113-659: Stockley Park is a business estate and public country park located between Hayes, Yiewsley, and West Drayton in the London Borough of Hillingdon. In August 2020, it was listed in the Register of Historic Parks and Gardens of Special Historic Interest in England as Grade II. Stockley Park is home to over twenty companies and corporations including Gilead Sciences , Canon Inc. , Sharp Corporation , Mitsubishi , Samsonite , Marks and Spencer and IMG Studios . In 2019, IMG Studios became
226-423: A chapel of ease ). St Matthew's Church was designed by Sir George Gilbert Scott and was consecrated on 6 July 1859. Yiewsley became a separate ecclesiastical parish in 1874. With the population of Yiewsley continuing to grow in the latter years of the 19th century, more room was required in the church. Architect Sir Charles Nicholson was consulted to design the enlargement to the church and its foundation stone
339-545: A willow tree species from that part of that world, and was therefore inspired to name his company Gilead. After founding Oligogen, he contacted the nonprofit about the naming issue and secured the right to use the Gilead Sciences name in exchange for a $ 1,000 donation. By 1988, the company had moved its headquarters to Foster City's Vintage Park neighborhood, where it has been based ever since. The company began to develop small molecule antiviral therapeutics in 1991, when
452-490: A branch of St Matthew's Church Infant School had also been established at Starveall. On 2 February 1890 Broad Harris and Co. entertained their tenants and employees at the inaugural opening of the Starvehall Mission Hall. The mission hall would become known as St. Mary's Church. However, by 1911 Starveall's descriptive name must have been of concern to its inhabitants as on 1 January 1912 the now Broad and Co. issued
565-438: A circular stating the following: The Directors of Broad and Co., Ltd beg to inform you that in response to the general desire of their tenantry, and others concerned at Starvhall, West Drayton, to have a 'more suitable designation of the place and works than that of "Starvhall" and "Starvhall Brickfields," they have decided, as from this date, to rename the place "Stockley" and the works to be known as "Stockley Works." Starveall
678-426: A column of fluid (90% paraffin to 10% of B.B. Mobiloil or P.924 (anti-freezing) oil) instead of a system of mechanical linkages which had been used in aircraft up until then. Once initial operational issues were overcome the C.C. Gear was not only more reliable than a mechanical linkage system, but also allowed a higher rate of fire and was readily adaptable to any type of engine and airframe. The first working C.C. gear
791-614: A committee of the House of Commons discussing the proposed Langley and Slough Branch of the Grand Junction canal that he had purchased his West Drayton brickfields (south of his existing Hillingdon Parish brickfields at Starveall) in March 1874 and had been making 15-20 million bricks per year. By the 1890s it is estimated 100 million bricks per year were being produced in West Middlesex supplying
904-437: A considerable height six or seven of the vans and store trucks of the goods train, scattering some of the wreckage, blocks of Bath stone and logs of timber and other goods over the railway, completely blocking both up and down line. The 2.15pm locomotive No. 583 from Paddington then ran into the debris throwing it off the line and derailing several of the carriages, which however were not overturned. The engine driver and fireman of
1017-634: A form of gene therapy . According to Riordan, he had always wanted to use the name Gilead Sciences all along. Still, he used Oligogen as a temporary name because he needed to deal with a trademark clearance issue with a California nonprofit organization that was already using the word Gilead in its name. He had first heard of the Balm of Gilead when he read Lanford Wilson 's play Balm in Gilead while in medical school, then learned that naturally occurring acetylsalicylic acid ( aspirin ) had been found in modern times in
1130-524: A licensing agreement with Parion for an epithelial sodium channel inhibitor for the treatment of pulmonary diseases, including cystic fibrosis, chronic obstructive pulmonary disease and bronchiectasis . In 2009, the company acquired CV Therapeutics, Inc. for $ 1.4 billion, bringing Ranexa and Lexiscan into Gilead. Ranexa is a cardiovascular drug used to treat chest pain related to coronary artery disease, with both of these products and pipeline building out Gilead's cardiovascular franchise. Later that year,
1243-508: A massive multi-year expansion of its 17-building headquarters campus in Foster City. By replacing eight one or two-story buildings with seven new structures ranging as tall as 10 stories, Gilead nearly doubled its headquarters real estate footprint from about 620,000 square feet to about 1.2 million square feet. On July 16, 2012, the FDA approved Gilead's Truvada for prevention of HIV infection (it
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#17328844018001356-618: A network of footpaths and bridleways for public use. Within the park is the Stockley Park Golf Club which features an 18-hole championship golf course , along with a bar and restaurant for visitors and also the Goulds Green Riding School which provides horse riding lessons. The park is served by three London bus routes: The Great Western Main Line runs to the south of Stockley Park. Hayes & Harlington railway station
1469-664: A pharmaceutical company. The San Francisco Chronicle noted that by 2003, the Gilead corporate campus in Foster City had expanded to "seven low-slung sand-colored buildings around a tiny lake on which ducks happily paddle." Like many startups, Gilead originally leased its space, but in 2004, the company paid $ 123 million to buy all its headquarters buildings from its landlords. However, even as Gilead developed its ability to distribute and sell its own drugs, it remained distinct from most pharmaceutical companies in terms of its strong reliance on subcontracting most of its manufacturing to contract manufacturing organizations . In 2004, during
1582-464: A pill's price was as low as $ 4.29. Gilead later combined Sovaldi with other antivirals in single-pill combinations. First, Sovaldi was combined with ledipasvir and marketed as Harvoni . This treatment for hepatitis C cures the patient in 94% to 99% of cases (HCV genotype 1). By 2017, Gilead was reporting drastic drops in Sovaldi revenue from year to year, not only because of pricing pressure but because
