103-590: Sacha Pitoëff (born Alexandre Pitoëff ; 11 March 1920 – 21 July 1990) was a Swiss-born French actor and stage director. Pitoëff was born in Geneva , Switzerland, on 11 March 1920, the son of Russian-born parents Ludmilla (née Smanova) and Georges Pitoëff . Both of his parents were born in the city of Tbilisi (in modern-day Georgia ), then a part of the Russian Empire . The Pitoëffs were prominent actors in France, Georges
206-591: A Local Grouping of Transnational Cooperation [ fr ] ( GLCT in French, a public entity under Swiss law) in charge of organizing cooperation within the cross-border metropolitan area of Geneva (in particular metropolitan transports). The Grand Genève GLCT extends over 1,996 km (771 sq mi) and had a population of 1,046,168 in Jan. 2021 (Swiss estimates and French census), 58.3% of them living on Swiss territory, and 41.7% on French territory. Geneva
309-572: A Spy (1971). Toward the end of his acting career, he began appearing in horror films . His final role was as the bookseller Kazanian in Dario Argento 's Inferno (1980). For the last ten years of his life, Pitoëff was a professor at the National School of Theatre Arts and Techniques (ENSATT) in Lyon , where his students included Gérard Depardieu , Jean-Roger Milo and Niels Arestrup . Pitoëff
412-526: A child or children. There were 1,852 households that were made up of unrelated people and 3,038 households that were made up of some sort of institution or another collective housing. In 2000 , there were 743 single family homes (or 10.6% of the total) out of a total of 6,990 inhabited buildings. There were 2,758 multi-family buildings (39.5%), along with 2,886 multi-purpose buildings that were mostly used for housing (41.3%) and 603 other use buildings (commercial or industrial) that also had some housing (8.6%). Of
515-400: A combination of thin wrists and long fingers. Many other disorders can produce the same type of body characteristics as Marfan syndrome. Genetic testing and evaluating other signs and symptoms can help to differentiate these. The following are some of the disorders that can manifest as "marfanoid": There is no cure for Marfan syndrome, but life expectancy has increased significantly over
618-454: A favourable Franco-Swiss tax regime for French residents working in Switzerland. The official language of Geneva (both the city and the canton) is French . English is also common due to a high number of Anglophone residents working in international institutions and the bank sector. In 2000 there were 128,622 residents, or 72.3% of the population, who spoke French as a first language. English
721-510: A gluco-regulatory protein hormone which is the C-terminal cleavage product of profibrillin. The levels of asprosin seen in these people were lower than expected for a heterozygous genotype, consistent with a dominant negative effect. Diagnostic criteria of MFS were agreed upon internationally in 1996. However, Marfan syndrome is often difficult to diagnose in children, as they typically do not show symptoms until reaching pubescence. A diagnosis
824-545: A high risk for early glaucoma and early cataracts . The most serious signs and symptoms associated with Marfan syndrome involve the cardiovascular system : undue fatigue , shortness of breath , heart palpitations , racing heartbeats , or chest pain radiating to the back, shoulder, or arm. Cold arms, hands, and feet can also be linked to MFS because of inadequate circulation. A heart murmur , abnormal reading on an ECG , or symptoms of angina can indicate further investigation. The signs of regurgitation from prolapse of
927-463: A hospital. Large pneumothoraces are likely to be medical emergencies requiring emergency decompression. As an alternative approach, custom-built supports for the aortic root are also being used. As of 2020 this procedure has been used in over 300 people with the first case occurring in 2004. During pregnancy, even in the absence of preconception cardiovascular abnormality, women with Marfan syndrome are at significant risk of aortic dissection, which
1030-565: A large number of residents were members of neither group. Geneva forms part of the Roman Catholic Diocese of Lausanne, Geneva and Fribourg . Marfan syndrome Marfan syndrome ( MFS ) is a multi-systemic genetic disorder that affects the connective tissue . Those with the condition tend to be tall and thin, with long arms, legs , fingers, and toes . They also typically have exceptionally flexible joints and abnormally curved spines . The most serious complications involve
1133-432: A latent form of TGF-β, keeping it sequestered and unable to exert its biological activity. The simplest model suggests reduced levels of fibrillin-1 allow TGF-β levels to rise due to inadequate sequestration. Although how elevated TGF-β levels are responsible for the specific pathology seen with the disease is not proven, an inflammatory reaction releasing proteases that slowly degrade the elastic fibers and other components of
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#17329243918741236-509: A lowest price per square metre (11 sq ft) of 4,874 Swiss francs (CHF), and a maximum price of 21,966 Swiss francs (CHF). William Monter calculates that the city's total population was 12,000–13,000 in 1550, doubling to over 25,000 by 1560. The historical population is given in the following chart: The 2000 census recorded 66,491 residents (37.4% of the population) as Catholic, while 41,289 people (23.20%) belonged to no church or were agnostic or atheist , 24,105 (13.5%) belonged to
