108-506: Uhuru Gardens National Monument and Museum is a commemorative park and museum in Nairobi , Kenya that celebrates independence from the British Empire on 12 December 1963. The word "uhuru" is Swahili for "freedom". It contains three points of significance: Nairobi Nairobi ( / n aɪ ˈ r oʊ b i / ny- ROH -bee ) is the capital and largest city of Kenya . The name
216-520: A city-county . The county is entirely urban. It had only one local council, Nairobi City Council which was replaced by Nairobi City County after the new constitution was effected in March 2013. Nairobi County has 17 constituencies. Constituency name may differ from division name, such that Starehe Constituency is equal to Central Division, Lang'ata Constituency to Kibera division, and Kamukunji Constituency to Pumwani Division in terms of boundaries. Nairobi
324-575: A blood meal from a previously Plasmodium infected person or animal. Parasites are then typically introduced by the bite of an infected Anopheles mosquito. Some of these inoculated parasites, called " sporozoites ", probably remain in the skin, but others travel in the bloodstream to the liver , where they invade hepatocytes . They grow and divide in the liver for 2–10 days, with each infected hepatocyte eventually harboring up to 40,000 parasites. The infected hepatocytes break down, releasing these invasive Plasmodium cells, called " merozoites ", into
432-501: A campaign by Nobel Peace Prize winner Wangari Maathai . Central Park is adjacent to Uhuru Park, and includes a memorial for Jomo Kenyatta , the first president of Kenya, and the Moi Monument, built in 1988 to commemorate the second president's first decade in power. Other notable open spaces include Jeevanjee Gardens , City Park, 7 August Memorial Park , and Nairobi Arboretum. The colonial 1948 Master Plan for Nairobi still acts as
540-462: A child under five died of malaria in 2021, and "many of these deaths are preventable and treatable". Malaria is commonly associated with poverty and has a significant negative effect on economic development. In Africa, it is estimated to result in losses of US$ 12 billion a year due to increased healthcare costs, lost ability to work, and adverse effects on tourism. The term malaria originates from Medieval Italian : mala aria 'bad air',
648-414: A consistent supply of microscopy slides and stains. In places where microscopy is unavailable, malaria is diagnosed with RDTs, rapid antigen tests that detect parasite proteins in a fingerstick blood sample. A variety of RDTs are commercially available, targeting the parasite proteins histidine rich protein 2 (HRP2, detects P. falciparum only), lactate dehydrogenase , or aldolase . The HRP2 test
756-674: A day. It also contains the Nairobi National Park . Nairobi joined the UNESCO Global Network of Learning Cities in 2010. Nairobi was founded in 1899 by colonial authorities in British East Africa , as a rail depot on the Uganda - Kenya Railway. It was favoured by the authorities as an ideal resting place due to its high elevation , temperate climate , and adequate water supply. The town quickly grew to replace Mombasa as
864-444: A dual carriageway passenger access road, security, drainage and the building of the main access road to the airport (Airport South Road). The total cost of the project was more than US$ 29 million (US$ 111.8 million in 2013 dollars). On 14 March 1978, construction of the terminal building was completed on the other side of the airport's single runway and opened by President Jomo Kenyatta less than five months before his death. The airport
972-472: A greater likelihood of complications and death. Malaria infection affects the immune responses following vaccination for various diseases. For example, malaria suppresses immune responses to polysaccharide vaccines. A potential solution is to give curative treatment before vaccination in areas where malaria is present. Due to the non-specific nature of malaria symptoms, diagnosis is typically suspected based on symptoms and travel history, then confirmed with
1080-874: A hub. Nairobi has not been left behind by the FinTech phenomenon that has taken over worldwide. It has produced a couple of tech firms like Craft Silicon, Kangai Technologies, Jambo Pay and Hostraha Limited Archived 16 November 2022 at the Wayback Machine . which have been in the forefront of technology, innovation and cloud based computing services. Their products are widely used and have considerable market share presence within Kenya and outside its borders. Goods manufactured in Nairobi include clothing, textiles, building materials, processed foods , beverages, and cigarettes. Several foreign companies have factories based in and around
1188-453: A laboratory test showing hemoglobin levels below 8 grams per deciliter of blood. In areas of the world with little to no malaria, the WHO recommends only testing people with possible exposure to malaria (typically travel to a malaria-endemic area) and unexplained fever. In sub-Saharan Africa, testing is low, with only about one in four (28%) of children with a fever receiving medical advice or
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#17328695634561296-477: A laboratory test to detect the presence of the parasite in the blood (parasitological test). In areas where malaria is common, the World Health Organization (WHO) recommends clinicians suspect malaria in any person who reports having fevers, or who has a current temperature above 37.5 °C without any other obvious cause. Malaria should be suspected in children with signs of anemia : pale palms or
1404-534: A large amount of sweat on the surface of the skin. Due to the high levels of lactic acid released from the human body, it has been hypothesized to represent a specific human host-recognition cue for anthropophilic (attracted to humans) mosquitoes. Pungent foot odor Most studies use human odors as stimuli to attract host seeking mosquitoes and have reported a strong and significant attractive effect. The studies have found human odor samples very effective in attracting mosquitoes. Foot odors have been demonstrated to have
