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99-561: Beverly Hills Cop is a 1984 American buddy cop action comedy film directed by Martin Brest , with a screenplay by Daniel Petrie Jr. , and story by Danilo Bach and Daniel Petrie Jr. It stars Eddie Murphy as Axel Foley , a street-smart Detroit detective who visits Beverly Hills, California , to solve the murder of his best friend. Judge Reinhold , John Ashton , Ronny Cox , Lisa Eilbacher , Steven Berkoff , Paul Reiser , and Jonathan Banks appear in supporting roles. This first film in

198-413: A fast heart rate , sweating, and dilated pupils . High doses can result in high blood pressure or high body temperature . Onset of effects can begin within seconds to minutes of use, depending on method of delivery, and can last between five and ninety minutes. As cocaine also has numbing and blood vessel constriction properties, it is occasionally used during surgery on the throat or inside of

297-540: A withdrawal state with emotional-motivational deficits upon cessation of cocaine use. Crack baby is a term for a child born to a mother who used crack cocaine during her pregnancy. The threat that cocaine use during pregnancy poses to the fetus is now considered exaggerated. Studies show that prenatal cocaine exposure (independent of other effects such as, for example, alcohol, tobacco, or physical environment) has no appreciable effect on childhood growth and development. In 2007, he National Institute on Drug Abuse of

396-426: A bridge between the use of different groups of drugs. It is legal for people to use coca leaves in some Andean nations, such as Peru and Bolivia, where they are chewed, consumed in the form of tea, or are sometimes incorporated into food products. Coca leaves are typically mixed with an alkaline substance (such as lime ) and chewed into a wad that is retained in the buccal pouch (mouth between gum and cheek, much

495-471: A car theft the pair had committed in their youth, but has since landed a job as a security guard in Beverly Hills thanks to mutual friend Jenny Summers. Mikey shows Axel some German bearer bonds and Axel wonders how he got them, but chooses not to question him about it. After going out to a bar, they return to Axel's apartment, where two men, Zack and Casey, knock Axel unconscious, confront Mikey about

594-517: A flat, hard surface (such as a mobile phone screen, mirror, CD case or book) and divided into "bumps", "lines" or "rails", and then insufflated. A 2001 study reported that the sharing of straws used to "snort" cocaine can spread blood diseases such as hepatitis C . Subjective effects not commonly shared with other methods of administration include a ringing in the ears moments after injection (usually when over 120 milligrams) lasting 2 to 5 minutes including tinnitus and audio distortion. This

693-411: A greater likelihood of relapse when the drug is withheld. ΔFosB increases the expression of AMPA receptor subunit GluR2 and also decreases expression of dynorphin , thereby enhancing sensitivity to reward. DNA damage is increased in the brain of rodents by administration of cocaine. During DNA repair of such damages, persistent chromatin alterations may occur such as methylation of DNA or

792-480: A hypothesis that cocaine may also function as a so-called "DAT inverse agonist" or "negative allosteric modifier of DAT" resulting in dopamine transporter reversal , and subsequent dopamine release into the synaptic cleft from the axon terminal in a manner similar to but distinct from amphetamines . Sigma receptors are affected by cocaine, as cocaine functions as a sigma ligand agonist. Further specific receptors it has been demonstrated to function on are NMDA and

891-431: A joint or blunt . Acute exposure to cocaine has many effects on humans, including euphoria, increases in heart rate and blood pressure, and increases in cortisol secretion from the adrenal gland. In humans with acute exposure followed by continuous exposure to cocaine at a constant blood concentration, the acute tolerance to the chronotropic cardiac effects of cocaine begins after about 10 minutes, while acute tolerance to

990-477: A long period of time who do not hydrate sufficiently may experience demineralization of their teeth due to the pH of the tooth surface dropping too low (below 5.5). Cocaine use also promotes the formation of blood clots . This increase in blood clot formation is attributed to cocaine-associated increases in the activity of plasminogen activator inhibitor , and an increase in the number, activation, and aggregation of platelets . Chronic intranasal usage can degrade

1089-473: A marked elevation of blood pressure, which can be life-threatening, abnormal heart rhythms , and death. Anxiety, paranoia , and restlessness can also occur, especially during the comedown. With excessive dosage, tremors, convulsions and increased body temperature are observed. Severe cardiac adverse events, particularly sudden cardiac death , become a serious risk at high doses due to cocaine's blocking effect on cardiac sodium channels. Incidental exposure of

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1188-508: A one-time license deal with an option for a sequel to Netflix to create the fourth film . In April 2022, Mark Molloy was announced as the film's director, while Will Beall penned the script. The official teaser trailer for the fourth film was released on December 14, 2023. The film was released in July 2024. Buddy cop Frequently, although not always, the two heroes are of different ethnicity or cultures. However, regardless of ethnicity,

1287-489: A pipe made from a small glass tube, often taken from " love roses ", small glass tubes with a paper rose that are promoted as romantic gifts. These are sometimes called "stems", "horns", "blasters" and "straight shooters". A small piece of clean heavy copper or occasionally stainless steel scouring pad – often called a "brillo" (actual Brillo Pads contain soap, and are not used) or "chore" (named for Chore Boy brand copper scouring pads) – serves as