1339-553: A lung and occupies the pleural space between the chest wall and a lung. The lung becomes partially compressed or collapsed. This can cause pain, shortness of breath, cyanosis , and, if not treated, death. Other possible pulmonary manifestations of MFS include sleep apnea and idiopathic obstructive lung disease. Pathologic changes in the lungs have been described such as cystic changes, emphysema , pneumonia , bronchiectasis , bullae , apical fibrosis and congenital malformations such as middle lobe hypoplasia. Dural ectasia ,
1442-686: A member of the Municipal Council. The Council holds its meetings in the Town Hall ( Hôtel de Ville ), in the old city. The last election of the Municipal Council was held on 15 March 2020 for the term 2020–2025. Currently, the Municipal Council consists of: 19 members of the Social Democratic Party (PS), 18 Green Party (PES), 14 Les Libéraux-Radicaux (PLR), 8 Christian Democratic People's Party ; (PDC) 7 Geneva Citizens' Movement (MCG), 7 Ensemble à Gauche (an alliance of
1545-451: A mutation similar to that found in the human gene known to cause MFS. This mouse strain recapitulates many of the features of the human disease and promises to provide insights into the pathogenesis of the disease. Reducing the level of normal fibrillin 1 causes a Marfan-related disease in mice. Transforming growth factor beta ( TGF-β ) plays an important role in MFS. Fibrillin-1 directly binds
1648-461: A one-room apartment was 641.60 CHF (US$ 510, £290, €410), a two-room apartment was about 874.46 CHF (US$ 700, £390, €560), a three-room apartment was about 1126.37 CHF (US$ 900, £510, €720) and a six or more room apartment cost an average of 2691.07 CHF (US$ 2150, £1210, €1720). The average apartment price in Geneva was 104.2% of the national average of 1116 CHF. The vacancy rate for the municipality, in 2010 ,
1751-433: A piece of placental tissue through a test called chorionic villus sampling can be performed to make a diagnosis. Another prenatal test can be performed called amniocentesis at 16 to 18 weeks of pregnancy. Marfan syndrome is expressed dominantly. This means a child with one parent a bearer of the gene has a 50% probability of getting the syndrome. In 1996, the first preimplantation genetic testing (PGT) therapy for Marfan
1854-454: A population of 1,046,168 in Jan. 2021 (Swiss estimates and French census), 58.3% of them living on Swiss territory, and 41.7% on French territory. Geneva does not have any sister relationships with other cities. It declares itself related to the entire world. The city of Geneva ( ville de Genève ) had a population 203,856 in 2021 (Jan. estimate) within its small municipal territory of 16 km (6 sq mi). The city of Geneva
1957-523: A third, and many died in their teens and twenties due to cardiovascular problems. Today, cardiovascular symptoms of Marfan syndrome are still the most significant issues in diagnosis and management of the disease, but adequate prophylactic monitoring and prophylactic therapy offers something approaching a normal lifespan, and more manifestations of the disease are being discovered as more patients live longer. Women with Marfan syndrome live longer than men. Marfan syndrome affects males and females equally, and
2060-459: A total of 85,330 apartments (83.8% of the total) were permanently occupied, while 13,644 apartments (13.4%) were seasonally occupied and 2,820 apartments (2.8%) were empty. As of 2009 , the construction rate of new housing units was 1.3 new units per 1000 residents. As of 2003 , the average price to rent an average apartment in Geneva was 1163.30 Swiss francs (CHF) per month (US$ 930, £520, €740 approx. exchange rate from 2003). The average rate for
2163-447: A unique distinction with municipalities such as New York City ( global headquarters of the UN ), Basel ( Bank for International Settlements ), and Strasbourg ( Council of Europe ) as a city which serves as the headquarters of at least one critical international organization without being the capital of a country. The city has been referred to as the world's most compact metropolis and
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#17329243918742266-482: A well-regarded production of Luigi Pirandello 's Henry IV , which he directed and starred in, with Claude Jade . Pitoëff played his first film role in 1952, in the omnibus film The Seven Deadly Sins . Appearing in over 50 films, he is probably best known for his performance in Alain Resnais 's enigmatic Last Year at Marienbad (1960), as the unnamed man who may or may not be Delphine Seyrig 's husband. He
2369-686: Is a global city , a financial centre , and a worldwide centre for diplomacy due to the presence of numerous international organizations , including the headquarters of many agencies of the United Nations and the ICRC and IFRC of the Red Cross . In the aftermath of World War I , it hosted the League of Nations . It was where the Geneva Conventions on humanitarian treatment in war were signed. It shares
2472-476: Is a variant of MFS in which Marfan symptoms are accompanied by features usually associated with neonatal progeroid syndrome (also referred to as Wiedemann–Rautenstrauch syndrome) in which the levels of white adipose tissue are reduced. Since 2010, evidence has been accumulating that MPL is caused by mutations near the 3'-terminus of the FBN1 gene . It has been shown that these people are also deficient in asprosin ,
2575-476: Is associated with variable expressivity ; complete penetrance has been definitively documented. Marfan syndrome is caused by mutations in the FBN1 gene on chromosome 15 , which encodes fibrillin 1 , a glycoprotein component of the extracellular matrix. Fibrillin-1 is essential for the proper formation of the extracellular matrix, including the biogenesis and maintenance of elastic fibers. The extracellular matrix
