39-449: Centron may refer to: a brand name for ormeloxifene Centron Corporation , a former industrial and educational film production company Centron (weevil) , a beetle genus in the tribe Alophini Topics referred to by the same term [REDACTED] This disambiguation page lists articles associated with the title Centron . If an internal link led you here, you may wish to change
78-545: A cause of infertility or ectopic pregnancy . If a blocked fallopian tube has affected fertility, its repair where possible may increase the chances of becoming pregnant. Tubal obstruction can be proximal, distal or mid-segmental . Tubal obstruction is a major cause of infertility but full testing of tubal functions is not possible. However, the testing of patency – whether or not the tubes are open can be carried out using hysterosalpingography , laparoscopy and dye , or hystero contrast sonography (HyCoSy). During surgery,
117-417: A daily schedule required by other oral contraceptives. For the first twelve weeks of use, it is advised to take the ormeloxifene pill twice per week. From the thirteenth week on, it is taken once per week. The consensus is that backup protection in the first month is a cautious but sensible choice. A standard dose is 30 mg weekly, but 60 mg loading doses can reduce pregnancy rates by 38%. It has
156-460: A failure rate of about 1-2% with ideal use which is slightly less effective than found for combined oral contraceptive pills . There are concerns that ormeloxifene may cause delayed menstruation . Ormeloxifene is a selective estrogen receptor modulator (SERM). In some parts of the body, its action is estrogenic (e.g., bones ), in other parts of the body, its action is antiestrogenic (e.g., uterus , breasts ). It causes an asynchrony in
195-403: A length of 5 cm. It curves over the ovary, and is the primary site of fertilization. The ampulla contains a large number of ciliated epithelial cells. It is thin walled with a much folded luminal surface, and opens into the infundibulum. The infundibulum opens into the abdomen at the distal tubal opening and rests above the ovary. Most cells here are ciliated epithelial cells. The opening
234-413: A proximal opening nearest to the uterus, and a distal opening nearest to the ovary. The fallopian tubes are held in place by the mesosalpinx , a part of the broad ligament mesentery that wraps around the tubes. Another part of the broad ligament, the mesovarium suspends the ovaries in place. An egg cell is transported from an ovary to a fallopian tube where it may be fertilized in the ampulla of
273-481: A third of cases of infertility are caused by fallopian tube pathologies. These include inflammation , and tubal obstructions . A number of tubal pathologies cause damage to the cilia of the tube, which can impede movement of the sperm or egg. The name comes from the Italian Catholic priest and anatomist Gabriele Falloppio , for whom other anatomical structures are also named. Each fallopian tube leaves
312-401: Is tubal ligation . Fallopian tube cancer , which typically arises from the epithelial lining of the fallopian tube, has historically been considered to be a very rare malignancy. Evidence suggests it probably represents a significant portion of what has previously been classified as ovarian cancer , as much as 80 per cent. These are classed as serous carcinomas , and are usually located in
351-441: Is 0.7 mm wide and 1 cm long. The narrow isthmus links the tube to the uterus, and connects to the ampulla. The isthmus is a rounded, and firm muscular part of the tube. The isthmus is 1–5 mm wide, and 3 cm long. The isthmus contains a large number of secretory cells. The ampulla is the major part of the fallopian tube. The ampulla is the widest part of the tube with a maximal luminal diameter of 1 cm, and
390-419: Is able to become fertilized with sperm. The ampulla is typically where the sperm are met and fertilization occurs; meiosis II is promptly completed. After fertilization, the ovum is now called a zygote and travels toward the uterus with the aid of the hairlike cilia and the activity of the muscle of the fallopian tube. The early embryo requires critical development in the fallopian tube. After about five days,
429-427: Is about to occur, the sex hormones activate the fimbriae, causing them to swell with blood, extend, and hit the ovary in a gentle, sweeping motion. An oocyte is released from the ovary into the peritoneal cavity and the cilia of the fimbriae sweep it into the fallopian tube. When viewed under the microscope , the fallopian tube has three layers. From outer to inner, these are the serosa , muscularis mucosae , and
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#1733116933017468-536: Is one of the selective estrogen receptor modulators , or SERMs, a class of medication which acts on the estrogen receptor . It is best known as a nonsteroidal oral contraceptive which is taken once per week. In India, ormeloxifene has been available as birth control since the early 1990s, and it was marketed there under the trade name Saheli , currently available free-of-cost for the women in India as Chhaya (Centchroman) . Ormeloxifene has also been licensed under
507-459: Is provided free-of-cost to the women in India by the government under the brand name Chhaya . As of 2009, ormeloxifene was legally available only in India. Ormeloxifene has been tested and licensed as a form of birth control, as well as a treatment for dysfunctional uterine bleeding. Fallopian tube The fallopian tubes , also known as uterine tubes , oviducts or salpinges ( sg. : salpinx ), are paired tubular sex organs in
