350–69),

3429-495: A technical specification instead of particular chemical substances. For example, gasoline is not a single chemical compound or even a particular mixture: different gasolines can have very different chemical compositions, as "gasoline" is primarily defined through source, properties and octane rating . Every chemical substance has one or more systematic names , usually named according to the IUPAC rules for naming . An alternative system

3556-674: A unique ATC code , which is an alphanumeric code that assigns it to specific drug classes within the ATC system. Another major classification system is the Biopharmaceutics Classification System . This groups drugs according to their solubility and permeability or absorption properties. Some religions, particularly ethnic religions , are based completely on the use of certain drugs, known as entheogens , which are mostly hallucinogens ,— psychedelics , dissociatives , or deliriants . Some entheogens include kava which can act as

3683-726: A unique ATC code, which is an alphanumeric code that assigns it to specific drug classes within the ATC system. Another major classification system is the Biopharmaceutics Classification System . This classifies drugs according to their solubility and permeability or absorption properties. Psychoactive drugs are substances that affect the function of the central nervous system , altering perception , mood or consciousness . These drugs are divided into different groups like: stimulants , depressants , antidepressants , anxiolytics , antipsychotics , and hallucinogens . These psychoactive drugs have been proven useful in treating wide range of medical conditions including mental disorders around

3810-442: A yellow-grey mixture. No chemical process occurs, and the material can be identified as a mixture by the fact that the sulfur and the iron can be separated by a mechanical process, such as using a magnet to attract the iron away from the sulfur. In contrast, if iron and sulfur are heated together in a certain ratio (1 atom of iron for each atom of sulfur, or by weight, 56 grams (1 mol ) of iron to 32 grams (1 mol) of sulfur),

3937-436: Is glucose vs. fructose . The former is an aldehyde , the latter is a ketone . Their interconversion requires either enzymatic or acid-base catalysis . However, tautomers are an exception: the isomerization occurs spontaneously in ordinary conditions, such that a pure substance cannot be isolated into its tautomers, even if these can be identified spectroscopically or even isolated in special conditions. A common example

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4064-704: Is glucose , which has open-chain and ring forms. One cannot manufacture pure open-chain glucose because glucose spontaneously cyclizes to the hemiacetal form. All matter consists of various elements and chemical compounds, but these are often intimately mixed together. Mixtures contain more than one chemical substance, and they do not have a fixed composition. Butter , soil and wood are common examples of mixtures. Sometimes, mixtures can be separated into their component substances by mechanical processes, such as chromatography , distillation , or evaporation . Grey iron metal and yellow sulfur are both chemical elements, and they can be mixed together in any ratio to form

4191-487: Is a drug taken to cure or ameliorate any symptoms of an illness or medical condition. The use may also be as preventive medicine that has future benefits but does not treat any existing or pre-existing diseases or symptoms. Dispensing of medication is often regulated by governments into three categories— over-the-counter medications, which are available in pharmacies and supermarkets without special restrictions; behind-the-counter medicines, which are dispensed by

4318-653: Is a peninsula in south-western Europe . Mostly separated from the rest of the European landmass by the Pyrenees , it includes the territories of Peninsular Spain and Continental Portugal , comprising most of the region, as well as the tiny adjuncts of Andorra , Gibraltar , and, pursuant to the traditional definition of the Pyrenees as the peninsula's northeastern boundary, a small part of France . With an area of approximately 583,254 square kilometres (225,196 sq mi), and

4445-592: Is a chemical substance made up of a particular kind of atom and hence cannot be broken down or transformed by a chemical reaction into a different element, though it can be transmuted into another element through a nuclear reaction . This is because all of the atoms in a sample of an element have the same number of protons , though they may be different isotopes , with differing numbers of neutrons . As of 2019, there are 118 known elements, about 80 of which are stable – that is, they do not change by radioactive decay into other elements. Some elements can occur as more than

4572-402: Is an example of complete combustion . Stoichiometry measures these quantitative relationships, and is used to determine the amount of products and reactants that are produced or needed in a given reaction. Describing the quantitative relationships among substances as they participate in chemical reactions is known as reaction stoichiometry . In the example above, reaction stoichiometry measures

4699-417: Is an example of a chemical substance, with a constant composition of two hydrogen atoms bonded to a single oxygen atom (i.e. H 2 O). The atomic ratio of hydrogen to oxygen is always 2:1 in every molecule of water. Pure water will tend to boil near 100 °C (212 °F), an example of one of the characteristic properties that define it. Other notable chemical substances include diamond (a form of

4826-577: Is limited but suggests that it is commonplace. Intravenous use of methylphenidate can lead to emphysematous damage to the lungs, known as Ritalin lung . Other drugs known as designer drugs are produced. An early example of what today would be labelled a 'designer drug' was LSD , which was synthesised from ergot . Other examples include analogs of performance-enhancing drugs such as designer steroids taken to improve physical capabilities; these are sometimes used (legally or not) for this purpose, often by professional athletes. Other designer drugs mimic