2678-643: Is at the centre of the Geneva metropolitan area , a Functional Urban Area (as per Eurostat methodology) which extends over Swiss territory (entire Canton of Geneva and part of the canton of Vaud ) and French territory (parts of the departments of Ain and Haute-Savoie ). The Geneva Functional Urban Area covers a land area of 2,292 km (885 sq mi) (24.2% in Switzerland, 75.8% in France) and had 1,053,436 inhabitants in Jan. 2021 (Swiss estimates and French census), 57.8% of them on Swiss territory and 42.2% on French territory. The Geneva metropolitan area
2781-429: Is based on family history and a combination of major and minor indicators of the disorder, rare in the general population, that occur in one individual – for example: four skeletal signs with one or more signs in another body system such as ocular and cardiovascular in one individual. The following conditions may result from MFS, but may also occur in people without any known underlying disorder. In 2010,
2884-403: Is critical for both the structural integrity of connective tissue, but also serves as a reservoir for growth factors. Elastic fibers are found throughout the body, but are particularly abundant in the aorta, ligaments and the ciliary zonules of the eye; consequently, these areas are among the worst affected. A transgenic mouse has been created carrying a single copy of a mutant fibrillin-1,
2987-602: Is generally successful if undertaken on an elective basis. Surgery in the setting of acute aortic dissection or rupture is considerably more problematic. Elective aortic valve/graft surgery is usually considered when aortic root diameter reaches 50 millimeters (2.0 inches), but each case needs to be specifically evaluated by a qualified cardiologist. New valve-sparing surgical techniques are becoming more common. As people with Marfan syndrome live longer, other vascular repairs are becoming more common, e.g., repairs of descending thoracic aortic aneurysms and aneurysms of vessels other than
3090-401: Is increased. Care should be taken to attempt repair of damaged heart valves rather than replacement. Individuals with Marfan syndrome may be affected by various lung-related problems. One study found that only 37% of the patient sample studied (mean age 32±14 years; M 45%) had normal lung function. Spontaneous pneumothorax is common. In spontaneous unilateral pneumothorax, air escapes from
3193-564: Is inherited from a parent with the condition, while in about 25% it is a new mutation. Diagnosis is often based on the Ghent criteria, family history and genetic testing (DNA analysis). There is no known cure for MFS. Many of those with the disorder have a normal life expectancy with proper treatment. Management often includes the use of beta blockers such as propranolol or atenolol or, if they are not tolerated, calcium channel blockers or ACE inhibitors . Surgery may be required to repair
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3296-660: Is made up of the Canton of Geneva , the Nyon District (in the canton of Vaud), and the Pôle métropolitain du Genevois français [ fr ] (literally 'Metropolitan hub of the French Genevan territory'), this last one a federation of eight French intercommunal councils in Ain and Haute-Savoie . The Grand Genève GLCT extends over 1,996 km (771 sq mi) and had
3399-403: Is not often visible in the early stages. A worsening of symptoms might warrant an MRI of the lower spine. Dural ectasia that has progressed to this stage would appear in an MRI as a dilated pouch wearing away at the lumbar vertebrae . Other spinal issues associated with MFS include degenerative disc disease , spinal cysts , and dysfunction of the autonomic nervous system . Each parent with
3502-482: Is often fatal even when rapidly treated. Women with Marfan syndrome, then, should receive a thorough assessment prior to conception, and echocardiography should be performed every six to 10 weeks during pregnancy, to assess the aortic root diameter. For most women, safe vaginal delivery is possible. Prenatal testing can be performed in females with Marfan syndrome to determine if the condition has been inherited in their child. At 10 to 12 weeks of pregnancy, examining
3605-454: Is one of the clinical examination tests for Marfan disease in the hands. It is a clinical test in which the tip of the thumb extends beyond the palm when the thumb is clasped in the clenched hand. Besides affecting height and limb proportions, people with Marfan syndrome may have abnormal lateral curvature of the spine scoliosis , thoracic lordosis , abnormal indentation ( pectus excavatum ) or protrusion ( pectus carinatum ) of
3708-560: Is one of the fastest growing in Europe. Its population rose from 906,603 in Jan. 2010 to 1,053,436 in Jan. 2021, which means the metropolitan area registered a population growth rate of +1.39% per year during those 11 years. Growth is higher in the French part of the metropolitan area (+1.80% per year between 2010 and 2021) than in the Swiss part (+1.10% per year between 2010 and 2021), as Geneva attracts many French commuters due to high Swiss salaries and
3811-595: Is the capital of the Republic and Canton of Geneva , and a centre for international diplomacy . Geneva hosts the highest number of international organizations in the world. The city of Geneva ( Ville de Genève ) had a population of 203,856 in January 2021 within its municipal territory of 16 km (6 sq mi). The Geneva metropolitan area as officially defined by Eurostat , including suburbs and exurbs in Vaud and
3914-437: Is wasteland. Of the built-up area, industrial buildings made up 3.4%, housing and buildings made up 46.2% and transportation infrastructure 25.8%, while parks, green belts and sports fields made up 15.7%. Of the agricultural land, 0.3% is used for growing crops. Of the water in the municipality, 0.2% is composed of lakes and 2.9% is rivers and streams. The altitude of Geneva is 373.6 m (1,225.7 ft) and corresponds to
