48-501: CGN may refer to: CGN, a gene that encodes for the protein cingulin Ceredigion , formerly Cardiganshire , historic county in Wales, Chapman code China General Nuclear Power Group , a Chinese energy company Compagnie Générale de Navigation sur le lac Léman , a Swiss company operating boats on Lake Léman Childhood gender nonconformity ,
96-513: A syndrome of the kidney that is characterized by a rapid loss of kidney function Topics referred to by the same term [REDACTED] This disambiguation page lists articles associated with the title CGN . If an internal link led you here, you may wish to change the link to point directly to the intended article. Retrieved from " https://en.wikipedia.org/w/index.php?title=CGN&oldid=1218756637 " Category : Disambiguation pages Hidden categories: Short description
144-417: A central nervous system arising from a single nerve cord dorsal to the gut tube , headed by a series of (typically paired) brain vesicles, is unique to vertebrates. This is in stark contrast to invertebrates with well-developed central nervous systems such as arthropods and cephalopods , which have an often ladder-like ventral nerve cord made of paired segmental ganglia on the opposite ( ventral ) side of
192-499: A childhood behavioral pattern CGN, IATA code for Cologne Bonn Airport , Germany CGN, National Rail station code for Cogan railway station , Wales CGN, U.S. Navy designation for a nuclear-powered guided missile cruiser Carrier-grade NAT , an approach to IPv4 network design where end sites are configured with private network addresses CGN, cis Golgi network, compartment of the Golgi apparatus Crescentic glomerulonephritis ,
240-525: A hollow neural tube ) running along the dorsal aspect of the notochord . Of particular importance and unique to vertebrates is the presence of neural crest cells, which are progenitor cells critical to coordinating the functions of cellular components. Neural crest cells migrate through the body from the dorsal nerve cord during development, initiate the formation of neuronal ganglia and various special sense organs. The peripheral nervous system forms when neural crest cells branch out laterally from
288-418: A large number of genes, including tight junction protein genes ( claudin-2 , claudin-6 , claudin-7 and occludin ) and transcription factors (including GATA4 ). Changes in the expression of claudin-2 and ZO-3 are also observed in cultured kidney cells (MDCK) depleted of cingulin by shRNA . In 2012, the phenotype of cingulin-knockout mice was described, proving that functional TJ in vivo can be formed in
336-485: A marker of epithelial differentiation, and as a diagnostic marker to distinguish adenocarcinomas from squamous carcinomas. Vertebrates Ossea Batsch, 1788 Vertebrates ( / ˈ v ɜːr t ə b r ɪ t s , - ˌ b r eɪ t s / ) are animals with a backbone or spine, consisting of vertebrae and intervertebral discs . The vertebrae are irregular bones , and the intervertebral discs are of fibrocartilage . The vertebral column surrounds and protects
384-589: A protein related to ubiquitin carboxyl-terminal hydrolase are exclusively shared by all vertebrates and reliably distinguish them from all other animals. A specific relationship between vertebrates and tunicates is strongly supported by two CSIs found in the proteins Rrp44 (associated with the exosome complex ) and serine palmitoyltransferase . These are exclusively shared by species from these two subphyla, but not cephalochordates . This indicates hat vertebrates are more closely related to tunicates than cephalochordates. The "Notochordata hypothesis" suggested that
432-449: A small globular C-terminal "tail" region. This organization is highly conserved throughout vertebrates . However, cingulin homologs have not been detected in invertebrates . In vitro , cingulin can bind to and bundle actin filaments, and interact with myosin II and several TJ proteins including ZO-1, ZO-2, ZO-3, paracingulin and occludin . Moreover, cingulin forms a complex with JAM-A,
480-534: A tight junction membrane protein. Most of cingulin protein interactions are through the globular head domain. Cingulin interacts with ZO-1 through an N-terminal ZO-1 interacting motif (ZIM) in its head region. The rod domain is involved in dimerization and interaction with the RhoA activator, GEF-H1. Cingulin has also been found to interact with microtubules (MTs) through the N-terminal head region, and these interactions
528-603: Is different from Wikidata All article disambiguation pages All disambiguation pages Cingulin 57530 70737 ENSG00000143375 ENSMUSG00000068876 Q9P2M7 P59242 NM_020770 NM_001037711 NM_001293727 NP_065821 n/a Cingulin (CGN; from the Latin cingere “to form a belt around”) is a cytosolic protein encoded by the CGN gene in humans localized at tight junctions (TJs) of vertebrate epithelial and endothelial cells. Cingulin
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#1732845550488576-440: Is found in invertebrate chordates such as lancelets (a sister subphylum known as the cephalochordates ), though it lacks eyes and other complex special sense organs comparable to those of vertebrates. Other chordates do not show any trends towards cephalization. The rostral end of the neural tube is expanded by a thickening of the walls and expansion of the central canal of spinal cord into three primary brain vesicles :
