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113-555: Westphall, who is autistic , played an increased role in St. Elsewhere ' s final episode, " The Last One ", one interpretation of which is that the entire St. Elsewhere storyline exists only within Westphall's imagination. As characters from St. Elsewhere have appeared on other television shows and those shows' characters appeared on more shows, and so on, a "Tommy Westphall Universe" hypothesis (postulated by Dwayne McDuffie ) argues that

226-761: A computer -like screen , computer viruses , video chat , tanning beds , home treadmills , and more. In 1963, the time travel-themed Doctor Who premiered on BBC Television. The original series ran until 1989 and was revived in 2005. It has been extremely popular worldwide and has greatly influenced later TV science fiction. Other programs in the 1960s included The Outer Limits (1963–1965), Lost in Space (1965–1968), and The Prisoner (1967). Star Trek (the original series), created by Gene Roddenberry , premiered in 1966 on NBC Television and ran for three seasons. It combined elements of space opera and Space Western . Only mildly successful at first,

339-633: A hard hat . The following exchange occurs: Father: "Hi Pop, how you doing?" Grandfather: "Good. How was your day up on the building?" Father: "Well, we finally topped off the 22nd story. And I'm beat. How's he been? ( referring to Tommy ) He give you any trouble?" Grandfather: "He's been sitting there ever since you left this morning, just like he does every day. World of his own." Father: "I don't understand this autism thing, Pop. Here's my son, I talk to him, I don't even know if he can hear me. He sits there, all day long, in his own world, staring at that toy. What's he thinking about?" Tommy, who

452-452: A neurodevelopmental disorder , but the autism rights movement (and some researchers) see autistic people as part of humanity's natural neurodiversity . From this point of view, autistic people may also be diagnosed with a disability of some sort, but that disability may be rooted in the systemic structures of a society rather than in the person; thus, proponents argue that autistic people should be accommodated rather than cured. On

565-428: A space opera , went on to become a worldwide popular culture phenomenon , and the second-highest-grossing film series of all time. Since the 1980s, science fiction films , along with fantasy , horror , and superhero films, have dominated Hollywood's big-budget productions. Science fiction films often " cross-over " with other genres, including film noir ( Blade Runner - 1982), family film ( E.T.

678-602: A "level" system, which ranks how in need of support the patient is, level 1 being the mildest and level 3 the severest, while the ICD-11 system has two axes, intellectual impairment and language impairment, as these are seen as the most crucial factors. Autism is currently defined as a highly variable neurodevelopmental disorder that is generally thought to cover a broad and deep spectrum , manifesting very differently from one person to another. Some have high support needs, may be nonspeaking , and experience developmental delays; this

791-601: A 2002 blog post, as a reductio ad absurdum argument against making strong statements about fictional continuity based upon guest appearances. In a 2003 article published on BBC News Online, St. Elsewhere writer Tom Fontana was quoted as saying "Someone did the math once... and something like 90 percent of all [American] television took place in Tommy Westphall's mind. God love him." The St. Elsewhere characters Dr. Roxanne Turner ( Alfre Woodard ) and Dr. Victor Ehrlich ( Ed Begley Jr. ) appeared on Homicide: Life on

904-438: A broader medical condition or syndrome , representing about 25% of ASD cases. The causes of syndromic autism are often known, and monogenic disorders account for approximately 5% of these cases. Non-syndromic autism, also known as classic or idiopathic autism, represents the majority of cases, and its cause is typically polygenic and unknown. Autism has a strong genetic basis, although the genetics of autism are complex and it

1017-552: A genetic reason why males are diagnosed more often, such as the imprinted brain hypothesis and the extreme male brain theory . Science fiction Science fiction (sometimes shortened to SF or sci-fi ) is a genre of speculative fiction , which typically deals with imaginative and futuristic concepts such as advanced science and technology , space exploration , time travel , parallel universes , and extraterrestrial life . It often explores human responses to changes in science and technology. Science fiction

1130-535: A great and influential film. In 1954, Godzilla , directed by Ishirō Honda , began the kaiju subgenre of science fiction film, which feature large creatures of any form, usually attacking a major city or engaging other monsters in battle . 1968's 2001: A Space Odyssey , directed by Stanley Kubrick and based on the work of Arthur C. Clarke , rose above the mostly B-movie offerings up to that time both in scope and quality, and influenced later science fiction films. That same year, Planet of

1243-669: A journey to the Moon and how the Earth 's motion is seen from there. Kepler has been called the "father of science fiction". Following the 17th-century development of the novel as a literary form , Mary Shelley 's Frankenstein (1818) and The Last Man (1826) helped define the form of the science fiction novel. Brian Aldiss has argued that Frankenstein was the first work of science fiction. Edgar Allan Poe wrote several stories considered to be science fiction, including " The Unparalleled Adventure of One Hans Pfaall " (1835), which featured

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1356-648: A low demand for coordination that ameliorated many challenges associated with disruptive turns." Autistic interests, and thus conversational topics, seem to be largely driven by an intense interest in specific topics ( monotropism ). Historically, autistic children were said to be delayed in developing a theory of mind , and the empathizing–systemizing theory has argued that while autistic people have compassion ( affective empathy ) for others with similar presentation of symptoms, they have limited, though not necessarily absent, cognitive empathy . This may present as social naïvety, lower than average intuitive perception of

1469-575: A model of social patterns, and develop coping mechanisms, referred to as " masking ", which have recently been found to come with psychological costs and a higher increased risk of suicidality. ASD includes a wide variety of characteristics. Some of these include behavioral characteristics which widely range from slow development of social and learning skills to difficulties creating connections with other people. Autistic people may experience these challenges with forming connections due to anxiety or depression, which they are more likely to experience, and as

