15-898: [REDACTED] Look up at1 in Wiktionary, the free dictionary. AT1 may refer to: Angiotensin II receptor type 1 Additional Tier 1 capital , see Contingent convertible bond Yamaha AT1 (1969-1971) motorcycle Ekspress AT1 , communications satellite AT1 in the Ekspress network AeroTech Release 1; tabletop wargame See also [ edit ] [REDACTED] Search for "at1" on Misplaced Pages. Angiotensin II receptor blocker (AT1 blocker) All pages with titles beginning with AT1 All pages with titles containing AT1 ATL (disambiguation) ATI (disambiguation) AT (disambiguation) [REDACTED] Topics referred to by
30-401: A class of G protein-coupled receptors with angiotensin II as their ligands . They are important in the renin–angiotensin system : they are responsible for the signal transduction of the vasoconstricting stimulus of the main effector hormone, angiotensin II . The AT 1 and AT 2 receptors share a sequence identity of ~30%, but have a similar affinity for angiotensin II, which
45-427: Is activated by the vasoconstricting peptide angiotensin II . The activated receptor in turn couples to G q/11 and thus activates phospholipase C and increases the cytosolic Ca concentrations, which in turn triggers cellular responses such as stimulation of protein kinase C . Activated receptor also inhibits adenylate cyclase in hepatocytes and activates various tyrosine kinases . The AT1 receptor mediates
60-667: Is contained in the terminal exon and is present in all transcript variants. A huge number of polymorphisms is reported in the databases for AT1R which provide an avenue to explore these polymorphisms for their implications in protein structure, function and drug efficacy. Methods In the current study all the SNPs (10234) reported in NCBI were analyzed and SNPs which were important in protein structure and drug interactions were identified. Structures of these polymorphic forms were modeled and in silico drug interaction studies were carried out. Results Result of
75-454: Is different from Wikidata All article disambiguation pages All disambiguation pages Angiotensin II receptor type 1 4YAY , 4ZUD 185 11607 ENSG00000144891 ENSMUSG00000049115 P30556 P29754 NM_001382736 NM_001382737 NM_177322 NP_001369665 NP_001369666 NP_796296 Angiotensin II receptor type 1 (AT1) is a G q/11 -coupled G protein-coupled receptor (GPCR) and
90-499: Is their main ligand. The AT 1 receptor is the best elucidated angiotensin receptor. The AT1 subtype is found in the heart, blood vessels, kidney, adrenal cortex, lung and circumventricular organs of brain, basal ganglia , brainstem and mediates the vasoconstrictor effects. The angiotensin receptor is activated by the vasoconstricting peptide angiotensin II . The activated receptor in turn couples to G q/11 and G i/o and thus activates phospholipase C and increases
105-541: The AT2 subtype is found in molecular layer of the cerebellum . In the mouse is found in the adrenal gland, amygdaloid nuclei and, in small numbers, in the paraventricular nucleus of the hypothalamus and the locus coeruleus. Other poorly characterized subtypes include the AT 3 and AT 4 receptors. The AT 4 receptor is activated by the angiotensin II metabolite angiotensin IV , and may play
120-468: The best characterized angiotensin receptor . It is encoded in humans by the AGTR1 gene . AT1 has vasopressor effects and regulates aldosterone secretion. It is an important effector controlling blood pressure and volume in the cardiovascular system . Angiotensin II receptor blockers are drugs indicated for hypertension , diabetic nephropathy and congestive heart failure . The angiotensin receptor
135-578: The brain is to stimulate drinking behavior, an effect that is mediated by the AT1 receptor. Due to the hemodynamic pressure and volume effects mediated by AT1 receptors, AT1 receptor antagonists are widely prescribed drugs in the management of hypertension and stable heart failure. Elements of the renin-angiotensin system have been widely studied in a large variety of vertebrate animals including amphibians, reptiles, birds, and mammals. AT1 receptor blockers have been shown to reduce fear memory recall in mice, but
150-761: The cytosolic Ca concentrations, which in turn triggers cellular responses such as stimulation of protein kinase C . Activated receptor also inhibits adenylate cyclase and activates various tyrosine kinases . Effects mediated by the AT 1 receptor include vasoconstriction , aldosterone synthesis and secretion, increased vasopressin secretion, cardiac hypertrophy , augmentation of peripheral noradrenergic activity , vascular smooth muscle cells proliferation, decreased renal blood flow, renal renin inhibition, renal tubular sodium reuptake, modulation of central sympathetic nervous system activity, cardiac contractility, central osmocontrol and extracellular matrix formation. AT 2 receptors are more plentiful in
165-417: The fetus and neonate. The AT 2 receptor remains enigmatic and controversial – is probably involved in vascular growth. Effects mediated by the AT 2 receptor are suggested to include inhibition of cell growth , fetal tissue development, modulation of extracellular matrix, neuronal regeneration, apoptosis , cellular differentiation , and maybe vasodilation and left ventricular hypertrophy . In humans
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#1732855127518180-624: The interaction studies with polymorphism was in correlation with the reported case. Two SNP mutated structures of AT1R i.e. rs780860717 (G288T), rs868647200 (A182C) shows considerably less binding affinities in case of all angiotensin receptor blockers (ARBs). Angiotensin II receptor type 1 has been shown to interact with Zinc finger and BTB domain-containing protein 16 . The protein's mRNA has been reported to interact with Mir-132 microRNA as part of an RNA silencing mechanism that reduces receptor expression. Angiotensin receptor The angiotensin II receptors , (ATR1) and (ATR2) , are
195-558: The major cardiovascular effects of angiotensin II. Effects include vasoconstriction , aldosterone synthesis and secretion, increased vasopressin secretion, cardiac hypertrophy, augmentation of peripheral noradrenergic activity , vascular smooth muscle cells proliferation, decreased renal blood flow, renal renin inhibition, renal tubular sodium reuptake, modulation of central sympathetic nervous system activity, cardiac contractility, central osmocontrol and extracellular matrix formation. The main function of angiotensin II in
210-423: The reliability and relevance of this finding are to be determined. It was previously thought that a related gene, denoted as AGTR1B , existed; however, it is now believed that there is only one type 1 receptor gene in humans. At least four transcript variants have been described for this gene. Additional variants have been described but their full-length nature has not been determined. The entire coding sequence
225-447: The same term This disambiguation page lists articles associated with the same title formed as a letter–number combination. If an internal link led you here, you may wish to change the link to point directly to the intended article. Retrieved from " https://en.wikipedia.org/w/index.php?title=AT1&oldid=952838761 " Category : Letter–number combination disambiguation pages Hidden categories: Short description
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