4953-609: Is testimony to a considerable input from various waves of (predominantly male) Western Steppe Herders from the Pontic–Caspian steppe during the Bronze Age. Iberia experienced a significant genetic turnover, with 100% of the paternal ancestry and 40% of the overall ancestry being replaced by peoples with steppe-related ancestry. In the Chalcolithic ( c.  3000 BCE), a series of complex cultures developed that would give rise to

5080-411: Is the relationships among the weights of reactants and products before, during, and following chemical reactions . Stoichiometry is founded on the law of conservation of mass where the total mass of the reactants equals the total mass of the products, leading to the insight that the relations among quantities of reactants and products typically form a ratio of positive integers. This means that if

5207-506: Is the use of a drug (legal, controlled, or illegal) with the primary intention of altering the state of consciousness through alteration of the central nervous system in order to create positive emotions and feelings. The hallucinogen LSD is a psychoactive drug commonly used as a recreational drug. Ketamine is a drug used for anesthesia , and is also used as a recreational drug, both in powder and liquid form, for its hallucinogenic and dissociative effects . Some national laws prohibit

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5334-486: Is used by the Chemical Abstracts Service (CAS). Many compounds are also known by their more common, simpler names, many of which predate the systematic name. For example, the long-known sugar glucose is now systematically named 6-(hydroxymethyl)oxane-2,3,4,5-tetrol. Natural products and pharmaceuticals are also given simpler names, for example the mild pain-killer Naproxen is the more common name for

5461-653: The Ṣaqāliba (literally meaning "slavs", although they were slaves of generic European origin) as well as Sudanese slaves. The Umayyad rulers faced a major Berber Revolt in the early 740s; the uprising originally broke out in North Africa (Tangier) and later spread across the peninsula. Following the Abbasid takeover from the Umayyads and the shift of the economic centre of the Islamic Caliphate from Damascus to Baghdad,

5588-679: The Aurignacian , Gravettian , Solutrean and Magdalenian cultures, some of them characterized by the complex forms of the art of the Upper Paleolithic . During the Neolithic expansion , various megalithic cultures developed in the Iberian Peninsula. An open seas navigation culture from the east Mediterranean, called the Cardium culture , also extended its influence to the eastern coasts of

5715-652: The Ebro ) as far north as the Rhône , but in his day they set the Pyrenees as the limit. Polybius respects that limit, but identifies Iberia as the Mediterranean side as far south as Gibraltar , with the Atlantic side having no name. Elsewhere he says that Saguntum is "on the seaward foot of the range of hills connecting Iberia and Celtiberia." According to Charles Ebel, the ancient sources in both Latin and Greek use Hispania and Hiberia (Greek: Iberia ) as synonyms. The confusion of

5842-601: The House of Trastámara succeeded to the throne in the person of Peter's half brother, Henry II (reigned 1369–79). In the kingdom of Aragón, following the death without heirs of John I (reigned 1387–96) and Martin I (reigned 1396–1410), a prince of the House of Trastámara, Ferdinand I (reigned 1412–16), succeeded to the Aragonese throne. The Hundred Years' War also spilled over into the Iberian peninsula, with Castile particularly taking

5969-934: The Narcotics Control Bureau (NCB), an Indian federal law enforcement and intelligence agency under the Ministry of Home Affairs , is tasked with combating drug trafficking and assisting international use of illegal substances under the provisions of Narcotic Drugs and Psychotropic Substances Act . Chemical substance Chemical substances can exist in several different physical states or phases (e.g. solids , liquids , gases , or plasma ) without changing their chemical composition. Substances transition between these phases of matter in response to changes in temperature or pressure . Some chemical substances can be combined or converted into new substances by means of chemical reactions . Chemicals that do not possess this ability are said to be inert . Pure water

6096-755: The Phoenician alphabet and originated in Southwestern Iberia by the 7th century BCE has been tentatively proposed. In the sixth century BCE, the Carthaginians arrived in the peninsula while struggling with the Greeks for control of the Western Mediterranean. Their most important colony was Carthago Nova (modern-day Cartagena, Spain ). In 218 BCE, during the Second Punic War against the Carthaginians,

6223-584: The Phoenicians , by voyaging westward on the Mediterranean . Hecataeus of Miletus was the first known to use the term Iberia , which he wrote about c.  500 BCE . Herodotus of Halicarnassus says of the Phocaeans that "it was they who made the Greeks acquainted with [...] Iberia." According to Strabo , prior historians used Iberia to mean the country "this side of the Ἶβηρος ( Ibēros ,

6350-476: The Single Convention on Narcotic Drugs exist for the purpose of their prohibition . In English, the noun "drug" is thought to originate from Old French " drogue ", possibly deriving from " droge ( vate )" from Middle Dutch meaning "dry (barrels)", referring to medicinal plants preserved as dry matter in barrels. In the 1990s however, Spanish lexicographer Federico Corriente Córdoba documented