1582-923: A neurotypical bias in autism research, which has come to be scrutinized for "dehumanization, objectification, and stigmatization". Recent research has proposed that autistics' lack of readability and a neurotypical lack of effort to interpret atypical signals may cause a negative interaction loop, increasingly driving both groups apart into two distinct groups with different social interaction styles. Differences in verbal communication begin to be noticeable in childhood, as many autistic children develop language skills at an uneven pace. Verbal communication may be delayed or never develop ( nonverbal autism ), while reading ability may be present before school age ( hyperlexia ). Reduced joint attention seem to distinguish autistic from non-autistic infants. Infants may show delayed onset of babbling , unusual gestures, diminished responsiveness, and vocal patterns that are not synchronized with

1695-563: A person can depend on context, and may vary over time. While the DSM and ICD greatly influence each other, there are also differences. For example, Rett syndrome was included in ASD in the DSM-5, but in the ICD-11 it was excluded and placed in the chapter on Developmental Anomalies. The ICD and the DSM change over time, and there has been collaborative work toward a convergence of the two since 1980 (when DSM-III

1808-505: A person's ASD diagnosis did not influence their interest level. Thus, there has been a recent shift to acknowledge that autistic people may simply respond and behave differently than people without ASD. So far, research has identified two unconventional features by which autistic people create shared understanding ( intersubjectivity ): "a generous assumption of common ground that, when understood, led to rapid rapport, and, when not understood, resulted in potentially disruptive utterances; and

1921-637: A person's ability to understand and connect with others, as well as their adaptability to everyday situations, with its severity and support needs varying widely across the underlying spectrum . For example, some are nonverbal , while others have proficient spoken language. A formal diagnosis of ASD according to either the DSM-5 or the ICD-11 criteria requires not merely the presence of ASD symptoms, but symptoms that cause significant impairment in multiple domains of functioning, in addition to being atypical or excessive for

2034-547: A pervasive feature of the individual's functioning observable in all settings, although they may vary according to social, educational, or other context. Individuals along the spectrum exhibit a full range of intellectual functioning and language abilities. ICD-11 was produced by professionals from 55 countries out of the 90 involved and is the most widely used reference worldwide. The American Psychiatric Association 's Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition, Text Revision ( DSM-5-TR ), released in 2022,

2147-449: A previous Dr Pepper ad campaign references Bob Newhart's psychiatrist from The Bob Newhart Show appearing in "The Last Newhart ". Autism spectrum Autism , or autism spectrum disorder ( ASD ), is a neurodevelopmental disorder characterized by repetitive, restricted, and inflexible patterns of behavior, interests, and activities, as well as deficits in social interaction and social communication. Autism generally affects

2260-628: A result isolate themselves. Other behavioral characteristics include abnormal responses to sensations (such as sights, sounds, touch, taste and smell) and problems keeping a consistent speech rhythm. The latter problem influences social skills, leading to potential problems in understanding for interlocutors. Autistic people's behavioral characteristics typically influence development, language, and social competence. Their behavioral characteristics can be observed as perceptual disturbances, disturbances of development rate, relating, speech and language, and motility. The second core symptom of autism spectrum

2373-423: A set of closely related and overlapping diagnoses such as Asperger syndrome and the syndrome formerly known as Kanner syndrome . This created unclear boundaries between the terms, so for the DSM-5 and ICD-11, a spectrum approach was taken. The new system is also more restrictive, meaning fewer people qualify for diagnosis. The DSM-5 and ICD-11 use different categorization tools to define this spectrum. DSM-5 uses

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2486-512: A significant amount of fictional episodic television exists within a fictional universe imagined by Tommy Westphall. In the last episode's final two scenes, Donald Westphall – having just returned to St. Eligius – is shown in Dr. Auschlander's office pondering the recent death from stroke of his colleague and mentor. With the aria "Chi il bel sogno di Doretta" (Doretta's Beautiful Dream) from Puccini's opera La Rondine playing, Tommy Westphall enters

2599-491: A small effect, and some of which are rare and have a large effect. The most common gene disrupted with large effect rare variants appeared to be CHD8 , but less than 0.5% of autistic people have such a mutation. The gene CHD8 encodes the protein chromodomain helicase DNA binding protein 8, which is a chromatin regulator enzyme that is essential during fetal development. CHD8 is an adenosine triphosphate (ATP)–dependent enzyme. The protein contains an Snf2 helicase domain that

2712-418: A society (on Earth or another planet) that has developed in wholly different ways from our own." There is a tendency among science fiction enthusiasts as their own arbiter in deciding what exactly constitutes science fiction. David Seed says it may be more useful to talk about science fiction as the intersection of other more concrete subgenres. Damon Knight summed up the difficulty, saying "Science fiction

2825-399: A steady course without remission (different developmental timelines are described in more detail below). Autistic people may be severely impaired in some respects but average, or even superior, in others. Clinicians consider assessment for ASD when a patient shows: These features are typically assessed with the following, when appropriate: There are many signs associated with autism;

2938-448: A substantial fraction of autism cases may be traceable to genetic causes that are highly heritable but not inherited: that is, the mutation that causes the autism is not present in the parental genome. As of 2018 , understanding of genetic risk factors had shifted from a focus on a few alleles to an understanding that genetic involvement in ASD is probably diffuse, depending on a large number of variants, some of which are common and have

3051-421: A tendency to be associated with sedation and weight gain . Melatonin supplementation has been shown to improve insomnia related to autism. Stimulant therapy may improve mental processing speed when there is comorbid ADHD. Before the DSM-5 (2013) and ICD-11 (2022) diagnostic manuals were adopted, ASD was found under the diagnostic category pervasive developmental disorder . The previous system relied on