1386-548: A precursor to the buddy cop film genre. Other early pioneers of the buddy cop film genre are the 1967 American film In the Heat of the Night and 1974's Freebie and the Bean . The genre was later popularized by the 1982 film 48 Hrs. , starring Eddie Murphy and Nick Nolte , then also the 1984 film Beverly Hills Cop along with its 1987 sequel Beverly Hills Cop II , all three are among

1485-438: A reduction base and flow modulator in which the "rock" can be melted and boiled to vapor. Crack is smoked by placing it at the end of the pipe; a flame held close to it produces vapor, which is then inhaled by the smoker. The effects felt almost immediately after smoking, are very intense and do not last long — usually 2 to 10 minutes. When smoked, cocaine is sometimes combined with other drugs, such as cannabis , often rolled into

1584-414: A scuffle with Zack at Maitland's country club , Axel attempts to alert Bogomil that Maitland must be a smuggler, but Beverly Hills Police Chief Hubbard, who has learned of Axel's ill-advised investigative actions, orders that he be escorted out of town. Axel convinces Billy to pick up Jenny instead and take her with them to the warehouse, where a shipment is due to arrive that day. Axel and Jenny break into

1683-437: A stroke, irreversible brain damage, or a heart attack. Persons with regular or problematic use of cocaine have a significantly higher rate of death, and are specifically at higher risk of traumatic deaths and deaths attributable to infectious disease. The extent of absorption of cocaine into the systemic circulation after nasal insufflation is similar to that after oral ingestion. The rate of absorption after nasal insufflation

1782-418: Is a central nervous system stimulant. Its effects can last from 15 minutes to an hour. The duration of cocaine's effects depends on the amount taken and the route of administration. Cocaine can be in the form of fine white powder and has a bitter taste. Crack cocaine is a smokeable form of cocaine made into small "rocks" by processing cocaine with sodium bicarbonate (baking soda) and water. Crack cocaine

1881-412: Is also systemic, relating to disputes between crack dealers and users. Acute exposure may induce cardiac arrhythmias, including atrial fibrillation , supraventricular tachycardia , ventricular tachycardia , and ventricular fibrillation . Acute exposure may also lead to angina , heart attack , and congestive heart failure . Cocaine overdose may cause seizures , abnormally high body temperature and

1980-452: Is also used in medicine by Indigenous South Americans for various purposes and rarely, but more formally, as a local anaesthetic or diagnostic tool by medical practitioners in more developed countries. It is primarily obtained from the leaves of two Coca species native to South America: Erythroxylum coca and E. novogranatense . After extraction from the plant, and further processing into cocaine hydrochloride (powdered cocaine),

2079-400: Is colloquially referred to as a "bell ringer". In a study of cocaine users, the average time taken to reach peak subjective effects was 3.1 minutes. The euphoria passes quickly. Aside from the toxic effects of cocaine, there is also the danger of circulatory emboli from the insoluble substances that may be used to cut the drug. As with all injected illicit substances , there is a risk of

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2178-470: Is limited by cocaine-induced vasoconstriction of capillaries in the nasal mucosa. Onset of absorption after oral ingestion is delayed because cocaine is a weak base with a pKa of 8.6, and is thus in an ionized form that is poorly absorbed from the acidic stomach and easily absorbed from the alkaline duodenum. The rate and extent of absorption from inhalation of cocaine is similar or greater than with intravenous injection, as inhalation provides access directly to

2277-425: Is not what is involved in the habituation of the substance so much as the conformation and binding properties to where and how on the transporter the molecule binds. Conflicting findings have challenged the widely accepted view that cocaine functions solely as a reuptake inhibitor. To induce euphoria an intravenous dose of 0.3-0.6 mg/kg of cocaine is required, which blocks 66-70% of dopamine transporters (DAT) in

2376-417: Is possible in regular users until after the sections of hair grown during the period of cocaine use are cut or fall out. The pharmacodynamics of cocaine involve the complex relationships of neurotransmitters (inhibiting monoamine uptake in rats with ratios of about: serotonin :dopamine = 2:3, serotonin: norepinephrine = 2:5). The most extensively studied effect of cocaine on the central nervous system

2475-521: Is referred to as "crack" because of the crackling sounds it makes when heated. Cocaine use leads to increases in alertness, feelings of well-being and euphoria , increased energy and motor activity, and increased feelings of competence and sexuality. Analysis of the correlation between the use of 18 various psychoactive substances shows that cocaine use correlates with other " party drugs " (such as ecstasy or amphetamines ), as well as with heroin and benzodiazepines use, and can be considered as

2574-434: Is that the smoking of cocaine chemically breaks down tooth enamel and causes tooth decay . Cocaine can cause involuntary tooth grinding, known as bruxism , which can deteriorate tooth enamel and lead to gingivitis . Additionally, stimulants like cocaine, methamphetamine, and even caffeine cause dehydration and dry mouth . Since saliva is an important mechanism in maintaining one's oral pH level, people who use cocaine over