6477-768: The Strait of Gibraltar and founded upon a vassalage relationship with the Crown of Castile, also insinuated itself into the European mercantile network, with its ports fostering intense trading relations with the Genoese as well, but also with the Catalans, and to a lesser extent, with the Venetians, the Florentines, and the Portuguese. Between 1275 and 1340, Granada became involved in the "crisis of

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6604-591: The 15th century, Portugal, which had ended its southwards territorial expansion across the Iberian Peninsula in 1249 with the conquest of the Algarve, initiated an overseas expansion in parallel to the rise of the House of Aviz , conquering Ceuta (1415) arriving at Porto Santo (1418), Madeira and the Azores , as well as establishing additional outposts along the North-African Atlantic coast. In addition, already in

6731-677: The Carolingian Marca Hispanica . Christian and Muslim polities fought and allied among themselves in variable alliances. The Christian kingdoms progressively expanded south taking over Muslim territory in what is historiographically known as the " Reconquista " (the latter concept has been however noted as product of the claim to a pre-existing Spanish Catholic nation and it would not necessarily convey adequately "the complexity of centuries of warring and other more peaceable interactions between Muslim and Christian kingdoms in medieval Iberia between 711 and 1492"). The Caliphate of Córdoba

6858-549: The Chalcolithic sites of Los Millares, the Argaric culture flourished in southeastern Iberia in from 2200 BC to 1550 BC, when depopulation of the area ensued along with disappearing of copper–bronze–arsenic metallurgy. The most accepted model for El Argar has been that of an early state society, most particularly in terms of class division, exploitation, and coercion, with agricultural production, maybe also human labour, controlled by

6985-638: The Christian Iberian kingdoms by the beginning of the 13th century, in relation to the more or less conflictual border with Muslim lands. By the beginning of the 13th century, a power reorientation took place in the Iberian Peninsula (parallel to the Christian expansion in Southern Iberia and the increasing commercial impetus of Christian powers across the Mediterranean) and to a large extent, trade-wise,

7112-790: The Early Modern Period, between the completion of the Granada War in 1492 and the death of Ferdinand of Aragon in 1516, the Hispanic Monarchy would make strides in the imperial expansion along the Mediterranean coast of the Maghreb. During the Late Middle Ages, the Jews acquired considerable power and influence in Castile and Aragon. Throughout the late Middle Ages, the Crown of Aragon took part in

7239-752: The Greeks had called "the whole of the peninsula" Hiberia because of the Hiberus River. The river appears in the Ebro Treaty of 226 BCE between Rome and Carthage, setting the limit of Carthaginian interest at the Ebro. The fullest description of the treaty, stated in Appian , uses Ibērus. With reference to this border, Polybius states that the "native name" is Ibēr , apparently the original word, stripped of its Greek or Latin -os or -us termination. The early range of these natives, which geographers and historians place from

7366-509: The Hispano-Roman population took place, ( muwalladum or Muladí ). After a long process, spurred on in the 9th and 10th centuries, the majority of the population in Al-Andalus eventually converted to Islam. The Muslims were referred to by the generic name Moors . The Muslim population was divided per ethnicity (Arabs, Berbers, Muladí), and the supremacy of Arabs over the rest of group

7493-529: The Iberian Peninsula reorientated towards the North away from the Muslim World. During the Middle Ages, the monarchs of Castile and León, from Alfonso V and Alfonso VI (crowned Hispaniae Imperator ) to Alfonso X and Alfonso XI tended to embrace an imperial ideal based on a dual Christian and Jewish ideology. Despite the hegemonic ambitions of its rulers and the consolidation of the union of Castile and León after 1230, it should be pointed that, except for

7620-608: The Islamic army landed at Gibraltar and, in an eight-year campaign, occupied all except the northern kingdoms of the Iberian Peninsula in the Umayyad conquest of Hispania . Al-Andalus ( Arabic : الإندلس , tr. al-ʾAndalūs , possibly "Land of the Vandals"), is the Arabic name given to Muslim Iberia. The Muslim conquerors were Arabs and Berbers ; following the conquest, conversion and arabization of

7747-470: The Mediterranean coast on the east, leaving the south coast to the Phoenicians. Together with the presence of Phoenician and Greek epigraphy, several paleohispanic scripts developed in the Iberian Peninsula along the 1st millennium BCE. The development of a primordial paleohispanic script antecessor to the rest of paleohispanic scripts (originally supposed to be a non-redundant semi-syllabary ) derived from

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7874-620: The Mediterranean during Classical Antiquity having no match until the Industrial Revolution . In addition to mineral extraction (of which the region was the leading supplier in the early Roman world, with production of the likes of gold, silver, copper, lead, and cinnabar ), Hispania also produced manufactured goods ( sigillata pottery, colourless glass , linen garments) fish and fish sauce ( garum ), dry crops (such as wheat and, more importantly, esparto ), olive oil , and wine . The process of Romanization spurred on throughout