3164-495: A total estimated readership of at least 1 million), making it the world's most popular science fiction periodical . In 1984, William Gibson 's first novel, Neuromancer , helped popularize cyberpunk and the word " cyberspace ", a term he originally coined in his 1982 short story Burning Chrome . In 1986, Shards of Honor by Lois McMaster Bujold began her Vorkosigan Saga . 1992's Snow Crash by Neal Stephenson predicted immense social upheaval due to

3277-493: A trend of increasing prevalence over time. This increasing prevalence has reinforced the myth perpetuated by anti-vaccine activists that autism is caused by vaccines . Boys are also significantly far more frequently diagnosed than girls. There is no known cure for autism, and some advocates dispute the need to find one. Early intervention services based on applied behavior analysis (ABA) aim to teach children self-care, social and communicative skills. Guidelines from

3390-516: A trip to the Moon . Jules Verne was noted for his attention to detail and scientific accuracy, especially in Twenty Thousand Leagues Under the Seas (1870). In 1887, the novel El anacronópete by Spanish author Enrique Gaspar y Rimbau introduced the first time machine . An early French/Belgian science fiction writer was J.-H. Rosny aîné (1856–1940). Rosny's masterpiece

3503-575: A very palatable form... New adventures pictured for us in the scientifiction of today are not at all impossible of realization tomorrow... Many great science stories destined to be of historical interest are still to be written... Posterity will point to them as having blazed a new trail, not only in literature and fiction, but progress as well. In 1928, E. E. "Doc" Smith 's first published work, The Skylark of Space , written in collaboration with Lee Hawkins Garby , appeared in Amazing Stories . It

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3616-537: A view of the eponymous building, which fades into a model of the same, in a snow globe, observed by NBC president Kenneth Parcell roughly a century into the future, as flying cars whiz past his window. The entire series is revealed to have been based on the stories Liz Lemon told her great-granddaughter, a future television writer, and as remembered by the more-or-less immortal Parcell. Dr Pepper includes an homage to Tommy Westphall's snowglobe in its 2021 advertising campaign. The commercial titled "Off Season" features

3729-623: A world of harmony and conformity within a united totalitarian state . It influenced the emergence of dystopia as a literary genre . In 1926, Hugo Gernsback published the first American science fiction magazine , Amazing Stories . In its first issue he wrote: By 'scientifiction' I mean the Jules Verne, H. G. Wells and Edgar Allan Poe type of story—a charming romance intermingled with scientific fact and prophetic vision... Not only do these amazing tales make tremendously interesting reading—they are always instructive. They supply knowledge... in

3842-470: Is Les Navigateurs de l'Infini ( The Navigators of Infinity ) (1925) in which the word astronaut, "astronautique", was used for the first time. Many critics consider H. G. Wells one of science fiction's most important authors, or even "the Shakespeare of science fiction". His works include The Time Machine (1895), The Island of Doctor Moreau (1896), The Invisible Man (1897), and The War of

3955-708: Is a pattern of restricted and repetitive behaviors, activities, and interests. In order to be diagnosed with ASD under the DSM-5-TR, a person must have at least two of the following behaviors: Autistic people can display many forms of repetitive or restricted behavior, which the Repetitive Behavior Scale-Revised (RBS-R) categorizes as follows. Self-injurious behaviors are relatively common in autistic people, and can include head-banging, self-cutting, self-biting, and hair-pulling. Some of these can result in serious injury or death. Following are theories about

4068-734: Is acquired during childhood. Autistic people display atypical nonverbal behaviors or show differences in nonverbal communication . They may make infrequent eye contact , even when called by name, or avoid it altogether. This may be due to the high amount of sensory input received when making eye contact. Autistic people often recognize fewer emotions and their meaning from others' facial expressions, and may not respond with facial expressions expected by their non-autistic peers. Temple Grandin , an autistic woman involved in autism activism, described her inability to understand neurotypicals ' social communication as leaving her feeling "like an anthropologist on Mars". Autistic people struggle to understand

4181-661: Is bidirectional, research on communication difficulties has since also begun to study non-autistic behavior, with researcher Catherine Crompton writing in 2020 that non-autistic people "struggle to identify autistic mental states, identify autistic facial expressions, overestimate autistic egocentricity, and are less willing to socially interact with autistic people. Thus, although non-autistic people are generally characterised as socially skilled, these skills may not be functional, or effectively applied, when interacting with autistic people." Any previously observed communication deficits of autistic people may thus have been constructed through

4294-590: Is heritable. After an older child is diagnosed with ASD, 7% to 20% of subsequent children are likely to be as well. If parents have one autistic child, they have a 2% to 8% chance of having a second child who is autistic. If the autistic child is an identical twin, the other will be affected 36% to 95% of the time. A fraternal twin is affected up to 31% of the time. The large number of autistic people with unaffected family members may result from spontaneous structural variation , such as deletions , duplications or inversions in genetic material during meiosis . Hence,

4407-420: Is lowered activity in the fusiform face area of the brain, which is associated with impaired perception of people versus objects. It has been proposed to classify autism using genetics as well as behavior. Autism spectrum disorder (ASD) can be classified into two categories: "syndromic autism" and "non-syndromic autism". Syndromic autism refers to cases where ASD is one of the characteristics associated with

4520-522: Is more likely with other co-existing diagnoses. Others have relatively low support needs; they may have more typical speech-language and intellectual skills but atypical social/conversation skills, narrowly focused interests , and wordy, pedantic communication. They may still require significant support in some areas of their lives. The spectrum model should not be understood as a continuum running from mild to severe, but instead means that autism can present very differently in each person. How it presents in