1695-576: A price of US$ 133.3 million . Raylo Chemical, based in Edmonton, Alberta , was a wholly-owned subsidiary of Degussa AG , a German company. Raylo Chemical was a custom manufacturer of active pharmaceutical ingredients and advanced intermediates for the pharmaceutical and biopharmaceutical industries. Later in the same year, Gilead acquired Myogen, Inc. for $ 2.5 billion (then its largest acquisition). With two drugs in development (ambrisentan and darusentan), and one marketed product (Flolan) for pulmonary diseases,
1808-578: A prolonged stalemate which may have lasted up to six months, an agreement was reached for the Danes to leave peacefully. Hostages were taken as collateral and vows made by the Danes that they would leave the Anglo-Saxon lands and go directly to the lands under Danish control which they duly did, without any of their plundered spoils. Yiewsley (or Wifeleslēah ) and the land of the Middle Saxons had been part of
1921-474: Is a common and possibly humorous description in central southern England for land of poor fertility - (Starve all). By the middle of the 19th century a significant brickfield has been established to the west of Starveall farm. An arm known as Starveall dock (and also as Pocock's or Broad's dock) was cut from the Grand Junction Canal to service the brickfield. In 1872 it was extended south of the farm into
2034-521: Is a large suburban village in the London Borough of Hillingdon , England, 2 miles (3 km) south of Uxbridge , the borough's commercial and administrative centre. Yiewsley was a chapelry in the ancient parish of Hillingdon, Middlesex . The population of the ward was 12,979 at the 2011 Census . Yiewsley is not recorded in the Domesday Book of 1086. The place-name is believed to be derived from
2147-521: Is a major source of employment in the area. Primary schools in Yiewsley: Secondary school: Special and Alternative schools: Until the mid-19th century, Yiewsley was a district of the parish of St John the Baptist church, Hillingdon. After the opening of the brick-fields, Yiewsley's population started to grow, and work began to provide for the building of a Mission Church (also referred to as
2260-603: Is an American biopharmaceutical company headquartered in Foster City, California , that focuses on researching and developing antiviral drugs used in the treatment of HIV/AIDS , hepatitis B , hepatitis C , influenza , and COVID-19 , including ledipasvir/sofosbuvir and sofosbuvir . Gilead is a member of the Nasdaq-100 and the S&;P 100 . Gilead was founded in 1987 under the name Oligogen by Michael L. Riordan. The original name
2373-507: Is considered to have played a significant role in achieving final air superiority over the Luftstreitkrafte . On 25 March 1919 Queen Mary and Queen Marie of Romania visited the Sonic laboratory. Constantinescu was warmly congratulated by the two queens for his work. In the 1920s Trout road developed as a centre for companies involved in oils and chemical production. In 1921 K.B Mavlankar
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#17328844018002486-564: Is entirely out of order: they ought first to have applied to this Council." However, there was general agreement with the name change. Vice-chairman of the council Mr T. Hancock stated "he saw no reason why the name should not be altered. Starveall was not a correct name, for nobody had been starved there." Starveall was subsequently expunged, with Starveall Road, Starveall Farm, Starveall Infant School, Starveall Church Mission Hall, Starveall Football Club and Starveall Brickworks all being renamed Stockley. The only reference to Starveall today lies on
2599-571: Is located 1.2 miles (1.9 km) to the southeast. The Elizabeth Line operates a stopping service between Reading and Shenfield or Abbey Wood as well as to Heathrow Terminal 4 . West Drayton railway station is located 1.1 miles (1.7 km) southwest of Stockley Park. It has the same services as Hayes and Harlington station with the exception of the service to Heathrow Terminal 5. Heathrow Airport lies 3.5 miles (5.6 km) south of Stockley Park. The land which became Stockley Park lay in two ancient Middlesex parishes, Hillingdon Parish in
2712-430: Is outside the U.S. and is unavailable for acquisitions unless Gilead pays U.S. tax on it, though it could borrow against it. Gilead would benefit from proposals to let companies repatriate offshore capital with minimal further taxation. Gilead's Entospletinib has shown a 90% complete response rate for MLL type acute myeloid leukaemia (AML). Several mass tort lawsuits have been filed against Gilead alleging that
2825-479: The Fortune 500 . Charitable donations to HIV/AIDS and liver disease organizations totaled over 440 million in 2015. In August 2017, the company announced it would acquire Kite Pharma for $ 11.9 billion, equating to $ 180 cash per share, a 29% premium over the closing price of the shares. The deal was Gilead's entry into the cell therapy market and added a chimeric antigen receptor T cell ( CAR-T ) therapy candidate to
2938-787: The Anglo-Saxon Wifeleslēah : "Wifel's woodland clearing". The earliest written record of Yiewsley is from 1235 where it is shown as Wiuesleg in Assize Rolls . The western side of Yiewsley lies within the Colne Valley Regional Park . Here the River Colne forms the county boundary between the London Borough of Hillingdon and Buckinghamshire . The confluence of the Frays River and River Pinn also occurs in this area and there are several man-made lakes. After climbing over
3051-497: The Avian flu pandemic scare, Gilead Sciences' revenue from Tamiflu almost quadrupled to $ 44.6m as more than 60 national governments stockpiled the antiviral drug, though the firm had made a loss in 2003 before concern about the flu started. As stocks soared, US Defense Secretary and Pentagon chief Donald Rumsfeld sold shares of the company, receiving more than $ 5 million in capital gains, while still maintaining up to $ 25m-worth of shares by
3164-591: The Beeching report was the closure of over 2000 railway stations across Great Britain. From 1968 until 1980 a policy was adopted by the British Railways Board to shorten the remaining stations' names where possible. This policy resulted in Yiewsley being removed from the station name after 79 years on the 6 May 1974. Yiewsley today is a growing community with both residential housing and commercial businesses. With