8001-431: The Neanderthal Châtelperronian cultural period began. Emanating from Southern France , this culture extended into the north of the peninsula. It continued to exist until around 30,000 BP, when Neanderthal man faced extinction. About 40,000 years ago, anatomically modern humans entered the Iberian Peninsula from across the Pyrenees. On the Iberian Peninsula, modern humans developed a series of different cultures, such as

8128-437: The Strait", and was caught in a complex geopolitical struggle ("a kaleidoscope of alliances") with multiple powers vying for dominance of the Western Mediterranean, complicated by the unstable relations of Muslim Granada with the Marinid Sultanate . The conflict reached a climax in the 1340 Battle of Río Salado , when, this time in alliance with Granada, the Marinid Sultan (and Caliph pretender) Abu al-Hasan Ali ibn Othman made

8255-431: The Suebi kingdom and its capital city, Bracara (modern day Braga ), in 584–585. They would also occupy the province of the Byzantine Empire (552–624) of Spania in the south of the peninsula . However, Balearic Islands remained in Byzantine hands until Umayyad conquest, which began in 703 CE and was completed in 902 CE. In 711, a Muslim army conquered the Visigothic Kingdom in Hispania . Under Tariq ibn Ziyad ,

8382-573: The United States . Where it is legislated against, the degree of prohibition also varies. The Food and Drug Administration (FDA) in the United States is a federal agency responsible for protecting and promoting public health through the regulation and supervision of food safety , tobacco products , dietary supplements , prescription and over-the-counter medications , vaccines , biopharmaceuticals , blood transfusions , medical devices , electromagnetic radiation emitting devices, cosmetics , animal foods and veterinary drugs . In India,

8509-491: The Western Mediterranean, with a presence in Mediterranean islands such as the Balearics , Sicily and Sardinia , and even conquering Naples in the mid-15th century. Genoese merchants invested heavily in the Iberian commercial enterprise with Lisbon becoming, according to Virgínia Rau , the "great centre of Genoese trade" in the early 14th century. The Portuguese would later detach their trade to some extent from Genoese influence. The Nasrid Kingdom of Granada , neighbouring

8636-420: The aftermath of the conquest increased mining extractive processes in the southwest of the peninsula (which required a massive number of forced laborers, initially from Hispania and latter also from the Gallic borderlands and other locations of the Mediterranean), bringing in a far-reaching environmental outcome vis-à-vis long-term global pollution records, with levels of atmospheric pollution from mining across

8763-532: The amounts of the separate reactants are known, then the amount of the product can be calculated. Conversely, if one reactant has a known quantity and the quantity of the products can be empirically determined, then the amount of the other reactants can also be calculated. This is illustrated in the image here, where the balanced equation is: Here, one molecule of methane reacts with two molecules of oxygen gas to yield one molecule of carbon dioxide and two molecules of water . This particular chemical equation

8890-453: The application, but higher tolerance of impurities is usually expected in the production of bulk chemicals. Thus, the user of the chemical in the US might choose between the bulk or "technical grade" with higher amounts of impurities or a much purer "pharmaceutical grade" (labeled "USP", United States Pharmacopeia ). "Chemicals" in the commercial and legal sense may also include mixtures of highly variable composition, as they are products made to

9017-408: The chemical combination of the known chemical elements. As of Feb 2021, about "177 million organic and inorganic substances" (including 68 million defined-sequence biopolymers) are in the scientific literature and registered in public databases. The names of many of these compounds are often nontrivial and hence not very easy to remember or cite accurately. Also, it is difficult to keep track of them in

9144-451: The chemical compound (S)-6-methoxy-α-methyl-2-naphthaleneacetic acid. Chemists frequently refer to chemical compounds using chemical formulae or molecular structure of the compound. There has been a phenomenal growth in the number of chemical compounds being synthesized (or isolated), and then reported in the scientific literature by professional chemists around the world. An enormous number of chemical compounds are possible through

9271-460: The chemical industry, manufactured "chemicals" are chemical substances, which can be classified by production volume into bulk chemicals, fine chemicals and chemicals found in research only: The cause of the difference in production volume is the complexity of the molecular structure of the chemical. Bulk chemicals are usually much less complex. While fine chemicals may be more complex, many of them are simple enough to be sold as "building blocks" in

9398-402: The chemical substances of which fruits and vegetables, for example, are naturally composed even when growing wild are not called "chemicals" in general usage. In countries that require a list of ingredients in products, the "chemicals" listed are industrially produced "chemical substances". The word "chemical" is also often used to refer to addictive, narcotic, or mind-altering drugs. Within

9525-419: The chemist Joseph Proust on the composition of some pure chemical compounds such as basic copper carbonate . He deduced that, "All samples of a compound have the same composition; that is, all samples have the same proportions, by mass, of the elements present in the compound." This is now known as the law of constant composition . Later with the advancement of methods for chemical synthesis particularly in

