8-706: BSH may refer to: Bacillithiol , a thiol compound found in bacteria Bahrain Specialist Hospital , a hospital in Bahrain Bayley Seton Hospital on Staten Island, New York, US Belarusian Socialist Hramada , a political party Bishan MRT station , station abbreviation British Shorthair , a breed of cat British Society for Haematology BSh , Köppen climate classification for hot semi-arid climates BSH Bosch and Siemens Home Appliances Bushey railway station , station code Bushel ,
16-611: A unit of dry volume Federal Maritime and Hydrographic Agency of Germany (German: Bundesamt für Seeschifffahrt und Hydrographie ) Topics referred to by the same term [REDACTED] This disambiguation page lists articles associated with the title BSH . If an internal link led you here, you may wish to change the link to point directly to the intended article. Retrieved from " https://en.wikipedia.org/w/index.php?title=BSH&oldid=1255225710 " Category : Disambiguation pages Hidden categories: Articles containing German-language text Short description
24-445: Is an ester of pyrophosphoric acid with the nucleoside uridine . UDP consists of the pyrophosphate group , the pentose sugar ribose , and the nucleobase uracil . UDP is an important factor in glycogenesis . Before glucose can be stored as glycogen in the liver and muscles , the enzyme UDP-glucose pyrophosphorylase forms a UDP-glucose unit by combining glucose 1-phosphate with uridine triphosphate , cleaving
32-502: Is different from Wikidata All article disambiguation pages All disambiguation pages Bacillithiol Bacillithiol ( BSH or Cys-GlcN-mal ) is a thiol compound found in Bacillus species. It is likely involved in maintaining cellular redox balance and plays a role in microbial resistance to the antibiotic fosfomycin . Chemically, it is a glycoside formed between L -cysteinyl- D -glucosamine and malic acid . It
40-407: The acetyl group . L -Cysteine is added to the resulting free amine, which completes the biosynthesis of the molecule. The cysteine-adding step is assumed to be carried out by the enzyme BshC on the basis of genetic knockout studies , but the activity of BshC has not been observed in vitro . Uridine diphosphate Uridine diphosphate , abbreviated UDP , is a nucleotide diphosphate . It
48-514: The antibiotic fosfomycin , suggesting that in these organisms the mechanism of fosfomycin resistance relies on the presence of bacillithiol. Furthermore, in vitro kinetic studies have established that bacillithiol is a preferred thiol substrate for the antibiotic resistance enzyme FosB. Bacillithiol is produced via the enzymes BshA, BshB, and BshC. BshA replaces the UDP group on UDP- N -acetylglucosamine with an L -malyl group. BshB then removes
56-419: The sensing of peroxides by Bacillus , but may also substitute for glutathione , which is the most common intracellular thiol in eukaryotes and some bacteria. Some of the genes involved in the biosynthesis of bacillithiol were identified and characterised in 2010. Bacteria engineered to be deficient in bacillithiol demonstrated increased sensitivity to various electrophilic xenobiotic compounds, including
64-450: Was isolated and identified (as its bacillithiol-S- bimane derivative) in 2009 from Staphylococcus aureus and Deinococcus radiodurans , although it was first detected in 2007, as an unidentified thiol in Bacillus anthracis . The naturally occurring free thiol form of bacillithiol has since been synthesised and characterised along with its biosynthetic precursors and its symmetrical disulfide. Bacillithiol appears to participate in
#276723