3277-851: The Chiltern Hills by the use of 52 locks from the Marsworth Junction, the Grand Union Canal turns east in Yiewsley to route towards London . Half a mile north of this turn, the five miles long Slough Arm of the canal leaves the Grand Union main line at the Cowley Peachey Junction , crossing over the Frays River and River Colne in aqueducts on its westward route towards the Slough basin. On
3390-676: The Johns Hopkins School of Medicine , and the Harvard Business School . The idea for Gilead began as a research project at Menlo Ventures , where Michael was an associate. Three scientific advisers worked with Riordan to create the company: Peter Dervan of Caltech , Doug Melton of Harvard , and Harold M. Weintraub of the Fred Hutchinson Cancer Research Center , along with H. Dubose Montgomery, one of Menlo Ventures founders. Riordan served as CEO from
3503-597: The Kingdom of Essex but came under Mercian control in the reign of King Æthelbald (716-757AD). By the time of the siege of Thorney Island in 893, eastern Mercia had conquered by the Danes and with his power diminished Æthelred had been forced to cede overlordship to King Alfred the Great of Wessex. When Æthelred died in 911, Middlesex was annexed by Wessex under Alfred's son, now King Edward (899-924AD). Edward would go on to take control of all of Mercia, both Angle and Danish, advancing
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3616-454: The 1920s. However the resources of brick-earth began to become depleted. By 1930 the Stockley brickworks were producing only two million bricks a year. In 1935 the brickworks was closed down. In 1949-50 the Stockley housing estate was constructed to the west of the hamlet by the Yiewsley and West Drayton Urban District Council . However without its brickmaking raison d'être , the hamlet itself
3729-591: The 1930s a number of smaller companies engaged in manufacturing chemicals, plastics, and engineering components were established on and around Trout Road, this would develop to being more than forty companies in the area. Two firms began production of motor vehicles in Yiewsley after the Second World War. Road Machines of Horton Parade employed 250 people manufacturing a range of contractors' plant including weight batching equipment, dumpers and Mono-Rail transporters. An adaption of their modular-track monorail system
3842-663: The 1970s. The construction of the Great Western Railway (GWR) began in 1835 and the line between Paddington and Maidenhead was opened on 4 June 1838 with West Drayton being its first station. The locomotive Vulcan had become the first to run on the Great Western Railway on 28 December 1837 when it completed a successful mile and a half test run down the line from Yiewsley to Iver. Having been constructed in Newton-le-Willows by Charles Tayleur & Co. ,
3955-416: The 19th century, it would appear businesses believed it was commercially advantageous to adopt West Drayton as their address. By the 1960s the demand for rail travel was falling. The branch line to Uxbridge Vine St was particularly affected by competition from the town's London Underground lines. Passenger services to Uxbridge were stopped in 1962, however a short section of line (approximately 745 yards) to
4068-521: The 2010s. However, it came under heavy scrutiny over its business practices, including extremely high pricing of drugs such as Sovaldi and Truvada in the United States relative to production cost and cost in the developing world. In June 1987, Gilead Sciences was originally founded under the name Oligogen by Michael L. Riordan, a medical doctor. Riordan graduated from Washington University in St. Louis ,
4181-446: The 2011 acquisition of Pharmasset. In 2013, the FDA approved this drug, under the trade name Sovaldi, as a treatment for the hepatitis C virus . Forbes magazine ranked Gilead its number 4 drug company, citing a market capitalization of US$ 113 billion and stock appreciation of 100%, and describing their 2011 purchase of Pharmasset for $ 11 billion as "one of the best pharma acquisitions ever". Deutsche Bank estimated Sovaldi sales in
4294-747: The Alliance Engine Works. In 1880 Edward Stewart & Co operated the West Drayton cement works and in 1890 the Electrical Engineering Corporation was making electrical equipment and Dynamos. An Indian rubber mill had been established by 1894 on Trout Road, in 1900 it was owned J.E Hopkinson & Co. In 1898 the Padcroft Saw Mills were being operated by John A. Holland. By 1900 the Rotary Photographic Company
4407-683: The Autumn of 1795 with measures undertaken there to allow traffic to pass through. In the next year 1796, Yiewsley's first dock, Colham wharf was opened next to Colham Bridge. In 1801 the Paddington Arm of the canal opened from Bulls Bridge near Hayes and would be of national importance as a trade route into and from the Capital. The building of the canal enabled the bulk transportation of what became known as Cowley (or London) stock bricks , made from Yiewsley's rich deposits of brick-earth. The first record of
4520-706: The Lithographic Printing Works. Also in 1916 the Onslow Cotton Mill was established on Trout Road. In late 1917 The West Drayton Glass Works was founded on Horton Road. In 1918 Frederick Bird & Co of the West Drayton Engineering Works also on Horton Road had been manufacturing engineering products to the Army and Navy as part of the war effort. Government contracts were also given to Squire & Son to produce glycerine and Messrs Sabey for
4633-522: The Middlesex Oil and Chemical Works on Trout Road continued in use for freight services until 8 January 1979. The Staines line was closed to passengers in 1965 as a consequence of 1963 report ‘The Reshaping of British Railways’ by Dr Richard Beeching, Chairman of the British Railways Board (BRB). The line continues to be used for freight services as far as Colnbrook. Another consequence of
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4746-530: The Parish of West Drayton , reaching a distance of 1120 yards from the mainline of the canal. In 1879 the leaseholder of Starveall, Samuel Pocock, stated he made 15-20 million bricks per year there. In 1884 Pocock conveyed his interests to Clement Burgess Broad and George Harris, of South Wharf, Paddington. The hamlet of Starveall continued to grow. By 1885 a church mission room with services held in affiliation with St. Matthew's Church, Yiewsley had been built. By 1888