4633-619: Is often called the first great space opera . The same year, Philip Francis Nowlan 's original Buck Rogers story, Armageddon 2419 , also appeared in Amazing Stories . This was followed by a Buck Rogers comic strip , the first serious science fiction comic . Last and First Men: A Story of the Near and Far Future is a " future history " science fiction novel written in 1930 by the British author Olaf Stapledon . A work of unprecedented scale in

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4746-503: Is one of the most influential examples of social science fiction , feminist science fiction , and anthropological science fiction . In 1979, Science Fiction World began publication in the People's Republic of China . It dominates the Chinese science fiction magazine market , at one time claiming a circulation of 300,000 copies per issue and an estimated 3–5 readers per copy (giving it

4859-711: Is possible to identify general factors, but much more difficult to pinpoint specific ones. Given the current state of knowledge, prediction can only be of a global nature and so requires the use of general markers. Research into causes has been hampered by the inability to identify biologically meaningful subgroups within the autistic population and by the traditional boundaries between the disciplines of psychiatry , psychology , neurology and pediatrics . Newer technologies such as fMRI and diffusion tensor imaging can help identify biologically relevant phenotypes (observable traits) that can be viewed on brain scans , to help further neurogenetic studies of autism; one example

4972-560: Is related to fantasy , horror , and superhero fiction and contains many subgenres . Its exact definition has long been disputed among authors, critics, scholars, and readers. Subgenres include hard science fiction , which emphasizes scientific accuracy, and soft science fiction , focusing on social sciences. Other notable subgenres are cyberpunk , which explores the interface between technology and society, and climate fiction , addressing environmental issues. Precedents for science fiction are argued to exist as far back as antiquity, but

5085-422: Is responsible for the hydrolysis of ATP to adenosine diphosphate (ADP). CHD8 encodes a DNA helicase that functions as a repressor of transcription, remodeling chromatin structure by altering the position of nucleosomes. CHD8 negatively regulates Wnt signaling . Wnt signaling is important in the vertebrate early development and morphogenesis. It is believed that CHD8 also recruits the linker histone H1 and causes

5198-490: Is shaking a snow globe , is told by his father to come and wash his hands. As they leave the living room, Tommy's father places the snow globe upon a television set. The camera slowly zooms in on the snow globe, which is revealed to contain a replica of St. Eligius hospital inside of it. The foremost interpretation of this scene is that the entire series of events in St. Elsewhere were dreamt by Tommy Westphall, and thus, products of his imagination. According to Lindsey Freeman,

5311-710: Is the current version of the DSM. It is the predominant mental health diagnostic system used in the United States and Canada, and is often used in Anglophone countries. Its fifth edition, DSM-5 , released in May 2013, was the first to define ASD as a single diagnosis, which is still the case in the DSM-5-TR. ASD encompasses previous diagnoses, including the four traditional diagnoses of autism— classic autism , Asperger syndrome , childhood disintegrative disorder , and pervasive developmental disorder not otherwise specified (PDD-NOS)—and

5424-399: Is unclear whether ASD is explained more by rare mutations with major effects, or by rare multi-gene interactions of common genetic variants. Complexity arises due to interactions among multiple genes, the environment, and epigenetic factors which do not change DNA sequencing but are heritable and influence gene expression . Many genes have been associated with autism through sequencing

5537-537: Is what we point to when we say it." Forrest J Ackerman has been credited with first using the term "sci-fi" (analogous to the then-trendy " hi-fi ") in about 1954. The first known use in print was a description of Donovan's Brain by movie critic Jesse Zunser in January 1954. As science fiction entered popular culture , writers and fans active in the field came to associate the term with low-budget, low-tech " B-movies " and with low-quality pulp science fiction . By

5650-536: The Golden Age of Science Fiction . Science fiction has been called the "literature of ideas ", and continues to evolve, incorporating diverse voices and themes, influencing not just literature but film, TV, and culture at large. Besides providing entertainment it can also criticize present-day society and explore alternatives, and inspiration a " sense of wonder ". According to Isaac Asimov , "Science fiction can be defined as that branch of literature which deals with

5763-772: The Centres for Disease Control (CDC), NICE, and European Society for Child & Adolescent Psychiatry endorse the use of ABA as it reduces symptoms that impair daily functioning and quality of life, although NICE acknowledges that ABA does not meet the highest level of evidence quality. Additionally, some in the autism rights movement oppose its application due to a perception that it emphasises normalisation. Speech and occupational therapy , as well as augmentative and alternative modes of communication , are effective adjunctive therapies . At present, no medication has been shown to reduce ASD's "core symptoms". Some atypical antipsychotics can alleviate comorbid irritability, though with

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5876-486: The Review Journal of Autism and Developmental Disorders published a systematic review of 21 studies investigating associations between ASD, problematic internet use, and gaming disorder where the majority of the studies found positive associations between the disorders. Exactly what causes autism remains unknown. It was long mostly presumed that there is a common cause at the genetic, cognitive, and neural levels for

5989-477: The Russian writer and paleontologist Ivan Yefremov presented a view of a future interstellar communist civilization and is considered one of the most important Soviet science fiction novels. In 1959, Robert A. Heinlein 's Starship Troopers marked a departure from his earlier juvenile stories and novels. It is one of the first and most influential examples of military science fiction , and introduced

6102-447: The information revolution . In 2007, Liu Cixin 's novel, The Three-Body Problem , was published in China. It was translated into English by Ken Liu and published by Tor Books in 2014, and won the 2015 Hugo Award for Best Novel , making Liu the first Asian writer to win the award. Emerging themes in late 20th and early 21st century science fiction include environmental issues ,

6215-462: The science fiction program The X-Files and the Law & Order franchise (due to various crossovers with characters from Homicide , in particular Det. John Munch ). Law & Order creator Dick Wolf is close friends with Fontana and frequently crossed Homicide characters over into his own series. There are other possible interpretations of Tommy's "vision" which may suggest something other than