1512-636: A less pronounced and almost continuous fever. Symptoms typically begin 10–15 days after the initial mosquito bite, but can occur as late as several months after infection with some P. vivax strains. Travellers taking preventative malaria medications may develop symptoms once they stop taking the drugs. Severe malaria is usually caused by P. falciparum (often referred to as falciparum malaria). Symptoms of falciparum malaria arise 9–30 days after infection. Individuals with cerebral malaria frequently exhibit neurological symptoms, including abnormal posturing , nystagmus , conjugate gaze palsy (failure of
1620-435: A non-invasive way to detect malarial infections. In addition, these volatile compounds were heavily detected by mosquito antennae as an attractant, making the children more vulnerable to the bite of the mosquitos. Fatty acids Fatty acids have been identified as an attractive compound for mosquitoes, they are typically found in volatile emissions from the skin. These fatty acids that produce body odor profiles originate from
1728-559: A part of miasma theory ; the disease was formerly called ague or marsh fever due to its association with swamps and marshland. The term appeared in English at least as early as 1768. Malaria was once common in most of Europe and North America, where it is no longer endemic, though imported cases do occur. The scientific study of malaria is called malariology. Adults with malaria tend to experience chills and fever—classically in periodic intense bouts lasting around six hours, followed by
1836-530: A period of sweating and fever relief—as well as headache, fatigue, abdominal discomfort, and muscle pain . Children tend to have more general symptoms: fever, cough, vomiting, and diarrhea. Initial manifestations of the disease—common to all malaria species—are similar to flu-like symptoms , and can resemble other conditions such as sepsis , gastroenteritis , and viral diseases . The presentation may include headache , fever , shivering , joint pain , vomiting , hemolytic anemia , jaundice , hemoglobin in
1944-562: A postdoctoral scholar at the University of California, Berkeley studying the structural basis of membrane manipulation and cell-cell fusion by bacterial pathogens, discusses studies that determine how odor profiles can be used to diagnose the disease. Within the study, samples of volatile compounds from around 400 children within schools in Western Kenya were collected - to identify asymptomatic infections. These biomarkers have been established as
2052-626: A rapid diagnostic test in 2021. There was a 10-percentage point gap in testing between the richest and the poorest children (33% vs 23%). Additionally, a greater proportion of children in Eastern and Southern Africa (36%) were tested than in West and Central Africa (21%). According to UNICEF, 61% of children with a fever were taken for advice or treatment from a health facility or provider in 2021. Disparities are also observed by wealth, with an 18 percentage point difference in care-seeking behaviour between children in
2160-452: A series of US embassy bombings . It is now the site of a memorial park. On 20 October 2011, a memorial statue was unveiled in Nairobi in memory to Tom Mboya , a former Kenyan Independence politician and assassination victim. On 9 November 2012, President Mwai Kibaki opened the KES 31 billion Thika Superhighway. This mega-project of Kenya started in 2009 and ended in 2011. It involved expanding
2268-466: A short time, and a "thin film" of blood, allowing them to clearly see individual parasites and identify the infecting Plasmodium species. Under typical field laboratory conditions, a microscopist can detect parasites when there are at least 100 parasites per microliter of blood, which is around the lower range of symptomatic infection. Microscopic diagnosis is relatively resource intensive, requiring trained personnel, specific equipment, electricity, and
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#17328695634562376-579: A small proportion of public expenditure on health. In contrast, a similar programme in Tanzania would cost an estimated one-fifth of the public health budget. In 2021, the World Health Organization confirmed that China has eliminated malaria. In 2023, the World Health Organization confirmed that Azerbaijan , Tajikistan , and Belize have eliminated malaria. In areas where malaria is common, children under five years old often have anaemia , which
2484-561: A thing of beauty has been slowly worked out, and much has already been done. But until that plan has borne fruit, Nairobi must remain what she was then, a slatternly creature, unfit to queen it over so lovely a country. After World War II , continuous expansion of the city angered both the indigenous Maasai and Kikuyu . This led to the Mau Mau Uprising in the 1950s, and the Lancaster House Conferences , which initiated
2592-604: A transition to Kenyan independence in 1963. In the spring of 1950, the East African Trades Union Congress (EAUTC) led a nine-day general strike in the city. Nairobi remained the capital of Kenya after independence, and its continued rapid growth put pressure on the city's infrastructure with power cuts and water shortages becoming a common occurrence. On 11 September 1973, the Kenyatta International Conference Centre KICC
2700-510: A way past the net. Insecticide-treated nets (ITNs) are estimated to be twice as effective as untreated nets and offer greater than 70% protection compared with no net. Between 2000 and 2008, the use of ITNs saved the lives of an estimated 250,000 infants in Sub-Saharan Africa. According to UNICEF, only 36% of households had sufficient ITNs for all household members in 2019. In 2000, 1.7 million (1.8%) African children living in areas of
2808-527: Is Uhuru Park . The park borders the central business district and the neighbourhood Upper Hill. Uhuru ( Freedom in Swahili ) Park is a centre for outdoor speeches, services, and rallies. The park was to be built over by former President Daniel arap Moi , who wanted the 62-storey headquarters of his party, the Kenya African National Union , situated in the park. However, the park was saved following