9652-576: The culture of Los Millares was followed by that of El Argar . During the Early Bronze Age, southeastern Iberia saw the emergence of important settlements, a development that has compelled some archeologists to propose that these settlements indicate the advent of state-level social structures. From this centre, bronze metalworking technology spread to other cultures like the Bronze of Levante , South-Western Iberian Bronze and Las Cogotas . Preceded by

9779-565: The delineation of Iberia from Gaul ( Keltikē ) by the Pyrenees and included the entire land mass southwest (he says "west") from there. With the fall of the Western Roman Empire and the consolidation of Romance languages , the word "Iberia" continued the Roman word Hiberia and the Greek word Ἰβηρία . The ancient Greeks reached the Iberian Peninsula, of which they had heard from

9906-732: The early fifth century, Germanic peoples occupied the peninsula, namely the Suebi , the Vandals ( Silingi and Hasdingi ) and their allies, the Alans . Only the kingdom of the Suebi ( Quadi and Marcomanni ) would endure after the arrival of another wave of Germanic invaders, the Visigoths , who occupied all of the Iberian Peninsula and expelled or partially integrated the Vandals and the Alans. The Visigoths eventually occupied

10033-444: The effects of psychoactive drugs. Since the late 1990s there has been the identification of many of these synthesised drugs. In Japan and the United Kingdom this has spurred the addition of many designer drugs into a newer class of controlled substances known as a temporary class drug . Synthetic cannabinoids have been produced for a longer period of time and are used in the designer drug synthetic cannabis . Recreational drug use

10160-531: The element carbon ), table salt (NaCl; an ionic compound ), and refined sugar (C 12 H 22 O 11 ; an organic compound ). In addition to the generic definition offered above, there are several niche fields where the term "chemical substance" may take alternate usages that are widely accepted, some of which are outlined in the sections below. Chemical Abstracts Service (CAS) lists several alloys of uncertain composition within their chemical substance index. While an alloy could be more closely defined as

10287-759: The feebleness of the taifa principalities, Ferdinand I of León seized Lamego and Viseu (1057–1058) and Coimbra (1064) away from the Taifa of Badajoz (at times at war with the Taifa of Seville ); Meanwhile, in the same year Coimbra was conquered, in the Northeastern part of the Iberian Peninsula, the Kingdom of Aragon took Barbastro from the Hudid Taifa of Lérida as part of an international expedition sanctioned by Pope Alexander II. Most critically, Alfonso VI of León-Castile conquered Toledo and its wider taifa in 1085, in what it

10414-612: The first Roman troops occupied the Iberian Peninsula, known to them as Hispania . After 197, the territories of the peninsula most accustomed to external contact and with the most urban tradition (the Mediterranean Coast and the Guadalquivir Valley) were divided by Romans into Hispania Ulterior and Hispania Citerior . Local rebellions were quelled, with a 195 Roman campaign under Cato the Elder ravaging hotspots of resistance in

10541-551: The first century BC. The peninsula was also the battleground of civil wars between rulers of the Roman republic; such as the Sertorian War , and the conflict between Caesar and Pompey later in the century. During their 600-year occupation of the Iberian Peninsula, the Romans introduced the Latin language that influenced many of the languages that exist today in the Iberian peninsula. In

10668-444: The former Carthaginian territories, the Romans began to use the names Hispania Citerior and Hispania Ulterior for 'near' and 'far' Hispania. At the time Hispania was made up of three Roman provinces : Hispania Baetica , Hispania Tarraconensis , and Hispania Lusitania . Strabo says that the Romans use Hispania and Iberia synonymously, distinguishing between the near northern and the far southern provinces. (The name Iberia

10795-398: The idea of stereoisomerism – that atoms have rigid three-dimensional structure and can thus form isomers that differ only in their three-dimensional arrangement – was another crucial step in understanding the concept of distinct chemical substances. For example, tartaric acid has three distinct isomers, a pair of diastereomers with one diastereomer forming two enantiomers . An element

10922-617: The inhabitants of the territory with the environment. By the Iron Age , starting in the 8th century BCE, the Iberian Peninsula consisted of complex agrarian and urban civilizations, either Pre-Celtic or Celtic (such as the Celtiberians , Gallaeci , Astures , Celtici , Lusitanians and others), the cultures of the Iberians in the eastern and southern zones and the cultures of the Aquitanian in

11049-435: The initiation process of shamans , classifying it a naturally occurring oneirogen similar to the more well-known dream herb Calea ternifolia . Peyote , a small spineless cactus , has been a major source of psychedelic mescaline and has probably been used by Native Americans for at least five thousand years. Most mescaline is now obtained from a few species of columnar cacti in particular from San Pedro and not from

11176-414: The iron, since there is no metallic iron present in the compound. While the term chemical substance is a precise technical term that is synonymous with chemical for chemists, the word chemical is used in general usage to refer to both (pure) chemical substances and mixtures (often called compounds ), and especially when produced or purified in a laboratory or an industrial process. In other words,