2673-404: Is the blockade of the dopamine transporter protein. Dopamine neurotransmitter released during neural signaling is normally recycled via the transporter; i.e., the transporter binds the transmitter and pumps it out of the synaptic cleft back into the presynaptic neuron , where it is taken up into storage vesicles . Cocaine binds tightly at the dopamine transporter forming a complex that blocks

2772-416: Is thrown out of a window by Maitland's bodyguards and arrested for trespassing. At the local police station, Beverly Hills Police Department Lieutenant Andrew Bogomil assigns Sergeant John Taggart and Detective Billy Rosewood to follow Axel. They have a humiliating and comical encounter with him when he temporarily disables their car. As a result, Rosewood and Taggart do not get along with Axel at first, but

2871-647: The Beverly Hills Cop franchise shot Murphy to international stardom, won the People's Choice Award for "Favorite Motion Picture", and was nominated for both the Golden Globe Award for Best Motion Picture – Musical or Comedy and Academy Award for Best Original Screenplay in 1985. An immediate blockbuster , it received positive reviews and earned $ 234 million at the North American domestic box office, making it

2970-406: The 5-HT 3 receptor , which is a ligand-gated ion channel . An overabundance of 5-HT 3 receptors is reported in cocaine-conditioned rats, though 5-HT 3 's role is unclear. The 5-HT 2 receptor (particularly the subtypes 5-HT 2A , 5-HT 2B and 5-HT 2C ) are involved in the locomotor-activating effects of cocaine. Cocaine has been demonstrated to bind as to directly stabilize

3069-445: The DAT transporter on the open outward-facing conformation. Further, cocaine binds in such a way as to inhibit a hydrogen bond innate to DAT. Cocaine's binding properties are such that it attaches so this hydrogen bond will not form and is blocked from formation due to the tightly locked orientation of the cocaine molecule. Research studies have suggested that the affinity for the transporter

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3168-731: The Pointer Sisters . The soundtrack also had two Patti LaBelle hits, " New Attitude ," which hit the top twenty on the US, and the Grammy Award-winning " Stir It Up ." Beverly Hills Cop was released on December 5, 1984, in 1,532 theaters. It debuted in first place at the US box office, making $ 15,214,805 in its first five days of release. It expanded on December 21 into 2,006 theatres. The film stayed at number one for 13 consecutive weeks and returned to number one in its 15th weekend making 14 non-consecutive weeks at number one tying Tootsie for

3267-631: The Single Convention on Narcotic Drugs has required countries to make recreational use of cocaine a crime . In the United States, cocaine is regulated as a Schedule II drug under the Controlled Substances Act , meaning that it has a high potential for abuse but has an accepted medical use. While rarely used medically today, its accepted uses are as a topical local anesthetic for the upper respiratory tract as well as to reduce bleeding in

3366-534: The cartilage separating the nostrils (the septum nasi ), leading eventually to its complete disappearance. Due to the absorption of the cocaine from cocaine hydrochloride, the remaining hydrochloride forms a dilute hydrochloric acid. Illicitly-sold cocaine may be contaminated with levamisole. Levamisole may accentuate cocaine's effects. Levamisole-adulterated cocaine has been associated with autoimmune disease. Cocaine use leads to an increased risk of hemorrhagic and ischemic strokes . Cocaine use also increases

3465-604: The liver to form cocaethylene . Studies have suggested cocaethylene is more euphoric , and has a higher cardiovascular toxicity than cocaine by itself. Depending on liver and kidney functions, cocaine metabolites are detectable in urine between three and eight days. Generally speaking benzoylecgonine is eliminated from someone's urine between three and five days. In urine from heavy cocaine users, benzoylecgonine can be detected within four hours after intake and in concentrations greater than 150 ng/mL for up to eight days later. Detection of cocaine metabolites in hair

3564-547: The mouth against the inner cheek ; it has traditionally been used to combat the effects of cold, hunger, and altitude sickness . Cocaine was first isolated from the leaves in 1860. Globally, in 2019, cocaine was used by an estimated 20 million people (0.4% of adults aged 15 to 64 years). The highest prevalence of cocaine use was in Australia and New Zealand (2.1%), followed by North America (2.1%), Western and Central Europe (1.4%), and South and Central America (1.0%). Since 1961,

3663-616: The Andes to prevent altitude sickness . Its actual effectiveness has never been systematically studied. In 1986 an article in the Journal of the American Medical Association revealed that U.S. health food stores were selling dried coca leaves to be prepared as an infusion as "Health Inca Tea". While the packaging claimed it had been "decocainized", no such process had actually taken place. The article stated that drinking two cups of

3762-443: The D 1 dopamine receptor. Cocaine also blocks sodium channels , thereby interfering with the propagation of action potentials ; thus, like lignocaine and novocaine , it acts as a local anesthetic. It also functions on the binding sites to the dopamine and serotonin sodium dependent transport area as targets as separate mechanisms from its reuptake of those transporters; unique to its local anesthetic value which makes it in

3861-547: The Global Burden of Disease study found that cocaine use caused around 7,300 deaths annually. Coca leaves have been used by Andean civilizations since ancient times . In ancient Wari culture , Inca culture, and through modern successor indigenous cultures of the Andes mountains , coca leaves are chewed, taken orally in the form of a tea , or alternatively, prepared in a sachet wrapped around alkaline burnt ashes, and held in