4017-408: Is where the entire distal phalanx is visible beyond the ulnar border of the hand, caused by a combination of hypermobility of the thumb as well as a thumb which is longer than usual. The wrist sign (Walker-Murdoch sign) is elicited by asking the person to curl the thumb and fingers of one hand around the other wrist. A positive wrist sign is where the little finger and the thumb overlap, caused by
4120-571: The Directory annexed Geneva. At the end of the Napoleonic Wars , on 1 June 1814, Geneva was admitted to the Swiss Confederation . In 1907, the separation of Church and State was adopted. Geneva flourished in the 19th and 20th centuries, becoming the seat of many international organizations. Geneva is located at 46°12' North, 6°09' East, at the south-western end of Lake Geneva , where
4223-504: The Green Party (11.4%), the PDC (10.7%), and the solidaritéS (8.8%). In the federal election a total of 36,490 votes were cast, and the voter turnout was 44.1%. The city centre of Geneva is located only 1.9 km (1.2 mi) from the border of France . As a result, the urban area and the metropolitan area largely extend across the border on French territory. Due to the small size of
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4326-659: The PdA / solidaritéS (10%, +1.3), the PDC (5.4%, -5.3), the pvl (5%, +2.9), and MCR (4.9%, -2.7). In the federal election a total of 34,319 votes were cast, and the voter turnout was 39.6%. In the 2015 federal election for the Swiss National Council the most popular party was the PS which received 23.8% of the vote. The next five most popular parties were the PLR (17.6%), the UDC (16.3%),
4429-639: The Rhône flows out. It is surrounded by three mountain chains, each belonging to the Jura : the Jura main range lies north-westward, the Vuache southward, and the Salève south-eastward. The city covers an area of 15.93 km (6.2 sq mi), while the area of the canton is 282 km (108.9 sq mi), including the two small exclaves of Céligny in Vaud . The part of
4532-615: The Swiss Reformed Church , and 8,698 (4.89%) were Muslim . There were also 3,959 members of an Orthodox church (2.22%), 220 individuals (or about 0.12% of the population) who belonged to the Christian Catholic Church of Switzerland , 2,422 (1.36%) who belonged to another Christian church, and 2,601 people (1.46%) who were Jewish. There were 707 individuals who were Buddhist, 474 who were Hindu and 423 who belonged to another church. 26,575 respondents (14.93%) did not answer
4635-429: The heart and aorta , with an increased risk of mitral valve prolapse and aortic aneurysm . The lungs, eyes, bones, and the covering of the spinal cord are also commonly affected. The severity of the symptoms is variable. MFS is caused by a mutation in FBN1 , one of the genes that make fibrillin , which results in abnormal connective tissue. It is an autosomal dominant disorder. In about 75% of cases, it
4738-401: The heart rate , and lowering the person's blood pressure . The American Heart Association made the following recommendations for people with Marfan syndrome with no or mild aortic dilation: Management often includes the use of beta blockers such as propranolol or if not tolerated calcium channel blockers or ACE inhibitors . Beta blockers are used to reduce the stress exerted on
4841-431: The lens can be detected clinically in about 60% of people with Marfan syndrome by the use of a slit-lamp biomicroscope. If the lens subluxation is subtle, then imaging with high-resolution ultrasound biomicroscopy might be used. Other signs and symptoms affecting the eye include increased length along an axis of the globe, myopia, corneal flatness, strabismus , exotropia , and esotropia . Those with MFS are also at
4944-438: The sternum , abnormal joint flexibility , a high-arched palate with crowded teeth and an overbite, flat feet , hammer toes , stooped shoulders, and unexplained stretch marks on the skin. It can also cause pain in the joints, bones, and muscles. Some people with Marfan have speech disorders resulting from symptomatic high palates and small jaws. Early osteoarthritis may occur. Other signs include limited range of motion in
5047-483: The "Peace Capital". In 2023, Geneva was ranked as the world's tenth most important financial centre by the Global Financial Centres Index , second in Europe behind London. In 2019, Geneva was ranked among the ten most liveable cities in the world by Mercer , alongside Zürich and Basel, as well as the thirteenth most expensive city in the world. In a UBS ranking of global cities in 2018, Geneva
5150-500: The Administrative Council and the administration. The delegates are selected by means of a system of proportional representation with a seven percent threshold. The sessions of the Municipal Council are public. Unlike members of the Administrative Council, members of the Municipal Council are not politicians by profession, and they are paid a fee based on their attendance. Any resident of Geneva allowed to vote can be elected as
5253-549: The CRFG created in 1973. Finally in 2012 the Projet d’agglomération franco-valdo-genevois was renamed Grand Genève ('Greater Geneva'), and the following year it was transformed into a Local Grouping of Transnational Cooperation [ fr ] ( GLCT ), a public entity under Swiss law, which now serves as the executive body of the Grand Genève . The Grand Genève GLCT
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#17329243918745356-467: The CRFG defined for the first time a planning territory called agglomération franco-valdo-genevoise ('Franco- Vaud -Genevan urban area'). 2001 saw the creation of a Comité stratégique de développement des transports publics régionaux ('Strategic Committee for the Development of Regional Public Transports', DTPR ), a committee which adopted in 2003 a 'Charter for Public Transports', first step in