4859-457: The Parish of West Drayton. West Drayton remained a largely rural village until into the 20th Century and then developed into a mostly residential area. A possible answer to this is that railway station had been called West Drayton station since its opening in 1838 and only changed to West Drayton and Yiewsley in 1895. With the Railways becoming the principal form of transportation in the latter half of
4972-568: The River Colne and Frays River powering eight corn mills in the Parish. The nearest mills to Yiewsley were Colham Mill (called Lower Colham Mill from around 1746) in the south of the Parish and Yiewsley Mill which was situated on the northern side of Yiewsley Moor on the north side today's Little Britain Lake. The oldest buildings in Yiewsley today date from the late 16th century or early 17th century and are situated at either end of Yiewsley High Street. At
5085-519: The Thames deposited layers of fluvial terrace gravels , silts , sands and loams on the Middle Thames area with silts forming brickearth . Within the brickearth and gravels deposited by the Thames significant quantities of early human tools were found when commercial excavations began in Yiewsley on an industrial scale in the 19th century. The first person to start collecting artifacts from Yiewsley
5198-627: The West Saxon army in pursuit. Having reached the River Colne the Danes mounted a defence on what was known as Thorney Island, believed to be land between the Colne and an offshoot channel of the river between Thorney and Iver , approximately half a mile west from Yiewsley High Street today. Edward began a siege of the island and was joined by Æthelred of Mercia with soldiers from the Mercian garrison in London. After
5311-550: The acquisition of Myogen has solidified Gilead's position in this therapeutic arena. Under an agreement with GlaxoSmithKline , Myogen marketed Flolan ( epoprostenol sodium ) in the United States for the treatment of primary pulmonary hypertension . Additionally, Myogen was developing (in Phase 3 studies) darusentan, also an endothelin receptor antagonist, for the potential treatment of resistant hypertension . Gilead expanded its move into respiratory therapeutics in 2007 by entering into
5424-420: The afternoon of 6 February 1874 a double collision occurred in thick fog on the mainline by Horton Bridge. The 10.25am Exeter Express drawn by the locomotive Prometheus traveling at around 60mph towards Paddington collided with the rear of a stationary Bristol goods train ladened with timber and blocks of Bath stone which was in the process of being moved into sidings. The trains were rammed together piling up to
5537-480: The bronze BAFTA awards. West Drayton railway station is located at the southern end of Yiewsley High Street and is on the Great Western Main Line . The Elizabeth line operates a stopping service between Abbey Wood and Reading and Great Western Railway (GWR) operates a stopping service between London Paddington and Didcot Parkway . Yiewsley is served by the nearby M4 and M25 motorways which lie
5650-608: The building to develop the engineering inventions of George (Gogu) Constantinescu . Constantinescu had begun the development the Constantinesco-Colley Fire Control Timing Gear (C.C. Gear) for synchronizing machine gun fire through aircraft propellers at his laboratory at the Haddon Engineering Works in Alperton . His system worked by using wave pulses which were generated and transmitted from
5763-720: The business announced it would acquire German biotech, MYR GmbH, for €1.15 billion plus up to a further €300 million. MYR focuses on the treatment of chronic hepatitis delta virus . On August 11, 2021, U.S. Senator Rand Paul disclosed that his wife Kelley Paul had purchased a stake in Gilead Sciences on February 26, 2020. In November 2021, the company was added to the Dow Jones Sustainability World Index . In January 2022, Gilead pulled its cancer drug Zydelig (idelalisib) from its accelerated approval in relapsed follicular B-cell non-Hodgkin lymphoma (FL) and relapsed small lymphocytic leukemia (SLL). In September,
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#17328844018005876-582: The canal network managed by the Canal & River Trust . The Grand Union Canal Bridge 195 is still known as Starveall Bridge. In January 1918 three hundred Royal Naval Air Service (RNAS) personnel were stationed at Stockley. A depot was established as the main base for the RNAS Air Construction Corps (ACC). The depot had a Repair Shop, two Stores, Packing and Receiving Rooms, Officers' Mess and Quarters, Executive Office, Sergeants' Mess and Quarters for
5989-555: The company acquired Calistoga Pharmaceuticals for US$ 375 million ($ 225 million plus milestone payments). The acquisition boosted Gilead's oncology and inflammation areas. Later that year, Gilead made its most important acquisition – and by then most expensive – with the US$ 10.4 billion purchase of Pharmasset , Inc. This transaction helped cement Gilead as the leader in treatment of the hepatitis C virus by giving it control of sofosbuvir (see below). In October 2011, Gilead broke ground on
6102-450: The company announced it would acquire Forty Seven Inc. for $ 95.50 a share ($ 4.9 billion in total). On April 7, 2020, Gilead completed acquisition of Forty Seven, Inc. for "$ 95.50 per share, net to the seller in cash, without interest, or approximately $ 4.9 billion in the aggregate." In June 2020, Bloomberg reported that AstraZeneca Plc had made a preliminary approach to Gilead for a potential merger, worth almost $ 240 billion. In
6215-518: The company completed its acquisition of MiroBio for $ 405 million. In February 2023, the business, through Kite Pharma completed its acquisition of Tmunity Therapeutics In May, the business announced it would acquire XinThera and its small molecule inhibitors. In February 2024, the company acquired CymaBay Therapeutics , and in September, paid Genesis Therapeutics $ 35 million for AI-based drug discovery work. The drug sofosbuvir had been part of
6328-568: The company deliberately delayed development of antiretroviral drugs based on tenofovir alafenamide fumarate (TAF) in order to maximize profits from previous-generation medications containing tenofovir disoproxil fumarate (TDF) . Plaintiffs allege that Gilead suspended TAF in 2004 despite clear evidence indicating that TAF-based medications were safer than TDF, a compound whose long-term use was associated with adverse side effects such as nephrotoxicity and bone density loss. Yiewsley Yiewsley ( / ˈ j uː z l i / YOOZ -lee )