3960-532: The Museum of Modern Art. The film shipped a record 1.3 million videos in the United States on its initial release. American Film Institute Lists The film spawned a film series with three sequels, Beverly Hills Cop II , Beverly Hills Cop III and Beverly Hills Cop: Axel F , all starring Eddie Murphy. Judge Reinhold reprised his role for the sequels. John Ashton returned for the second and fourth film, but not third. The second film met with mixed reviews but

4059-638: The United States in December 2017, and is indicated for the introduction of local anesthesia of the mucous membranes for diagnostic procedures and surgeries on or through the nasal cavities of adults. Cocaine hydrochloride ( Numbrino ) was approved for medical use in the United States in January 2020. The most common adverse reactions in people treated with Goprelto are headache and epistaxis . The most common adverse reactions in people treated with Numbrino are hypertension, tachycardia, and sinus tachycardia. Cocaine

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4158-419: The United States warned about health risks while cautioning against stereotyping: Many recall that "crack babies", or babies born to mothers who used crack cocaine while pregnant, were at one time written off by many as a lost generation. They were predicted to suffer from severe, irreversible damage, including reduced intelligence and social skills. It was later found that this was a gross exaggeration. However,

4257-455: The acetylation or methylation of histones at the sites of repair. These alterations can be epigenetic scars in the chromatin that contribute to the persistent epigenetic changes found in cocaine addiction . In humans, cocaine abuse may cause structural changes in brain connectivity, though it is unclear to what extent these changes are permanent. Cocaine dependence develops after even brief periods of regular cocaine use and produces

4356-674: The baby to grow poorly. As a result, cocaine-exposed babies are more likely than unexposed babies to be born with low birth weight (less than 5.5 lb or 2.5 kg). Low-birthweight babies are 20 times more likely to die in their first month of life than normal-weight babies, and face an increased risk of lifelong disabilities such as mental retardation and cerebral palsy. Cocaine-exposed babies also tend to have smaller heads, which generally reflect smaller brains. Some studies suggest that cocaine-exposed babies are at increased risk of birth defects, including urinary tract defects and, possibly, heart defects. Cocaine also may cause an unborn baby to have

4455-449: The brain. Re-administering cocaine beyond this threshold does not significantly increase DAT occupancy but still results in an increase of euphoria which cannot be explained by reuptake inhibition alone. This discrepancy is not shared with other dopamine reuptake inhbitors like bupropion , sibutramine , mazindol or tesofensine , which have similar or higher potencies than cocaine as dopamine reuptake inhibitors. These findings have evoked

4554-625: The breakdown of the blood–brain barrier. Physical side effects from chronic smoking of cocaine include coughing up blood , bronchospasm , itching , fever , diffuse alveolar infiltrates without effusions, pulmonary and systemic eosinophilia , chest pain, lung trauma, sore throat, asthma , hoarse voice, dyspnea (shortness of breath), and an aching, flu -like syndrome. Cocaine constricts blood vessels , dilates pupils , and increases body temperature, heart rate, and blood pressure. It can also cause headaches and gastrointestinal complications such as abdominal pain and nausea. A common but untrue belief

4653-402: The central difference is normally that one is "wilder" than the other: a hot-tempered iconoclast is paired with a more even-tempered partner. Often the "wilder" partner is the younger of the two, with the even-tempered partner having more patience and experience. These films sometimes also contain a variation on the good cop/bad cop motif , in which one partner is kinder and law-abiding, while

4752-581: The city of Beverly Hills prohibited filming after 10:30 p.m. The soundtrack was released on MCA Records and won the Grammy Award for Best Score Soundtrack for Visual Media (1986). It featured three top 10 singles on the Billboard Hot 100 , the instrumental title tune, " Axel F ", composed and performed by Harold Faltermeyer , the Glenn Frey song " The Heat Is On ", and " Neutron Dance ," performed by

4851-514: The drug is administered by being either snorted , applied topically to the mouth , or dissolved and injected into a vein . It can also then be turned into free base form (typically crack cocaine ), in which it can be heated until sublimated and then the vapours can be inhaled . Cocaine stimulates the mesolimbic pathway in the brain. Mental effects may include an intense feeling of happiness , sexual arousal , loss of contact with reality , or agitation . Physical effects may include

4950-764: The euphoric effects of cocaine begins after about one hour. With excessive or prolonged use, the drug can cause itching , fast heart rate , and paranoid delusions or sensations of insects crawling on the skin . Intranasal cocaine and crack use are both associated with pharmacological violence. Aggressive behavior may be displayed by both addicts and casual users. Cocaine can induce psychosis characterized by paranoia, impaired reality testing , hallucinations , irritability, and physical aggression. Cocaine intoxication can cause hyperawareness, hypervigilance , and psychomotor agitation and delirium . Consumption of large doses of cocaine can cause violent outbursts, especially by those with preexisting psychosis. Crack-related violence