5459-536: The French departments of Ain and Haute-Savoie , extends over 2,292 km (885 sq mi) and had a population of 1,053,436 in 2021. Since 2013, the Canton of Geneva, the Nyon District (in the canton of Vaud), and the Pôle métropolitain du Genevois français [ fr ] ( lit. ' Metropolitan hub of the French Genevan territory ' , a federation of eight French intercommunal councils), have formed Grand Genève ("Greater Geneva"),
5562-435: The Ghent nosology was revised, and new diagnostic criteria superseded the previous agreement made in 1996. The seven new criteria can lead to a diagnosis: In the absence of a family history of MFS: In the presence of a family history of MFS (as defined above): The thumb sign (Steinberg's sign) is elicited by asking the person to flex the thumb as far as possible and then close the fingers over it. A positive thumb sign
5665-671: The Late Roman Empire , and acquired its first bishop in the 5th century, having been connected to the Bishopric of Vienne in the 4th. In the Middle Ages , Geneva was ruled by a count under the Holy Roman Empire until the late 14th century, when it was granted a charter giving it a high degree of self-governance. Around this time, the House of Savoy came to at least nominally dominate
5768-412: The Municipal Council are carried out by the Administrative Council. Elections for the Administrative Council are held every five years. The current term of office is from 1 June 2020 to 31 May 2025. The delegates take office due to a winner-takes-all election ( French : scrutin majoritaire , Swiss Standard German : Majorzwahl or Majorz ). The mayor and vice change each year, while
5871-520: The age of 70. Geneva Geneva ( / dʒ ə ˈ n iː v ə / jə- NEE -və ; Arpitan : [dzəˈnɛva] ; French: Genève [ʒənɛv] ) is the second-most populous city in Switzerland (after Zürich ) and the most populous in the French-speaking Romandy . Situated in the southwest of the country, where the Rhône exits Lake Geneva , it
5974-506: The altitude of the largest of the Pierres du Niton , two large rocks emerging from the lake which date from the last ice age . This rock was chosen by General Guillaume Henri Dufour as the reference point for surveying in Switzerland. The second main river of Geneva is the Arve , which flows into the Rhône just west of the city centre. Mont Blanc can be seen from Geneva and is an hour's drive from
6077-410: The aorta and to decrease aortic dilation. If the dilation of the aorta progresses to a significant-diameter aneurysm , causes a dissection or a rupture, or leads to failure of the aortic or other valve, then surgery (possibly a composite aortic valve graft or valve-sparing aortic root replacement ) becomes necessary. Although aortic graft surgery (or any vascular surgery) is a serious undertaking it
6180-447: The aorta or replace a heart valve . Avoiding strenuous exercise is recommended for those with the condition. About 1 in 5,000 to 1 in 10,000 people have MFS. Rates of the condition are similar in different regions of the world. It is named after French pediatrician Antoine Marfan , who first described it in 1896. More than 30 signs and symptoms are variably associated with Marfan syndrome. The most prominent of these affect
6283-456: The aorta. The skeletal and ocular manifestations of Marfan syndrome can also be serious, although not life-threatening. These symptoms are usually treated in an appropriate manner for the condition, such as with pain medications or muscle relaxants . Because Marfan syndrome may cause asymptomatic spinal abnormalities, any spinal surgery contemplated on a person Marfan should only follow detailed imaging and careful surgical planning, regardless of
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#17329243918746386-504: The border in France, dominates the southerly view from the city centre, and Mont Blanc , the highest of the Alpine range, is visible from most of the city, towering high above Chamonix , which, along with Morzine, Le Grand Bornand, La Clusaz, and resorts of the Grand Massif such as Samoens, Morillon, and Flaine, are the closest French skiing destinations to Geneva. During the years 2000–2009,
6489-440: The city. The climate of Geneva is a temperate climate , more specifically an oceanic climate ( Köppen climate classification : Cfb ). Winters are cool, usually with light frosts at night and thawing conditions during the day. Summers are relatively warm. Precipitation is adequate and is relatively well-distributed throughout the year, although autumn is slightly wetter than other seasons. Ice storms near Lac Léman are normal in
6592-684: The city. In the 15th century, an oligarchic republican government emerged with the creation of the Grand Council . In the first half of the 16th century, the Protestant Reformation reached the city, causing religious strife, during which Savoy rule was thrown off and Geneva allied itself with the Swiss Confederacy . In 1541, with Protestantism on the rise, John Calvin , the Protestant Reformer and proponent of Calvinism , became
6695-465: The condition has a 50% risk of passing the genetic defect on to any child due to its autosomal dominant nature. Most individuals with MFS have another affected family member. About 75% of cases are inherited. On the other hand, about 15–30% of all cases are due to de novo genetic mutations ; such spontaneous mutations occur in about one in 20,000 births. Marfan syndrome is also an example of dominant negative mutation and haploinsufficiency . It