6328-400: The 1970s, critics within the field, such as Damon Knight and Terry Carr , were using "sci fi" to distinguish hack-work from serious science fiction. Peter Nicholls writes that "SF" (or "sf") is "the preferred abbreviation within the community of sf writers and readers." Robert Heinlein found even "science fiction" insufficient for certain types of works in this genre, and suggested

6441-550: The Apes (the original), directed by Franklin J. Schaffner and based on the 1963 French novel La Planète des Singes by Pierre Boulle , was released to popular and critical acclaim, its vivid depiction of a post-apocalyptic world in which intelligent apes dominate humans . In 1977, George Lucas began the Star Wars film series with the film now identified as " Star Wars: Episode IV – A New Hope . " The series, often called

6554-452: The DSM-5, the DSM separated social deficits and communication deficits into two domains. Further, the DSM-5 changed to an onset age in the early developmental period, with a note that symptoms may manifest later when social demands exceed capabilities, rather than the previous, more restricted three years of age. These changes remain in the DSM-5-TR. For many autistic people, characteristics first appear during infancy or childhood and follow

6667-575: The Extra-Terrestrial - 1983), war ( Enemy Mine - 1985), comedy ( Spaceballs - 1987, Galaxy Quest - 1999), animation ( WALL-E – 2008, Big Hero 6 – 2014), Western ( Serenity – 2005), action ( Edge of Tomorrow – 2014, The Matrix – 1999), adventure ( Jupiter Ascending – 2015, Interstellar – 2014), mystery ( Minority Report – 2002), thriller ( Ex Machina – 2014), drama ( Melancholia – 2011, Predestination – 2014), and romance ( Eternal Sunshine of

6780-457: The Spotless Mind – 2004, Her – 2013). Science fiction and television have consistently been in a close relationship. Television or television-like technologies frequently appeared in science fiction long before television itself became widely available in the late 1940s and early 1950s. The first known science fiction television program was a thirty-five-minute adapted excerpt of

6893-548: The States and Empires of the Moon (1657) and The States and Empires of the Sun (1662), Margaret Cavendish 's " The Blazing World " (1666), Jonathan Swift 's Gulliver's Travels (1726), Ludvig Holberg 's Nicolai Klimii Iter Subterraneum (1741) and Voltaire 's Micromégas (1752). Isaac Asimov and Carl Sagan considered Somnium the first science fiction story; it depicts

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7006-525: The Street . Fontana was the executive producer and showrunner for Homicide for the entirety of its seven-year run. Proponents of the Tommy Westphall Universe argue that because of this fictional crossover, the two series exist within the same fictional universe, and within Tommy Westphall's mind because of the final episode of St. Elsewhere ; by extension this hypothesis can be extended to include

7119-510: The Worlds (1898). His science fiction imagined alien invasion , biological engineering , invisibility , and time travel . In his non-fiction futurologist works he predicted the advent of airplanes , military tanks , nuclear weapons , satellite television , space travel , and something resembling the World Wide Web . Edgar Rice Burroughs 's A Princess of Mars , published in 1912,

7232-489: The appearance of a person or event in a dream does not mean the person or event cannot exist in real life. If a person dreams about visiting London and meeting Gordon Brown , it does not follow that because the city of London and Gordon Brown appeared in a dream, they do not exist in real life. Specific to the Westphall Hypothesis, even if we accept that St. Elsewhere is Westphall's dream, it does not imply that all of

7345-525: The art department create a replica of Tommy Westphall's snowglobe, which Wheatley placed in the TARDIS set as a reference to the hypothesis. NewsRadio episode "Daydream" (season 3 episode 7) ends with Jimmy James staring into a snow globe that appears to contain a miniature version of the WNYX office, thus seeming to indicate that Jimmy James has imagined the entire episode. The final scene of 30 Rock opens with

7458-516: The caregiver. In the second and third years, autistic children may have less frequent and less diverse babbling, consonants, words, and word combinations; their gestures are less often integrated with words. Autistic children are less likely to make requests or share experiences and more likely to simply repeat others' words ( echolalia ). The CDC estimated in 2015 that around 40% of autistic children do not speak at all. Autistic adults' verbal communication skills largely depend on when and how well speech

7571-464: The cast of the mock sitcom " Fansville " discussing their purpose after the conclusion of the college football season. After the "Fansville" characters exchange meta-humorous existential comments, the camera pans out to show that the characters in fact exist in a snowglobe sitting on Larry Culpepper's desk. Therefore, the commercial also does homage to the Newhart finale, as Larry Culpepper's presence from

7684-417: The cause of self-injurious behavior in children with developmental delay, including autistic children: The suicide rate for verbal autistics is nine times that of the general population. Studies have supported the common belief that autistic people become exhausted or burnt out in some situations. Autistic people may have symptoms that do not contribute to the official diagnosis, but that can affect

7797-439: The characters on the show exist only in his mind. Therefore, appearances from St. Elsewhere characters on other shows are not sufficient to indicate that those shows exist only in Westphall's dream. The notion that appearances by the same character in two or more series tie those series together in the same fictional universe is also problematic. Weatherson, in his sixth objection, offers the example of Michael Bloomberg playing

7910-413: The concept of powered armor exoskeletons . The German space opera series Perry Rhodan , written by various authors, started in 1961 with an account of the first Moon landing and has since expanded in space to multiple universes , and in time by billions of years. It has become the most popular science fiction book series of all time. In the 1960s and 1970s, New Wave science fiction