546-404: Is surrounded by fimbriae , which help in the collection of the oocyte after ovulation. The fimbriae (singular fimbria) is a fringe of densely ciliated tissue projections of approximately 1 mm in width around the distal tubal opening, oriented towards the ovary. They are attached to the ends of the infundibulum, extending from its inner circumference, and muscular wall. The cilia beat towards
585-627: The fallopian tubes more quickly than is normal. Presumably, this combination of effects creates an environment such that if fertilization occurs, implantation will not be possible. Ormeloxifene was first discovered by Central Drug Research Institute (CDRI) in Lucknow , India. Ormeloxifene was marketed in Delhi in July 1991 and in India in 1992, under the brand names Saheli and Choice-7 . Since 2018, Centchroman
624-403: The menstrual cycle between ovulation and the development of the uterine lining, although its exact mode of action is not well defined. In clinical trials, it caused ovulation to occur later than it normally would in some women, but did not affect ovulation in the majority of women, while causing the lining of the uterus to build more slowly. It speeds the transport of any fertilized egg through
663-412: The mucosa . The outermost covering layer of serous membrane is known as the serosa. The serosa is derived from the visceral peritoneum . The muscularis mucosae consists of an outer ring of smooth muscle arranged longitudinally, and a thick inner circular ring of smooth muscle. This layer is responsible for the rhythmic peristaltic contractions of the fallopian tubes, that with the cilia move
702-498: The Müllerian duct. A second duct, the mesonephric duct , develops adjacent to this. Both ducts become longer over the next two weeks, and the paramesonephric ducts around the eighth week cross to meet in the midline and fuse. One duct then regresses, with this depending on whether the embryo is genetically female or male . In females, the paramesonephric duct remains, and eventually forms the female reproductive tract. The portions of
741-427: The ampulla contains an extensive array of complex folds, whereas the relatively narrow isthmus has a thick muscular coat and simple mucosal folds. Embryos develop a genital ridge that forms at their tail end and eventually forms the basis for the urinary system and reproductive tracts . Either side and to the front of this tract, around the sixth week develops a duct called the paramesonephric duct , also called
780-450: The body when they are adults; the Müllerian ducts develop in females into the fallopian tubes, uterus, and vagina . The fallopian tube allows the passage of an egg from the ovary to the uterus. When an oocyte is developing in an ovary, it is surrounded by a spherical collection of cells known as an ovarian follicle . Just before ovulation, the primary oocyte completes meiosis I to form
819-516: The cilia of the tube, which can impede movement of the sperm or egg. A number of sexually transmitted infections can lead to infertility. Salpingitis is inflammation of the fallopian tubes and may be found alone, or with other pelvic inflammatory diseases (PIDs). A thickening of the fallopian tube at its narrow isthmus portion, due to inflammation, is known as salpingitis isthmica nodosa . Like another PID endometriosis , it may lead to fallopian tube obstruction . Fallopian tube obstruction may be
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#1733116933017858-470: The condition of the tubes may be inspected and a dye such as methylene blue can be injected into the uterus and shown to pass through the tubes when the cervix is occluded. As tubal disease is often related to Chlamydia infection , testing for Chlamydia antibodies has become a cost-effective screening device for tubal pathology. Occasionally the embryo implants outside of the uterus, creating an ectopic pregnancy . Most ectopic pregnancies occur in
897-433: The egg cell towards the uterus. The innermost mucosa is made up of a layer of luminal epithelium, and an underlying thin layer of loose connective tissue the lamina propria . There are three different cell types in the epithelium. Around 25% of the cells are ciliated columnar cells; around 60% are secretory cells, and the rest are peg cells thought to be a secretory cell variant. The ciliated cells are most numerous in
936-401: The fallopian tube in the human . The fallopian tubes are held in place by the mesosalpinx a part of the broad ligament mesentery that wraps around the tubes. Another part of the broad ligament, the mesovarium suspends the ovaries in place. Each tube is composed of four parts: from inside the proximal tubal opening the intramural or interstitial part, that links to the narrow isthmus,
975-452: The fallopian tube, and are commonly known as tubal pregnancies . The surgical removal of a fallopian tube is called a salpingectomy . To remove both tubes is a bilateral salpingectomy. An operation that combines the removal of a fallopian tube with the removal of at least one ovary is a salpingo-oophorectomy . An operation to remove a fallopian tube obstruction is called a tuboplasty . A surgical procedure to permanently prevent conception
1014-413: The fallopian tube. Of all the fimbriae, one fimbria known as the ovarian fimbria is long enough to reach and make contact with the near part of the ovary during ovulation. The fimbriae have a higher density of blood vessels than the other parts of the tube, and the ovarian fimbria is seen to have an even higher density. An ovary is not directly connected to its adjacent fallopian tube. When ovulation
