4-555: 1LB4 , 1LB5 , 1LB6 , 2ECI , 2JMD , 3HCS , 3HCT , 3HCU , 4Z8M 7189 22034 ENSG00000175104 ENSMUSG00000027164 Q9Y4K3 P70196 NM_145803 NM_004620 NM_009424 NM_001303273 NP_004611 NP_665802 NP_001290202 NP_033450 TRAF6 is a TRAF human protein. The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins are associated with, and mediate signal transduction from members of
8-455: A family of proteins primarily involved in the regulation of inflammation , antiviral responses and apoptosis . Currently, seven TRAF proteins have been characterized in mammals : TRAF1 , TRAF2 , TRAF3 , TRAF4 , TRAF5 , TRAF6 and TRAF7 . Except for TRAF7, these proteins share a relatively conserved secondary structure , including a namesake C-terminal TRAF domain that mediates interactions with other signaling components such as
12-672: A link between distinct signaling pathways. This protein functions as a signal transducer in the NF-kappaB pathway that activates IkappaB kinase (IKK) in response to proinflammatory cytokines. The interaction of this protein with UBE2N/UBC13, and UBE2V1/UEV1A, which are ubiquitin conjugating enzymes catalyzing the formation of polyubiquitin chains, has been found to be required for IKK activation by this protein. Two alternatively spliced transcript variants encoding identical proteins have been reported. TRAF6 has been shown to interact with: TRAF TNF receptor associated factors ( TRAFs ) are
16-457: The TNF receptor superfamily. This protein mediates the signaling not only from the members of the TNF receptor superfamily, but also from the members of the Toll/IL-1 family. Signals from receptors such as CD40, TNFSF11/TRANCE/RANKL and IL-1 have been shown to be mediated by this protein. This protein also interacts with various protein kinases including IRAK1/IRAK , SRC and PKCzeta, which provides
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