2-416: DMBMPP , or 2-(2,5-dimethoxy-4-bromobenzyl)-6-(2-methoxyphenyl)piperidine , is a 2-benzylpiperidine analog of the hallucinogenic N -benzylphenethylamine 25B-NBOMe and was discovered in 2011 by Jose Juncosa in the group of David E. Nichols at Purdue University . DMBMPP differs from 25B-NBOMe by incorporating the amine within a piperidine ring, making for a more rigid molecular structure than that of
4-480: The open-chain 25B-NBOMe. The presence of the piperidine ring introduces two stereocenters, thus, four stereoisomers of this compound can be made. The ( S , S )-isomer ((2 S ,6 S )-DMBMPP) is the most selective agonist for the human 5-HT 2A receptor yet discovered, with a K i of 2.5 nM at the human 5-HT 2A receptor and with 124-fold selectivity for 5-HT 2A over the structurally similar 5-HT 2C -receptor . Together with 25CN-NBOH , (2 S ,6 S )-DMBMPP
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