6441-459: The company in-licensed a group of nucleotide compounds including tenofovir . Riordan later recalled that Gilead's first decade as a startup was an extremely stressful experience for him, as a young venture capitalist serving for the first time as the founder, chairman, and chief executive officer of his own biotech company. The new company had no products and very little income, and narrowly escaped going out of business on several occasions: "It
6554-456: The company made a trio of acquisitions: In 2016, the company acquired Nimbus Apollo, Inc. for $ 400 million, giving Gilead control of the compound NDI-010976 (an ACC inhibitor) and other preclinical ACC inhibitors for the treatment of non-alcoholic steatohepatitis and for the potential treatment of hepatocellular carcinoma . Also in 2016, the company was named the most generous company on the 2016 Fortune list of The Most Generous Companies of
6667-472: The company was named one of the Fastest Growing Companies by Fortune . In 2010, the company acquired CGI Pharmaceuticals for $ 120 million, expanding Gilead's research expertise into kinase biology and chemistry. Later that year, the company acquired Arresto Biosciences, Inc. for $ 225 million, obtaining developmental-stage research for treating fibrotic diseases and cancer. In February 2011,
6780-515: The company's founding until 1996. Menlo Ventures subsequently made the first investment in Gilead of $ 2 million. Riordan also recruited scientific advisers, including Harold Varmus , a Nobel laureate who later became Director of the National Institutes of Health , and Jack Szostak , recipient of the Nobel Prize for Physiology or Medicine in 2009. The company's primary therapeutic focus
6893-465: The company's portfolio. By 2022 this acquisition had led to two marketed products for lymphoma: Yescarta and Tecartus . In November, the company announced it will acquire Cell Design Labs for up to $ 567 million, after it indirectly acquired a stake of 12.2% via the Kite Pharma deal. On May 9, 2019, the U.S. Department of Health and Human Services announced that Gilead Sciences will donate Truvada,
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#17328844018007006-448: The demand for building materials of Victorian London . With this high production rate the deposits of brick-earth began to become depleted around the turn of the century. Brick-earth was still being extracted from Hide Field to the east of Yiewsley in 1913 but by 1930 the Stockley brickworks were producing only 2 million bricks a year. The brickworks were closed in 1935, but the underlying gravels and sands continued to be extracted until
7119-456: The east lies Stockley Park and to the south, across the Great Western Railway is West Drayton . Over tens of thousands of years the course of the River Thames moved south, first flowing to the north of Yiewsley, then over the Yiewsley area until reaching its present course today where it lies 4.8 miles (7.7 km) to the southwest of Yiewsley at its closest point. Over thousands of years
7232-413: The eastern side of Yiewsley lies Stockley Country Park. Within its 274 acres of parkland lies a comprehensive network of footpaths. To the west of Yiewsley, beyond the River Colne lie the Buckinghamshire villages of Iver , Richings Park and Thorney. To the north, over the River Pinn is Cowley Peachey . To the northeast of Yiewsley is Hillingdon and the villages of Colham Green and Goulds Green. To
7345-399: The end of the year. Sales of Tamiflu almost quadrupled again in 2005, to $ 161.6m, during which time the share price tripled. A 2005 report showed that, in all, Rumsfeld owned shares worth up to $ 95.9m, from which he got an income of up to $ 13m. In 2006, the company acquired Corus Pharma, Inc. for $ 365 million. The acquisition of Corus signaled Gilead's entry into the respiratory arena. Corus
7458-439: The establishment of the Elizabeth line and as a consequence of the London Plan and Hillingdon Local Plan there has been significant construction of residential apartments on former industrial and manufacturing sites. Yiewsley has an active High Street with national retail outlets Tesco, Iceland, B&M Stores, Home Bargains, Aldi and Savers situated on it. Together with local businesses in Yiewsley and Uxbridge, Heathrow airport
7571-410: The first time, and indicating occupation during the Neanderthal period some 70,000 years ago – a period of man's development otherwise poorly represented in the archaeology of Britain” In 1913–1914, there was the discovery of a Bronze Age urnfield cemetery with the excavation of 14 Deverel-Rimbury cinerary urns. These and other Bronze Age items have been cataloged at the British Museum . In
7684-411: The following with regard to the archaeological significance of the Yiewsley sites: “..the Yiewsley pits have yielded one of the largest series of Lower Palaeolithic stone hand tools in Europe and the area remains one of the richest Palaeolithic sites in Britain.” “A feature unique to Yiewsley is the presence in a higher level of stone tools of a Middle palaeolithic ( Mousterian ) date, isolated for
7797-411: The former hamlet of Stockley. "Stockley" is believed to be a portmanteau word derived from Cowley stock , the generic name given to the locally produced brick in West Middlesex. The hamlet of Stockley came into being with the renaming of the hamlet of Starveall (or Starvhall/Starvehall) in 1912. Starveall was located in the ancient parish of Hillingdon, lying south of the Grand Junction Canal. The name
7910-410: The late 14th century, wheat was the predominant crop grown, but also rye and oats were farmed. Surplus grain was sold in London or Uxbridge . By the 12th Century Uxbridge had become the market town for the Parish of Hillingdon and it is thought by the 14th Century the town's population had exceeded that of the rest of the Parish, and this remained the case until the 1821 census . By 1600 Uxbridge
8023-499: The location of the video assistant referee (VAR) hub for English domestic football . The hub is operated by the Professional Game Match Officials Limited (PGMOL) and is responsible for officiating decisions during matches. As a result, "Stockley Park" is sometimes used as a metonym for the VAR officials or the decisions made during football matches. The Stockley Park Quayside area has the following amenities: Stockley Country Park spans 274 acres (111 ha) of parkland and offers