8023-461: The contrary, other scientists argue that ASD impairs functioning in many ways that are inherent to the disorder itself and unrelated to society. The neurodiversity perspective has led to significant controversy among those who are autistic and advocates, practitioners, and charities. The precise causes of autism are unknown in most individual cases. Research shows that the disorder is highly heritable and polygenic, and neurobiological risks from

8136-506: The creation of microrobots and micromachinery , nanotechnology , smartdust , virtual reality , and artificial intelligence (including swarm intelligence ), as well as developing the ideas of "necroevolution" and the creation of artificial worlds. In 1965, Dune by Frank Herbert featured a much more complex and detailed imagined future society than had previously in most science fiction. In 1967 Anne McCaffrey began her Dragonriders of Pern science fantasy series. Two of

8249-513: The current disorder-focused spectrum model deconstruct autism into at least two separate phenomena: (1) a non-pathological spectrum of behavioral traits in the population, and (2) the neuropathological burden of rare genetic mutations and environmental risk factors potentially leading to neurodevelopmental and psychological disorders, (3) governed by an individual's cognitive ability to compensate. The World Health Organization 's International Classification of Diseases (11th revision), ICD-11 ,

8362-400: The development of the autism spectrum, but it cannot be guaranteed that they are determinants for the development. ASD may be under-diagnosed in women and girls due to an assumption that it is primarily a male condition, but genetic phenomena such as imprinting and X linkage have the ability to raise the frequency and severity of conditions in males, and theories have been put forward for

8475-472: The devoted aficionado or fan—has a hard time trying to explain what science fiction is," and the lack of a "full satisfactory definition" is because "there are no easily delineated limits to science fiction." Another definition comes from The Literature Book by DK and is, "scenarios that are at the time of writing technologically impossible, extrapolating from present-day science...[,]...or that deal with some form of speculative science-based conceit, such as

8588-400: The entire series being his dream. For instance, it may be the other way around, and the snow globe scene may itself be the dream. Brian Weatherson , professor of philosophy at Cornell University, wrote a piece, "Six Objections to the Westphall Hypothesis", which challenges the logical, factual, and philosophical basis for the existence of the "universe". Weatherson's fifth objection holds that

8701-449: The environment are also relevant. Autism frequently co-occurs with attention deficit hyperactivity disorder (ADHD), epilepsy and intellectual disability , and research indicates that autistic people have significantly higher rates of LGBTQ+ identities and feelings than the general population. Disagreements persist about what should be included as part of the diagnosis, whether there are meaningful subtypes or stages of autism, and

8814-439: The episodes, ran from 1959 to 1964. It featured fantasy , suspense , and horror as well as science fiction, with each episode being a complete story. Critics have ranked it as one of the best TV programs of any genre . The animated series The Jetsons , while intended as comedy and only running for one season (1962–1963), predicted many inventions now in common use: flat-screen televisions , newspapers on

8927-682: The exposure starts at a younger age. In April 2021, Research in Autism Spectrum Disorders published a systematic review of 12 studies of video game addiction in ASD subjects that found that children, adolescents, and adults with ASD are at greater risk of video game addiction than those without ASD, and that the data from the studies suggested that internal and external factors (sex, attention and oppositional behavior problems, social aspects, access and time spent playing video games, parental rules, and game genre) were significant predictors of video game addiction in ASD subjects. In March 2022,

9040-743: The first science fiction novel . Some of the stories from The Arabian Nights , along with the 10th-century The Tale of the Bamboo Cutter and Ibn al-Nafis 's 13th-century Theologus Autodidactus , are also argued to contain elements of science fiction. Written during the Scientific Revolution and later the Age of Enlightenment are considered true science-fantasy books. Francis Bacon 's New Atlantis (1627), Johannes Kepler 's Somnium (1634), Athanasius Kircher 's Itinerarium extaticum (1656), Cyrano de Bergerac 's Comical History of

9153-562: The genomes of affected people and their parents. But most of the mutations that increase autism risk have not been identified. Typically, autism cannot be traced to a Mendelian (single-gene) mutation or to a single chromosome abnormality , and none of the genetic syndromes associated with ASD have been shown to selectively cause ASD. Numerous genes have been found, with only small effects attributable to any particular gene. Most loci individually explain less than 1% of cases of autism. As of 2018 , it appeared that between 74% and 93% of ASD risk

9266-480: The genre, it describes the history of humanity from the present onwards across two billion years. In 1937, John W. Campbell became editor of Astounding Science Fiction , an event that is sometimes considered the beginning of the Golden Age of Science Fiction , which was characterized by stories celebrating scientific achievement and progress . The "Golden Age" is often said to have ended in 1946, but sometimes

9379-472: The implications of the Internet and the expanding information universe, questions about biotechnology , nanotechnology , and post-scarcity societies . Recent trends and subgenres include steampunk , biopunk , and mundane science fiction . The first, or at least one of the first, recorded science fiction film is 1902's A Trip to the Moon , directed by French filmmaker Georges Méliès . It

9492-458: The individual's age and sociocultural context. Common signs of ASD include difficulty with social interaction and verbal and nonverbal communication , along with perseverative interests , stereotypic body movements , rigid routines, and hyper- or hypo-reactivity to sensory input . The World Health Organization (WHO), UK National Institute for Health and Care Excellence (NICE), and American Psychological Association classify autism as

9605-410: The individual's age and sociocultural context. The onset of the disorder occurs during the developmental period, typically in early childhood, but symptoms may not become fully manifest until later, when social demands exceed limited capacities. Deficits are sufficiently severe to cause impairment in personal, family, social, educational, occupational or other important areas of functioning and are usually