11303-409: The label. The range of medicines available without a prescription varies from country to country. Medications are typically produced by pharmaceutical companies and are often patented to give the developer exclusive rights to produce them. Those that are not patented (or with expired patents) are called generic drugs since they can be produced by other companies without restrictions or licenses from

11430-425: The large number of chemical substances reported in chemistry literature need to be indexed. Isomerism caused much consternation to early researchers, since isomers have exactly the same composition, but differ in configuration (arrangement) of the atoms. For example, there was much speculation about the chemical identity of benzene , until the correct structure was described by Friedrich August Kekulé . Likewise,

11557-427: The larger hilltop settlements, and the elite using violence in practical and ideological terms to clamp down on the population. Ecological degradation, landscape opening, fires, pastoralism, and maybe tree cutting for mining have been suggested as reasons for the collapse. The culture of the motillas developed an early system of groundwater supply plants (the so-called motillas ) in the upper Guadiana basin (in

11684-429: The last Marinid attempt to set up a power base in the Iberian Peninsula. The lasting consequences of the resounding Muslim defeat to an alliance of Castile and Portugal with naval support from Aragon and Genoa ensured Christian supremacy over the Iberian Peninsula and the preeminence of Christian fleets in the Western Mediterranean. The 1348–1350 bubonic plague devastated large parts of the Iberian Peninsula, leading to

11811-409: The literature. Several international organizations like IUPAC and CAS have initiated steps to make such tasks easier. CAS provides the abstracting services of the chemical literature, and provides a numerical identifier, known as CAS registry number to each chemical substance that has been reported in the chemical literature (such as chemistry journals and patents ). This information is compiled as

11938-456: The meanings of the words, including Iber, must also remain unknown. In modern Basque , the word ibar means "valley" or "watered meadow", while ibai means "river", but there is no proof connecting the names with Ebro or Iberia . The word Iberia comes from the Latin word Hiberia originating from the Ancient Greek word Ἰβηρία ( Ibēríā ), used by Greek geographers under

12065-453: The mediterranean slave trade, with Barcelona (already in the 14th century), Valencia (particularly in the 15th century) and, to a lesser extent, Palma de Mallorca (since the 13th century), becoming dynamic centres in this regard, involving chiefly eastern and Muslim peoples. Castile engaged later in this economic activity, rather by adhering to the incipient atlantic slave trade involving sub-saharan people thrusted by Portugal (Lisbon being

12192-411: The metallic properties described above, they also have a high electronegativity and a tendency to form negative ions . Certain elements such as silicon sometimes resemble metals and sometimes resemble non-metals, and are known as metalloids . A chemical compound is a chemical substance that is composed of a particular set of atoms or ions . Two or more elements combined into one substance through

12319-546: The northeastern Ebro Valley and beyond. The threat to Roman interests posed by Celtiberians and Lusitanians in uncontrolled territories lingered in. Further wars of indigenous resistance, such as the Celtiberian Wars and the Lusitanian War , were fought in the 2nd century. Urban growth took place, and population progressively moved from hillforts to the plains. An example of the interaction of slaving and ecocide ,

12446-399: The patent holder. Pharmaceutical drugs are usually categorised into drug classes . A group of drugs will share a similar chemical structure , or have the same mechanism of action , the same related mode of action or target the same illness or related illnesses. The Anatomical Therapeutic Chemical Classification System (ATC), the most widely used drug classification system, assigns drugs

12573-503: The peninsula in 1146. Somewhat straying from the trend taking place in other locations of the Latin West since the 10th century, the period comprising the 11th and 13th centuries was not one of weakening monarchical power in the Christian kingdoms. The relatively novel concept of "frontier" (Sp: frontera ), already reported in Aragon by the second half of the 11th century become widespread in

12700-756: The peninsula's first civilizations and to extensive exchange networks reaching to the Baltic , Middle East and North Africa . Around 2800 – 2700 BCE, the Beaker culture , which produced the Maritime Bell Beaker , probably originated in the vibrant copper-using communities of the Tagus estuary and spread from there to many parts of western Europe. The Bronze Age began on the Iberian Peninsula in 2100 cal. BC according to radiocarbon datings of several key sites. Bronze Age cultures developed beginning c.  1800 BCE, when

12827-523: The peninsula, possibly as early as the 5th millennium BCE. These people may have had some relation to the subsequent development of the Iberian civilization . As is the case for most of the rest of Southern Europe, the principal ancestral origin of modern Iberians are Early European Farmers who arrived during the Neolithic. The large predominance of Y-Chromosome Haplogroup R1b, common throughout Western Europe ,

12954-407: The possible origin of the word in {ḥṭr} an early romanized form of Al-Andalus language from Northwestern part of the Iberian peninsula . The term could approximately be transcribed as حطروكة or hatruka . The term "drug" has become a skunked term with negative connotation, being used as a synonym for illegal substances like cocaine or heroin or for drugs used recreationally . In other contexts