2916-479: Is a feature of blackwater fever , where haemoglobin from lysed red blood cells leaks into the urine. Infection with P. falciparum may result in cerebral malaria, a form of severe malaria that involves encephalopathy . It is associated with retinal whitening, which may be a useful clinical sign in distinguishing malaria from other causes of fever. An enlarged spleen , enlarged liver or both of these , severe headache, low blood sugar , and haemoglobin in
3024-518: Is associated with potentially life-threatening conditions about as often as with a diagnosis of P. falciparum infection. P. vivax proportionally is more common outside Africa. Some cases have been documented of human infections with several species of Plasmodium from higher apes , but except for P. knowlesi —a zoonotic species that causes malaria in macaques —these are mostly of limited public health importance. The Anopheles mosquitos initially get infected by Plasmodium by taking
3132-446: Is caused by six Plasmodium species: P. falciparum , P. malariae , P. ovale curtisi , P. ovale wallikeri , P. vivax and P. knowlesi . Among those infected, P. falciparum is the most common species identified (~75%) followed by P. vivax (~20%). Although P. falciparum traditionally accounts for the majority of deaths, recent evidence suggests that P. vivax malaria
3240-448: Is claimed by the Kenyan government to have a population of 185,777. However, non-governmental sources generally estimate the slum to have a population of 500,000 to 1,000,000, depending on what areas are defined as comprising Kibera. Nairobi has many parks and open spaces throughout the city. Much of the city has dense tree-cover and plenty of green spaces. The most famous park in Nairobi
3348-646: Is commemorated by many English place-names. Most lower-middle and upper middle income neighbourhoods are located in the north-central areas such as Highridge, Parklands, Ngara, Pangani, and areas to the southwest and southeast of the metropolitan area near the Jomo Kenyatta International Airport. The most notable ones include Avenue Park, Fedha, Pipeline, Donholm, Greenfields, Nyayo, Taasia, Baraka, Nairobi West, Madaraka, Siwaka, South B, South C, Mugoya, Riverbank, Hazina, Buru Buru, Uhuru, Harambee Civil Servants', Akiba, Kimathi, Pioneer, and Koma Rock to
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3456-465: Is deemed severe when any of the following criteria are present, otherwise it is considered uncomplicated. Cerebral malaria is defined as a severe P. falciparum -malaria presenting with neurological symptoms, including coma (with a Glasgow coma scale less than 11, or a Blantyre coma scale less than 3), or with a coma that lasts longer than 30 minutes after a seizure. Methods used to prevent malaria include medications, mosquito elimination and
3564-676: Is derived from the Maasai phrase Enkare Nairobi , which translates to 'place of cool waters', a reference to the Nairobi River which flows through the city. The city proper had a population of 4,397,073 in the 2019 census. The city is commonly referred to as 'The Green City in the Sun'. Nairobi is home of the Kenyan Parliament Buildings and hosts thousands of Kenyan businesses and key international companies and organisations, including
3672-522: Is divided into 17 constituencies and 85 wards , mostly named after residential estates. Kibera Division, for example, includes Kibera (Kenya's largest slum) as well as affluent estates of Karen and Langata . The Nairobi GPO (General Post Office) Postal code is 00100 Nairobi is home to the Nairobi Securities Exchange (NSE), one of Africa's largest stock exchanges . The NSE was officially recognised as an overseas stock exchange by
3780-531: Is insufficient evidence that mosquito repellents can prevent malaria infection. Insecticide-treated nets (ITNs) and indoor residual spraying (IRS) are effective, have been commonly used to prevent malaria, and their use has contributed significantly to the decrease in malaria in the 21st century. ITNs and IRS may not be sufficient to eliminate the disease, as these interventions depend on how many people use nets, how many gaps in insecticide there are (low coverage areas), if people are not protected when outside of
3888-451: Is not available. In areas where the disease is common, malaria should be confirmed if possible before treatment is started due to concerns of increasing drug resistance . Resistance among the parasites has developed to several antimalarial medications; for example, chloroquine -resistant P. falciparum has spread to most malarial areas, and resistance to artemisinin has become a problem in some parts of Southeast Asia . The disease
3996-400: Is relatively invisible to immune surveillance. However, circulating infected blood cells are destroyed in the spleen . To avoid this fate, the P. falciparum parasite displays adhesive proteins on the surface of the infected blood cells, causing the blood cells to stick to the walls of small blood vessels, thereby sequestering the parasite from passage through the general circulation and
4104-496: Is situated between the cities of Kampala and Mombasa. As Nairobi is adjacent to the eastern edge of the Rift Valley , minor earthquakes and tremors occasionally occur. The Ngong Hills , located to the west of the city, are the most prominent geographical feature of the Nairobi area. Mount Kenya is situated north of Nairobi, and Mount Kilimanjaro is towards the south-east. The Nairobi River and its tributaries traverse through
4212-463: Is situated close to the equator, the differences between the seasons are minimal. The seasons are referred to as the wet season and dry season . The timing of sunrise and sunset varies little throughout the year for the same reason. Nairobi is divided into a series of constituencies with each being represented by members of Parliament in the National Assembly. The initial constituencies before
4320-449: Is sometimes due to malaria. Giving children with anaemia in these areas preventive antimalarial medication improves red blood cell levels slightly but does not affect the risk of death or need for hospitalisation. Vector control refers to methods used to decrease malaria by reducing the levels of transmission by mosquitoes. For individual protection, the most effective insect repellents are based on DEET or picaridin . However, there