624-399: Is known about the specific role of cingulin in human diseases. Cingulin expression has been studied in human carcinomas and shown to be expressed in adenocarcinomas and down-regulated in squamous carcinomas. Furthermore, histone deacetylase inhibitors, such as sodium butyrate, strongly upregulate its expression in some cultured cells. Cingulin, as other junctional proteins could be used as
672-448: Is localized in the cell cortex. Through early mouse development, cytocortical cingulin in present from oogenesis (cumulus-oocyte contact sites) until 16-cells morulae stage (apical microvillous zones) during early embryogenesis; then maternal cingulin is degraded by endocytic turn-over from the 32-cells stage. Regarding the zygotic cingulin, it accumulates at the tight junctions from 16-cells stage, 10 hours after ZO-1 assembly. Furthermore,
720-527: Is supported by a cartilaginous or bony gill arch , which develop embryonically from pharyngeal arches . Bony fish have three pairs of gill arches, cartilaginous fish have five to seven pairs, while the primitive jawless fish have seven pairs. The ancestral vertebrates likely had more arches than seven, as some of their chordate relatives have more than 50 pairs of gill opens, although most, if not all, of these openings are actually involved in filter feeding rather than respiration . In jawed vertebrates ,
768-617: The Cephalochordata is the sister taxon to Craniata (Vertebrata). This group, called the Notochordata, was placed as sister group to the Tunicata (Urochordata). Studies since 2006 analyzing large sequencing datasets however strongly support Olfactores (tunicates + vertebrates) as a clade, and hence the placement of Cephalochordata as sister-group to Olfactores (known as the " Olfactores hypothesis "). The following cladogram summarizes
816-548: The Chengjiang biota and lived about 518 million years ago. These include Haikouichthys , Myllokunmingia , Zhongjianichthys , and probably Haikouella . Unlike the other fauna that dominated the Cambrian, these groups had the basic vertebrate body plan: a notochord, rudimentary vertebrae, and a well-defined head and tail. All of these early vertebrates lacked jaws in the common sense and relied on filter feeding close to
864-474: The Izu–Ogasawara Trench at a depth of 8,336 metres (27,349 feet). Many fish varieties are the main predators in most of the world's freshwater and marine water bodies . The rest of the vertebrate species are tetrapods, a single lineage that includes amphibians (with roughly 7,000 species); mammals (with approximately 5,500 species); and reptiles and birds (with about 20,000 species divided evenly between
912-623: The Jurassic . The Cenozoic world saw great diversification of bony fishes, amphibians, reptiles, birds and mammals. Over half of all living vertebrate species (about 32,000 species) are fish (non-tetrapod craniates), a diverse set of lineages that inhabit all the world's aquatic ecosystems, from the Tibetan stone loach ( Triplophysa stolickai ) in western Tibetan hot springs near Longmu Lake at an elevation of 5,200 metres (17,100 feet) to an unknown species of snailfish (genus Pseudoliparis ) in
960-562: The Placodermi and the Acanthodii , both considered paraphyletic . Other ways of classifying the vertebrates have been devised, particularly with emphasis on the phylogeny of early amphibians and reptiles. An example based on Janvier (1981, 1997), Shu et al. (2003), and Benton (2004) is given here († = extinct ): While this traditional classification is orderly, most of the groups are paraphyletic , i.e. do not contain all descendants of
1008-526: The cartilaginous fish and the bony fish . Bony fish include the lobe-finned fish , which gave rise to the tetrapods , the animals with four limbs. Vertebrates make up less than five percent of all described animal species ; the rest are all invertebrates , that lack a backbone. The word 'vertebrate' derives from the Latin vertebratus ("jointed"), from vertebra meaning "joint", in turn from Latin vertere to turn. All vertebrates are built along
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#17328455504881056-565: The genetics of organisms. Phylogenetic classification is based solely on phylogeny . Evolutionary systematics gives an overview; phylogenetic systematics gives detail. The two systems are thus complementary rather than opposed. Conventional classification has extant vertebrates grouped into seven classes based on traditional interpretations of gross anatomical and physiological traits. The commonly held classification lists three classes of fish and four of tetrapods . In addition to these, there are two classes of extinct armoured fishes,
1104-405: The larvae of lampreys , has evolved into the thyroid in most vertebrates. Vertebrates vary in body length ranging from the frog species Brachycephalus pulex , a Brazilian flea toad, with a minimum adult snout–vent length of 6.45 millimetres (0.254 in) to the blue whale , at up to 33 m (108 ft). With only one exception, the defining characteristics of a vertebrate are
1152-410: The prosencephalon ( forebrain ), mesencephalon ( midbrain ) and rhombencephalon ( hindbrain ), which are further differentiated in the various vertebrate groups. Two laterally placed retinas and optical nerves form around outgrowths from the midbrain, except in hagfish which may have secondarily lost the structures. The forebrain is more well-developed in most tetrapods and subdivided into