8136-544: The locomotive were saved by jumping clear before the impact. The guard of the Exeter Express was a fatality in the accident, but there were no serious injuries inflicted on any of the passengers. West Drayton station was relocated east to its present position on Station Approach from Tavistock Road on the 9 April 1884, four months before a second branch line, operated by the Staines and West Drayton Railway (S&WDR)
8249-422: The locomotive, together with another engine called Premier had been taken by barge from the London docks and unloaded between Horton Bridge and West Drayton Station. On 9 April 1839 the world's first commercial telegraph was inaugurated between Paddington and West Drayton Station by William Fothergill Cooke and Charles Wheatstone . A GWR branch line to Uxbridge Vine Street was opened on 8 September 1856. On
8362-520: The men. With the formation of the RAF on 1 April 1918 the depot became RAF West Drayton . Approximately 70 men of Stockley served in the armed forces in the First World War with 11 giving their lives in the conflict. A war memorial tablet bearing their names was erected outside the mission hall which was unveiled in a ceremony on 6 January 1921. Stockley continued to be a centre of brick production through
8475-714: The names of the 73 men of the parish who fell in the Second World War. A ceremony with the laying of wreaths is held at the War Memorial on Remembrance Sunday each year. Yiewsley's main commercial area is on and adjacent to Horton Road. There are over 70 businesses located here including the Speedfit manufacturer John Guest ( RWC Ltd ) and the data centre company Virtus, who have the UK's largest data centre campus at Prologis Park West London. New Pro Foundries in Horton Close have produced
8588-787: The northern end of the High Street is Yiewsley Grange ( Also known as Brookside ) which overlooks the River Pinn and is Hillingdon Manor School today. Next to Yiewsley Grange is the Six-bay Barn at Philpot's Yard (Formally Philpot's Farm). At the southern end of the High Street is the De Burgh Arms Public house, named in honour of the De Burgh family who became the Lords of Colham Manor from 1787. Yiewsley's agrarian way of life started to change with
8701-425: The number of suitable patients decreased. Later single-pill combinations were Epclusa (with velpatasvir ) and Vosevi (with velpatasvir and voxilaprevir ). For the fiscal year 2017, Gilead Sciences reported earnings of US$ 4.628 billion and annual revenue of US$ 26.107 billion, a decline of 14.1% over the previous fiscal cycle. Gilead Sciences's shares traded at over $ 70 per share, and its market capitalization
8814-418: The only drug approved to prevent infection with H.I.V., for free to 200,000 patients annually for 11 years. On December 3, 2019, HHS explained how the government would distribute the donated drugs. HHS Secretary Alex Azar explained that the U.S. government will pay Gilead $ 200 per bottle for 30 pills for costs associated with getting the drug from factories into the eventual hands of patients. In March 2020,
8927-581: The opening of the Grand Junction Canal . Construction began with cuttings on Uxbridge Moor on 1 May 1793 and in early May at Brentford and Braunston . From the Thames at Brentford to Hanwell , the canal was engineered from the River Brent . At Hanwell the canal parted from the Brent and was routed west, following the natural 100 foot contour to avoid the building of expensive and time consuming locks . It
9040-691: The outgoing transportation of bricks and the importing of coal from the Midlands to fire Yiewsley's clamp kilns . The finished bricks were then transported mainly along the Grand Junction Canal to South Wharf in the Paddington Basin and to wharves along the Regent's Canal , but also to other locations along the canal and River Thames. Although figures for Yiewsley's brick production in the nineteenth century are not available, in July 1879 brickmaker Samuel Pocock stated at
9153-449: The people of Yiewsley in time to come might bring their children to it and point out to them the names of father, grandfather or some other relative and tell them of the great things that were done by their predecessors so that it might be an inspiration and hope for the future. On Sunday 4 October 2009 the war memorial was rededicated by Peter Broadbent , the Bishop of Willesden , to include
9266-560: The pits that were produced were used to deposit waste by barge from London. With the development of the Park in 1984-1985 approximately five million tonnes of waste was moved in the creation of the business park, the largest civil engineering contract involving landfill transfer in Europe. The estate was developed by Stanhope and designed by Arup Group from 1984. A Phase II development was added between 1990 and 1998. Stockley Park takes its name from
9379-655: The progression of England being united into a single kingdom. For the majority of its existence Yiewsley was a hamlet in the Parish of St John the Baptist Church, Hillingdon , with a tenurial relationship with Colham Manor. Before the Norman Conquest, Colham Manor had belonged to Wigot of Wallingford. By the time of Domesday Book in 1086 it was the property of one of William the Conqueror's principle advisors, Roger de Montgomery . In Colham Manor's fertile arable fields in
9492-458: The sale of significant numbers of bricks in Yiewsley is shown in the Public Ledger and Daily Advertiser of the 24 March 1809, advertising an auction of upwards of one million bricks owned by W.M Pope situated at a site adjoining the canal. In 1820 a branch of the canal known as Otter Dock was opened. It would become the longest of nine arms and docks that were constructed in Yiewsley to service
9605-405: The same month, the company announced it would acquire a 49.9% stake in privately held Pionyr Immunotherapeutics Inc for $ 275 million. In September 2020, Gilead announced it had reached a deal to acquire Immunomedics for $ 21 billion ($ 88 per share), gaining control of the cancer treatment Trodelvy ( Sacituzumab govitecan -hziy) – a first-in-class Trop-2 antibody-drug conjugate. In December,
9718-557: The spring of 893, after overwintering at Appledore and then plundering through Kent and Sussex , a Viking raiding army turned to head for the Danish controlled lands in the east (later known as the Danelaw ). However they were intercepted by Alfred the Great's son Edward with his West Saxon Fyrd at Farnham in Surry. The Danes were routed, fleeing over the River Thames into Mercia with
