5-470: APDS may refer to: Activated PI3K Delta Syndrome Armour-piercing discarding sabot Augusta Preparatory Day School Androgynous Peripheral Docking System See also [ edit ] APD (disambiguation) Topics referred to by the same term [REDACTED] This disambiguation page lists articles associated with the title APDS . If an internal link led you here, you may wish to change
10-668: Is a primary immunodeficiency disease caused by activating gain of function mutations in the PIK3CD gene. The signs and symptoms of activated PI3K Delta Syndrome are consistent with the following: In terms of genetics, activated PI3K Delta Syndrome is autosomal dominant , a mutation in phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform is the reason for this condition (located at chromosome 1p36.) The pathophysiology of activated PI3K delta syndrome has several aspects. The normal function has P110δ (PI3K) involved in immune system regulation. P110δ effect
15-472: Is not limited to the immune system; P110δ has a presence in transformed epithelial cells and cell adhesion molecules (airway inflammation), and research has been done on the possibility of P110δ in the nervous system . Activated PI3K delta syndrome effect indicates affected individuals are likely to have activation-induced cell death . Normally, PI3K-delta signaling assists B cells and T cells to mature; however, overactive PI3K-delta has an effect on
20-504: The B and T cell differentiation (the process by which cells eventually are different from one another ). Consequently, there is an inability to confront an infection, as well as early cell death. Furthermore, overproduction of said signal can cause lymphadenopathy (which is an enlargement of lymph nodes ) due to excess white blood cells . In order to ascertain if an individual has activated PI3K delta syndrome, usually one finds atypical levels of immunoglobulins . Methods to determine
25-414: The link to point directly to the intended article. Retrieved from " https://en.wikipedia.org/w/index.php?title=APDS&oldid=1172225711 " Category : Disambiguation pages Hidden categories: Short description is different from Wikidata All article disambiguation pages All disambiguation pages Activated PI3K Delta Syndrome Activated PI3K delta syndrome (APDS)
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