17-457: [REDACTED] Look up dop in Wiktionary, the free dictionary. DOP may stand for: Science-related [ edit ] Data-oriented parsing Degree of parallelism Degree of polarization Delta-opioid receptor Dermo-optical perception Dilution of precision (navigation) , a term used in geomatics engineering to describe
34-670: A non-selective agonist of the α- and β-adrenergic receptors . Unlike norepinephrine, but similarly to levodopa ( L -DOPA), droxidopa is capable of crossing the protective blood–brain barrier (BBB). Droxidopa was first described by 1971. It was approved for use in Japan in 1989 and was introduced in the United States in 2014. Droxidopa is approved for use in the treatment of orthostatic hypotension , intradialytic hypotension (IDH; hemodialysis -induced hypotension ), dizziness , and amyloid polyneuropathy . For hypotension, it
51-559: A merger with Dainippon Pharmaceuticals in 2006, Dainippon Sumitomo Pharma licensed droxidopa to Chelsea Therapeutics to develop and market it worldwide except in Japan, Korea , China , and Taiwan . In February 2014, the United States Food and Drug Administration approved droxidopa for the treatment of symptomatic neurogenic orthostatic hypotension. A systematic review and meta-analysis conducted on clinical trials comparing
68-486: A peripheral aromatic L -amino acid decarboxylase inhibitor (AAADI) or DOPA decarboxylase inhibitor (DDC) such as carbidopa (Lodosyn) to increase central norepinephrine concentrations while minimizing increases of peripheral levels. Droxidopa, also known as (–)- threo -3-(3,4-dihydroxyphenyl)- L -serine ( L -DOPS), is a substituted phenethylamine and is chemically analogous to levodopa ( L -3,4-dihydroxyphenylalanine; L -DOPA). Whereas levodopa functions as
85-483: A precursor and prodrug to dopamine , droxidopa is a precursor and prodrug of norepinephrine . Droxidopa was first described in the scientific literature by 1971. Droxidopa was developed by Sumitomo Pharmaceuticals for the treatment of hypotension , including NOH, and NOH associated with various disorders such as MSA, FAP, and PD, as well as IDH. The drug has been used in Japan and some surrounding Asian areas for these indications since 1989. Following
102-421: Is a prodrug of norepinephrine used to increase the concentrations of these neurotransmitters in the body and brain . It is metabolized by aromatic L -amino acid decarboxylase (AAAD), also known as DOPA decarboxylase (DDC). Patients with NOH have depleted levels of norepinephrine which leads to decreased blood pressure or hypotension upon orthostatic challenge. Droxidopa works by increasing
119-1121: Is different from Wikidata All article disambiguation pages All disambiguation pages dop [REDACTED] Did you mean: Dops ? Look for Dop on one of Misplaced Pages's sister projects : [REDACTED] Wiktionary (dictionary) [REDACTED] Wikibooks (textbooks) [REDACTED] Wikiquote (quotations) [REDACTED] Wikisource (library) [REDACTED] Wikiversity (learning resources) [REDACTED] Commons (media) [REDACTED] Wikivoyage (travel guide) [REDACTED] Wikinews (news source) [REDACTED] Wikidata (linked database) [REDACTED] Wikispecies (species directory) Misplaced Pages does not have an article with this exact name. Please search for Dop in Misplaced Pages to check for alternative titles or spellings. You need to log in or create an account and be autoconfirmed to create new articles. Alternatively, you can use
136-668: Is specifically used in the treatment of neurogenic orthostatic hypotension (NOH) in dopamine β-hydroxylase deficiency , as well as NOH associated with multiple system atrophy (MSA), familial amyloid polyneuropathy (FAP), and pure autonomic failure (PAF). The drug is also used off-label in the treatment of freezing of gait in Parkinson's disease . With over 20 years on the market, droxidopa has proven to have few side effects of which most are mild. The most common side effects reported in clinical trials include headache, dizziness, nausea, hypertension and fatigue. Droxidopa