4428-408: Is spread exclusively through bites of infected female Anopheles mosquitoes. The mosquito bite introduces the parasites from the mosquito's saliva into a person's blood. The parasites travel to the liver , where they mature and reproduce. Five species of Plasmodium commonly infect humans. The three species associated with more severe cases are P. falciparum (which is responsible for
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4536-425: Is typical) to several years. After a period of dormancy, they reactivate and produce merozoites. Hypnozoites are responsible for long incubation and late relapses in P. vivax infections, although their existence in P. ovale is uncertain. The parasite is relatively protected from attack by the body's immune system because for most of its human life cycle it resides within the liver and blood cells and
4644-413: Is typically attributed to treatment failure. People may develop some immunity when exposed to frequent infections. Malaria infection develops via two phases: one that involves the liver (exoerythrocytic phase), and one that involves red blood cells, or erythrocytes (erythrocytic phase). When an infected mosquito pierces a person's skin to take a blood meal, sporozoites in the mosquito's saliva enter
4752-806: Is widely used in Africa, where P. falciparum predominates. However, since HRP2 persists in the blood for up to five weeks after an infection is treated, an HRP2 test sometimes cannot distinguish whether someone currently has malaria or previously had it. Additionally, some P. falciparum parasites in the Amazon region lack the HRP2 gene, complicating detection. RDTs are fast and easily deployed to places without full diagnostic laboratories. However they give considerably less information than microscopy, and sometimes vary in quality from producer to producer and lot to lot. Serological tests to detect antibodies against Plasmodium from
4860-562: Is widespread in the tropical and subtropical regions that exist in a broad band around the equator . This includes much of sub-Saharan Africa , Asia , and Latin America . In 2022, some 249 million cases of malaria worldwide resulted in an estimated 608,000 deaths, with 80 percent being five years old or less. Around 95% of the cases and deaths occurred in sub-Saharan Africa. Rates of disease decreased from 2010 to 2014, but increased from 2015 to 2021. According to UNICEF, nearly every minute,
4968-489: The London Stock Exchange in 1953. The exchange is Africa's fourth largest in terms of trading volumes, and fifth largest in terms of Market Capitalization as a percentage of GDP. Nairobi is the regional headquarters of several international companies and organisations. In 2007, General Electric , Young & Rubicam , Google , Coca-Cola , IBM Services , and Cisco Systems relocated their African headquarters to
5076-533: The Maasai , the sedentary Akamba People , as well as the agriculturalist Kikuyu people . The name Nairobi itself comes from the Maasai expression meaning 'cool waters', referring to the cold water stream which flowed through the area. With the arrival of the Uganda Railway , the site was identified by Sir George Whitehouse for a store depot, shunting ground and camping ground for the Indian labourers working on
5184-555: The United Nations Environment Programme (UN Environment) and the United Nations Office at Nairobi (UNON). Nairobi is an established hub for business and culture. The Nairobi Securities Exchange (NSE) is one of the largest stock exchanges in Africa and the second-oldest exchange on the continent. It is Africa's fourth-largest stock exchange in terms of trading volume, capable of making 10 million trades
5292-411: The bone marrow for 11 days, then return to the blood circulation to await uptake by the bite of another mosquito. Once inside a mosquito, the gametocytes undergo sexual reproduction, and eventually form daughter sporozoites that migrate to the mosquito's salivary glands to be injected into a new host when the mosquito bites. The liver infection causes no symptoms; all symptoms of malaria result from
5400-491: The polymerase chain reaction to detect the parasite's DNA have been developed, but they are not widely used in areas where malaria is common, due to their cost and complexity. The risk of disease can be reduced by preventing mosquito bites through the use of mosquito nets and insect repellents or with mosquito-control measures such as spraying insecticides and draining standing water . Several medications are available to prevent malaria for travellers in areas where
5508-424: The 1980s. The City of Nairobi enjoys the status of a full administrative county . Initially, Nairobi was one of the eight provinces in Kenya before 2013. The Nairobi province differed in several ways from other Kenyan regions. Nairobi Province was not divided into "districts" until 2007, when three districts were created. In 2010, along with the new constitution, Nairobi was renamed a county and consolidated into
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#17328695634565616-591: The 2010 constitution which led to the county electoral boundaries being redrawn were: Makadara, Kamukunji, Starehe, Langata , Dagoretti, Westlands , Kasarani, and Embakasi . The new electoral boundaries after this were revised to Embakasi North, Embakasi South, Embakasi Central, Embakasi East, Embakasi West, Makadara, Kamukunji, Starehe, Mathare, Westlands, Dagoretti North, Dagoretti South, Langata, Kibra, Ruaraka, Roysambu and Kasarani. The main administrative divisions of Nairobi are Central, Dagoretti, Embakasi , Kasarani, Kibera , Makadara, Pumwani, and Westlands . Most of
5724-538: The City Hall and Parliament Building. The city square is also located within the perimeter. Most of the skyscrapers in this region are the headquarters of businesses and corporations, such as I&M and the Kenyatta International Conference Centre . The United States Embassy bombing took place in this district, prompting the building of a new embassy building in the suburbs. In 2011, the city
5832-552: The June/July season, when the temperature can drop to 9 °C (48 °F). The sunniest and warmest part of the year is from December to March, when temperatures average in the high-twenties Celsius during the day. The mean maximum temperature for this period is 28 °C (82 °F). There are rainy seasons, but rainfall can be moderate. The cloudiest part of the year is just after the first rainy season, when, until September, conditions are usually overcast with drizzle. As Nairobi