6798-419: The development of a metropolitan, cross-border commuter rail network (see Léman Express ). In 2004, a public transnational body called Projet d’agglomération franco-valdo-genevois ('Franco-Vaud-Genevan urban area project') was created to serve as the main body of metropolitan cooperation for the planning territory defined in 1997, with more local French councils taking part in this new public body than in
6901-513: The executive government of the city of Geneva and operates as a collegiate authority. It is composed of five councilors ( Conseiller administratif / Conseillère administrative ), each presiding over a department. The president of the executive department acts as mayor ( la maire/le maire ). In the governmental year 2021–2022, the Administrative Council is presided over by Madame la maire de Genève Frédérique Perler . Departmental tasks, coordination measures and implementation of laws decreed by
7004-577: The extracellular matrix is known to occur. The importance of the TGF-β pathway was confirmed with the discovery of the similar Loeys–Dietz syndrome involving the TGFβR2 gene on chromosome 3 , a receptor protein of TGF-β. Marfan syndrome has often been confused with Loeys–Dietz syndrome, because of the considerable clinical overlap between the two pathologies. Marfanoid–progeroid–lipodystrophy syndrome (MPL), also referred to as Marfan lipodystrophy syndrome (MFLS),
7107-514: The five seats and, for the first time in history, a female majority in the election held on 15 March / 5 April 2020. Except for the mayor, all other councillors have been elected for the first time. Le Conseil municipal of Geneva for the mandate period of 2020–2025 The Municipal Council ( French : Conseil municipal ) holds legislative power . It is made up of 80 members, with elections held every five years. The Municipal Council makes regulations and by-laws that are executed by
7210-585: The heads of the other departments are assigned by the collegiate. The executive body holds its meetings in the Palais Eynard, near the Parc des Bastions . As of 2020, Geneva's Administrative Council is made up of two representatives each of the Social Democratic Party (PS) and the Green Party (PES), and one member of the Christian Democratic Party (PDC). This gives the left-wing parties four out of
7313-448: The hips due to the femoral head protruding into abnormally deep hip sockets . In Marfan syndrome, the health of the eye can be affected in many ways, but the principal change is partial lens dislocation , where the lens is shifted out of its normal position. This occurs because of weakness in the ciliary zonules , the connective tissue strands which suspend the lens within the eye. The mutations responsible for Marfan syndrome weaken
7416-618: The indication for surgery. The ocular complications of MFS can often be treated with surgery. Ectopia lentis can be treated, as artificial lenses can be surgically implanted. In addition, surgery can address glaucoma and cataracts . Treatment of a spontaneous pneumothorax is dependent on the volume of air in the pleural space and the natural progression of the individual's condition. A small pneumothorax might resolve without active treatment in one to two weeks. Recurrent pneumothoraces might require chest surgery. Moderately sized pneumothoraces might need chest drain management for several days in
7519-404: The lake that is attached to Geneva has an area of 38 km (14.7 sq mi) and is sometimes referred to as petit lac ('small lake'). The canton has only a 4.5 km-long (2.8 mi) border with the rest of Switzerland. Of 107.5 km (66.8 mi) of the border, 103 are shared with France, the department of Ain to the north and west and the department of Haute-Savoie to
7622-505: The last few decades and is now similar to that of the average person. Regular checkups are recommended to monitor the health of the heart valves and the aorta . Marfan syndrome is treated by addressing each issue as it arises and, in particular, preventive medication even for young children to slow progression of aortic dilation. The goal of this treatment strategy is to slow the progression of aortic dilation and prevent any damage to heart valves by eliminating heart arrhythmias , minimizing
7725-406: The left parties PST-POP ( Parti Suisse du Travail – Parti Ouvrier et Populaire ) and solidaritéS ), 6 Swiss People's Party (UDC). In the 2019 federal election for the Swiss National Council the most popular party was the Green Party which received 26% (+14.6) of the vote. The next seven most popular parties were the PS (17.9%, -5.9), PLR (15.1%, -2.4), the UDC (12.6%, -3.7),
7828-891: The mean yearly temperature was 11 °C and the mean number of sunshine-hours per year was 2003. The highest temperature recorded in Genève–Cointrin was 39.7 °C (103.5 °F) in July 2015, and the lowest temperature recorded was −20.0 °C (−4.0 °F) in February 1956. The city is divided into eight quartiers , or districts, sometimes composed of several neighbourhoods. On the left bank are: (1) Jonction, (2) Centre, Plainpalais , and Acacias; (3) Eaux-Vives; and (4) Champel . The right bank includes: (1) Saint-Jean and Charmilles; (2) Servette and Petit-Saconnex; (3) Grottes and Saint-Gervais; and (4) Paquis and Nations. The Administrative Council ( French : Conseil administratif ) constitutes
7931-407: The mitral or aortic valves (which control the flow of blood through the heart) result from cystic medial degeneration of the valves, which is commonly associated with MFS (see mitral valve prolapse , aortic regurgitation ). However, the major sign that would lead a doctor to consider an underlying condition is a dilated aorta or an aortic aneurysm . Sometimes, no heart problems are apparent until