5049-411: The extreme of one officer being partnered with a cartoon cat. A subgenre of the buddy cop film is the buddy cop-dog movie , which teams a cop with a dog , but uses the same element of unlikely partnership to create comedic hijinks, such as Turner & Hooch , Top Dog and K-9 . Akira Kurosawa 's 1949 Japanese film Stray Dog , starring Toshiro Mifune and Takashi Shimura , is considered

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5148-512: The eye to sublimated cocaine while smoking crack cocaine can cause serious injury to the cornea and long-term loss of visual acuity. Although it has been commonly asserted, the available evidence does not show that chronic use of cocaine is associated with broad cognitive deficits. Research is inconclusive on age-related loss of striatal dopamine transporter (DAT) sites, suggesting cocaine has neuroprotective or neurodegenerative properties for dopamine neurons. Exposure to cocaine may lead to

5247-504: The fact that most of these children appear normal should not be over-interpreted as indicating that there is no cause for concern. Using sophisticated technologies, scientists are now finding that exposure to cocaine during fetal development may lead to subtle, yet significant, later deficits in some children, including deficits in some aspects of cognitive performance, information-processing, and attention to tasks—abilities that are important for success in school. There are also warnings about

5346-413: The film with the most weeks at number one. The film earned $ 234,760,478 in the United States, being the highest-grossing film released in 1984. Adjusted for inflation, it is the third highest-grossing R-rated film of all-time behind The Exorcist and The Godfather . For nearly two decades, Beverly Hills Cop held the record for having the highest domestic gross for an R-rated film until 2003, when it

5445-435: The film's producers, Simpson and Bruckheimer, convinced Eddie Murphy to replace Stallone in the film, prompting more rewrites. Besides Stallone and Rourke, other actors who were considered for the role of Axel Foley included Richard Pryor , Al Pacino , and James Caan . Harrison Ford was offered the role of Axel Foley but turned it down. The final shooting draft of the script, which was extensively revised with Murphy's input,

5544-716: The highest-grossing film released in the U.S. in 1984. Adjusted for inflation, it is the highest-grossing R-rated film in the U.S. since 1977, with a total box office gross of $ 730,714,743 in 2024. Axel Foley is a plainclothes Detroit police detective whose latest unauthorized sting operation goes sour when two uniformed officers intervene, resulting in a high-speed chase through the city that causes widespread damage. Axel's superior, Inspector Douglas Todd, reprimands him for his reckless behavior and threatens to fire him unless he changes his ways. Axel arrives at his apartment to find it has been broken into by his childhood friend, Michael "Mikey" Tandino. Mikey had done prison time for

5643-436: The mechanisms of cocaine addiction. The onset of cocaine's euphoric effects is fastest with inhalation, beginning after 3–5 seconds. This gives the briefest euphoria (5–15 minutes). Cocaine is smoked by inhaling the vapor produced when crack cocaine is heated to the point of sublimation. In a 2000 Brookhaven National Laboratory medical department study, based on self-reports of 32 people who used cocaine who participated in

5742-411: The mismatched-partners (if not always specifically cops) theme. Cocaine Cocaine (from French cocaïne , from Spanish coca , ultimately from Quechua kúka ) is a tropane alkaloid that acts as a central nervous system (CNS) stimulant . As an extract, it is mainly used recreationally and often illegally for its euphoric and rewarding effects. It

5841-447: The most successful buddy cop films. The genre was further popularized by the 1986 film Running Scared starring Gregory Hines and Billy Crystal and the 1987 film Lethal Weapon starring Mel Gibson and Danny Glover . The genre was revisited multiple times by Lethal Weapon creator Shane Black , who went on to write The Last Boy Scout , Last Action Hero , Kiss Kiss Bang Bang , and The Nice Guys , all of which play off

5940-399: The mouth, throat and nasal cavities. Cocaine eye drops are frequently used by neurologists when examining patients suspected of having Horner syndrome . In Horner syndrome, sympathetic innervation to the eye is blocked. In a healthy eye, cocaine will stimulate the sympathetic nerves by inhibiting norepinephrine reuptake, and the pupil will dilate; if the patient has Horner syndrome,

6039-404: The nose to control pain, bleeding, and vocal cord spasm . Cocaine crosses the blood–brain barrier via a proton-coupled organic cation antiporter and (to a lesser extent) via passive diffusion across cell membranes . Cocaine blocks the dopamine transporter , inhibiting reuptake of dopamine from the synaptic cleft into the pre-synaptic axon terminal ; the higher dopamine levels in

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6138-414: The nose by about five minutes. This occurs because cocaine's absorption is slowed by its constricting effect on the blood vessels of the nose. Insufflation of cocaine also leads to the longest duration of its effects (60–90 minutes). When insufflating cocaine, absorption through the nasal membranes is approximately 30–60% In a study of cocaine users, the average time taken to reach peak subjective effects

6237-492: The number of dendritic branches and spines present on neurons involved with the nucleus accumbens and prefrontal cortex areas of the brain. This change can be identified rather quickly, and may be sustained weeks after the last dose of the drug. Transgenic mice exhibiting inducible expression of ΔFosB primarily in the nucleus accumbens and dorsal striatum exhibit sensitized behavioural responses to cocaine. They self-administer cocaine at lower doses than control, but have

