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Krembil Research Institute

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The Krembil Research Institute , formerly known as the Toronto Western Research Institute, is an academic medical research institute in Toronto. It is one of the largest research institutes in Canada focusing on human neurological disease .

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18-539: Krembil is one of the principal research institutes of the University Health Network and is the research institute of the Toronto Western Hospital . Krembil researches treatments for Alzheimer's disease , Parkinson's disease, epilepsy , stroke, brain tumours , concussions, spinal cord injuries , neuro-ophthalmologic and other ocular disorders, multiple sclerosis and autoimmune disorders . In

36-470: A public , non-profit or for-profit company or organization that provides two or more hospitals and other broad healthcare facilities and services. A hospital network may include hospitals in one or more regions within one or more states within one or more countries. A hospital network has one headquarter, usually within one of the regions served by the network facilities. (The terms hospital system and health care system are used more broadly to define

54-608: A neurosurgeon and neurophysiologist, was the first official director of the Krembil; his research focussed on therapeutic approaches to vascular brain injury . Peter St George-Hyslop MD, PhD, FRCPC, a neurologist and PhD geneticist, was the second full-time director of the Krembil; his research focussed on the genetic basis of neurodegenerative diseases such as Alzheimer's dementia. Krembil occupies 105,000 sq ft (9,800 m) at Toronto Western Hospital for basic science, clinical, imaging and epidemiological research. In 2011,

72-497: Is a list of hospital networks with a capacity of more than 2,500 beds. This is a list of hospital networks with at least 20,000 staff. The largest hospital networks headquartered in the United States are included in the table below. The name, headquarters location, number of hospitals, funding type and founding year are given for each network. There were 6,146 hospitals in the United States in 2020, of which 2,240 were managed by

90-558: Is a public research and teaching hospital network in Toronto , Ontario , Canada. It is affiliated with the University of Toronto , and is the largest health research organization in Canada, ranking first in Canada for total research funding. The network includes four hospitals – Toronto General Hospital , Toronto Western Hospital , Princess Margaret Cancer Centre – West Park Healthcare Centre,

108-503: Is also home to the Vision Science Research Program, a joint UHN/University of Toronto Program. This research is directed into the following areas: molecular genetics of blinding eye diseases with brain disorders; treatment and biophysics of glaucoma ; eye movement control mechanisms; neuronal damage ; retinal degeneration and diabetic retinopathy . Arthritis and associated rheumatological degenerative diseases are

126-511: Is led by infectious diseases specialist Andrew Morris , who joined as founding director at its inception in 2009. During the COVID-19 pandemic , UHN received a $ 323,981 grant from the Public Health Agency of Canada 's Immunization Partnership Fund to increase COVID-19 vaccine uptake among personal support workers and their patients. Hospital network A hospital network is

144-484: The Toronto Rehabilitation Institute , and The Michener Institute , a post-secondary institution granting diplomas and certificates in health sciences and leadership. In the 2019-2020 fiscal year, there were over 39,000 acute inpatient stays and close to 121,000 emergency department visits across the three acute care hospitals. Newsweek has consistently named UHN's Toronto General Hospital as among

162-658: The Krembil had emerged as one of the largest research institutes in Canada with a neuroscience emphasis. On November 13, 2015, the Krembil took on its current name from the Krembil family. In 2013, the Krembil Discovery Tower opened at Toronto Western. Krembil neuroscientists explore the function of the nervous system as they develop treatments for neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease, epilepsy, spinal cord injuries , cerebral ischemia (stroke), vascular brain malformations, aneurysms , brain tumours and pain disorders . The Krembil

180-553: The Krembil was home to 122 biomedical researchers, 206 technical/support staff and 157 research trainees, who collectively produced 515 peer-reviewed publications supported by more than $ 43,612,000 of external research funding. In 2013, Krembil expanded into an additional 325,000 sq ft (30,200 m) of space, spanning nine floors, in the Krembil Discovery Tower. The Tower space includes 150,000 sq ft (14,000 m) of "wet" laboratory bench space for Krembil basic science researchers. Krembil receives support from

198-859: The Romans. These hospitals were established to cater to "particular social groups marginalized by poverty, sickness, and age," according to historian of hospitals, Guenter Risse. In the late 20th century hospital networks were established to make delivery of healthcare more efficient and to share specialized medical services and physicians across the network. To avoid financial losses due to shrinking reimbursements and rising costs as well as improving quality of care and avoid duplication of services, hospitals may consolidate certain services at one hospital. However, patients may need to travel farther if those services are no longer offered at their local hospital. Hospital networks that do not have reliable sources may not be included; these are not necessarily complete lists. This

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216-760: The Toronto General/Toronto Western Hospital Foundation which is currently embarked upon a $ 200 million "Brain Campaign" to support neuroscience research at Krembil. The campaign had raised over $ 273 million as of January 2016. The Krembil has many strategic research alliances, nationally and internationally, to facilitate and enhance the delivery of its research mandate. Two of the strategic research alliances are: 43°39′12″N 79°24′20″W  /  43.65338°N 79.40563°W  / 43.65338; -79.40563 University Health Network University Health Network ( UHN )

234-754: The Toronto Hospital. In 1998, the Princess Margaret Cancer Centre joined, with the resulting institution named the University Health Network in 1999. The Toronto Rehabilitation Institute joined in 2011, facilitating rehabilitation services for patients as they transitioned out of acute care. All four hospitals are affiliated with the Faculty of Medicine at the University of Toronto and serve as teaching hospitals for resident physicians , nurses , and other healthcare professions. 2016 saw

252-601: The early 1980s, Toronto Western took on additional neurological and neurosurgical care responsibilities for the UHN group. In 1980, the Playfair Neuroscience Institute was created. In 1999, it was renamed the Toronto Western Research Institute. The Institute added research areas in ophthalmology , rheumatology and orthopaedics . By 2004, under the founding leadership of neurosurgeon C. Wallace,

270-522: The focus of the researchers in the musculoskeletal research program at the Krembil as part of the UHN Arthritis and Autoimmunity Research Centre. Their investigations are aimed at revealing the causes of, and generating therapies for, these autoimmune and orthopaedic ailments. In September 2021, Krembil took ownership of the World Community Grid from IBM . Christopher Wallace MD, MSc, FRCSC,

288-541: The integration of The Michener Institute into the UHN. The Michener Institute for Education was originally established in 1958 and is the first non-medical unit to join the UHN. On April 1, 2024, West Park Healthcare Centre joined the UHN. UHN and Sinai Health System jointly run the SHS-UHN Antimicrobial Stewardship Program, advocating for improved patient access to appropriate antibiotics while combating antimicrobial resistance . The program

306-526: The organization of people, institutions, and resources that deliver health care services to meet the health needs of a region or country.) Some of the earliest hospital networks were affiliated with charitable, religious organizations. The Catholic Church established a hospital network in Medieval Europe that was vastly improved from the merely reciprocal hospitality of the Greeks and family-based obligations of

324-465: The world's top hospitals, most recently ranking Toronto General as the world's 3rd best hospital in 2024, and first in Canada. The hospital was named Canada's top research hospital by Research Infosource from 2015 to 2022. A series of mergers over many years has resulted in the UHN in its current form. In 1986, the Toronto Western Hospital and the Toronto General Hospital merged to form

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