5940-599: The Nairobi County and joins the larger River Athi on the eastern edge of the county. Nobel Peace Prize laureate Wangari Maathai fought fiercely to save the indigenous Karura Forest in northern Nairobi which was under threat of being replaced by housing and other infrastructure. Nairobi's western suburbs stretch all the way from the Kenyatta National Hospital in the south to the UN headquarters at Gigiri suburb in
6048-534: The Standard Gauge Railway which connects Nairobi to Mombasa. It was primarily built by a Chinese firm with about 90% of total funding from China and about 10% from the Kenyan government. A second phase is also being built which will link Naivasha to the existing route and also the Uganda border. On 11 August 2020, Nairobi County Assembly Speaker Beatrice Elachi resigned. On 21 December 2020, recently elected Nairobi County Assembly Speaker Benson Mutura
6156-405: The absence of Duffy antigens on red blood cells. The impact of sickle cell trait on malaria immunity illustrates some evolutionary trade-offs that have occurred because of endemic malaria. Sickle cell trait causes a change in the haemoglobin molecule in the blood. Normally, red blood cells have a very flexible, biconcave shape that allows them to move through narrow capillaries ; however, when
6264-418: The blood have been developed, but are not used for malaria diagnosis due to their relatively poor sensitivity and specificity. Highly sensitive nucleic acid amplification tests have been developed, but are not used clinically due to their relatively high cost, and poor specificity for active infections. Malaria is classified into either "severe" or "uncomplicated" by the World Health Organization (WHO). It
6372-430: The bloodstream and migrate to the liver where they infect hepatocytes, multiplying asexually and asymptomatically for a period of 8–30 days. After a potential dormant period in the liver, these organisms differentiate to yield thousands of merozoites, which, following rupture of their host cells, escape into the blood and infect red blood cells to begin the erythrocytic stage of the life cycle. The parasite escapes from
6480-540: The bloodstream. In the blood, the merozoites rapidly invade individual red blood cells , replicating over 24–72 hours to form 16–32 new merozoites. The infected red blood cell lyses, and the new merozoites infect new red blood cells, resulting in a cycle that continuously amplifies the number of parasites in an infected person. Over rounds of this infection cycle, a small portion of parasites do not replicate, but instead develop into early sexual stage parasites called male and female " gametocytes ". These gametocytes develop in
6588-408: The brain, they contribute to coma . In the placenta they contribute to low birthweight and preterm labor, and increase the risk of abortion and stillbirth. The destruction of red blood cells during infection often results in anemia, exacerbated by reduced production of new red blood cells during infection. Only female mosquitoes feed on blood; male mosquitoes feed on plant nectar and do not transmit
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#17328695634566696-455: The capital of Kenya in 1907. After independence in 1963, Nairobi became the capital of the Republic of Kenya . During Kenya's early period, the city became a centre for the coffee , tea and sisal industries. The city lies in the south central part of Kenya, at an elevation of 1,795 metres (5,889 ft). The site of Nairobi was originally a swamp land occupied by a pastoralist people,
6804-434: The cause, recurrence can be classified as either recrudescence , relapse , or reinfection. Recrudescence is when symptoms return after a symptom-free period due to failure to remove blood-stage parasites by adequate treatment. Relapse is when symptoms reappear after the parasites have been eliminated from the blood but have persisted as dormant hypnozoites in liver cells. Relapse commonly occurs between 8 and 24 weeks after
6912-400: The centre-east and Kasarani to northeast area among others. The low and lower income estates are located mainly in far eastern Nairobi. These include, Umoja, Kariokor, Dandora , Kariobangi , Kayole , Ruai , Kamulu , Embakasi , and Huruma . Kitengela suburb, though located further southeast, Ongata Rongai and Kiserian further southwest, and Ngong/Embulbul suburbs also known as 'Diaspora' to
7020-469: The city. The United Nations Office at Nairobi hosts UN Environment and UN-Habitat headquarters. Several of Africa's largest companies are headquartered in Nairobi. Safaricom , the largest company in Kenya by assets and profitability is headquartered in Nairobi, KenGen, which is the largest African stock outside South Africa , is based in the city. Kenya Airways , Africa's fourth largest airline, uses Nairobi's Jomo Kenyatta International Airport as
7128-503: The city. These include Goodyear Tire and Rubber Company , General Motors , Toyota , and The Coca-Cola Company . Nairobi has a large tourist industry , being both a tourist destination and a transport hub. Nairobi has grown around its central business district . This takes a pentagonal shape, around the Uhuru Highway, Haile Selassie Avenue, Moi Avenue, and University Way. It features many of Nairobi's important buildings, including
7236-529: The city: Maybe one day Nairobi will be laid out with tarred roads, with avenues of flowering trees, flanked by noble buildings; with open spaces and stately squares; a cathedral worthy of faith and country; museums and of art; theatres and public offices. And it is fair to say that the Government and the Municipality have already bravely tackled the problem and that a town-plan ambitious enough to turn Nairobi into
7344-521: The development of respiratory distress , which occurs in up to 25% of adults and 40% of children with severe P. falciparum malaria. Possible causes include respiratory compensation of metabolic acidosis , noncardiogenic pulmonary oedema , concomitant pneumonia , and severe anaemia . Although rare in young children with severe malaria, acute respiratory distress syndrome occurs in 5–25% of adults and up to 29% of pregnant women. Coinfection of HIV with malaria increases mortality. Kidney failure