8034-496: The municipality of Geneva (16 km (6 sq mi)) and extension of the urban area over an international border, official bodies of transnational cooperation were developed as early as the 1970s to manage the cross-border Greater Geneva area at a metropolitan level. In 1973, a Franco-Swiss agreement created the Comité régional franco-genevois ('Franco-Genevan Regional Committee', CRFG ). In 1997 an 'Urban planning charter' of
8137-498: The municipality, and an average of 1.9 persons per household. There were 44,373 households that consist of only one person and 2,549 households with five or more people. Out of a total of 89,269 households that answered this question, 49.7% were households made up of just one person and there were 471 adults who lived with their parents. Of the rest of the households, there are 17,429 married couples without children, 16,607 married couples with children. There were 5,499 single parents with
8240-749: The mutation shows no ethnic or geographical bias. Estimates indicate about 1 in 5,000 to 10,000 individuals have Marfan syndrome. Marfan syndrome is named after Antoine Marfan , the French pediatrician who first described the condition in 1896 after noticing striking features in a five-year-old girl. The gene linked to the disease was first identified by Francesco Ramirez at the Mount Sinai Medical Center in New York City in 1991. Notable people who have or had Marfan syndrome include: Other historical figures and celebrities have appeared on lists of people with Marfan syndrome, but from case to case
8343-433: The population has changed at a rate of 7.2%; a rate of 3.4% due to migration and at a rate of 3.4% due to births and deaths. As of 2008 , the gender distribution of the population was 47.8% male and 52.2% female. The population was made up of 46,284 Swiss men (24.2% of the population) and 45,127 (23.6%) non-Swiss men. There were 56,091 Swiss women (29.3%) and 43,735 (22.9%) non-Swiss women. As of 2000 approximately 24.3% of
8446-401: The population of Swiss citizens increased by 33, while the foreign population increased by 619. There were 465 Swiss men and 498 Swiss women who emigrated from Switzerland. At the same time, there were 2933 non-Swiss men and 2662 non-Swiss women who immigrated from another country to Switzerland. The total Swiss population change in 2008 (from all sources, including moves across municipal borders)
8549-511: The population of the municipality were born in Geneva and lived there in 2000 – 43,296. A further 11,757 or 6.6% who were born in the same canton, while 27,359 or 15.4% were born elsewhere in Switzerland, and 77,893 or 43.8% were born outside of Switzerland. In 2008 , there were 1,147 live births to Swiss citizens and 893 births to non-Swiss citizens, and in the same time span there were 1,114 deaths of Swiss citizens and 274 non-Swiss citizen deaths. Ignoring immigration and emigration,
8652-469: The question. According to 2012 statistics by Swiss Bundesamt für Statistik 49.2% of the population were Christian , (34.2% Catholic , 8.8% Swiss Reformed (organized in the Protestant Church of Geneva ) and 6.2% other Christians, mostly other Protestants ), 38% of Genevans were non-religious , 6.1% were Muslim and 1.6% were Jews. Geneva has historically been considered a Protestant city and
8755-422: The single family homes, 197 were built before 1919, while 20 were built between 1990 and 2000. The greatest number of single family homes (277) were built between 1919 and 1945. In 2000 , there were 101,794 apartments in the municipality. The most common apartment size was 3 rooms of which there were 27,084. There were 21,889 single room apartments and 11,166 apartments with five or more rooms. Of these apartments,
8858-432: The skeletal, cardiovascular, and ocular systems, but all fibrous connective tissue throughout the body can be affected. Most of the readily visible signs are associated with the skeletal system . Many people with Marfan syndrome grow to above-average height, and some have disproportionately long, slender limbs with thin, weak wrists and long fingers and toes . The Steinberg sign, also known as the thumb sign,
8961-412: The south and east. Of the land in the city, 0.24 km (0.093 sq mi), or 1.5%, is used for agricultural purposes, while 0.5 km (0.19 sq mi), or 3.1%, is forested. The rest of the land, 14.63 km (5.65 sq mi), or 91.8%, is built up (buildings or roads), 0.49 km (0.19 sq mi), or 3.1%, is either rivers or lakes and 0.02 km (4.9 acres), or 0.1%,
9064-415: The spiritual leader of the city and established the Republic of Geneva . By the 18th century, Geneva had come under the influence of Catholic France, which cultivated the city as its own. France tended to be at odds with the ordinary townsfolk, which inspired the failed Geneva Revolution of 1782 , an attempt to win representation in the government for men of modest means. In 1798, revolutionary France under
9167-653: The war he returned to Paris, becoming general manager at the Théâtre des Bouffes du Nord . He made his directorial debut with a 1950 staging of Uncle Vanya , which proved both a critical and commercial success. He became a fixture of Parisian theatre in the 1960s, becoming the director of his own troupe. His repertoire included works by Jean Genet , Eugène Ionesco , Hugo Claus , Robert Musil , Anna Langfus and Anton Chekhov . With Romy Schneider , he staged The Seagull , Uncle Vanya and Three Sisters at Théâtre de l'Œuvre . In 1967, he achieved his greatest success with
9270-401: The weakening of the connective tissue (cystic medial degeneration) in the ascending aorta causes an aortic aneurysm or aortic dissection , a surgical emergency. An aortic dissection is most often fatal and presents with pain radiating down the back, giving a tearing sensation. Because underlying connective tissue abnormalities cause MFS, the incidence of dehiscence of prosthetic mitral valve