9831-616: The supply of gravel. In 1919 The Anglo-Swiss Screw Company was established on Trout Road, the same year as the S.C. Johnson & Son wax company opened their factory on the site of Colham Wharf. In 1920 the Admiralty Engineering Laboratory was operational in the south of the Yiewsley Urban District, specializing in experimental work for the Royal Navy. During the war the Sonic laboratory had been established in
9944-469: The treatment of cytomegalovirus (CMV) retinitis in patients with AIDS . In January 1997, Donald Rumsfeld was appointed chairman, but left the board in January 2001 when he was appointed United States Secretary of Defense during George W. Bush 's first term as president. In March 1999, Gilead acquired NeXstar Pharmaceuticals of Boulder, Colorado . At the time, NeXstar's annual sales of $ 130 million
10057-469: The unveiling. In the address he stated that the population of Yiewsley at the time was something under 5,000, but more than 530 men of the parish had served in His Majesty's Army during the war – more than one in ten of the whole population of the place including women and children. Before closing his address with the names of the men inscribed on the memorial, he stated that it had been put there in order that
10170-601: The west and Harlington Parish in the east. In the Harlington Parish what became the eastern part of Stockley Park was within the estate of Dawley Manor and later the Dawley Wall farm. In Hillingdon Parish the land lay within Colham Manor. After the cutting of the Grand Junction Canal (renamed Grand Union Canal in 1929) land was leased for brick-earth and later gravel and sand extraction. When deposits were exhausted some of
10283-477: The year's final quarter would be $ 53 million, and Barron's noted the FDA approval and subsequent strong sales of the "potentially revolutionary" drug as a positive indicator for the stock. On July 11, 2014, the United States Senate Committee on Finance investigated Sovaldi's high price ($ 1,000 per pill; $ 84,000 for the full 12-week regimen). Senators questioned the extent to which the market
10396-401: Was emtricitabine that was near FDA approval, and it had two other antivirals in its pipeline. The company also announced its first full year of profitability. Later that year, Hepsera ( adefovir ) was approved for the treatment of chronic hepatitis B , and Emtriva ( emtricitabine ) for the treatment of HIV. During this era, Gilead completed its gradual evolution from a biotech startup into
10509-718: Was John Allen Brown (1833-1903) a Fellow of the Geological Society who collected between 1889 and 1901. The principle collector was Robert Galloway Rice (1852-1933), a Fellow of the Society of Antiquaries who recorded over 2600 items from the Yiewsley area between approximately 1905 and 1929. In 1937 his collection of Lower Palaeolithic and Middle Palaeolithic artifacts was donated to the Museum of London . In his 1978 Archaeological Report, Early Man in West Middlesex, The Yiewsley Palaeolithic sites , Palaeontologist Desmond Collins states
10622-538: Was a reference to oligonucleotides , small strands of DNA used to target genetic sequences. Gilead held its initial public offering in 1992, and successfully developed drugs like Tamiflu and Vistide that decade. In the 2000s, Gilead received approval for drugs including Viread and Hepsera , among others. It began evolving from a biotechnology company into a pharmaceutical company, acquiring several subsidiaries, though it still relied heavily on contracting to manufacture its drugs. The company continued its growth in
10735-597: Was already approved for treating HIV). The pill was a preventive measure ( PrEP ) for people at high risk of getting HIV through sexual activity. In 2013, the company acquired YM Biosciences , Inc. for $ 510 million. The acquisition brings drug candidate CYT387 , an orally-administered, once-daily, selective inhibitor of the Janus kinase (JAK) family, specifically JAK1 and JAK2, into Gilead's oncology pipeline. The JAK enzymes have been implicated in myeloproliferative diseases, inflammatory disorders, and certain cancers. In 2015,
10848-503: Was cut through Yiewsley, turning north to follow the route of the River Colne , crossing over the Fray's River in an aqueduct at Cowley Lock. On Monday 3 November 1794 the canal was opened between the River Thames and Uxbridge . However toll collectors weren't appointed at Uxbridge and Brentford until May 1795. It is likely the aqueduct over the Fray's River at Cowley Lock wasn't completed until
10961-521: Was developing aztreonam lysine for the treatment of patients with cystic fibrosis who are infected with Pseudomonas aeruginosa . In July 2006, the U.S. Food and Drug Administration (FDA) approved Atripla , a once a day single tablet regimen for HIV, combining Sustiva ( efavirenz ), a Bristol-Myers Squibb product, and Truvada ( emtricitabine and tenofovir disoproxil ), a Gilead product. Gilead purchased Raylo Chemicals, Inc. in November 2006, for
11074-533: Was established by 1864 in the south of the Parish. The Hillingdon Varnish works, situated to the west of Iron Bridge Road had been established by 1868. In June 1890 it was owned by Messrs Wilkinson, Heyward and Clark. In 1874 W. Gillespie & Co were manufacturing engines and boilers at the Foundry and Engineering Works and in 1875 Horizontal Condensing Engines were being made by Edwin Philip Bastin & Company at
11187-828: Was established opposite Lower Colham Mill and in 1903 the Power Plant Co was established producing Helical Gears and couplings. In the First World War they supplied steam turbines for the Royal Navy. In 1913 the Steam Fittings Company Limited in Horton Road was producing ‘Steam traps’ to be used in Navy vessels. The company changed its name to the Drayton Regulator and Instrument Company in 1926. Also by 1913 printing works had been established on Tavistock Road and Horton Bridge Road. In 1916 C.J. Culliford & Co operated
11300-559: Was in antiviral medicines, a field that piqued Riordan's interest after he contracted dengue fever . Riordan recruited Donald Rumsfeld to join the board of directors in 1988, followed by Benno C. Schmidt, Sr. , Gordon Moore , and George P. Shultz . Riordan tried to recruit Warren Buffett as an investor and board member but was unsuccessful. The company focused its early research on making small strands of DNA ( oligomers , or more particularly, oligonucleotides ) to target specific genetic code sequences – that is, antisense therapy ,