7452-504: The disease in the long run, but the initial costs required are out of reach of many of the world's poorest people. There is a wide difference in the costs of control (i.e. maintenance of low endemicity) and elimination programs between countries. For example, in China—whose government in 2010 announced a strategy to pursue malaria elimination in the Chinese provinces —the required investment is
7560-578: The disease is common. Occasional doses of the combination medication sulfadoxine/pyrimethamine are recommended in infants and after the first trimester of pregnancy in areas with high rates of malaria. As of 2023, two malaria vaccines have been endorsed by the World Health Organization . The recommended treatment for malaria is a combination of antimalarial medications that includes artemisinin . The second medication may be either mefloquine , lumefantrine , or sulfadoxine/pyrimethamine. Quinine , along with doxycycline , may be used if artemisinin
7668-469: The disease months later. In those who have recently survived an infection, reinfection usually causes milder symptoms. This partial resistance disappears over months to years if the person has no continuing exposure to malaria. The mosquito vector is itself harmed by Plasmodium infections, causing reduced lifespan. Human malaria is caused by single-celled microorganisms of the Plasmodium group. It
7776-462: The disease. Females of the mosquito genus Anopheles prefer to feed at night. They usually start searching for a meal at dusk, and continue through the night until they succeed. However, in Africa, due to the extensive use of bed nets, they began to bite earlier, before bed-net time. Malaria parasites can also be transmitted by blood transfusions , although this is rare. Symptoms of malaria can recur after varying symptom-free periods. Depending upon
7884-494: The eyes to turn together in the same direction), opisthotonus , seizures , or coma . Diagnosis based on skin odor profiles Humans emanate a large range of smells. Studies have been conducted on how to detect human malaria infections through volatile compounds from the skin - suggesting that volatile biomarkers may be a reliable source for the detection of infection, including those asymptomatic. Using skin body odor profiles can be efficient in diagnosing global populations, and
7992-598: The far west are considered part of the Greater Nairobi Metropolitan area. More than 90% of Nairobi residents work within the Nairobi Metropolitan area, in the formal and informal sectors. Many Somali immigrants have also settled in Eastleigh , nicknamed "Little Mogadishu ". Here is the list of all postal codes for Nairobi Archived 19 March 2023 at the Wayback Machine . The Kibera slum in Nairobi
8100-399: The four-lane carriageway to eight lanes, building underpasses, providing interchanges at roundabouts, erecting flyovers and building underpasses to ease congestion. The 50.4-kilometre road was built in three phases: Uhuru Highway to Muthaiga Roundabout; Muthaiga Roundabout to Kenyatta University and; Kenyatta University to Thika Town . On 31 May 2017, President Uhuru Kenyatta inaugurated
8208-442: The frequency with which malaria parasites complete their life cycle in the cell. Individuals who are homozygous (with two copies of the abnormal haemoglobin beta allele ) have sickle-cell anaemia , while those who are heterozygous (with one abnormal allele and one normal allele) experience resistance to malaria without severe anaemia. Although the shorter life expectancy for those with the homozygous condition would tend to disfavour
8316-564: The governing mechanism when it comes to making decisions related to urban planning. The Master Plan at the time, which was designed for 250,000 people, allocated 28% of Nairobi's land to public space, but because of rapid population growth, much of the vitality of public spaces within the city are increasingly threatened. City Park, the only natural park in Nairobi, for example, was originally 60 ha (150 acres), but has since lost approximately 20 ha (50 acres) of land to private development through squatting and illegal alienation which began in
8424-466: The headquarters of the provincial administration for the Ukamba province. On the arrival of the railway, Whitehouse remarked that "Nairobi itself will in the course of the next two years become a large and flourishing place and already there are many applications for sites for hotels, shops and houses." The town's early years were however beset with problems of malaria leading to at least one attempt to have
8532-399: The highest attractiveness to anthropophilic mosquitoes. Some of these studies have included traps that had been baited with nylon socks previously worn by human participants and were deemed efficient in catching adult mosquitos. Foot odors have high numbers of volatile compounds, which in turn elicit an olfactory response from mosquitoes. Malaria has several serious complications , including
8640-429: The home, and an increase in mosquitoes that are resistant to insecticides. Modifications to people's houses to prevent mosquito exposure may be an important long term prevention measure. Mosquito nets help keep mosquitoes away from people and reduce infection rates and transmission of malaria. Nets are not a perfect barrier and are often treated with an insecticide designed to kill the mosquito before it has time to find
8748-423: The infection of red blood cells. Symptoms develop once there are more than around 100,000 parasites per milliliter of blood. Many of the symptoms associated with severe malaria are caused by the tendency of P. falciparum to bind to blood vessel walls, resulting in damage to the affected vessels and surrounding tissue. Parasites sequestered in the blood vessels of the lung contribute to respiratory failure . In
8856-502: The initial symptoms and is often seen in P. vivax and P. ovale infections. P. vivax malaria cases in temperate areas often involve overwintering by hypnozoites, with relapses beginning the year after the mosquito bite. Reinfection means that parasites were eliminated from the entire body but new parasites were then introduced. Reinfection cannot readily be distinguished from relapse and recrudescence, although recurrence of infection within two weeks of treatment ending