1200-418: The spinal cord . The other feature unique to vertebrates is the presence of a cranium , or skull. The vertebrates make up the subphylum Vertebrata with some 65,000 species in the phylum Chordata . The vertebrates include mammals , birds , amphibians , and various classes of reptiles and fish . Classes of fish include the jawless Agnatha , and the jawed Gnathostomata . The jawed fish include both
1248-432: The telencephalon and diencephalon , while the midbrain dominates in fish and some salamanders . In vertebrates with paired appendages, especially tetrapods, a pair of secondary enlargements of the hindbrain become the cerebella , which modulate complex motor coordinations . The brain vesicles are usually bilaterally symmetrical , giving rise to the paired cerebral hemispheres in mammals . The resultant anatomy of
1296-399: The vertebral column , and the skull . The embryonic notochord is replaced by a segmented series of irregular bones known as vertebrae . The vertebrae are separated by intervertebral discs of fibrocartilage , which are remnants of the notochord. Hagfish are the only extant vertebrate whose notochord persists and is not integrated or replaced by the vertebral column. In the sturgeon
1344-403: The absence of cingulin. Together with paracingulin, cingulin also was reported to regulate claudin-2 expression through RhoA-dependent and independent mechanisms. The role of cingulin in development has been studied by morpholino . oligonucleotide-mediated depletion in chicken, indicating that cingulin is involved in neural crest development. In early mouse and frog embryos, maternal cingulin
1392-462: The axial endoskeleton, enclosed by neural arches , with a fore-end enlargement within a skeletonized braincase . This provides an alternative name for vertebrates, the craniates . All vertebrate embryos develop transient pharyngeal arches ; in fish, these develop into the branchial arches that support the gills . An organ in the pharynx , the endostyle , which assists in filter feeding in adult cephalochordates and urochordates , and in
1440-531: The basic chordate body plan of five shared characteristics . These are a rigid axial skeleton that includes a vertebral column developed around an elastic or flexible notochord , and a skull. The notochord stretches out for almost the whole length of the body of a chordate , it lies dorsal to the gastrointestinal tract and provides flexible support to the body. The notochord remains in the jawless fish and cephalochordates (non-vertebrate chordates). In vertebrates it becomes replaced either wholly or in part by
1488-427: The brain (which itself is a fused cluster of segmental ganglia from the rostral metameres ). Molecular markers known as conserved signature indels (CSIs) in protein sequences have been identified and provide distinguishing criteria for the vertebrate subphylum. Specifically, 5 CSIs in the following proteins: protein synthesis elongation factor-2 , eukaryotic translation initiation factor 3 , adenosine kinase and
CGN - Misplaced Pages Continue
1536-409: The class's common ancestor. For instance, descendants of the first reptiles include modern reptiles, mammals and birds; the agnathans have given rise to the jawed vertebrates ; the bony fishes have given rise to the land vertebrates ; the traditional " amphibians " have given rise to the reptiles (traditionally including the synapsids or mammal-like "reptiles"), which in turn have given rise to
1584-551: The demise of virtually all jawless fishes save for lampreys and hagfishes, as well as the Placodermi , a group of armoured fish that dominated the entirety of that period since the late Silurian as well as the eurypterids , dominant animals of the preceding Silurian , and the anomalocarids . By the middle of the Devonian, several droughts, anoxic events and oceanic competition led a lineage of sarcopterygii to leave water, eventually establishing themselves as terrestrial tetrapods in
1632-408: The dorsal nerve cord and migrate together with the mesodermal somites to innervate the various different structures that develop in the body. The vertebrates are the only chordate group with neural cephalization , and their neural functions are centralized towards a series of enlarged clusters in the head , which give rise to a brain . A slight swelling of the anterior end of the nerve cord
1680-403: The endoskeleton is of cartilage and the vertebral column consists of mostly vertebrae of cartilage, without vertebral centrums , supported by the retained notochord. Most vertebrates are aquatic and carry out gas exchange via gills . The gills are carried right behind the head, bordering the posterior margins of a series of crescentic openings from the pharynx to the outside. Each gill
1728-483: The first gill arch pair evolved into the jointed jaws and form an additional oral cavity ahead of the pharynx . Research also suggests that the sixth branchial arch contributed to the formation of the vertebrate shoulder, which separated the head as a distinct part of the body. In amphibians and some primitive bony fishes, the larvae bear external gills , branching off from the gill arches. These are reduced in adulthood, their respiratory function taken over by