6336-441: The opening scene from Saving Private Ryan on the beaches of Normandy. Believe it or not, the finale was me in a stolen Lamborghini playing chicken with an oncoming freight train being driven by the ultra-slimy bad guy." Producer Don Simpson let it be known they didn't want to move forward with Stallone's revisions; since Stallone wasn't willing to negotiate the rewrite, Simpson asked writer Charles "Chip" Proser if he could return

6435-459: The other is a streetwise, "old school" police officer who tends to break (or at least bend) the rules. Another frequent plot device of this genre is placing one of the partners in an unfamiliar setting (like a different city or foreign country) or role (like requiring police field work of a non-cop, rookie, or office-bound "desk jockey"). In these cases, they are usually guided by the other partner. In his review of Rush Hour , Roger Ebert coined

6534-499: The overall risk of death, and intravenous use potentially increases the risk of trauma and infectious diseases such as blood infections and HIV through the use of shared paraphernalia . It also increases risk of stroke , heart attack , cardiac arrhythmia, lung injury (when smoked), and sudden cardiac death . Illicitly sold cocaine can be adulterated with fentanyl , local anesthetics , levamisole , cornstarch, quinine , or sugar, which can result in additional toxicity. In 2017,

6633-516: The peak effects are attained. Cocaine crosses the blood–brain barrier via both a proton-coupled organic cation antiporter and (to a lesser extent) via passive diffusion across cell membranes . As of September 2022, the gene or genes encoding the human proton-organic cation antiporter had not been identified. Cocaine has a short elimination half life of 0.7–1.5 hours and is extensively metabolized by plasma esterases and also by liver cholinesterases , with only about 1% excreted unchanged in

6732-523: The possibility of setting up shop as a private investigator in Beverly Hills, Bogomil nervously agrees to wipe the slate clean for him. Later, Taggart and Billy meet Axel as he is checking out of his hotel and pay his bill. He invites them to join him for a farewell drink, and they accept the offer. In 1977, Paramount executive Don Simpson came up with a movie idea about a cop from East L.A. who transferred to Beverly Hills. Screenwriter Danilo Bach

6831-584: The post-synaptic neuron, contributing to the mental and physical effects of cocaine exposure. A single dose of cocaine induces tolerance to the drug's effects. Repeated use is likely to result in addiction . Addicts who abstain from cocaine may experience prolonged craving lasting for many months. Abstaining addicts also experience modest drug withdrawal symptoms lasting up to 24 hours, with sleep disruption, anxiety, irritability, crashing, depression , decreased libido , decreased ability to feel pleasure , and fatigue being common. Use of cocaine increases

6930-418: The previous drafts written for Stallone, the character of Billy Rosewood was called "Siddons" and was killed off half-way through the script during one of the action scenes. Stallone had renamed the lead character to Axel Cobretti, with the character of Michael Tandino being his brother and Jenny Summers playing his love interest. Stallone has said that his script for Beverly Hills Cop would have "looked like

7029-481: The project back on track: He and Stallone had a mutual interest in "youth treatments" and Simpson knew of a Swiss doctor who was experimenting with injections of a sheep hormone that increased tumescence . Simpson managed to get Stallone's name "put at the top of the list," Simpson boasted to a friend, for an appointment with the very exclusive doctor. Stallone flew to Switzerland , and Simpson promptly continued working on Beverly Hills Cop without him. Two days later,

7128-578: The pulmonary capillary bed. The delay in absorption after oral ingestion may account for the popular belief that cocaine bioavailability from the stomach is lower than after insufflation. Compared with ingestion, the faster absorption of insufflated cocaine results in quicker attainment of maximum drug effects. Snorting cocaine produces maximum physiological effects within 40 minutes and maximum psychotropic effects within 20 minutes. Physiological and psychotropic effects from nasally insufflated cocaine are sustained for approximately 40–60 minutes after

7227-598: The risk of having a heart attack . Relatives of persons with cocaine addiction have an increased risk of cocaine addiction. Cocaine addiction occurs through ΔFosB overexpression in the nucleus accumbens , which results in altered transcriptional regulation in neurons within the nucleus accumbens . ΔFosB levels have been found to increase upon the use of cocaine. Each subsequent dose of cocaine continues to increase ΔFosB levels with no ceiling of tolerance. Elevated levels of ΔFosB leads to increases in brain-derived neurotrophic factor ( BDNF ) levels, which in turn increases

7326-401: The same as chewing tobacco is chewed) and sucked of its juices. The juices are absorbed slowly by the mucous membrane of the inner cheek and by the gastrointestinal tract when swallowed. Alternatively, coca leaves can be infused in liquid and consumed like tea. Coca tea , an infusion of coca leaves, is also a traditional method of consumption. The tea has often been recommended for travelers in

7425-498: The script to previous iteration, while leaving most of Stallone's character revisions intact. However Proser found the task (and turnaround time) preposterous. " They offered me the rewrite when it was nothing more than Sylvester Stallone and an exotic gun—which was pretty ridiculous ", remembered screenwriter Chip Proser, who would later write [an uncredited rewrite of] Simpson and Bruckheimer's Top Gun . According to co-producer Don Simpson, Stallone’s new script spent too much time on