9718-815: The interpersonal relationship difficulties between autistic people and their non-autistic counterparts and how to solve them through teaching neurotypical social skills, but newer research has also evaluated what autistic people want from friendships, such as a sense of belonging and good mental health. Children with ASD are more frequently involved in bullying situations than their non-autistic peers, and predominantly experience bullying as victims rather than perpetrators or victim-perpetrators, especially after controlling for comorbid psychopathology. Prioritizing dependability and intimacy in friendships during adolescence, coupled with lowered friendship quantity and quality, often lead to increased loneliness in autistic people. As they progress through life, autistic people observe and form

9831-415: The late 1940s and the 1950s are included. In 1942, Isaac Asimov started his Foundation series , which chronicles the rise and fall of galactic empires and introduced psychohistory . The series was later awarded a one-time Hugo Award for "Best All-Time Series". Theodore Sturgeon 's More Than Human (1953) explored possible future human evolution . In 1957, Andromeda: A Space-Age Tale by

9944-456: The modern genre primarily arose in the 19th and early 20th centuries when popular writers began looking to technological progress and speculation. Mary Shelley 's Frankenstein , written in 1818, is often credited as the first true science fiction novel . Jules Verne and H.G. Wells are pivotal figures in the genre's development. In the 20th century, expanded with the introduction of space operas , dystopian literature, pulp magazines , and

10057-422: The narrative framing of Tommy's imagination as within a snow globe occurs because, as an " oneiric and mnemonic gadget", a snow globe "often finds itself as a companion piece to the dream sequences found in television and movies". He adds that, "while a controversial and maddening ending for some loyal viewers, the final episode of St. Elsewhere illustrates the rich and often blurred boundaries in how we experience

10170-472: The novellas included in the first novel, Dragonflight , made McCaffrey the first woman to win a Hugo or Nebula Award . In 1968, Philip K. Dick 's Do Androids Dream of Electric Sheep? was published. It is the literary source of the Blade Runner movie franchise . In 1969, The Left Hand of Darkness by Ursula K. Le Guin was set on a planet in which the inhabitants have no fixed gender . It

10283-412: The office and runs to the window, where he looks at the snow falling outside St. Eligius. An exterior camera shot of the hospital cuts to Tommy Westphall sitting in the living room of an apartment building alongside his grandfather, now being portrayed by Norman Lloyd (aka "Daniel Auschlander"). Tommy's father, still being portrayed by Ed Flanders (aka "Donald Westphall") arrives at the apartment wearing

10396-443: The other hand, genes controlling expression of glial and immune cells in the brain, e.g. astrocytes and microglia , respectively, are over-expressed, which correlates with increased number of glial and immune cells found in postmortem ASD brains. Some genes under investigation in ASD pathophysiology are those that affect the mTOR signaling pathway, which supports cell growth and survival. All these genetic variants contribute to

10509-572: The person or the family. In September 2018, the Review Journal of Autism and Developmental Disorders published a systematic review of 47 studies published from 2005 to 2016 that concluded that associations between autism spectrum disorder (ASD) and screen time was inconclusive. In May 2019, the Journal of Developmental and Behavioral Pediatrics published a systematic review of 16 studies that found that children and adolescents with ASD are exposed to more screen time than typically developing peers and that

10622-603: The play RUR , written by the Czech playwright Karel Čapek , broadcast live from the BBC's Alexandra Palace studios on 11 February 1938. The first popular science fiction program on American television was the children's adventure serial Captain Video and His Video Rangers , which ran from June 1949 to April 1955. The Twilight Zone (the original series), produced and narrated by Rod Serling , who also wrote or co-wrote most of

10735-438: The presence of other disorders or factors that likely contribute to the symptoms, other neurodevelopmental or mental disorders, intellectual disability, or language impairment). The symptom domains are (a) social communication and (b) restricted, repetitive behaviors, and there is the option of specifying a separate severity—the negative effect of the symptoms on the person—for each domain, rather than just overall severity. Before

10848-1396: The presentation varies widely: The broader autism phenotype describes people who may not have ASD but do have autistic traits , such as abnormalities in eye contact and stimming . According to the medical model, autistic people experience social communications impairments . Until 2013, deficits in social function and communication were considered two separate symptom domains. The current social communication domain criteria for autism diagnosis require people to have deficits across three social skills: social-emotional reciprocity, nonverbal communication, and developing and sustaining relationships. A deficit-based view predicts that autistic–autistic interaction would be less effective than autistic–non-autistic interactions or even non-functional. But recent research has found that autistic–autistic interactions are as effective in information transfer as interactions between non-autistics are, and that communication breaks down only between autistics and non-autistics. Also contrary to social cognitive deficit interpretations, recent (2019) research recorded similar social cognitive performances in autistic and non-autistic adults, with both of them rating autistic individuals less favorably than non-autistic individuals; however, autistic individuals showed more interest in engaging with autistic people than non-autistic people did, and learning of

10961-419: The range of diagnoses that included the word "autism". Rather than distinguishing among these diagnoses, the DSM-5 and DSM-5-TR adopt a dimensional approach with one diagnostic category for disorders that fall under the autism spectrum umbrella. Within that category, the DSM-5 and the DSM include a framework that differentiates each person by dimensions of symptom severity, as well as by associated features (i.e.,

11074-468: The reaction of human beings to changes in science and technology ." Robert A. Heinlein wrote that "A handy short definition of almost all science fiction might read: realistic speculation about possible future events, based solidly on adequate knowledge of the real world, past and present, and on a thorough understanding of the nature and significance of the scientific method ." American science fiction author and editor Lester del Rey wrote, "Even