13081-457: The present southern Spain to the present southern France along the Mediterranean coast, is marked by instances of a readable script expressing a yet unknown language, dubbed " Iberian ". Whether this was the native name or was given to them by the Greeks for their residence near the Ebro remains unknown. Credence in Polybius imposes certain limitations on etymologizing: if the language remains unknown,

13208-456: The proviso that it can only be used for personal use. It can be used in the leaf form of marijuana (grass) , or in the resin form of hashish . Marijuana is a more mild form of cannabis than hashish. There may be an age restriction on the consumption and purchase of legal recreational drugs. Some recreational drugs that are legal and accepted in many places include alcohol , tobacco , betel nut , and caffeine products, and in some areas of

13335-410: The realm of organic chemistry ; the discovery of many more chemical elements and new techniques in the realm of analytical chemistry used for isolation and purification of elements and compounds from chemicals that led to the establishment of modern chemistry , the concept was defined as is found in most chemistry textbooks. However, there are some controversies regarding this definition mainly because

13462-494: The relationship between the quantities of methane and oxygen that react to form carbon dioxide and water. Because of the well known relationship of moles to atomic weights , the ratios that are arrived at by stoichiometry can be used to determine quantities by weight in a reaction described by a balanced equation. This is called composition stoichiometry . Iberian Peninsula The Iberian Peninsula ( IPA : / aɪ ˈ b ɪər i ə n / ), also known as Iberia ,

13589-559: The remaining taifas. The Almoravids in the Iberian peninsula progressively relaxed strict observance of their faith, and treated both Jews and Mozarabs harshly, facing uprisings across the peninsula, initially in the Western part. The Almohads , another North-African Muslim sect of Masmuda Berber origin who had previously undermined the Almoravid rule south of the Strait of Gibraltar, first entered

13716-677: The route of administration Numerous governmental offices in many countries deal with the control and supervision of drug manufacture and use, and the implementation of various drug laws. The Single Convention on Narcotic Drugs is an international treaty brought about in 1961 to prohibit the use of narcotics save for those used in medical research and treatment. In 1971, a second treaty the Convention on Psychotropic Substances had to be introduced to deal with newer recreational psychoactive and psychedelic drugs. The legal status of Salvia divinorum varies in many countries and even in states within

13843-555: The rule of the Roman Empire to refer to what is known today in English as the Iberian Peninsula. At that time, the name did not describe a single geographical entity or a distinct population; the same name was used for the Kingdom of Iberia , natively known as Kartli in the Caucasus , the core region of what would later become the Kingdom of Georgia . It was Strabo who first reported

13970-457: The southern meseta ) in a context of extreme aridification in the area in the wake of the 4.2-kiloyear climatic event , which roughly coincided with the transition from the Copper Age to the Bronze Age. Increased precipitation and recovery of the water table from about 1800 BC onward should have led to the forsaking of the motillas (which may have flooded) and the redefinition of the relation of

14097-650: The species Homo erectus , Homo heidelbergensis , or a new species called Homo antecessor . Around 200,000 BP , during the Lower Paleolithic period, Neanderthals first entered the Iberian Peninsula. Around 70,000 BP, during the Middle Paleolithic period, the last glacial event began and the Neanderthal Mousterian culture was established. Around 37,000 BP, during the Upper Paleolithic ,

14224-454: The synthesis of more complex molecules targeted for single use, as named above. The production of a chemical includes not only its synthesis but also its purification to eliminate by-products and impurities involved in the synthesis. The last step in production should be the analysis of batch lots of chemicals in order to identify and quantify the percentages of impurities for the buyer of the chemicals. The required purity and analysis depends on

14351-462: The terms "drug" and "medicine" are used interchangeably. Drug action is highly specific and their effects may only be detected in certain individuals. For instance, the 10 highest-grossing drugs in the US may help only 4-25% of people. Often, the activity of a drug depends on the genotype of a patient. For example, Erbitux ( cetuximab ) increases the survival rate of colorectal cancer patients if they carry

14478-549: The terms 'Spanish Peninsula' or 'Pyrenaean Peninsula'. The Iberian Peninsula has been inhabited by members of the Homo genus for at least 1.2 million years as remains found in the sites in the Atapuerca Mountains demonstrate. Among these sites is the cave of Gran Dolina , where six hominin skeletons, dated between 780,000 and one million years ago, were found in 1994. Experts have debated whether these skeletons belong to

14605-507: The time of the late Roman Republic called the entire peninsula Hispania . In Greek and Roman antiquity, the name Hesperia was used for both the Italian and Iberian Peninsula; in the latter case Hesperia Ultima (referring to its position in the far west) appears as form of disambiguation from the former among Roman writers. Also since Roman antiquity, Jews gave the name Sepharad to the peninsula. As they became politically interested in