7524-565: The shrewdest, hippest, fastest-talking underdog in a rich man's world. Eddie Murphy knows exactly what he's doing, and he wins at every turn." Richard Schickel of Time magazine wrote that "Eddie Murphy exuded the kind of cheeky, cocky charm that has been missing from the screen since Cagney was a pup, snarling his way out of the ghetto." Axel Foley became Murphy's signature role and was ranked No. 78 on Empire magazine's list of The 100 Greatest Movie Characters of All Time . Entertainment Weekly magazine ranked Beverly Hills Cop as

7623-403: The star ' soaping down his muscles .' Stallone ultimately dropped out two weeks before filming was to start, ostensibly to concentrate on his next picture, the 1984 film Rhinestone . Stallone later used the bulk of these ideas as the basis for the 1986 film Cobra . Don Simpson would later tell friends a story—impossible to corroborate—about how he finally got Stallone off the project and got

7722-464: The stolen bonds, and murder him. Axel asks to be assigned to investigate Mikey's murder, but Inspector Todd won't allow it due to his close ties to Mikey. Under the guise of taking vacation time, Axel travels to Beverly Hills to solve the crime himself. He finds Jenny working in an art gallery and learns about Mikey's ties to Victor Maitland, the gallery's owner. Posing as a flower deliveryman, Axel goes to Maitland's office to question him about Mikey, but

7821-451: The study, "peak high" was found at a mean of 1.4 ± 0.5 minutes. Pyrolysis products of cocaine that occur only when heated/smoked have been shown to change the effect profile, i.e. anhydroecgonine methyl ester , when co-administered with cocaine, increases the dopamine in CPu and NAc brain regions, and has M 1 — and M 3 — receptor affinity. People often freebase crack with

7920-491: The sympathetic nerves are blocked, and the affected eye will remain constricted or dilate to a lesser extent than the opposing (unaffected) eye which also receives the eye drop test. If both eyes dilate equally, the patient does not have Horner syndrome. Topical cocaine is sometimes used as a local numbing agent and vasoconstrictor to help control pain and bleeding with surgery of the nose, mouth, throat or lacrimal duct . Although some absorption and systemic effects may occur,

8019-405: The synaptic cleft increase dopamine receptor activation in the post-synaptic neuron, causing euphoria and arousal. Cocaine also blocks the serotonin transporter and norepinephrine transporter , inhibiting reuptake of serotonin and norepinephrine from the synaptic cleft into the pre-synaptic axon terminal and increasing activation of serotonin receptors and norepinephrine receptors in

8118-437: The tea per day gave a mild stimulation , increased heart rate , and mood elevation, and the tea was essentially harmless. Nasal insufflation (known colloquially as "snorting", "sniffing", or "blowing") is a common method of ingestion of recreational powdered cocaine. The drug coats and is absorbed through the mucous membranes lining the nasal passages . Cocaine's desired euphoric effects are delayed when snorted through

8217-440: The term "Wunza Movie" to describe this subgenre, a pun on the phrase "One's a..." that could be used to describe the contrasts between the two characters in a typical film. The cliché was satirized in the film Last Action Hero . While the movie in itself was a buddy cop film (i.e. pairing a fictional cop with a real world boy), the film's police department obligatorily assigned all cops a conflicting buddy to work with, even to

8316-474: The third best comedy film of the last 25 years. According to Christopher Hitchens , the British novelist and poet Kingsley Amis considered the film "a flawless masterpiece." John Simon of National Review called Beverly Hills Cop "a truly contemptible film." In 2003, the film was picked by The New York Times as one of The 1000 Best Movies Ever Made . Beverly Hills Cop is in the permanent collection of

8415-470: The threat of breastfeeding : The March of Dimes said "it is likely that cocaine will reach the baby through breast milk," and advises the following regarding cocaine use during pregnancy: Cocaine use during pregnancy can affect a pregnant woman and her unborn baby in many ways. During the early months of pregnancy, it may increase the risk of miscarriage. Later in pregnancy, it can trigger preterm labor (labor that occurs before 37 weeks of pregnancy) or cause

8514-475: The three begin to develop a mutual respect after they foil a robbery at a striptease bar. Continuing his investigation, Axel sneaks into one of Maitland's warehouses, where he finds crates full of coffee grounds . He suspects they have been used to pack drugs, since he knows they are often used to cover the scent of drugs from police dogs. Axel also discovers that many of Maitland's crates have not gone through customs. After being arrested again, this time after

8613-432: The transporter's function. The dopamine transporter can no longer perform its reuptake function, and thus dopamine accumulates in the synaptic cleft . The increased concentration of dopamine in the synapse activates post-synaptic dopamine receptors, which makes the drug rewarding and promotes the compulsive use of cocaine. Cocaine affects certain serotonin (5-HT) receptors; in particular, it has been shown to antagonize