8964-634: The liver undetected by wrapping itself in the cell membrane of the infected host liver cell. Within the red blood cells, the parasites multiply further, again asexually, periodically breaking out of their host cells to invade fresh red blood cells. Several such amplification cycles occur. Thus, classical descriptions of waves of fever arise from simultaneous waves of merozoites escaping and infecting red blood cells. Some P. vivax sporozoites do not immediately develop into exoerythrocytic-phase merozoites, but instead, produce hypnozoites that remain dormant for periods ranging from several months (7–10 months
9072-431: The metabolism of glycerol, lactic acid, amino acids, and lipids - through the action of bacteria found within the skin. They create a “chemical signature” for the mosquitoes to locate a potential host, humans in particular. Lactic acid Lactic acid, a naturally produced levorotatory isomer, has been titled an attractant of mosquitoes for a long time. Lactic acid is predominantly produced by eccrine-sweat glands, creating
9180-504: The modified haemoglobin S molecules are exposed to low amounts of oxygen, or crowd together due to dehydration, they can stick together forming strands that cause the cell to distort into a curved sickle shape. In these strands, the molecule is not as effective in taking or releasing oxygen, and the cell is not flexible enough to circulate freely. In the early stages of malaria, the parasite can cause infected red cells to sickle, and so they are removed from circulation sooner. This reduces
9288-797: The north, a distance of about 20 kilometres (12 mi). The city is centred on the City Square, which is located in the Central Business District. The Kenyan Parliament buildings, the Holy Family Cathedral , Nairobi City Hall, Nairobi Law Courts, and the Kenyatta Convention Centre all surround the square. Under the Köppen climate classification , Nairobi has a subtropical highland climate (Cwb). At 1,795 metres (5,889 ft) above sea level, evenings may be cool, especially in
9396-624: The parasite eventually disappears from that area, as happened in North America, Europe, and parts of the Middle East. However, unless the parasite is eliminated from the whole world, it could re-establish if conditions revert to a combination that favors the parasite's reproduction. Furthermore, the cost per person of eliminating anopheles mosquitoes rises with decreasing population density, making it economically unfeasible in some areas. Prevention of malaria may be more cost-effective than treatment of
9504-451: The plenary hall, the tower consisted of a cylinder composed of several cuboids, and the amphitheater and helipad both resembled cones. The tower was built around a concrete core and it had no walls but glass windows, which allowed for maximum natural lighting. It had the largest halls in eastern and central Africa. A year prior in 1972, the World Bank approved funds for further expansion of
9612-540: The pre-colonial era, the people of modern Kenya mostly lived in villages amongst their tribes and cultural groups, where they had rulers within their communities rather than one singular government or leader. In 1898, Arthur Church was first and foremost commissioned to design the first town layout for the railway depot. It constituted two streets – Victoria Street and Station Street , ten avenues, staff quarters and an Indian commercial area. The railway arrived at Nairobi on 30 May 1899, and soon Nairobi replaced Machakos as
9720-451: The prevention of bites. As of 2023, there are two malaria vaccines , approved for use in children by the WHO: RTS,S and R21 . The presence of malaria in an area requires a combination of high human population density, high Anopheles mosquito population density and high rates of transmission from humans to mosquitoes and from mosquitoes to humans. If any of these is lowered sufficiently,
9828-513: The railway. Whitehouse, chief engineer of the railway, favoured the site as an ideal resting place due to its high elevation, temperate climate, adequate water supply and being situated before the steep ascent of the Limuru escarpments . His choice was however criticised by officials within the Protectorate government who felt the site was too flat, poorly drained and relatively infertile. During
9936-411: The richest (71%) and the poorest (53%) households. Malaria is usually confirmed by the microscopic examination of blood films or by antigen -based rapid diagnostic tests (RDT). Microscopy—i.e. examining Giemsa -stained blood with a light microscope —is the gold standard for malaria diagnosis. Microscopists typically examine both a "thick film" of blood, allowing them to scan many blood cells in
10044-437: The screening and monitoring of infection to officially eradicate malaria. Research findings have predominantly relied on chemical explanations to explain the differences in attractiveness among humans based on distinct odor profiles. The existence of volatile compounds, like fatty acids, and lactic acid is an essential reason on why some individuals are more appealing to mosquitos than others. Volatile compounds Kanika Khanna,
10152-563: The spleen. The blockage of the microvasculature causes symptoms such as those in placental malaria. Sequestered red blood cells can breach the blood–brain barrier and cause cerebral malaria. Due to the high levels of mortality and morbidity caused by malaria—especially the P. falciparum species—it has placed the greatest selective pressure on the human genome in recent history. Several genetic factors provide some resistance to it including sickle cell trait , thalassaemia traits, glucose-6-phosphate dehydrogenase deficiency , and
10260-413: The then Nairobi Airport (now Jomo Kenyatta International Airport ), including a new international and domestic passenger terminal building, the airport's first dedicated cargo and freight terminal, new taxiways, associated aprons, internal roads, car parks, police and fire stations, a State Pavilion, airfield and roadway lighting, fire hydrant system, water, electrical, telecommunications and sewage systems,