153-458: The article wizard to submit a draft for review, or request a new article . Search for " Dop " in existing articles. Look for pages within Misplaced Pages that link to this title . Other reasons this message may be displayed: If a page was recently created here, it may not be visible yet because of a delay in updating the database; wait a few minutes or try the purge function . Titles on Misplaced Pages are case sensitive except for
170-1223: The CE marking Declaration of Principles, an agreement between Israel and Palestine, also known as the Oslo Accords Denominazione di Origine Protetta , the Italian equivalent of protected designation of origin Diocese of Parañaque Director of photography , alternate name for cinematographer Dolpa Airport , IATA airport code Dominican peso , by ISO 4217 currency code dOP (band) , an electronic music group Dumbarton Oaks Papers , an academic journal founded in 1941 Dingzhou East railway station , China Railway telegraph code DOP See also [ edit ] [REDACTED] Search for "dop" , "do-p" , "d-op" , or "d-o-p" on Misplaced Pages. All pages with titles beginning with Dop All pages with titles beginning with DOP All pages with titles containing DOP Doop (disambiguation) Dopp (disambiguation) dops Doping (disambiguation) Dopping (disambiguation) Topics referred to by
187-473: The brand names Northera and Dops among others, is sympathomimetic medication which is used in the treatment of hypotension (low blood pressure) and for other indications. It is taken by mouth . Side effects of droxidopa include headache , dizziness , nausea , and hypertension , among others. Droxidopa is a synthetic amino acid precursor which acts as a prodrug to the neurotransmitter norepinephrine (noradrenaline). Hence, it acts as
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#1732849014011204-493: The clinical use of droxidopa and midodrine have found that midodrine was more likely to cause supine hypertension than droxidopa in patients with NOH. Midodrine was also found to be slightly more effective at raising blood pressure but not statistically significantly. Chelsea Therapeutics obtained orphan drug status (ODS) for droxidopa in the US for NOH, and that of which associated with PD, PAF, and MSA. In 2014, Chelsea Therapeutics
221-408: The first character; please check alternative capitalizations and consider adding a redirect here to the correct title. If the page has been deleted, check the deletion log , and see Why was the page I created deleted? Retrieved from " https://en.wikipedia.org/wiki/Dop " Dops Droxidopa , also known as L - threo -dihydroxyphenylserine ( L -DOPS ) and sold under
238-429: The geometric strength of satellite configuration Dioctyl phthalate , alternate name of Bis(2-ethylhexyl) phthalate, a PVC plasticizer Discrete oriented polytope or polyhedron in computer graphics DSD over PCM, a protocol for Direct Stream Digital audio Other [ edit ] Declaration of Performance , a document issued by a manufacturer of a construction product required by EU regulations to attach
255-434: The levels of norepinephrine in the peripheral nervous system (PNS), thus enabling the body to maintain blood flow upon and while standing . Droxidopa can also cross the blood–brain barrier (BBB) where it is converted to norepinephrine from within the brain. Increased levels of norepinephrine in the central nervous system (CNS) may be beneficial to patients in a wide range of indications. Droxidopa can be coupled with
272-403: The same term [REDACTED] This disambiguation page lists articles associated with the title DOP . If an internal link led you here, you may wish to change the link to point directly to the intended article. Retrieved from " https://en.wikipedia.org/w/index.php?title=DOP&oldid=1183148113 " Category : Disambiguation pages Hidden categories: Short description
289-519: Was acquired by Lundbeck along with the rights to droxidopa which was launched in the US in Sept 2014. Droxidopa is the generic name of the drug and its INN Tooltip International Nonproprietary Name and JAN Tooltip Japanese Accepted Name . Brand names of droxidopa include Dops and Northera . Droxidopa alone and in combination with carbidopa has been studied in the treatment of attention deficit hyperactivity disorder (ADHD). Droxidopa
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