9373-442: The weakening of the connective tissue of the dural sac encasing the spinal cord , can result in a loss of quality of life . It can be present for a long time without producing any noticeable symptoms. Symptoms that can occur are lower back pain, leg pain, abdominal pain, other neurological symptoms in the lower extremities, or headaches – symptoms which usually diminish when lying flat. On X-ray , however, dural ectasia
9476-644: The winter: Geneva can be affected by the Bise , a north-easterly wind. This can lead to severe icing in winter. In summer, many people swim in the lake and patronise public beaches such as Genève Plage and the Bains des Pâquis . The city, in certain years, receives snow during colder months. The nearby mountains are subject to substantial snowfall and are suitable for skiing. Many world-renowned ski resorts such as Verbier and Crans-Montana are less than three hours away by car. Mont Salève (1,379 m (4,524 ft)), just across
9579-411: The zonules and cause them to stretch. The inferior zonules are most frequently stretched resulting in the lens shifting upwards and outwards, but it can shift in other directions as well. Nearsightedness (myopia), and blurred vision are common due to connective tissue defects in the eye. Farsightedness can also result particularly if the lens is highly subluxated. Subluxation (partial dislocation) of
9682-464: Was 0.25%. In June 2011, the average price of an apartment in and around Geneva was 13,681 CHF per square metre (11 sq ft). The average can be as high as 17,589 Swiss francs (CHF) per square metre (11 sq ft) for a luxury apartment and as low as 9,847 Swiss francs (CHF) for an older or basic apartment. For houses in and around Geneva, the average price was 11,595 Swiss francs (CHF) per square metre (11 sq ft) (June 2011), with
9785-579: Was a founding member of the Cartel des Quatre (Group of Four), a group including Louis Jouvet , Charles Dullin , and Gaston Baty , dedicated to rejuvenating the French theatre. Sacha graduated from Lycée Pasteur in Neuilly-sur-Seine , outside Paris . He studied acting and stage direction under Jouvet at the Théâtre de l'Athénée . During World War II , the younger Pitoëff followed his mother back to Switzerland, where he played his earliest roles. After
9888-566: Was an increase of 135 and the non-Swiss population increased by 3181 people. This represents a population growth rate of 1.8%. As of 2000 , children and teenagers (0–19 years old) made up 18.2% of the population, while adults (20–64 years old) made up 65.8% and seniors (over 64 years old) make up 16%. As of 2000 , there were 78,666 people who were single and never married in the municipality. There were 74,205 married individuals, 10,006 widows or widowers and 15,087 individuals who are divorced. As of 2000 , there were 86,231 private households in
9991-462: Was conducted; in essence PGT means conducting a genetic test on early-stage IVF embryo cells and discarding those embryos affected by the Marfan mutation. Prior to modern cardiovascular surgical techniques and medications such as losartan , and metoprolol , the prognosis of those with Marfan syndrome was not good: a range of untreatable cardiovascular issues was common. Lifespan was reduced by at least
10094-497: Was featured in roles of various sizes in such films as Henri-Georges Clouzot 's Les Espions (1957), Peter Ustinov 's Lady L (1965), René Clément 's Is Paris Burning? (1966), and Jacques Demy 's Donkey Skin (1970). He also appeared in several Hollywood productions, including Anatole Litvak 's Anastasia (1956) and The Night of the Generals (1967), Mark Robson 's The Prize (1963) and Dick Clement 's To Catch
10197-610: Was known as pagus major Genevensis or Comitatus Genevensis (also Gebennensis ). After 1400 it became the Genevois province of Savoy (albeit not extending to the city proper, until the reformation of the seat of the Bishop of Geneva ). Geneva was an Allobrogian border town, fortified against the Helvetii tribe, when the Roman Republic took it in 121 BC. It became Christian under
10300-475: Was known as the Protestant Rome due to it being the base of John Calvin , William Farel , Theodore Beza and other Protestant reformers . Over the past century, substantial immigration from France and other predominantly Catholic countries, as well as general secularization, has changed its religious landscape. As a result, three times as many Roman Catholics as Protestants lived in the city in 2000, while
10403-447: Was married to French actress Luce Garcia-Ville, until her death by suicide in 1975. He had two siblings, actress Svetlana Pitoëff and writer Aniouta Pitoeff. His height and distinctively-gaunt, lanky appearance may have been a consequence of Marfan syndrome . Having suffered from depression in the final years of his life, he died in Paris at Pitié-Salpêtrière Hospital on 21 July 1990, at
10506-689: Was ranked first for gross earnings , second most expensive, and fourth in purchasing power . The city was mentioned in Latin texts, by Caesar , with the spelling Genava , probably from the Celtic * genawa- from the stem * genu- ("mouth"), in the sense of an estuary , an etymology shared with the Italian port city of Genoa (in Italian Genova ). The medieval county of Geneva in Middle Latin
10609-410: Was the second most common (7,853 or 4.4%), followed by Spanish (7,462 or 4.2%), Italian (7,320 or 4.1%), and German (7,050 or 4.0%); 113 spoke Romansh , an official language in Switzerland. In the city of Geneva, as of 2013 , 48% of the population are resident foreign nationals. For a list of the largest groups of foreign residents see the cantonal overview . Over the last 10 years (1999–2009),
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