10368-498: The town moved. In the early 1900s, Bazaar Street (now Biashara Street) was completely rebuilt after an outbreak of plague and the burning of the original town. Between 1902 and 1910, the town's population rose from 5,000 to 16,000 and grew around administration and tourism, initially in the form of big game hunting . In 1907, Nairobi replaced Mombasa as the capital of the East Africa Protectorate. In 1919, Nairobi
10476-605: The trait's survival, the trait is preserved in malaria-prone regions because of the benefits provided by the heterozygous form. Liver dysfunction as a result of malaria is uncommon and usually only occurs in those with another liver condition such as viral hepatitis or chronic liver disease . The syndrome is sometimes called malarial hepatitis . While it has been considered a rare occurrence, malarial hepatopathy has seen an increase, particularly in Southeast Asia and India. Liver compromise in people with malaria correlates with
10584-502: The upmarket suburbs are situated to the west and north-central of Nairobi, where most European settlers resided during the colonial times AKA 'Ubabini'. These include Karen , Langata , Lavington , Gigiri , Muthaiga , Brookside, Spring Valley, Loresho, Kilimani , Kileleshwa, Hurlingham, Runda , Kitisuru , Nyari, Kyuna, Lower Kabete , Westlands , and Highridge , although Kangemi, Kawangware, and Dagoretti are lower income areas close to these affluent suburbs. The city's colonial past
10692-415: The urine with kidney failure may occur. Complications may include spontaneous bleeding, coagulopathy , and shock . Malaria during pregnancy can cause stillbirths , infant mortality , miscarriage , and low birth weight , particularly in P. falciparum infection, but also with P. vivax . Malaria is caused by infection with parasites in the genus Plasmodium . In humans, malaria
10800-424: The urine , retinal damage , and convulsions . The classic symptom of malaria is paroxysm —a cyclical occurrence of sudden coldness followed by shivering and then fever and sweating, occurring every two days ( tertian fever ) in P. vivax and P. ovale infections, and every three days ( quartan fever ) for P. malariae . P. falciparum infection can cause recurrent fever every 36–48 hours, or
10908-401: The vast majority of malaria deaths), P. vivax , and P. knowlesi (a simian malaria that spills over into thousands of people a year). P. ovale and P. malariae generally cause a milder form of malaria. Malaria is typically diagnosed by the microscopic examination of blood using blood films , or with antigen-based rapid diagnostic tests . Methods that use
11016-427: The world where malaria is common were protected by an ITN. That number increased to 20.3 million (18.5%) African children using ITNs in 2007, leaving 89.6 million children unprotected and to 68% African children using mosquito nets in 2015. The percentage of children sleeping under ITNs in sub-Saharan Africa increased from less than 40% in 2011 to over 50% in 2021. Most nets are impregnated with pyrethroids ,
11124-762: Was considered to have about 4 million residents. A large beautification project took place in the Central Business District, as the city prepared to host the 2006 Afri-Cities summit. Iconic buildings such as the Kenyatta International Conference Centre had their exteriors cleaned and repainted. Malaria Malaria is a mosquito-borne infectious disease that affects vertebrates and Anopheles mosquitoes. Human malaria causes symptoms that typically include fever , fatigue , vomiting , and headaches . In severe cases, it can cause jaundice , seizures , coma , or death . Symptoms usually begin 10 to 15 days after being bitten by an infected Anopheles mosquito . If not properly treated, people may have recurrences of
11232-525: Was declared to be a municipality. In 1921, Nairobi had 24,000 residents, of which 12,000 were native Africans. The next decade saw growth in native African communities in Nairobi, and they began to constitute a majority for the first time. This growth caused planning issues, described by Thorntorn White Archived 22 October 2020 at the Wayback Machine and his planning team as the "Nairobi Problem". In February 1926, colonial officer Eric Dutton passed through Nairobi on his way to Mount Kenya , and said of
11340-753: Was developed to reduce traffic congestion along Mombasa Road. Additionally, the Green Park Bus Terminal , part of efforts to improve public transport, began operations in 2021. In line with the Kenyan government's Affordable Housing Program , various housing developments are underway to accommodate the city's growing population. The city is situated at 1°09′S 36°39′E / 1.150°S 36.650°E / -1.150; 36.650 ( Nairobi, Kenya ) and 1°27′S 37°06′E / 1.450°S 37.100°E / -1.450; 37.100 ( Nairobi, Kenya ) and occupies 696 square kilometres (270 sq mi). Nairobi
11448-695: Was open to the public. The 28-storey building at the time was designed by the Norwegian architect Karl Henrik Nøstvik and Kenyan David Mutiso. It is the only building within the city with a helipad that is open to the public. Of the buildings built in the Seventies, the KICC was the most eco-friendly and most environmentally conscious structure; its main frame was constructed with locally available materials gravel, sand, cement and wood, and it had wide open spaces which allowed for natural aeration and natural lighting. Cuboids made up
11556-522: Was renamed Jomo Kenyatta International Airport in memory of its first president. The Giraffe Centre , an animal sanctuary on the southwestern outskirts of Nairobi, was opened in 1983. To this day, it breeds the endangered species of Rothschild's giraffe . The United States Embassy, then located in downtown Nairobi, was bombed in August 1998 by Al-Qaeda and the Egyptian Islamic Jihad , as one of
11664-403: Was sworn in as acting Nairobi Governor four days after the previous Nairobi Governor Mike Sonko was impeached and removed from office. At the time of Mutura's swearing in as acting Governor, which he will hold for at least 60 days, Nairobi did not have a Deputy Governor as well. Nairobi has seen several major infrastructure projects in recent years. The Nairobi Expressway , completed in 2022,
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