53630
4-452: 63857 ENSG00000135697 ENSMUSG00000031845 Q9HAY6 Q9JJS6 NM_017429 NM_001163028 NM_021486 NP_059125 NP_001156500 NP_067461 In enzymology , beta-carotene 15,15'-dioxygenase , ( EC 1.13.11.63 ) is an enzyme with systematic name beta-carotene:oxygen 15,15'-dioxygenase (bond-cleaving) . In human it is encoded by the BCO1 gene. This enzyme catalyses
8-691: A carbon chain greater than C 30 , with at least one unsubstituted β-ionone ring. This enzyme belongs to the (enzymatically-defined) family of oxidoreductases , specifically those acting on paired donors, with O 2 as oxidant and incorporation or reduction of oxygen. A related enzyme is β-carotene 15,15'-monooxygenase, coded for by the gene BCMO1, which symmetrically cleaves β-carotene into two retinal molecules. In general, carnivores are poor converters of ionone-containing carotenoids, and pure carnivores such as felids (cats) lack beta-carotene 15,15'-dioxygenase and beta-carotene 15,15'-monooxygenase and cannot convert any carotenoids to retinal, resulting in none of
12-512: The carotenoids being forms of vitamin A for these species. They must have preformed vitamin A in their diet. Beta-carotene 15,15'-dioxygenase belongs to the (similarity-defined) family of carotenoid oxygenases ( InterPro : IPR004294 ). Enzymes of this family contain a Fe active site, coordinated usually by four His residues. This EC 1.13 enzyme -related article is a stub . You can help Misplaced Pages by expanding it . Enzymology Too Many Requests If you report this error to
16-534: The following chemical reaction This is a cleavage reaction which cleaves β-carotene , utilizes molecular oxygen, is enhanced by the presence of bile salts and thyroxine , and generates two molecules of retinal . In humans, the enzyme is present in the small intestine and liver. The dioxygenase also asymmetrically cleaves beta-cryptoxanthin , trans -β-apo-8'-carotenal , beta-4'-apo-β-carotenal, alpha-carotene and gamma-carotene in decreasing order, creating one retinal molecule, all of these being substrates with
#623376