11187-917: The regulation of long non-coding RNAs (lncRNAs), and the regulation of X chromosome inactivation (XCI) initiation, via regulation of Xist long non-coding RNA, the master regulator of XCI, though competitive binding to Xist regulatory regions. Some ASD is associated with clearly genetic conditions, like fragile X syndrome , but only around 2% of autistic people have fragile X. Hypotheses from evolutionary psychiatry suggest that these genes persist because they are linked to human inventiveness, intelligence or systemising. Current research suggests that genes that increase susceptibility to ASD are ones that control protein synthesis in neuronal cells in response to cell needs, activity and adhesion of neuronal cells, synapse formation and remodeling, and excitatory to inhibitory neurotransmitter balance. Therefore, although up to 1,000 different genes are thought to increase

11300-772: The repression of β-catenin and p53 target genes. The importance of CHD8 can be observed in studies where CHD8-knockout mice died after 5.5 embryonic days because of widespread p53-induced apoptosis. Some studies have determined the role of CHD8 in autism spectrum disorder (ASD). CHD8 expression significantly increases during human mid-fetal development. The chromatin remodeling activity and its interaction with transcriptional regulators have shown to play an important role in ASD aetiology . The developing mammalian brain has conserved CHD8 target regions that are associated with ASD risk genes. The knockdown of CHD8 in human neural stem cells results in dysregulation of ASD risk genes that are targeted by CHD8. Recently CHD8 has been associated with

11413-448: The risk of ASD, all of them eventually affect normal neural development and connectivity between different functional areas of the brain in a similar manner that is characteristic of an ASD brain. Some of these genes are known to modulate production of the GABA neurotransmitter, the nervous system's main inhibitory neurotransmitter. These GABA-related genes are under-expressed in an ASD brain. On

11526-445: The role of New York City Mayor both on Law & Order and in real life, which, if one accepts the logic of the hypothesis, indicates that real life is in the head of Tommy Westphall. Thus, it does not follow that because one person, place, or thing is present in two or more works of fiction that those works are necessarily related. When directing episodes for the eighth series of the revived Doctor Who in 2014, Ben Wheatley had

11639-409: The significance of autism-associated traits in the wider population. The combination of broader criteria, increased awareness, and the potential increase of actual prevalence, has led to considerably increased estimates of autism prevalence since the 1990s. The WHO estimates about 1 in 100 children had autism between 2012 and 2021, as that was the average estimate in studies during that period, with

11752-546: The social and non-social components of ASD's symptoms, described as a triad in the classic autism criteria. But it is increasingly suspected that autism is instead a complex disorder whose core aspects have distinct causes that often cooccur. It is unlikely that ASD has a single cause; many risk factors identified in the research literature may contribute to ASD. These include genetics, prenatal and perinatal factors (meaning factors during pregnancy or very early infancy), neuroanatomical abnormalities, and environmental factors. It

11865-523: The social context and subtext of neurotypical conversational or printed situations, and form different conclusions about the content. Autistic people may not control the volume of their voice in different social settings. At least half of autistic children have atypical prosody . What may look like self-involvement or indifference to non-autistic people stems from autistic differences in recognizing how other people have their own personalities, perspectives, and interests. Most published research focuses on

11978-515: The term speculative fiction to be used instead for those that are more "serious" or "thoughtful". Some scholars assert that science fiction had its beginnings in ancient times , when the line between myth and fact was blurred. Written in the 2nd century CE by the satirist Lucian , A True Story contains many themes and tropes characteristic of modern science fiction, including travel to other worlds, extraterrestrial lifeforms , interplanetary warfare, and artificial life . Some consider it

12091-482: The utility or meaning of body language , social reciprocity, or social expectations, including the habitus , social cues , and some aspects of sarcasm, which to some degree may also be due to comorbid alexithymia . But recent research has increasingly questioned these findings, as the " double empathy problem " theory (2012) argues that there is a lack of mutual understanding and empathy between both non-autistic persons and autistic individuals. As communication

12204-513: The world." The Tommy Westphall universe hypothesis makes the claim that not only does St. Elsewhere take place within Tommy's mind, but so do numerous other television series which are directly and indirectly connected to St. Elsewhere through fictional crossovers and spin-offs, resulting in a large fictional universe taking place entirely within Tommy's mind. This hypothesis was originally put forward by comic book and TV writer Dwayne McDuffie in

12317-404: Was influential on later filmmakers , bringing a different kind of creativity and fantasy . Méliès's innovative editing and special effects techniques were widely imitated and became important elements of the cinematic medium . 1927's Metropolis , directed by Fritz Lang , is the first feature-length science fiction film. Though not well received in its time, it is now considered

12430-480: Was known for its embrace of a high degree of experimentation, both in form and in content, and a highbrow and self-consciously " literary " or " artistic " sensibility . In 1961, Solaris by Stanisław Lem was published in Poland . The novel dealt with the theme of human limitations as its characters attempted to study a seemingly intelligent ocean on a newly discovered planet . Lem's work anticipated

12543-574: Was published and ICD-9 was current), including more rigorous biological assessment—in place of historical experience—and a simplification of the classification system. As of 2023, empirical and theoretical research is leading to a growing consensus among researchers that the established ASD criteria are ineffective descriptors of autism as a whole, and that alternative research approaches must be encouraged, such as going back to autism prototypes, exploring new causal models of autism, or developing transdiagnostic endophenotypes . Proposed alternatives to

12656-462: Was released in June 2018 and came into full effect as of January 2022. It describes ASD as follows: Autism spectrum disorder is characterised by persistent deficits in the ability to initiate and to sustain reciprocal social interaction and social communication, and by a range of restricted, repetitive, and inflexible patterns of behaviour, interests or activities that are clearly atypical or excessive for

12769-408: Was the first of his three- decade -long planetary romance series of Barsoom novels , which were set on Mars and featured John Carter as the hero . These novels were predecessors to YA novels , and drew inspiration from European science fiction and American Western novels . In 1924, We by Russian writer Yevgeny Zamyatin , one of the first dystopian novels, was published. It describes

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