14732-434: The use of different recreational drugs; medicinal drugs that have the potential for recreational use are often heavily regulated. However, there are many recreational drugs that are legal in many jurisdictions and widely culturally accepted. Cannabis is the most commonly consumed controlled recreational drug in the world (as of 2012). Its use in many countries is illegal but is legally used in several countries usually with

14859-543: The view of Jaime Vicens Vives , "the most powerful state in Europe". Abd-ar-Rahman III also managed to expand the clout of Al-Andalus across the Strait of Gibraltar, waging war, as well as his successor, against the Fatimid Empire . Between the 8th and 12th centuries, Al-Andalus enjoyed a notable urban vitality, both in terms of the growth of the preexisting cities as well as in terms of founding of new ones: Córdoba reached

14986-598: The vulnerable peyote. The entheogenic use of cannabis has also been widely practised for centuries. Rastafari use marijuana (ganja) as a sacrament in their religious ceremonies . Psychedelic mushrooms ( psilocybin mushrooms ), commonly called magic mushrooms or shrooms have also long been used as entheogens. Nootropics , also commonly referred to as "smart drugs", are drugs that are claimed to improve human cognitive abilities . Nootropics are used to improve memory, concentration, thought, mood, and learning. An increasingly used nootropic among students, also known as

15113-544: The western portion of the Pyrenees. As early as the 12th century BCE, the Phoenicians , a thalassocratic civilization originally from the Eastern Mediterranean, began to explore the coastline of the peninsula, interacting with the metal-rich communities in the southwest of the peninsula (contemporarily known as the semi-mythical Tartessos ). Around 1100 BCE, Phoenician merchants founded the trading colony of Gadir or Gades (modern day Cádiz ). Phoenicians established

15240-484: The western province of al-Andalus was marginalised and ultimately became politically autonomous as independent emirate in 756, ruled by one of the last surviving Umayyad royals, Abd al-Rahman I . Al-Andalus became a center of culture and learning, especially during the Caliphate of Córdoba . The Caliphate reached the height of its power under the rule of Abd-ar-Rahman III and his successor al-Hakam II , becoming then, in

15367-667: The words was because of an overlapping in political and geographic perspectives. The Latin word Hiberia , similar to the Greek Iberia , literally translates to "land of the Hiberians". This word was derived from the river Hiberus (now called Ebro or Ebre). Hiber (Iberian) was thus used as a term for peoples living near the river Ebro. The first mention in Roman literature was by the annalist poet Ennius in 200 BCE. Virgil wrote impacatos (H)iberos ("restless Iberi") in his Georgics . Roman geographers and other prose writers from

15494-466: The world the legal use of drugs such as khat is common. There are a number of legal intoxicants commonly called legal highs that are used recreationally. The most widely used of these is alcohol. All drugs have a route of administration , and many can be administered by more than one. A bolus is the administration of a medication, drug or other compound that is given to raise its concentration in blood rapdily to an effective level, regardless of

15621-475: The world. The most widely used drugs in the world include caffeine , nicotine and alcohol , which are also considered recreational drugs , since they are used for pleasure rather than medicinal purposes. All drugs can have potential side effects . Abuse of several psychoactive drugs can cause addiction and/or physical dependence . Excessive use of stimulants can promote stimulant psychosis . Many recreational drugs are illicit ; international treaties such as

15748-717: Was a recurrent causal for strife, rivalry and hatred, particularly between Arabs and Berbers. Arab elites could be further divided in the Yemenites (first wave) and the Syrians (second wave). Christians and Jews were allowed to live as part of a stratified society under the dhimmah system , although Jews became very important in certain fields. Some Christians migrated to the Northern Christian kingdoms, while those who stayed in Al-Andalus progressively arabised and became known as musta'arab ( mozarabs ). The slave population comprised

15875-639: Was ambiguous, being also the name of the Kingdom of Iberia in the Caucasus.) Whatever languages may generally have been spoken on the peninsula soon gave way to Latin, except for that of the Vascones , which was preserved as a language isolate by the barrier of the Pyrenees. The modern phrase "Iberian Peninsula" was coined by the French geographer Jean-Baptiste Bory de Saint-Vincent on his 1823 work "Guide du Voyageur en Espagne" . Prior to that date, geographers had used

16002-540: Was seen as a critical event at the time, entailing also a huge territorial expansion, advancing from the Sistema Central to La Mancha . In 1086, following the siege of Zaragoza by Alfonso VI of León-Castile, the Almoravids , religious zealots originally from the deserts of the Maghreb, landed in the Iberian Peninsula, and, having inflicted a serious defeat to Alfonso VI at the battle of Zalaca , began to seize control of

16129-453: Was subsumed in a period of upheaval and civil war (the Fitna of al-Andalus ) and collapsed in the early 11th century, spawning a series of ephemeral statelets, the taifas . Until the mid 11th century, most of the territorial expansion southwards of the Kingdom of Asturias/León was carried out through a policy of agricultural colonization rather than through military operations; then, profiting from

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