1053-501: The fallopian tubes, the fimbriae, develop over time. Cell markers have been identified in the fimbriae, which suggests that their embryonic origin is different from that of the other tube segments. Apart from the presence of sex chromosomes, specific genes associated with the development of the fallopian tubes include the Wnt and Hox groups of genes, Lim1 , Pax2 , and Emx2 . Embryos have two pairs of ducts that will let gametes out of
1092-400: The fimbriated distal tube. In rare cases, a fallopian tube may prolapse into the vaginal canal following a hysterectomy . The swollen fimbriae can have the appearance of an adenocarcinoma . The Greek doctor Herophilus, in his treatise on midwifery, points out the existence of the two ducts that he supposed transported "female semen". Then Galen, already in the modern era, described that
1131-401: The first polar body and a secondary oocyte, which is arrested in metaphase of meiosis II . At the time of ovulation in the menstrual cycle , the secondary oocyte is released from the ovary. The follicle and the ovary's wall rupture, allowing the secondary oocyte to escape. The secondary oocyte is caught by the fimbriated end of the fallopian tube and travels to the ampulla. Here, the egg
1170-508: The human female body that stretch from the ovaries to the uterus . The fallopian tubes are part of the female reproductive system . In other vertebrates, they are only called oviducts . Each tube is a muscular hollow organ that is on average between 10 and 14 cm (3.9 and 5.5 in) in length, with an external diameter of 1 cm (0.39 in). It has four described parts: the intramural part, isthmus, ampulla, and infundibulum with associated fimbriae. Each tube has two openings:
1209-469: The infundibulum, and the ampulla. Estrogen increases the formation of cilia on these cells. Peg cells are shorter, have surface microvilli , and are located between the other epithelial cells. The presence of immune cells in the mucosa has also been reported with the main type being CD8 T-cells . Other cells found are B lymphocytes , macrophages , NK cells , and dendritic cells . The histological features of tube vary along its length. The mucosa of
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1248-421: The isthmus connects to the larger ampulla, which connects with the infundibulum and its associated fimbriae that opens into the peritoneal cavity from the distal tubal opening. The intramural part or interstitial part of the fallopian tube lies in the myometrium , the muscular wall of the uterus. This is the narrowest part of the tube that crosses the uterus wall to connect with the isthmus. The intramural part
1287-405: The link to point directly to the intended article. Retrieved from " https://en.wikipedia.org/w/index.php?title=Centron&oldid=612473668 " Category : Disambiguation pages Hidden categories: Short description is different from Wikidata All article disambiguation pages All disambiguation pages Ormeloxifene Ormeloxifene , also known as centchroman ,
1326-474: The new embryo enters the uterine cavity and, on about the sixth day, begins to implant on the wall of the uterus. The release of an oocyte does not alternate between the two ovaries and seems to be random. After removal of an ovary, the remaining one produces an egg every month. Almost a third of cases of infertility are caused by fallopian tube pathologies. These include inflammation, and tubal obstructions . A number of tubal pathologies cause damage to
1365-469: The paired ducts indicated by Herophilus were connected to the uterus. In 1561, the Renaissance doctor Gabriele Falloppio published his book Observationes Anatomicae . Its contribution is a detailed description of the "tubal" of the uterus and its different portions, with its farthest (distal) end open towards the abdomen, and the other (proximal) connected to the uterus. Though the name Fallopian tube
1404-408: The paramesonephric duct, which are more cranial —that is, further from the tail-end, end up forming the fallopian tubes. In males, because of the presence of the Y sex chromosome , anti-Müllerian hormone is produced. This leads to the degeneration of the paramesonephric duct. As the uterus develops, the part of the fallopian tubes closer to the uterus, the ampulla, becomes larger. Extensions from
1443-400: The trade names Ormalin , Novex-DS , Centron , and Sevista . Ormeloxifene is primarily used as a contraceptive but may also be effective for dysfunctional uterine bleeding and advanced breast cancer . Ormeloxifene may be used as a weekly oral contraceptive. The weekly schedule is an advantage for women who prefer an oral contraceptive, but find it difficult or impractical to adhere to
1482-400: The tube. The fallopian tubes are lined with simple columnar epithelium with hairlike extensions called cilia , which together with peristaltic contractions from the muscular layer, move the fertilized egg (zygote) along the tube. On its journey to the uterus, the zygote undergoes cell divisions that changes it to a blastocyst , an early embryo, in readiness for implantation . Almost
1521-434: The uterus at an opening at the uterine horns known as the proximal tubal opening or proximal ostium . The tubes have an average length of 10–14 centimeters (3.9–5.5 in) that includes the intramural part of the tube. The tubes extend to near the ovaries where they open into the abdomen at the distal tubal openings . In other mammals , the fallopian tube is called the oviduct , which may also be used in reference to
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