8712-480: The two in rescuing Jenny and bringing Maitland to justice. Together, the trio wipe out four of Maitland's men, including Zack. With Bogomil's help, Axel then kills Maitland and rescues Jenny. Bogomil fabricates a story to Hubbard that manages to cover for all the participants without discrediting the police department. Axel, realizing that his exploits while "on vacation" will likely get him fired, asks Bogomil to smooth matters over with Inspector Todd. When Axel mentions

8811-486: The urine. The metabolism is dominated by hydrolytic ester cleavage, so the eliminated metabolites consist mostly of benzoylecgonine (BE), the major metabolite , and other metabolites in lesser amounts such as ecgonine methyl ester (EME) and ecgonine . Further minor metabolites of cocaine include norcocaine , p-hydroxycocaine, m-hydroxycocaine, p-hydroxybenzoylecgonine (pOHBE), and m-hydroxybenzoylecgonine. If consumed with alcohol , cocaine combines with alcohol in

8910-408: The use of cocaine as a topical anesthetic and vasoconstrictor is generally safe, rarely causing cardiovascular toxicity, glaucoma , and pupil dilation . Occasionally, cocaine is mixed with adrenaline and sodium bicarbonate and used topically for surgery, a formulation called Moffett's solution . Cocaine hydrochloride ( Goprelto ), an ester local anesthetic, was approved for medical use in

9009-648: The user contracting blood-borne infections if sterile injecting equipment is not available or used. An injected mixture of cocaine and heroin , known as " speedball ", is a particularly dangerous combination, as the converse effects of the drugs actually complement each other, but may also mask the symptoms of an overdose. It has been responsible for numerous deaths, including celebrities such as comedians/actors John Belushi and Chris Farley , Mitch Hedberg , River Phoenix , grunge singer Layne Staley and actor Philip Seymour Hoffman . Experimentally, cocaine injections can be delivered to animals such as fruit flies to study

9108-486: The warehouse and discover several bags of cocaine inside a crate. Before he can get this new-found evidence to Billy, Maitland arrives with his associates Zack and Casey. Maitland takes Jenny and leaves Axel, ordering that he be killed. Zack then tells Axel that he was the one who killed Mikey. After some hesitation, Billy enters the warehouse and rescues Axel after a brief gunfight during which he kills Casey. Taggart tracks Axel and Billy to Maitland's estate, where he joins

9207-411: Was 14.6 minutes. Any damage to the inside of the nose is due to cocaine constricting blood vessels — and therefore restricting blood and oxygen/nutrient flow — to that area. Rolled up banknotes , hollowed-out pens , cut straws , pointed ends of keys, specialized spoons , long fingernails , and (clean) tampon applicators are often used to insufflate cocaine. The cocaine typically is poured onto

9306-510: Was a box office success, while the third film was unsuccessful, both critically and commercially. In 2013, a television series was reported to be in the works for CBS . The pilot was written by Shawn Ryan and directed by Barry Sonnenfeld . Brandon T. Jackson was cast as Axel Foley's son. The series was not picked up, but Ryan reported that it tested well enough for Paramount to put a fourth film into production. On November 14, 2019, Deadline Hollywood announced that Paramount Pictures made

9405-496: Was brought in to rewrite the script and Paramount loved Petrie's humorous approach to the project, with the lead character now called Axel Elly, from Detroit. Producer Jerry Bruckheimer claimed that the role of Axel Foley was first offered to Mickey Rourke , who signed a $ 400,000 holding contract to do the film. When revisions and other preparations took longer than expected, Rourke left the project to do another film. Martin Scorsese

9504-443: Was called in to write the screenplay. Bach pitched his idea to Simpson and Paramount in 1981 under the name Beverly Drive , about a cop from Pittsburgh named Elly Axel. However, his script was a straight action film and Bach was forced to make changes to the script, but after a few attempts the project went stale. With the success of Flashdance (1983), Simpson saw the Beverly Hills film as his next big project. Daniel Petrie Jr.

9603-623: Was not completed until the day production began. The film was budgeted at $ 14 million, including $ 4 million for Murphy, and was completed for around $ 13 million. Production began in May 1984 and continued into the summer, taking place mostly in and around Los Angeles. The opening sequence was filmed over several days in Michigan, in Detroit and nearby Wayne . Many scenes set in Beverly Hills were shot in Pasadena , as

9702-417: Was offered to direct the film but turned it down as he felt that the film's concept was too similar to Coogan's Bluff . David Cronenberg was also offered to direct the film but also turned it down. Sylvester Stallone was originally considered for the part of Foley. Stallone gave the script a dramatic rewrite, removing all the story's humor and turning the film back into a standard action movie. In one of

9801-682: Was taken by The Matrix Reloaded . Adjusted for inflation, it is the highest-grossing R-rated film of all time at the U.S. box office, with a total box office gross of $ 730,714,743 in 2024. Box Office Mojo estimates that the film sold over 67 million tickets in the US. On review aggregation website Rotten Tomatoes the film has an approval rating of 83% from 53 critics with an average rating of 7.3/10. The site's consensus reads, "The buddy cop movie continues its evolution unabated with this Eddie Murphy vehicle that's fast, furious, and funny." Janet Maslin of The New York Times wrote " Beverly Hills Cop finds Eddie Murphy doing what he does best: playing

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