1776-421: The gill arches form during fetal development , and form the basis of essential structures such as jaws , the thyroid gland , the larynx , the columella (corresponding to the stapes in mammals ) and, in mammals, the malleus and incus . The central nervous system of vertebrates is based on the embryonic dorsal nerve cord (which then flattens into a neural plate before folding and fusing over into
1824-400: The gut tube, with a split brain stem circumventing the foregut around each side to form a brain on the dorsal side of the mouth . The higher functions of the vertebrate CNS are highly centralized towards the brain (particularly the forebrain), while the invertebrate CNS is significantly more decentralized with the segmental ganglia having substantial neural autonomy independent of
1872-443: The internal gills proper in fishes and by cutaneous respiration in most amphibians. While some amphibians such as axolotl retain the external gills into adulthood, the complex internal gill system as seen in fish apparently being irrevocably lost very early in the evolution of tetrapods , who evolved lungs (which are homologous to swim bladders ) to breathe air. While the more specialized terrestrial vertebrates lack gills,
1920-460: The mammals and birds. Most scientists working with vertebrates use a classification based purely on phylogeny , organized by their known evolutionary history and sometimes disregarding the conventional interpretations of their anatomy and physiology. In phylogenetics , the relationships between animals are illustrated as a hierarchy known as a phylogenetic tree . The cladogram below is based on studies compiled by Philippe Janvier and others for
1968-591: The relationships between the Olfactores (vertebrates and tunicates) and the Cephalochordata. Amphioxiformes (lancelets) [REDACTED] Tunicata /Urochordata ( sea squirts , salps , larvaceans ) [REDACTED] Vertebrata [REDACTED] Vertebrates originated during the Cambrian explosion , which saw a rise in organism diversity. The earliest known vertebrates belongs to
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2016-644: The seabed. A vertebrate group of uncertain phylogeny, small eel-like conodonts , are known from microfossils of their paired tooth segments from the late Cambrian to the end of the Triassic. The first jawed vertebrates may have appeared in the late Ordovician (~445 mya) and became common in the Devonian period , often known as the "Age of Fishes". The two groups of bony fishes , the Actinopterygii and Sarcopterygii , evolved and became common. The Devonian also saw
2064-633: The succeeding Carboniferous . Amniotes branched from amphibious tetrapods early in the Carboniferous period. The synapsid amniotes were dominant during the late Paleozoic, the Permian , while diapsid amniotes became dominant during the Mesozoic . In the sea, the teleosts and sharks became dominant. Mesothermic synapsids called cynodonts gave rise to endothermic mammals and diapsids called dinosaurs eventually gave rise to endothermic birds , both in
2112-554: The synthesis of cingulin in early mouse embryos is tissue-specific and it occurs in blastocyst (up-regulated in trophectoderm and down-regulated in inner-cells). In Xenopus laevis embryos, maternal cingulin is recruited to apical cell-cell junctions from 2-cells stage. In 2004, a protein homologous to cingulin was discovered and named JACOP (also known as paracingulin, or cingulin-like 1 protein; CGNL1 ). Although cingulin has been involved in regulation of RhoA signaling and gene expression in cultured cells and KO mice, nothing
2160-402: The two classes). Tetrapods comprise the dominant megafauna of most terrestrial environments and also include many partially or fully aquatic groups (e.g., sea snakes , penguins , cetaceans). There are several ways of classifying animals. Evolutionary systematics relies on anatomy , physiology and evolutionary history, which is determined through similarities in anatomy and, if possible,
2208-414: The vertebral column. The vertebral column typically continues beyond the rear orifice ( anus , or cloaca ) to form an elongated tail . Some vertebrates evolved to become tailless with only a vestigial coccyx . A dorsal nerve cord , which folds and fuses into a hollow neural tube during embryonic development and eventually gives rise to the brain and spinal cord , runs more dorsally to
2256-477: Was originally discovered at the MRC Laboratory of Molecular Biology (Cambridge, UK) by Dr. Sandra Citi, as a protein present in chicken intestinal epithelial cells, that co-purified with non-muscle myosin II and was specifically localized at tight junctions ( zonulae occludentes ). Cingulin is a homodimer, each subunit containing a N-terminal globular "head" domain, a long α-helical coiled-coil "rod" domain and
2304-410: Was regulated by phosphorylation by the adenosine monophosphate-activated protein kinase (AMPK). The function of cingulin has been studied by knockout (KO), knockdown (KD) and over-expression approaches. Embryoid bodies derived from embryonic stem cells where one or both cingulin alleles were targeted by homologous recombination show apparently normal tight junctions, but changes in the expression of
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