11413-483: Was laid on 24 September 1897. The Church was consecrated by the Bishop of London on 25 April 1898. Yiewsley War Memorial stands in the grounds of St Matthew's Church. It was unveiled on Saturday 28 May 1921 by Lady Delia Peel in honour of the 128 men of the parish who fell in the Great War. Her husband, Yiewsley's Member of Parliament Col. Hon. Sidney Peel , gave an address to the assembled people of Yiewsley before
11526-561: Was located within the Yiewsley Urban District and Broad & Co unilateral renaming of Starveall caused some disquiet at the Council meeting on Tuesday 9 January 1912. It was pointed out that Broad & Co. had thought that they could rename Starveall without sanction and afterwards had realised their mistake and had written to the council asking them to pass a resolution confirming their action. Council member Mr J.A. Holland stated "It
11639-461: Was opened on the 9 August 1884. In 1895 the station was renamed West Drayton and Yiewsley station . By the middle of the 19th Century brick production and flour milling were Yiewsley's main industries; However new industry was beginning to develop. The Victoria oil mills near Colham Wharf was established before 1855. In 1865 it was owned by Walter Graham & Co and was producing linseed cake. A chemical works owned by Alfred White and Sons in 1890
11752-546: Was operating "efficiently and rationally", and committee chairman Ron Wyden ( D - Oregon ) and ranking minority member Chuck Grassley ( R - Iowa ) wrote to CEO John C. Martin asking Gilead to justify the price for this drug. The committee hearings did not result in new law, but in 2014 and 2015, due to negotiated and mandated discounts, Sovaldi was sold well below the list price. For poorer countries, Gilead licensed multiple companies to produce generic versions of Sovaldi; in India,
11865-740: Was producing Essential Oils at the British Aromatic Chemical Works on Trout Road. From 1928 the Kenilworth Chemical Manufacturing Company and the English Metal Powder Company operated factories in Trout Road. Their factory was transferred after 1935 to the Middlesex Oil and Chemical Works Ltd, manufacturing oils, petroleum jellies, and resins. The Kenilworth Chemical and English Metal Powder companies then moved to an adjoining site in Trout Road. From
11978-607: Was razed with the Stockley Close Industrial estate today lying where the hamlet was situated. To the industrial estate's east and south lies a truncated 409-yard section of the former canal arm. Some of the buildings of Stockley Farm remain and to its west lies a small local park, Stockley Recreation Ground, which serves the Stockley housing estate. 51°30′36″N 0°26′38″W / 51.510°N 0.444°W / 51.510; -0.444 Gilead Sciences Gilead Sciences, Inc. ( / ˈ ɡ ɪ l i ə d / )
12091-619: Was successfully air-tested on a B.E.2c aircraft in August 1916 and was fitted to No.55 Squadron's DH.4's before their arrival in France on 6 March 1917. In the following days they were joined by Bristol Fighters of No 48 Squadron and SE5's of No 56 Squadron . During the period March to December 1917 a total of 6,000 C.C. gears were issued. From November 1917 the C.C. Gear was fitted to all new British-made aircraft with synchronized guns. Between January and October 1918, 20,000 were delivered and
12204-723: Was that with only 350 employees, Gilead still did not yet have the capability to sell its drugs directly to overseas buyers. To avoid having to license future drugs in order to access international markets, Gilead simply acquired the 480-employee NeXstar, which had already built its own sales force in Europe to market AmBisome there. Viread ( tenofovir ) achieved first approval in 2001 for the treatment of HIV. In 2002, Gilead changed its corporate strategy to focus exclusively on antivirals, and sold its cancer assets to OSI Pharmaceuticals for $ 200 million. In December 2002, Gilead and Triangle Pharmaceuticals announced that Gilead would acquire Triangle for around $ 464 million; Triangle's lead drug
12317-460: Was the principle Corn market for West Middlesex and much of south Buckinghamshire. The plentiful and consistent supplies of water from the River Colne had played an important role in Hillingdon Parish becoming a flour milling centre. The Fray's River is believed to have been cut or modified from the Colne for the use of water mills by John Fray in the 15th century. A map of 1842 shows
12430-475: Was three times Gilead's sales; it sold AmBisome, an injectable fungal treatment, and DaunoXome , an oncology drug taken by HIV patients. That same year, Roche announced FDA approval of Tamiflu ( oseltamivir ) for the treatment of influenza . Tamiflu was originally discovered by Gilead and licensed to Roche for late-phase development and marketing. One reason for entering into the Tamiflu licensing agreement
12543-467: Was touch and go for a long time". Finding a way for Gilead to make money was Riordan's top priority "every second of the day for eight years". Gilead's antisense intellectual property portfolio was sold to Ionis Pharmaceuticals . Gilead debuted on the NASDAQ in January 1992. Its initial public offering raised $ 86.25 million in proceeds. In June 1996, Gilead launched Vistide ( cidofovir injection) for
12656-574: Was used at Pinewood Studios in the 1967 James Bond film You Only Live Twice . In 1952 James Whitson & Co. moved from Sipson and began manufacturing coaches and fire engines in Yiewsley High Street. At its peak the company employed 350 people. They would later manufacture glass-fibre components for commercial vehicles. It would seem to be a curiosity why most of the early companies in Yiewsley chose to have West Drayton as their business address, as they were neither in West Drayton nor in
12769-528: Was valued at US$ 93.4 billion in October 2018. As of 2017, Gilead's challenge is to develop or acquire new blockbuster drugs before its current revenue-producers wane or their patent protection expires. Gilead benefited from the expansion of Medicaid in the ACA; Leerink analyst Geoffrey Porges wrote that Gilead's HIV drugs could face funding pressure under reform proposals. Gilead has $ 32 billion in cash, but $ 27.4 billion
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